WO2007073303A2 - Novel benzimidazole derivatives as vanilloid receptor 1 (vrl) inhibitors - Google Patents
Novel benzimidazole derivatives as vanilloid receptor 1 (vrl) inhibitors Download PDFInfo
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- WO2007073303A2 WO2007073303A2 PCT/SE2006/001467 SE2006001467W WO2007073303A2 WO 2007073303 A2 WO2007073303 A2 WO 2007073303A2 SE 2006001467 W SE2006001467 W SE 2006001467W WO 2007073303 A2 WO2007073303 A2 WO 2007073303A2
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- ethyl
- acetamide
- benzimidazol
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- 0 *C(*)(*)NC(C[n]1c2c(*)c(*)ccc2nc1)=O Chemical compound *C(*)(*)NC(C[n]1c2c(*)c(*)ccc2nc1)=O 0.000 description 1
- FUCXOIWSEFJHCP-UHFFFAOYSA-N Nc(ccc(F)c1F)c1NCCO Chemical compound Nc(ccc(F)c1F)c1NCCO FUCXOIWSEFJHCP-UHFFFAOYSA-N 0.000 description 1
- ARCACZWMYGILNI-UHFFFAOYSA-N [O-][N+](c(c(F)c1F)ccc1F)=O Chemical compound [O-][N+](c(c(F)c1F)ccc1F)=O ARCACZWMYGILNI-UHFFFAOYSA-N 0.000 description 1
- LLGJRTUJOWVXOD-UHFFFAOYSA-N [O-][N+](c(ccc(F)c1F)c1NCCO)=O Chemical compound [O-][N+](c(ccc(F)c1F)c1NCCO)=O LLGJRTUJOWVXOD-UHFFFAOYSA-N 0.000 description 1
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- the present invention relates to new compounds, to pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
- the present invention further relates to processes for the preparation of said compounds and to new intermediates used in the preparation thereof.
- VRl vanilloid receptor 1
- VRl etal. Neuron (1998) v.21, p.531- 543).
- Expression of VRl is also regulated after peripheral nerve damage of the type that leads to neuropathic pain.
- These properties of VRl make it a highly relevant target for pain and for diseases involving inflammation.
- agonists of the VRl receptor can act as analgesics through nociceptor destruction, the use of agonists, such as capsaicin and its analogues, is limited due to their pungency, neurotoxicity and induction of hypothermia. Instead, agents that block the activity of VRl should prove more useful.
- Antagonists would maintain the analgesic properties, but avoid pungency and neurotoxicity side effects.
- Compounds with VRl inhibitor activity are believed to be of potential use for the treatment and/or prophylaxis of disorders such as pain, especially that of inflammatory or traumatic origin such as arthritis, ischaemia, cancer, fibromyalgia, low back pain and post-operative pain (Walker et al J Pharmacol Exp Ther. (2003) Jan;304(l):56-62).
- visceral pains such as chronic pelvic pain, cystitis, irritable bowel syndrome (IBS), pancreatitis and the like, as well as neuropathic pain such as sciatia, diabetic neuropathy, HTV neu- ropathy, multiple sclerosis, and the like
- neuropathic pain such as sciatia, diabetic neuropathy, HTV neu- ropathy, multiple sclerosis, and the like
- neuropathic pain such as sciatia, diabetic neuropathy, HTV neu- ropathy, multiple sclerosis, and the like
- These compounds are also believed to be potentially useful for inflammatory disorders like asthma, cough, inflammatory bowel disease (IBD) (Hwang and Oh Curr Opin Pharmacol (2002) Jun;2(3):235-42).
- VRl inhibitors are also of potential use for the treatment and/or prophylaxis of the effects of exposure to VRl activators like capsaicin or tear gas, acids or heat (Szallasi ibid).
- a further portential use relates to the treatment of tolerance to VRl activators.
- VRl inhibitors may also be useful in the treatment of interstitial cystitis and pain related to interstitial cystitis.
- VRl inhibitors may also be useful in the treatment of obesity and migraine;
- WO2006/007851 discloses the use of VRl antagonists for the treatment of obesity.
- WO2004/100865 discloses compounds exhibiting inhibitory activity at the vanilloid receptor 1 (VRl).
- the object of the present invention is to provide compounds of said kind of compounds exhibiting inhibitory activity at the vanilloid receptor 1 (VRl), which compounds exhibit not only improved potency but optimized combinations of potency and other desirable properties, in particular solubility, along with good Drug Metabolism and Pharmacokinetics (DMPK) properties.
- VRl vanilloid receptor 1
- the present invention provides compounds of formula I
- R 1 is selected from nitro, cyano, halo, and acetyl
- R 2 is selected from phenyl, heteroaryl, phenylmethyl, and phenyloxymethyl; where R 2 is optionally substituted with one or more substituents Q selected from C 1-6 alkyl, C 1-6 alkoxy, C 1-6 haloalkyl, halo, C 1-6 haloalkoxy, C 3-7 cyeloalkoxy, C 3-7 cycloalkyl, C 1 .
- R 3 is H or F;
- R 4 is methyl, methoxycarbonyl or ethyl; or R 2 and R 4 may together form a monocyclic or bicyclic ring system; and salts, solvates or solvated salts thereof.
- One embodiment of the invention relates to compounds of formula I wherein R 1 is selected from nitro, cyano, fluoro, chloro, and acetyl.
- Another embodiment of the invention relates to compounds of formula I wherein R 1 is nitro.
- a further embodiment of the invention relates to compounds of formula I wherein R 1 is cyano or halo.
- One embodiment of the invention relates to compounds of formula I wherein R 1 is cyano, chloro, or fluoro.
- Another embodiment of the invention relates to compounds of formula I wherein R 2 is selected from phenyl, pyridinyl, thienyl, phenylmethyl, and phenyloxymethyl.
- a further embodiment of the invention relates to compounds of formula I wherein R 2 is phenyl substituted with one or more substituent(s) Q with one substituent Q in para-position relative to the point of attachment.
