WO2007127449A1 - Process for the preparation of cinacalcet base - Google Patents
Process for the preparation of cinacalcet base Download PDFInfo
- Publication number
- WO2007127449A1 WO2007127449A1 PCT/US2007/010370 US2007010370W WO2007127449A1 WO 2007127449 A1 WO2007127449 A1 WO 2007127449A1 US 2007010370 W US2007010370 W US 2007010370W WO 2007127449 A1 WO2007127449 A1 WO 2007127449A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cinacalcet
- base
- formula
- catalyst
- unsaturated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0702872-5A BRPI0702872A2 (en) | 2006-04-27 | 2007-04-27 | processes for preparing cinacalcide and a pharmaceutically acceptable salt thereof |
EP07794409A EP1928817A1 (en) | 2006-04-27 | 2007-04-27 | Process for the preparation of cinacalcet base |
JP2009507846A JP2009535350A (en) | 2006-04-27 | 2007-04-27 | Preparation of cinacalcet base |
MX2008000140A MX2008000140A (en) | 2006-04-27 | 2007-04-27 | Process for the preparation of cinacalcet base. |
CA002649245A CA2649245A1 (en) | 2006-04-27 | 2007-04-27 | Process for the preparation of cinacalcet base |
IL194718A IL194718A0 (en) | 2006-04-27 | 2008-10-22 | Process for the preparation of cinacalcet base |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79631706P | 2006-04-27 | 2006-04-27 | |
US60/796,317 | 2006-04-27 | ||
US79944306P | 2006-05-10 | 2006-05-10 | |
US60/799,443 | 2006-05-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007127449A1 true WO2007127449A1 (en) | 2007-11-08 |
Family
ID=38523526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/010370 WO2007127449A1 (en) | 2006-04-27 | 2007-04-27 | Process for the preparation of cinacalcet base |
Country Status (10)
Country | Link |
---|---|
US (1) | US7393967B2 (en) |
EP (1) | EP1928817A1 (en) |
JP (1) | JP2009535350A (en) |
KR (1) | KR20080011320A (en) |
BR (1) | BRPI0702872A2 (en) |
CA (1) | CA2649245A1 (en) |
IL (1) | IL194718A0 (en) |
MX (1) | MX2008000140A (en) |
TW (1) | TW200811082A (en) |
WO (1) | WO2007127449A1 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2022777A3 (en) * | 2007-06-22 | 2009-06-17 | Dipharma Francis S.r.l. | A process for the preparation of cinacalcet |
WO2010015935A2 (en) * | 2008-08-06 | 2010-02-11 | Actavis Group Ptc Ehf | Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride |
EP2170805A2 (en) | 2007-06-21 | 2010-04-07 | Amgen Inc. | Methods of synthesizing cinacalcet and salts thereof |
WO2010067204A1 (en) | 2008-12-08 | 2010-06-17 | Actavis Group Ptc Ehf | Highly pure cinacalcet or a pharmaceutically acceptable salt thereof |
WO2010094674A3 (en) * | 2009-02-19 | 2010-10-21 | Zach System S.P.A. | Process for preparing cinacalcet hydrochloride |
ITMI20091328A1 (en) * | 2009-07-27 | 2011-01-28 | Dipharma Francis Srl | PROCEDURE FOR THE PREPARATION OF CINACALCET |
WO2011029833A1 (en) * | 2009-09-10 | 2011-03-17 | Zach System S.P.A. | Process for preparing cinacalcet |
WO2011050499A1 (en) * | 2009-11-02 | 2011-05-05 | 上海威智医药科技有限公司 | Methods of sythesizing cinacalcet hydrochloride |
US20110172455A1 (en) * | 2008-07-08 | 2011-07-14 | Ind-Swift Laboratories Limited | Process for preparing cinacalcet and pharmaceutically acceptable salts thereof |
CN102159533A (en) * | 2008-10-28 | 2011-08-17 | Zach系统股份公司 | Process for preparing cinacalcet |
CZ303627B6 (en) * | 2011-11-25 | 2013-01-16 | Zentiva, K.S. | Process for preparing cinacalcet |
US8415501B2 (en) | 2006-03-23 | 2013-04-09 | Amgen, Inc. | Methods and compositions for making and using polymorphs of cinacalcet |
US9290439B2 (en) | 2012-09-07 | 2016-03-22 | Produits Chimiques Auxiliaires Et De Synthese | Process for preparing cinacalcet and pharmaceutically acceptable salts thereof |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010128388A2 (en) | 2009-05-08 | 2010-11-11 | Aurobindo Pharma Limited | An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet |
EP2477959A1 (en) | 2009-09-16 | 2012-07-25 | Ranbaxy Laboratories Limited | Processes for the preparation of cinacalcet |
US8722732B2 (en) | 2009-09-29 | 2014-05-13 | Nektar Therapeutics | Oligomer-calcimimetic conjugates and related compounds |
CN102573921B (en) | 2009-09-29 | 2015-11-25 | 尼克塔治疗公司 | Oligomer-calcimimetic conjugates and related compound |
