WO2008020305A3 - Formes pharmaceutiques solides des acides bisphosphoniques - Google Patents

Formes pharmaceutiques solides des acides bisphosphoniques Download PDF

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Publication number
WO2008020305A3
WO2008020305A3 PCT/IB2007/002440 IB2007002440W WO2008020305A3 WO 2008020305 A3 WO2008020305 A3 WO 2008020305A3 IB 2007002440 W IB2007002440 W IB 2007002440W WO 2008020305 A3 WO2008020305 A3 WO 2008020305A3
Authority
WO
WIPO (PCT)
Prior art keywords
dosage forms
solid dosage
bisphosphonic acids
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
PCT/IB2007/002440
Other languages
English (en)
Other versions
WO2008020305A2 (fr
Inventor
Ramesh Babu Batta
Umesh Nandkumar Khatavkar
Hidaytulla Shamshuddin Aga
Kishor Dattatray Deo
Sivakumaran Meenakshisunderam
Original Assignee
Aurobindo Pharma Ltd
Ramesh Babu Batta
Umesh Nandkumar Khatavkar
Hidaytulla Shamshuddin Aga
Kishor Dattatray Deo
Sivakumaran Meenakshisunderam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Ltd, Ramesh Babu Batta, Umesh Nandkumar Khatavkar, Hidaytulla Shamshuddin Aga, Kishor Dattatray Deo, Sivakumaran Meenakshisunderam filed Critical Aurobindo Pharma Ltd
Publication of WO2008020305A2 publication Critical patent/WO2008020305A2/fr
Publication of WO2008020305A3 publication Critical patent/WO2008020305A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des formes pharmaceutiques orales d'un acide bisphosphonique ou de ses sels pharmaceutiquement acceptables. La présente invention concerne plus particulièrement des formes pharmaceutiques orales d'un acide bisphosphonique ou de ses sels pharmaceutiquement acceptables préparées par un procédé de granulation par voie humide.
PCT/IB2007/002440 2006-08-17 2007-08-13 Formes pharmaceutiques solides des acides bisphosphoniques WO2008020305A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1448/CHE/2006 2006-08-17
IN1448CH2006 2006-08-17

Publications (2)

Publication Number Publication Date
WO2008020305A2 WO2008020305A2 (fr) 2008-02-21
WO2008020305A3 true WO2008020305A3 (fr) 2008-05-08

Family

ID=39027470

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/002440 WO2008020305A2 (fr) 2006-08-17 2007-08-13 Formes pharmaceutiques solides des acides bisphosphoniques

Country Status (1)

Country Link
WO (1) WO2008020305A2 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681590A (en) * 1992-12-02 1997-10-28 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US20030203878A1 (en) * 2000-06-23 2003-10-30 Moshe Flashner-Barak Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
EP1407766A2 (fr) * 2002-10-07 2004-04-14 Verisfield (UK) Ltd. Compositions pharmaceutiques contenant un sel d'acide alendronique
WO2005030177A2 (fr) * 2003-09-29 2005-04-07 Cipla Limited Formulation pharmaceutique a stabilite amelioree
WO2006046100A1 (fr) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Composition pharmaceutique a base d'acide alendronique
WO2006054165A1 (fr) * 2004-11-19 2006-05-26 Ranbaxy Laboratories Limited Compositions pharmaceutiques de l'acide alendronique et leur procede de preparation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681590A (en) * 1992-12-02 1997-10-28 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US20030203878A1 (en) * 2000-06-23 2003-10-30 Moshe Flashner-Barak Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
EP1407766A2 (fr) * 2002-10-07 2004-04-14 Verisfield (UK) Ltd. Compositions pharmaceutiques contenant un sel d'acide alendronique
WO2005030177A2 (fr) * 2003-09-29 2005-04-07 Cipla Limited Formulation pharmaceutique a stabilite amelioree
WO2006046100A1 (fr) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Composition pharmaceutique a base d'acide alendronique
WO2006054165A1 (fr) * 2004-11-19 2006-05-26 Ranbaxy Laboratories Limited Compositions pharmaceutiques de l'acide alendronique et leur procede de preparation

Also Published As

Publication number Publication date
WO2008020305A2 (fr) 2008-02-21

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