WO2008043791A3 - Thiophene derivatives for treating hepatitis c - Google Patents

Thiophene derivatives for treating hepatitis c Download PDF

Info

Publication number
WO2008043791A3
WO2008043791A3 PCT/EP2007/060779 EP2007060779W WO2008043791A3 WO 2008043791 A3 WO2008043791 A3 WO 2008043791A3 EP 2007060779 W EP2007060779 W EP 2007060779W WO 2008043791 A3 WO2008043791 A3 WO 2008043791A3
Authority
WO
WIPO (PCT)
Prior art keywords
treating hepatitis
thiophene derivatives
thiophene
derivatives
hepatitis
Prior art date
Application number
PCT/EP2007/060779
Other languages
French (fr)
Other versions
WO2008043791A2 (en
Inventor
Charles David Hartley
Jacqueline Elizabeth Mordaunt
Pritom Shah
Martin John Slater
Gemma Victoria White
Original Assignee
Smithkline Beecham Corp
Charles David Hartley
Jacqueline Elizabeth Mordaunt
Pritom Shah
Martin John Slater
Gemma Victoria White
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0620399A external-priority patent/GB0620399D0/en
Priority claimed from GB0709629A external-priority patent/GB0709629D0/en
Application filed by Smithkline Beecham Corp, Charles David Hartley, Jacqueline Elizabeth Mordaunt, Pritom Shah, Martin John Slater, Gemma Victoria White filed Critical Smithkline Beecham Corp
Publication of WO2008043791A2 publication Critical patent/WO2008043791A2/en
Publication of WO2008043791A3 publication Critical patent/WO2008043791A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Anti-viral agents of compounds of Formula (I) : wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.
PCT/EP2007/060779 2006-10-13 2007-10-10 Thiophene derivatives for treating hepatitis c WO2008043791A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0620399.6 2006-10-13
GB0620399A GB0620399D0 (en) 2006-10-13 2006-10-13 Compounds
GB0709629.0 2007-05-18
GB0709629A GB0709629D0 (en) 2007-05-18 2007-05-18 Compounds

Publications (2)

Publication Number Publication Date
WO2008043791A2 WO2008043791A2 (en) 2008-04-17
WO2008043791A3 true WO2008043791A3 (en) 2008-06-05

Family

ID=39004831

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/060779 WO2008043791A2 (en) 2006-10-13 2007-10-10 Thiophene derivatives for treating hepatitis c

Country Status (1)

Country Link
WO (1) WO2008043791A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0712393D0 (en) * 2007-06-26 2007-08-01 Smithkline Beecham Corp Compounds
JP5690286B2 (en) 2009-03-04 2015-03-25 イデニク プハルマセウティカルス，インコーポレイテッド Phosphothiophene and phosphothiazole HCV polymerase inhibitors
AU2011305652B2 (en) 2010-09-22 2016-10-20 Janssen Biopharma, Inc. Azido nucleosides and nucleotide analogs
TW201307334A (en) 2010-12-17 2013-02-16 Cocrystal Discovery Inc Inhibitors of hepatitis C virus polymerase
WO2014055142A1 (en) 2012-06-20 2014-04-10 Cocrystal Discovery, Inc. Inhibitors of hepatitis c virus polymerase
TWI731854B (en) 2015-03-23 2021-07-01 美商共結晶製藥公司 Inhibitors of hepatitis c virus polymerase
JP7381493B2 (en) 2018-05-09 2023-11-15 コクリスタル ファーマ，インコーポレイテッド Combination therapy to treat HCV