CN113121388B (en) * | 2021-03-29 | 2021-11-12 | 西华大学 | Cinacalcet intermediate and synthetic method of cinacalcet hydrochloride |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6211244B1 (en) * | 1994-10-21 | 2001-04-03 | Nps Pharmaceuticals, Inc. | Calcium receptor-active compounds |
WO2006125026A2 (en) * | 2005-05-16 | 2006-11-23 | Teva Pharmaceutical Industries, Ltd. | Process for preparing cinacalcet hydrochloride |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4966988A (en) * | 1989-02-17 | 1990-10-30 | Chevron Research Company | Process for preparing acetonitrile 3-trifluoromethyl benzene |
US6031003A (en) * | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US6313146B1 (en) * | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US6011068A (en) * | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5648541A (en) * | 1995-09-28 | 1997-07-15 | Nps Pharmaceuticals, Inc. | Chiral reductions of imines leading to the syntheses of optically active amines |
SG146608A1 (en) * | 2003-09-12 | 2008-10-30 | Amgen Inc Dw Us | Rapid dissolution formulation of a calcium receptor-active compound |
US20050234261A1 (en) * | 2004-04-14 | 2005-10-20 | Honeywell International Inc. | Process for preparing cinnamic acids and alkyl esters thereof |
BRPI0609524A2 (en) * | 2005-03-17 | 2011-10-18 | Amgen Inc | use of a therapeutically effective amount of a calcimimetic compound |
-
2007
- 2007-04-27 BR BRPI0702872-5A patent/BRPI0702872A2/en not_active IP Right Cessation
- 2007-04-27 MX MX2008000140A patent/MX2008000140A/en unknown
- 2007-04-27 TW TW096115091A patent/TW200811082A/en unknown
- 2007-04-27 US US11/796,395 patent/US7393967B2/en not_active Expired - Fee Related
- 2007-04-27 KR KR1020077028890A patent/KR20080011320A/en not_active Application Discontinuation
- 2007-04-27 WO PCT/US2007/010370 patent/WO2007127449A1/en active Application Filing
- 2007-04-27 JP JP2009507846A patent/JP2009535350A/en active Pending
- 2007-04-27 EP EP07794409A patent/EP1928817A1/en not_active Withdrawn
- 2007-04-27 CA CA002649245A patent/CA2649245A1/en not_active Abandoned
-
2008
- 2008-10-22 IL IL194718A patent/IL194718A0/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6211244B1 (en) * | 1994-10-21 | 2001-04-03 | Nps Pharmaceuticals, Inc. | Calcium receptor-active compounds |
WO2006125026A2 (en) * | 2005-05-16 | 2006-11-23 | Teva Pharmaceutical Industries, Ltd. | Process for preparing cinacalcet hydrochloride |
Non-Patent Citations (2)
Title |
---|
DEVASHER R B ET AL: "Aqueous-Phase, Palladium-catalyzed cross-coupling of aryl bromides under mild conditions, using water-soluble, sterically demanding alkylphosphines", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 69, 2004, pages 7919 - 7927, XP002387110, ISSN: 0022-3263 * |
SORBERA L A ET AL: "Cinacalcet hydrochloride", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 27, no. 9, 2002, pages 831 - 836, XP002403819, ISSN: 0377-8282 * |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8415501B2 (en) | 2006-03-23 | 2013-04-09 | Amgen, Inc. | Methods and compositions for making and using polymorphs of cinacalcet |
EP2170805A2 (en) | 2007-06-21 | 2010-04-07 | Amgen Inc. | Methods of synthesizing cinacalcet and salts thereof |
EP2170805B1 (en) * | 2007-06-21 | 2016-03-16 | Amgen Inc. | Methods of synthesizing cinacalcet and salts thereof |
AU2008269181B2 (en) * | 2007-06-21 | 2014-04-17 | Amgen Inc. | Methods of synthesizing cinacalcet and salts thereof |
EP2022777A3 (en) * | 2007-06-22 | 2009-06-17 | Dipharma Francis S.r.l. | A process for the preparation of cinacalcet |
US20110172455A1 (en) * | 2008-07-08 | 2011-07-14 | Ind-Swift Laboratories Limited | Process for preparing cinacalcet and pharmaceutically acceptable salts thereof |
WO2010015935A2 (en) * | 2008-08-06 | 2010-02-11 | Actavis Group Ptc Ehf | Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride |
WO2010015935A3 (en) * | 2008-08-06 | 2010-04-15 | Actavis Group Ptc Ehf | Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride |
US20110178326A1 (en) * | 2008-08-06 | 2011-07-21 | Actavis Group Ptc Ehf | Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride |
CN102159533A (en) * | 2008-10-28 | 2011-08-17 | Zach系统股份公司 | Process for preparing cinacalcet |
WO2010067204A1 (en) | 2008-12-08 | 2010-06-17 | Actavis Group Ptc Ehf | Highly pure cinacalcet or a pharmaceutically acceptable salt thereof |
