WO2007060741A1 - Méthode d'infiltration de substance et appareil à cet usage - Google Patents

Méthode d'infiltration de substance et appareil à cet usage Download PDF

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Publication number
WO2007060741A1
WO2007060741A1 PCT/JP2005/021778 JP2005021778W WO2007060741A1 WO 2007060741 A1 WO2007060741 A1 WO 2007060741A1 JP 2005021778 W JP2005021778 W JP 2005021778W WO 2007060741 A1 WO2007060741 A1 WO 2007060741A1
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WO
WIPO (PCT)
Prior art keywords
introduction
ultrasonic
current
electrode
active ingredient
Prior art date
Application number
PCT/JP2005/021778
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English (en)
Japanese (ja)
Inventor
Kakuji Tojo
Tetsuo Nishiyama
Original Assignee
Laseine Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laseine Co., Ltd. filed Critical Laseine Co., Ltd.
Priority to PCT/JP2005/021778 priority Critical patent/WO2007060741A1/fr
Publication of WO2007060741A1 publication Critical patent/WO2007060741A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Definitions

  • the present invention relates to a substance permeation method and apparatus, and more particularly to a substance permeation method and apparatus for allowing an active ingredient to penetrate the epidermis by ultrasonic introduction or ion introduction.
  • the transdermal transport of molecules is performed by combining ultrasonic introduction with a physical sensor such as ion introduction. After ultrasonic introduction and ion introduction at the same time, ion introduction is performed. By doing so, the amount of penetration of force lusein is increased. (Page 47: Example 5)
  • Patent Document 3 describes administration of a drug through the epidermis by introduction of ultrasonic waves, and an indication S for applying a physical driving force such as ion introduction after the introduction of ultrasonic waves is made. . (Paragraphs 0045, 0049)
  • Patent Document 4 a cleansing mode (ion derivation) is first performed, and then a notching mode (ion introduction) and ultrasonic introduction are performed simultaneously to infiltrate the medicinal component into the epidermis. (Paragraphs 0018, 0019)
  • Patent Document 5 states that ultrasonic introduction and ion introduction are performed simultaneously to infiltrate the bracentric extract and vitamin C derivative (paragraph 0046), and vitamin C is infiltrated by introducing ultrasound after ion introduction. Become. (0049 paragraph)
  • Patent Document 1 Japanese Patent Publication No. 10-509632
  • Patent Document 2 Japanese Patent Laid-Open No. 2001-259045
  • Patent Document 3 Japanese Translation of Special Publication 2002-500075
  • Patent Document 4 Japanese Unexamined Patent Application Publication No. 2004-201718
  • Patent Document 5 Japanese Patent Laid-Open No. 2005-245521
  • the active ingredient can hardly penetrate the epidermis.
  • the amount of penetration can be increased by increasing the ultrasonic intensity in the introduction of ultrasonic waves.
  • the ultrasonic intensity is increased too much, there is a risk that the epidermis burns or the skin tissue is destroyed, and even if the substance permeation method described in Patent Documents 1 to 5 is used, the active ingredient cannot be sufficiently permeated. I helped.
  • the active ingredient can be permeated into the epidermis by using the substance permeation methods of Patent Documents 1 to 5, most of the permeated active ingredient penetrates into the dermis layer inside the epidermis, and the dermis. Since the capillaries in the layer flow to the whole body, the effect of the active ingredient on the epidermis was not sufficiently obtained.
  • Patent Documents 1 to 5 although the active ingredient can permeate the epidermis, the permeation of the active ingredient cannot be controlled in time, and the active ingredient is permeated only when necessary. I could't do it.
  • the present invention is a substance penetration method and apparatus capable of rapidly penetrating the active ingredient into the epidermis, and a substance capable of obtaining the effect of the active ingredient on the epidermis over a long period of time. It is an object of the present invention to provide a permeation method and apparatus, and a substance permeation method and apparatus capable of permeating an active ingredient in a necessary amount when necessary.
  • the substance permeation method according to claim 1 includes ultrasonic introduction in which an ultrasonic wave is applied to the skin coated with an active ingredient, and an ion for bringing a positive current into contact with the skin coated with the active ingredient. Introducing a substance into the epidermis by introducing the above active ingredient,
  • the substance permeation method according to claim 2 includes ultrasonic introduction in which an ultrasonic wave is applied to the skin coated with an active ingredient, and an ion that causes a positive current to flow through the skin coated with the active ingredient. Introducing a substance into the epidermis by introducing the above active ingredient,
  • the substance permeation method according to claim 3 is the substance permeation method according to claim 2, wherein the ion introduction is performed after introducing the ultrasonic wave and allowing the active ingredient to penetrate the epidermis. And ion derivation alternately.
