WO2007121578A1 - Indole amide derivatives as ep4 receptor antagonists - Google Patents
Indole amide derivatives as ep4 receptor antagonists Download PDFInfo
- Publication number
- WO2007121578A1 WO2007121578A1 PCT/CA2007/000689 CA2007000689W WO2007121578A1 WO 2007121578 A1 WO2007121578 A1 WO 2007121578A1 CA 2007000689 W CA2007000689 W CA 2007000689W WO 2007121578 A1 WO2007121578 A1 WO 2007121578A1
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- Prior art keywords
- ethyl
- amino
- carbonyl
- benzoic acid
- compound according
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- 0 *C(c1cccc2c1cc[n]2)=O Chemical compound *C(c1cccc2c1cc[n]2)=O 0.000 description 3
- PGZZCHKXCSVROB-UHFFFAOYSA-N CC(c(cc1)ccc1C(O)=O)NC(c1c2[n](Cc3cc(Cl)ccc3)nnc2cc(Cl)c1)=O Chemical compound CC(c(cc1)ccc1C(O)=O)NC(c1c2[n](Cc3cc(Cl)ccc3)nnc2cc(Cl)c1)=O PGZZCHKXCSVROB-UHFFFAOYSA-N 0.000 description 1
- SOYQNFULUOIDHB-UHFFFAOYSA-N COC(C1=C2N(Cc3cccc(C(F)(F)F)c3)C=CC2CC=C1)=O Chemical compound COC(C1=C2N(Cc3cccc(C(F)(F)F)c3)C=CC2CC=C1)=O SOYQNFULUOIDHB-UHFFFAOYSA-N 0.000 description 1
- NGDPOXCYWFJWLG-KRWDZBQOSA-N C[C@@H](c(cc1)ccc1C(OC)=O)NC(c1c2[n](Cc3cc(C(F)(F)F)ccc3)ccc2ccc1)=O Chemical compound C[C@@H](c(cc1)ccc1C(OC)=O)NC(c1c2[n](Cc3cc(C(F)(F)F)ccc3)ccc2ccc1)=O NGDPOXCYWFJWLG-KRWDZBQOSA-N 0.000 description 1
- BHQIOJZIEUFKPV-UHFFFAOYSA-N OC(c1c2[n](Cc3cccc(C(F)(F)F)c3)ccc2ccc1)=O Chemical compound OC(c1c2[n](Cc3cccc(C(F)(F)F)c3)ccc2ccc1)=O BHQIOJZIEUFKPV-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D249/18—Benzotriazoles
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07719615A EP2013169B1 (en) | 2006-04-24 | 2007-04-23 | Indole amide derivatives as ep4 receptor antagonists |
AU2007242018A AU2007242018B2 (en) | 2006-04-24 | 2007-04-23 | Indole amide derivatives as EP4 receptor antagonists |
US12/225,544 US7968578B2 (en) | 2006-04-24 | 2007-04-23 | Indole amide derivatives as EP4 receptor antagonists |
ES07719615T ES2392192T3 (en) | 2006-04-24 | 2007-04-23 | Indole amide derivatives as EP4 receptor antagonists |
JP2009506874A JP5244091B2 (en) | 2006-04-24 | 2007-04-23 | Indoleamide derivatives as EP4 receptor antagonists |
CA002648729A CA2648729A1 (en) | 2006-04-24 | 2007-04-23 | Indole amide derivatives as ep4 receptor antagonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79455706P | 2006-04-24 | 2006-04-24 | |
US60/794,557 | 2006-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007121578A1 true WO2007121578A1 (en) | 2007-11-01 |
Family
ID=38624503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2007/000689 WO2007121578A1 (en) | 2006-04-24 | 2007-04-23 | Indole amide derivatives as ep4 receptor antagonists |
Country Status (7)
Country | Link |
---|---|
US (1) | US7968578B2 (en) |
EP (1) | EP2013169B1 (en) |
JP (1) | JP5244091B2 (en) |
AU (1) | AU2007242018B2 (en) |
CA (1) | CA2648729A1 (en) |
ES (1) | ES2392192T3 (en) |
WO (1) | WO2007121578A1 (en) |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008104055A1 (en) * | 2007-02-26 | 2008-09-04 | Merck Frosst Canada Ltd. | Indole and indoline cyclopropyl amide derivatives as ep4 receptor antagonists |
WO2009005076A1 (en) | 2007-07-03 | 2009-01-08 | Astellas Pharma Inc. | Amide compound |
WO2009139373A1 (en) | 2008-05-14 | 2009-11-19 | アステラス製薬株式会社 | Amide compound |
WO2010019796A1 (en) | 2008-08-14 | 2010-02-18 | Chemietek, Llc | Heterocyclic amide derivatives as ep4 receptor antagonists |
WO2010087425A1 (en) | 2009-01-30 | 2010-08-05 | 国立大学法人京都大学 | Prostate cancer progression inhibitor and progression inhibition method |
US7994331B2 (en) | 2005-07-13 | 2011-08-09 | Msd K.K. | Heterocycle-substituted benzimidazole derivative |
WO2012076063A1 (en) | 2010-12-10 | 2012-06-14 | Rottapharm S.P.A. | Pyridine amide derivatives as ep4 receptor antagonists |
WO2013004290A1 (en) | 2011-07-04 | 2013-01-10 | Rottapharm S.P.A. | Cyclic amine derivatives as ep4 receptor antagonists |
