WO2007070818A1 - Six-membered heterocycles useful as serine protease inhibitors - Google Patents
Six-membered heterocycles useful as serine protease inhibitors Download PDFInfo
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- WO2007070818A1 WO2007070818A1 PCT/US2006/061973 US2006061973W WO2007070818A1 WO 2007070818 A1 WO2007070818 A1 WO 2007070818A1 US 2006061973 W US2006061973 W US 2006061973W WO 2007070818 A1 WO2007070818 A1 WO 2007070818A1
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- 0 C*Cc1cccc(C(N(CCC2)c3c2cc(C)cc3)=O)c1 Chemical compound C*Cc1cccc(C(N(CCC2)c3c2cc(C)cc3)=O)c1 0.000 description 12
- CCVUYRSQZBNBDH-UHFFFAOYSA-N CNCc1cccc(C(N(CCC2)c3c2cncc3)=O)c1 Chemical compound CNCc1cccc(C(N(CCC2)c3c2cncc3)=O)c1 CCVUYRSQZBNBDH-UHFFFAOYSA-N 0.000 description 1
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/63—One oxygen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Definitions
- the present invention relates generally to novel six-membered heterocyclic compounds, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor XIa, factor Xa, factor IXa, factor Vila, and/or plasma kallikrein.
- it relates to compounds that are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein.
- This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
- Factor XIa is a plasma serine protease involved in the regulation of blood coagulation. While blood coagulation is essential to the regulation of an organism's hemostasis, it is also involved in many pathological conditions. In thrombosis, a blood clot, or thrombus, may form and obstruct circulation locally, causing ischemia and organ damage. Alternatively, in a process known as embolism, the clot may dislodge and subsequently become trapped in a distal vessel, where it again causes ischemia and organ damage.
- thrombotic or thromboembolic disorders Diseases arising from pathological thrombus formation are collectively referred to as thrombotic or thromboembolic disorders and include acute coronary syndrome, unstable angina, myocardial infarction, thrombosis in the cavity of the heart, ischemic stroke, deep vein thrombosis, peripheral occlusive arterial disease, transient ischemic attack, and pulmonary embolism.
- thrombosis occurs on artificial surfaces in contact with blood, including catheters and artificial heart valves. Therefore, drugs that inhibit blood coagulation, or anticoagulants, are "pivotal agents for prevention and treatment of thromboembolic disorders" (Hirsh, J. et al. Blood 2005, 105, 453-463). Thromboembolic disorders are the largest cause of mortality and disability in the industrialized world. [0004] Blood coagulation is initiated in vivo by the binding of tissue factor
- TF Factor VII
- FVIIa Factor Vila
- FIX Factor IX
- FXa Factor Xa
- the FXa that is generated catalyzes the transformation of prothrombin into small amounts of thrombin before this pathway is shut down by tissue factor pathway inhibitor (TFPI).
- TFPI tissue factor pathway inhibitor
- the process of coagulation is then further propagated via the feedback activation of Factors V, VIE and XI by catalytic amounts of thrombin.
- thrombin coverts fibrinogen to fibrin, which polymerizes to form the structural framework of a blood clot, and activates platelets, which are a key cellular component of coagulation (Hoffman, M. Blood Reviews 2003 , 17, S 1 -S5).
- Factor XIa plays a key role in propagating this amplification loop and is thus an attractive target for anti-thrombotic therapy.
- Active plasma kallikrein further activates factor XII, leading to an amplification of contact activation.
- the serine protease prolylcarboxylpeptidase can activate plasma kallikrein complexed with high molecular weight kininogen in a multiprotein complex formed on the surface of cells and matrices (Shariat-Madar et al. Blood 2006, 108, 192-199).
- Contact activation is a surface mediated process responsible in part for the regulation of thrombosis and inflammation, and is mediated, at least in part, by fibrinolytic-, complement-, kininogen/kinin-, and other humoral and cellular pathways (for review, Coleman, R.
- factor XI is down-stream from factor XIIa, combined with the identical phenotype of the XII and XI deficient mice suggest that the contact activation system could play a major role in factor XI activation in vivo.
- Factor XI is a zymogen of a trypsin-like serine protease and is present in plasma at a relatively low concentration. Proteolytic activation at an internal R369- 1370 bond yields a heavy chain (369 amino acids) and a light chain (238 amino acids). The latter contains a typical trypsin-like catalytic triad (H413, D464, and S557). Activation of factor XI by thrombin is believed to occur on negatively charged surfaces, most likely on the surface of activated platelets. Platelets contain high affinity (0.8 nM) specific sites (130-500/platelet) for activated factor XI.
- factor XIa After activation, factor XIa remains surface bound and recognizes factor IX as its normal macromolecular substrate.
- thrombin activates thrombin activated fibrinolysis inhibitor (TAFI), a plasma carboxypeptidase that cleaves C-terminal lysine and arginine residues on fibrin, reducing the ability of fibrin to enhance tissue-type plasminogen activator (tPA) dependent plasminogen activation.
- TAFI thrombin activated fibrinolysis inhibitor
- tPA tissue-type plasminogen activator
- factor XI deficiency rescues the perinatal lethal phenotype of complete protein C deficiency (Chan et al., Amer. J. Pathology 2001, 158, 469-479). Furthermore, baboon cross-reactive, function blocking antibodies to human factor XI protect against baboon arterial - venous shunt thrombosis (Gruber et al, Blood 2003, 102, 953-955). Evidence for an antithrombotic effect of small molecule inhibitors of factor XIa is also disclosed in published U.S. Patent Application US20040180855A1. Taken together, these studies suggest that targeting factor XI will reduce the propensity for thrombotic and thromboembolic diseases.
- factor XI is not required for normal homeostasis, implying a superior safety profile of the factor XI mechanism compared to competing antithrombotic mechanisms.
- hemophilia A factor Vm deficiency
- hemophilia B factor IX deficiency
- mutations of the factor XI gene causing factor XI deficiency result in only a mild to moderate bleeding diathesis characterized primarily by postoperative or posttraumatic, but rarely spontaneous hemorrhage. Postoperative bleeding occurs mostly in tissue with high concentrations of endogenous fibrinolytic activity ⁇ e.g., oral cavity, and urogenital system). The majority of the cases are fortuitously identified by preoperative prolongation of APTT (intrinsic system) without any prior bleeding history.
- factor XI activation can be determined by complex formation with either Cl inhibitor or alpha 1 antitrypsin.
- AMI acute myocardial infarction
- approximately 25% of the patients had values above the upper normal range of the complex ELISA.
- This study can be viewed as evidence that at least in a subpopulation of patients with AMI, factor XI activation contributes to thrombin formation (Minnema, M.C. et at Arte ⁇ oscler.
- Plasma kallikrein is a zymogen of a trypsin-like serine protease and is present in plasma at 35 to 50 ⁇ g/mL.
- the gene structure is similar to that of factor XI.
- the amino acid sequence of plasma kallikrein has 58% homology to factor XL
- Proteolytic activation by factor XIIa at an internal 1 389- R390 bond yields a heavy chain (371 amino acids) and a light chain (248 amino acids).
- the active site of plasma kallikrein is contained in the light chain.
- the light chain of plasma kallikrein reacts with protease inhibitors, including alpha 2 macroglobulin and Cl- inhibitor.
- HMWK high molecular weight kininogen
- WO 01/27079 There are advantages in using small organic compounds, however, in preparing pharmaceuticals, e.g., small compounds generally have better oral bioavailability and compatibility in making formulations to aid in delivery of the drug as compared with large proteins or peptides.
- Small molecule inhibitors of Factor XIa are disclosed in U.S. Patent Application Publications, e.g., US20040235847A1, US20040220206A1, US20050228000A1, US20060009455A1, and US20050282805A1.
- the present invention provides novel six-membered heterocyclic compounds, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes, especially factor XIa and/or plasma kallikrein, or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof.
- the present invention also provides processes and intermediates for making the compounds of the present invention or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof.
- the present invention also provides pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof.
- the present invention also provides a method for modulation of the coagulation cascade and/or the contact activation system comprising administering to a host in need of such treatment a therapeutically effective amount of at least one of the compounds of the present invention or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof.
- the present invention also provides a method for treating thromboembolic disorders comprising administering to a host in need of such treatment a therapeutically effective amount of at least one of the compounds of the present invention or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof.
- the present invention also provides a method for treating inflammatory diseases disorders comprising administering to a host in need of such treatment a therapeutically effective amount of at least one of the compounds of the present invention or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof.
- the present invention also provides the compounds of the present invention or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, for use in therapy.
- the present invention also provides the use of the compounds of the present invention or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, for the manufacture of a medicament for the treatment of a thromboembolic disorder.
- the present invention also provides the use of the compounds of the present invention or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, for the manufacture of a medicament for the treatment of an inflammatory disorder.
- the present invention provides, inter alia, a compound of Formula (I):
- A is C3-7 cycloalkyl substituted with 0-1 R 1 and 0-3 R 2 , C3.7 cycloalkenyl substituted with 0-1 R 1 and 0-3 R 2 , phenyl substituted with 0-1 R 1 and 0-3 R 2 , naphthyl substituted with 0-1 R 1 and 0-3 R 2 , or a 5- to 12-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O) p , wherein said heterocycle is substituted 0-1 R 1 and 0-3 R 2 ; provided that A is other than a thienyl substituted with halogen, C ⁇ _ 5 alkyl,
- the group is selected from:
- R 3 is, independently at each occurrence, phenyl substituted with 0-3 R 3a and 0-1 R 3d , naphthyl substituted with 0-3 R 3a and 0-1 R 3d , or -(CH 2 ) r 5- to 12- mcmbcrcd heterocycle comprising: carbon atoms and 1-4 hctcroatoms selected from N, O, and S(O) P , wherein said heterocycle is substituted with 0-3 R 3a and 0-1 R 3d ;
- R 3d C 2 _6 alkenyl substituted with 0-2 R 3d , C 2- 6 alkynyl substituted with 0-2 R 3d , -(CH 2 )r-C 3 .io carbocycle substituted with 0-3 R 3d , or -(CH 2 ) r -5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O) p , wherein said heterocycle is substituted with 0-3 R 3d ;
- R 3c is, independently at each occurrence, Ci _6 alkyl substituted with 0-2 R 3d , C2-6 alkenyl substituted with 0-2 R 3d , C2-6 alkynyl substituted with 0-2 R 3d , -(CH2)r-C3.i0 carbocycle substituted with 0-3 R 3d , or -(CH2) r -5- to 10-membered heterocycle comprising: carbon atom
- R 3 and R 4 groups when located on adjacent atoms, can be taken together to form a C3..10 carbocycle substituted with 0-2 R 3d or a 5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O) P , wherein said heterocycle is substituted with 0-2 R 3d ;
- R 6 is, independently at each occurrence, H, Ci_6 alkyl substituted with 0-3 R d ,
- R 7 is, independently at each occurrence, H, Ci_6 alkyl, -(CH 2 ) n -C3-io carbocycle, -(CH2)n-(5- to 10-membered heteroaryl), -C(O)R 0 , -CHO, -C(O)2R C , -S(O) 2 R 0 , -CONR 8 R 0 , -OCONHR 0 , -C(O)O-(Ci -4 alkyl)OC(O)-(Ci_ 4 alkyl), or -C(O)O-(Ci -4 alkyl)OC(0)-(C6-io aryl); wherein said alkyl, carbocycle, heteroaryl, and aryl are substituted with 0-2 R f ; wherein said heteroaryl comprises: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p;
- R 8 is, independently at each occurrence, H, C ⁇ g alkyl, -(CH2) n -phenyl, or ⁇ (CH2)n-5-to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(0) p ; wherein said alkyl, phenyl and heterocycle are optionally substituted with 0-2 R f ; alternatively, R 7 and R 8 , when attached to the same nitrogen, combine to form a 5- to 10-membered heterocycle comprising: carbon atoms and 0-3 additional heteroatoms selected from N, O, and S(O) 1 ⁇ wherein said heterocycle is substituted with 0-2 R f ;
- R 8a is, independently at each occurrence, R 7 , OH, C ⁇ g alkyl, Ci_ 4 alkoxy, (C6_io aryl)-Ci.4 alkoxy, -(CH2) n -phenyl, -(CH2)n-(5- to 10-membered heteroaryl); wherein said phenyl, aryl and heteroaryl are optionally substituted with 0-2 R f ;
- R9 is, independently at each occurrence, H, Ci_6 alkyl, or -(CH2)n-phenyl; wherein said alkyl and phenyl are optionally substituted with 0-2 R f ; alternatively, R 8 and R9, when attached to the same nitrogen, combine to form a 5- to 12-membered heterocycle comprising: carbon atoms and 0-2 additional heteroatoms selected from N, O, and S(O) 1 ), wherein said heterocycle is substituted with 0-2 R d ;
- R 11 is Ci_ 4 haloalkyl, -C(O)NR 8 R 9 , -CH 2 C(O)NR 8 R 9 , -CH 2 CH 2 C(O)NR 8 R 9 , -C(O)R a , -CH 2 C(O)R a , -CH 2 CH 2 C(O)R a , -C(0)0R a , -CH 2 C(0)0R a , -CH 2 CH
- R a is, independently at each occurrence, H, CF3, Ci_6 alkyl, -(CH2) r -C3-7 cycloalkyl, -(CH2) r -C6-io ar yl > or -(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O) p ; wherein said cycloalkyl, aryl and heterocycle groups are optionally substituted with 0-2 Rf;
- R b is, independently at each occurrence, CF3, OH, C1-4 alkoxy, Ci_6 alkyl, -(CH2)r-C3.io carbocycle substituted with 0-3 R d , or -(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O) p and substituted with 0-2 R d ;
- R c is, independently at each occurrence, CF3, Ci_6 alkyl substituted with 0-2 Rf, C3_6 cycloalkyl substituted with 0-2 Rf C6-10 aryl, 5- to 10-membered heteroaryl, (C6-10 aryl)-Ci-4 alkyl, or (5-to 10-membered heteroaryl)-Ci_4 alkyl, wherein said aryl is substituted with 0-3 R f and said heteroaryl comprises: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p and substituted with 0-3 R f ;
- RS is, independently at each occurrence, H, C 1.5 alkyl, or -(CH 2 )n-phenyl; n, at each occurrence, is selected from O, 1, 2, 3, and 4; p, at each occurrence, is selected from 0, 1, and 2; and r, at each occurrence, is selected from 0, 1, 2, 3, and 4; and s, at each occurrence, is selected from 1, 2, 3, and 4; provided that: when R 11 is -CH 2 CO 2 H, A is other than substituted piperidyl (J. Med. Chem. (1999), 42(25), 5254-5265).