  • the substance permeation device is an addition to the introduction electrode that is brought into contact with the position where the active ingredient is applied, the vibration element that vibrates the introduction electrode to introduce ultrasonic waves, and the introduction electrode.
  • a material permeation apparatus equipped with a current supply means for introducing ions by flowing a current of
  • the control means vibrates the vibration element under the condition of ultrasonic intensity (Iu) X ultrasonic irradiation time (Dp) ⁇ 20, and after introducing the ultrasonic wave by vibrating the vibration element, the current supply means It is characterized in that ion introduction is performed by operating the.
  • the substance permeation apparatus includes an introduction electrode that is brought into contact with a position where an active ingredient is applied, a vibration element that introduces ultrasonic waves by vibrating the introduction electrode, and the introduction electrode.
  • a current supply means for introducing ions by passing a positive current In the substance permeation apparatus equipped with a current supply means for introducing ions by passing a positive current,
  • the current supply means switches the direction of the current to the introduction electrode and allows a negative current to flow to allow ions to be derived.
  • the control means oscillates the vibration element and introduces ultrasonic waves, then causes the current supply means to flow a positive current through the introduction electrode to introduce ions, and further introduces a negative current to the current supply means. It is characterized by flowing ions through the electrode for ion extraction [0009]
  • the substance osmosis device according to claim 12 is the substance osmosis device according to claim 11, wherein the current supply means is a positive current with respect to the introduction electrode under the control of the control means. It is characterized by flowing negative currents alternately.
  • ion introduction is performed after ultrasonic introduction, and Iu (ultrasound intensity) and Dp (ultrasound irradiation time)
  • Iu ultrasound intensity
  • Dp ultrasound irradiation time
  • the active ingredient that has penetrated into the epidermis by performing ultrasonic introduction and ion introduction is further subjected to ion derivation, and then immediately from the epidermis to the dermis. Can be prevented, and the effect of the active ingredient on the epidermis can be maintained for a long time.
  • the active ingredient that has penetrated into the epidermis by ultrasonic introduction and ion introduction thereafter performs ion introduction, ion derivation, and current interruption of ion introduction.
  • the amount of permeation from the epidermis to the dermis can be controlled in time, and the active ingredient can be permeated as necessary when necessary.
  • FIGS. 1 and 2 show a beauty device 1 as a substance infiltration device used in the substance infiltration method according to the present invention. It penetrates the epidermis to obtain a beauty effect.
  • This cosmetic device 1 is provided with a housing 2 made of resin, a cosmetic electrode 3 as a hemispherical introduction electrode provided on the upper front surface of the housing 2, and provided on both sides of the housing 2.
  • a grasping electrode 4 having a substantially elliptical shape is provided, and four LEDs 5 and three switches 6 are provided below the cosmetic electrode 3.
  • the casing 2 is formed so as to be gripped by the user's hand shown by the imaginary line in FIG. 1, and the conductive gripping electrodes 4 are provided on both side surfaces above the casing 2 for use. Thumbs up And the tip part of the index finger comes into contact.
  • the surface of the resin component having a conductive plating or a metal product can be used.
  • FIG. 3 shows a view of the beauty device 1 cut along III-III in FIG. 1.
  • the casing 2 can be divided into a front case 2a and a back case 2b. Are fixed to each other by screws 7 above both cases 2a and 2b.
  • the cosmetic electrode 3 is conductive and has a substantially hemispherical shape, and protrudes from the upper side of the surface side case 2a to the outside. As the cosmetic electrode 3, a conductive plating is applied to the surface of the grease component. Thing and metal things can be used.
  • a flange 3a protrudes from the bottom surface of the cosmetic electrode 3 in the direction of expanding the diameter.
  • the flange 3a is sandwiched between the surface side case 2a and the ring-shaped attachment member 8 so that the cosmetic electrode 3 is It comes to be fixed to case 2a.
  • a conventionally known vibration element 9 is fixed to the center of the bottom surface of the cosmetic electrode 3, and the vibration of the vibration element 9 propagates to the cosmetic electrode 3 to generate ultrasonic waves from the cosmetic electrode 3.
