WO2008024495A3 - Biomarkers associated with age-related macular degeneration - Google Patents

Biomarkers associated with age-related macular degeneration Download PDF

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Publication number
WO2008024495A3
WO2008024495A3 PCT/US2007/018785 US2007018785W WO2008024495A3 WO 2008024495 A3 WO2008024495 A3 WO 2008024495A3 US 2007018785 W US2007018785 W US 2007018785W WO 2008024495 A3 WO2008024495 A3 WO 2008024495A3
Authority
WO
WIPO (PCT)
Prior art keywords
amd
age
macular degeneration
related macular
biomarkers associated
Prior art date
Application number
PCT/US2007/018785
Other languages
French (fr)
Other versions
WO2008024495A2 (en
Inventor
Gregory S Hagerman
Original Assignee
Univ Iowa Res Found
Gregory S Hagerman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Iowa Res Found, Gregory S Hagerman filed Critical Univ Iowa Res Found
Priority to CA002661161A priority Critical patent/CA2661161A1/en
Priority to EP07837342A priority patent/EP2054728A2/en
Priority to US12/438,512 priority patent/US20100248263A1/en
Publication of WO2008024495A2 publication Critical patent/WO2008024495A2/en
Publication of WO2008024495A3 publication Critical patent/WO2008024495A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G01N2800/164—Retinal disorders, e.g. retinopathy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to proteins associated with age-related macular degeneration (AMD). These proteins, which are present in blood, are expressed in individuals with AMD at either elevated or reduced levels compared to healthy individuals. The invention provides methods for diagnosing AMD. The invention provides methods for assessing the efficacy of treatment of AMD. The invention provides methods for monitoring the progression of AMD.
PCT/US2007/018785 2006-08-23 2007-08-23 Biomarkers associated with age-related macular degeneration WO2008024495A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002661161A CA2661161A1 (en) 2006-08-23 2007-08-23 Biomarkers associated with age-related macular degeneration
EP07837342A EP2054728A2 (en) 2006-08-23 2007-08-23 Biomarkers associated with age-related macular degeneration
US12/438,512 US20100248263A1 (en) 2006-08-23 2007-08-23 Biomarkers associated with age-related macular degeneration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83982306P 2006-08-23 2006-08-23
US60/839,823 2006-08-23

Publications (2)

Publication Number Publication Date
WO2008024495A2 WO2008024495A2 (en) 2008-02-28
WO2008024495A3 true WO2008024495A3 (en) 2008-05-29

Family

ID=38754743

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018785 WO2008024495A2 (en) 2006-08-23 2007-08-23 Biomarkers associated with age-related macular degeneration

Country Status (4)

Country Link
US (1) US20100248263A1 (en)
EP (1) EP2054728A2 (en)
CA (1) CA2661161A1 (en)
WO (1) WO2008024495A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103920142A (en) * 2005-02-14 2014-07-16 爱荷华大学研究基金会 Methods And Reagents For Treatment Of Age-related Macular Degeneration
CA2621953A1 (en) * 2005-09-09 2007-03-22 University Of Iowa Research Foundation Biomarkers associated with age-related macular degeneration
JP6274567B2 (en) 2014-03-14 2018-02-07 キヤノン株式会社 Solid-state imaging device and imaging system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050287601A1 (en) * 2000-02-22 2005-12-29 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60136272D1 (en) * 2000-04-29 2008-12-04 Univ Iowa Res Found DIAGNOSTICS AND THERAPEUTICS FOR MACULAR DEGENERATION DISEASES
US20050112706A1 (en) * 2002-11-07 2005-05-26 Susan Kasper Diagnostic and prognostic methods for prostate cancers
US7309487B2 (en) * 2004-02-09 2007-12-18 George Inana Methods and compositions for detecting and treating retinal diseases
WO2005083430A1 (en) * 2004-02-25 2005-09-09 Massachusetts Eye & Ear Infirmary Biomarkers for age-related macular degeneration (amd)
CN103920142A (en) * 2005-02-14 2014-07-16 爱荷华大学研究基金会 Methods And Reagents For Treatment Of Age-related Macular Degeneration
AU2006254979B2 (en) * 2005-06-08 2011-11-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Susceptibility genes for age-related maculopathy (ARM) on chromosome 10q26
CA2621953A1 (en) * 2005-09-09 2007-03-22 University Of Iowa Research Foundation Biomarkers associated with age-related macular degeneration
WO2007118095A2 (en) * 2006-04-03 2007-10-18 University Of Iowa Research Foundation Binding of complement factor h to c-reactive protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050287601A1 (en) * 2000-02-22 2005-12-29 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DASCH BURKHARD ET AL: "Inflammatory markers in age-related maculopathy - Cross-sectional analysis from the Muenster Aging and Retina Study", ARCHIVES OF OPHTHALMOLOGY, vol. 123, no. 11, November 2005 (2005-11-01), pages 1501 - 1506, XP009093447, ISSN: 0003-9950 *
SEDDON J M ET AL: "PROGRESSION OF AGE-RELATED MACULAR DEGENERATION", ARCHIVES OF OPHTHALMOLOGY, XX, XX, vol. 123, June 2005 (2005-06-01), pages 774 - 782, XP009068012, ISSN: 0003-9950 *

Also Published As

Publication number Publication date
CA2661161A1 (en) 2008-02-28
EP2054728A2 (en) 2009-05-06
US20100248263A1 (en) 2010-09-30
WO2008024495A2 (en) 2008-02-28

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