- One embodiment of the invention relates to compounds of formula I wherein R 2 is pyridin- 3-yl substituted with one or more substituent(s) Q, wherein one substituent Q is a substituent at position 6 of the pyridine ring.
- Another embodiment of the invention relates to compounds of formula I wherein R 2 is pyridin-2-yl substituted with one or more substituent(s) Q, wherein one substituent Q is a substituent at position 5 of the pyridine ring.
- a further embodiment of the invention relates to compounds of formula I wherein R 2 is thien-2-yl substituted with one or more substituent(s) Q, wherein one substituent Q is a substituent at position 5 of the thiophene ring.
- One embodiment of the invention relates to compounds of formula I wherein R 2 is phenylmethyl.
- Another embodiment of the invention relates to compounds of formula I wherein R 2 is phenoxymethyl.
- a further embodiment of the invention relates to compounds of formula I wherein Q is selected from (l-methylprop-2-yn-l-yl)oxy, 1-methylpropyloxy, 2,2,2-trifluoro-ethoxy, 2,2,3,3-tetrafluoro-propoxy, 2,2-difluoro-ethoxy, 2-fluoro-l-fluoromethyl-ethoxy, 2- fluoroethoxy, 2-methoxy-l-methyl-ethoxy, 2-methoxy-propoxy, chloro, chloro(difluoro)methyl, cyclopentyloxy, cyclopropyl, cyclopropylmethoxy, ethoxy, ethynylphenyl, fluoro, isopropoxy, isopropyl, methoxy, methylpiperidinylox, propoxy, tert- butyl, trifluoromethoxy, and trifluoromethyl.
- One embodiment of the invention relates to compounds of formula I wherein R 2 is substituted with two substiruents Q, one of which is selected from 2-fluoro-l-fluoromethyl-eth- oxy, 2-fluoroethoxy, cyclopentyloxy, methoxy, 2-fluoro-l-fluoromethyl-ethoxy, 2-meth- oxypropyloxy, and methylpiperidinyloxy; and the other one of which is selected from chloro, fluoro, and trifluoromethyl.
- Another embodiment of the invention relates to compounds of formula I wherein R 4 is methyl.
- a further embodiment of the invention relates to compounds of formula I wherein R 2 and R 4 together form a monocyclic or bicyclic ring system.
- One embodiment of the invention relates to compounds of formula I wherein R 2 and R 4 together form a bicyclic ring system.
- Another embodiment of the invention relates to compounds of formula I wherein R 2 and R 4 together form a chromanyl group.
- a further embodiment of the invention relates to compounds of formula I wherein R 1 is selected from nitro, cyano, chloro, fluoro, and acetyl;
- R 2 is phenyl substituted with one or more substituent(s) Q selected from (l-methylprop-2- yn-l-yl)oxy, 1-methylpropyloxy, 2,2,2-trifluoro-ethoxy, 2,2,3,3-tetrafluoro-propoxy, 2,2- difluoroethoxy, 2-fluoro-l-fluoromethyl-ethoxy, 2-fluoroethoxy, 2-methoxy-l-methyl-eth- oxy, 2-methoxy-propoxy, chloro, chloro(difluoro)methyl, cyclopentyloxy, cyclopropyl, ethoxy, ethynylphenyl, fluoro, isopropyl, methylpiperidinyloxy, propoxy, tert-butyl, trifluoromethoxy, and trifluoromethyl, with one substituent Q in para-position relative to the point of attachment.
- substituent(s) Q selected from (l-methylprop-2- y
- R 1 may be selected from nitro, cyano, and fluoro; and R 2 phenyl may be substituted with one or more substituent(s) Q selected from (1-methyl- prop-2-yn-l-yl)oxy, 1-methylpropyloxy, 2,2,2-trifluoro-ethoxy, 2,2,3,3-tetrafluoro-propoxy, 2-fluoroethoxy, 2-methoxy-l-methyl-ethoxy, chloro, cyclopentyloxy, cyclopropyl, ethoxy, ethynylphenyl, fluoro, isopropyl, methylpiperidinyloxy, propoxy, tert-butyl, trifluoromethoxy, and trifluoromethyl, with one substituent Q in para-position relative to the point of attachment.
- substituent(s) Q selected from (1-methyl- prop-2-yn-l-yl)oxy, 1-methylpropyloxy, 2,2,2-trifluoro-ethoxy, 2,
- One embodiment of the invention relates to compounds of formula I wherein R 1 is selected from nitro, cyano, chloro, and fluoro;
- R 2 is pyridinyl or thienyl substituted with one or more substituent(s) Q selected from 2,2,2- trifluoro-ethoxy, 2,2,3,3-tetrafluoro-propoxy, 2,2-difluoro-ethoxy, 2-fluoro-l-fluoro- methyl-ethoxy, 2-fluoroethoxy, 2-isopropoxy, chloro, cyclopentyloxy, cyclopropylmeth- oxy, isopropoxy, tert-butyl, and trifluoromethyl.
- substituent(s) Q selected from 2,2,2- trifluoro-ethoxy, 2,2,3,3-tetrafluoro-propoxy, 2,2-difluoro-ethoxy, 2-fluoro-l-fluoro- methyl-ethoxy, 2-fluoroethoxy, 2-isopropoxy, chloro, cyclopentyloxy, cyclopropylmeth- oxy, isopropoxy, ter
- R 2 may be pyridinyl or thienyl substituted with one or more substituent(s) Q selected from 2,2,2-trifluoro-ethoxy, 2,2,3,3-tetrafluoro-propoxy, 2,2-difluoro-ethoxy, 2-isopropoxy, chloro, cyclopentyloxy, cyclopropylmethoxy, isopropoxy, tert-butyl, and trifluoroniethyl.
