WO2007117494A1 - Deazapurines useful as inhibitors of janus kinases - Google Patents
Deazapurines useful as inhibitors of janus kinases Download PDFInfo
- Publication number
- WO2007117494A1 WO2007117494A1 PCT/US2007/008367 US2007008367W WO2007117494A1 WO 2007117494 A1 WO2007117494 A1 WO 2007117494A1 US 2007008367 W US2007008367 W US 2007008367W WO 2007117494 A1 WO2007117494 A1 WO 2007117494A1
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- WIPO (PCT)
- Prior art keywords
- compound according
- ring
- aliphatic
- optionally substituted
- nhc
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- 0 Cc1c[s]c(*)n1 Chemical compound Cc1c[s]c(*)n1 0.000 description 18
- YYYMYHVQBYNAKQ-UHFFFAOYSA-N Cc1cc(C(CO)NC(c2cc(-c3c(cc[nH]4)c4ncn3)c[nH]2)=O)ccc1 Chemical compound Cc1cc(C(CO)NC(c2cc(-c3c(cc[nH]4)c4ncn3)c[nH]2)=O)ccc1 YYYMYHVQBYNAKQ-UHFFFAOYSA-N 0.000 description 2
- AFPWFXFMWLQTNR-UHFFFAOYSA-N CCCN(C(CC(C)C)=O)c1nc(-c2c(ccn3)c3ncn2)c[s]1 Chemical compound CCCN(C(CC(C)C)=O)c1nc(-c2c(ccn3)c3ncn2)c[s]1 AFPWFXFMWLQTNR-UHFFFAOYSA-N 0.000 description 1
- HBWIKLFFQILCFB-UHFFFAOYSA-N OCC(c1cccc(Cl)c1)NC(C(C1)NC=C1c1c(cc[nH]2)c2ncn1)=O Chemical compound OCC(c1cccc(Cl)c1)NC(C(C1)NC=C1c1c(cc[nH]2)c2ncn1)=O HBWIKLFFQILCFB-UHFFFAOYSA-N 0.000 description 1
- ZXMBAUGMRBDLJN-UHFFFAOYSA-N OCC(c1cccc(Cl)c1)NC(c1cc(-c2c(cc[nH]3)c3ncn2)c[nH]1)=O Chemical compound OCC(c1cccc(Cl)c1)NC(c1cc(-c2c(cc[nH]3)c3ncn2)c[nH]1)=O ZXMBAUGMRBDLJN-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002648250A CA2648250A1 (en) | 2006-04-05 | 2007-04-05 | Deazapurines useful as inhibitors of janus kinases |
AU2007235487A AU2007235487A1 (en) | 2006-04-05 | 2007-04-05 | Deazapurines useful as inhibitors of janus kinases |
MX2008012860A MX2008012860A (en) | 2006-04-05 | 2007-04-05 | Deazapurines useful as inhibitors of janus kinases. |
JP2009504273A JP2009532475A (en) | 2006-04-05 | 2007-04-05 | Deazapurine useful as an inhibitor of Janus kinase |
EP07754825A EP2001884A1 (en) | 2006-04-05 | 2007-04-05 | Deazapurines useful as inhibitors of janus kinases |
IL194460A IL194460A0 (en) | 2006-04-05 | 2008-10-02 | Deazapurine derivatives and pharmaceutical compositions containing the same |
US12/245,069 US20090227607A1 (en) | 2006-04-05 | 2008-10-03 | Deazapurines useful as inhibitors of janus kinases |
ZA2008/08536A ZA200808536B (en) | 2006-04-05 | 2008-10-07 | Deazapurines useful as inhibitors of janus kinases |
NO20084652A NO20084652L (en) | 2006-04-05 | 2008-11-05 | Deazapurins useful as inhibitors of januskinases |
US13/403,169 US20120316186A1 (en) | 2006-04-05 | 2012-02-23 | Deazapurines useful as inhibitors of janus kinases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78944106P | 2006-04-05 | 2006-04-05 | |
US60/789,441 | 2006-04-05 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/245,069 Continuation US20090227607A1 (en) | 2006-04-05 | 2008-10-03 | Deazapurines useful as inhibitors of janus kinases |
US12/254,069 Continuation US7688133B2 (en) | 2008-06-12 | 2008-10-20 | Power amplifier |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007117494A1 true WO2007117494A1 (en) | 2007-10-18 |
Family
ID=38377244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/008367 WO2007117494A1 (en) | 2006-04-05 | 2007-04-05 | Deazapurines useful as inhibitors of janus kinases |
Country Status (14)
Country | Link |
---|---|
US (4) | US8741912B2 (en) |
EP (1) | EP2001884A1 (en) |
JP (2) | JP2009532475A (en) |
KR (1) | KR20090018895A (en) |
CN (1) | CN101460499A (en) |
AU (1) | AU2007235487A1 (en) |
CA (1) | CA2648250A1 (en) |
IL (1) | IL194460A0 (en) |
MX (1) | MX2008012860A (en) |
NO (1) | NO20084652L (en) |
RU (1) | RU2008143361A (en) |
SG (1) | SG170828A1 (en) |
WO (1) | WO2007117494A1 (en) |
ZA (1) | ZA200808536B (en) |
Cited By (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009114512A1 (en) * | 2008-03-11 | 2009-09-17 | Incyte Corporation | Azetidine and cyclobutane derivatives as jak inhibitors |
US7598257B2 (en) | 2005-12-13 | 2009-10-06 | Incyte Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
US20100190981A1 (en) * | 2009-01-15 | 2010-07-29 | Jiacheng Zhou | Processes for preparing jak inhibitors and related intermediate compounds |
US7767816B2 (en) | 2006-01-17 | 2010-08-03 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of janus kinases |
US7834022B2 (en) | 2007-06-13 | 2010-11-16 | Incyte Corporation | Metabolites of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
WO2010135650A1 (en) * | 2009-05-22 | 2010-11-25 | Incyte Corporation | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
WO2010144486A1 (en) * | 2009-06-08 | 2010-12-16 | Takeda Pharmaceutical Company Limited | Dihydropyrrolonaphtyridinone compounds as inhibitors of jak |
WO2011003418A1 (en) | 2009-07-08 | 2011-01-13 | Leo Pharma A/S | Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors |
WO2011076734A1 (en) * | 2009-12-21 | 2011-06-30 | Euroscreen S.A. | Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases |
WO2011112662A1 (en) * | 2010-03-10 | 2011-09-15 | Incyte Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