- the present invention includes a compound of
- the group is selected from:
- the present invention includes a compound of
- R 4 is, independently at each occurrence, H, Me, Et, Pr, F, Cl, Br, I, OCF3,
- R 11 is Ci- 4 haloalkyl, -CH 2 C(O)NR 8 R 9 , -CH 2 CH 2 C(O)NR 8 R 9 , -CH 2 C(O)R a , -CH 2 CH 2 C(O)R a , -CH 2 C(0)0R a -CH 2 CH 2 C(O)OR a , Ci -6 alkyl substituted with 0-2 R 1 lc , C 2 _6 alkenyl substituted with 0-2 R 1 la C 2- 6 alkynyl substituted with 0-2 R 1 la , -(CH 2 VC 3 -IO carbocycle substituted with 0-3 R l lb , or -(CH 2 ) r -5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(0) p , wherein said heterocycle is substituted with 0-3 R 1 lb .
- the present invention includes a compound of
- R 1 is, independently at each occurrence, F, Cl, Br, I, OCF 3 , CF 3 , OCH 3 , CH 3 ,
- R 2 is, independently at each occurrence, F, Cl, Br, CF 3 , NO 2 , -(CH 2 ) r OR a , -(CH 2 )rSR a , -C(O)OR a , -C(O)NR 8 R 9 , -NR 8 C(O)R C , -NR 8 C(O)OR 0 , -NR 8 C(O)NR 8 R 0 , -S(O) p NR 8 R 9 , -NR 8 SO 2 Rc, -NR 7 R 8 , -S(O)Rc, -S(O) 2 R 0 , Ci_6 alkyl substituted with 0-1 R 2a , or a 5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O) P , wherein said heterocycle is substituted with 0-2 R 2b ; alternately, when R 1 and R 2 groups are substituents on adjacent
- R 3 is, independently at each occurrence, phenyl substituted with 0-2 R 3a and 0-1 R 3d , naphthyl substituted with 0-2 R 3a and 0-1 R 3d , or a 5- to 12-membered heterocycle substituted with 0-2 R 3a and 0-1 R 3d , wherein said heterocycle is selected from: thiophene, furan, thiazole, tetrazole, pyridine, pyridone, pyrimidine, pyrrole, pyrazole, indole, 2-oxindole, isoindoline, indazole, 7-azaindole, benzofuran, benzothiophene, benzimidazole, benzisoxazole, benzoxazole, quinazoline, quinoline, isoquinoline, quinoxaline, phthalazine, dihydrophthalazine, dihydroisoquinoline, dihydroquinoline, dihydroquino
- R 11 is Ci -4 haloalkyl, -CH 2 C(O)NR 8 R 9 , -CH 2 CH 2 C(O)NR 8 R 9 , -CH 2 C(O)R a , -CH 2 CH 2 C(O)R a , -CH 2 C(O)OR a , -CH 2 CH 2 C(O)OR* Ci -6 alkyl substituted with 0-2 R llc , -(CH 2 )r-C3-7 cycloalkyl substituted with 0-2 R llb , -(CH 2 ) r indanyl substituted with 0-2 R 1 lb , -(CH 2 ) r -indenyl substituted with 0-2 R 11 ⁇ , -(CH 2 ) r phenyl substituted with 0-2 Rub, -(CH 2 ) r -naphthyl substituted with 0-2 R 1 Ib 5 O r -(CH 2
- the present invention includes a compound of Formula
- A is substituted with 0-1 R 1 and 0-3 R 2 and selected from: C 3-7 cycloalkyl, phenyl, naphthyl, pyridyl, 1,2,3 ,4-tetrahydronaphthyl, pyrrolidinyl, indazolyl, indolyl, imidazolyl, furanyl, thienyl, benzimidazolyl, benzisoxazolyl, benzothiazolyl, benzothiophenyl, 3,4-methylenedioxy-phenyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, quinolinyl, isoquinolinyl, lH-4-oxo-isoquinazolinyl, 2H-l-oxo-isquinilinyl, 3H-4-oxo-quinazolinyl, 3,4-dihydro-2
- R 3 is, independently at each occurrence, phenyl substituted with 0-2 R 3a , naphthyl substituted with 0-2 R 3a , or a 5-to 12-membered heterocycle comprising: carbon atoms and 1-2 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-2 R 3a ;
- R 4 is, independently at each occurrence, H, F, Cl, Br, OMe, OH, NH 2 , NHMe, NHEt, NHPr, Me, Et, Pr, 4-(methoxycarbonylamino)phenyl, CN, CF 3 , -CH 2 OH, -(CH 2 ) 2 OH, -(CH 2 ) 3 OH, -CH 2 NH 2 , -(CH 2 ) 2 NH 2 , -(CH 2 ) 3 NH 2 , CO 2 H, -C(O)NH 2 , -C(O)NHMe, -C(O)N(Me) 2 , -CH 2 CO 2 H, -CH 2 C(O)NH 2 , -CH 2 CH 2 CO 2 H,
- R 6 is H, or Ci-4 alkyl;
- RH is Ci_4 haloalkyl, -CH 2 C(O)NR 8 R 9 , -CH 2 CH 2 C(O)NR 8 R 9 , -CH 2 C(0)R a , -CH 2 CH 2 C(O)R a , -CH 2 C(0)0R a , -CH 2 CH 2 C(O)OR a , -CH 2 OBn, -CH 2 SBn, Ci_6 alkyl substituted with 0-2 R l lc , C 2 _6 alkenyl substituted with 0-2 R lla , C 2-
- the present invention includes compounds of Formula
- A is 4-aminomethyl-cyclohexyl, 4-methylcyclohexyl, 4-methylphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 4-aminomethylphenyl, 3-carbamoylphenyl, 4-carbamoylphenyl, 3-amidinophenyl, 4-amidinophenyl, 2-fluoro-4-methylphenyl, 2,6-difluoro-4-methylphenyl, 2-fluoro-4-methoxyphenyl, 2,6-difluoro-4-methoxyphenyl, 2-fluoro-4-aminomethylphenyl, 2-fluoro-4-carbamoylphenyl, 2-chloro-4-carbamoylphenyl, 2-methoxy-4-carbamoylphenyl, 4-amino-2-fluorophenyl,
- R 3 is, independently at each occurrence, phenyl, 3-biphenyl, 4-biphenyl, 3-aminophenyl, 4-aminophenyl, 3-N,N-dimethylaminophenyl, 4-phenoxyphenyl, 4-benzyloxyphenyl, 4-(/ ⁇ butoxymethyl)-phenyl, 4-methylsulfonylphenyl,
- R 4 is, independently at each occurrence, H 5 F, Cl, Br, OMe, OH, NH2, Me, Et, Pr, CN, CF 3 , -CH 2 OH, -CH 2 NH 2 , -CO 2 H, -C(O)NH 2 , -C(O)NHMe, -C(O)N(Me) 2 , -CH 2 CO 2 H, -CH 2 C(O)NH 2 , -CH 2 CH 2 CO 2 H, -NHC(O)Me, -NHCO 2 Me, -NHC(O)NHMe, -NHC(O)N(Me) 2 , -NHCH 2 CO 2 H, or -NHSO 2 Me; and
- R 11 is methyl, n-propyl, n-butyl, neopentyl, cyclohexylmethyl, carboxymethyl, benzylaminocarbonylethyl, N-phenethylaminocarbonylethyl, N-benzyl-N-methylaminocarbonylethyl, N-[(pyridine-2-yl)methyl]aminocarbonylethyl, N-[(5-methylpyrazin-2-yl)methyl]aminoethyl, N-(thiazol-2-ylmethyl)aminocarbonylethyl,
- the present invention includes compounds of
- R 11 is methyl, n-butyl, cyclohexylmethyl, carboxymethyl, benzyl, phenethyl,
- the present invention includes a compound of Formula (T), or its stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, within the scope of the first aspect wherein: A is aminomethylcyclohexyl;
- R 3 is phenyl, 4-methoxycarbonylaminophenyl, 2-amino-pyrid-4yl, or 4-hy droxy-2-oxo- 1 ,2-dihydro-quinolin-6-yl;
- R 4 is H; and
- R 11 is benzyl.
- the present invention provides a compound selected from the exemplified examples or stereoisomers or pharmaceutically acceptable salts, solvates, or prodrugs thereof.
- the present invention provides, inter alia, compounds of Formula (II):
- A is C3.7 cycloalkyl substituted with 0-1 R 1 and 0-3 R 2 , C ⁇ ,- ⁇ cycloalkenyl substituted with 0-1 R 1 and 0-3 R 2 , phenyl substituted with 0-1 R 1 and 0-3 R 2 , naphthyl substituted with 0-1 R 1 and 0-3 R 2 , or a 5- to 12-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O) p , wherein said heterocycle is substituted 0-1 R 1 and 0-3 R 2 ; provided that A is other than a thienyl substituted with halogen, C ⁇ _g alkyl, C2.6 alkenyl, or C2.6 alkynyl;
- the group is selected from:
- Z is -CH(R 11 )- or NR 12 ;
- L is -C(O)NR 10 -, -NR 10 C(O)-, -CH 2 C(O)NR 10 -, -CH 2 NR 10 C(O)-, -C(O)NR 10 CH 2 -, or -NR 10 C(O)CH 2 -;
- R 3 is, independently at each occurrence, phenyl substituted with 0-3 R 3a and 0-1 R 3d , naphthyl substituted with 0-3 R 3a and 0-1 R 3d , or -(CH 2 ) r -5- to 12- membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 R 3a and 0-1 R 3d ;
- R 3b is, independently at each occurrence, H, C ⁇ . ⁇ alkyl substituted with 0-2 R 3d , C 2 _6 alkenyl substituted with 0-2 R 3d , C 2 _6 alkynyl substituted with 0-2 R 3d ,
- R 3c is, independently at each occurrence, Ci_6 alkyl substituted with 0-2 R 3d , C 2- 6 alkenyl substituted with 0-2 R 3d , C 2 -6 alkynyl substituted with 0-2 R 3d , -(CH 2 ) r -
- Ci-6 alkyl C 2- 6 alkenyl, C 2- 6 alkynyl, C3-6 cycloalkyl, C1-4 haloalkyl, or
- Ci_4 haloalkyloxy when located on adjacent atoms, can be taken together to form a C3-10 carbocycle substituted with 0-2 R 3d or a 5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and
- R 6 is, independently at each occurrence, H, Ci_6 alkyl substituted with 0-3 R d ,
- R 7 is, independently at each occurrence, H, Ci_6 alkyl, -(CH2)n-C3-io carbocycle, -(CH2)n-(5- to 10-membered heteroaryl), -C(O)R 0 , -CHO, -C(O) 2 R 0 , -S(O) 2 R 0 , -CONR 8 R 0 , -OCONHR 0 , -C(O)O-(CM alkyl)0C(0)-(Ci_4 alkyl), or -C(O)O-(Ci-4 alkyl)OC(0)-(C6-io aryl); wherein said alkyl, carbocycle, heteroaryl, and aryl are substituted with 0-2 R f ; wherein said heteroaryl comprises: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p;
- R 8 is, independently at each occurrence, H, C ⁇ .g alkyl, -(CH2Vphenyl, or -(CH 2 )n-5-to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p; wherein said alkyl, phenyl and heterocycle are optionally substituted with 0-2 R f ; alternatively, R 7 and R 8 , when attached to the same nitrogen, combine to form a 5- to 10-membered heterocycle comprising: carbon atoms and 0-3 additional heteroatoms selected from N, O, and S(O)p 5 wherein said heterocycle is substituted with 0-2 R f ; R 8a is, independently at each occurrence, R 7 , OH, C ⁇ g alkyl, Ci_4 alkoxy,
- R 9 is, independently at each occurrence, H, Ci.6 alkyl, or -(CH 2 )rrphenyl; wherein said alkyl and phenyl are optionally substituted with 0-2 R f ; alternatively, R 8 and R 9 , when attached to the same nitrogen, combine to form a 5- to 12-membered heterocycle comprising: carbon atoms and 0-2 additional heteroatoms selected from N, O, and S(O)p ; wherein said heterocycle is substituted with 0-2 R d ;
- R 10 is, independently at each occurrence, H, Ci_6 alkyl substituted with 0-2 R 1Oa , C 2- 6 alkenyl substituted with 0-3 R 1Oa , C2-6 alkynyl substituted with 0-3 R 1Oa , -(CH 2 )r-C3_io carbocycle substituted with 0-3 R d , or -(CH 2 ) r -5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(0) p , wherein said heterocycle is substituted with 0-3 R d ;
- R 11 is Ci -4 haloalkyl, -C(O)NR 8 R 9 , -CH 2 C(O)NR 8 R 9 , -CH 2 CH 2 C(O)NR 8 R 9 , -C(O)R a , -CH 2 C(O)R a , -CH 2 CH 2 C(O)R a , -C(O)OR a , -CH 2 C(O)OR a , -CH 2 CH 2 C(O)OR a , Ci-6 alkyl substituted with 0-3 R 1 Ic 5 c 2- 6 alkenyl substituted with 0-3 R 1 la ; C 2 _6 alkynyl substituted with 0-3 R 1 la -(CH 2 ) S -C3_7 cycloalkyl substituted with 0-2 R l lb , -(CH 2 ) s -phenyl substituted with 0-3 R l lb , -(CH 2
- R 12 is Ci-6 alkyl, -(CH 2 ) s -cycloalkyl, ⁇ (CH 2 ) s -phenyl, -(CH 2 ) s -naphthyl, -(CH 2 )rNR 8 C(O)R a , -C(O)R 0 , -C(O)ORc, -CONR 8 R 0 , -S(O) 2 R 0 ,
- R a is, independently at each occurrence, H, CF3, Ci_6 alkyl, -(CH 2 ) r -C3-7 cycloalkyl, -(CH 2 ) r -C6-io aryl, or -(CH 2 )r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(0) p ; wherein said cycloalkyl
- R c is, independently at each occurrence, CF3, Ci_6 alkyl substituted with 0-2 R f , C3-6 cycloalkyl substituted with 0-2 R f , C6-10 aryl, 5- to 10-membered heteroaryl, (C6-10 aryl)-Ci_4 alkyl, or (5-to 10-membered heteroaryl)-Ci_4 alkyl, wherein said aryl is substituted with 0-3 R f and said heteroaryl comprises: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p and substituted with 0-3 R f ;
- Rg is, independently at each occurrence, H, C 1 ⁇ alkyl, or -(CH 2 ) n -phenyl; n, at each occurrence, is selected from O, 1, 2, 3, and 4; p, at each occurrence, is selected from O, 1, and 2; and r, at each occurrence, is selected from O, 1, 2, 3, and 4; and s, at each occurrence, is selected from 1, 2, 3, and 4; provided that: when R 11 is -CH 2 CO 2 H, A is other than substituted piperidyl. (J. Med. Chem. (1999), 42(25), 5254-5265)
- the present invention includes a compound of
- the group is selected from:
- the group is selected from:
- the group is selected from:
- the group is selected from:
- the group is selected from:
- the group is selected from:
- the group is selected from:
- the group is
- the group is selected from:
- A is substituted with 0-1 R 1 and 0-3 R 2 and selected from: C3_ ⁇ cycloalkyl, phenyl, naphthyl, pyridyl, 1,2,3,4-tetrahydronaphthyl, pyrrolidinyl, indazolyl, indolyl, imidazolyl, furanyl, thienyl, benzimidazolyl, benzisoxazolyl, benzothiazolyl, benzothiophenyl, 3,4-methylenedioxy-phenyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, quinolinyl, isoquinolinyl, lH-4-oxo-isoquinazolinyl, 2H- 1-oxo-isquinilinyl, 3H-4-oxo-
- A is substituted with 0-1 R 1 and 0-3 R 2 and selected from: C3-7 cycloalkyl, phenyl, pyridyl, pyrrolidinyl, indazolyl, indolyl, imidazolyl, furanyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, and pyrazolyl.
