WO2007127445A2 - Process for the preparation of cinacalcet base - Google Patents
Process for the preparation of cinacalcet base Download PDFInfo
- Publication number
- WO2007127445A2 WO2007127445A2 PCT/US2007/010364 US2007010364W WO2007127445A2 WO 2007127445 A2 WO2007127445 A2 WO 2007127445A2 US 2007010364 W US2007010364 W US 2007010364W WO 2007127445 A2 WO2007127445 A2 WO 2007127445A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- trifluoromethyl
- phenyl
- compound
- preparing
- cinacalcet
- Prior art date
Links
- 0 Cc1cc(CCC(*)=O)ccc1 Chemical compound Cc1cc(CCC(*)=O)ccc1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2008013684A MX2008013684A (en) | 2006-04-27 | 2007-04-27 | Process for the preparation of cinacalcet base. |
EP07756140A EP1915335B1 (en) | 2006-04-27 | 2007-04-27 | Process for the preparation of cinacalcet base |
JP2009507844A JP5027214B2 (en) | 2006-04-27 | 2007-04-27 | Preparation of cinacalcet base |
CA002649616A CA2649616A1 (en) | 2006-04-27 | 2007-04-27 | Process for the preparation of cinacalcet base |
AT07756140T ATE447546T1 (en) | 2006-04-27 | 2007-04-27 | METHOD FOR PRODUCING A CINACALCETBASE |
DE602007003067T DE602007003067D1 (en) | 2006-04-27 | 2007-04-27 | METHOD FOR PRODUCING A CINACALCETBASE |
IL194719A IL194719A0 (en) | 2006-04-27 | 2008-10-22 | Process for the preparation of cinacalcet base |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79631806P | 2006-04-27 | 2006-04-27 | |
US60/796,318 | 2006-04-27 | ||
US79950406P | 2006-05-10 | 2006-05-10 | |
US60/799,504 | 2006-05-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007127445A2 true WO2007127445A2 (en) | 2007-11-08 |
WO2007127445A3 WO2007127445A3 (en) | 2008-02-21 |
Family
ID=38473616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/010364 WO2007127445A2 (en) | 2006-04-27 | 2007-04-27 | Process for the preparation of cinacalcet base |
Country Status (12)
Country | Link |
---|---|
US (1) | US7449603B2 (en) |
EP (1) | EP1915335B1 (en) |
JP (1) | JP5027214B2 (en) |
KR (1) | KR20090025189A (en) |
AT (1) | ATE447546T1 (en) |
CA (1) | CA2649616A1 (en) |
DE (1) | DE602007003067D1 (en) |
ES (1) | ES2333993T3 (en) |
IL (1) | IL194719A0 (en) |
MX (1) | MX2008013684A (en) |
TW (1) | TW200808297A (en) |
WO (1) | WO2007127445A2 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008117299A1 (en) * | 2007-03-26 | 2008-10-02 | Macleods Pharmaceuticals Limited | Process for preparing cinacalcet hydrochloride |
EP2022777A3 (en) * | 2007-06-22 | 2009-06-17 | Dipharma Francis S.r.l. | A process for the preparation of cinacalcet |
WO2009153814A1 (en) * | 2008-06-18 | 2009-12-23 | Erregierre S.P.A. | A process for the synthesis of cinacalcet hydrochloride |
WO2010067204A1 (en) | 2008-12-08 | 2010-06-17 | Actavis Group Ptc Ehf | Highly pure cinacalcet or a pharmaceutically acceptable salt thereof |
WO2010103531A2 (en) | 2009-03-09 | 2010-09-16 | Megafine Pharma (P) Ltd. | A new method for the preparation of cinacalcet and new intermediates thereof |
WO2012007954A1 (en) | 2010-07-16 | 2012-01-19 | Hetero Research Foundation | Process for cinacalcet hydrochloride |
US8183415B2 (en) | 2007-06-21 | 2012-05-22 | Amgen, Inc. | Methods of synthesizing cinacalcet and salts thereof |
US8415501B2 (en) | 2006-03-23 | 2013-04-09 | Amgen, Inc. | Methods and compositions for making and using polymorphs of cinacalcet |
US9290439B2 (en) | 2012-09-07 | 2016-03-22 | Produits Chimiques Auxiliaires Et De Synthese | Process for preparing cinacalcet and pharmaceutically acceptable salts thereof |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101522173A (en) * | 2006-09-01 | 2009-09-02 | 特瓦制药工业有限公司 | Solid composites of a calicum receptor-active compound |
