WO2007129324A2 - dispositif d'injection jetable avec mÉcanisme d'auto-rÉtraction - Google Patents

dispositif d'injection jetable avec mÉcanisme d'auto-rÉtraction Download PDF

Info

Publication number
WO2007129324A2
WO2007129324A2 PCT/IL2007/000558 IL2007000558W WO2007129324A2 WO 2007129324 A2 WO2007129324 A2 WO 2007129324A2 IL 2007000558 W IL2007000558 W IL 2007000558W WO 2007129324 A2 WO2007129324 A2 WO 2007129324A2
Authority
WO
WIPO (PCT)
Prior art keywords
barrel
inner sleeve
needle
triggering
sleeve
Prior art date
Application number
PCT/IL2007/000558
Other languages
English (en)
Other versions
WO2007129324A3 (fr
WO2007129324B1 (fr
Inventor
Gil Yigal
Original Assignee
Gil Yigal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gil Yigal filed Critical Gil Yigal
Publication of WO2007129324A2 publication Critical patent/WO2007129324A2/fr
Publication of WO2007129324A3 publication Critical patent/WO2007129324A3/fr
Publication of WO2007129324B1 publication Critical patent/WO2007129324B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion

Definitions

  • the present invention relates to injecting devices and in particular to disposable automatic injecting devices for injecting a predetermined dose of medication, including auto retraction of the needle after the injection of the dose of medication is terminated.
  • All auto-injectors aim to automate the injection process to enable a user, spatially a self user, to perform injection in safety and convenience.
  • the injection process includes the following steps: a) a needle penetrating into the tissue; b) delivering the dose; and c) retracting the needle back into the device.
  • Prior art auto-injectors facilitate auto penetration and auto delivery, but are having difficulties to auto retract the needle.
  • Prior art auto-injectors fail to provide a reliable and accurate mechanism for instantly retracting the needle very close to end of the dosage delivery, such that only a minimal and repeatable residual volume of liquid is left in the injector, and prior art auto-injectors fail to provide such a mechanism that would be simple and cost effective.
  • An attempt to overcome the problem of inaccuracy and reliability in facilitating auto retraction of the needle is described in application No. WO2005115512 ('512).
  • Application '512 describes a two-part drive, incorporating a fluid-damped delay mechanism that is activated close to end of delivery, enabling the needle retraction to occur even after the plug has reached the bottom of the syringe barrel, thereby ensuring complete discharge of the syringe contents.
  • the drawback of this method is in being complicated and expansive and the anxiety of contamination by involving of liquid.
  • a common trend in prior art auto-injectors is to compromise on: a) A passive shielding of the needle upon removal of the injector from the injection site is provided by a spring biased sleeve (US Patents No. 5,137,516 and 6,932,793).
  • a needle retracting mechanism that is manually triggered by the user after the drug delivery has been completed is provided in US Patent No. 6,159,181. The user obtains indication that the drug delivery is completed by inspecting, through a window in the drug reservoir, that the syringe plug has reached the bottom of the reservoir. This indication is not definite, often inconvenient and depending on the location of the delivery site.
  • One more disadvantage refers to safety issues resulted from the fact that the user might forget to activate the needle retraction, and thus leave the needle projected with the risk of injury by a possibly contaminated needle.
  • Another disadvantage refers to the user's inconvenience as a result of applying activities and responsibilities on the user.
  • the injecting device of the present invention is an elongated device having a substantially tubular body, including a central axis.
  • the components of the injecting device of the present invention are also generally elongated with a substantially tubular structure.
  • the injecting device of the present invention is operatively directional, designed to inject liquid medication into a tissue at target injection site.
  • proximal end of the injecting device, or an elongated component thereof, as used herein refers to the end being proximal to the target injection site.
  • distal end of the injecting device, or an elongated component thereof, as used herein, refers to the end being distal from the target injection site.
  • distal refers to a direction of movement or direction of forces means a direction towards the distal end of the injecting device.
  • proximally refers to a direction of movement or direction of forces means a direction towards the proximal end of the injecting device.
  • a principal intention of the present invention is to provide disposable auto- injectors that facilitate full automation of injection process including auto retraction of the needle into the device at end of delivery without the drawbacks prior art automatic injectors.
  • the injecting device of the present invention operates a reservoir containing liquid medication and a needle providing a passageway for delivering the medication from the reservoir into the tissue during injection.
  • the medication reservoir includes: (i) a barrel, wherein the barrel is narrowed and closed at the barrel proximal end and opened at the barrel distal end; (ii) a plug, wherein the plug is slidably disposed inside the barrel; (iii) a plunger rod, wherein the proximal end of the plunger rod extends into the opening at the distal end of the barrel; and (iv) a liquid medication contained in a chamber formed inside the barrel between the proximal end of the barrel and the plug.
  • the needle is arranged to deliver the medication from the reservoir into the injection site.
  • the injecting device By releasing a safety catch and forcing the device against an injection site, the injecting device automatically manipulates the reservoir and the needle to perform needle penetration into the injection site, medication dose delivery, and needle retraction at the end of the delivery.
  • the needle is either affixed to the proximal narrowed end of the reservoir barrel or is part of a separate needle assembly, and is automatically connected to the reservoir at the beginning of injection process.
  • a disposable i ⁇ j ection device for automatically extend the needle for penetrating the tissue of a user, deliver a predetermined dose of medication stored in the medication reservoir into the tissue, and automatically retracts from the injection site, leaving substantially no residual volume of medication in the reservoir.
  • the injection device includes: a) a housing; b) an internal assembly including: an inner sleeve, a driving sleeve and a propelling spring located and acting between the inner sleeve and the driving sleeve.
  • the inner sleeve is initially disposed with free peripheral space inside a bore of the driving sleeve.
  • the propelling spring is disposed inside the free peripheral space.
  • the driving sleeve and the inner sleeve are initially interlocked, thereby restraining the propelling spring in a compressed state inside the free peripheral space; and c) a return spring with a stored potential energy significantly smaller with respect to the residual energy of the propelling spring.
  • the return spring is being compressed during an injection process, and performs automatic retraction of the medication reservoir and needle, upon termination of the injection process.
  • the return spring is substantially uncompressed when the medication reservoir is in a retracted position.