- A is substituted with 0-1 R 1 and 0-3 R 2 and selected from: naphthyl, 1,2,3,4-tetrahydronaphthyl, benzimidazolyl, benzisoxazolyl, benzothiazolyl, benzothiophenyl, 3,4-methylenedioxy-phenyl, quinolinyl, isoquinolinyl, lH-4-oxo-isoquinazolinyl, 2H- 1-oxo-isquinilinyl, 3 H-4-oxo-quinazolinyl, 3 ,4-dihydro-2H- 1 -oxo-isoquinolinyl, 2,3-dihydro-isoindolinyl, 5,6,7,8-tetrahydroquinolinyl, 1,2,3,4-tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinolinyl, and selected from: naphthyl
- A is 4-aminomethyl-cyclohexyl
- A is 4-aminomethyl-cyclohexyl
- A is indol-5-yl, indol-6-yl, indazol-6-yl,
- R 1 is, independently at each occurrence, F, Cl,
- R 2 is, independently at each occurrence, F 5 Cl,
- -C(O)NR 8 R ⁇ -NHC(O)R 0 , -CH 2 NHC(O)R C , -NHC(O)OR C , -CH 2 NHC(O)OR C 3 -NHC(O)NHR 0 , -CH 2 NHC(O)NHRc, or a 5-7 membered heterocycle substituted with 0-2 R 2b and selected from: pyrrolidinyl, 2-oxo-l-pyrrolidinyl, piperidinyl, pyrazolyl, triazolyl, or tetrazolyl.
- R 3 is, independently at each occurrence, phenyl substituted with 0-2 R 3a and 0-1 R 3d , naphthyl substituted with 0-2 R 3a and O- 1 R 3d , or a 5- to 12-membered heterocycle substituted with 0-2 R 3a and 0-1 R 3d , wherein said heterocycle is selected from: thiophene, furan, thiazole, tetrazole, pyridine, pyridone, pyrimidine, pyrrole, pyrazole, indole, 2-oxindole, isoindoline, indazole, 7-azaindole, benzofuran, benzothiophene, benzimidazole, benzisoxazole, benzoxazole, quinazoline, quinoline, isoquinoline, quinoxaline, phthalazine, dihydrophthalazine, dihydroisoquinoline, dihydro
- R 3 is, independently at each occurrence, phenyl, 3-biphenyl, 4-biphenyl, 3-aminophenyl, 4-aminophenyl, 3-N,N-dimethylaminophenyl, 4-phenoxyphenyl, 4-benzyloxyphenyl, 4-(/-butoxymethyl)-phenyl, 4-methylsulfonylphenyl, 3-cyanophenyl, 4-cyanophenyl, 3 -fluorophenyl, 4-fhiorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3-bromophenyl, 4-bromophenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 3-carboxyphenyl, 4-carboxyphenyl, 4-carboxyphenyl,
- 3-methoxycarbonylphenyl 4- methoxycarbonylphenyl, 3-carboxymethylphenyl, 4-carboxymethylphenyl, 4-methoxycarbonylmethylphenyl, 3 -ethoxycarbonylmethylphenyl, 4-ethoxycarbonylmethylphenyl, 4-ethoxycarbonylethylphenyl, 3-carbamoylphenyl, 4-carbamoylphenyl, 3-aminocarbonylmethylphenyl, 4-aminocarbonylmethylphenyl,
- R 3 is, independently at each occurrence
- R 4 is, independently at each occurrence, H, Me, Et, Pr, F, Cl, Br, I, OCF 3 , CF 3 , CN, NO 2 , -(CH 2 ) r OH, -(CH 2 )rC(O)OR a 5 0R a , SR a , -C(O)R a , -C(O)OR a , -NR7RS, -(CH 2 ) r NH 2 , -NR s (CH 2 ) r C(O)OR a -(CH 2 )rC(O)NR 8 R 9 , -NR 8 C(O)R C , -NR 8 C(O)OR 0 , -NR 8 C(O)NR 8 R 9 , -S(O)pNR 8 R 9 , -NR 8 S(O) P R C , -S(O)pR c or phenyl subsitute
- R 4 is, independently at each occurrence, H, F,
- R 4 is, independently at each occurrence, H, F,
- R 11 is C1-4 haloalkyl, -CH 2 C(O)NR 8 R 9 ,
- R 1 * is -(CH 2 )r-C3-io carbocycle substituted with 0-3 R l lb , or -(CH 2 ) r -5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 R 1 lb .
- R 1 1 is C 1-4 haloalkyl, -CH 2 C(O)NR 8 R 9 ,
- R 1 * is -(CH 2 )r-C3-7 cycloalkyl substituted with 0-2 R 1 lb , -(CH 2 ) r -indanyl substituted with 0-2 R 1 lb , -(CH 2 ) r indenyl substituted with 0-2 R l lb , -(CH 2 )r-phenyl substituted with 0-2 R llb , -(CH 2 )r-naphthyl substituted with 0-2 R l lb , or -(CH 2 ) r -5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O) p , wherein said heterocycle is substituted with 0-2 R l lb .
- R 11 is CM haloalkyl, -CH 2 C(O)NR 8 R 9 ,
- R 11 is -CH 2 OBn, -CH 2 SBn, -(CH 2 ) r C 3 . 7 cycloalkyl substituted with 0-2 R llb , -(CH 2 ) r -phenyl substituted with 0-2 R l lb , -(CH 2 )r-mdanyl substituted with 0-2 R llb , -(CH 2 ) r -indenyl substituted with 0-2 R llb , -(CH 2 )r-naphthyl substituted with 0-2 R l lb , or -(CH 2 )r ⁇ 5- to 10-membered heteroaryl substituted with 0-2 R llb and selected from thiazolyl, oxazolyl, pyrazolyl, triazolyl, tetrazolyl, thiadiazolyl, isoxazolyl, imidazolyl, pyr
- R 11 is methyl, n-butyl, cyclohexylmethyl, carboxymethyl, benzyl, phenethyl, 2-fluorobenzyl, 3-fluorobenzyl, 4-fluorpbenzyl, 2-chlorobenzyl, 3-chlorobenzyl, 4-chlorobenzyl, 3-carboxybenzyl, 3 -carbamoylbenzyl, 3 -(N-methylcarbamoyl)-benzyl, 3 -(N,N-dimethylcarbamoyl)-benzyl, 3 -(N-ethylcarbamoyl)-benzyl, 3-methylbenzyl, 4-methylbenzyl, 3-methoxybenzyl, 3-difluoromethoxybenzyl, 3 -trifluoromethoxy-benzyl, 3 -methoxycarbonylbenzyl, 3 -methylcarbonylamino-benzyl, 3 -
- R 1 * is cyclohexylmethyl, benzyl, phenethyl,
- the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and at least one of the compounds of the present invention or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof.
- the present invention provides a novel pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof.
- the present invention provides a novel process for making a compound of the present invention or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof.
- the present invention provides a novel intermediate for making a compound of the present invention or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof.
- the present invention provides a pharmaceutical composition further comprising additional therapeutic agent(s) selected from potassium channel openers, potassium channel blockers, calcium channel blockers, sodium hydrogen exchanger inhibitors, antiarrhythmic agents, antiatherosclerotic agents, anticoagulants, antithrombotic agents, prothrombolytic agents, fibrinogen antagonists, diuretics, antihypertensive agents, ATPase inhibitors, mineralocorticoid receptor antagonists, phospodiesterase inhibitors, antidiabetic agents, anti-inflammatory agents, antioxidants, angiogenesis modulators, antiosteoporosis agents, hormone replacement therapies, hormone receptor modulators, oral contraceptives, antiobesity agents, antidepressants, antianxiety agents, antipsychotic agents, antiproliferative agents, antitumor agents, antiulcer and gastroesophageal reflux disease agents, growth hormone agents and/or growth hormone secretagogues, thyroid mimetics, anti-infective agents, antiviral agents, antibacterial agents,
- the present invention provides a pharmaceutical composition further comprising additional therapeutic agent(s) selected from an anti-arrhythmic agent, an anti-hypertensive agent, an anti-coagulant agent, an anti-platelet agent, a thrombin inhibiting agent, a thrombolytic agent, a fibrinolytic agent, a calcium channel blocker, a potassium channel blocker, a cholesterol/lipid lowering agent, or a combination thereof.
- additional therapeutic agent(s) selected from an anti-arrhythmic agent, an anti-hypertensive agent, an anti-coagulant agent, an anti-platelet agent, a thrombin inhibiting agent, a thrombolytic agent, a fibrinolytic agent, a calcium channel blocker, a potassium channel blocker, a cholesterol/lipid lowering agent, or a combination thereof.
- the present invention provides a pharmaceutical composition further comprising additional therapeutic agent(s) selected from warfarin, unfractionated heparin, low molecular weight heparin, synthetic pentasaccharide, hirudin, argatroban, aspirin, ibuprofen, naproxen, sulindac, indomethacin, mefenamate, dipyridamol, droxicam, diclofenac, sulfinpyrazone, piroxicam, ticlopidine, clopidogrel, tirofiban, eptifibatide, abciximab, melagatran, ximelagatran, disulfatohirudin, tissue plasminogen activator, modified tissue plasminogen activator, anistreplase, urokinase, and streptokinase, or a combination thereof.
- additional therapeutic agent(s) selected from warfarin, unfractionated heparin, low molecular weight heparin
- the present invention provides a pharmaceutical composition wherein the additional therapeutic agent is an antihypertensive agent selected from ACE inhibitors, AT-I receptor antagonists, beta- adrenergic receptor antagonists, ETA receptor antagonists, dual ETA/AT- 1 receptor antagonists, and vasopepsidase inhibitors, an antiarrythmic agent selected from IKur inhibitors, an anticoagulant selected from thrombin inhibitors, antithrombin-i ⁇ activators, heparin co-factor II activators, other factor XIa inhibitors, other kallikrein inhibitors, plasminogen activator inhibitor (PAI-I) antagonists, thrombin activatable fibrinolysis inhibitor (TAFI) inhibitors, factor Vila inhibitors, factor IXa inhibitors, and factor Xa inhibitors, or an antiplatelet agent selected from GPIIb/ ⁇ ia blockers, protease activated receptor (PAR-I) antagonists, phosphodiesterase-III inhibitor
- an antiarrythmic agent
- the present invention provides pharmaceutical composition, wherein the additional therapeutic agent(s) are an antiplatelet agent or a combination thereof.
- the present invention provides a pharmaceutical composition, wherein the additional therapeutic agent is the antiplatelet agent clopidogrel.
- the present invention provides a method for modulation of the coagulation cascade and/or contact activation system comprising administering to a patient in need of such treatment a therapeutically effective amount of at least one of the compounds of the present invention or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof.
- the present invention provides a novel method for treating thrombotic or thromboembolic disorders comprising: administering to a patient in need of such treatment a therapeutically effective amount of at least one of the compounds of the present invention or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof.
- the present invention provides a novel method, wherein the thromboembolic disorder is selected from the group consisting of arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, arterial cerebrovascular thromboembolic disorders, and venous cerebrovascular thromboembolic disorders.
- the present invention provides a novel method, wherein the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, atrial fibrillation, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from medical implants, devices, or procedures in which blood is exposed to an artificial surface that promotes thrombosis.
- the thromboembolic disorder is selected from unstable angina, an acute coronary syndrome, atrial fibrillation, first myocardial infarction, recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral
- the present invention provides a method for treating inflammatory disorders comprising: administering to a patient in need of such treatment a therapeutically effective amount of at least one of the compounds of the present invention or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof.
- the present invention provides a method, wherein the inflammatory disorder is selected from the group consisting of sepsis, acute respiratory distress syndrome, and systemic inflammatory response syndrome.
- the present invention provides a novel method of treating a patient in need of thromboembolic disorder treatment, comprising: administering a compound of the present invention or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug form thereof in an amount effective to treat a thrombotic or thromboembolic disorder.
- the present invention provides a novel article of manufacture, comprising: (a) a first container; (b) a pharmaceutical composition located within the first container, wherein the composition, comprises: a first therapeutic agent, comprising: a compound of the present invention; and (c) a package insert stating that the pharmaceutical composition can be used for the treatment of a thromboembolic and/or inflammatory disorder.
- the present invention provides a novel article of manufacture, further comprising: (d) a second container; wherein components (a) and (b) are located within the second container and component (c) is located within or outside of the second container.
- the present invention provides a novel article of manufacture, comprising: (a) a first container; (b) a pharmaceutical composition located within the first container, wherein the composition, comprises: a first therapeutic agent, comprising: a compound of the present invention; and (c) a package insert stating that the pharmaceutical composition can be used in combination with a second therapeutic agent to treat a thromboembolic and/or inflammatory disorder.
- the present invention provides a novel article of manufacture, further comprising: (d) a second container; wherein components (a) and (b) are located within the second container and component (c) is located within or outside of the second container.
- the present invention provides a novel method, comprising: administering a compound of the present invention or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug form thereof in an amount effective to treat a thromboembolic and/or inflammatory disorder.
- the present invention provides a compound of the present invention for use in therapy.
- the present invention provides a compound of the present invention for use in therapy for treating a thromboembolic and/or inflammatory disorder.
- the present invention also provides the use of a compound of the present invention for the manufacture of a medicament for the treatment of a thromboembolic and/or inflammatory disorder.
- the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. This invention encompasses all combinations of preferred aspects of the invention noted herein. It is understood that any and all embodiments of the present invention may be taken in conjunction with any other embodiment or embodiments to describe additional more preferred embodiments. It is also to be understood that each individual element of the preferred embodiments is its own independent preferred embodiment. Furthermore, any element of an embodiment is meant to be combined with any and all other elements from any embodiment to describe an additional embodiment.
- enantiomeric or diastereomeric products When enantiomeric or diastereomeric products are prepared, they can be separated by conventional methods, for example, by chromatography or fractional crystallization.
- Compounds of the present invention, and salts thereof may exist in multiple tautomeric forms, in which hydrogen atoms are transposed to other parts of the molecules and the chemical bonds between the atoms of the molecules are consequently rearranged. It should be understood that all tautomeric forms, insofar as they may exist, are included within the invention.
- the inventive compounds may be in the free or hydrate form.
- the molecular weight of compounds of the present invention is less than about 500, 550, 600, 650, 700, 750, or 800 grams per mole.