WO2008035381A2 (en) * | 2006-09-22 | 2008-03-27 | Ind-Swift Laboratories Limited | Process for the preparation of amine derivatives as calcimimetics |
US9050471B2 (en) | 2008-07-11 | 2015-06-09 | Medtronic, Inc. | Posture state display on medical device user interface |
WO2010049293A2 (en) * | 2008-10-28 | 2010-05-06 | Zach System S.P.A. | Process for preparing cinacalcet |
WO2010128388A2 (en) | 2009-05-08 | 2010-11-11 | Aurobindo Pharma Limited | An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet |
JP5685594B2 (en) | 2009-09-10 | 2015-03-18 | ザック システム エス.ピー.エー.ZaCh System S.p.A. | Method for producing cinacalcet |
US8579834B2 (en) | 2010-01-08 | 2013-11-12 | Medtronic, Inc. | Display of detected patient posture state |
CZ2011770A3 (en) | 2011-11-25 | 2013-01-16 | Zentiva, K.S. | Process for preparing cinacalcet |
CN102617328A (en) * | 2012-03-13 | 2012-08-01 | 湖北远成药业有限公司 | Preparation method of hydrocinnamic acid |
CN103450027B (en) | 2012-05-29 | 2015-07-29 | 上海京新生物医药有限公司 | The preparation method of cinacalcet hydrochloride |
CN104030941B (en) * | 2014-06-23 | 2016-04-27 | 常州大学 | A kind of 3-(4-hydroxy phenyl) synthetic method of propionic acid amide |
CN104693020A (en) * | 2015-03-11 | 2015-06-10 | 岳阳新华达制药有限公司 | Preparation method of 3-(3-trifluoromethylphenyl) propionic acid serving as cinacalcethdrochloride intermediate |
CN106810452B (en) * | 2017-01-13 | 2018-12-28 | 华北水利水电大学 | A kind of preparation method of cinacalcet hydrochloride |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6211244B1 (en) * | 1994-10-21 | 2001-04-03 | Nps Pharmaceuticals, Inc. | Calcium receptor-active compounds |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4966988A (en) | 1989-02-17 | 1990-10-30 | Chevron Research Company | Process for preparing acetonitrile 3-trifluoromethyl benzene |
US6031003A (en) | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US6011068A (en) | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5648541A (en) | 1995-09-28 | 1997-07-15 | Nps Pharmaceuticals, Inc. | Chiral reductions of imines leading to the syntheses of optically active amines |
JP5026077B2 (en) | 2003-09-12 | 2012-09-12 | アムジエン・インコーポレーテツド | Calcium receptor-active compound rapid dissolution formulation |
US20050234261A1 (en) | 2004-04-14 | 2005-10-20 | Honeywell International Inc. | Process for preparing cinnamic acids and alkyl esters thereof |
CA2601669A1 (en) | 2005-03-17 | 2006-09-28 | Amgen Inc. | Methods of decreasing calcification |
ES2332016T3 (en) | 2005-05-16 | 2010-01-22 | Teva Pharmaceutical Industries Ltd. | PROCEDURE FOR THE PREPARATION OF CINACALCET HYDROCLORIDE. |
-
2007
- 2007-04-27 WO PCT/US2007/010364 patent/WO2007127445A2/en active Application Filing
- 2007-04-27 KR KR1020087025917A patent/KR20090025189A/en not_active Application Discontinuation
- 2007-04-27 JP JP2009507844A patent/JP5027214B2/en not_active Expired - Fee Related
- 2007-04-27 ES ES07756140T patent/ES2333993T3/en active Active
- 2007-04-27 DE DE602007003067T patent/DE602007003067D1/en active Active
- 2007-04-27 EP EP07756140A patent/EP1915335B1/en not_active Revoked
- 2007-04-27 TW TW096115090A patent/TW200808297A/en unknown
- 2007-04-27 US US11/796,686 patent/US7449603B2/en not_active Expired - Fee Related
- 2007-04-27 AT AT07756140T patent/ATE447546T1/en not_active IP Right Cessation