  • the driving sleeve upon unlocking the initial interlock of the inner sleeve with the driving sleeve, is being driven proximally by the propelling spring and the inner sleeve is axially disposed in a determined location with respect to the housing, at least during an injection.
  • the driving sleeve further includes at least one arm extending distally and operatively engaged with the distal end of the plunger rod.
  • the arm being part of the driving sleeve, pulls the plunger rod proximally, and with the friction between the plug and the barrel of the reservoir and the resistance of the medication, moving the medication reservoir from the retracted position to the forward position, while compressing the return spring.
  • the medication reservoir is stopped by the inner sleeve.
  • the plunger rod drives the plug proximally along the barrel of the reservoir, thereby expelling the liquid medication through the passageway in the needle.
  • the distal end of the inner sleeve includes an outer flange, which contains at least one notch on the circumference of the flange, enabling the at least one arm to pass through the outer flange towards the distal ends of the plunger rod.
  • the arm is arranged to be disposed outwardly, at least during injection.
  • the engagement is obtained by providing an inwardly projection at the distal end of the arm, wherein the inwardly projection abuts an outer face of the distal end of the plunger rod by an outwardly inclined face of the projection, and wherein the projection is disposed inwardly towards the device central axis, respective to a higher distance from the central axis of a vector of force pulling the arm being, thereby creating an outwardly moment on the arm, and thereby causing an outwardly disposition of the arm.
  • the medication reservoir is stopped by the inner sleeve, when the narrowed proximal end of the barrel of the medication reservoir encounters an inwardly peripheral extension, extending from the inner wall of the inner sleeve at the proximal end of the inner sleeve or a few millimeters distally from the proximal end of the inner sleeve.
  • the medication reservoir is stopped by the inner sleeve when a finger flange at the distal end of the medication reservoir encounters the distal end of the inner sleeve.
  • the housing includes a gripping barrel and a triggering barrel.
  • the triggering barrel is slidably adopted inside the gripping barrel through and partially projected from the proximal opened end of the triggering barrel.
  • the triggering barrel is initially in a rest position.
  • the triggering barrel is distally moved a small distance into the gripping barrel to reach a triggering position.
  • An injection is triggered when an external force is applied to operate a distal movement of the triggering barrel from the rest position to the triggering position, thereby causing the internal assembly to unlock the initial interlock of the inner sleeve with the driving sleeve.
  • the gripping barrel having an inner wall, further includes a longitudinal supports for supporting the arms of the driving sleeve. The longitudinal supports holds against the outwardly disposition of the arms, thereby preventing the arm from being deformed outwardly and maintaining the engagement of the arm with the plunger rod, along the movement of the driving sleeve.
  • the longitudinal support has a proximal end in a pre-designed location, where the longitudinal support stops supporting the arm.
  • the location is designed such that substantially all of the medication is delivered.
  • the outwardly moment on the arm causes an outwardly deformation of the arm, disengaging the arm from the plunger rod, and thus enabling the compressed return spring to force the medication reservoir back to the retracted position.
  • the inner sleeve is axially situated in a pre-determined location with respect to the housing.
  • the distal end of the triggering barrel biases the proximal side of the outer flange of the inner sleeve, forcing the outer flange against an internal abutment on the inner wall of the gripping barrel, which abuts the distal side of the outer flange of the inner sleeve.
  • each of the inclined side walls of the triggering barrel biases an adjacent side wall of a notch in the outer flange of the inner sleeve, to rotate the inner sleeve, while the outer flange of the inner sleeve is abutted by an internal abutment on the inner wall of the gripping barrel, and thereby preventing a distal movement of the inner sleeve.
  • the propelling spring which is initially restrained inside the free peripheral space created by the interlocked driving sleeve and the inner sleeve, is supported at a first end by the outer flange of the inner sleeve and supported at a second end by an inwardly peripheral abutment at the proximal end of the driving sleeve.
  • the inner sleeve and the driving sleeve contain locking elements designed to be unlocked by the limited rotation.
  • the inner sleeve includes longitudinal grooves opened proximally and ending distally with notches extending radially from the distal ends.
  • the driving sleeve further includes dowels extending inwardly from the proximal end, wherein the dowels extend closer to the central axis of the device respectively to the abutment for supporting the propelling spring. The interlock is obtained by engaging the dowels with the notches.
  • the medication reservoir is a pre-filled syringe ending proximally with a hub having an orifice, and with the needle initially coupled to the orifice of the hub.
  • the syringe is in the forward position, and is initially sealed closed at the proximal end by a needle shield covering the needle.
  • the distal end of the needle shield is abutted by the front face of the inwardly peripheral extension of the inner sleeve.
  • the needle shield is encircled by a releaser, having a substantially cylindrical body.
  • the releaser is arranged to release and remove the sealing coupling of the needle shield.
  • the releaser further includes a small sectioned arms ending with small inwardly projections, arranged to release the sealing coupling and support the needle shield during removal.
  • the release is obtained by distally pushing the releaser by an external force, thereby pushing the narrowed end of the syringe by the inwardly projections of the arms.
  • the syringe moves distally to the retracted position, while the distal end of the needle shield is being abutted by the inwardly peripheral extensions of the inner sleeve, thereby preventing the needle shield from moving distally.
  • the removal of the needle shield is obtained by the inner side of the inwardly projections abutting the distal end of the needle shield, thereby being removed together with the releaser, when the later is removed.
  • the releaser serves as a safety catch.
  • the releaser couples the inner sleeve to the triggering barrel, thereby preventing rotation of the inner sleeve with respect to the triggering barrel.
  • the safety catch is canceled when the releaser is removed.
  • the releaser includes longitudinal ribs, which are fitly inserted through notches in the opening at the proximal end of the triggering barrel, and through grooves in the inner sleeve, thereby preventing the rotation of the inner sleeve with respect to the triggering barrel.
  • the medication reservoir is a cartridge closed proximally with a piercable stopper.
  • the needle is part of a needle assembly including a cannula sharpen at both ends and a middle wall for initially holding the needle proximally to the cartridge with the distal end of the cannula adjacent to the stopper.
