WO2008053275A3 - Novel collection of hcdr3 regions and uses therefor - Google Patents
Novel collection of hcdr3 regions and uses therefor Download PDFInfo
- Publication number
- WO2008053275A3 WO2008053275A3 PCT/IB2006/004301 IB2006004301W WO2008053275A3 WO 2008053275 A3 WO2008053275 A3 WO 2008053275A3 IB 2006004301 W IB2006004301 W IB 2006004301W WO 2008053275 A3 WO2008053275 A3 WO 2008053275A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hcdr3
- collection
- members
- antibody
- regions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008546696A JP5405831B2 (en) | 2005-12-20 | 2006-12-15 | Novel assembly of H-CDR3 region and use thereof |
CA2634387A CA2634387C (en) | 2005-12-20 | 2006-12-15 | Novel collection of hcdr3 regions and uses therefor |
DK06851829.9T DK1979378T3 (en) | 2005-12-20 | 2006-12-15 | New collection of HCDR3 areas and applications therefore |
CN2006800530247A CN101389655B (en) | 2005-12-20 | 2006-12-15 | Novel collection of HCDR3 regions and uses therefor |
AU2006350452A AU2006350452B2 (en) | 2005-12-20 | 2006-12-15 | Novel collection of HCDR3 regions and uses therefor |
EP06851829A EP1979378B1 (en) | 2005-12-20 | 2006-12-15 | Novel collection of hcdr3 regions and uses therefor |
US12/158,181 US8273688B2 (en) | 2005-12-20 | 2006-12-15 | Collection of HCDR3 regions and uses therefor |
MX2008008220A MX2008008220A (en) | 2005-12-20 | 2006-12-15 | Novel collection of hcdr3 regions and uses therefor. |
NZ569359A NZ569359A (en) | 2005-12-20 | 2006-12-15 | Novel collection of HCDR3 regions and uses therefor |
ES06851829T ES2394722T3 (en) | 2005-12-20 | 2006-12-15 | New set of HCDR3 regions and their uses |
IL192315A IL192315A0 (en) | 2005-12-20 | 2008-06-19 | Novel collection of hcdr3 regions and uses therefor |
NO20083171A NO20083171L (en) | 2005-12-20 | 2008-07-18 | New collection of HCDR3 ranges and applications thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75163305P | 2005-12-20 | 2005-12-20 | |
US60/751,633 | 2005-12-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008053275A2 WO2008053275A2 (en) | 2008-05-08 |
WO2008053275A3 true WO2008053275A3 (en) | 2008-08-21 |
Family
ID=39273832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2006/004301 WO2008053275A2 (en) | 2005-12-20 | 2006-12-15 | Novel collection of hcdr3 regions and uses therefor |
Country Status (15)
Country | Link |
---|---|
US (1) | US8273688B2 (en) |
EP (1) | EP1979378B1 (en) |
JP (1) | JP5405831B2 (en) |
KR (1) | KR20080080653A (en) |
CN (1) | CN101389655B (en) |
AU (1) | AU2006350452B2 (en) |
CA (1) | CA2634387C (en) |
DK (1) | DK1979378T3 (en) |
ES (1) | ES2394722T3 (en) |
IL (1) | IL192315A0 (en) |
MX (1) | MX2008008220A (en) |
NO (1) | NO20083171L (en) |
NZ (1) | NZ569359A (en) |
WO (1) | WO2008053275A2 (en) |
ZA (1) | ZA200806016B (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
UA97469C2 (en) * | 2005-07-25 | 2012-02-27 | Емерджент Продакт Дівелопмент Сіетл, Елелсі | Humanized cd37-specific binding immunoglobulin molecule |
EP2418223A3 (en) * | 2006-06-12 | 2013-01-16 | Emergent Product Development Seattle, LLC | Single-chain multivalent binding proteins with effector function |
US8691730B2 (en) * | 2007-09-14 | 2014-04-08 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
EP2098536A1 (en) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation and identification of antigen- or ligand-specific binding proteins |
US9873957B2 (en) | 2008-03-13 | 2018-01-23 | Dyax Corp. | Libraries of genetic packages comprising novel HC CDR3 designs |
DK2132228T3 (en) | 2008-04-11 | 2011-10-10 | Emergent Product Dev Seattle | CD37 immunotherapeutic agent and combination with its bifunctional chemotherapeutic agent |
DK2281078T3 (en) * | 2008-04-24 | 2015-02-02 | Dyax Corp | LIBRARIES OF RE-PACKAGES INCLUDING UNKNOWN HC-CDR1, -CDR2 AND -CDR3 AND UNKNOWN LC-CDR1, -CDR2 AND-CDR3 DESIGNS |
EP2435568B1 (en) | 2009-05-29 | 2014-07-02 | MorphoSys AG | Collection of synthetic antibodies for treating disease |
AU2010291902A1 (en) * | 2009-09-14 | 2012-04-05 | Dyax Corp. | Libraries of genetic packages comprising novel HC CDR3 designs |
DK3336225T3 (en) | 2010-07-16 | 2020-03-30 | Adimab Llc | ANTIBODY LIBRARIES |
CN103237809B (en) | 2010-11-19 | 2016-09-07 | 莫佛塞斯公司 | One set and using method thereof |
