WO2007120787A3 - Methods of treating, diagnosing or detecting cancers associated with liv-1 overexpression - Google Patents

Methods of treating, diagnosing or detecting cancers associated with liv-1 overexpression Download PDF

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Publication number
WO2007120787A3
WO2007120787A3 PCT/US2007/009063 US2007009063W WO2007120787A3 WO 2007120787 A3 WO2007120787 A3 WO 2007120787A3 US 2007009063 W US2007009063 W US 2007009063W WO 2007120787 A3 WO2007120787 A3 WO 2007120787A3
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WO
WIPO (PCT)
Prior art keywords
methods
diagnosing
treating
liv
overexpression
Prior art date
Application number
PCT/US2007/009063
Other languages
French (fr)
Other versions
WO2007120787A2 (en
Inventor
Mary J Jantapour
Guoying Yu
Robert To
Vivien Chan
Deborah Zimmerman
Original Assignee
Novartis Vaccines & Diagnostic
Mary J Jantapour
Guoying Yu
Robert To
Vivien Chan
Deborah Zimmerman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic, Mary J Jantapour, Guoying Yu, Robert To, Vivien Chan, Deborah Zimmerman filed Critical Novartis Vaccines & Diagnostic
Priority to JP2009505486A priority Critical patent/JP2009541208A/en
Priority to EP07755364A priority patent/EP2012827A2/en
Priority to AU2007238636A priority patent/AU2007238636A1/en
Priority to MX2008013121A priority patent/MX2008013121A/en
Priority to CA002650126A priority patent/CA2650126A1/en
Priority to BRPI0710616-5A priority patent/BRPI0710616A2/en
Priority to US12/296,833 priority patent/US20100196377A1/en
Publication of WO2007120787A2 publication Critical patent/WO2007120787A2/en
Priority to TNP2008000401A priority patent/TNSN08401A1/en
Priority to NO20084795A priority patent/NO20084795L/en
Publication of WO2007120787A3 publication Critical patent/WO2007120787A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides, inter alia, methods for treating cancer, compositions for treating cancer, and methods and compositions for diagnosing and/or detecting cancer. In particular, the present invention provides compositions and methods for treating, diagnosing and detecting cancers associated with LIV-1 overexpression.
PCT/US2007/009063 2006-04-13 2007-04-12 Methods of treating, diagnosing or detecting cancers associated with liv-1 overexpression WO2007120787A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2009505486A JP2009541208A (en) 2006-04-13 2007-04-12 How to treat, diagnose, or detect cancer
EP07755364A EP2012827A2 (en) 2006-04-13 2007-04-12 Methods of treating, diagnosing or detecting cancer
AU2007238636A AU2007238636A1 (en) 2006-04-13 2007-04-12 Methods of treating, diagnosing or detecting cancer
MX2008013121A MX2008013121A (en) 2006-04-13 2007-04-12 Methods of treating, diagnosing or detecting cancer.
CA002650126A CA2650126A1 (en) 2006-04-13 2007-04-12 Methods of treating, diagnosing or detecting cancer
BRPI0710616-5A BRPI0710616A2 (en) 2006-04-13 2007-04-12 methods to treat, diagnose or detect cancer
US12/296,833 US20100196377A1 (en) 2006-04-13 2007-04-12 Methods of treating, diagnosing or detecting cancer
TNP2008000401A TNSN08401A1 (en) 2006-04-13 2008-10-13 Methods of treating diagnosing or detecting cancer
NO20084795A NO20084795L (en) 2006-04-13 2008-11-13 Procedure for treating, diagnosing or detecting cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79187106P 2006-04-13 2006-04-13
US60/791,871 2006-04-13

Publications (2)

Publication Number Publication Date
WO2007120787A2 WO2007120787A2 (en) 2007-10-25
WO2007120787A3 true WO2007120787A3 (en) 2009-04-30

Family

ID=38610188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/009063 WO2007120787A2 (en) 2006-04-13 2007-04-12 Methods of treating, diagnosing or detecting cancers associated with liv-1 overexpression

Country Status (15)