- the molecular weight is less than about 800 grams per mole. More preferably, the molecular weight is less than about 750 grams per mole. Even more preferably, the molecular weight is less than about 700 grams per mole.
- the term "alkyl” or “alkylene” is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms.
- Ci_io alkyl (or alkylene), is intended to include Ci, Ci, C3, C4, C5, Ce, Cj, Cs, C9, and Cio alkyl groups.
- C1-C6 alkyl denotes alkyl having 1 to 6 carbon atoms. Alkyl groups can be unsubstituted or substituted so that one or more of its hydrogens are replaced by another chemical group.
- Example alkyl groups include, but are not limited to, methyl (Me), ethyl (Et), propyl ⁇ e.g., n-propyl and isopropyl), butyl (e.g., n-butyl, isobutyl, t-butyl), pentyl (e.g., n-pentyl, isopentyl, neopentyl), and the like.
- Alkenyl or “alkenylene” is intended to include hydrocarbon chains of either straight or branched configuration and having one or more double carbon- carbon bonds that may occur in any stable point along the chain.
- C2-6 alkenyl (or alkenylene), is intended to include C2, C3, C4, C5, and C6 alkenyl groups.
- alkenyl include, but are not limited to, ethenyl, 1-propenyl, 2-propenyl, 2-butenyl, 3-butenyl, 2-pentenyl, 3, pentenyl, 4-pentenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 2-methyl-2-propenyl, 4-methy 1-3 -pentenyl, and the like.
- Alkynyl or “alkynylene” is intended to include hydrocarbon chains of either straight or branched configuration and having one or more triple carbon-carbon bonds that may occur in any stable point along the chain.
- C2-6 alkynyl (or alkynylene), is intended to include C2, C3, C4, C5, and Ce alkynyl groups; such as ethynyl, propynyl, butynyl, pentynyl, hexynyl and the like.
- alkoxy or “alkyloxy” refers to an -O-alkyl group.
- Ci_6 alkoxy (or alkyloxy), is intended to include Ci, C2, C3, C4, C5, and C ⁇ alkoxy groups.
- Example alkoxy groups include, but are not limited to, methoxy, ethoxy, propoxy (e.g., n-propoxy and isopropoxy), and t-butoxy, and the like.
- alkylthio or “thioalkoxy” represents an alkyl group as defined above with the indicated number of carbon atoms attached through a sulphur bridge; for example methyl-S-, ethyl-S-, and the like.
- Halo or "halogen” includes fluoro, chloro, bromo, and iodo.
- Haloalkyl is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms, substituted with 1 or more halogen.
- haloalkyl include, but are not limited to, fluoromethyl, difluoromethyl, trifluoromethyl, trichloromethyl, pentafluoroethyl, pentachloroethyl, 2,2,2-trifluoroethyl, heptafluoropropyl, and heptachloropropyl.
- haloalkyl also include “fluoroalkyl” which is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms, substituted with 1 or more fluorine atoms.
- fluoroalkyl or “haloalkyloxy” represents a haloalkyl group as defined above with the indicated number of carbon atoms attached through an oxygen bridge.
- Ci_6 haloalkoxy is intended to include Ci, C2, C3, C4, C5, and C(, haloalkoxy groups.
- haloalkoxy examples include, but are not limited to, trifluoromethoxy, 2,2,2-trifluoroethoxy, pentafluorothoxy, and the like.
- haloalkylthio or “thiohaloalkoxy” represents a haloalkyl group as defined above with the indicated number of carbon atoms attached through a sulphur bridge; for example trifluoromethyl-S-, pentafluoroethyl-S-, and the like.
- cycloalkyl refers to cyclized alkyl groups, including mono-, bi- or poly-cyclic ring systems.
- cycloalkyl groups include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, norbornyl, and the like.
- “carbocycle” or “carbocyclic residue” is intended to mean any stable 3, 4, 5, 6, or 7-membered monocyclic or bicyclic or 7, 8, 9, 10, 11, 12, or 13-membered bicyclic or tricyclic ring, any of which may be saturated, partially unsaturated, unsaturated or aromatic.
- carbocycles include, but are not limited to, cyclopropyl, cyclobutyl, cyclobutenyl, cyclopentyl, cyclopentenyl, cyclohexyl, cycloheptenyl, cycloheptyl, cycloheptenyl, adamantyl, cyclooctyl, cyclooctenyl, cyclooctadienyl, [3.3.0]bicyclooctane, [4.3.0]bicyclononane,
- bridged rings are also included in the definition of carbocycle (e.g., [2.2.2]bicyclooctane).
- Preferred carbocycles are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, and indanyl.
- carbocycle unless otherwise specified, are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, and indanyl.
- a bridged ring occurs when one or more carbon atoms link two non-adjacent carbon atoms.
- Preferred bridges are one or two carbon atoms. It is noted that a bridge always converts a monocyclic ring into a tricyclic ring. When a ring is bridged, the substituents recited for the ring may also be present on the bridge.
- Aryl refer to monocyclic or polycyclic aromatic hydrocarbons, including, for example, phenyl, naphthyl, phenanthranyl, and the like. Aryl moieties are well known and described, for example, in Hawley's Condensed Chemical Dictionary (13 ed.), RJ. Lewis, ed., J.
- aryl may be unsubstituted or substituted with 0 to 3 groups selected from H, OH, OCH3, Cl, F, Br,
- heterocycle or “heterocyclic group” is intended to mean a stable 5, 6, or 7- membered monocyclic or bicyclic or 7, 8, 9, 10,
- I 1, 12, 13, or 14-membered bicyclic heterocyclic ring which is saturated, partially unsaturated or fully unsaturated, and which consists of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from N, O and S; and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring.
- the nitrogen and sulfur heteroatoms may optionally be oxidized (i.e., N ⁇ O and
- the nitrogen atom may be substituted or unsubstituted (i.e., N or NR wherein R is H or another substituent, if defined).
- the heterocyclic ring may be attached to its pendant group at any heteroatom or carbon atom that results in a stable structure.
- the heterocyclic rings described herein may be substituted on carbon or on a nitrogen atom if the resulting compound is stable.
- a nitrogen in the heterocycle may optionally be quaternized. It is preferred that when the total number of S and O atoms in the heterocycle exceeds 1, then these heteroatoms are not adjacent to one another. It is preferred that the total number of S and O atoms in the heterocycle is not more than 1.
- heterocycle When the term “heterocycle” is used, it is intended to include heteroaryl.
- heterocycles include, but are not limited to, acridinyl, azocinyl, benzimidazolyl, benzofuranyl, benzothiofuranyl, benzoxazolyl, benzoxazolinyl, benzthiazolyl, benztriazolyl, benztetrazolyl, benzisoxazolyl, benzisothiazolyl, benzimidazolinyl, carbazolyl, 4aH-carbazolyl, carbolinyl, chromanyl, chromenyl, cinnolinyl, decahydroquinolinyl, 2H,6H-l,5,2-dithiazinyl, dihydrofuro[2,3-Z?]tetrahydrofuran, furanyl, furazanyl, imidazolidinyl, imidazolinyl, imi
- Preferred 5- to 10-membered heterocycles include, but are not limited to, pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, pyrazinyl, piperazinyl, piperidinyl, imidazolyl, imidazolidinyl, indolyl, tetrazolyl, isoxazolyl, mo ⁇ holinyl, oxazolyl, oxadiazolyl, oxazolidinyl, tetrahydrofuranyl, thiadiazinyl, thiadiazolyl, thiazolyl, triazinyl, triazolyl, benzimidazolyl, lH-indazolyl, benzofuranyl, benzothiofuranyl, benztetrazolyl, benzotriazolyl, benzis oxazolyl, benzoxazolyl, oxindolyl, benzoxazol
- Preferred 5 to 6 membered heterocycles include, but are not limited to, pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, pyrazinyl, piperazinyl, piperidinyl, imidazolyl, imidazolidinyl, indolyl, tetrazolyl, isoxazolyl, mo ⁇ holinyl, oxazolyl, oxadiazolyl, oxazolidinyl, tetrahydrofuranyl, thiadiazinyl, thiadiazolyl, thiazolyl, triazinyl, and triazolyl.
- fused ring and spiro compounds containing, for example, the above heterocycles are also included.
- aromatic heterocyclic group or “heteroaryl” is intended to mean a stable monocyclic and polycyclic aromatic hydrocarbons that include at least one heteroatom ring member such as sulfur, oxygen, or nitrogen.
- Heteroaryl groups include, without limitation, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, triazinyl, furyl, quinolyl, isoquinolyl, thienyl, imidazolyl, thiazolyl, indolyl, pyrroyl, oxazolyl, benzofuryl, benzothienyl, benzthiazolyl, isoxazolyl, pyrazolyl, triazolyl, tetrazolyl, indazolyl, 1,2,4-thiadiazolyl, isothiazolyl, purinyl, carbazolyl, benzimidazolyl, indolinyl, benzodioxolanyl, benzodioxane, and the like.
- Heteroaryl groups can be substituted or unsubstituted.
- the nitrogen atom may be substituted or unsubstituted (i.e., N or NR wherein R is H or another substituent, if defined).
- the nitrogen and sulfur heteroatoms may optionally be oxidized (i.e., N— »0 and S(O)p). It is to be noted that total number of S and O atoms in the aromatic heterocycle is not more than 1.
- Bridged rings are also included in the definition of heterocycle. A bridged ring occurs when one or more atoms (i.e., C, O, N, or S) link two non-adjacent carbon or nitrogen atoms.
- Preferred bridges include, but are not limited to, one carbon atom, two carbon atoms, one nitrogen atom, two nitrogen atoms, and a carbon-nitrogen group. It is noted that a bridge always converts a monocyclic ring into a tricyclic ring. When a ring is bridged, the substituents recited for the ring may also be present on the bridge.
- counterion is used to represent a small, negatively charged species such as chloride, bromide, hydroxide, acetate, sulfate, and the like.
- nitrogen atoms e.g., amines
- these may be converted to N-oxides by treatment with an oxidizing agent (e.g., mCPBA and/or hydrogen peroxides) to afford other compounds of this invention.
- shown and claimed nitrogen atoms are considered to cover both the shown nitrogen and its N-oxide (N-»O) derivative.
- these can be replaced by silicon atoms, provided they do not form Si-N or Si-O bond.
- any variable occurs more than one time in any constituent or formula for a compound, its definition at each occurrence is independent of its definition at every other occurrence.
- a group is shown to be substituted with 0-3 R 3a , then said group may optionally be substituted with up to three R 3a groups and R 3a at each occurrence is selected independently from the definition of R 3a .
- combinations of substituents and/or variables are permissible only if such combinations result in stable compounds.
- phrases "pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio.
- pharmaceutically acceptable salts refer to derivatives of the disclosed compounds wherein the parent compound is modified by making acid or base salts thereof. Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic groups such as amines; and alkali or organic salts of acidic groups such as carboxylic acids.
- the pharmaceutically acceptable salts include the conventional non-toxic salts or the quaternary ammonium salts of the parent compound formed, for example, from non-toxic inorganic or organic acids.
- such conventional non-toxic salts include those derived from inorganic acids such as hydrochloric, hydrobromic, sulfuric, sulfamic, phosphoric, and nitric; and the salts prepared from organic acids such as acetic, propionic, succinic, glycolic, stearic, lactic, malic, tartaric, citric, ascorbic, pamoic, maleic, hydroxymaleic, phenylacetic, glutamic, benzoic, salicylic, sulfanilic, 2- acetoxybenzoic, fumaric, toluenesulfonic, methanesulfonic, ethane disulfonic, oxalic, and isethionic, and the like.
- the pharmaceutically acceptable salts of the present invention can be synthesized from the parent compound which contains a basic or acidic moiety by conventional chemical methods.
- such salts can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred.
- Lists of suitable salts are found in Remington's Pharmaceutical Sciences, 18th ed., Mack Publishing Company, Easton, PA, 1990, the disclosure of which is hereby incorporated by reference.
- compounds of formula I may have prodrug forms. Any compound that will be converted in vivo to provide the bioactive agent ⁇ i.e., a compound of formula I) is a prodrug within the scope and spirit of the invention.
- a prodrug within the scope and spirit of the invention.
- Various forms of prodrugs are well known in the art. For examples of such prodrug derivatives, see: a) Design of Prodrugs, edited by H. Bundgaard, (Elsevier, 1985), and Methods in
- compositions containing a carboxy group can form physiologically hydrolyzable esters which serve as prodrugs by being hydrolyzed in the body to yield formula I compounds per se.
- prodrugs are preferably administered orally since hydrolysis in many instances occurs principally under the influence of the digestive enzymes. Parenteral administration may be used where the ester per se is active, or in those instances where hydrolysis occurs in the blood.
- physiologically hydrolyzable esters of compounds of formula I include C ⁇ galkyl , C ⁇ alkylbenzyl, 4-methoxybenzyl, indanyl, phthalyl, methoxymethyl, Ci -6 alkanoyloxy-Ci.galkyl, e.g.
- esters used, for example, in the penicillin and cephalosporin arts. Such esters may be prepared by conventional techniques known in the art.
- prodrugs are well known in the art and described in, for example, Medicinal Chemistry: Principles and Practice, ed. F. D. King, The Royal Society of Chemistry, Cambridge, UK, 1994, which is incorporated herein by reference in its entirety.
- Isotopically labeled compounds of the present invention i.e., wherein one or more of the atoms described are replaced by an isotope of that atom (e.g., C replaced by 13 C or by 14 C; and isotopes of hydrogen include tritium and deuterium), are also provided herein.
- Such compounds have a variety of potential uses, e.g., as standards and reagents in determining the ability of a potential pharmaceutical to bind to target proteins or receptors, or for imaging compounds of this invention bound to biological receptors in vivo or in vitro.
- Compounds of the present invention are, subsequent to their preparation, preferably isolated and purified to obtain a composition containing an amount by weight equal to or greater than 98%, preferably 99%, compound of the present invention ("substantially pure"), which is then used or formulated as described herein. Such “substantially pure” compounds are also contemplated herein as part of the present invention.
- “Stable compound” and “stable structure” are meant to indicate a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent. It is preferred that compounds of the present invention do not contain a N-halo, S(O) 2 H, or S(O)H group.
- solvate means a physical association of a compound of this invention with one or more solvent molecules, whether organic or inorganic. This physical association includes hydrogen bonding. In certain instances the solvate will be capable of isolation, for example when one or more solvent molecules are incorporated in the crystal lattice of the crystalline solid.
- Solvate encompasses both solution-phase and isolable solvates. Exemplary solvates include hydrates, ethanolates, methanolates, isopropanolates and the like. Methods of solvation are generally known in the art.
- the term "patient” encompasses all mammalian species.
- treating cover the treatment of a disease-state in a mammal, particularly in a human, and include: (a) preventing the disease-state from occurring in a mammal, in particular, when such mammal is predisposed to the disease-state but has not yet been diagnosed as having it; (b) inhibiting the disease-state, i.e., arresting it development; and/or (c) relieving the disease-state, i.e., causing regression of the disease state.