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100851A2 (en) * 2001-06-11 2002-12-19 Shire Biochem Inc. Thiophene derivatives as antiviral agents for flavivirus infection
WO2004052879A1 (en) * 2002-12-10 2004-06-24 Virochem Pharma Inc. Thiophenederivatives for the treatment of flavivirus infections
WO2004052885A1 (en) * 2002-12-10 2004-06-24 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
WO2005063734A2 (en) * 2003-12-19 2005-07-14 Aicuris Gmbh & Co. Kg Substituted thiophenes
WO2007071434A1 (en) * 2005-12-22 2007-06-28 Smithkline Beecham Corporation Antiviral 2-carboxy-thiophene compounds
WO2007088148A1 (en) * 2006-02-01 2007-08-09 Smithkline Beecham Corporation Derivatives of thiophene carboxilic acid as antiviral agent
WO2007147794A1 (en) * 2006-06-19 2007-12-27 Smithkline Beecham Corporation Furan derivatives and their use as antiviral agents

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100851A2 (en) * 2001-06-11 2002-12-19 Shire Biochem Inc. Thiophene derivatives as antiviral agents for flavivirus infection
WO2004052879A1 (en) * 2002-12-10 2004-06-24 Virochem Pharma Inc. Thiophenederivatives for the treatment of flavivirus infections
WO2004052885A1 (en) * 2002-12-10 2004-06-24 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
WO2005063734A2 (en) * 2003-12-19 2005-07-14 Aicuris Gmbh & Co. Kg Substituted thiophenes
WO2007071434A1 (en) * 2005-12-22 2007-06-28 Smithkline Beecham Corporation Antiviral 2-carboxy-thiophene compounds
WO2007088148A1 (en) * 2006-02-01 2007-08-09 Smithkline Beecham Corporation Derivatives of thiophene carboxilic acid as antiviral agent
WO2007147794A1 (en) * 2006-06-19 2007-12-27 Smithkline Beecham Corporation Furan derivatives and their use as antiviral agents

Also Published As

Publication number Publication date
WO2008043791A2 (en) 2008-04-17

Similar Documents

Publication Publication Date Title
TW200800969A (en) Compounds
ATE524465T1 (en) 2-CARBOXY-THIOPHENE DERIVATIVES AS VIRUCIDES
TW200728317A (en) Macrocylic inhibitors of hepatitis C virus
IL189694A0 (en) Biphenyl derivatives and their use in treating hepatitis c
WO2008142055A3 (en) Antiviral agents
WO2008043791A3 (en) Thiophene derivatives for treating hepatitis c
WO2007120595A3 (en) Amines for the treatment of hcv
WO2008147557A3 (en) Heteroaryl substituted thiazoles and their use as antiviral agents
WO2008062376A3 (en) New process for the preparation of 2-imino-thiazolidin-4-one derivatives
WO2011068941A3 (en) Proline derivatives
WO2006027628A3 (en) Naphthalimide derivatives as antiviral agents
WO2006072347A3 (en) Alkinyl-substituted thiophenes
NO345018B1 (en) Process for the preparation of organofluoro compounds in alcoholic solvents.
WO2007019397A3 (en) 6-membered aryl and heteroaryl derivatives for the treatment of hepatitis c virus
WO2007029029A3 (en) Tetracyclic indole derivatives as antiviral agents
WO2008054454A3 (en) Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents
WO2008075068A3 (en) Acylaminopyrazoles as fgfr inhibitors
RS50815B (en) Fused heterotetracyclic compunds and use thereof as hcv polymerase inhibitor
WO2007015017A3 (en) Novel polyquinoline derivatives and the therapeutic use thereof
WO2006124861A3 (en) Benzofuran compounds
WO2009055335A3 (en) Hcv protease inhibitors
WO2007041632A3 (en) Methods and pharmaceutical compositions for the treatment and prevention of hepatitis c infection
WO2008048589A3 (en) Compounds and methods for treatment of hcv
WO2009026166A3 (en) Antiinfective flavonol compounds and methods of use thereof
WO2008133669A3 (en) Viral inhibitors

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07821147

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2009117568

Country of ref document: RU

Kind code of ref document: A

122 Ep: pct application non-entry in european phase

Ref document number: 07821147

Country of ref document: EP

Kind code of ref document: A2