  • the injecting device includes a longitudinal window for inspecting the medication barrel.
  • the window includes respective openings in the gripping barrel, the triggering barrel and the inner sleeve.
  • the triggering barrel includes a safety catch preventing distal movement of the triggering barrel, thereby preventing activation of an injection.
  • the safety catch limits the rotation of the triggering barrel with respect to the gripping barrel.
  • the safety catch is operable to free the blocking by a limited rotation of the triggering barrel with respect to the gripping barrel.
  • the safety catch is a blocking element, which prevents the triggering barrel from moving with respect to the gripping barrel.
  • the safety catch is operable to free the blocking by removing of the blocking element.
  • the safety catch is a blocking element, which is engaged with the flange of the inner sleeve, thereby preventing the rotation of the inner sleeve with respect to the driving sleeve.
  • the safety catch is operable to free the blocking by removing of the blocking element.
  • the present invention includes a method for automatically inject a predetermined dose of medication into a tissue at a target injection site, using an injecting device according to the present invention.
  • the method includes distally moving the triggering barrel with respect to the gripping barrel, there releasing the interlock of the inner sleeve and the driving sleeve.
  • the present invention includes a method for removing a needle shield using a releaser including the steps of: a) forcing a releaser distally towards the injecting device, thereby disengaging the needle shield from the medication reservoir; and b) withdrawing the releaser together with the needle shield.
  • FIGs. Ia, Ib and Ic illustrate prospective views of an automatic injection device according to embodiments of the present invention, showing the device from the outside and from the inside through a section and semi section view;
  • FIG. 2 is a prospective view illustration of the main components of an automatic injection device according to embodiments of the present invention
  • FIG. 3 is a section view illustration of the automatic injection device shown in Figure 2;
  • FIG. 4 is a prospective and section views of the internal assembly of an automatic injection device according to embodiments of the present invention.
  • FIG. 5 defines by illustration cross sections A-A and B-B of an automatic injection device according to embodiments of the present invention.
  • FIG. 6a illustrates a B-B section view of an automatic injection device with the internal assembly in a locked position, according to embodiments of the present invention
  • FIG. 6b illustrates a B-B section view of the device with the internal assembly shown in
  • FIG. 7 is a perspective view illustration of an automatic injection device according to embodiments of the present invention, secured with a safety catch;
  • FIG. 8 is a perspective view illustration of the device shown in Figure 7, with the safety catch released;
  • FIG. 9 is a perspective view illustration of the device shown in Figure 7, triggered for injecting
  • FIG. 10 illustrates an A-A section view of an automatic injection device according to embodiments of the present invention, in the position shown in Figure 8;
  • FIG. 11 illustrates an A-A section view of an automatic injection device according to embodiments of the present invention, in the position shown in Figure 9;
  • FIG. 12 illustrates an A-A section view of the device shown in Figure 7, with the needle projected for tissue penetration;
  • FIG. 13 illustrates an A-A section view of the device shown in Figure 7, after the delivery of the medication
  • FIG. 14 illustrates an A-A section view of the device shown in Figure 7, with the driving sleeve disengaged from the plunger rod;
  • FIG. 15 illustrates an A-A section view of the device shown in Figure 7, after the needle retracts into the device
  • FIG. 16 illustrates an A-A section view of an automatic injection device, according to embodiments of the present invention, utilizing a pre-filled cartridge and a needle assembly, in rest position;
  • FIG. 17 illustrates an A-A section view of the device shown in Figure 16, after being triggered for injecting
  • FIG. 18 illustrates an A-A section view of the device shown in Figures 16 and 17, with the needle projected for penetrating the tissue target injection site
  • FIG. 19a is a section view illustration of another embodiment of an automatic injection device according to embodiments of the present invention, with an extractor that facilitates removal of the needle shield when utilizing pre-filled syringes;
  • FIG. 19b is a section view illustration of the device shown in Figure 19a, after forcing the extractor distally inwards the device);
  • FIG. 19c is a section view illustration of the device shown in Figures 19a and 19b, after removing of the extractor with the needle shield from the device;
  • FIG. 20 is a semi section view illustration of the device shown in Figures 19a, 19b, and 19c, in the position shown in Figure 19a but with the syringe and the needle shield hidden;
  • FIG. 21 is a prospective view illustration of the device shown in Figures 19, 20 and 21, in the position shown in Figure 19c.
  • FIG. 49 illustrates prospective views of an automatic injection device 100 according to embodiments of the present invention, showing device 100 from the outside and from the inside through a section and semi section view.
  • Injecting device 100 consists of an internal assembly 400, which is housed inside gripping barrel 50 and triggering barrel 60, and holds a standard pre-filled syringe 30.
  • FIG. 50 Reference is also made to Figures 2 and 3, which illustrate prospective and section views of the main components of automatic injection device 100 and a standard pre- filled syringe 30.
  • the standard pre-filled syringe 30 consists of: a) a syringe barrel 31 that is opened distally with an outer finger's flange 32 and narrowed to a neck ending with a hub 37 in syringe barrel 31 proximal end; b) a needle 33 is coupled to the orifice of hub 37 of syringe barrel 31 and extended proximally, initially housed with needle shield 39.
  • Needle shield 39 includes an elastomeric cap, which covers needle 33 and is sealed fitted to the outer radii of hub 37 of syringe barrel 31. Needle shield 39 may also include a rigid plastic cap which covers the elastomeric cap; c) a plug 34, slidably located inside syringe barrel 31; d) liquid medication delimited inside syringe barrel 31 between plug 34 and needle 33; and e) a plunger rod 35 abuts the back of plug 34, extends distally out of syringe barrel 31 and ends with a disk 36.
  • Gripping barrel 50 is closed at the distal end and opened at a proximal end.
  • Triggering barrel 60 is opened distally and closed with a head section 63 in the proximal end.
  • Head section 63 has a small opening 64 at the center of the head to allow the projection of needle 33.
  • FIG 4 is a prospective and section views of the internal assembly 400 of automatic injection device 100, according to embodiments of the present invention.
  • Internal assembly 400 consists of inner sleeve 410, driving sleeve 420, propelling spring 430 and return spring 440.
  • Inner sleeve 410 is initially disposed with free peripheral space within a bore of driving sleeve 420 and axially locked to driving sleeve 420 by designated locking elements 413 and 422.
  • Propelling spring 430 is slidably cooperated within the free peripheral space, between the interior bore of driving sleeve 420, and the outer radial face of inner sleeve 410.