- substituent(s) Q selected from 2,2,2-trifluoro-ethoxy, 2,2,3,3-tetrafluoro-propoxy, 2,2-difluoro-ethoxy, 2-isopropoxy, chloro, cyclopentyloxy, cyclopropylmethoxy, isopropoxy, tert-butyl, and trifluoroniethyl.
- a yet further embodiment of the invention relates to compounds selected from the group consisting of N-[I -(6-tert-butyl-2-methoxypyridin-3 -yl)ethyl] -2-(7-cyano- 1 H-benzimidazol- 1 - yl)acetamide,
- 'C 1-3 ' means a carbon group having 1, 2 or 3 carbon atoms
- 'Ci -6 ' means a carbon group having 1, 2, 3, 4, 5 or 6 carbon atoms
- 'C 3-7 ' means a carbon group having 3, 4, 5, 6 or 7 carbon atoms
- alkyl includes both straight and branched chain alkyl groups and may be, but are not limited to methyl, ethyl, n-propyl, i- propyl, n-butyl, i-butyl, s-butyl, t-butyl, n-pentyl, i-pentyl, t-pentyl, neo-pentyl, n-hexyl or i-hexyl, t-hexyl.
- amine or “amino” refers to radicals of the general formula -NRR', wherein R and R' are independently selected from hydrogen or a hydrocarbyl radical.
- aromatic refers to hydrocarbyl radicals having one or more polyunsaturated carbon rings having aromatic character, (e.g., 4n + 2 delocalized electrons) and comprising 6 up to about 14 carbon atoms.
- aryl used alone or as suffix or prefix, refers to a hydrocarbon radical having one or more polyunsaturated carbon rings having aromatic character, (e.g., 4n + 2 delocalized electrons) and comprising 5 up to about 14 carbon atoms, wherein the radical is located on a carbon of the aromatic ring.
- cycloalkyl refers to an optionally substituted, saturated cyclic hydrocarbon ring system.
- C 3-7 cycloalkyl may be cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl.
- heterocycle or “heterocyclic” or “heterocyclic moiety” refers to ring-containing monovalent and divalent radicals having one or more heteroatoms, independently selected from N, O, P and S, as part of the ring structure and comprising at least 3 and up to about 20 atoms in the rings preferably 5 and 6 membered rings.
- Heterocyclic moieties may be saturated or unsaturated, containing one or more double bonds, and heterocyclic moieties may contain more than one ring.
- heterocycloalkyloxy denotes a 3- to 7-membered, non-aromatic, partially or completely saturated hydrocarbon group, which contains one ring and at least one het- eroatom.
- heterocycle include, but are not limited to pyrrolidinyloxy, pyr- rolidonyloxy, piperidinyloxy, piperazinyloxy, morpholinyloxy, oxazolyloxy, 2-oxazoli- donyloxy or tetrahydrofuranyloxy.
- heteroaryl refers to an optionally substituted monocyclic or bicyclic unsaturated aromatic ring system containing at least one heteroatom selected independently form N, O or S.
- heteroaryl may be, but are not limited to pyridyl, pyrrolyl, furyl, thienyl, imidazolyl, oxazolyl, isoxazolyl, thia- zolyl, pyrazolyl, benzofuryl, indolyl, isoindolyl, benzimidazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, tetrazolyl, triazolyl or oxazolyl.
- arylalkyl and “heteroarylalkyl” refer to a substituent that is attached via the alkyl group to an aryl or heteroaryl group.
- haloalkyl means an alkyl group as defined above, which is substituted with halo as defined above.
- Ci-ehaloalkyl may include, but is not limited to fluoromethyl, difluoromethyl, trifluoromethyl, fluoro- ethyl, difiuoroethyl or bromopropyl.
- the present invention relates to the compounds of the invention as hereinbefore defined as well as to the salts, solvates or solvated salts thereof.
- Salts for use in pharmaceutical compositions will be pharmaceutically acceptable salts, but other salts may be useful in the production of the compounds of the invention.
- a suitable pharmaceutically acceptable salt of the compounds of the invention is, for ex- ample, an acid-addition salt, for example an inorganic or organic acid.
- a suitable pharmaceutically acceptable salt of the compounds of the invention is an alkali metal salt, an alkaline earth metal salt or a salt with an organic base.
- Some compounds of the invention may have chiral centres and/or geometric isomeric centres (E- and Z- isomers), and it is to be understood that the invention encompasses all such optical, diastereoisomeric and geometric isomers.
- the invention also relates to any and all tautomeric forms of the compounds of the invention.
- Some compounds of the present invention may be prepared according to the methods described in PCT/SE2004/000738.
- Another aspect of the present invention provides processes for preparing compounds of formula I, or salts, solvates or solvated salts thereof.
- heterocyclic Chemistry J. A. Joule, K. Mills, G. F. Smith, 3 rd ed. Chapman and Hall (1995), p. 189-224 and "Heterocyclic Chemistry", T. L. Gilchrist, 2 nd ed. Longman Scientific and Technical (1992), p. 248-282.
- room temperature and “ambient temperature” shall mean, unless otherwise specified, a temperature between 16 and 25 °C.
- One embodiment of the invention relates to processes for the preparation of the compound of formula I according to the General Method A or Method B, wherein R 1 through R 4 , are defined as in formula I, comprising; Method A
- the target compound of formula I is obtained from the benzimidazolylacetic acid of formula II or its deprotonated form, via its conversion into an activated form, i.e. either the acyl chloride by treatment with oxalyl chloride or the mixed anhydride by treatment with ⁇ -(T-azabenzotriazoll-y ⁇ -Nj ⁇ iV' ⁇ '-tetramethyluronium hexafluorophosphate and further treatment with an appropriate amine NH 2 CHR 2 R 4 .
- This reaction may be performed in any manner known to the skilled man in the art.
- the activation may be performed using any other similar activating reagent like 1,3-dicyclohexylcarbodiimide, l-ethyl-3-(3-di- methylaminopropyl)carbodiimide hydrochloride or l,l'-carbonyldiimidazole.