Country Link
US (1) US20100196377A1 (en)
EP (2) EP2407483A1 (en)
JP (1) JP2009541208A (en)
KR (1) KR20090010194A (en)
CN (1) CN101622273A (en)
AU (1) AU2007238636A1 (en)
BR (1) BRPI0710616A2 (en)
CA (1) CA2650126A1 (en)
MA (1) MA30393B1 (en)
MX (1) MX2008013121A (en)
NO (1) NO20084795L (en)
TN (1) TNSN08401A1 (en)
TW (1) TW200813231A (en)
WO (1) WO2007120787A2 (en)
ZA (1) ZA200808669B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040141983A1 (en) 1999-03-15 2004-07-22 Protein Design Labs, Inc. Compositions against cancer antigen LIV-1 and uses thereof
WO2004067564A2 (en) 2003-01-29 2004-08-12 Protein Design Labs, Inc. Compositions against cancer antigen liv-1 and uses thereof
EP2493916B1 (en) * 2009-10-26 2016-06-08 Externautics S.p.A. Lung tumor markers and methods of use thereof
SG10201912646UA (en) 2010-12-06 2020-02-27 Seattle Genetics Inc Humanized antibodies to liv-1 and use of same to treat cancer
AU2015222881A1 (en) * 2014-02-27 2016-08-04 The Procter & Gamble Company Method for evaluating bioavailable zinc
KR20160045471A (en) 2014-10-17 2016-04-27 대산안전산업 주식회사 Soundproof panel
MA45324A (en) 2016-03-15 2019-01-23 Seattle Genetics Inc POLYTHERAPY USING ADC-LIV1 AND CHEMOTHERAPEUTIC AGENT
MX2020005640A (en) * 2017-12-01 2020-08-20 Seattle Genetics Inc Humanized anti-liv1 antibodies for the treatment of breast cancer.
CN111289756A (en) * 2018-12-10 2020-06-16 北京师范大学 Urine marker related to lung metastasis and tumor formation of ovarian cancer
GB201908208D0 (en) * 2019-06-10 2019-07-24 Univ College Cardiff Consultants Ltd An anti-mitotic agent
WO2021047507A1 (en) * 2019-09-09 2021-03-18 浙江百寿康迪生物医药有限责任公司 Method for identifying substance capable of affecting aging

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055178A2 (en) * 2000-01-25 2001-08-02 Genentech, Inc. Liv-1 related protein, polynucleotides encoding the same and use thereof for treatment of cancer
WO2004066933A2 (en) * 2003-01-27 2004-08-12 Biogen Idec Ma Inc. Compositions and methods for treating cancer using igsf9 and liv-1
WO2004067564A2 (en) * 2003-01-29 2004-08-12 Protein Design Labs, Inc. Compositions against cancer antigen liv-1 and uses thereof
WO2004106495A2 (en) * 2003-05-29 2004-12-09 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
WO2005063301A1 (en) * 2003-12-26 2005-07-14 Toshio Hirano Emt inducer

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
WO1981001145A1 (en) 1979-10-18 1981-04-30 Univ Illinois Hydrolytic enzyme-activatible pro-drugs
JPS5896026A (en) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd Novel urokinase derivative, its preparation and thrombolytic agent containing the same
EP0098110B1 (en) 1982-06-24 1989-10-18 NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD Long-acting composition
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
GB8705477D0 (en) 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US5637677A (en) 1987-07-16 1997-06-10 The Trustees Of The University Of Pennsylvania Biologically active compounds and methods of constructing and using the same
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
AU631802B2 (en) 1988-06-14 1992-12-10 Cetus Oncology Corporation Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
ZA902949B (en) 1989-05-05 1992-02-26 Res Dev Foundation A novel antibody delivery system for biological response modifiers
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
SG48759A1 (en) 1990-01-12 2002-07-23 Abgenix Inc Generation of xenogenic antibodies
US5314995A (en) 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
EP0521985B1 (en) 1990-03-20 1997-09-24 The Trustees Of Columbia University In The City Of New York Chimeric antibodies with receptor binding ligands in place of their constant region
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
EP0814159B1 (en) 1990-08-29 2005-07-27 GenPharm International, Inc. Transgenic mice capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
GB9022543D0 (en) 1990-10-17 1990-11-28 Wellcome Found Antibody production
AU660297B2 (en) 1990-11-09 1995-06-22 Stephen D. Gillies Cytokine immunoconjugates
US5264586A (en) 1991-07-17 1993-11-23 The Scripps Research Institute Analogs of calicheamicin gamma1I, method of making and using the same
WO1993011794A1 (en) 1991-12-13 1993-06-24 Xoma Corporation Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
ZA932522B (en) 1992-04-10 1993-12-20 Res Dev Foundation Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
CA2140638C (en) 1992-07-24 2010-05-04 Raju Kucherlapati Generation of xenogeneic antibodies
DK0669836T3 (en) 1992-11-13 1996-10-14 Idec Pharma Corp Therapeutic use of chimeric and radiolabeled antibodies and human B lymphocyte restricted differentiation antigen for the treatment of B cell lymphoma
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
CA2132500A1 (en) * 1994-09-20 1996-03-21 David Lockwood Manning Methods for predicting the behaviour of breast tumours
US6091001A (en) 1995-03-29 2000-07-18 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
CA2219361C (en) 1995-04-27 2012-02-28 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
KR100942002B1 (en) 1996-12-03 2010-02-12 암젠 프레몬트 인코포레이티드 Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
US5830698A (en) 1997-03-14 1998-11-03 Idec Pharmaceuticals Corporation Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
DE19956568A1 (en) 1999-01-30 2000-08-17 Roland Kreutzer Method and medicament for inhibiting the expression of a given gene
US6475220B1 (en) 1999-10-15 2002-11-05 Whiteside Biomechanics, Inc. Spinal cable system
AU1086501A (en) 1999-10-15 2001-04-30 Carnegie Institution Of Washington Rna interference pathway genes as tools for targeted genetic interference
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US6997863B2 (en) 2001-07-25 2006-02-14 Triton Biosystems, Inc. Thermotherapy via targeted delivery of nanoscale magnetic particles
US7074175B2 (en) 2001-07-25 2006-07-11 Erik Schroeder Handy Thermotherapy via targeted delivery of nanoscale magnetic particles
WO2003026577A2 (en) 2001-09-24 2003-04-03 Seattle Genetics, Inc. P-amidobenzylethers in drug delivery agents
BRPI0410748B8 (en) 2003-05-20 2021-05-25 Immunogen Inc maytansinoid compounds, their pharmaceutical compositions, methods of esterification of maytansinoids, as well as methods for their production, and maytansinoid-cell binding agent conjugate
US7504225B2 (en) * 2005-05-12 2009-03-17 Applied Genomics, Inc. Reagents and methods for use in cancer diagnosis, classification and therapy