  • Inner sleeve 410 contains an outer flange 411 at the distal end of inner sleeve 410, and inwardly peripheral extension 412 in the proximal end of inner sleeve 410.
  • the interior bore of inner sleeve 410 includes a section with wider diameter 415 ending with inner step 416.
  • Inner sleeve 410 further includes longitudinal grooves 414 opened proximally and ending distally with radial notches 413.
  • Driving sleeve 420 contains at least one gripping arm 423 elongated distally operable to deform outwardly, whereby each of gripping arms 423 is ended with an inwardly projection 424.
  • Driving sleeve 420 further contains an inner rim 421 on the proximal end of driving sleeve 420, and dowels 422 extending inwardly from inner rim 421.
  • Dowels 422 are initially interlocked with radial notches 413 to disable any axial movement between inner sleeve 410 and driving sleeve 420, while locking propelling spring 430 in a compressed position, biased between outer flange 411 of inner sleeve 410 and inner rim 421 of driving sleeve 420.
  • Figure 5 defines by illustration cross sections A-A and B-B of automatic injection device 100, according to embodiments of the present invention.
  • Figure 6a illustrates a B-B section view of automatic injection device 100 with internal assembly 400 in a locked position
  • Figure 6b which illustrates a B-B section view of automatic injection device 100 with internal assembly 400 in an unlocked position.
  • Pre-filled syringe 30 is slidably cooperated within the interior bore of inner sleeve 410 of internal assembly 400, whereby the distal end with outer finger's flange 32 extends distally from inner sleeve 410.
  • Return spring 440 is wrapped over barrel 31 of pre-filled syringe 30 with the first end of return spring 440 resting against interior step 416 of inner sleeve 410, and the other end of return spring 440 biases finger's flange 32 of syringe barrel 31.
  • Figure 7 is a perspective view illustration of automatic injection device 100 according to embodiments of the present invention, secured with a safety catch. Gripping arms 423 of driving sleeve 420 elongated distally beyond the distal end of plunger rod 35 in a way that the inwardly projections 424 at end of arms 423 overlapping disc 36 from the outer side of plunger rod 35 (back support).
  • Triggering barrel 60 is axially locked with respect to gripping barrel 50 by dowels 65, which are located on leaves 68, interlacing the radial section of "L" shaped groove 51.
  • internal assembly 400 is longitudinally fixed within injector 100 by supporting outer flange 411 of inner sleeve 410 from the outside with the ends of the stopping ribs 52 (formed longitudinally along the inner wall of gripping barrel 50), and from the inside by abutment faces 66 at the distal end of triggering barrel 60.
  • FIG 8 is a perspective view illustration of device 100 shown in Figure 7, with the safety catch released
  • Figure 9 is a perspective view illustration of the device 100, triggered for injecting.
  • triggering barrel 60 is rotated with respect to the gripping barrel 50 until dowels 65 reach the routes of the axial section of the "L" shaped grooves 51, whereby abutment faces 66 no longer abut outer flange 411 and slants 67 of triggering barrel 60 (close to abutments 66) become tangent to a side wall 417 of the notch in outer flange 411.
  • triggering barrel 60 When injector 100 is pressed against a target injection site, triggering barrel 60 is forced to slide distally towards gripping barrel 50 while dowels 65 slide along the axial section of the "L" shaped grooves 51, thus eliminating rotational movement of triggering barrel 60.
  • Inner sleeve 410 when biased by slants 67 of triggering barrel 60, is abutted by the ends of stopping ribs 52 of gripping barrel 50 for preventing distal movement of inner sleeve 410.
  • the proportional rotation of inner sleeve 410 with respect to driving sleeve 420 causes the disengagement of dowels 422 in driving sleeve 420 from notches 413 in inner sleeve 410, thereby eliminating the axial lock and enabling propelling spring 430 to propel driving sleeve 420 proximally, while inner sleeve 410 is fixed to the gripping barrel 50 by outer flange 411 being clamped between the proximal ends of stopping ribs 52 of gripping barrel 50 and the distal end of triggering barrel 60.
  • FIG. 12 illustrates an A-A section view of device 100 shown in Figure 7, with needle 33 projected for tissue penetration.
  • Driving sleeve 420 propelled by propelling spring 430, drives plunger rod 35 through the back support of the inwardly projections 424 of gripping arms 423.
  • the ends of gripping arms 423 are supported along their travel by supporting ribs 53, thereby preventing arms 423 from being opened outwardly and thus maintaining the engagement of gripping arms 423 with plunger rod 35.
  • the force for compressing return spring 440 is less then the force needed to start moving elastomeric plug 34 inside syringe barrel 31 of pre-filled syringe 30, and significantly less then the force of propelling spring 430.
  • plunger rod 35 by moving proximally, biases plug 34 to drive syringe barrel 31 and to project needle 33 out of injector 100 through opening 64, while compressing return spring 440.
  • FIG. 13 illustrates an A-A section view of device 100 shown in Figure 7, after the delivery of the medication.
  • plunger rod 35 further drives plug 34 causing plug 34 to slide inside syringe barrel 31 and to expel the liquid medication through needle 33 out of syringe 30.
  • Supporting ribs 53 of gripping barrel 50 are arranged such that when plug 34 reaches close to proximal end 38 of barrel 31, the ends of gripping arms 423 pass the ends of support ribs 53.
  • Figure 14 illustrates an A-A section view of device 100 shown in Figure 7, with driving sleeve 420 disengaged from plunger rod 35.
  • Figure 15 illustrates an A-A section view of device 100 shown in Figure 7, after needle 33 retracts into device lOO.
  • the disengagement of driving sleeve 420 from plunger rod 35 enables return spring 440 to force pre-f ⁇ lled syringe 30 distally, while retracting needle 33 back into the injector housing.
  • Figure 16 illustrates an A-A section view of an automatic injection device 200, according to embodiments of the present invention, utilizing a pre-f ⁇ lled cartridge 70 and a needle assembly 80, in rest position.
  • Figure 17 illustrates an A-A section view of device 200 shown in Figure 16, after being triggered for injecting.
  • Injecting device 200 utilizes a pre-filled cartridge 70 and a needle assembly 80 instead of syringe assembly 30, utilized by injecting device 100.
  • Cartridge 70 consist of a barrel 71 proximally ended with a neck 72, caped with a piercable stopper 73 that is tighten to cartridge 70 by cover 74.
  • Piercable stopper 73 is made, for example, from rubber.
  • Cover 74 is made, for example, from aluminum.
  • Inner sleeve 210 of injecting device 200 differs with respect to injecting device 100, by having at -the proximal end of inner sleeve 210, a tubular extension 418 ending with inner rim 419. Inwardly peripheral extension 412 of injector 100 remains in the transition to extension 418.
  • Extension 418 houses return spring 440 that acts between the proximal end of cartridge 70 and the inner rim 419 at the proximal end of inner sleeve 210 to urge cartridge 70 distally.
  • Injecting device 200 further includes a needle assembly 80 that is disposed within the interior of return spring 440 (distally and separately to cartridge 70).