- Therapeutically effective amount is intended to include an amount of a compound of the present invention that is effective when administered alone or in combination to inhibit factor XIa and/or plasma kallikrein or to treat the disorders listed herein.
- the term refers to combined amounts of the active ingredients that result in the therapeutic effect, whether administered in combination, serially or simultaneously.
- the combination of compounds is preferably a synergistic combination. Synergy, as described, for example, by Chou and Talalay, Adv. Enzyme Regul. 1984, 22:27-55, occurs when the effect (in this case, prevention of thrombosis) of the compounds when administered in combination is greater than the additive effect of the compounds when administered alone as a single agent.
- composition means a composition comprising a compound of the invention in combination with at least one additional pharmaceutically acceptable carrier.
- a “pharmaceutically acceptable carrier” refers to media generally accepted in the art for the delivery of biologically active agents to animals, in particular, mammals, including, i.e., adjuvant, excipient or vehicle, such as diluents, preserving agents, fillers, flow regulating agents, disintegrating agents, wetting agents, emulsifying agents, suspending agents, sweetening agents, flavoring agents, perfuming agents, antibacterial agents, antifungal agents, lubricating agents and dispensing agents, depending on the nature of the mode of administration and dosage forms.
- Pharmaceutically acceptable carriers are formulated according to a number of factors well within the purview of those of ordinary skill in the art.
- compositions include, without limitation: the type and nature of the active agent being formulated; the subject to which the agent-containing composition is to be administered; the intended route of administration of the composition; and the therapeutic indication being targeted.
- Pharmaceutically acceptable carriers include both aqueous and nonaqueous liquid media, as well as a variety of solid and semi-solid dosage forms. Such carriers can include a number of different ingredients and additives in addition to the active agent, such additional ingredients being included in the formulation for a variety of reasons, e.g., stabilization of the active agent, binders, etc., well known to those of ordinary skill in the art.
- EDC EDCHCl
- EDCI or EDCIHCl
- EDAC 3-ethyl-3'-
- HOBt 1-hydroxybenzotriazole hydrate Hunig's base ⁇ , ⁇ -diisopropylethyl amine
- LiHMDS Lithium bis(trimethylsilyl amide) mCPBA /weto-chloroperbenzoic acid
- the compounds of the present invention can be prepared in a number of ways known to one skilled in the art of organic synthesis.
- the compounds of the present invention can be synthesized using the methods described below, together with synthetic methods known in the art of synthetic organic chemistry, or by variations thereon as appreciated by those skilled in the art. Preferred methods include, but are not limited to, those described below.
- the reactions are performed in a solvent appropriate to the reagents and materials employed and suitable for the transformations being effected. It will be understood by those skilled in the art of organic synthesis that the functionality present on the molecule should be consistent with the transformations proposed. This will sometimes require a judgment to modify the order of the synthetic steps or to select one particular process scheme over another in order to obtain a desired compound of the invention.
- Representative pyridine compounds of this invention can be prepared as shown in Scheme 1. Suzuki coupling between an appropriately functionalized pyridine, such as Ia, and an appropriately substituted aryl or heteroaryl boronic acid or ester Ib in the presence of a base such as aqueous sodium carbonate in a solvent such as toluene using a catalyst such as tetrafe ⁇ triphenylphosphine)palladium(O) provides the biaryl compound Ic.
- a base such as aqueous sodium carbonate
- a solvent such as toluene
- a catalyst such as tetrafe ⁇ triphenylphosphine
- the pyridine ⁇ -oxide derivatives Ig can be prepared by oxidation of If with a suitable oxidant such as w-chloroperbenzoic acid in a solvent such as chloroform or dichloromethane. Further manipulation of functional groups on R 3 and R 4 in compounds of formulas If and Ig using methods known to one skilled in the art of organic synthesis will give additional compounds of this invention.
- the R 3 moiety can be introduced via a Suzuki coupling strategy later in the synthesis as shown in Scheme 2.
- Negishi coupling between an appropriately substituted acid chloride, derived from suitably substituted nicotinic acid derivatives 2a, and an appropriately functionalized organozinc reagent using a catalyst such as tetr ⁇ fe(triphenylphosphine)palladium(0) in a solvent such as THF provides a ketone of formula 2b.
- ketone 2b can be prepared by addition of Grignard or organolithium reagents to an ester or Weinreb amide derived from nicotinic acid derivative 2a. Condensation of 2b with hydroxylamine hydrochloride generates the oxime, which can be reduced to the primary amine 2c with zinc dust and TFA. Amide coupling between 2c and carboxylic acid Ie employing suitable coupling reagents as described above in Scheme 1 gives 2d.
- Suzuki coupling between 3- bromopyridine 2d and an appropriately substituted aryl or heteroaryl boronic acid or ester Ib in the presence of a base, such as anhydrous potassium phosphate, in a solvent, such as dimethylsulfoxide, using a catalyst, such as Pd(dppf)Cl2»CH 2 Cl2 complex, provides the biaryl compound If.
- a base such as anhydrous potassium phosphate
- a catalyst such as Pd(dppf)Cl2»CH 2 Cl2 complex
- Additional pyridine compounds of this invention can be prepared as shown in Scheme 3. Negishi coupling between an appropriately substituted acid chloride, derived from isonicotinic acid derivatives 3a, and an appropriately substituted organozinc reagent using a catalyst, such as te£rate(triphenylphosphine)palladium(0), in a solvent, such as THF, provides ketone 3b. Alternately, ketone 3b can be prepared by addition of Grignard or organolithium reagents to the corresponding ester or Weinreb amide derived from isonicotinic acid derivatives 3 a.
- a catalyst such as te£rate(triphenylphosphine)palladium(0)
- Representative pyridone compounds of this invention can be prepared from protected hydroxypyridines of formulae 4a, 5a, and 6a as shown in Schemes 4-6 by applying the synthetic methods described for Schemes 1-3.
- the protecting group R for example Me or Bn, can be removed with either boron tribromide or HCl to reveal the corresponding pyridone compounds of this invention.
- pyrimidine compounds of this invention can be prepared as shown in Scheme 7.
- Suzuki coupling between an appropriately functionalized pyrimidine 7a and an appropriately substituted aryl or heteroaryl boronic acid or ester Ib, as described for the conversion of Ia to Ic provides the biaryl compound.
- Basic hydrolysis affords acid derivatives 7b.
- Negishi coupling between the acid chloride, derived from acid derivatives 7b, and an appropriately substituted organozinc reagent employing reagents described in Scheme 2 provides ketone 7c.
- ketone 7c can be prepared by addition of Grignard or organolithium reagents to the corresponding ester or Weinreb amide derived from acid derivatives 7b.
- pyrimidine compounds of this invention can be prepared as shown in Scheme 8.
- the pyrimidone can be converted to the chloro pyrimidine 8d in two steps with phosphorus oxy chloride and then reprotection of the amine with Boc-anhydride.
- the pyrimidone can be converted to the corresponding triflate 8e with sodium hydride and
- N-phenyltrifluoromethanesulfonimide N-phenyltrifluoromethanesulfonimide.
- Suzuki coupling between an appropriately functionalized pyrimidine 8d/8e and an appropriately substituted aryl or heteroaryl boronic acid or ester Ib, as described for the conversion of Ia to Ic, provides 8f.
- the resulting amine is coupled with carboxylic acid Ie employing suitable coupling reagents as described in Scheme 1 to give 8g.
- Further manipulation of functional groups on A, R 3 , and R 4 using methods known to one skilled in the art of organic synthesis will give additional compounds of the invention.
- Scheme 9 describes the synthesis of a specific example of R 3 - B(OH) 2 (Ib) when R 3 is a 4-hydroxy quinolinone moiety.
- Intramolecular Friedel- Craft acylation of 9a in the presence of an acid, such as polyphosphoric acid (PPA), at elevated temperature provides the 4-hydroxy quinolinone derivated 9b.
- Aryl bromide 9b is then subjected to a palladium mediated coupling with a diboron species such as bis(neopentyl glycolato)diboron to provide the corresponding boronate 9c using the method of Ishiyama, T. etal. (J. Org. Chem. 1995, 60(23), 7508-7510).
- the boronate can be used in place of boronic acids for coupling to the aryl/heteroaryl halides or triflates or the boronate can be converted to the boronic acid.
- single stereoisomers can be obtained by oxazaborolidine-catalyzed enantioselective reduction of oxime ethers, derived from 2b, 3b, 4b, 5b, 6b, and 7c, as described by Demir (Demir, A. S. et al HeIv. CHm. Acta., 2003, 86, 91).
- the compound of the instant invention herein described may have asymmetric center(s).
- the chiral carbon atom in Formula (I) as indicated below exists in either as S or R configuration.
- Reverse phase preparative HPLC was carried out using a Shimadzu Preparative HPLC system running DiscoveryVP software using Method A: YMC Sunfire 5 ⁇ m Cl 8 30x100 mm column with a 10 min gradient at 40 mL/min from 100% A to 100% B (A: 10% methanol, 89.9% water, 0.1% TFA; B: 10% water, 89.9% methanol, 0.1% TFA, UV 220 nm), Method B: Phenomenex AXIA Luna 5 ⁇ m Cl 8 30 x 75 mm column with a 10 min gradient at 40 mL/min from 100% A to 100% B (A: 10% acetonitrile, 89.9% water, 0.1% TFA; B: 10% water, 89.9% acetonitrile, 0.1% TFA, UV 220 nm), Method C: Phenomenex Luna 5 ⁇ m C18 30 x l00 mm column with a 10 min gradient at 40 mL/min from 100% A to 100% B (A: 10% ace
- IB 2-Phenyl-l-(5-phenyl-pyridin-3-yl)-ethylamine, bis- trifluoroacetic acid salt: To a cooled (0 0 C), yellow solution of IA (0.437 g, 2.38 mmol) in THF (6.0 mL) was added dropwise 1.0 N lithium Zr ⁇ (trimethylsilyl)amide in THF (2.50 mL, 2.50 mmol). The resulting dark yellow solution was stirred at 0 0 C for 20 min. Subsequently, a 2.0 M benzylmagnesium chloride solution in THF (1.25 mL, 2.50 mmol) was added dropwise to give a dark orange solution. The reaction was stirred at 0 0 C for 15 min and then quenched with sat. NH 4 Cl, diluted with water and
- Example 1 A solution of 1C (0.080 g) in 30% TFA in CH 2 Cl 2 (5.0 mL) was stirred for 30 min and then concentrated. Prep. HPLC afforded, after lyophilization from water, 0.058 g (58%, white, fluffy solid) of Example 1 as the bis- TFA salt.
- 3B Benzylzinc chloride: To a cooled (0° C), 0.5 M solution OfZnCl 2 in THF (23.8 mL, 11.9 mmol) was added dropwise 2.0 M benzylmagnesium chloride (5.7 mL, 11.3 mmol) to give a milky-white suspension. After 30 min, the reaction was warmed to rt for 10-15 min and then used in the next step. [00156] 3C. l-(5-Bromo-pyridin-3-yl)-2-phenyl-ethanone: To a cooled (0° C), 0.5 M solution OfZnCl 2 in THF (23.8 mL, 11.9 mmol) was added dropwise 2.0 M benzylmagnesium chloride (5.7 mL, 11.3 mmol) to give a milky-white suspension. After 30 min, the reaction was warmed to rt for 10-15 min and then used in the next step. [00156] 3C. l-(5-Bromo-pyr
- [00162] 4B ⁇ «s-4-[2-Phenyl-l-(2-phenyl-pyridin-4-yl)-ethylcarbamoyl]- cyclohexylmethyty-carbamic acid tert-butyl ester.
- the vial was capped with a Tefion- coated cap under a blanket of argon.
- the purple suspension was stirred at rt for 1 h and then placed in a preheated (90 0 C) shaker or oil bath. After 13 h, the reaction was cooled to rt, diluted with CH2CI2, and filtered through a 0.45 ⁇ m nylon filter. The filtrate was concentrated to yield an orange solid (0.069 g). Ethyl acetate (1.5 mL) was added. The mixture was sonicated, and the solid was collected by filtration, rinsed with EtOAc (1 mL), air-dried, then dried under vacuum to give the biaryl compound as a white solid (0.0418 g, 77%).
- Example 5 was prepared as the TFA salt starting from compound 4B following the procedure described in Example 2.
- 1 H NMR 500 MHz, CD 3 OD
- Example 6 [4-(4- ⁇ l-[( ⁇ >* ⁇ /w-4-aminomethyl-cyclohexanecarbonyI)-amino]-2-phenyl-ethyl ⁇ - pyridin-2-yl)-phenyl]-carbamic acid methyl ester, ⁇ is-trifluoroacetic acid salt [00165]
- Example 6 was prepared as the bis-TFA salt starting from compound
- _r «ns-4-Aminomethyl-cyclohexanecarboxylic acid ⁇ l-[5-(4-hydroxy-2-oxo-l,2- dihydro-quinolin-6-yl)-pyridin-3-yl]-2-phenyl-ethyl ⁇ -amide, /j/s-trifluoroacetic acid salt [00166] 7A.
- iV-(4-Bromo-phenyl)-malonamic acid ethyl ester To a solution of 4-bromo aniline (1.78 g, 10.3 mmol) in dichloromethane (20 mL) and TEA (2.0 mL, 15.5 mmol) was added dropwise ethyl 3-chloro-3-oxo-propionate (1.6 mL, 12.4 mmol) at 0 0 C. After 2 h, the mixture was diluted with dichloromethane (20 mL), washed with 1.0 N HCl (Ix), brine (2x), dried over sodium sulfate, filtered and concentrated.
- Example 7 was prepared as the bis-TFA salt starting from compound 3D (enantiomer B) following the procedures described for 3E-G, by replacing 4-(methoxycarbonylamino)phenylboronic acid with 7C. MS 497.2
- 8B 5-Bromo-6-chloro-nicotinic acid: To 8A (10 g, 45 mmol) was added tetra-methylammonium chloride (5.4 g, 49 mmol) and phosphorous oxychloride (20 mL) and the reaction was heated at reflux for 3 h. The reaction was poured onto ice and stirred 2 h. The solid was filtered off, dissolved in EtOAc (300 mL) and dried (Na 2 SO ⁇ ). After filtration and concentration, 10.5g (97%) of 8B as a pink solid was collected.
- 8D 6-Benzyloxy-5-bromo- ⁇ '-methoxy-iV-methyl-nicotinamide: To 8C (3.29 g, 10.6 mmol) in DCM (20 mL) was added carbonyl diimidazole (1.9 g, 11.7 mmol) and TEA (2.98 mL, 21 mmol) and the reaction was stirred 1.5 h. N,O- Dimethylhydroxylamine (3.2 g, 32 mmol) was added and the reaction was stirred 24 h. The reaction was quenched with water and extracted with DCM (3 x 50 mL), washed with brine and dried (Na 2 SO ⁇ .