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055178A2 (en) * 2000-01-25 2001-08-02 Genentech, Inc. Liv-1 related protein, polynucleotides encoding the same and use thereof for treatment of cancer
WO2004066933A2 (en) * 2003-01-27 2004-08-12 Biogen Idec Ma Inc. Compositions and methods for treating cancer using igsf9 and liv-1
WO2004067564A2 (en) * 2003-01-29 2004-08-12 Protein Design Labs, Inc. Compositions against cancer antigen liv-1 and uses thereof
WO2004106495A2 (en) * 2003-05-29 2004-12-09 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
WO2005063301A1 (en) * 2003-12-26 2005-07-14 Toshio Hirano Emt inducer
EP1709976A1 (en) * 2003-12-26 2006-10-11 Toshio Hirano Emt- inducing agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHOWANADISAI W ET AL: "Zinc deficiency is associated with increased brain zinc import and LIV-1 expression and decreased ZnT-1 expression in neonatal rats", JOURNAL OF NUTRITION, WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, PHILADELPHIA, PA,, US, vol. 135, no. 5, May 2005 (2005-05-01), pages 1002 - 1007, XP001207366, ISSN: 0022-3166 *
KASPER G ET AL: "Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients", INTERNATIONAL JOURNAL OF CANCER, vol. 117, no. 6, December 2005 (2005-12-01), pages 961 - 973, XP002457315, ISSN: 0020-7136 *
TAYLOR K M ET AL: "Zinc transporter LIV-1: a link between cellular development and cancer progression", TRENDS IN ENDOCRINOLOGY AND METABOLISM, ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, US, vol. 15, no. 10, December 2004 (2004-12-01), pages 461 - 463, XP004640893, ISSN: 1043-2760 *
WIMMER U ET AL: "Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione", NUCLEIC ACIDS RESEARCH, vol. 33, no. 18, 2005, pages 5715 - 5727, XP002457325, ISSN: 0305-1048 *
YAMASHITA S ET AL: "Zinc transporter LIV1 controls epithelial-mesenchymal transition in zebrafish gastrula organizer", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 429, 20 May 2004 (2004-05-20), pages 298 - 302, XP002990283, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
TW200813231A (en) 2008-03-16
JP2009541208A (en) 2009-11-26
CA2650126A1 (en) 2007-10-25
ZA200808669B (en) 2009-10-28
MA30393B1 (en) 2009-05-04
CN101622273A (en) 2010-01-06
EP2407483A1 (en) 2012-01-18
BRPI0710616A2 (en) 2011-08-16
TNSN08401A1 (en) 2010-04-14
KR20090010194A (en) 2009-01-29
NO20084795L (en) 2009-01-13
MX2008013121A (en) 2009-03-25
WO2007120787A2 (en) 2007-10-25
EP2012827A2 (en) 2009-01-14
US20100196377A1 (en) 2010-08-05
AU2007238636A1 (en) 2007-10-25

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