WO2008004186A1 - Method and use of a printer device for producing biological test arrays - Google Patents
Method and use of a printer device for producing biological test arrays Download PDFInfo
- Publication number
- WO2008004186A1 WO2008004186A1 PCT/IB2007/052591 IB2007052591W WO2008004186A1 WO 2008004186 A1 WO2008004186 A1 WO 2008004186A1 IB 2007052591 W IB2007052591 W IB 2007052591W WO 2008004186 A1 WO2008004186 A1 WO 2008004186A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nozzle
- printer device
- substrate
- biological test
- depositing
- Prior art date
Links
- 238000012360 testing method Methods 0.000 title claims abstract description 35
- 238000003491 array Methods 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims abstract description 12
- 239000000758 substrate Substances 0.000 claims abstract description 55
- 238000000151 deposition Methods 0.000 claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 claims abstract description 18
- 239000012530 fluid Substances 0.000 claims description 42
- 238000001514 detection method Methods 0.000 claims description 29
- 230000007547 defect Effects 0.000 claims description 20
- 230000003287 optical effect Effects 0.000 claims description 16
- 238000013139 quantization Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 description 13
- 238000007639 printing Methods 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241000233866 Fungi Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000004544 DNA amplification Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000001215 fluorescent labelling Methods 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/0036—Nozzles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00378—Piezoelectric or ink jet dispensers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00693—Means for quality control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
- G01N2035/1076—Multiple transfer devices plurality or independently movable heads
Definitions
- the invention relates to a printer device for producing biological test arrays by depositing an array of bio fluids onto a substrate.
- the invention further relates to the use of such a device in the production of biological test arrays.
- the invention also relates to a method for producing a biological test array.
- the invention moreover relates to a biological test array.
- Arrays of bio fluids on a substrate are used in biological test assays, for instance for the analysis of human blood or tissue samples for the presence of certain bacteria, viruses or fungi.
- the arrays consist of spots with a selective binding capacity for a predetermined indicative factor, such as a protein, DNA or RNA sequence that belongs to a specific bacterium, virus or fungus. By having spots with different specificity for different factors, the array may be used to assay for various different factors at the same time. The presence of an indicative factor may be visualized for instance by fluorescent labeling of the tested sample, which results in a detectable fluorescence on the spot the specific factor adheres to. Using such arrays enables high-throughput screening of samples for a large amount of factors indicative of certain bacteria, viruses and/or fungi in a single run.
- the spots are printed onto a substrate such as a membrane, by applying bio fluids that contain the specific indicative factor.
- a suitable bio fluid may for instance be a solution of a specific DNA sequence or antibody.
- the printing is usually done by a printing device especially designed for depositing bio fluids on a substrate, usually by a different print head for each different bio fluid to be included in the array.
- Such print heads are however prone to failure resulting in unreliable tests, for instance by missing spots in the array on substrate, or in spots that do not contain the predetermined amount of bio fluid,. Missing spots can not be detected, resulting in a negative result even in case the factor to be determined by the missing spot is actually present in a sample.
- Spots with a lacking amount of bio fluid may result in a lower detected level for that spot, which could lead to false results indicating a lower level of the specific factor in the tested sample than the actual level, or in a negative result in case the detected level drops under a predetermined threshold level, referred to as a false negative result.
- the invention provides a printer device for producing biological test arrays by depositing an array of biofluids onto a substrate, the device comprising at least one print head provided with at least one primary nozzle for depositing a droplet of a bio fluid onto the substrate, positioning means for positioning the print head relative to the substrate, detection means for detecting defects in the depositing by the primary nozzle, and control means connected to the detection means and the positioning means, wherein for each primary nozzle dedicated to a specific bio fluid the printer device comprises at least one secondary nozzle dedicated to the same specific bio fluid, and wherein the control means are programmed to use the secondary nozzle if a predetermined defect in the depositing by the first nozzle is detected by the detection means.
- Such a printer device is capable of producing biological test arrays with fewer defects. Also, with such a device higher production rates can be achieved, as less time is wasted in changing print heads in case of a malfunctioning nozzle, as such defects are immediately registered by the printer device and overcome by use of the secondary nozzle. Another time-saving factor is that quality control after production is less time-consuming, as the improved printer ensures that the number of misprinted biological test arrays is minimalized.