US11352426B2 (en) | 2015-09-21 | 2022-06-07 | Aptevo Research And Development Llc | CD3 binding polypeptides |
CN105274630A (en) * | 2015-11-25 | 2016-01-27 | 苏州泓迅生物科技有限公司 | Method for synthesizing controllable humanized antibody library based on combinatorial synthesis technique and application |
JP6959260B2 (en) * | 2016-01-19 | 2021-11-02 | ズムトール バイオロジクス、インコーポレイテッド | A method for preparing a synthetic antibody library, the library, and its application. |
EP3293293A1 (en) | 2016-09-08 | 2018-03-14 | Italfarmaco SpA | Hc-cdr3-only libraries with reduced combinatorial redundancy and optimized loop length distribution |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6828422B1 (en) * | 1995-08-18 | 2004-12-07 | Morphosys Ag | Protein/(poly)peptide libraries |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE219517T1 (en) | 1995-08-18 | 2002-07-15 | Morphosys Ag | PROTEIN/(POLY)PEPTIDE LIBRARIES |
IL142025A0 (en) | 1999-07-20 | 2002-03-10 | Morphosys Ag | Novel methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds |
AU2002249854B2 (en) | 2000-12-18 | 2007-09-20 | Dyax Corp. | Focused libraries of genetic packages |
-
2006
- 2006-12-15 MX MX2008008220A patent/MX2008008220A/en not_active Application Discontinuation
- 2006-12-15 JP JP2008546696A patent/JP5405831B2/en active Active
- 2006-12-15 WO PCT/IB2006/004301 patent/WO2008053275A2/en active Application Filing
- 2006-12-15 AU AU2006350452A patent/AU2006350452B2/en active Active
- 2006-12-15 US US12/158,181 patent/US8273688B2/en active Active
- 2006-12-15 DK DK06851829.9T patent/DK1979378T3/en active
- 2006-12-15 NZ NZ569359A patent/NZ569359A/en unknown
- 2006-12-15 KR KR1020087017753A patent/KR20080080653A/en not_active Application Discontinuation
- 2006-12-15 CN CN2006800530247A patent/CN101389655B/en active Active
- 2006-12-15 ES ES06851829T patent/ES2394722T3/en active Active
- 2006-12-15 EP EP06851829A patent/EP1979378B1/en active Active
- 2006-12-15 CA CA2634387A patent/CA2634387C/en active Active
-
2008
- 2008-06-19 IL IL192315A patent/IL192315A0/en unknown
- 2008-07-10 ZA ZA200806016A patent/ZA200806016B/en unknown
- 2008-07-18 NO NO20083171A patent/NO20083171L/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6828422B1 (en) * | 1995-08-18 | 2004-12-07 | Morphosys Ag | Protein/(poly)peptide libraries |
Non-Patent Citations (4)
Title |
---|
BARRIOS YVELISE ET AL: "Length of the antibody heavy chain complementarity determining region 3 as a specificity-determining factor.", JOURNAL OF MOLECULAR RECOGNITION : JMR 2004 JUL-AUG, vol. 17, no. 4, July 2004 (2004-07-01), pages 332 - 338, XP002482520, ISSN: 0952-3499 * |
KNAPPIK A ET AL: "Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 296, no. 1, 11 February 2000 (2000-02-11), pages 57 - 86, XP004461525, ISSN: 0022-2836 * |
LEE C V ET AL: "High-affinity Human Antibodies from Phage-displayed Synthetic Fab Libraries with a Single Framework Scaffold", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 340, no. 5, 23 July 2004 (2004-07-23), pages 1073 - 1093, XP004518119, ISSN: 0022-2836 * |
ZEMLIN M ET AL: "Expressed Murine and Human CDR-H3 Intervals of Equal Length Exhibit Distinct Repertoires that Differ in their Amino Acid Composition and Predicted Range of Structures", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 334, no. 4, 5 December 2003 (2003-12-05), pages 733 - 749, XP004473368, ISSN: 0022-2836 * |
Also Published As
Publication number | Publication date |
---|---|
CN101389655B (en) | 2013-05-22 |
IL192315A0 (en) | 2008-12-29 |
ES2394722T3 (en) | 2013-02-05 |
CA2634387C (en) | 2015-11-24 |
US8273688B2 (en) | 2012-09-25 |
ZA200806016B (en) | 2009-07-29 |
WO2008053275A2 (en) | 2008-05-08 |
KR20080080653A (en) | 2008-09-04 |
CN101389655A (en) | 2009-03-18 |
EP1979378A2 (en) | 2008-10-15 |
NO20083171L (en) | 2008-08-27 |
AU2006350452A1 (en) | 2008-05-08 |
CA2634387A1 (en) | 2008-05-08 |
AU2006350452B2 (en) | 2012-10-25 |
NZ569359A (en) | 2011-11-25 |
EP1979378B1 (en) | 2012-07-25 |
US20090088346A1 (en) | 2009-04-02 |
JP5405831B2 (en) | 2014-02-05 |
JP2009519727A (en) | 2009-05-21 |
DK1979378T3 (en) | 2012-10-29 |
MX2008008220A (en) | 2009-03-04 |
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