- Example 8 was prepared as the TFA salt starting from compound
- Example 9 tfr ⁇ Hs-4-aminomethyl-cyclohexanecarboxylic acid [2-phenyl-l-(6-phenyl- pyrimidin-4-yl)-ethyl]-amide, trifluoroacetic acid salt [00177]
- Example 9 was prepared as the TFA salt following the procedures described for 3A, 3C-E, and 3G, by replacing 5-bromonicotinic acid with 6-phenyl- pyrimidine-4-carboxylic acid. MS 415.3 (M+H) + .
- Example 10 was prepared as the TFA salt following the procedures described for 3F-G and IC-D, by replacing 3E with 1OB. MS 488.3 (M+H) + .
- Example 11 was prepared as the TFA salt following the procedures described for 3F-G and IC-D, by replacing 3E with 1OB (enantiomer A). The enantiomeric excess was determined to be 73% ee by chiral analytical HPLC
- Example 12 was prepared as the TFA salt following the procedures described for 3F-G and IC-D, by replacing 3E with 1OB (enantiomer A) and by replacing 4-(methoxycarbonylamino)phenylboronic acid with 7C. MS 498.3 (M+H) + .
- Example 13 fr ⁇ ns ⁇ -Aminomethyl-cyelohexanecarboxylic acid [l-(2'-amino-[2,4']bipyridinyl- 4-yl)-2-phenyl-ethyl]-amide, *ra-trifluoroacetic acid salt [00184] 13A.
- Example 13B A suspension of 13A (0.029 g, 0.037 mmol) in sat. NH 4 OH (1.0 mL) was heated in a microwave vial at 150 0 C for 2 h. The resulting clear, colorless solution was concentrated to give an off-white solid. Prep. HPLC yielded, after lyophilization from CH 3 CNZH 2 O, 0.0050 g (17%, white solid) of Example 13 as the tris-TFA salt. MS 430.3 (M+H) + .
- Table 1 summarizes representative examples, the synthesis of which is described above, of the compounds in the present invention.
- thromboembolic disorders are a circulatory disease caused by blood clots (i.e., diseases involving fibrin formation, platelet activation, and/or platelet aggregation).
- blood clots i.e., diseases involving fibrin formation, platelet activation, and/or platelet aggregation.
- thromboembolic disorders as used herein includes arterial cardiovascular thromboembolic disorders, venous cardiovascular or cerebovascular thromboembolic disorders, and thromboembolic disorders in the chambers of the heart or in the peripheral circulation.
- thromboembolic disorders also includes specific disorders selected from, but not limited to, unstable angina or other acute coronary syndromes, atrial fibrillation, first or recurrent myocardial infarction, ischemic sudden death, transient ischemic attack, stroke, atherosclerosis, peripheral occlusive arterial disease, venous thrombosis, deep vein thrombosis, thrombophlebitis, arterial embolism, coronary arterial thrombosis, cerebral arterial thrombosis, cerebral embolism, kidney embolism, pulmonary embolism, and thrombosis resulting from medical implants, devices, or procedures in which blood is exposed to an artificial surface that promotes thrombosis.
- the medical implants or devices include, but are not limited to: prosthetic valves, artificial valves, indwelling catheters, stents, blood oxygenators, shunts, vascular access ports, ventricular assist devices and artif ⁇ cal hearts or heart chambers, and vessel grafts.
- the procedures include, but are not limited to: cardiopulmonary bypass, percutaneous coronary intervention, and hemodialysis.
- thrombosis includes vessel occlusion (e.g., after a bypass) and reocclusion (e.g., during or after percutaneous transluminal coronary angioplasty).
- the thromboembolic disorders may result from conditions including but not limited to atherosclerosis, surgery or surgical complications, prolonged immobilization, arterial fibrillation, congenital thrombophilia, cancer, diabetes, effects of medications or hormones, and complications of pregnancy.
- the anticoagulant effect of compounds of the present invention is believed to be due to inhibition of serine proteases involved in the coagulation cascade and/or contact activation system, more specifically, inhibition of the coagulation factors: factor XIa, factor Vila, factor IXa, factor Xa, plasma kallikrein or thrombin.
- thrombosis refers to formation or presence of a thrombus (pi.
- thrombi clotting within a blood vessel which may cause ischemia or infarction of tissues supplied by the vessel.
- embolic stroke refers to sudden blocking of an artery by a clot or foreign material which has been brought to its site of lodgment by the blood current.
- thromboembolism refers to obstruction of a blood vessel with thrombotic material carried by the blood stream from the site of origin to plug another vessel.
- stroke refers to embolic stroke or atherothrombotic stroke arising from occlusive thrombosis in the carotid communis, carotid interna, or intracerebral arteries.
- the compounds of this invention also are inhibitors of plasma kallikrein and are useful as anti-inflammatory agents for the treatment or prevention of diseases associated with an activation of the contact activation system (i.e., plasma kallikrein associated disorders).
- a contact activation system disorder is a disease caused by activation of blood on artificial surfaces, including prosthetic valves or other implants, indwelling catheters, stents, cardiopulmonary bypass, hemodialysis, microorganism (e.g., bacteria, virus), or other procedures in which blood is exposed to an artificial surface that promotes contact activation, blood clots (i.e., diseases involving fibrin formation, platelet activation, and/or platelet aggregation).
- Contact activation can also occur on cell surfaces, cellular receptors or extracellular matrices, Diseases of the contact activation system also include systemic inflammatory response syndrome, sepsis, acute respiratory distress syndrome, hereditary angioedema or other inherited or aquired def ⁇ cencies of contact activation components or their inhibitors (plasma kallikrein, factor XIIa, high molecular weight kininogen, Cl-esterase inhibitor). It may also include acute and chronic inflammations of joints, vessels, or other mammalian organs.
- the effectiveness of compounds of the present invention as inhibitors of the coagulation factors XIa, Vila, IXa, Xa, plasma kallikrein or thrombin can be determined using a relevant purified serine protease, respectively, and an appropriate synthetic substrate. The rate of hydrolysis of the chromogenic or fluorogenic substrate by the relevant serine protease was measured both in the absence and presence of compounds of the present invention.
- More preferred compounds have Kj's of equal to or less than 5 ⁇ M, preferably equal to or less than 1 ⁇ M, more preferably equal to or less than 0.5 ⁇ M.
- Factor Xa determinations were made in 0.1 M sodium phosphate buffer at a pH of 7.4 containing 0.2 M sodium chloride and 0.5% PEG 8000. Determinations were made using purified human Factor Xa (Haematologic Technologies) at a final assay concentration of 150-1000 pM and the synthetic substrate S-2222 (Bz-IIe-GIu (gamma-OMe, 50%)-Gly-Arg-pNA; Chromogenix) at a concentration of 0.0002-0.0003 M. In general, compounds tested in the Factor Xa assay are considered to be active if they exhibit a Kj of equal to or less than 15 ⁇ M.
- Plasma kallikrein determinations were made in 0.1 M sodium phosphate buffer at a pH of 7.4 containing 0.2 M sodium chloride and 0.5% PEG 8000. Determinations were made using purified human kallikrein (Enzyme Research Laboratories) at a final assay concentration of 200 pM and the synthetic substrate S- 2302 (H-(D)-Pro-Phe-Arg-pNA; Chromogenix) at a concentration of 0.00008-0.0004 M. The Km value used for calculation of Ki was 0.00005 to 0.00007 M. In general, Compounds tested in the plasma kallikrein assay are considered to be active if they exhibit a Kj of equal to or less than 15 ⁇ M.
- Thrombin determinations were made in 0.1 M sodium phosphate buffer at a pH of 7.4 containing 0.2 M sodium chloride and 0.5% PEG 8000. Determinations were made using purified human alpha thrombin (Haematologic
- preferred compounds of the present invention have demonstrated Kj values of equal to or less than 15 ⁇ M in at least one of the above assays, thereby confirming the utility of the compounds of the present invention as effective inhibitors of the coagulation cascade and/or contact activation system, and useful as anticoagulants for the prevention or treatment of thromboembolic disorders in mammals and/or as anti-inflammatory agents for the prevention or treatment of inflammatory disorders in mammals.
- K m The Michaelis constant,K m , for substrate hydrolysis by each protease was determined at 25 0 C using the method of Lineweaver and Burk. Values of Kj were determined by allowing the protease to react with the substrate in the presence of the inhibitor.
- V 0 is the velocity of the control in the absence of inhibitor
- v s is the velocity in the presence of inhibitor
- I is the concentration of inhibitor
- A is the minimum activity remaining (usually locked at zero); B is the maximum activity remaining (usually locked at 1.0); n is the Hill coefficient, a measure of the number and cooperativity of potential inhibitor binding sites;
- IC50 is the concentration of inhibitor that produces 50% inhibition under the assay conditions; Ki is the dissociation constant of the enzyme:inhibitor complex;
- S is the concentration of substrate
- K m is the Michaelis constant for the substrate.
- the effectiveness of compounds of the present invention as antithrombotic agents can be determined using relevant in vivo thrombosis models, including In Vivo Electrically-induced Carotid Artery Thrombosis Models and In Vivo Rabbit Arterio-venous Shunt Thrombosis Models.
- ECAT Electrode-induced Carotid Artery Thrombosis
- Ther 2000, 295, 212-218 can be used in this study.
- Male New Zealand White rabbits are anesthetized with ketamine (50 mg/kg + 50 mg/kg/h IM) and xylazine (10 mg/kg + 10 mg/kg/h IM). These anesthetics are supplemented as needed.
- An electromagnetic flow probe is placed on a segment of an isolated carotid artery to monitor blood flow. Test agents or vehicle will be given (i.v., Lp., s.c, or orally) prior to the initiation of thrombosis. Thrombus formation is induced by electrical stimulation of the carotid artery for 3 min at 4 mA using an external stainless-steel bipolar electrode.
- Carotid blood flow is measured continuously over a 90-min period to monitor thrombus-induced occlusion.
- Total carotid blood flow over 90 min is calculated by trapezoidal rule.
- Average carotid flow over 90 min is then determined by converting total carotid blood flow over 90 min to percent of total control carotid blood flow, which would result if control blood flow had been maintained continuously for 90 min.
- the ED50 (dose that increased average carotid blood flow over 90 min to 50% of the control) of compounds are estimated by a nonlinear least square regression program using the Hill sigmoid E 1H a x equation (DeltaGraph; SPSS Inc., Chicago, IL).
- the rabbit AV shunt model described by Wong et al. (Wong, P. C. et al. J Pharmacol Exp Ther 2000, 292, 351-357), can be used in this study.
- Male New Zealand White rabbits are anesthetized with ketamine (50 mg/kg + 50 mg/kg/h IM) and xylazine (10 mg/kg + 10 mg/kg/h IM). These anesthetics are supplemented as needed.
- the femoral artery, jugular vein and femoral vein are isolated and catheterized.
- a saline-filled AV shunt device is connected between the femoral arterial and the femoral venous cannulae.
- the AV shunt also contains an 8-cm-long 2-0 silk thread (Ethicon, Somerville, NJ). Blood flows from the femoral artery via the AV-shunt into the femoral vein. The exposure of flowing blood to a silk thread induces the formation of a significant thrombus. Forty minutes later, the shunt is disconnected and the silk thread covered with thrombus is weighed.
- Test agents or vehicle will be given (i.v., i.p., s.c, or orally) prior to the opening of the AV shunt.
- the percentage inhibition of thrombus formation is determined for each treatment group.
- the ID50 values (dose which produces 50% inhibition of thrombus formation) are estimated by a nonlinear least square regression program using the Hill sigmoid Emax equation (DeltaGraph; SPSS Inc., Chicago, IL).
- the anti-inflammatory effect of these compounds can be demonstrated in an Evans Blue dye extravasation assay using Cl -esterase inhibitor deficient mice.
- mice are dosed with a compound of the present invention, Evans Blue is injected via the tail vein, and extravasation of the blue dye is determined by spectrophotometric means from tissue extracts.
- Evans Blue is injected via the tail vein, and extravasation of the blue dye is determined by spectrophotometric means from tissue extracts.
- Read-outs to assess the benefit of the compounds of the present invention include for example reduced platelet loss, reduced platelet / white blood cell complexes, reduced neutrophil elastase levels in plasma, reduced activation of complement factors, and reduced activation and/or consumption of contact activation proteins (plasma kallikrein, factor XH, factor XI, high molecular weight kininogen, Cl-esterase inhibitors).
- the utility of the compounds of the current invention to reduce or prevent the morbidity and/or mortality of sepsis can be assessed by injecting a mammalian host with bacteria or viruses or extracts there of and compounds of the present invention.
- Typical read-outs of the efficacy include changes in the LD50 and blood pressure preservation.
- the compounds of the present invention may also be useful as inhibitors of additional serine proteases, notably human thrombin, human plasma kallikrein and human plasmin. Because of their inhibitory action, these compounds are indicated for use in the prevention or treatment of physiological reactions, including blood coagulation, fibrinolysis, blood pressure regulation and inflammation, and wound healing catalyzed by the aforesaid class of enzymes. Specifically, the compounds have utility as drugs for the treatment of diseases arising from elevated thrombin activity of the aforementioned serine proteases, such as myocardial infarction, and as reagents used as anticoagulants in the processing of blood to plasma for diagnostic and other commercial purposes.
- additional serine proteases notably human thrombin, human plasma kallikrein and human plasmin. Because of their inhibitory action, these compounds are indicated for use in the prevention or treatment of physiological reactions, including blood coagulation, fibrinolysis, blood pressure regulation and inflammation, and wound healing catalyzed by the afores
- the compounds of the present invention can be administered alone or in combination with one or more additional therapeutic agents. These include other anti-coagulant or coagulation inhibitory agents, anti-platelet or platelet inhibitory agents, anti-inflammatory agents, thrombin inhibitors, or thrombolytic or fibrinolytic agents.
- the compounds are administered to a mammal in a therapeutically effective amount.
- therapeutically effective amount it is meant an amount of a compound of the present invention that, when administered alone or in combination with an additional therapeutic agent to a mammal, is effective to treat (i.e. prevent, inhibit or ameliorate) the thromboembolic and/or inflammatory disease condition or treat the progression of the disease in a host.
- administered in combination or “combination therapy” it is meant that the compound of the present invention and one or more additional therapeutic agents are administered concurrently to the mammal being treated.
- each component may be administered at the same time or sequentially in any order at different points in time. Thus, each component may be administered separately but sufficiently closely in time so as to provide the desired therapeutic effect.
- Compounds which can be administered in combination with the compounds of the present invention include, but are not limited to, anticoagulants, anti-thrombin agents, anti-platelet agents, fibrinolytics, hypolipidemic agents, antihypertensive agents, and anti-ischemic agents.
- anticoagulant agents include warfarin, heparin (either unfractionated heparin or any commercially available low molecular weight heparin, for example LOVENOXTM), synthetic pentasaccharide, direct acting thrombin inhibitors including hirudin and argatroban, as well as other factor Vila inhibitors, factor IXa inhibitors, factor Xa inhibitors (e.g., ArixtraTM, apixaban, rivaroxaban, LY-517717, DU-176b, DX-9065a, and those disclosed in WO 98/57951, WO 03/026652, WO 01/047919, and WO 00/076970), factor XIa inhibitors, and inhibitors of activated TAFI and PAI-I known in the art.
