WO2007118849A3 - Methods and means for assessing hiv gag/protease inhibitor therapy - Google Patents

Methods and means for assessing hiv gag/protease inhibitor therapy Download PDF

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Publication number
WO2007118849A3
WO2007118849A3 PCT/EP2007/053613 EP2007053613W WO2007118849A3 WO 2007118849 A3 WO2007118849 A3 WO 2007118849A3 EP 2007053613 W EP2007053613 W EP 2007053613W WO 2007118849 A3 WO2007118849 A3 WO 2007118849A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
hiv gag
protease inhibitor
inhibitor therapy
treatment
Prior art date
Application number
PCT/EP2007/053613
Other languages
French (fr)
Other versions
WO2007118849A2 (en
Inventor
Baere Inky Paul Madeleine De
Guenter Kraus
Laurence Tatiana Rimsky
Bart Anna Julien Maes
Hilde Azijn
Bethune Marie-Pierre T M M De
Original Assignee
Tibotec Pharm Ltd
Baere Inky Paul Madeleine De
Guenter Kraus
Laurence Tatiana Rimsky
Bart Anna Julien Maes
Hilde Azijn
Bethune Marie-Pierre T M M De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd, Baere Inky Paul Madeleine De, Guenter Kraus, Laurence Tatiana Rimsky, Bart Anna Julien Maes, Hilde Azijn, Bethune Marie-Pierre T M M De filed Critical Tibotec Pharm Ltd
Priority to EP07765259A priority Critical patent/EP2010680A2/en
Priority to AU2007239535A priority patent/AU2007239535B2/en
Priority to CA002646586A priority patent/CA2646586A1/en
Priority to US12/296,987 priority patent/US20100009341A1/en
Publication of WO2007118849A2 publication Critical patent/WO2007118849A2/en
Publication of WO2007118849A3 publication Critical patent/WO2007118849A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2
    • G01N2333/161—HIV-1, HIV-2 gag-pol, e.g. p55, p24/25, p17/18, p.7, p6, p66/68, p51/52, p31/34, p32, p40

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to methods and means for the evaluation of HIV treatment. In particular, molecular events at the HIV gag and protease proteins and their effect on therapeutic efficacy of drugs are determined. The methods rely on providing HIV gag and protease nucleic acid material and evaluating a treatment either through genotyping or phenotyping. Said method may find use in multiple fields including diagnostics, drug screening, pharmacogenetics and drug development.
PCT/EP2007/053613 2006-04-14 2007-04-13 Methods and means for assessing hiv gag/protease inhibitor therapy WO2007118849A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP07765259A EP2010680A2 (en) 2006-04-14 2007-04-13 Methods and means for assessing hiv gag/protease inhibitor therapy
AU2007239535A AU2007239535B2 (en) 2006-04-14 2007-04-13 Methods and means for assessing HIV gag/protease inhibitor therapy
CA002646586A CA2646586A1 (en) 2006-04-14 2007-04-13 Methods and means for assessing hiv gag/protease inhibitor therapy
US12/296,987 US20100009341A1 (en) 2006-04-14 2007-04-13 Methods and means for assessing hiv gag/protease inhibitor therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112680 2006-04-14
EP06112680.1 2006-04-14

Publications (2)

Publication Number Publication Date
WO2007118849A2 WO2007118849A2 (en) 2007-10-25
WO2007118849A3 true WO2007118849A3 (en) 2008-01-10

Family

ID=36652400

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/053613 WO2007118849A2 (en) 2006-04-14 2007-04-13 Methods and means for assessing hiv gag/protease inhibitor therapy

Country Status (5)

Country Link
US (1) US20100009341A1 (en)
EP (1) EP2010680A2 (en)
AU (1) AU2007239535B2 (en)
CA (1) CA2646586A1 (en)
WO (1) WO2007118849A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2126137B1 (en) 2007-01-23 2017-06-07 Janssen Pharmaceutica NV Method for designing a drug regime for hiv-infected patients
US20120135397A1 (en) * 2009-07-07 2012-05-31 Tan Tock Seng Hospital Human immunodeficiency virus type 1 (hiv-1) detection method and kit therefor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2869045A1 (en) * 2004-04-16 2005-10-21 Bioalliance Pharma Sa METHOD OF STUDYING THE GENETIC AND FUNCTIONAL VARIABILITY OF HIV AND KIT FOR ITS IMPLEMENTATION

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795722A (en) * 1997-03-18 1998-08-18 Visible Genetics Inc. Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample
EP0877937B1 (en) * 1996-01-26 2002-05-22 Virco N.V. Method of assessing the chemotherapy of hiv-positive patients based on the phenotypic drug sensitivity of the patient's hiv strains
US5962665A (en) * 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
GB0009374D0 (en) * 2000-04-14 2000-05-31 Glaxo Group Ltd Phenotyping assay and reagents therefor
AU2002361797A1 (en) * 2001-12-19 2003-07-09 The Regents Of The University Of California Cell lines with latent immunodeficiency virus and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2869045A1 (en) * 2004-04-16 2005-10-21 Bioalliance Pharma Sa METHOD OF STUDYING THE GENETIC AND FUNCTIONAL VARIABILITY OF HIV AND KIT FOR ITS IMPLEMENTATION

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GATANAGA H ET AL: "AMINO ACID SUBSTITUTIONS IN GAG PROTEIN AT NON-CLEAVAGE SITES ARE INDISPENSABLE FOR THE DEVELOPMENT OF A HIGH MULTITUDE OF HIV-1 RESISTANCE AGAINST PROTEASE INHIBITORS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 277, no. 8, 22 February 2002 (2002-02-22), pages 5952 - 5961, XP001121729, ISSN: 0021-9258 *
MAMMANO FABRIZIO ET AL: "Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: Phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients", JOURNAL OF VIROLOGY, vol. 72, no. 9, September 1998 (1998-09-01), pages 7632 - 7637, XP002392409, ISSN: 0022-538X *
MARTINEZ-PICADO J ET AL: "HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 CLONING VECTORS FOR ANTIRETROVIRAL RESISTANCE TESTING", JOURNAL OF CLINICAL MICROBIOLOGY, WASHINGTON, DC, US, vol. 37, no. 9, September 1999 (1999-09-01), pages 2943 - 2951, XP002933597, ISSN: 0095-1137 *
MYINT LAY ET AL: "Gag non-cleavage site mutations contribute to full recovery of viral fitness in protease inhibitor-resistant human immunodeficiency virus type 1.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 48, no. 2, February 2004 (2004-02-01), pages 444 - 452, XP002392411, ISSN: 0066-4804 *
ROBINSON LAURENCE H ET AL: "Inclusion of full length human immunodeficiency virus type 1 (HIV-1) gag sequences in viral recombinants applied to drug susceptibility phenotyping", JOURNAL OF VIROLOGICAL METHODS, vol. 104, no. 2, July 2002 (2002-07-01), pages 147 - 160, XP002392410, ISSN: 0166-0934 *

Also Published As

Publication number Publication date
EP2010680A2 (en) 2009-01-07
WO2007118849A2 (en) 2007-10-25
CA2646586A1 (en) 2007-10-25
AU2007239535A1 (en) 2007-10-25
AU2007239535B2 (en) 2012-12-20
US20100009341A1 (en) 2010-01-14

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