Connect public, paid and private patent data with Google Patents Public Datasets

Apparatus and method for reducing cardiac valve regurgitation

Info

Publication number
WO2008052091B1
WO2008052091B1 PCT/US2007/082461 US2007082461W WO2008052091B1 WO 2008052091 B1 WO2008052091 B1 WO 2008052091B1 US 2007082461 W US2007082461 W US 2007082461W WO 2008052091 B1 WO2008052091 B1 WO 2008052091B1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
cardiac
valve
annuloplasty
ring
annulus
Prior art date
Application number
PCT/US2007/082461
Other languages
French (fr)
Other versions
WO2008052091A2 (en )
WO2008052091A3 (en )
Inventor
Ghassan Kassab
Jose Antonio Navia
Jose Luis Navia
Original Assignee
Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2445Annuloplasty rings in direct contact with the valve annulus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2442Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466Delivery devices therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/009Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof magnetic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0001Means for transferring electromagnetic energy to implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0004Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable

Abstract

An apparatus for modifying the annulus of a cardiac valve to reduce regurgitation of blood flow through the cardiac valve includes a first aππuloplasty ring having a first diameter and being disposed about a first aspect of the annulus of the cardiac valve. The apparatus also includes an elongate flexible body having proximal and distal end portions and being iπsertable into the first annuloplasty ring. The elongate flexible body has an adjustable mechanism for selectively adjusting the elongate flexible body from a first relaxed configuration to a second tensioned configuration. The first annuloplasty ring is adaptable to obtain a second smaller diameter and to cause the annulus of the cardiac valve to be modified and reduce regurgitation of blood flow through the cardiac valve when the elongate flexible body obtains the second tensioned configuration.

Claims

37
AMENDED CLAIMS Received by the International Bureau on 21.July.2008 (21.07.08)
1. An apparatus for modifying the annulus of a cardiac valve to reduce regurgitation of blood flow through the cardiac valve, said apparatus comprising: a first annuloplasty ring having a first diameter and being disposed about a first aspect of the annulus of the cardiac valve; and an elongate flexible body comprising proximal and distal end portions and being insertable into said first annuloplasty ring, said elongate flexible body including an adjustable mechanism for selectively adjusting said elongate flexible body from a first relaxed configuration to a second tensioned configuration; said first annuloplasty ring being adaptable to obtain a second smaller diameter and to cause the annulus of the cardiac valve to be modified and reduce regurgitation of blood flow through the cardiac valve when said elongate flexible body obtains said second tensioned configuration.
2. The apparatus of claim 1, wherein said adjustment mechanism is manually manipulated so that said elongate flexible body obtains said second tensioned configuration.
3. The apparatus of claim 1 , wherein said adjustment mechanism is electromagnetically manipulated so that said elongate flexible body obtains said second tensioned configuration. 38
4. The apparatus of claim 1 , wherein a second annuloplasty ring is disposed about a second aspect of the annulus of the cardiac valve, said second annuloplasty ring being magnetically coupled to said first annuloplasty ring to secure said first annuloplasty ring about the first aspect of the annulus of the cardiac valve.