- warfarin heparin (either unfractionated heparin or any commercially available low molecular weight heparin, for example LOVENOXTM)
- synthetic pentasaccharide
- anti-platelet agents denotes agents that inhibit platelet function, for example, by inhibiting the aggregation, adhesion or granule-content secretion of platelets.
- agents include, but are not limited to, the various known non-steroidal anti-inflammatory drugs (NSAIDS) such as acetaminophen, aspirin, codeine, diclofenac, droxicam, fentaynl, ibuprofen, indomethacin, ketorolac, mefenamate, morphine, naproxen, phenacetin, piroxicam, sufentanyl, sulfinpyrazone, sulindac, and pharmaceutically acceptable salts or prodrugs thereof.
- NSAIDS non-steroidal anti-inflammatory drugs
- NSAIDS acetylsalicylic acid or ASA
- piroxicam are preferred.
- Other suitable platelet inhibitory agents include glycoprotein lib/Ilia antagonists (e.g., tirofiban, eptifibatide, abciximab, and integrelin), thromboxane-A2-receptor antagonists (e.g., ifetroban), thromboxane-A-synthetase inhibitors, phosphodiesterase-III (PDE-III) inhibitors (e.g., dipyridamole, cilostazol), and PDE-V inhibitors (such as sildenafil), protease-activated receptor 1 (PARl) antagonists (e.g., SCH-530348, SCH-203099, SCH-529153 and SCH-205831), and pharmaceutically acceptable salts or prodrugs thereof.
- glycoprotein lib/Ilia antagonists e.g., tirofi
- Suitable anti-platelet agents for use in combination with the compounds of the present invention, with or without aspirin, ADP (adenosine diphosphate) receptor antagonists, preferably antagonists of the purinergic receptors P 2 Yi and P 2 Yi 2 , with P 2 Yi2 being even more preferred.
- Preferred P 2 Yi 2 receptor antagonists include clopidogrel, ticlopidine, prasugrel, and AZD-6140, and pharmaceutically acceptable salts or prodrugs thereof.
- Ticlopidine and clopidogrel are also preferred compounds since they are known to be more gentle than aspirin on the gastro-intestinal tract in use. Clopidogrel is an even more preferred agent.
- thrombin inhibitors denotes inhibitors of the serine protease thrombin.
- various thrombin-mediated processes such as thrombin-mediated platelet activation (that is, for example, the aggregation of platelets, and/or the secretion of platelet granule contents including serotonin) and/or fibrin formation are disrupted.
- thrombin inhibitors are known to one of skill in the art and these inhibitors are contemplated to be used in combination with the present compounds.
- Such inhibitors include, but are not limited to, boroarginine derivatives, boropeptides, heparins, hirudin, argatroban, dabigatran, AZD-0837, and those disclosed in WO 98/37075 and WO 02/044145, and pharmaceutically acceptable salts and prodrugs thereof.
- Boroarginine derivatives and boropeptides include N-acetyl and peptide derivatives of boronic acid, such as C-terminal a-aminoboronic acid derivatives of lysine, ornithine, arginine, homoarginine and corresponding isothiouronium analogs thereof.
- hirudin includes suitable derivatives or analogs of hirudin, referred to herein as hirulogs, such as disulfatohirudin.
- thrombolytic (or fibrinolytic) agents or thrombolytics or fibrinolytics, as used herein, denotes agents that lyse blood clots (thrombi).
- Such agents include tissue plasminogen activator (TPA, natural or recombinant) and modified forms thereof, anistreplase, urokinase, streptokinase, tenecteplase (TNK), lanoteplase (nPA), factor Vila inhibitors, thrombin inhibitors, inhibitors of factors IXa, Xa, and XIa, PAI-I inhibitors (i.e., inactivators of tissue plasminogen activator inhibitors), inhibitors of activated TAFI, alpha-2-antiplasmin inhibitors, and anisoylated plasminogen streptokinase activator complex, including pharmaceutically acceptable salts or prodrugs thereof.
- TPA tissue plasminogen activator
- anistreplase refers to anisoylated plasminogen streptokinase activator complex, as described, for example, in European Patent Application No. 028,489, the disclosure of which is hereby incorporated herein by reference herein.
- urokinase as used herein, is intended to denote both dual and single chain urokinase, the latter also being referred to herein as prourokinase.
- Suitable anti-arrhythmic agents for use in combination with the present compounds include: Class I agents (such as propafenone); Class II agents (such as carvadiol and propranolol); Class III agents (such as sotalol, dofetilide, amiodarone, azimilide and ibutilide); Class IV agents (such as ditiazem and verapamil); K + channel openers such as I ⁇ ch inhibitors, and IK 111 - inhibitors (e.g., compounds such as those disclosed in WO01/40231).
- Class I agents such as propafenone
- Class II agents such as carvadiol and propranolol
- Class III agents such as sotalol, dofetilide, amiodarone, azimilide and ibutilide
- Class IV agents such as ditiazem and verapamil
- K + channel openers such as I ⁇ ch inhibitors, and IK 111 - inhibitors (e.g., compounds
- Suitable antihypertensive agents for use in combination with the compounds of the present invention include alpha adrenergic blockers; beta adrenergic blockers; calcium channel blockers (e.g., diltiazem, verapamil, nifedipine, amlodipine and mybefradil); diruetics (e.g., chlorothiazide, hydrochlorothiazide, flumethiazide, hydroflumethiazide, bendroflumethiazide, methylchlorothiazide, trichloromethiazide, polythiazide, benzthiazide, ethacrynic acid tricrynafen, chlorthalidone, furosemide, musolimine, bumetanide, triamtrenene, amiloride, spironolactone); renin inhibitors; angiotensin-converting enzyme (ACE) inhibitors (e.g., cap
- Dual ET- A/AT-1 antagonist e.g., compounds disclosed in WO 00/01389
- neutral endopeptidase (NEP) inhibitors e.g., neutral endopeptidase (NEP) inhibitors
- vasopepsidase inhibitors dual ACE/NEP inhibitors, e.g., omapatrilat gemopatrilat, nitrates
- ⁇ -blockers for example propanolol, nadolo, or carvedilol.
- Examples of suitable calcium channel blockers for use in combination with the compounds of the present invention include diltiazem, verapamil, nifedipine, amlodipine and mybefradil.
- Examples of suitable cardiac glycosides for use in combination with the compounds of the present invention include digitalis and ouabain.
- suitable diruetics for use in combination with the compounds of the present invention include: chlorothiazide, hydrochlorothiazide, flumethiazide, hydroflumethiazide, bendroflumethiazide, methylchlorothiazide, trichloromethiazide, polythiazide, benzthiazide, ethacrynic acid tricrynafen, chlorthalidone, furosemide, musolimine, bumetanide, triamtrenene, amiloride, and spironolactone.
- suitable mineralocorticoid receptor antagonists for use in combination with the compounds of the present invention include sprionolactone and eplirinone.
- Suitable anti-diabetic agents for use in combination with the compounds of the present invention include: biguanides (e.g., metformin); glucosidase inhibitors (e.g., acarbose); insulins (including insulin secretagogues or insulin sensitizers); meglitinides (e.g., repaglinide); sulfonylureas (e.g., glimepiride, glyburide and glipizide); biguanide/glyburide combinations (e.g., glucovance), thiozolidinediones (e.g., troglitazone, rosiglitazone and pioglitazone), PPAR-alpha agonists, PPAR-gamma agonists, PPAR alpha/gamma dual agonists, SGLT2 inhibitors, inhibitors of fatty acid binding protein (aP2) such as those disclosed in WO00/59506,
- Examples of suitable anti-depressant agents for use in combination with the compounds of the present invention include nefazodone and sertraline.
- Examples of suitable anti-inflammatory agents for use in combination with the compounds of the present invention include: prednisone; dexamethasone; enbrel; protein tyrosine kinase (PTK) inhibitors; cyclooxygenase inhibitors (including NSAIDs, and COX-I and/or COX-2 inhibitors); aspirin; indomethacin; ibuprofen; prioxicam; naproxen; celecoxib; and/or rofecoxib.
- Examples of suitable anti-osteoporosis agents for use in combination with the compounds of the present invention include alendronate and raloxifene.
- Examples of suitable hormone replacement therapies for use in combination with the compounds of the present invention include estrogen (e.g., congugated estrogens) and estradiol.
- Suitable anti-obesity agents for use in combination with the compounds of the present invention include orlistat, aP2 inhibitors (such as those disclosed in WO00/59506), and cannabinoid receptor CBl antagonists (e.g., rimonabant, AVE-1625, SR-147778, and CP-945598).
- Examples of suitable anti-anxiety agents for use in combination with the compounds of the present invention include diazepam, lorazepam, buspirone, and hydroxyzine pamoate.
- Examples of suitable anti-proliferative agents for use in combination with the compounds of the present invention include cyclosporin A, paclitaxel, adriamycin; epithilones, cisplatin, and carboplatin.
- Examples of suitable holesterol/lipid lowering agents and lipid profile therapies for use in combination with the compounds of the present invention include HMG-CoA reductase inhibitors (e..g, pravastatin, lovastatin, simvastatin, fluvastatin, atorvsatatin, rosuvastatin, and other statins), sequestrants (e.g., cholestyramine and colestipol), nicotonic acid, fenofibric acid derivatives (e.g., gemfibrozil, clofibrat, fenofibrate and benzaf ⁇ brate), probucol, choesterol absorption inhibitors, and cholesterol ester transfer protein inhibitors (e.g., CP-529414).
- HMG-CoA reductase inhibitors e.g, pravastatin, lovastatin, simvastatin, fluvastatin, atorvsatatin, rosuvastatin, and
- Administration of the compounds of the present invention i.e., a first therapeutic agent in combination with at least one additional therapeutic agent (i.e., a second therapeutic agent), preferably affords an efficacy advantage over the compounds and agents alone, preferably while permitting the use of lower doses of each.
- a lower dosage minimizes the potential of side effects, thereby providing an increased margin of safety.
- at least one of the therapeutic agents is administered in a sub-therapeutic dose. It is even more preferred that all of the therapeutic agents be administered in sub-therapeutic doses.
- Sub-therapeutic is intended to mean an amount of a therapeutic agent that by itself does not give the desired therapeutic effect for the condition or disease being treated. Synergistic combination is intended to mean that the observed effect of the combination is greater than the sum of the individual agents administered alone.
- the compounds of the present invention are also useful as standard or reference compounds, for example as a quality standard or control, in tests or assays involving the inhibition of thrombin, Factor Vila, IXa, Xa, XIa, and/or plasma kallikrein.
- Such compounds may be provided in a commercial Mt, for example, for use in pharmaceutical research involving thrombin, Factor Vila, IXa, Xa, XIa, and/or plasma kallikrein.
- XIa for example, a compound of the present invention could be used as a reference in an assay to compare its known activity to a compound with an unknown activity.
- the compounds of the present invention may also be used in diagnostic assays involving thrombin, Factor Vila, IXa, Xa, XIa, and/or plasma kallikrein.
- the presence of thrombin, Factor Vila, IXa, Xa XIa, and/or plasma kallikrein in an unknown sample could be determined by addition of the relevant chromogenic substrate, for example S2366 for Factor XIa, to a series of solutions containing test sample and optionally one of the compounds of the present invention. If production of pNA is observed in the solutions containing test sample, but not in the presence of a compound of the present invention, then one would conclude Factor XIa was present.
- Extremely potent and selective compounds of the present invention those having Kj values less than or equal to 0.001 ⁇ M against the target protease and greater than or equal to 0.1 ⁇ M against the other proteases, may also be used in diagnostic assays involving the quantitation of thrombin, Factor Vila, IXa, Xa, XIa, and/or plasma kallikrein in serum samples.
- the amount of Factor XIa in serum samples could be determined by careful titration of protease activity in the presence of the relevant chromogenic substrate, S2366, with a potent and selective Factor XIa inhibitor of the present invention.
- the present invention also encompasses an article of manufacture.
- article of manufacture is intended to include, but not be limited to, kits and packages.
- the article of manufacture of the present invention comprises: (a) a first container; (b) a pharmaceutical composition located within the first container, wherein the composition, comprises: a first therapeutic agent, comprising: a compound of the present invention or a pharmaceutically acceptable salt form thereof; and, (c) a package insert stating that the pharmaceutical composition can be used for the treatment of a thromboembolic and/or inflammatory disorder (as defined previously).
- the package insert states that the pharmaceutical composition can be used in combination (as defined previously) with a second therapeutic agent to treat a thromboembolic and/or inflammatory disorder.
- the article of manufacture can further comprise: (d) a second container, wherein components (a) and (b) are located within the second container and component (c) is located within or outside of the second container. Located within the first and second containers means that the respective container holds the item within its boundaries.
- the first container is a receptacle used to hold a pharmaceutical composition. This container can be for manufacturing, storing, shipping, and/or individual/bulk selling. First container is intended to cover a bottle, jar, vial, flask, syringe, tube (e.g., for a cream preparation), or any other container used to manufacture, hold, store, or distribute a pharmaceutical product.
- the second container is one used to hold the first container and, optionally, the package insert.
- the second container include, but are not limited to, boxes (e.g., cardboard or plastic), crates, cartons, bags (e.g., paper or plastic bags), pouches, and sacks.
- the package insert can be physically attached to the outside of the first container via tape, glue, staple, or another method of attachment, or it can rest inside the second container without any physical means of attachment to the first container.
- the package insert is located on the outside of the second container. When located on the outside of the second container, it is preferable that the package insert is physically attached via tape, glue, staple, or another method of attachment.
- the package insert is a label, tag, marker, etc. that recites information relating to the pharmaceutical composition located within the first container.
- the information recited will usually be determined by the regulatory agency governing the area in which the article of manufacture is to be sold (e.g., the United States Food and Drug Administration).
- the package insert specifically recites the indications for which the pharmaceutical composition has been approved.
- the package insert may be made of any material on which a person can read information contained therein or thereon.
- the package insert is a printable material (e.g., paper, plastic, cardboard, foil, adhesive-backed paper or plastic, etc.) on which the desired information has been formed (e.g., printed or applied).
- the compounds of this invention can be administered in such oral dosage forms as tablets, capsules (each of which includes sustained release or timed release formulations), pills, powders, granules, elixirs, tinctures, suspensions, syrups, and emulsions. They may also be administered in intravenous (bolus or infusion), intraperitoneal, subcutaneous, or intramuscular form, all using dosage forms well known to those of ordinary skill in the pharmaceutical arts. They can be administered alone, but generally will be administered with a pharmaceutical carrier selected on the basis of the chosen route of administration and standard pharmaceutical practice.