WO2014086739A1 (en) | 2012-12-06 | 2014-06-12 | Bayer Pharma Aktiengesellschaft | Novel benzimidazole derivatives as ep4 antagonists |
WO2014200075A1 (en) | 2013-06-12 | 2014-12-18 | 科研製薬株式会社 | 4-alkynyl imidazole derivative and medicine comprising same as active ingredient |
US8962659B2 (en) | 2012-06-29 | 2015-02-24 | Eli Lilly And Company | Phenoxyethyl piperidine compounds |
WO2015048553A1 (en) * | 2013-09-27 | 2015-04-02 | Allergan, Inc. | Compounds and methods for skin repair |
US9371289B2 (en) | 2013-05-17 | 2016-06-21 | Eli Lilly And Company | Phenoxyethyl dihydro-1H-isoquinoline compounds |
WO2017066633A1 (en) * | 2015-10-16 | 2017-04-20 | Eisai R&D Management Co., Ltd. | Ep4 antagonists |
US9776964B2 (en) | 2013-12-17 | 2017-10-03 | Eli Lilly And Company | Phenoxyethyl cyclic amine derivatives and their activity as EP4 receptor modulators |
WO2018162562A1 (en) | 2017-03-10 | 2018-09-13 | Bayer Pharma Aktiengesellschaft | Use of an ep4 antagonist for the treatment of inflammatory pain |
WO2018210995A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | N-substituted indole derivatives |
WO2019038156A1 (en) | 2017-08-22 | 2019-02-28 | Bayer Pharma Aktiengesellschaft | Use of an ep4 antagonist for the treatment of arthritis |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2035376B1 (en) * | 2006-06-12 | 2014-08-27 | Merck Canada Inc. | Indoline amide derivatives as ep4 receptor ligands |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4221815A (en) * | 1975-01-03 | 1980-09-09 | Hoechst Aktiengesellschaft | Benzoic acids, their derivatives and process for preparing them |
EP0166591A2 (en) * | 1984-06-25 | 1986-01-02 | Merck Frosst Canada Inc. | Indole-2-alkanoic acids and their use as prostaglandin antagonists |
US20050065188A1 (en) * | 2003-09-03 | 2005-03-24 | Kazunari Nakao | Aryl or heteroaryl amide compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62138469A (en) * | 1985-12-11 | 1987-06-22 | Yoshitomi Pharmaceut Ind Ltd | Indole derivative |
US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
GB0031315D0 (en) * | 2000-12-21 | 2001-02-07 | Glaxo Group Ltd | Indole derivatives |
US20070123561A1 (en) * | 2003-10-06 | 2007-05-31 | Dennis Lee | Preparation of 1,7-disubstituted azabensimidazoles as kinase inhibitors |
WO2005080367A1 (en) * | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Ep2 receptor agonists |
US7572807B2 (en) * | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
-
2007
- 2007-04-23 EP EP07719615A patent/EP2013169B1/en active Active
- 2007-04-23 CA CA002648729A patent/CA2648729A1/en not_active Abandoned
- 2007-04-23 WO PCT/CA2007/000689 patent/WO2007121578A1/en active Application Filing
- 2007-04-23 ES ES07719615T patent/ES2392192T3/en active Active
- 2007-04-23 AU AU2007242018A patent/AU2007242018B2/en not_active Ceased
- 2007-04-23 JP JP2009506874A patent/JP5244091B2/en not_active Expired - Fee Related
- 2007-04-23 US US12/225,544 patent/US7968578B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4221815A (en) * | 1975-01-03 | 1980-09-09 | Hoechst Aktiengesellschaft | Benzoic acids, their derivatives and process for preparing them |
EP0166591A2 (en) * | 1984-06-25 | 1986-01-02 | Merck Frosst Canada Inc. | Indole-2-alkanoic acids and their use as prostaglandin antagonists |
US20050065188A1 (en) * | 2003-09-03 | 2005-03-24 | Kazunari Nakao | Aryl or heteroaryl amide compounds |
Non-Patent Citations (1)
Title |
---|
See also references of EP2013169A4 * |
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Also Published As
Publication number | Publication date |
---|---|
AU2007242018B2 (en) | 2012-07-19 |
EP2013169A4 (en) | 2010-12-01 |
US20090253756A1 (en) | 2009-10-08 |
ES2392192T3 (en) | 2012-12-05 |
CA2648729A1 (en) | 2007-11-01 |
JP5244091B2 (en) | 2013-07-24 |
EP2013169B1 (en) | 2012-08-22 |
AU2007242018A1 (en) | 2007-11-01 |
JP2009534430A (en) | 2009-09-24 |
EP2013169A1 (en) | 2009-01-14 |
US7968578B2 (en) | 2011-06-28 |
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