WO2007123883A3 - Oral dosage formulations and methods of preparing the same - Google Patents

Oral dosage formulations and methods of preparing the same Download PDF

Info

Publication number
WO2007123883A3
WO2007123883A3 PCT/US2007/009331 US2007009331W WO2007123883A3 WO 2007123883 A3 WO2007123883 A3 WO 2007123883A3 US 2007009331 W US2007009331 W US 2007009331W WO 2007123883 A3 WO2007123883 A3 WO 2007123883A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
oral dosage
dosage form
preparing
same
Prior art date
Application number
PCT/US2007/009331
Other languages
French (fr)
Other versions
WO2007123883A2 (en
Inventor
Grant Wayne Heinicke
Original Assignee
Actavis Group Ptc Hf
Grant Wayne Heinicke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actavis Group Ptc Hf, Grant Wayne Heinicke filed Critical Actavis Group Ptc Hf
Priority to EP07755562A priority Critical patent/EP2010161A2/en
Publication of WO2007123883A2 publication Critical patent/WO2007123883A2/en
Publication of WO2007123883A3 publication Critical patent/WO2007123883A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed herein are methods and compositions suitable for providing zero-order release of active agents. Disclosed herein is a multiparticulate oral dosage form comprising a plurality of pulsed-release pellets, wherein the dosage form releases the active agent at a substantially constant rate following a lag time. The dosage form comprises a combination ensemble of pellets produced by combining 2 to 8 individual ensembles of pulsed-release pellets having a particular T50 and dissolution profile.
PCT/US2007/009331 2006-04-17 2007-04-17 Oral dosage formulations and methods of preparing the same WO2007123883A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07755562A EP2010161A2 (en) 2006-04-17 2007-04-17 Oral dosage formulations and methods of preparing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79244206P 2006-04-17 2006-04-17
US60/792,442 2006-04-17

Publications (2)

Publication Number Publication Date
WO2007123883A2 WO2007123883A2 (en) 2007-11-01
WO2007123883A3 true WO2007123883A3 (en) 2008-03-27

Family

ID=38537695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/009331 WO2007123883A2 (en) 2006-04-17 2007-04-17 Oral dosage formulations and methods of preparing the same

Country Status (3)

Country Link
US (2) US20070243252A1 (en)
EP (1) EP2010161A2 (en)
WO (1) WO2007123883A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1551372T3 (en) 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES
WO2007149438A2 (en) 2006-06-19 2007-12-27 Alpharma, Inc. Pharmaceutical compositions
WO2008063301A2 (en) * 2006-10-11 2008-05-29 Alpharma, Inc. Pharmaceutical compositions
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
EP2293782B1 (en) * 2008-05-06 2015-08-12 Dexcel Pharma Technologies Ltd. Stable benzimidazole formulation
TWI590821B (en) * 2011-01-18 2017-07-11 輝瑞有限公司 Solid molecular dispersion
US20210145777A1 (en) * 2017-06-16 2021-05-20 Altibio, Inc. Modified-release tiopronin compositions, kits and methods for treating cystinuria and related disorders
CN114425046B (en) * 2021-12-16 2023-10-20 南通联亚药业股份有限公司 Diltiazem hydrochloride sustained-release capsule

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0365947A1 (en) * 1988-10-26 1990-05-02 Dib Limited Novel dosage form
WO1998051287A1 (en) * 1997-05-15 1998-11-19 Bai Jane Pei Fan Pulsatile drug delivery system
WO2000025752A1 (en) * 1998-11-02 2000-05-11 Church, Marla, J. Multiparticulate modified release composition
WO2004045589A1 (en) * 2002-11-15 2004-06-03 Elan Pharmaceuticals, Inc. Modified release composition comprising a short-acting hypnotic for treatment of sleep disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5260068A (en) * 1992-05-04 1993-11-09 Anda Sr Pharmaceuticals Inc. Multiparticulate pulsatile drug delivery system
US5834024A (en) * 1995-01-05 1998-11-10 Fh Faulding & Co. Limited Controlled absorption diltiazem pharmaceutical formulation
US6368628B1 (en) * 2000-05-26 2002-04-09 Pharma Pass Llc Sustained release pharmaceutical composition free of food effect
PL1638529T3 (en) * 2003-06-16 2017-03-31 Andrx Pharmaceuticals, Llc. Oral extended-release composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0365947A1 (en) * 1988-10-26 1990-05-02 Dib Limited Novel dosage form
WO1998051287A1 (en) * 1997-05-15 1998-11-19 Bai Jane Pei Fan Pulsatile drug delivery system
WO2000025752A1 (en) * 1998-11-02 2000-05-11 Church, Marla, J. Multiparticulate modified release composition
WO2004045589A1 (en) * 2002-11-15 2004-06-03 Elan Pharmaceuticals, Inc. Modified release composition comprising a short-acting hypnotic for treatment of sleep disorders

Also Published As

Publication number Publication date
EP2010161A2 (en) 2009-01-07
WO2007123883A2 (en) 2007-11-01
US20070243252A1 (en) 2007-10-18
US20070243250A1 (en) 2007-10-18

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