- 2007-04-27 MX MX2008013684A patent/MX2008013684A/en not_active Application Discontinuation
- 2007-04-27 CA CA002649616A patent/CA2649616A1/en not_active Abandoned
-
2008
- 2008-10-22 IL IL194719A patent/IL194719A0/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6211244B1 (en) * | 1994-10-21 | 2001-04-03 | Nps Pharmaceuticals, Inc. | Calcium receptor-active compounds |
Non-Patent Citations (2)
Title |
---|
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002451055 retrieved from XFIRE Database accession no. 3304358, 3304356 & PHARMAZIE, vol. 59, no. 10, 2004, pages 744-752, * |
WANG X ET AL: "Synthesis of Cinacalcet congeners" TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 45, no. 45, 1 November 2004 (2004-11-01), pages 8355-8358, XP004593872 ISSN: 0040-4039 cited in the application * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8415501B2 (en) | 2006-03-23 | 2013-04-09 | Amgen, Inc. | Methods and compositions for making and using polymorphs of cinacalcet |
WO2008117299A1 (en) * | 2007-03-26 | 2008-10-02 | Macleods Pharmaceuticals Limited | Process for preparing cinacalcet hydrochloride |
US8183415B2 (en) | 2007-06-21 | 2012-05-22 | Amgen, Inc. | Methods of synthesizing cinacalcet and salts thereof |
EP2022777A3 (en) * | 2007-06-22 | 2009-06-17 | Dipharma Francis S.r.l. | A process for the preparation of cinacalcet |
WO2009153814A1 (en) * | 2008-06-18 | 2009-12-23 | Erregierre S.P.A. | A process for the synthesis of cinacalcet hydrochloride |
US8614354B2 (en) | 2008-06-18 | 2013-12-24 | Erregierre S.P.A. | Process for the synthesis of cinacalcet hydrochloride |
WO2010067204A1 (en) | 2008-12-08 | 2010-06-17 | Actavis Group Ptc Ehf | Highly pure cinacalcet or a pharmaceutically acceptable salt thereof |
US8575395B2 (en) | 2009-03-09 | 2013-11-05 | Amneal Pharmaceuticals, LLC | Method for the preparation of cinacalcet and intermediates and impurities thereof |
WO2010103531A3 (en) * | 2009-03-09 | 2011-03-31 | Megafine Pharma (P) Ltd. | A new method for the preparation of cinacalcet and new intermediates thereof |
WO2010103531A2 (en) | 2009-03-09 | 2010-09-16 | Megafine Pharma (P) Ltd. | A new method for the preparation of cinacalcet and new intermediates thereof |
US8969623B2 (en) | 2009-03-09 | 2015-03-03 | Amneal Pharmaceuticals, LLC | Method for the preparation of cinacalcet and intermediates and impurities thereof |
WO2012007954A1 (en) | 2010-07-16 | 2012-01-19 | Hetero Research Foundation | Process for cinacalcet hydrochloride |
US8921606B2 (en) | 2010-07-16 | 2014-12-30 | Hetero Research Foundation | Process for cinacalcet hydrochloride |
US9290439B2 (en) | 2012-09-07 | 2016-03-22 | Produits Chimiques Auxiliaires Et De Synthese | Process for preparing cinacalcet and pharmaceutically acceptable salts thereof |
US9598350B2 (en) | 2012-09-07 | 2017-03-21 | Produits Chimiques Auxiliaries Et De Synthese | Process for preparing cinacalcet and pharmaceutically acceptable salts thereof |
Also Published As
Publication number | Publication date |
---|---|
EP1915335B1 (en) | 2009-11-04 |
DE602007003067D1 (en) | 2009-12-17 |
US7449603B2 (en) | 2008-11-11 |
JP2009535349A (en) | 2009-10-01 |
TW200808297A (en) | 2008-02-16 |
CA2649616A1 (en) | 2007-11-08 |
ES2333993T3 (en) | 2010-03-03 |
EP1915335A2 (en) | 2008-04-30 |
ATE447546T1 (en) | 2009-11-15 |
JP5027214B2 (en) | 2012-09-19 |
KR20090025189A (en) | 2009-03-10 |
IL194719A0 (en) | 2009-08-03 |
MX2008013684A (en) | 2008-11-06 |
US20070259964A1 (en) | 2007-11-08 |
WO2007127445A3 (en) | 2008-02-21 |
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