WO2007108002A3 - Use of digitalis-like compounds in the treatment of affective disorders - Google Patents

Use of digitalis-like compounds in the treatment of affective disorders Download PDF

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Publication number
WO2007108002A3
WO2007108002A3 PCT/IL2007/000379 IL2007000379W WO2007108002A3 WO 2007108002 A3 WO2007108002 A3 WO 2007108002A3 IL 2007000379 W IL2007000379 W IL 2007000379W WO 2007108002 A3 WO2007108002 A3 WO 2007108002A3
Authority
WO
WIPO (PCT)
Prior art keywords
digitalis
compounds
treatment
affective disorders
disorders
Prior art date
Application number
PCT/IL2007/000379
Other languages
French (fr)
Other versions
WO2007108002A2 (en
Inventor
David Lichtstein
Haim Rosen
Original Assignee
Yissum Res Dev Co
David Lichtstein
Haim Rosen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co, David Lichtstein, Haim Rosen filed Critical Yissum Res Dev Co
Priority to AT07736128T priority Critical patent/ATE488275T1/en
Priority to US12/225,468 priority patent/US20090209504A1/en
Priority to DE602007010595T priority patent/DE602007010595D1/en
Priority to EP07736128A priority patent/EP1996291B1/en
Publication of WO2007108002A2 publication Critical patent/WO2007108002A2/en
Publication of WO2007108002A3 publication Critical patent/WO2007108002A3/en
Priority to IL194275A priority patent/IL194275A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Use of digitalis-like compounds such as 19-norbufalin derivatives in the treatment of affective disorders such as anxiety, depression and bipolar disorders is disclosed.
PCT/IL2007/000379 2006-03-23 2007-03-22 Use of digitalis-like compounds in the treatment of affective disorders WO2007108002A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT07736128T ATE488275T1 (en) 2006-03-23 2007-03-22 USE OF DIGITALIS-TYPE COMPOUNDS IN THE TREATMENT OF AFFECTIVE DISORDERS
US12/225,468 US20090209504A1 (en) 2006-03-23 2007-03-22 Use of Digitalis-Like Compounds in the Treatment of Affective Disorders
DE602007010595T DE602007010595D1 (en) 2006-03-23 2007-03-22 USE OF DIGITALISIC COMPOUNDS IN THE TREATMENT OF EFFECTIVE INTERFERENCE
EP07736128A EP1996291B1 (en) 2006-03-23 2007-03-22 Use of digitalis-like compounds in the treatment of affective disorders
IL194275A IL194275A0 (en) 2006-03-23 2008-09-22 Use of digitalis-like compounds in the treatment of affective disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78478206P 2006-03-23 2006-03-23
US60/784,782 2006-03-23

Publications (2)

Publication Number Publication Date
WO2007108002A2 WO2007108002A2 (en) 2007-09-27
WO2007108002A3 true WO2007108002A3 (en) 2007-11-22

Family

ID=38080904

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/000379 WO2007108002A2 (en) 2006-03-23 2007-03-22 Use of digitalis-like compounds in the treatment of affective disorders

Country Status (5)

Country Link
US (1) US20090209504A1 (en)
EP (2) EP1996291B1 (en)
AT (1) ATE488275T1 (en)
DE (1) DE602007010595D1 (en)
WO (1) WO2007108002A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2843436A1 (en) * 2011-07-29 2013-02-07 The Regents Of The University Of California Novel 17.beta.-heteroaryl-substituted steroids as modulators of gaba a receptors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001079256A1 (en) * 2000-04-17 2001-10-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem 19-norbufalin derivatives, their preparation and pharmaceutical compositions containing them
WO2004103359A1 (en) * 2003-05-16 2004-12-02 Cephalon, Inc. Pharmaceutical combination comprising modafinil and another drug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202318A (en) * 1990-05-14 1993-04-13 Syntex (U.S.A.) Inc. Tricyclic compounds acting at serotonin receptor subtypes
US7425410B2 (en) * 2003-10-30 2008-09-16 Free State Diagnostics, Llc Methods for diagnosing a bipolar disorder and unipolar disorder
US20060135443A1 (en) * 2004-10-18 2006-06-22 Bionaut Pharmaceuticals, Inc. Use of Na*/K*-ATPase inhibitors and antagonists thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001079256A1 (en) * 2000-04-17 2001-10-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem 19-norbufalin derivatives, their preparation and pharmaceutical compositions containing them
US7087590B2 (en) * 2000-04-17 2006-08-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem 19-norbufalin derivatives, their preparation and pharmaceutical compositions containing them
WO2004103359A1 (en) * 2003-05-16 2004-12-02 Cephalon, Inc. Pharmaceutical combination comprising modafinil and another drug

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
4-(3'ALPHA15'BETA-DIHYDROXY-5'BETA-ESTRAN-17'BETA-YL)FURAN-2-METHYL ALCOHOL: AN ANTI-DIGOXIN AGENT WITH A NOVEL MECHANISM OF ACTIO, JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 49, no. 2, 26 January 2006 (2006-01-26), XP008079927, ISSN: 0022-2623 *
GOLDSTEIN ET AL: "Involvement of Na<+>, K<+>-ATPase and Endogenous Digitalis-Like Compounds in Depressive Disorders", BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 60, no. 5, 1 September 2006 (2006-09-01), pages 491 - 499, XP005627918, ISSN: 0006-3223 *

Also Published As

Publication number Publication date
EP1996291A2 (en) 2008-12-03
EP2156862A1 (en) 2010-02-24
WO2007108002A2 (en) 2007-09-27
DE602007010595D1 (en) 2010-12-30
EP1996291B1 (en) 2010-11-17
ATE488275T1 (en) 2010-12-15
US20090209504A1 (en) 2009-08-20

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