  • Needle assembly 80 includes a cannula 81 sharpened at both ends, a fixed middle wall 82 and a slidable wall 83, which is frictionally mounted to cannula 81 and initially disposed proximally, supported by the inner facing shoulder 419.
  • FIG. 70 Injection activation of injecting device 200 is triggered in the same manner as described for injecting device 100, utilizing pre filled syringe 30, by forcing triggering barrel 60 inwardly, while attaching device 200 against the body tissue of the target injection site.
  • FIG. 71 Referring now to Figure 18, which illustrates an A-A section view of device 200 shown in Figures 16 and 17, with needle 81 projected for penetrating the tissue at the target injection site.
  • cartridge 70 is driven proximally by driving sleeve 420, needle assembly 80 is urged by piercable stopper 73 to partially project out of device 200 for penetrating the tissue while slidable wall 83 slides towards and into contact with fixed wall 82, and thereafter, cartridge 70 is forced towards needle assembly 80 causing the distal end of cannula 81 to penetrate piercable stopper 73 of cartridge 70, thereby providing a fluid path for delivering the medication.
  • needle 81 is retracted together with the cartridge, because the holding forces between cannula 81 and stopper 73 are higher then the holding forces between cannula 81 and the tissue at the injection site.
  • Figure 19a is a section view illustration of an automatic injection device 300, according to embodiments of the present invention, with an extractor 90 that facilitates removal of the needle shield 39 when utilizing a pre-filled syringe 30.
  • Figure 19b is a section view illustration of injecting device 300 shown in Figure 19a, after forcing extractor 90 distally inwards device 300.
  • Figure 19c is a section view illustration of injecting device 300 shown in Figures 19a and 19b, after removing of extractor 90 with needle shield 39 from injecting device 300.
  • Figure 20 is a semi section view illustration of injecting device 300 shown in Figure 19, in the position shown in Figure 19a, but with syringe 30 and needle shield 39 hidden.
  • Figure 21 is a prospective view illustration of injecting device 300 shown in Figures 19, 20 and 21, in the position shown in Figure 19c.
  • Injecting device 300 differs with respect to injecting device 100, by further containing an extractor 90 for locking injecting device 300 before injecting and for easy removal of needle shield 39. Injecting device 300 also includes means for housing and communicating with extractor 90.
  • extractor 90 has a cylindrical body with longitudinal ribs 91 along the outer radial face, and arms 92 which extend distally as continuation of ribs 91 and ended with inwardly extensions 93.
  • inner sleeve 310 of injecting device 300 is generally similar to inner sleeve 410 of injecting device 100. But inner sleeve 310 of injecting device 300 has an extension 418 at the proximal end, with a wider bore size. Inwardly peripheral extension 412 in the transition to the wider bore size is preserved as in inner sleeve 410 of injecting device 100. Extractor 90 is housed within the wider bore size of extension 418, covers needle shield 39 and abuts the narrowed end of syringe 30 by inwardly extensions 93 at the ends of arms 92.
  • extractor 90 couples inner sleeve 310 to triggering barrel 60 for preventing the rotation of inner sleeve 310, which activates the injection.
  • the coupling arranged by ribs 91 which pass through notches 69 around opening 64 in head 63 of triggering barrel 60 and through longitudinal grooves 414 and extra local grooves 418 along inner sleeve 310. The coupling is canceled after extractor 90 is removed.
  • grooves 418 For assembling device 300, grooves 418 partially split inner sleeve 310 together with inwardly peripheral extension 412.
  • syringe 30, ended with needle shield 39 is inserted into inner sleeve 310 and in this variation, is forced proximally while compressing return spring 440.
  • the two medians (half s) of inner sleeve 310 are forced and deformed outwardly to let needle shield 39 pass through inwardly peripheral extension 412 of inner sleeve 310, and to facilitate the insertion of extractor 90.
  • Inner sleeve 310 is then released and thereby eliminating the outwardly deformation, letting inwardly peripheral extension 412 to be disposed in the space between the narrowed end of syringe 30 and the distal end of needle 70.
  • Injecting devices 100, 200 and 300 repeatably deliver substantially all the pre- filled medication, which is achieved by providing a short tolerances chain, while ignoring the inaccuracy in the length of syringes 30 or cartridges 70, typically made of glass, and by substantially eliminating any freedom between participating parts, resulted from a typical syringe structure.
  • medication reservoir 31 proximal drive, during an injection process is stopped by inner sleeves 410, 310 or 210, when outer finger flange 32 at the distal end of medication reservoir 31 encounters the distal end of inner sleeves 410, 310 or 210.
  • injecting devices 100, 200 or 300 include a longitudinal window for inspecting medication barrel 31.
  • the window includes respective openings in gripping barrel 50, triggering barrel 60 and inner sleeves 410, 310 or 210.
  • triggering barrel 60 includes a safety catch preventing distal movement of triggering barrel 60, thereby preventing activation of an injection.
  • the safety catch includes dowels 65, which are located on leaves 68, interlacing the radial section of an "L" shaped groove 51.
  • the safety catch limits the rotation of triggering barrel 60 with respect to gripping barrel 50.
  • the safety catch is operable to free the blocking by a limited rotation of triggering barrel 60 with respect to gripping barrel 50.
  • the safety catch is a blocking element, which prevents triggering barrel 60 from moving with respect to gripping barrel 50.
  • the safety catch is operable to free the blocking by removing of the blocking element.
  • the safety catch is a blocking element, which is engaged with outer flange 411 at the distal end of inner sleeves 410, 310 or 210, thereby preventing the rotation of inner sleeves 410, 310 or 210, with respect to driving sleeve 420.
  • the safety catch is operable to free the blocking by removing of the blocking element.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un auto-injecteur jetable facilitant l'automatisation complète du processus d'injection, y compris l'auto-rétraction de l'aiguille dans le dispositif à la fin de l'administration sans les inconvénients associés que l'on rencontre à l'heure actuelle. L'auto-injecteur jetable comprend un barillet de seringue qui est ouvert de manière distale avec une bride pour doigt externe ; une aiguille montée dans le moyeu du barillet ; un bouchon situé de manière coulissante dans le barillet ; une médication liquide délimitée à l'intérieur du barillet entre le bouchon et l'aiguille ; et une tige de piston plongeur qui bute contre l'arrière du bouchon. Le dispositif injecteur utilise un réservoir contenant une médication liquide et une aiguille pour administrer la médication, qui en relâchant un loquet de sécurité et en forçant le dispositif contre le regard d'injection, peut automatiquement manipuler le réservoir et l'aiguille pour assurer la pénétration de l'aiguille dans le regard d'injection, l'administration de médicament, et la rétraction de l'aiguille à la fin de l'administration.
PCT/IL2007/000558 2006-05-09 2007-05-09 dispositif d'injection jetable avec mÉcanisme d'auto-rÉtraction WO2007129324A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79848206P 2006-05-09 2006-05-09
US60/798,482 2006-05-09