- the print head and the nozzles are especially adapted for depositing biofluids.
- biofluid covers fluids that contain the biological binding substances such as DNA sequences or antibodies that is used to specifically bind certain biomolecules in a sample on the substrate.
- a printer head may have multiple nozzles.
- the positioning means are designed for moving and transporting one or more pint heads and/or substrates, in order to position a specific nozzle over the exact location of the substrate, in order to deposit a droplet of biofluid on exactly the desired position.
- Detection means for detecting defects in the depositing by the primary nozzle may be based on any physical characteristics of the printing process.
- the control means usually involve a microprocessor connected to the detection means and the positioning means, and contains the necessary information to produce the predetermined array of biofluids on the substrate, in particular the positions of the nozzles and the substrate.
- the position of each nozzle and the exact location where a spot from a specific biofluid printer head is to be deposited are monitored by the control means.
- the secondary nozzle, or back-up nozzle is dedicated to the same specific biofluid as one of the primary nozzles. Thus, the secondary nozzle may correct any detected failure or mistake by the primary nozzle, without having to stop the production process and replace the first nozzle.
- the primary nozzle and at least one secondary nozzle are located on the same print head.
- the primary nozzle and at least one secondary nozzle are located on the same print head.
- the primary nozzle and at least one secondary nozzle are located on different print heads.
- Such a configuration makes it easier to maintain or replace the print head on which the primary nozzle is located while the secondary nozzle is carrying out the production process. Thus, the interruption of the production process is minimized.
- At least one secondary nozzle is located on the same print head as the primary nozzle and at least one secondary nozzle is located on at least one different print head.
- the device comprises multiple print heads. Multiple print heads enable an optimal work flow.
- Each print head may comprise nozzles for different biofluids. However, preferably each print head is dedicated to a single bio fluid. This allows for a simpler construction and easier replacement of the print head.
- the device comprises multiple secondary nozzles. Multiple secondary nozzles allow to continue the production process even if one or more nozzles are being maintained or replaced. Thus, the down time of the device can me minimized.
- the device comprises multiple print heads grouped together in an array, wherein the array comprises at least one nozzle for each different bio fluid to be applied. In case a large number of different fluids have to be printed, groups of print heads may be arranged in multiple arrays. Each array of print heads forms an independently operable unit.
- the device comprises multiple identical arrays. Such arrays of print heads are mutually exchangeable, allowing for a flexible work method.
- the detection means comprise an optical sensor.
- Optical sensors are reliable and sensitive.
- the optical sensor is preferably adapted to quantize the amount of deposited bio fluid on the substrate.
- the device may comprise multiple optical sensors dedicated to the same or to different detection methods.
- the optical sensor may be combined with other detection means, such as an acoustical sensor.
- the detection means comprise an acoustical sensor.
- the acoustical sensor may be adapted to determine the amount of bio fluid deposited by the nozzle.
- the acoustical sensor may be combined with other detection means, such as an optical sensor.
- the detection means are adapted to measuring an acoustical or optical characteristic of the nozzle, and wherein the control means are programmed to determine a defect by comparison of the measured characteristic of the nozzle with a predetermined characteristic of the nozzle.
- the detection means and control means are adapted to quantize the amount of bio fluid deposited by the nozzle, for instance by a predetermined relationship between the deposited amount of biofluid and the measured characteristic.
- a backlight is located underneath an optically transparent substrate such as a membrane.
- a droplet of biofluid When a droplet of biofluid is deposited on the substrate by a first nozzle, during a short period of time, this droplet is detectable as an optical contrast with the membrane that may be quantized by a camera.
- the spots detected on the substrate are compared to the predetermined pattern as programmed. If spots are missing, or spots are lacking in the amount of biofluid deposited, the second nozzle is activated to correct these errors. The detection of an error may also trigger the cleaning or the deactivation of the malfunctioning first nozzle. It is also advantageous if the detection means are adapted to measuring an acoustical or optical characteristic of the substrate, and wherein the control means are programmed to determine a defect by comparison of the measured characteristic of the substrate with a predetermined characteristic of the substrate.
- the detection means and control means are adapted to quantize the amount of biofluid deposited by the nozzle, for instance by a predetermined relationship between the deposited amount of biofluid and the measured characteristic.
