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WO2007089540A3 - Handheld raman body fluid analyzer - Google Patents

Handheld raman body fluid analyzer

Info

Publication number
WO2007089540A3
WO2007089540A3 PCT/US2007/002062 US2007002062W WO2007089540A3 WO 2007089540 A3 WO2007089540 A3 WO 2007089540A3 US 2007002062 W US2007002062 W US 2007002062W WO 2007089540 A3 WO2007089540 A3 WO 2007089540A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
body
fluid
raman
sample
data
Prior art date
Application number
PCT/US2007/002062
Other languages
French (fr)
Other versions
WO2007089540A2 (en )
Inventor
Richard H Clarke
E Edward Womble
Original Assignee
Richard H Clarke
Prescient Medical Inc
E Edward Womble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N21/658Raman scattering enhancement Raman, e.g. surface plasmons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/84Systems specially adapted for particular applications
    • G01N21/8483Investigating reagent band
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N2021/653Coherent methods [CARS]
    • G01N2021/656Raman microprobe

Abstract

Methods and apparatus for in vitro detection of an analyte in a body fluid sample using low resolution Raman spectroscopy are disclosed. The body fluid analyzer includes a disposable strip for receiving a sample of body fluid on a target region, the target region including gold sol-gel to provide surface enhanced Raman scattering. A light source irradiates the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects at least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The results of the processed data are displayed on a screen to inform a user about an analyte within the body fluid sample.
PCT/US2007/002062 2005-01-27 2007-01-24 Handheld raman body fluid analyzer WO2007089540A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11340712 US7651851B2 (en) 2005-01-27 2006-01-27 Handheld Raman body fluid analyzer
US11/340,712 2006-01-27

Publications (2)

Publication Number Publication Date
WO2007089540A2 true WO2007089540A2 (en) 2007-08-09
WO2007089540A3 true true WO2007089540A3 (en) 2007-11-15

Family

ID=38327888

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/002062 WO2007089540A3 (en) 2005-01-27 2007-01-24 Handheld raman body fluid analyzer

Country Status (2)

Country Link
US (1) US7651851B2 (en)
WO (1) WO2007089540A3 (en)

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WO2006116637A3 (en) * 2005-04-27 2007-03-01 Massachusetts Inst Technology Raman spectroscopy for non-invasive glucose measurements
WO2007014173A3 (en) * 2005-07-22 2007-06-21 Massachusetts Inst Technology Intrinsic raman spectroscopy
WO2007092173A3 (en) * 2006-02-06 2008-01-24 Prescient Medical Inc Raman spectroscopic lateral flow test strip assays
US8211048B2 (en) * 2006-02-22 2012-07-03 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits
US8133194B2 (en) 2006-02-22 2012-03-13 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits
US8677650B2 (en) * 2007-06-15 2014-03-25 Abbott Cardiovascular Systems Inc. Methods and devices for drying coated stents
US8003157B2 (en) 2007-06-15 2011-08-23 Abbott Cardiovascular Systems Inc. System and method for coating a stent
WO2009149072A3 (en) * 2008-06-03 2010-03-04 The Research Foundation Of State University Of New York At Albany Identification of body fluids using raman spectroscopy
US9877672B2 (en) 2010-01-28 2018-01-30 Ellume Pty Ltd Sampling and testing device for the human or animal body
CN101806740B (en) * 2010-04-19 2011-12-21 加拿大Bc癌研究中心 Detection method of human plasma surface enhanced raman spectroscopy by integrating main component analysis
JP5640592B2 (en) 2010-09-14 2014-12-17 セイコーエプソン株式会社 The optical device unit and the detection device
JP5545144B2 (en) 2010-09-14 2014-07-09 セイコーエプソン株式会社 The optical device unit and the detection device
CN102419320A (en) 2010-09-14 2012-04-18 精工爱普生株式会社 Detection apparatus
US9581552B2 (en) * 2011-04-06 2017-02-28 Klein Medical Limited Spectroscopic analyser
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Publication number Publication date Type
US20060240401A1 (en) 2006-10-26 application
US7651851B2 (en) 2010-01-26 grant
WO2007089540A2 (en) 2007-08-09 application

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