Publications (3)

Publication Number Publication Date
WO2007129324A2 true WO2007129324A2 (fr) 2007-11-15
WO2007129324A3 WO2007129324A3 (fr) 2008-02-21
WO2007129324B1 WO2007129324B1 (fr) 2008-04-10

Family

ID=38668174

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/000558 WO2007129324A2 (fr) 2006-05-09 2007-05-09 dispositif d'injection jetable avec mÉcanisme d'auto-rÉtraction

Country Status (1)

Country Link
WO (1) WO2007129324A2 (fr)

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009062508A1 (fr) * 2007-11-12 2009-05-22 Bang & Olufsen Medicom A/S Injecteur automatique avec tige de libération rotative
WO2009081133A1 (fr) * 2007-12-20 2009-07-02 Ucb Pharma S.A. Auto-injecteur à élément souple limitant le mouvement d'un capuchon d'aiguille et formant une surface barrière servant à obstruer la sortie du cylindre de la seringue
WO2010136078A1 (fr) * 2009-05-29 2010-12-02 Tecpharma Licensing Ag Dispositif d'injection, notamment auto-injecteur comprenant une protection contre la piqûre involontaire et/ou une sécurité contre la surcharge, pour un réservoir à produit
JP2012502761A (ja) * 2008-09-18 2012-02-02 ベクトン・ディキンソン・アンド・カンパニー 回転可能な本体部を有する医用注射器
WO2012110040A1 (fr) * 2011-02-15 2012-08-23 Injector Aps Injecteur jetable pour injecter un liquide dans un patient
WO2013034986A3 (fr) * 2011-09-09 2013-07-18 Merck Patent Gmbh Auto-injecteur pour injection d'épinéphrine
EP2731645A1 (fr) 2011-07-15 2014-05-21 Antares Pharma, Inc. Dispositif d'injection avec ensemble-vérin à came
CN104105516A (zh) * 2011-12-21 2014-10-15 赛诺菲-安万特德国有限公司 具有与外柱塞脱离以使针筒托架缩回的内柱塞的自动注射器
CN104136057A (zh) * 2011-12-21 2014-11-05 赛诺菲-安万特德国有限公司 自动注射器
WO2014198799A1 (fr) * 2013-06-11 2014-12-18 Cilag Gmbh International Dispositif d'injection
US8968236B2 (en) 2005-04-06 2015-03-03 Cilag Gmbh International Injection device
US9028451B2 (en) 2006-06-01 2015-05-12 Cilag Gmbh International Injection device
US9028453B2 (en) 2008-06-19 2015-05-12 Cilag Gmbh International Reusable auto-injector
US9072833B2 (en) 2006-06-01 2015-07-07 Cilag Gmbh International Injection device
US20150272778A1 (en) * 2011-10-07 2015-10-01 Sanofi-Aventis Deutschland Gmbh Apparatus for intraocular injection
US9358346B2 (en) 2005-08-30 2016-06-07 Cilag Gmbh International Needle assembly for a prefilled syringe system
US9649441B2 (en) 2005-04-06 2017-05-16 Cilag Gmbh International Injection device (bayonet cap removal)
US9675758B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9675757B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9682194B2 (en) 2008-06-19 2017-06-20 Cilag Gmbh International Re-useable auto-injector with filling means
US9731080B2 (en) 2005-04-06 2017-08-15 Cilag Gmbh International Injection device
US9757520B2 (en) 2006-06-01 2017-09-12 Cilag Gmbh International Injection device
US9770558B2 (en) 2005-09-27 2017-09-26 Cilag Gmbh International Auto-injection device with needle protecting cap having outer and inner sleeves
US9895493B2 (en) 2004-05-28 2018-02-20 Cilag Gmbh International Injection device
CN110090337A (zh) * 2018-01-31 2019-08-06 拜耳医药保健有限公司 针筒与注射器接合的系统和方法
USRE47903E1 (en) 2010-12-21 2020-03-17 Sanofi-Aventis Deutschland Gmbh Auto-injector
US10709849B2 (en) 2013-06-11 2020-07-14 Cilag Gmbh International Guide for an injection device
US10799646B2 (en) 2013-06-11 2020-10-13 Cilag Gmbh International Injection device
USRE48593E1 (en) 2010-12-21 2021-06-15 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11123492B2 (en) 2013-06-11 2021-09-21 Cilag Gmbh International Injection device
CN113730703A (zh) * 2012-10-17 2021-12-03 椭元医疗技术有限公司 自动药物输送装置
CN113966240A (zh) * 2019-06-05 2022-01-21 里珍纳龙药品有限公司 用于精确剂量递送的装置及方法
CN114423478A (zh) * 2019-09-17 2022-04-29 碧迪股份有限公司 被动式安全装置、包括该安全装置的注射装置和用来制造所述注射装置的方法
US11400217B2 (en) 2010-12-21 2022-08-02 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11484653B1 (en) 2010-02-18 2022-11-01 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11504475B2 (en) 2010-06-28 2022-11-22 Sanofi-Aventis Deutschland Gmbh Auto-injector
WO2024032688A1 (fr) * 2022-08-10 2024-02-15 泰尔茂医疗产品(杭州)有限公司 Appareil d'administration de médicament à appareil de protection automatique
US12042636B2 (en) 2015-06-03 2024-07-23 Sanofi-Aventis Deutschland Gmbh Syringe support and autoinjector

