WO2008037700A3 - Methods for breast cancer prognosis - Google Patents

Methods for breast cancer prognosis Download PDF

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Publication number
WO2008037700A3
WO2008037700A3 PCT/EP2007/060143 EP2007060143W WO2008037700A3 WO 2008037700 A3 WO2008037700 A3 WO 2008037700A3 EP 2007060143 W EP2007060143 W EP 2007060143W WO 2008037700 A3 WO2008037700 A3 WO 2008037700A3
Authority
WO
WIPO (PCT)
Prior art keywords
breast cancer
methods
prognosis
patients
cancer prognosis
Prior art date
Application number
PCT/EP2007/060143
Other languages
French (fr)
Other versions
WO2008037700A2 (en
Inventor
Mathias Gehrmann
Toerne Christian Von
Original Assignee
Siemens Medical Solutions Diag
Mathias Gehrmann
Toerne Christian Von
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Medical Solutions Diag, Mathias Gehrmann, Toerne Christian Von filed Critical Siemens Medical Solutions Diag
Priority to US12/441,748 priority Critical patent/US20090311700A1/en
Priority to EP07820546.5A priority patent/EP2066805B1/en
Publication of WO2008037700A2 publication Critical patent/WO2008037700A2/en
Publication of WO2008037700A3 publication Critical patent/WO2008037700A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to methods, kits and systems for the prognosis of the disease outcome of breast cancer in untreated breast cancer patients. More specific, the present invention relates to the prognosis of breast cancer based on measurements of the expression levels of marker genes in tumor samples of breast cancer patients. Marker genes are disclosed which allow for an accurate prognosis of breast cancer in patients having node negative, fast proliferating breast cancer.
PCT/EP2007/060143 2006-09-27 2007-09-25 Methods for breast cancer prognosis WO2008037700A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/441,748 US20090311700A1 (en) 2006-09-27 2007-09-25 Methods for Breast Cancer Prognosis
EP07820546.5A EP2066805B1 (en) 2006-09-27 2007-09-25 Methods for breast cancer prognosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06020209 2006-09-27
EP06020209.0 2006-09-27

Publications (2)

Publication Number Publication Date
WO2008037700A2 WO2008037700A2 (en) 2008-04-03
WO2008037700A3 true WO2008037700A3 (en) 2008-07-03

Family

ID=38926441

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/060143 WO2008037700A2 (en) 2006-09-27 2007-09-25 Methods for breast cancer prognosis

Country Status (3)

Country Link
US (1) US20090311700A1 (en)
EP (2) EP3135773A1 (en)
WO (1) WO2008037700A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960114B2 (en) 2007-05-02 2011-06-14 Siemens Medical Solutions Usa, Inc. Gene signature of early hypoxia to predict patient survival
US20080286273A1 (en) * 2007-05-02 2008-11-20 Siemens Medical Solutions Usa, Inc. Knowledge-Based Proliferation Signatures and Methods of Use
EP2389448A1 (en) * 2009-01-21 2011-11-30 Universita' Degli Studi Di Padova Prognosis of breast cancer patients by monitoring the expression of two genes
US8597885B2 (en) 2009-01-28 2013-12-03 University Of Notre Dame Accelerated progression relapse test
US20120149594A1 (en) * 2010-12-10 2012-06-14 Nuclea Biotechnologies, Inc. Biomarkers for prediction of breast cancer
JP2014221065A (en) * 2014-07-07 2014-11-27 ユニヴァーシタ デグリ ステューディ ディ パドヴァ Prognosis of breast cancer patient by observation of expression of two genes
EP3202913B1 (en) * 2016-02-08 2019-01-30 King Faisal Specialist Hospital And Research Centre A set of genes for use in a method of predicting the likelihood of a breast cancer patient's survival
EP3260552A1 (en) * 2016-06-20 2017-12-27 Istituto Europeo di Oncologia (IEO) Methods and kits comprising gene signatures for stratifying breast cancer patients
KR101950717B1 (en) * 2016-11-23 2019-02-21 주식회사 젠큐릭스 Methods for predicting effectiveness of chemotherapy for breast cancer patients
KR102422610B1 (en) * 2020-05-12 2022-07-18 서울대학교 산학협력단 Methods for predicting prognosis in early breast cancer patients
CN117607442B (en) * 2024-01-23 2024-04-16 杭州华得森生物技术有限公司 Marker for predicting breast cancer immunotherapy effect, kit and application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7171311B2 (en) * 2001-06-18 2007-01-30 Rosetta Inpharmatics Llc Methods of assigning treatment to breast cancer patients
US7354705B2 (en) 2003-01-30 2008-04-08 Schering Corporation Methods for cancer prognosis and diagnosis
JP4579246B2 (en) * 2003-09-24 2010-11-10 オンコセラピー・サイエンス株式会社 How to diagnose breast cancer
ATE550440T1 (en) * 2004-11-05 2012-04-15 Genomic Health Inc MOLECULAR INDICATORS FOR BREAST CANCER PROGNOSIS AND PREDICTION OF TREATMENT RESPONSE
WO2006084272A2 (en) * 2005-02-04 2006-08-10 Rosetta Inpharmatics Llc Methods of predicting chemotherapy responsiveness in breast cancer patients

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
LUBOSHITS GALIA ET AL: "Elevated expression of the CC chemokine Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) in advanced breast carcinoma", CANCER RESEARCH, vol. 59, no. 18, 15 September 1999 (1999-09-15), pages 4681 - 4687, XP002467110, ISSN: 0008-5472 *
NIWA Y ET AL: "Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH FEB 2001, vol. 7, no. 2, February 2001 (2001-02-01), pages 285 - 289, XP002467109, ISSN: 1078-0432 *
NUYTEN DIMITRY S A ET AL: "Gene expression signatures to predict the development of metastasis in breast cancer.", BREAST DISEASE 2006-2007, vol. 26, 23 April 2007 (2007-04-23), pages 149 - 156, XP009095049, ISSN: 0888-6008 *
POCKAJ BARBARA A ET AL: "Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancer.", ANNALS OF SURGICAL ONCOLOGY MAR 2004, vol. 11, no. 3, March 2004 (2004-03-01), pages 328 - 339, XP002467000, ISSN: 1068-9265 *
VEER VAN 'T L ET AL: "Gene expression profiling predicts clinical outcome of breast cancer", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 415, 2002, pages 530 - 536, XP002404599, ISSN: 0028-0836 *
WANG Y ET AL: "Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer", LANCET THE, LANCET LIMITED. LONDON, GB, vol. 365, no. 9460, 19 February 2005 (2005-02-19), pages 671 - 679, XP004758006, ISSN: 0140-6736 *

Also Published As

Publication number Publication date
EP2066805A2 (en) 2009-06-10
WO2008037700A2 (en) 2008-04-03
EP2066805B1 (en) 2016-07-27
EP3135773A1 (en) 2017-03-01
US20090311700A1 (en) 2009-12-17

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