WO2007132482A3 - Novel process for the preparation of pitavastatin and its pharmaceutically acceptable salts - Google Patents

Novel process for the preparation of pitavastatin and its pharmaceutically acceptable salts Download PDF

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Publication number
WO2007132482A3
WO2007132482A3 PCT/IN2007/000194 IN2007000194W WO2007132482A3 WO 2007132482 A3 WO2007132482 A3 WO 2007132482A3 IN 2007000194 W IN2007000194 W IN 2007000194W WO 2007132482 A3 WO2007132482 A3 WO 2007132482A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pharmaceutically acceptable
acceptable salts
novel process
pitavastatin
Prior art date
Application number
PCT/IN2007/000194
Other languages
French (fr)
Other versions
WO2007132482A2 (en
Inventor
Reddy Manne Satyanarayana
Reddy Maramreddy Sahadeva
Original Assignee
Reddy Manne Satyanarayana
Reddy Maramreddy Sahadeva
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddy Manne Satyanarayana, Reddy Maramreddy Sahadeva filed Critical Reddy Manne Satyanarayana
Publication of WO2007132482A2 publication Critical patent/WO2007132482A2/en
Publication of WO2007132482A3 publication Critical patent/WO2007132482A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems

Abstract

Novel Process for the preparation of Pravastatin and its pharmaceutically acceptable salts compound of formula- 1 via novel triphenyl phosphonium bromide salt compound of formula-3 or tributyl phosphonium bromide salt compound of formula-7 by employing Wittig reagents. Formula (I): Wherein M is H, Na+,K+,Mg+2,Ca+2.
PCT/IN2007/000194 2006-05-17 2007-05-16 Novel process for the preparation of pitavastatin and its pharmaceutically acceptable salts WO2007132482A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN867CH2006 2006-05-17
IN867/CHE/2006 2006-05-17

Publications (2)

Publication Number Publication Date
WO2007132482A2 WO2007132482A2 (en) 2007-11-22
WO2007132482A3 true WO2007132482A3 (en) 2008-04-10

Family

ID=38694311

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000194 WO2007132482A2 (en) 2006-05-17 2007-05-16 Novel process for the preparation of pitavastatin and its pharmaceutically acceptable salts

Country Status (1)

Country Link
WO (1) WO2007132482A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455640B2 (en) 2006-05-03 2013-06-04 Msn Laboratories Limited Process for statins and its pharmaceutically acceptable salts thereof
HUE028475T2 (en) 2006-10-09 2016-12-28 Msn Laboratories Private Ltd Novel process for the preparation of statins and their pharmaceutically acceptable salts thereof
KR101063146B1 (en) * 2008-11-10 2011-09-07 미래파인켐 주식회사 Method for preparing pitavastatin intermediate and method for preparing pitavastatin hemicalcium salt
EP2387561A4 (en) 2009-01-19 2012-07-25 Msn Lab Ltd Improved process for the preparation of highly pure (3r,5s)-7-ý2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl¨-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
KR101160152B1 (en) * 2009-02-24 2012-06-27 한미사이언스 주식회사 Novel process for preparing statin compound or its salt and intermediate used therein
EP2526099B1 (en) 2010-01-18 2016-03-30 MSN Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
WO2011089623A2 (en) 2010-01-20 2011-07-28 Cadila Healthcare Limited Process for preparing pitavastatin and pharmaceutically acceptable salts thereof
KR101134021B1 (en) * 2010-02-24 2012-04-05 주식회사 메디켐코리아 Manufacturing method of pitavastatin hemicalcium using novel intermediates
KR100995882B1 (en) * 2010-06-08 2010-11-22 에이치 엘 지노믹스(주) Process for preparing intermediate of pitavastatin or its salt
WO2011160974A2 (en) * 2010-06-21 2011-12-29 Nicox S.A. Statin derivatives
WO2012025939A1 (en) 2010-08-25 2012-03-01 Cadila Healthcare Limited Pitavastatin calcium and process for its preparation
EP2638013A4 (en) 2010-11-12 2014-03-26 Hetero Research Foundation Novel polymorphs of pitavastatin calcium
WO2012106584A2 (en) * 2011-02-04 2012-08-09 Dr. Reddy's Laboratories Ltd. Pitavastatin salts
CN102174039B (en) * 2011-03-10 2013-11-06 上海交通大学 Preparation method of high-optical-purity pitavastatin calcium key intermediate
KR101428580B1 (en) * 2011-05-06 2014-08-13 웰이앤씨 주식회사 Process for the preparation of t-butyl 2-((4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxane-4-yl)acetate
SI2751081T1 (en) * 2011-09-12 2017-05-31 Farma Grs, D.O.O. Polymorphic form of pitavastatin calcium
JP2013103884A (en) * 2011-11-10 2013-05-30 Daito Kk Industrial production method of pitavastatin calcium salt
WO2013098773A1 (en) * 2011-12-28 2013-07-04 Dr. Reddy's Laboratories Limited Crystalline forms of pitavastatin calcium
CN102898367B (en) * 2012-11-15 2014-04-30 江苏阿尔法药业有限公司 Preparation method of pitavastatin calcium crude drug midbody
WO2014203045A1 (en) 2013-06-20 2014-12-24 Lupin Limited A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate
CN103508948A (en) * 2013-10-17 2014-01-15 凯莱英医药集团（天津）股份有限公司 Method for preparing pitavastatin calcium
CN103694228B (en) * 2013-12-18 2018-08-28 北京华禧联合科技发展有限公司 A method of preparing Pitavastatin Calcium key intermediate
CN104072415A (en) * 2014-05-16 2014-10-01 南通常佑药业科技有限公司 Preparation method of pitavastatin calcium
CN110407818A (en) * 2019-07-18 2019-11-05 安庆恩聚生物医药科技有限公司 A kind of preparation method of Pitavastatin Calcium intermediate
CN111875538B (en) * 2020-08-06 2022-05-17 安徽省庆云医药股份有限公司 Synthetic method of pitavastatin tert-butyl ester
CN113651802B (en) * 2021-10-21 2022-03-29 天地恒一制药股份有限公司 One-pot preparation method of pitavastatin calcium intermediate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011898A1 (en) * 1992-05-12 1995-05-04 Nissan Chemical Industries Ltd. Condensed pyridine type mevalonolactone intermediate and process for its production
JP2005047803A (en) * 2001-05-15 2005-02-24 Ube Ind Ltd Method for producing (3r,5s)-7-substituted-3,5-dihydroxyhept-6-enoic acid
WO2005054207A1 (en) * 2003-12-04 2005-06-16 Glenmark Pharmaceuticals Limited Process for the preparation of pyrimidine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011898A1 (en) * 1992-05-12 1995-05-04 Nissan Chemical Industries Ltd. Condensed pyridine type mevalonolactone intermediate and process for its production
JP2005047803A (en) * 2001-05-15 2005-02-24 Ube Ind Ltd Method for producing (3r,5s)-7-substituted-3,5-dihydroxyhept-6-enoic acid
WO2005054207A1 (en) * 2003-12-04 2005-06-16 Glenmark Pharmaceuticals Limited Process for the preparation of pyrimidine derivatives

Also Published As

Publication number Publication date
WO2007132482A2 (en) 2007-11-22

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