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2461084B (en) 2008-06-19 2012-09-26 Cilag Gmbh Int Fluid transfer assembly

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2770404A1 (fr) * 1997-11-05 1999-05-07 Sedat Injecteur automatique a retraction d'aiguille en fin d'injection
GB2424838A (en) * 2005-04-06 2006-10-11 Cilag Ag Int An injection device with interchangable drive rod or coupling
WO2007002053A2 (fr) * 2005-06-21 2007-01-04 Eli Lilly And Company Dispositif d'administration de medicament muni d'une aiguille a insertion d'aiguille a declenchement automatique et a injection de medicament a commande manuelle

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2770404A1 (fr) * 1997-11-05 1999-05-07 Sedat Injecteur automatique a retraction d'aiguille en fin d'injection
GB2424838A (en) * 2005-04-06 2006-10-11 Cilag Ag Int An injection device with interchangable drive rod or coupling
WO2007002053A2 (fr) * 2005-06-21 2007-01-04 Eli Lilly And Company Dispositif d'administration de medicament muni d'une aiguille a insertion d'aiguille a declenchement automatique et a injection de medicament a commande manuelle

Cited By (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9895493B2 (en) 2004-05-28 2018-02-20 Cilag Gmbh International Injection device
US9675758B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9675757B2 (en) 2004-05-28 2017-06-13 Cilag Gmbh International Injection device
US9731080B2 (en) 2005-04-06 2017-08-15 Cilag Gmbh International Injection device
US9649441B2 (en) 2005-04-06 2017-05-16 Cilag Gmbh International Injection device (bayonet cap removal)
US8968236B2 (en) 2005-04-06 2015-03-03 Cilag Gmbh International Injection device
US9358346B2 (en) 2005-08-30 2016-06-07 Cilag Gmbh International Needle assembly for a prefilled syringe system
US9770558B2 (en) 2005-09-27 2017-09-26 Cilag Gmbh International Auto-injection device with needle protecting cap having outer and inner sleeves
US9072833B2 (en) 2006-06-01 2015-07-07 Cilag Gmbh International Injection device
US9757520B2 (en) 2006-06-01 2017-09-12 Cilag Gmbh International Injection device
US9028451B2 (en) 2006-06-01 2015-05-12 Cilag Gmbh International Injection device
US8956331B2 (en) 2007-11-12 2015-02-17 Bang & Olufsen Medicom A/S Auto injector with a rotatable release shaft
WO2009062508A1 (fr) * 2007-11-12 2009-05-22 Bang & Olufsen Medicom A/S Injecteur automatique avec tige de libération rotative
US8409141B2 (en) 2007-11-12 2013-04-02 Bang & Olufsen Medicom A/S Auto injector with automatic needle retraction
US8876779B2 (en) 2007-11-12 2014-11-04 Bang & Olufsen Medicom A/S Auto injector with changing anchor locations for a mechanical driver
WO2009081133A1 (fr) * 2007-12-20 2009-07-02 Ucb Pharma S.A. Auto-injecteur à élément souple limitant le mouvement d'un capuchon d'aiguille et formant une surface barrière servant à obstruer la sortie du cylindre de la seringue
US9028453B2 (en) 2008-06-19 2015-05-12 Cilag Gmbh International Reusable auto-injector
US9682194B2 (en) 2008-06-19 2017-06-20 Cilag Gmbh International Re-useable auto-injector with filling means
JP2012502761A (ja) * 2008-09-18 2012-02-02 ベクトン・ディキンソン・アンド・カンパニー 回転可能な本体部を有する医用注射器
US8945053B2 (en) 2009-05-29 2015-02-03 Tecpharma Licensing Ag Injection device with pricking protection and/or overload protection for a product container
US10485933B2 (en) 2009-05-29 2019-11-26 Tecpharma Licensing Ag Injection device with pricking protection and/or overload protection for a product container
US9962496B2 (en) 2009-05-29 2018-05-08 Tecpharma Licensing Ag Injection device with pricking protection and/or overload protection for a product container
EP2954914A1 (fr) * 2009-05-29 2015-12-16 TecPharma Licensing AG Dispositif d'injection, notamment auto-injecteur comprenant une protection contre la piqûre involontaire et/ou une sécurité contre la surcharge, pour un réservoir à produit
WO2010136078A1 (fr) * 2009-05-29 2010-12-02 Tecpharma Licensing Ag Dispositif d'injection, notamment auto-injecteur comprenant une protection contre la piqûre involontaire et/ou une sécurité contre la surcharge, pour un réservoir à produit
US11484653B1 (en) 2010-02-18 2022-11-01 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11730888B2 (en) 2010-02-18 2023-08-22 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11504475B2 (en) 2010-06-28 2022-11-22 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11813436B2 (en) 2010-06-28 2023-11-14 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11612691B2 (en) 2010-12-21 2023-03-28 Sanofi-Aventis Deutschland Gmbh Auto-injector
USRE47903E1 (en) 2010-12-21 2020-03-17 Sanofi-Aventis Deutschland Gmbh Auto-injector
USRE48593E1 (en) 2010-12-21 2021-06-15 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11400217B2 (en) 2010-12-21 2022-08-02 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11458252B2 (en) 2010-12-21 2022-10-04 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11471601B1 (en) 2010-12-21 2022-10-18 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11607495B1 (en) 2010-12-21 2023-03-21 Sanofi-Aventis Deutschland Gmbh Auto-injector