5. The apparatus of claim 1, wherein a positioning catheter is used to magnetically guide said first and/or second annuloplasty rings to the first and/or second aspects of the annulus of the cardiac valve, respectively.
11. An apparatus for modifying the annulus of a cardiac valve to reduce regurgitation of blood flow through the cardiac valve, said apparatus comprising: a first annuloplasty ring having a first diameter and being disposed about a first aspect of the annulus of the cardiac valve; and a flexible body comprising first and second oppositely disposed strut members having proximal and distal end portions and a cinching mechanism for adjusting said flexible body from a first relaxed configuration to a second tensioned configuration, said cinching mechanism being operatively connected to said distal end portion of said strut members; said cinching mechanism comprising a resistance member operatively coupled to said distal end portion of said strut members and a harness member operatively coupled to a pull wire extending between said strut members; said flexible body being disposed in a delivery catheter being ϊnsertable into said first annuloplasty ring, said delivery catheter comprising proximal and distal end portions and an opening at said distal portion for extending said harness member therethrough; said flexible body being adaptable to obtain said second tensioned configuration and to cause said first annuloplasty ring to obtain a second smaller diameter so that the annulus of the cardiac valve is modified and regurgitation of blood flow through the cardiac valve is reduced.
12. The apparatus of claim 11 , wherein a second annuloplasty ring is disposed about a second aspect of the annulus of the cardiac valve, said second anπuloplasty ring being magnetically coupled to said first annuloplasty ring so that said first annuloplasty ring is secured to the first aspect of the annulus of the cardiac valve.
13. The apparatus of claim 11 , wherein a positioning catheter is used to magnetically guide said first and/or second annuloplasty rings to the first and/or second aspects of the annulus of the cardiac valve, respectively.
18. An apparatus for modifying the annulus of a cardiac valve to reduce regurgitation of blood flow through the cardiac valve, said apparatus comprising: a first annuloplasty ring having a first diameter and being disposed about a first aspect of the annulus of the cardiac valve; and an electromagnetic wire having proximal and distal end portions, said electromagnetic wire including a plurality of magnetic members operably connected to said electromagnetic wire and an adjustable mechanism for selectively adjusting said electromagnetic wire from a first relaxed configuration to a second tensioned configuration, said electromagnetic wire being insertable into said first annuloplasty ring; said adjustable mechanism being selectively adjustable so that said first annuloplasty ring is adaptable to obtain a second smaller diameter and modify the annulus of the cardiac valve to reduce regurgitation of blood flow through the cardiac valve.
19. The apparatus of claim 18, wherein a second annuloplasty ring is disposed about a second aspect of the annuloplasty ring, said second annuloplasty ring being magnetically coupled to said first annuloplasty ring so that said first annuloplasty ring is secured to the first aspect of the annulus of the cardiac valve.
20. The apparatus of claim 19, wherein a positioning catheter is used to magnetically guide said first and/or second annuloplasty rings to the first and/or second aspects of the annulus of the cardiac valve, respectively.
PCT/US2007/082461 2005-07-15 2007-10-25 Apparatus and method for reducing cardiac valve regurgitation WO2008052091B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11586828 US7927371B2 (en) 2005-07-15 2006-01-10 Apparatus and method for reducing cardiac valve regurgitation
US11/586,828 2006-10-26