- the detection means comprise quantization means for determining the amount of biofluid deposited on a predetermined location of the substrate by the primary nozzle, wherein the control means are programmed to have the secondary nozzle deposit an additional amount of the same biofluid to yield a total deposited amount equal to a predetermined total amount of biofluid to be deposited on the substrate.
- the final deposited amount equals the predetermined amount of biofluid. This results in a higher quality of the final product, and less fall-out of products due to defects.
- the quantization means may for instance comprise optical sensors determining fluorescence, light absorption, lightscattering or other optical characteristics, depending on the type of biofluid to be quantized.
- the invention also relates to the use of the device according to the invention in the production of biological test arrays comprising a substrate with a plurality of bio fluids deposited thereon.
- biological test arrays produced with such a machine are less likely to contain defects and are therefore more reliable.
- the production with such a device is faster and more cost-effective, as the device is less prone to down time for maintenance or replacement of nozzles and/or print heads.
- the invention further relates to a method for producing a biological test array by depositing a plurality of bio fluids onto the substrate, using a printer device according to any of the preceding claims, comprising the process steps of positioning the print head relative to the substrate, depositing a droplet of a biofluid onto the substrate by the primary nozzle, detection of defects in the depositing by the primary nozzle, and subsequent depositing by the secondary nozzle if a defect in the deposited amount of biofluid by the first nozzle is detected.
- the invention also relates to a biological test array comprising a substrate with a plurality of bio fluids deposited thereon, obtainable by the method according to the invention.
- Biological test arrays produced with such a machine are less likely to contain defects and are therefore more reliable.
- the biofluids deposited on the substrate in production are not necessarily fluids anymore in the final product.
- the biofluid spots on the substrate may for instance be solid- or gel-spots in the final product.
- a biological test array comprises 100-1000 spots, although larger amounts are also used. Each spot typically represents up to 1 nano liter of biofluid to be deposited by a nozzle.
- the diameter of the spots is typically between 10-500 ⁇ m, preferably between 50-200 ⁇ m, and distances between spots within the array pattern are typically from 10-500 ⁇ m, preferably 75-400 ⁇ m.
- InkJet technology may be applied to achieve deposition the biofluid.
- Porous membranes are a preferred substrate.
- each type of bio fluid has at least one dedicated print head.
- at least 2 print heads are dedicated to a single type of bio fluid.
- the substrate may for instance be a porous membrane.
- the invention moreover comprises a biological test kit comprising a biological test array according to the invention.
- the kit may comprise fluorescent labels, buffer solutions and other tools for sample preparation.
- Fig. 1 shows a biological test array
- Figs. 2a and 2b show embodiments of the method according to the invention.
- Fig. 3 shows a device according to the invention.
- Fig. 4 shows another printer device according to the invention.
- Fig. 1 shows a biological test array (20) comprising spots (21) deposited on a circular membrane (22) of about 6 mm in diameter and covered with a pattern of 128 spots (21) comprising 43 different bio fluids, printed in a predefined pattern.
- the spots (21) are numbered, and each number represents a unique gene sequence or contains reference material. Note that the gene sequences occur in multiple duplicates in the array (20) on multiple mutually distant locations.
- the membrane (22) is fitted onto a supporting structure (23). As this is only an example, the number of spots may vary, and will usually much larger, depending on the number of gene sequences and the number of duplicates used.
- the membrane (22) with the supporting structure (holder) (23) is placed a cartridge (24).
- the blood sample containing the different gene sequences characteristic for the DNA of different bacteria is brought into contact with the membrane (22) comprising the array of spots (21).
- Different DNA types (gene sequences) adhere to the different printed capture spots.
- the numbers 1 to 18 represent 9 different pathogens and 9 resistances.
- the same bioselective capture material is printed in four different spots. In each of these quadrants (25), spots of the same number have different neighboring spots, preventing that less intense spots (21) are not detected because of overexposure from adjacent spots (21).
- Intensity calibration spots are printed (Rl-RlO) as well as four spots (D) in the corners of the membrane for the intensity calibration distribution over the membrane (22).
- PCR control spots (Pl, P2) are also printed to validate the proper DNA-amplification by means of PCR.
- Figs. 2a and 2b show configurations a printer head fixture plate (30) of a number of multi-nozzle print heads (31) for printing substrates (32) with different biofluids.