US11833331B2 (en) 2010-12-21 2023-12-05 Sanofi-Aventis Deutschland Gmbh Auto-injector
WO2012110040A1 (fr) * 2011-02-15 2012-08-23 Injector Aps Injecteur jetable pour injecter un liquide dans un patient
EP2731645A1 (fr) 2011-07-15 2014-05-21 Antares Pharma, Inc. Dispositif d'injection avec ensemble-vérin à came
US9764091B2 (en) 2011-09-09 2017-09-19 Merck Patent Gmbh Auto-injector for epinephrine injection
CN103945880A (zh) * 2011-09-09 2014-07-23 默克专利股份公司 具有单独针插入的自动注射器
US9775948B2 (en) 2011-09-09 2017-10-03 Merck Patent Gmbh Auto injector with separate needle injection
EP3412323A1 (fr) * 2011-09-09 2018-12-12 Merck Patent GmbH Auto-injecteur pour injection d'épinéphrine
US10357608B2 (en) 2011-09-09 2019-07-23 Merck Patent Gmbh Re-loadable auto injector
WO2013034986A3 (fr) * 2011-09-09 2013-07-18 Merck Patent Gmbh Auto-injecteur pour injection d'épinéphrine
AU2012306064B2 (en) * 2011-09-09 2017-02-23 Merck Patent Gmbh An auto-injector for epinephrine injection
WO2013034984A3 (fr) * 2011-09-09 2013-07-25 Merck Patent Gmbh Auto-injecteur à injection par aiguille séparée
CN106075662B (zh) * 2011-09-09 2020-01-07 默克专利股份公司 具有单独针插入的自动注射器
CN106075662A (zh) * 2011-09-09 2016-11-09 默克专利股份公司 具有单独针插入的自动注射器
WO2013034985A3 (fr) * 2011-09-09 2013-12-27 Merck Patent Gmbh Auto-injecteur rechargeable
CN103764206A (zh) * 2011-09-09 2014-04-30 默克专利股份公司 用于肾上腺素注射的自动注射器
US10716899B2 (en) 2011-09-09 2020-07-21 Merck Patent Gmbh Auto injector with separate needle injection
US10765809B2 (en) 2011-09-09 2020-09-08 Merck Patent Gmbh Auto-injector for epinephrine injection
CN103945879A (zh) * 2011-09-09 2014-07-23 默克专利股份公司 可再加载的自动注射器
US9186459B2 (en) 2011-09-09 2015-11-17 Merck Patent Gmbh Auto-injector for epinephrine injection
US20150272778A1 (en) * 2011-10-07 2015-10-01 Sanofi-Aventis Deutschland Gmbh Apparatus for intraocular injection
US10653851B2 (en) 2011-12-21 2020-05-19 Sanofi-Aventis Deutschland Gmbh Autoinjector with an inner plunger which disengages the outer plunger to retract the syringe carrier
CN104136057A (zh) * 2011-12-21 2014-11-05 赛诺菲-安万特德国有限公司 自动注射器
US9827381B2 (en) 2011-12-21 2017-11-28 Sanofi-Aventis Deutschland Gmbh Autoinjector with an inner plunger which disengages the outer plunger to retract the syringe carrier
CN104105516A (zh) * 2011-12-21 2014-10-15 赛诺菲-安万特德国有限公司 具有与外柱塞脱离以使针筒托架缩回的内柱塞的自动注射器
CN113730703A (zh) * 2012-10-17 2021-12-03 椭元医疗技术有限公司 自动药物输送装置
US11173255B2 (en) 2013-06-11 2021-11-16 Cilag Gmbh International Injection device
WO2014198799A1 (fr) * 2013-06-11 2014-12-18 Cilag Gmbh International Dispositif d'injection
US10709849B2 (en) 2013-06-11 2020-07-14 Cilag Gmbh International Guide for an injection device
US10799646B2 (en) 2013-06-11 2020-10-13 Cilag Gmbh International Injection device
US11123492B2 (en) 2013-06-11 2021-09-21 Cilag Gmbh International Injection device
EA033787B1 (ru) * 2013-06-11 2019-11-26 Cilag Gmbh Int Инъекционное устройство
US12042636B2 (en) 2015-06-03 2024-07-23 Sanofi-Aventis Deutschland Gmbh Syringe support and autoinjector
CN110090337A (zh) * 2018-01-31 2019-08-06 拜耳医药保健有限公司 针筒与注射器接合的系统和方法
CN113966240A (zh) * 2019-06-05 2022-01-21 里珍纳龙药品有限公司 用于精确剂量递送的装置及方法
CN114423478A (zh) * 2019-09-17 2022-04-29 碧迪股份有限公司 被动式安全装置、包括该安全装置的注射装置和用来制造所述注射装置的方法
CN114423478B (zh) * 2019-09-17 2023-12-08 碧迪股份有限公司 被动式安全装置、包括该安全装置的注射装置和用来制造所述注射装置的方法
WO2024032688A1 (fr) * 2022-08-10 2024-02-15 泰尔茂医疗产品(杭州)有限公司 Appareil d'administration de médicament à appareil de protection automatique

Also Published As

Publication number Publication date
WO2007129324A3 (fr) 2008-02-21
WO2007129324B1 (fr) 2008-04-10

Similar Documents

Publication Publication Date Title
WO2007129324A2 (fr) dispositif d'injection jetable avec mÉcanisme d'auto-rÉtraction
US5709662A (en) Cartridge for an injection device
US5478316A (en) Automatic self-injection device
US8945049B2 (en) Auto-injector with active agent container latching
US5843036A (en) Non-dosing cartridge for an injection device
US7785292B2 (en) Injection device
EP1443992B1 (fr) Cartouche de seringue compressible
US9272098B2 (en) Auto-injector
JP5993868B2 (ja) 自動注射器用のバックエンドデバイス及び自動注射器
EP1379300B1 (fr) Systeme de protection de securite pour seringues preremplies
US11389590B2 (en) Administration assembly for a medicament delivery device
US7300416B2 (en) Pre-filled retractable needle injection ampoules
EP1496964A1 (fr) Systeme d'ecran de securite pour seringues
US11992661B2 (en) Injection device fill volume management
US20220387714A1 (en) Emergency automatic injection device
MXPA97006452A (es) Un cartucho no-dosificante para un dispositivo para inyeccion

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07736298

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07736298

Country of ref document: EP

Kind code of ref document: A2