Publications (3)

Publication Number Publication Date
WO2008052091A2 true WO2008052091A2 (en) 2008-05-02
WO2008052091A3 true WO2008052091A3 (en) 2008-07-17
WO2008052091B1 true true WO2008052091B1 (en) 2008-09-04

Family

ID=39106164

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/082461 WO2008052091B1 (en) 2005-07-15 2007-10-25 Apparatus and method for reducing cardiac valve regurgitation

Country Status (2)

Country Link
US (1) US7927371B2 (en)
WO (1) WO2008052091B1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7297150B2 (en) * 2002-08-29 2007-11-20 Mitralsolutions, Inc. Implantable devices for controlling the internal circumference of an anatomic orifice or lumen
US8758372B2 (en) 2002-08-29 2014-06-24 St. Jude Medical, Cardiology Division, Inc. Implantable devices for controlling the size and shape of an anatomical structure or lumen
WO2006097931A3 (en) 2005-03-17 2007-07-26 Valtech Cardio Ltd Mitral valve treatment techniques
WO2006105084A3 (en) 2005-03-25 2007-11-29 Mitralsolutions Inc Methods and apparatus for controlling the internal circumference of an anatomic orifice or lumen
US8864823B2 (en) 2005-03-25 2014-10-21 StJude Medical, Cardiology Division, Inc. Methods and apparatus for controlling the internal circumference of an anatomic orifice or lumen
CA2671966A1 (en) 2006-12-05 2008-06-12 Valtech Cardio, Ltd. Segmented ring placement
CA2674485A1 (en) 2007-01-03 2008-07-17 Mitralsolutions, Inc. Implantable devices for controlling the size and shape of an anatomical structure or lumen
WO2009094237A1 (en) * 2008-01-23 2009-07-30 Cvdevices, Llc Devices, systems and methods for percutaneous trans-septal left atrial appendage occlusion
US8480708B2 (en) * 2007-01-23 2013-07-09 Cvdevices, Llc Devices, systems, and methods for percutaneous trans-septal left atrial appendage occlusion
US9566073B2 (en) 2007-01-23 2017-02-14 Cvdevices, Llc Devices, systems, and methods for atrial appendage occlusion
DE102007043830A1 (en) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Heart valve stent
US9192472B2 (en) 2008-06-16 2015-11-24 Valtec Cardio, Ltd. Annuloplasty devices and methods of delivery therefor
JP2011529731A (en) * 2008-07-29 2011-12-15 カートリッジ,ジョン,エフ Methods and systems for long term regulation of implantable devices
EP2358308A2 (en) * 2008-09-15 2011-08-24 Medtronic, Inc. Tools, systems, and methods for remodeling tissue
US8545553B2 (en) 2009-05-04 2013-10-01 Valtech Cardio, Ltd. Over-wire rotation tool
US9011530B2 (en) 2008-12-22 2015-04-21 Valtech Cardio, Ltd. Partially-adjustable annuloplasty structure
US8926696B2 (en) 2008-12-22 2015-01-06 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
WO2010085649A1 (en) 2009-01-22 2010-07-29 St. Jude Medical Post-operative adjustment tool, minimally invasive attachment apparatus, and adjustable tricuspid ring
WO2010091653A1 (en) * 2009-02-11 2010-08-19 Georg Lutter Catheter
US8353956B2 (en) 2009-02-17 2013-01-15 Valtech Cardio, Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
US8715342B2 (en) 2009-05-07 2014-05-06 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US9011520B2 (en) 2009-10-29 2015-04-21 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
EP2506777A4 (en) 2009-12-02 2015-02-11 Valtech Cardio Ltd Delivery tool for implantation of spool assembly coupled to a helical anchor
US9107749B2 (en) * 2010-02-03 2015-08-18 Edwards Lifesciences Corporation Methods for treating a heart
WO2012019052A3 (en) 2010-08-04 2012-07-26 Micardia Corporation Percutaneous transcatheter repair of heart valves
US8888843B2 (en) 2011-01-28 2014-11-18 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
EP2484310A1 (en) * 2011-02-08 2012-08-08 Biotronik AG Heart valve prosthesis with flexible fixations and deployment device therefor
US9402721B2 (en) 2011-06-01 2016-08-02 Valcare, Inc. Percutaneous transcatheter repair of heart valves via trans-apical access
US9480559B2 (en) 2011-08-11 2016-11-01 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US8858623B2 (en) * 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
EP2775896A4 (en) 2011-11-08 2016-08-03 Valtech Cardio Ltd Controlled steering functionality for implant-delivery tool
US9827092B2 (en) 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US9180008B2 (en) 2012-02-29 2015-11-10 Valcare, Inc. Methods, devices, and systems for percutaneously anchoring annuloplasty rings
US9839519B2 (en) 2012-02-29 2017-12-12 Valcare, Inc. Percutaneous annuloplasty system with anterior-posterior adjustment
WO2014021905A1 (en) 2012-07-30 2014-02-06 Tendyne Holdings, Inc. Improved delivery systems and methods for transcatheter prosthetic valves
WO2014080338A1 (en) * 2012-11-20 2014-05-30 Ht Consultant Di Giovanni Righini Device for the deployment of a system of guide wires within a cardiac chamber for implanting a prosthetic heart valve
CA2922899A1 (en) * 2012-11-20 2014-05-30 Innovheart S.R.L. Prosthetic system for heart valve replacement
US9730793B2 (en) 2012-12-06 2017-08-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
US20150351911A1 (en) * 2013-01-25 2015-12-10 Medtentia International Ltd Oy A Medical Device And Method For Facilitating Selection Of An Annuloplasty Implant
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
CN105658178A (en) 2013-06-25 2016-06-08 坦迪尼控股股份有限公司 Thrombus management and structural compliance features for prosthetic heart valves
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
US9592121B1 (en) 2015-11-06 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valvular regurgitation