- Suitable solvents to be used for this reaction may be halogenated hydrocarbons such as chloroform, dichloromethane and dichloroethane or aromatic and heteroaromatic compounds such as benzene, toluene, xylene, pyridine and lutidine or ethers such as ethyl etiher, tetrahydrofu- ran and dioxan or aprotic polar solvents like acetonitrile and dimethylformamide, or any mixtures thereof.
- halogenated hydrocarbons such as chloroform, dichloromethane and dichloroethane or aromatic and heteroaromatic compounds such as benzene, toluene, xylene, pyridine and lutidine or ethers such as ethyl etiher, tetrahydrofu- ran and dioxan or aprotic polar solvents like acetonitrile and dimethylformamide, or any mixtures thereof.
- Catalysts such as heteroaromatic bases like pyridine and lutidine or tertiary amines like triethylamine, iV-methylmorpholine and ethyl diisopropylamine may be used as well.
- the temperature may be between -30 and 5O 0 C and the reaction time between l and 30 h.
- Starting materials, the acids of formula II may be obtained using multistep procedures described in detail in the following examples of synthesis, starting from commercially available appropriately 1,2,3-trisubstituted benzenes and 1, 2,3, 4-tetrasubstituted benzenes.
- the target compound of formula Ia is obtained by two-step procedure from the benzimidazolylacetic acid of formula II or its deprotonated form.
- the first step includes conversion of acid II into intermediate III according to the procedure of Method A, while at the second step the intermediate is converted into the final product in Mitsunobu conditions using an appropriate alcohol R 5 OH.
- Another embodiment relates to the use of these compounds as intermediates in the preparation of compounds of the invention.
- a pharmaceutical composition comprising as active ingredient a therapeutically effective amount of the compound of the invention, or salts, solvates or solvated salts thereof, in association with one or more pharmaceutically acceptable diluents, excipients and/or inert carriers.
- the composition may be in a form suitable for oral administration, for example as a tablet, pill, syrup, powder, granule or capsule, for parenteral injection (including intravenous, subcutaneous, intramuscular, intravascular or infusion) as a sterile solution, suspension or emulsion, for topical administration e.g. as an ointment, patch or cream or for rectal administration e.g. as a suppository.
- parenteral injection including intravenous, subcutaneous, intramuscular, intravascular or infusion
- a sterile solution suspension or emulsion
- topical administration e.g. as an ointment, patch or cream
- rectal administration e.g. as a suppository.
- compositions may be prepared in a conventional manner using one or more conventional excipients, pharmaceutical acceptable diluents and/or inert carriers.
- Suitable daily doses of the compounds of the invention in the treatment of a mammal, in- eluding man, are approximately 0.01 to 250 mg/kg bodyweight at peroral administration and about 0.001 to 250 mg/kg bodyweight at parenteral administration.
- the typical daily dose of the active ingredient varies within a wide range and will depend on various factors such as the relevant indication, severity of the illness being treated, the route of administration, the age, weight and sex of the patient and the particular compound being used, and may be determined by a physician.
- compositions may be obtained by conventional procedures well known in the pharmaceutical art. Medical use
- the compounds according to the present invention are useful in therapy.
- the compounds may be used to produce an inhibitory effect of VRl in mammals, including man.
- VRl are highly expressed in the peripheral nervous system and in other tissues.
- the compounds of the invention are well suited for the treatment of VRl mediated disorders.
- the compounds of the invention are expected to be suitable for the treatment of acute and chronic pain, acute and chronic neuropathic pain and acute and chronic inflammatory pain.
- Examples of such disorder may be selected from the group comprising low back pain, post-operative pain, visceral pains like chronic pelvic pain and the like.
- the compounds of the invention are also expected to be suitable for the treatment of acute and chronic nociceptive pain.
- cystitis including interstitial cystitis and pain related thereto, ischeamic, sciatia, diabetic neuropathy, multiple sclerosis, arthritis, osteoarthritis, rheumatoid arthritis, fibromyalgia, pain and other signs and symptoms associated with psoriasis, pain and other signs and symptoms associated with cancer, emesis, urinary incontinence, hyperactive bladder and HIV neuropathy.
- cystitis including interstitial cystitis and pain related thereto, ischeamic, sciatia, diabetic neuropathy, multiple sclerosis, arthritis, osteoarthritis, rheumatoid arthritis, fibromyalgia, pain and other signs and symptoms associated with psoriasis, pain and other signs and symptoms associated with cancer, emesis, urinary incontinence, hyperactive bladder and HIV neuropathy.
- Additional relevant disorders may be selected from the group comprising gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and pancreatitis.
- Other relevant disorders are related to respiratory diseases and may be selected from the group comprising asthma, cough, chronic obstructive lung disease, specifically chronic obstructive pulmonary disease (COPD) and emphysema, lung fibrosis and interstitial lung disease.
- COPD chronic obstructive pulmonary disease
- emphysema lung fibrosis and interstitial lung disease.
- Yet other relevant disorders are obesity and obesity-related diseases or disorders, or migraine.
- the obesity or obesity-related diseases or disorders is selected from the following: type 1 diabetes, type 2 diabetes, impaired glucose tolerance, cardiovascular dis- ease, hypertension, insulin resistance, cancer and reproductive disorders.
- the VRl inhibitor(s) may be administrated by either an oral or inhaled route.
- the respiratory disease may be an acute and chronic illness and may be related to infection(s) and/or exposure to environmental pollution and/or irritants.
- the compounds of the invention may also be used as antitoxin to treat (over-) exposure to VRl activators like capsaicin, tear gas, acids or heat. Regarding heat, there is a potential use for VRl antagonists in (sun-) burn induced pain, or inflammatory pain resulting from bum injuries. The compounds may further be used for treatment of tolerance to VRl activators.
- One embodiment of the invention relates to the compounds of the invention as hereinbefore defined, for use as a medicament.