- Each bio fluid may for instance contain a DNA sequence such as shown in Fig. 1.
- the membranes (32) are printed with a four by four array of dots (34).
- a corresponding larger number of print heads 31 is needed.
- the print direction is shown with arrow X, the dots are arranged in rows in direction Y, perpendicular to the print direction X.
- FIGs. 2a and 2b show an arrangement where the print heads (31) filled with the same fluid are placed next to each other.
- the software controlling the print operation registers exactly where the different print heads are located in the print head fixture plate. Before starting the printing process all nozzles (33) are checked optically and acoustic fingerprints are recorded, as a reference characteristic for proper functioning.
- the actual pressure recordings are compared with the acoustic and/or optical fingerprints.
- the software controlling the overall printing operation stops that nozzle (31) and let the amount of fluid needed be deposited by the corresponding secondary nozzle (31) of the print head containing the same fluid.
- these arrangements of print heads and nozzles offer the possibility of repairing and maintaining the primary nozzles while the secondary nozzle takes over the tasks of the primary nozzle, thus enabling a higher production speed and reducing down time of the device.
- Maintenance of a nozzle (31) may for instance include purging and/or cleaning of the nozzle plate.
- the quality of the produced array of dots is improved, resulting in less defect products (with for instance missing spots or misprinted spots) and reduction of waste.
- Fig. 3 shows a printer device (40) mounted with 2 membranes (41), that are part of an elongate tray that supplies multiple substrates (41) to the assembly (42) of linear array print heads (43, 44).
- the action of the print heads (43, 44) is monitored optically and/or acoustically by detection means known in the art.
- a nozzle (45) fails the print head (43) is moved by a mechanism in the Y direction such that a new set of nozzles (46) comes into action.
- the Figure shows a print head with double the amount of nozzles needed during printing, so there is one back-up nozzle (46) for each operating nozzle (45).
- the number of rows on the substrate and the number of nozzles of the print head may be increased in order to provide a greater flexibility and a higher level of fail-proof.
- Fig. 4 shows a printer device wherein a two sets of printer heads (50, 51) are arranged according to the invention.
- the first set of printer heads (50) has printed dots on a substrate (52).
- Optical detection means (not shown), detect two defects (53) with respect to the predetermined pattern that should have been printed.
- the second set of print heads (51) corrects the omitted dots (53) by applying new dots (54), resulting in substrates (55) with the correct predetermined pattern.
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Coating Apparatus (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/306,289 US20090203544A1 (en) | 2006-07-05 | 2007-07-03 | Method and use of a printer device for producing biological test arrays |
EP07789871A EP2041582A1 (en) | 2006-07-05 | 2007-07-03 | Method and use of a printer device for producing biological test arrays |
BRPI0713960-8A BRPI0713960A2 (en) | 2006-07-05 | 2007-07-03 | Printing device and method for producing biological testing arrangements, use of printing device, biologic testing arrangement, and biological testing kit |
JP2009517580A JP2009543042A (en) | 2006-07-05 | 2007-07-03 | Method for making a biological test array and use of a printer device for making a biological test array |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06116646.8 | 2006-07-05 | ||
EP06116646 | 2006-07-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008004186A1 true WO2008004186A1 (en) | 2008-01-10 |
Family
ID=38663151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2007/052591 WO2008004186A1 (en) | 2006-07-05 | 2007-07-03 | Method and use of a printer device for producing biological test arrays |
Country Status (7)
Country | Link |
---|---|
US (1) | US20090203544A1 (en) |
EP (1) | EP2041582A1 (en) |
JP (1) | JP2009543042A (en) |
CN (1) | CN101484810A (en) |
BR (1) | BRPI0713960A2 (en) |
RU (1) | RU2009103779A (en) |