AU2010215520B2 (en) * | 2009-02-19 | 2016-07-21 | F.I.S. - Fabbrica Italiana Sintetici S.P.A. | Process for preparing Cinacalcet hydrochloride |
CN102307845B (en) * | 2009-02-19 | 2015-04-15 | Zach系统股份公司 | Process for preparing cinacalcet hydrochloride |
CN102307845A (en) * | 2009-02-19 | 2012-01-04 | Zach系统股份公司 | Process for preparing cinacalcet hydrochloride |
US9522869B2 (en) | 2009-02-19 | 2016-12-20 | Zach System S.P.A. | Process for preparing Cinacalcet hydrochloride |
WO2010094674A3 (en) * | 2009-02-19 | 2010-10-21 | Zach System S.P.A. | Process for preparing cinacalcet hydrochloride |
ITMI20091328A1 (en) * | 2009-07-27 | 2011-01-28 | Dipharma Francis Srl | PROCEDURE FOR THE PREPARATION OF CINACALCET |
JP2013504535A (en) * | 2009-09-10 | 2013-02-07 | ザック システム エス.ピー.エー. | Method for producing cinacalcet |
WO2011029833A1 (en) * | 2009-09-10 | 2011-03-17 | Zach System S.P.A. | Process for preparing cinacalcet |
US8637708B2 (en) | 2009-09-10 | 2014-01-28 | Zach System S.P.A. | Process for preparing cinacalcet |
AU2010294283B2 (en) * | 2009-09-10 | 2016-09-29 | F.I.S. - Fabbrica Italiana Sintetici S.P.A. | Process for preparing Cinacalcet |
WO2011050499A1 (en) * | 2009-11-02 | 2011-05-05 | 上海威智医药科技有限公司 | Methods of sythesizing cinacalcet hydrochloride |
CN102119137A (en) * | 2009-11-02 | 2011-07-06 | 上海威智医药科技有限公司 | Methods of sythesizing cinacalcet hydrochloride |
CZ303627B6 (en) * | 2011-11-25 | 2013-01-16 | Zentiva, K.S. | Process for preparing cinacalcet |
US9290439B2 (en) | 2012-09-07 | 2016-03-22 | Produits Chimiques Auxiliaires Et De Synthese | Process for preparing cinacalcet and pharmaceutically acceptable salts thereof |
US9598350B2 (en) | 2012-09-07 | 2017-03-21 | Produits Chimiques Auxiliaries Et De Synthese | Process for preparing cinacalcet and pharmaceutically acceptable salts thereof |
Also Published As
Publication number | Publication date |
---|---|
BRPI0702872A2 (en) | 2011-03-15 |
EP1928817A1 (en) | 2008-06-11 |
TW200811082A (en) | 2008-03-01 |
CA2649245A1 (en) | 2007-11-08 |
US20070260091A1 (en) | 2007-11-08 |
MX2008000140A (en) | 2009-02-23 |
US7393967B2 (en) | 2008-07-01 |
IL194718A0 (en) | 2009-08-03 |
JP2009535350A (en) | 2009-10-01 |
KR20080011320A (en) | 2008-02-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7393967B2 (en) | Process for the preparation of cinacalcet base | |
EP1881954B1 (en) | Process for preparing cinacalcet hydrochloride | |
EP1915335B1 (en) | Process for the preparation of cinacalcet base | |
JP2009539823A (en) | Process for preparing useful intermediate compounds for the preparation of cinacalcet | |
AU2010215520B2 (en) | Process for preparing Cinacalcet hydrochloride | |
EP2358659B1 (en) | Process for preparing cinacalcet | |
JP2008063335A (en) | Method for producing 1,2-diol from carbonyl compound | |
AU2010294283A1 (en) | Process for preparing Cinacalcet | |
CN112321451B (en) | Method for preparing cinacalcet hydrochloride drug intermediate | |
JP5531084B2 (en) | Novel method for the synthesis of ivabradine and its addition salts with pharmaceutically acceptable acids | |
WO2012051737A1 (en) | Preparation method of cinacalcet and pharmaceutical salts thereof | |
WO2012007954A1 (en) | Process for cinacalcet hydrochloride | |
CN111393309A (en) | Preparation method of (S) -1,2,3, 4-tetrahydro-5-methoxy-N-propyl-2-naphthylamine hydrochloride | |
CZ2011770A3 (en) | Process for preparing cinacalcet | |
WO2015132519A1 (en) | Method for preparing derivatives of 11-aminoundecanoic acid and 12-aminododecanoic acid |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 1020077028890 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007794409 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/A/2008/000140 Country of ref document: MX |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07794409 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2649245 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 8817/DELNP/2008 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 194718 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2009507846 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: PI0702872 Country of ref document: BR Kind code of ref document: A2 Effective date: 20071219 |