- Another embodiment of the invention relates to the compounds of the invention as hereinbefore defined, for use as a medicament for treatment of VRl mediated disorders.
- a further embodiment of the invention relates to the compounds of the invention as hereinbefore defined, for use as a medicament for treatment of acute and chronic pain disorders.
- Another embodiment of the invention relates to the compounds of the invention as hereinbefore defined for use as a medicament for treatment of acute and chronic nociceptive pain.
- One embodiment of the invention relates to the compounds of the invention as hereinbefore defined, for use as a medicament for treatment of low back pain, post-operative pain and visceral pains like chronic pelvic pain.
- Another embodiment of the invention relates to the compounds of the invention as hereinbefore defined, for use as a medicament for treatment of cystitis, including interstitial cystitis and pain related thereto, ischeamic, sciatia, diabetic neuropathy, multiple sclerosis, arthritis, osteoarthritis, rheumatoid arthritis, fibromyalgia, pain and other signs and symptoms associated with psoriasis, pain and other signs and symptoms associated with cancer, emesis, urinary incontinence, hyperactive bladder and HIV neuropathy.
- cystitis including interstitial cystitis and pain related thereto, ischeamic, sciatia, diabetic neuropathy, multiple sclerosis, arthritis, osteoarthritis, rheumatoid arthritis, fibromyalgia, pain and other signs and symptoms associated with psoriasis, pain and other signs and symptoms associated with cancer, emesis, urinary incontinence, hyperactive bladder and HIV neuropathy.
- a further embodiment of the invention relates to the compounds of the invention as hereinbefore defined, for use as a medicament for treatment of gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and pan- creatitis.
- GERD gastroesophageal reflux disease
- IBS irritable bowel syndrome
- IBD inflammatory bowel disease
- pan- creatitis pan- creatitis
- Yet a further embodiment of the invention relates to the compounds of the invention as hereinbefore defined, for use as a medicament for treatment of respiratory diseases selected from the group comprising asthma, cough, chronic obstructive pulmonary disease (COPD), chronic obstructive lung disease and emphysema, lung fibrosis and interstitial lung disease.
- respiratory diseases selected from the group comprising asthma, cough, chronic obstructive pulmonary disease (COPD), chronic obstructive lung disease and emphysema, lung fibrosis and interstitial lung disease.
- One embodiment of the invention relates to the use of the compound of the invention as hereinbefore defined, in the manufacture of a medicament for treatment of VRl mediated disorders and for treatment of acute and chronic pain disorders, acute and chronic neuropathic pain and acute and chronic inflammatory pain, and respiratory diseases and any other disorder mentioned above.
- Another embodiment of the invention relates to a method of treatment of VRl mediated disorders and acute and chronic pain disorders, acute and chronic neuropathic pain and acute and chronic inflammatory pain, and respiratory diseases, and any other disorder mentioned above, comprising administering to a mammal, including man in need of such treatment, a therapeutically effective amount of the compounds of the invention, as hereinbefore defined.
- a further embodiment of the invention relates to a pharmaceutical composition
- a pharmaceutical composition comprising a compound of the invention as hereinbefore defined, for use in treatment of VRl mediated disorders and for treatment of acute and chronic pain disorders, acute and chronic neuropathic pain and acute and chronic inflammatory pain, and respiratory diseases, and any other disorder mentioned above.
- the term “therapy” and “treatment” includes prevention and prophylaxis, unless there are specific indications to the contrary.
- the terms “treat”, “therapeutic” and “therapeutically” should be construed accordingly.
- inhibitor and “antagonist” mean a compound that by any means, partly or completely, blocks the transduction pathway lead- ing to the production of a response by the ligand.
- disorder means any condition and disease associated with vanilloid receptor activity.
- the compounds of the invention are also useful as pharmacological tools in the development and standardisation of in vitro and in vivo test systems for the evaluation of the effects of inhibitors of VRl related activity in laboratory animals such as cats, dogs, rabbits, monkeys, rats and mice, as part of the search for new therapeutics agents.
- laboratory animals such as cats, dogs, rabbits, monkeys, rats and mice, as part of the search for new therapeutics agents.
- a 2-[(2,3-difluoro-6-nitrophenyl)amino]ethanol A solution of l,2,3-trifluoro-4-nitro- benzene (5.0 g, 28.2 mmol) and ethanolamine (1.72 g, 28.2 mmol) in 100 ml of ethanol is stirred over night at room temperature then at 70 0 C for 5 hours. The reaction is concentrated to dryness and purified by silica gel flash chromatography using a gradient of 80/20 to 20/80 heptane/ethyl acetate providing an orange solid. Yield (3.8 g, 62 %).
- the reaction is concentrated to dryness, taken into 100 ml of 2 N NH 3 in ethanol and stirred for 2.5 hrs.
- the reaction is concentrated and taken into ethyl acetate.
- the resulting precipitate is collected by filtration and rinsed with cold ethyl acetate.
- the mother liquor is concentrated and purified by silica gel flash chromatrography using ethyl acetate/heptane. The combined yield is 3.2 g or 93 % for two steps based on 3.8 g of 2-[(2,3-difiuoro-6-nitro- phenyl)amino]ethanol.
- 2-(6,7-difluoro-lH-benzimidazol-l-yl)ethanol (2.96 g, 15 mmol) is taken into 75 ml of MeCN and sodium phosphate buffer (56 ml, 0.67 M, p ⁇ 6.8) and the mixture is heated to 42 0 C.
- Tempo 165 mg, 1.05 mol
- Tempo is added followed by the simultaneous dropwise addition of a solution OfNaClO 2 (3.38 g, 80 % pure, 30 mmol in 15 ml water) and a solution of bleach (350 ⁇ L of 6 % NaOCl in 7.5 mL water) over 1.5 hours. After 48 hrs, the same quantities OfNaClO 2 and bleach are added.