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6217610B1 (en) * 1994-07-29 2001-04-17 Edwards Lifesciences Corporation Expandable annuloplasty ring
DE69630235D1 (en) 1995-12-01 2003-11-06 Medtronic Inc Prothese für anuloplastie
US6250308B1 (en) 1998-06-16 2001-06-26 Cardiac Concepts, Inc. Mitral valve annuloplasty ring and method of implanting
WO2000060995A9 (en) 1999-04-09 2002-06-13 Evalve Inc Methods and apparatus for cardiac valve repair
US6810882B2 (en) 2001-01-30 2004-11-02 Ev3 Santa Rosa, Inc. Transluminal mitral annuloplasty
US7011682B2 (en) 2000-01-31 2006-03-14 Edwards Lifesciences Ag Methods and apparatus for remodeling an extravascular tissue structure
US6569198B1 (en) 2000-03-31 2003-05-27 Richard A. Wilson Mitral or tricuspid valve annuloplasty prosthetic device
US6805711B2 (en) 2000-06-02 2004-10-19 3F Therapeutics, Inc. Expandable medical implant and percutaneous delivery
US6419696B1 (en) 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
US20060069429A1 (en) 2001-04-24 2006-03-30 Spence Paul A Tissue fastening systems and methods utilizing magnetic guidance
US6726716B2 (en) 2001-08-24 2004-04-27 Edwards Lifesciences Corporation Self-molding annuloplasty ring
JP4230915B2 (en) 2001-12-21 2009-02-25 シムチャ ミロ Transplant system for the annuloplasty ring
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US20030199974A1 (en) 2002-04-18 2003-10-23 Coalescent Surgical, Inc. Annuloplasty apparatus and methods
US20040243227A1 (en) 2002-06-13 2004-12-02 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US7485143B2 (en) 2002-11-15 2009-02-03 Abbott Cardiovascular Systems Inc. Apparatuses and methods for heart valve repair
US6974476B2 (en) 2003-05-05 2005-12-13 Rex Medical, L.P. Percutaneous aortic valve
US7753922B2 (en) 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Devices and methods for cardiac annulus stabilization and treatment
US20060184242A1 (en) 2003-10-20 2006-08-17 Samuel Lichtenstein Method and apparatus for percutaneous reduction of anterior-posterior diameter of mitral valve
WO2005046488A3 (en) 2003-11-12 2005-11-24 David D Barone Cardiac valve annulus reduction system
US7166127B2 (en) 2003-12-23 2007-01-23 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
US8206439B2 (en) 2004-02-23 2012-06-26 International Heart Institute Of Montana Foundation Internal prosthesis for reconstruction of cardiac geometry
US7361190B2 (en) 2004-06-29 2008-04-22 Micardia Corporation Adjustable cardiac valve implant with coupling mechanism
US20060015178A1 (en) 2004-07-15 2006-01-19 Shahram Moaddeb Implants and methods for reshaping heart valves

Also Published As

Publication number Publication date Type
WO2008052091A2 (en) 2008-05-02 application
WO2008052091A3 (en) 2008-07-17 application
US7927371B2 (en) 2011-04-19 grant
US20070233239A1 (en) 2007-10-04 application

Similar Documents

Publication Publication Date Title
WO2007080974A1 (en) Treatment endoscope
WO2006100658A3 (en) A surgical instrument
WO2008028135A3 (en) Method and apparatus for tissue connection
WO2004032799A3 (en) Implantable medical devices
WO2007121405A3 (en) System and method for mechanically positioning intravascular implants
WO2008068756A3 (en) Segmented ring placement
WO2006104143A1 (en) Body organ expansion instrument
WO2008001882A1 (en) Medical holder and method of using the medical holder
WO2004112585A3 (en) Valve annulus reduction system
WO2006054107A3 (en) Method and apparatus for treatment of cardiac valves
WO2008021994A3 (en) Apparatus and methods for delivering stem cells and other agents into cardiac tissue
WO2007055032A1 (en) Method of endoscopical diagnosis or treatment and medical device
USD602158S1 (en) Butterfly flange
US20090084389A1 (en) Apparatus and Method for Securing Uvula
CN201282980Y (en) Vertebra expanding and filling device
WO2004112888A3 (en) Therapeutic ultrasound system
WO2006129441A1 (en) Stent deployment device
FR2856582A1 (en) Artificial sphincter for urinary incontinence treatment, has band including inflatable cuff engaged beneath urethra, lateral parts linked to lateral anatomical structures, and cuff inflating device inflating and deflating cuff
WO2005099628A3 (en) Implantable frame with variable compliance
CN202590135U (en) Intracolonic three-cavity air bag enclosed drainage tube assembly
WO2007075394A3 (en) Tissue augmentation device
WO2004047677A3 (en) Methods and apparatus for remodeling an extravascular tissue structure
WO2007008371A3 (en) Prosthetic mitral heart valve having a contoured sewing ring
DE102004015720A1 (en) Surgical set, in particular, for gynecological operations comprises needle which close to its point is provided with a holding device for a nonresorptive net-like band
WO2005016427A3 (en) Improved airway device

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07844597

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07844597

Country of ref document: EP

Kind code of ref document: A2