  • a conventionally known rechargeable battery 10 is provided on the back side case 2b, and the rechargeable battery 10 is connected to a connection port 11 provided at the lower ends of both cases 2a and 2b by a lead wire (not shown). . By inserting a power plug (not shown) into the connection port 11, the rechargeable battery 10 can be charged!
  • a substrate 12 is provided between the front side case 2a and the back side case 2b.
  • the control board 12 vibrates the vibration element 9 and causes a current to flow through the cosmetic electrode 3 and the gripping electrode 4.
  • a positive current flows through the cosmetic electrode 3
  • a negative current flows through the gripping electrode 4.
  • a positive current is applied to the gripping electrode 4.
  • the control board 12 can be operated by the switch 6 described above. By operating the switch 6, the course registered on the control board 12 or the course registered in the control board 12 can be obtained. It is possible to select the ultrasonic intensity of the ultrasonic introduction and the current value of the ion introduction 'voltage value.
  • the control board 12 automatically vibrates the vibration element 9 and supplies current to the cosmetic electrode 3 according to the selected content.
  • the contents of the selected course and information on the ON / OFF of the power supply are displayed on the above LED5, and if necessary, a warning sound is generated by a not-shown speaker power provided in the housing. This prompts the user to touch the gripping electrode 4 during ion introduction.
  • the skin tissue is laminated in the order of surface force in the order of the epidermis layer, the dermis layer, and the subcutaneous tissue.
  • the surface of the epidermis layer has a stratum corneum thickness of 10 to 20 m. Layers are formed, and organs such as capillaries and nerves are developed in the dermis layer.
  • the stratum corneum is formed by stacking 15 to 20 layers of flat corneocytes filled with fibrous protein (keratin). A lamellar structure is formed to fill the space between the corneocytes.
  • the ultrasonic wave disrupts the tissue structure of the epidermis layer by bringing the cosmetic electrode 3 into contact with the surface of the stratum corneum while the vibrating element 9 is vibrated. It has come to promote the penetration of.
  • Iontophoresis is performed by bringing the cosmetic electrode 3 to which a positive current is passed into contact with the surface of the stratum corneum, and bringing the thumb and index finger into contact with the grasping electrode 4 so that the cosmetic electrode 3 and the skin are brought into contact with each other.
  • An electric field due to a potential difference is generated between the tissue and the tissue.
  • ionic substances can penetrate into the stratum corneum by electro repulsion.
  • Vitamin B12 as an active ingredient here is a force that is a non-ionic substance. Can do.
  • the thumb electrode and the index finger are brought into contact with the gripping electrode 4 through which a positive current is passed, and the cosmetic electrode 3 is brought into contact with the surface of the stratum corneum.
  • An electric field due to a potential difference is generated between the skin and the skin tissue.
  • the electric field at this time has a potential gradient opposite to that of the ion introduction described above, and the surface force of the stratum corneum moved by the ion introduction, whereas the solvent moved from the dermis layer to the surface of the stratum corneum. As a result, it is thought that the active ingredient also moves according to the flow.
  • this ion derivation has been used mainly in the field of beauty equipment to obtain a cleansing effect for removing foreign substances in the epidermis.
  • the user preliminarily applies a lotion or gel containing an active ingredient such as vitamin B12 on the part where the cosmetic effect is desired.
  • a lotion or gel containing an active ingredient such as vitamin B12 instead of applying the lotion, it is also possible to cover the portion where the cosmetic effect is desired with a fiber soaked in the lotion.
  • the control board 12 first vibrates the vibration element 9 to generate ultrasonic waves from the beauty electrode 3, The user touches the cosmetic electrode 3 to the position where the lotion is applied and introduces ultrasonic waves.
  • the control board 12 When the ultrasonic introduction is performed for a predetermined time, the control board 12 generates a warning sound from the speaker, stops the ultrasonic irradiation, finishes the ultrasonic introduction, and holds the master finger and the index finger with respect to the user. Prompt to touch electrode 4.
  • control board 12 When the control board 12 detects that the user's thumb and index finger have touched the gripping electrode 4 or when the warning sound is generated and the force is applied for a predetermined time, the control board 12 applies a positive current for cosmetic purposes. Flow through electrode 3, user makes cosmetic electrode 3 Ion introduction is performed in contact with the position where water is applied.