- 6-chloronicotinonitrile (0.30 g, 2.2 mmol) was a mixture of 2,2,2 -trifluoroethanol (0.19 mL, 2.6 mmol) and potassium tert-butoxide (IM solution in THF, 2.5 mL, 2.5 mmol) added at 0-5 0 C. The resulting mixture was stirred at ambient temperature for 1 hour. Water was added (20 mL) followed by extraction with ethyl acetate (2 x 20 mL). The organic layer was dried over sodium sulphate and concentrated in vacuum affording 6-(2,2,2- trifluoroethoxy)nicotinonitrile, 0.42 g (96%).
- the organic phase was separated and extracted with hydrochloric acid (5%, 20 mL).
- the aqueous phase was con- centrated to dryness in vacuum and coevaporated twice with acetonitrile to yield the title product as a salt with hydrochloric acid (0.4 g, 75%). It was converted into the neutral form of l-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl] ethanamine by extraction with chloroform from a basicified (pH 8-9) water solution.
- the title compound was synthesised according to the 2-step procedure described for the synthesis of l-[6-(2,2,2-trifiuoroethoxy)pyridin-3-yl]ethanamine starting from 6-chloroni- cotinonitrile and 2,2,3,3-tetrafluoropropan-l-ol.
- the title compound was synthesised according to the 2-step procedure described for the synthesis of l-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethanamine starting from 6-chloroni- cotinonitrile and cyclopentanol.
- A.4-[(l -Methylpiperidin-4-yl)oxy]-3-(trifluoromethyl)benzonitrile A mixture of 4-hydroxy-iV-methylpiperidine (133 mg, 1.15 mmol) and potassium tert-bu- toxide (150 mg, 1.27 mmol) in tetrahydrofuran (2.5 mL) was stirred under nitrogen for 10 min. 4-Fluoro-3-(trifluoromethyl)benzonitrile (218 mg, 1.15 mmol) was added, and the 5 reaction mixture was stirred at ambient temperature for 1 h. The solvent was removed in vacuo, and the residue was partitioned between a 1 M NaOH solution and ethyl acetate.
- the aqueous layer is extracted three times with ethyl acetate and the combined or- ganics are washed with 1 N HCl.
- the aqueous phase is separated and washed with ethyl acetate, made basic with 1 N NaOH then extracted three times with ethyl acetate.
- the combined organic layers are then dried with over MgSO 4 , filtered and concentrated. Yielded 171 mg, 42 %.
- aqueous layer is extracted three times with ethyl acetate and the combined organics are washed with 1 N HCl.
- the aqueous phase is separated and washed with ethyl acetate, made basic with 1 N NaOH then extracted three times with ethyl acetate.
- the combined organic layers are then dried with over MgSO 4 , filtered and concentrated. Syntheses of the intermediates: nicotinonitriles, 21) - 24)
- the title compound was synthesized according to the procedure described for the synthesis of 6-ter ⁇ butylnicotinonitrile starting from 2-methoxynicotinonitrile (8.02 g, 5.98 mmol), pivalic acid (3.05 g, 39.9 mmol), AgNO 3 (0.13 g, 0.78 mmol), (NBU) 2 S 2 O 8 (1.78 g, 7.78 mmol) and 6 ml 10 % H 2 SO 4 . Purified by normal phase chromatography using 95/5 to 90/10 heptane/ethyl acetate. (Yield: 80 mg, 7 %).
- the reaction is concen- trated to remove the organics and extracted 3 times with ethyl acetate.
- the combined organic layers are extracted with 1 H HCl.
- the aqueous layer is basified with 28 % NH 4 OH and extracted 3 times with ethyl acetate.
- the combined organic layers are washed with brine, dried over Na 2 SO 4 , filtered and concentrated. (Yield: 488 mg, 49 %).
- the crude material was purified by preparative HPLC on a Phenome- nex, Synersi 4 ⁇ Polar RP (or Gemini 5 ⁇ C18) column using a gradient of 0.05 % aqueous trifluoroacetic acid and acetonitrile as an eluent (or aqueous amonium bicarbonate 10 mM and acetonitrile depending on the best pH conditions for separation) .
- Example 72 N-[l-(6-tert-butyI-2-methoxypyridin-3-yl)ethyl]-2-(7-cyano-lH- benzimidazo ⁇ -l-yl)acetamide.
- Example 73 N-[l-(6-tert-butyl-2-methylpyridin-3-yl)ethyl]-2-(6,7-difluoro-lH- benzimidazol-l-yl)acetamide.
- the title compound was synthesized according to the procedure described for the synthesis of 2-methylnicotinamide, starting from [l-(6-fert-butyl-2-methylpyridin-3-yl)ethyl]amine (intermediate 32) (31.5 mg, 0.16 mmol), 6,7-diflurobenzimidazole-l -acetic acid (35 mg 0.16 mmol) HATU (38 mg, 0.18 mmol) and DIPEA (71 ⁇ l, 0.41 mmol). Water was added and the reaction concentrated. The mixture was partitioned between ethyl acetate and water, and extracted 3 more times with ethyl acetate.
- Example 74 N-[l-(6-tert-butyl-4-methylpyridin-3-yl)ethyl]-2-(7-cyano-lH- benzimidazol-l-yl)acetamide.
- the title compound was synthesized according to the procedure described for the synthesis of 2-methylnicotinamide, starting from [l-(6-tert-butyl-4-methylpyridin-3-yl)ethyl] amine (intermediate 28) (52 mg, 0.27 mmol), 7-cyanobenzimidazole-l -acetic acid (54.4 mg, 0.27 mmol), HATU (108 mg, 0.28 mmol) and DIPEA (117 ⁇ L, 2.5 mmol).
- Example 75 N-Il ⁇ -tert-butyl ⁇ -chloropyridin-S-y ⁇ ethyy ⁇ T-cyano-lH- benzimidazol-l-yl)acetamide.