WO (1) | WO2008004186A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2942100A3 (en) * | 2014-04-25 | 2015-12-09 | Research Center Pharmaceutical Engineering GmbH | In-line method for controlling and finely adjusting the amount of printed material |
EP2838659A4 (en) * | 2012-04-18 | 2016-05-25 | Biofire Diagnostics Llc | Microspotting device |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7019303B2 (en) | 2017-03-24 | 2022-02-15 | 東芝テック株式会社 | Droplet dispenser |
GB2566113B (en) * | 2017-09-05 | 2022-12-07 | Arrayjet Ltd | Microarrayer for dispensing reagent on a substrate and a method for obtaining images of the substrate during the operation of said microarrayer |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1179368A2 (en) | 2000-07-31 | 2002-02-13 | Agilent Technologies, Inc. | Method, apparatus and computer program for producing an array of chemical compounds |
EP1245530A2 (en) * | 2001-03-26 | 2002-10-02 | Canon Kabushiki Kaisha | Process for producing probe carrier and apparatus thereof |
EP1334767A1 (en) * | 2002-01-30 | 2003-08-13 | Agilent Technologies, Inc. | Error correction in array fabrication |
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JP3174539B2 (en) * | 1997-09-08 | 2001-06-11 | キヤノン株式会社 | Recording method and recording device |
US6481820B1 (en) * | 1998-05-25 | 2002-11-19 | Konica Corporation | Ink jet printer which can carry out high speed image formation and which can avoid image failure due to a defective nozzle |
WO2002004215A1 (en) * | 2000-07-07 | 2002-01-17 | Seiko Epson Corporation | Liquid container, ink-jet recording apparatus, device and method for controlling the apparatus, liquid consumption sensing device and method |
US6682172B2 (en) * | 2001-10-31 | 2004-01-27 | Agfa-Gevaert | Method and apparatus for maintaining colour sequence when printing |
US7077334B2 (en) * | 2003-04-10 | 2006-07-18 | Massachusetts Institute Of Technology | Positive pressure drop-on-demand printing |
JP2005024278A (en) * | 2003-06-30 | 2005-01-27 | Canon Inc | Manufacturing method and manufacturing device for probe carrier |
US6893175B2 (en) * | 2003-09-30 | 2005-05-17 | Pitney Bowes Inc. | Method and system for high speed digital metering |
US20060093751A1 (en) * | 2004-11-04 | 2006-05-04 | Applied Materials, Inc. | System and methods for inkjet printing for flat panel displays |
-
2007
- 2007-07-03 US US12/306,289 patent/US20090203544A1/en not_active Abandoned
- 2007-07-03 RU RU2009103779/28A patent/RU2009103779A/en not_active Application Discontinuation
- 2007-07-03 CN CNA2007800253713A patent/CN101484810A/en active Pending
- 2007-07-03 BR BRPI0713960-8A patent/BRPI0713960A2/en not_active Application Discontinuation
- 2007-07-03 EP EP07789871A patent/EP2041582A1/en not_active Withdrawn
- 2007-07-03 JP JP2009517580A patent/JP2009543042A/en not_active Withdrawn
- 2007-07-03 WO PCT/IB2007/052591 patent/WO2008004186A1/en active Application Filing
Patent Citations (3)
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EP1179368A2 (en) | 2000-07-31 | 2002-02-13 | Agilent Technologies, Inc. | Method, apparatus and computer program for producing an array of chemical compounds |
EP1245530A2 (en) * | 2001-03-26 | 2002-10-02 | Canon Kabushiki Kaisha | Process for producing probe carrier and apparatus thereof |
EP1334767A1 (en) * | 2002-01-30 | 2003-08-13 | Agilent Technologies, Inc. | Error correction in array fabrication |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2838659A4 (en) * | 2012-04-18 | 2016-05-25 | Biofire Diagnostics Llc | Microspotting device |
EP3381562A1 (en) * | 2012-04-18 | 2018-10-03 | BioFire Diagnostics, LLC | Microspotting device |
US10471408B2 (en) | 2012-04-18 | 2019-11-12 | Biofire Diagnostics, Llc | Microspotting device |
US11207655B2 (en) | 2012-04-18 | 2021-12-28 | Biofire Diagnostics, Llc | Microspotting device |
EP2942100A3 (en) * | 2014-04-25 | 2015-12-09 | Research Center Pharmaceutical Engineering GmbH | In-line method for controlling and finely adjusting the amount of printed material |
Also Published As
Publication number | Publication date |
---|---|
CN101484810A (en) | 2009-07-15 |
JP2009543042A (en) | 2009-12-03 |
EP2041582A1 (en) | 2009-04-01 |
US20090203544A1 (en) | 2009-08-13 |
BRPI0713960A2 (en) | 2012-11-27 |
RU2009103779A (en) | 2010-08-10 |
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