WO2012068440A1 (en) * | 2010-11-19 | 2012-05-24 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
US8188281B2 (en) | 2004-03-30 | 2012-05-29 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of JAK and other protein kinases |
WO2012078802A1 (en) * | 2010-12-08 | 2012-06-14 | Takeda Pharmaceutical Company Limited | PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES |
WO2012093169A1 (en) | 2011-01-07 | 2012-07-12 | Leo Pharma A/S | Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
US8247421B2 (en) | 2006-12-21 | 2012-08-21 | Vertex Pharmaceuticals Incorporated | 5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors |
WO2012127506A1 (en) | 2011-03-22 | 2012-09-27 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
US8486902B2 (en) | 2009-10-09 | 2013-07-16 | Incyte Corporation | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
US8513270B2 (en) | 2006-12-22 | 2013-08-20 | Incyte Corporation | Substituted heterocycles as Janus kinase inhibitors |
US8563541B2 (en) | 2005-09-22 | 2013-10-22 | Incyte Corporation | Azepine inhibitors of Janus kinases |
US8580803B2 (en) | 2009-12-30 | 2013-11-12 | Arqule, Inc. | Substituted pyrrolo-aminopyrimidine compounds |
WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
US8691807B2 (en) | 2011-06-20 | 2014-04-08 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors |
US8722693B2 (en) | 2007-06-13 | 2014-05-13 | Incyte Corporation | Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
US8741912B2 (en) | 2006-04-05 | 2014-06-03 | Vertex Pharmaceuticals Incorporated | Deazapurines useful as inhibitors of Janus kinases |
US8829007B2 (en) | 2009-06-17 | 2014-09-09 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
US8871774B2 (en) | 2010-12-16 | 2014-10-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
US8921376B2 (en) | 2005-05-20 | 2014-12-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
US8933085B2 (en) | 2010-11-19 | 2015-01-13 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
US8987443B2 (en) | 2013-03-06 | 2015-03-24 | Incyte Corporation | Processes and intermediates for making a JAK inhibitor |
US9051319B2 (en) | 2011-08-01 | 2015-06-09 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
US9216984B2 (en) | 2009-05-22 | 2015-12-22 | Incyte Corporation | 3-[4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane—or heptane-nitrile as JAK inhibitors |
US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
US9358229B2 (en) | 2011-08-10 | 2016-06-07 | Novartis Pharma Ag | JAK PI3K/mTOR combination therapy |
US9359358B2 (en) | 2011-08-18 | 2016-06-07 | Incyte Holdings Corporation | Cyclohexyl azetidine derivatives as JAK inhibitors |
US9487521B2 (en) | 2011-09-07 | 2016-11-08 | Incyte Holdings Corporation | Processes and intermediates for making a JAK inhibitor |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
US9593115B2 (en) | 2012-09-21 | 2017-03-14 | Advinus Therapeutics Ltd. | Substituted fused tricyclic compounds, compositions, and medicinal applications thereof |
AU2015205858B2 (en) * | 2010-03-10 | 2017-04-13 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
US9655854B2 (en) | 2013-08-07 | 2017-05-23 | Incyte Corporation | Sustained release dosage forms for a JAK1 inhibitor |
US9771361B2 (en) | 2013-11-13 | 2017-09-26 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
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US9993480B2 (en) | 2011-02-18 | 2018-06-12 | Novartis Pharma Ag | mTOR/JAK inhibitor combination therapy |
US10023569B2 (en) | 2013-11-13 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
US10166191B2 (en) | 2012-11-15 | 2019-01-01 | Incyte Corporation | Sustained-release dosage forms of ruxolitinib |
US10273233B2 (en) | 2015-05-13 | 2019-04-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
US10533004B2 (en) | 2015-05-13 | 2020-01-14 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
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US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
US10758543B2 (en) | 2010-05-21 | 2020-09-01 | Incyte Corporation | Topical formulation for a JAK inhibitor |
WO2020188015A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
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UA110324C2 (en) * | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
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CA2648250A1 (en) | 2007-10-18 |
JP2009532475A (en) | 2009-09-10 |
IL194460A0 (en) | 2009-08-03 |
KR20090018895A (en) | 2009-02-24 |
ZA200808536B (en) | 2012-07-25 |
EP2001884A1 (en) | 2008-12-17 |
US20090088445A1 (en) | 2009-04-02 |
US20140315931A1 (en) | 2014-10-23 |
CN101460499A (en) | 2009-06-17 |
US20090227607A1 (en) | 2009-09-10 |
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JP2014024869A (en) | 2014-02-06 |
RU2008143361A (en) | 2010-05-10 |
US8741912B2 (en) | 2014-06-03 |
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US20120316186A1 (en) | 2012-12-13 |
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