- the title compound was synthesized according to the procedure described for the synthesis of 2-methylnicotinamide, starting from [l-(6 ⁇ fer ⁇ butyl ⁇ 2-chloropyridin-3-yl)ethyl]amine (intermediate 26) (100 mg, 0.47 mmol), 7-cyanobenzimidazole-l -acetic acid (0.42 mmol), HATU (191 mg, 0.5 mmol) and DIPEA (182 ⁇ L, 1.41 mmol).
- the title compound was synthesized according to the procedure described for the synthesis of 2-methylnicotinamide, starting from [l-(6-tert-butylpyridin-3-yl)ethyl]amine (intermediate 25) (93 mg, 0.52 mmol), 7-cyanobenzimidazole-l -acetic acid (100 mg, 0.5 mmol), 5 HATU (198 mg, 0.52 mmol) and DIPEA (226 ⁇ L, 1.3 mmol). Water is added and the reaction is concentrated then purified by reverse phase chromatography.
- Transfected CHO cells stably expessing hVRl (15,000 cells/well) are seeded in 50 ul media in a black clear bottom 384 plate (Greiner) and grown in a humidified incubator (37°C, 2% CO 2 ), 24-30 hours prior to experiment.
- the media is removed from the cell plate by inversion and 2 ⁇ M Fluo-4 is added using a multidrop (Labsy stems). Following the 40 minutes dye incubation in the dark at 37 0 C and 2% CO 2 , the extracellular dye present is washed away using an EMBLA (Scatron), leaving the cells in 40ul of assay buffer (1 X HBSS, 10 niM D-Glucose, 1 roM CaCl 2 , 10 mM HEPES, 10 X 7.5% NaHCO 3 and 2.5 mM Probenecid).
- assay buffer (1 X HBSS, 10 niM D-Glucose, 1 roM CaCl 2 , 10 mM HEPES, 10 X 7.5% NaHCO 3 and 2.5 mM Probenecid).
- the fluorescence is read using FLIPR filter 1 (em 520-545 nM).
- a cellular baseline recording is taken for 30 seconds, followed by a 20 ⁇ l addition of 10, titrated half-log concentrations of the test compound, yielding cellular concentration ranging from 3 ⁇ M to 0.1 nM.
- Data is collected every 2 seconds for a further 5 minutes prior to the addition of a VRl agonist solution: 20-50 nM solution of capsaicin by the FLIPR pipettor.
- the FLIPR continues to collect data for a further 4 minutes.
- Compounds having antagonistic properties against the hVRl will inhibit the increase in intracellular calcium in response to the capsaicin addition.
- hVRl FLIPR Fluorometric Image Plate Reader
- HEK T-REX hVRl inducible cells are grown in supplemented DMEM medium (10% FBS, 2 mM Glutamine, 5 ⁇ g/ml Blasticidine & 350 ⁇ g/ml Zeocin).
- HEK cells are plated in 384-black polylysine coated plate (Costar) at 10000 cells/well/50 ⁇ l for 24 hours or 5,500 cells /well 48 hours in a humidified incubator (5% CO 2 and 37 0 C) in DMEM medium without selection agent.
- HEK T-Rex hVRl cells are induced with O.l ⁇ g/ml Tetracycline 16 hours prior the experiment.
- the media is removed from the cell plate by inversion and 2 ⁇ M Fluo-4 is added using a multidrop (Labsystems). Following the 30 to 40 minutes dye incubation in the dark at 37°C and 2% CO 2 , the extracellular dye present is washed away using an Mi- croplateWasher SkatronEmbla 384, leaving the cells in 25 ⁇ l of assay buffer (IX HBSS without Ca ⁇ /Mg ⁇ /sodium bicarbonate, ImM CaCl 2 & 5 mM D-Glucose).
- assay buffer IX HBSS without Ca ⁇ /Mg ⁇ /sodium bicarbonate, ImM CaCl 2 & 5 mM D-Glucose.
- the fluorescence is read using FLIPR filter 1 (em 520-545 nM).
- a cellular baseline recording is taken for 10 seconds, followed by 12,5 ⁇ l addition of test compounds, 10 points dilution 3 fold concentration, yielding cellular concentration ranging from 22.5 ⁇ M to 0.1 nM.
- Data are collected every 2 seconds for a further 5 minutes prior to the addition of a VRl agonist solution: 20 nM (or 50 nM) capsaicin solution is added by the FLIPR pipettor.
- the FLIPR continues to collect data for a further 4 minutes.
- Compounds having antagonistic properties against the hVRl will inhibit the increase in intracellular calcium in response to the capsaicin addition.
- DRGs were dissected out from adult Sprague Dawley rats (100-300 gr), and placed on ice in Ll 5 Leibovitz medium. The ganglia were en ⁇ yme treated with Collagenase 80U/ml+ Dispase 34 U/ml dissolved in DMEM +5% serum, overnight at 37 0 C. The next day, cells were triturated with fire polished pasteur pipettes, and seeded in the center of 58 mm diameter Nunc cell dishes coated with PoIy-D Lysine (1 mg/ml).
- the DRGs were cultured in a defined medium without foetal bovine serum, containing Dulbecco's MEM / NUT MDC F-12 (1:1) without L-glutamine but with pyridoxine, 6 mg/mL D(+)-Glucose, 100 ⁇ g/mL apo-transferrin, 1 mg/mL BSA, 20 ⁇ g/mL insulin, 2 mM L-glutamine, 50 IU/ mL Penicillin, 50 ⁇ g / mL Streptomycin and 0.01 ⁇ g/mL NGF-7S. When the cells had grown for 2 days up to 4 weeks, the experiments were done. Cells were chosen based on size and presence of neurites. Small cells with long processes were used for recording (most likely to be C neurons, with native VRl receptors).
- the extracellular solution comprised (in mM): NaCl 137, KCl 5, MgCl 2 * H 2 O 1.2, HEPES 10, Glucose 10, EGTA 5, Sucrose 50, pH to 7.4 with NaOH.