- the dosage regimen for the compounds of the present invention will, of course, vary depending upon known factors, such as the pharmacodynamic characteristics of the particular agent and its mode and route of administration; the species, age, sex, health, medical condition, and weight of the recipient; the nature and extent of the symptoms; the kind of concurrent treatment; the frequency of treatment; the route of administration, the renal and hepatic function of the patient, and the effect desired.
- a physician or veterinarian can determine and prescribe the effective amount of the drug required to prevent, counter, or arrest the progress of the thromboembolic disorder.
- the daily oral dosage of each active ingredient when used for the indicated effects, will range between about 0.001 to 1000 mg/kg of body weight, preferably between about 0.01 to 100 mg/kg of body weight per day, and most preferably between about 0.1 to 20 mg/kg/day.
- the most preferred doses will range from about 0.001 to about 10 mg/kg/minute during a constant rate infusion.
- Compounds of this invention may be administered in a single daily dose, or the total daily dosage may be administered in divided doses of two, three, or four times daily.
- Compounds of this invention can be administered in intranasal form via topical use of suitable intranasal vehicles, or via transdermal routes, using transdermal skin patches. When administered in the form of a transdermal delivery system, the dosage administration will, of course, be continuous rather than intermittent throughout the dosage regimen.
- the compounds are typically administered in admixture with suitable pharmaceutical diluents, excipients, or carriers (collectively referred to herein as pharmaceutical carriers) suitably selected with respect to the intended form of administration, that is, oral tablets, capsules, elixirs, syrups and the like, and consistent with conventional pharmaceutical practices.
- suitable pharmaceutical diluents, excipients, or carriers suitably selected with respect to the intended form of administration, that is, oral tablets, capsules, elixirs, syrups and the like, and consistent with conventional pharmaceutical practices.
- the active drug component can be combined with an oral, non-toxic, pharmaceutically acceptable, inert carrier such as lactose, starch, sucrose, glucose, methyl callulose, magnesium stearate, dicalcium phosphate, calcium sulfate, mannitol, sorbitol and the like; for oral administration in liquid form, the oral drug components can be combined with any oral, non-toxic, pharmaceutically acceptable inert carrier such as ethanol, glycerol, water, and the like. Moreover, when desired or necessary, suitable binders, lubricants, disintegrating agents, and coloring agents can also be incorporated into the mixture.
- suitable binders, lubricants, disintegrating agents, and coloring agents can also be incorporated into the mixture.
- Suitable binders include starch, gelatin, natural sugars such as glucose or beta-lactose, corn sweeteners, natural and synthetic gums such as acacia, tragacanth, or sodium alginate, carboxymethylcellulose, polyethylene glycol, waxes, and the like.
- Lubricants used in these dosage forms include sodium oleate, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, sodium chloride, and the like.
- Disintegrators include, without limitation, starch, methyl cellulose, agar, bentonite, xanthan gum, and the like.
- the compounds of the present invention can also be administered in the form of liposome delivery systems, such as small unilamellar vesicles, large unilamellar vesicles, and multilamellar vesicles.
- Liposomes can be formed from a variety of phospholipids, such as cholesterol, stearylamine, or phosphatidylcholines.
- Compounds of the present invention may also be coupled with soluble polymers as targetable drug carriers.
- Such polymers can include polyvinylpyrrolidone, pyran copolymer, polyhydroxypropylmethacrylamide-phenol, polyhydroxyethylaspartamidephenol, or polyethyleneoxide-polylysine substituted with palmitoyl residues.
- the compounds of the present invention may be coupled to a class of biodegradable polymers useful in achieving controlled release of a drug, for example, polylactic acid, polyglycolic acid, copolymers of polylactic and polyglycolic acid, polyepsilon caprolactone, polyhydroxy butyric acid, polyorthoesters, polyacetals, polydihydropyrans, polycyanoacylates, and crosslinked or amphipathic block copolymers of hydrogels.
- a drug for example, polylactic acid, polyglycolic acid, copolymers of polylactic and polyglycolic acid, polyepsilon caprolactone, polyhydroxy butyric acid, polyorthoesters, polyacetals, polydihydropyrans, polycyanoacylates, and crosslinked or amphipathic block copolymers of hydrogels.
- Dosage forms suitable for administration may contain from about 1 milligram to about 1000 milligrams of active ingredient per dosage unit. In these pharmaceutical compositions the active ingredient will ordinarily be present in an amount of about 0.1-95% by weight based on the total weight of the composition.
- Gelatin capsules may contain the active ingredient and powdered carriers, such as lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, and the like. Similar diluents can be used to make compressed tablets. Both tablets and capsules can be manufactured as sustained release products to provide for continuous release of medication over a period of hours. Compressed tablets can be sugar coated or film coated to mask any unpleasant taste and protect the tablet from the atmosphere, or enteric coated for selective disintegration in the gastrointestinal tract.
- Liquid dosage forms for oral administration can contain coloring and flavoring to increase patient acceptance.
- water, a suitable oil, saline, aqueous dextrose (glucose), and related sugar solutions and glycols such as propylene glycol or polyethylene glycols are suitable carriers for parenteral solutions.
- Solutions for parenteral administration preferably contain a water soluble salt of the active ingredient, suitable stabilizing agents, and if necessary, buffer substances.
- Antioxidizing agents such as sodium bisulfite, sodium sulfite, or ascorbic acid, either alone or combined, are suitable stabilizing agents.
- citric acid and its salts and sodium EDTA are also used.
- parenteral solutions can contain preservatives, such as benzalkonium chloride, methyl-or propyl-paraben, and chlorobutanol.
- Suitable pharmaceutical carriers are described in Remington's
- a daily dosage may be about 0.1 to 100 milligrams of the compound of the present invention and about 0.1 to 7.5 milligrams of the second anticoagulant, per kilogram of patient body weight.
- the compounds of this invention generally may be present in an amount of about 5 to 100 milligrams per dosage unit, and the second anti-coagulant in an amount of about 1 to 50 milligrams per dosage unit.
- a daily dosage may be about 0.01 to 25 milligrams of the compound of the present invention and about 50 to 150 milligrams of the anti-platelet agent, preferably about 0.1 to 1 milligrams of the compound of the present invention and about 1 to 3 milligrams of antiplatelet agents, per kilogram of patient body weight.
- a daily dosage may be about 0.1 to 1 milligrams of the compound of the present invention, per kilogram of patient body weight and, in the case of the thrombolytic agents, the usual dosage of the thrombolyic agent when administered alone may be reduced by about 50-80% when administered with a compound of the present invention.
- two or more of the foregoing second therapeutic agents are administered with the compound of the present invention, generally the amount of each component in a typical daily dosage and typical dosage form may be reduced relative to the usual dosage of the agent when administered alone, in view of the additive or synergistic effect of the therapeutic agents when administered in combination.
- the compound of the present invention and a second therapeutic agent are combined in a single dosage unit they are formulated such that although the active ingredients are combined in a single dosage unit, the physical contact between the active ingredients is minimized (that is, reduced).
- one active ingredient may be enteric coated. By enteric coating one of the active ingredients, it is possible not only to minimize the contact between the combined active ingredients, but also, it is possible to control the release of one of these components in the gastrointestinal tract such that one of these components is not released in the stomach but rather is released in the intestines.
- One of the active ingredients may also be coated with a material that affects a sustained-release throughout the gastrointestinal tract and also serves to minimize physical contact between the combined active ingredients.
- the sustained-released component can be additionally enteric coated such that the release of this component occurs only in the intestine.
- Still another approach would involve the formulation of a combination product in which the one component is coated with a sustained and/or enteric release polymer, and the other component is also coated with a polymer such as a low viscosity grade of hydroxypropyl methylcellulose (HPMC) or other appropriate materials as known in the art, in order to further separate the active components.
- HPMC hydroxypropyl methylcellulose
- the polymer coating serves to form an additional barrier to interaction with the other component.
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Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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US12/097,080 US8163749B2 (en) | 2005-12-14 | 2006-12-13 | Six-membered heterocycles useful as serine protease inhibitors |
EP06846583A EP1966141A1 (en) | 2005-12-14 | 2006-12-13 | Six-membered heterocycles useful as serine protease inhibitors |
AU2006325746A AU2006325746A1 (en) | 2005-12-14 | 2006-12-13 | Six-membered heterocycles useful as serine protease inhibitors |
JP2008545948A JP2009519966A (en) | 2005-12-14 | 2006-12-13 | 6-membered heterocycles useful as serine protease inhibitors |
NO20082545A NO20082545L (en) | 2005-12-14 | 2008-05-30 | Six-membered heterocycles useful as serine protease inhibitors |
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US75041605P | 2005-12-14 | 2005-12-14 | |
US60/750,416 | 2005-12-14 |
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PCT/US2006/061973 WO2007070818A1 (en) | 2005-12-14 | 2006-12-13 | Six-membered heterocycles useful as serine protease inhibitors |
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US (1) | US8163749B2 (en) |
EP (1) | EP1966141A1 (en) |
JP (1) | JP2009519966A (en) |
KR (1) | KR20080080173A (en) |
CN (1) | CN101341124A (en) |
AU (1) | AU2006325746A1 (en) |
NO (1) | NO20082545L (en) |
WO (1) | WO2007070818A1 (en) |
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---|---|---|---|---|
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US8598167B1 (en) | 2011-02-28 | 2013-12-03 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
US8691507B2 (en) | 2010-09-10 | 2014-04-08 | Epizyme, Inc. | Inhibitors of human EZH2 and methods of use thereof |
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US8883785B2 (en) | 2010-01-25 | 2014-11-11 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
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US9006242B2 (en) | 2012-10-15 | 2015-04-14 | Epizyme, Inc. | Substituted benzene compounds |
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US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
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WO2016201052A1 (en) * | 2015-06-12 | 2016-12-15 | Global Blood Therapeutics, Inc. | Bridged bicyclic kallikrein inhibitors |
WO2017074833A1 (en) | 2015-10-29 | 2017-05-04 | Merck Sharp & Dohme Corp. | Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use |
WO2017074832A1 (en) | 2015-10-29 | 2017-05-04 | Merck Sharp & Dohme Corp. | FACTOR XIa INHIBITORS |
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US9777001B2 (en) | 2014-01-31 | 2017-10-03 | Bristol-Myers Squibb Company | Macrocycles with aromatic P2′ groups as factor xia inhibitors |
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US10040782B2 (en) | 2013-10-16 | 2018-08-07 | Epizyme, Inc. | Hydrochloride salt form for EZH2 inhibition |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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CA3002560A1 (en) | 2015-10-23 | 2017-04-27 | Array Biopharma, Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases |
PL3442972T3 (en) | 2016-04-15 | 2020-07-27 | Abbvie Inc. | Bromodomain inhibitors |
CN114768045A (en) * | 2022-03-28 | 2022-07-22 | 重庆师范大学 | Hemodialysis tube and antibacterial method thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002042273A2 (en) * | 2000-11-07 | 2002-05-30 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
WO2004014844A2 (en) * | 2002-08-09 | 2004-02-19 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
WO2004019868A2 (en) * | 2002-08-29 | 2004-03-11 | Merck & Co., Inc. | N-biarylmethyl aminocycloalkanecarboxamide derivatives |
WO2005123680A1 (en) * | 2004-06-15 | 2005-12-29 | Bristol-Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6593291B1 (en) | 1997-02-06 | 2003-07-15 | Entremed, Inc. | Compositions and methods of use of ligands that bind components of the blood coagulation/clotting pathway for the treatment of cancer and angiogenic-based disease |
US20040180855A1 (en) | 2003-02-19 | 2004-09-16 | Schumacher William A. | Methods of treating thrombosis with reduced risk of increased bleeding times |
US7138412B2 (en) | 2003-03-11 | 2006-11-21 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives useful as serine protease inhibitors |
US7129264B2 (en) | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
US7417063B2 (en) | 2004-04-13 | 2008-08-26 | Bristol-Myers Squibb Company | Bicyclic heterocycles useful as serine protease inhibitors |
US7453002B2 (en) | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
EP1841504B1 (en) | 2005-01-13 | 2014-11-19 | Bristol-Myers Squibb Company | Substituted biaryl compounds as factor xia inhibitors |
CA2633252A1 (en) | 2005-12-14 | 2007-06-21 | Bristol-Myers Squibb Company | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors |
-
2006
- 2006-12-13 EP EP06846583A patent/EP1966141A1/en not_active Withdrawn
- 2006-12-13 WO PCT/US2006/061973 patent/WO2007070818A1/en active Application Filing
- 2006-12-13 AU AU2006325746A patent/AU2006325746A1/en not_active Abandoned
- 2006-12-13 KR KR1020087016923A patent/KR20080080173A/en not_active Application Discontinuation
- 2006-12-13 CN CNA2006800472580A patent/CN101341124A/en active Pending
- 2006-12-13 JP JP2008545948A patent/JP2009519966A/en active Pending
- 2006-12-13 US US12/097,080 patent/US8163749B2/en active Active
-
2008
- 2008-05-30 NO NO20082545A patent/NO20082545L/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002042273A2 (en) * | 2000-11-07 | 2002-05-30 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
WO2004014844A2 (en) * | 2002-08-09 | 2004-02-19 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
WO2004019868A2 (en) * | 2002-08-29 | 2004-03-11 | Merck & Co., Inc. | N-biarylmethyl aminocycloalkanecarboxamide derivatives |
WO2005123680A1 (en) * | 2004-06-15 | 2005-12-29 | Bristol-Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
Non-Patent Citations (1)
Title |
---|
HOEKSTRA ET AL: "Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure-Activity Studies Leading to the Discovery of RWJ-53308", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 25, 1999, pages 5254 - 5265, XP002142349, ISSN: 0022-2623 * |
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US10144746B2 (en) | 2015-06-12 | 2018-12-04 | Global Blood Therapeutics, Inc. | Bridged bicyclic kallikrein inhibitors |
US9815853B2 (en) | 2015-06-12 | 2017-11-14 | Global Blood Therapeutics, Inc. | Bridged bicyclic kallikrein inhibitors |
WO2016201052A1 (en) * | 2015-06-12 | 2016-12-15 | Global Blood Therapeutics, Inc. | Bridged bicyclic kallikrein inhibitors |
US10160750B2 (en) | 2015-06-19 | 2018-12-25 | Bristol-Myers Squibb Company | Diamide macrocycles as factor XIa inhibitors |
US10676477B2 (en) | 2015-07-29 | 2020-06-09 | Bristol-Myers Squibb Company | Factor XIa macrocycle inhibitors bearing a non-aromatic P2' group |
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WO2017074833A1 (en) | 2015-10-29 | 2017-05-04 | Merck Sharp & Dohme Corp. | Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use |
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CN101341124A (en) | 2009-01-07 |
KR20080080173A (en) | 2008-09-02 |
JP2009519966A (en) | 2009-05-21 |
EP1966141A1 (en) | 2008-09-10 |
AU2006325746A1 (en) | 2007-06-21 |
US20090181983A1 (en) | 2009-07-16 |
US8163749B2 (en) | 2012-04-24 |
NO20082545L (en) | 2008-08-27 |
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