- the intracellular solution comprised K-gluconate 140, NaCl 3, MgCl 2 * H 2 O 1.2, HEPES 10, EGTA 1, pH to 7.2 with KOH.
- IBD inflammatory bowel disease GERD gastro-esophageal reflux disease
- IC50 values as measured in the assays described above are 150 nM or less. In one aspect of the invention the IC50 is below 10 nM Table 3. Specimen results from the hVRl FLIPR
- the in vivo pharmacological properties of some of the compounds according to the present invention have been determined using two classical NSAID-sensitive inflammatory models, the Carrageenan model and the Freund's Complete Adjuvant (FCA) model.
- FCA algae-derived polysaccharide, type IV, lOO ⁇ l, from Sigma- Aldrich
- FCA 25 ⁇ l, from Sigma-Aldrich, (ImI of FCA contains lmg mycobacterium tuberculosis heat killed and dried, 0.85 ml mineral oil and 0.15ml mannide monooleate, cf. Nagakura et al.
- Rats Pain, 1988; 32(l):77-88). Rats are placed in individual plexiglass boxes on a glass surface, which is maintained at 3O 0 C, and a heat- source (rate of heat increase: ⁇ 1.1 °C/s) is focused onto the plantar surface of the affected paw. The time from the initiation of the heat until the animal withdraws the paw is re- corded. A decrease in Paw Withdrawal Latency (PWL) relative to na ⁇ ve animals indicates a hyperalgesic state.
- PWL Paw Withdrawal Latency
- the degree of reversal of hyperalgesia is measured by the ability of the compounds to re- 5 turn PWL to normal levels.
- Said more active enantiomers were is obtained by preparing the compounds from intermediates that had been resolved enzymati- cally and coupled to the acids to produce target compounds having ⁇ 90% enantiopurity.
- the latter were additionally purified by means of chiral chromatography.
- the PWL of each animal is measured twice, and the average of the two is taken as the response.
- the responses of all animals within a given group are then averaged, and Standard Deviation and
- rats 150-175g, Charles River, St. Constant, Canada
- groups of 7-9 were housed in groups of 7-9 in a temperature controlled room (22 ⁇ 1.5°C, 30-80% humidity,
Abstract
Description
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CA002634804A CA2634804A1 (en) | 2005-12-23 | 2006-12-21 | Novel benzimidazole derivatives as vanilloid receptor 1 (vrl) inhibitors |
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BRPI0620410-4A BRPI0620410A2 (en) | 2005-12-23 | 2006-12-21 | compound and use of compounds |
CN2006800533688A CN101389610B (en) | 2005-12-23 | 2006-12-21 | Novel benzimidazole derivatives as vanilloid receptor 1 (vrl) inhibitors |
AU2006327320A AU2006327320B2 (en) | 2005-12-23 | 2006-12-21 | Novel benzimidazole derivatives as vanilloid receptor 1 (VRL) inhibitors |
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JP2008547169A JP2009521431A (en) | 2005-12-23 | 2006-12-21 | Novel benzimidazole derivatives as vanilloid receptor 1 (VR1) inhibitors |
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EP06835882A EP1966156B1 (en) | 2005-12-23 | 2006-12-21 | New compounds iii |
IL191753A IL191753A0 (en) | 2005-12-23 | 2008-05-27 | Novel benzimidazole derivatives as vanilloid receptor 1 (vrl) inhibitors |
NO20083246A NO20083246L (en) | 2005-12-23 | 2008-07-22 | Novel benzimidazole derivatives as vanilloid receptor 1 (VRL) inhibitors |
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US10561662B2 (en) | 2014-11-20 | 2020-02-18 | Takeda Pharmaceutical Company Limited | 4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139 |
US11173161B2 (en) | 2014-11-20 | 2021-11-16 | Takeda Pharmaceutical Company Limited | 4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139 |
WO2018026371A1 (en) * | 2016-08-04 | 2018-02-08 | Sunovion Pharmaceuticals Inc. | Dual nav1.2/5ht2a inhibitors for treating cns disorders |
US11186564B2 (en) | 2016-08-04 | 2021-11-30 | Sunovion Pharmaceuticals Inc. | Dual NAV1.2/5HT2a inhibitors for treating CNS disorders |
WO2022238419A1 (en) | 2021-05-10 | 2022-11-17 | AlzeCure Pharma AB | New formulations and uses |
Also Published As
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HK1121755A1 (en) | 2009-04-30 |
CA2634804A1 (en) | 2007-06-28 |
IL191753A0 (en) | 2008-12-29 |
BRPI0620410A2 (en) | 2011-11-08 |
ES2377661T3 (en) | 2012-03-29 |
RU2008122404A (en) | 2010-01-27 |
US8168668B2 (en) | 2012-05-01 |
WO2007073303A3 (en) | 2007-08-30 |
UA96277C2 (en) | 2011-10-25 |
CN101389610B (en) | 2011-12-07 |
ECSP088584A (en) | 2008-07-30 |
JP2009521431A (en) | 2009-06-04 |
RU2427573C2 (en) | 2011-08-27 |
US20080171770A1 (en) | 2008-07-17 |
TW200736227A (en) | 2007-10-01 |
AU2006327320B2 (en) | 2009-12-10 |
EP1966156A2 (en) | 2008-09-10 |
NZ569923A (en) | 2011-04-29 |
US20100286202A1 (en) | 2010-11-11 |
ATE538101T1 (en) | 2012-01-15 |
US7618993B2 (en) | 2009-11-17 |
ZA200805162B (en) | 2009-11-25 |
AU2006327320A1 (en) | 2007-06-28 |
AR058705A1 (en) | 2008-02-20 |
NO20083246L (en) | 2008-09-11 |
CN101389610A (en) | 2009-03-18 |
EP1966156B1 (en) | 2011-12-21 |
UY30048A1 (en) | 2007-07-31 |
KR20080080212A (en) | 2008-09-02 |
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