  • the control board 12 When the ion introduction is performed for a predetermined time, the control board 12 generates a warning sound again from the speaker, stops the supply of the positive current to the cosmetic electrode 3, and this time the brass current is used for the gripping. Ion derivation over a specified time by flowing to electrode 4
  • the functions of ultrasonic introduction, ion introduction, and ion derivation are performed under the following conditions.
  • the ultrasonic frequency can actually be set in the range of 5k to 20MHz, but the beauty device of this embodiment can select the ultrasonic frequency of lk to 5MHz by the above switch 6 in particular. It becomes like this.
  • the duty cycle (Duty Cycle) that actually vibrates the vibration element 9 is set in accordance with the ultrasonic intensity as well as the viewpoint power of circuit protection, and the ultrasonic intensity (lu) is It is 5.40 (%) for H, 3.60 (%) for M, and 2.10 (%) for L.
  • the actual ultrasonic irradiation time (Dp) is 1.62 (min) when the ultrasonic intensity (lu) is H, When M is 1.08 (min), when L is 0.54 (min).
  • a positive current is applied to the cosmetic electrode 3 in a current density range of 0.1 to 1.0 mA / cm 2 and a voltage of 3 to 12 V! /.
  • a positive current is passed through the gripping electrode 4 in a current density range of 0.1 to 1.
  • the ultrasonic intensity (I u) and the ultrasonic irradiation time (Dp) can be freely set within the range of the following formula 1.
  • IuX Dp ⁇ 20 '-' (Equation 1)
  • the graph shown in Fig. 5 shows Iu X Dp on the horizontal axis and the penetration rate of active ingredient ((dQZdt) pZ (dQZ dt) c) on the vertical axis.
  • active ingredient ((dQZdt) pZ (dQZ dt) c)
  • an experiment was conducted in which vitamin C penetrates the hairless mouse epidermis at an ultrasonic frequency of 1 ⁇ and an ultrasonic intensity of 4.3 WZcm 2 .
  • the penetration rate of the active ingredient decreases when it exceeds 1100.
  • the reason for this is thought to be that when Iu X Dp exceeds 20, enzyme deactivation occurs in the skin tissue, and the penetration of the active ingredient is hindered.
  • the ultrasonic wave is introduced for a maximum of 71 minutes for ultrasonic intensity (Iu) force 3 ⁇ 4, a maximum of 90 minutes for M, and a maximum of 151 minutes for L. It becomes possible.
  • the active ingredient of the skin lotion can be more efficiently infiltrated than before, and the effect of the active ingredient can be maintained for a long time. It becomes possible.
  • Vitamin B12 with a molecular weight of 1355.38 (is this expression correct?) was used as an active ingredient in skin lotion.
  • This vitamin B12 has water-soluble and nonionic properties.
  • Fig. 7 (a) is a device that measures the amount of vitamin B12 permeation by simple application.
  • Receptor cell 21 is divided into two spaces at the center, and hot water is used to surround receptor cell 21.
  • a water jacket 22 to be circulated and a force are also formed, and each space of the receptor cell 21 is filled with a phosphate buffer L as a receptor.
  • This phosphate buffer L is kept at 37 ° C. by the hot water circulating in the water jacket 22.
  • the epidermis S is set above the receptor cell 21 so that the stratum corneum faces upward, and the surface of the epidermis S is a Hyde mouth gel containing 2% VB12 (hereinafter referred to as drug gel DG). And Hyde Mouth Gel not containing VB12 (hereinafter referred to as “Blank Gel BG”) were applied so as to be located above each space of the receptor cell 21.
  • the experiment shown in Fig. 7 (b) is an apparatus for measuring the amount of vitamin B12 permeation by introduction of ultrasonic waves.
  • the experiment is performed using the receptor cell 21 and the like used in the above experiment.
  • the blank gel BG is filled in one hole of the gel holder, and in this state, the cosmetic electrode 3 of the cosmetic device 1 is brought into contact, and the ultrasonic frequency is set to 300 kHz and the ultrasonic intensity is set to H (ultrasonic wave) Intensity 5.21 WZcm 2 , duty cycle 5.4%) and irradiated with ultrasonic waves for 30 minutes, after which the blank gel BG on the epidermis S was completely removed.
  • H ultrasonic wave
  • ultrasonic pretreatment the operation until the blank gel is removed.
  • the experiment shown in Fig. 7 (c) is an instrument for measuring the amount of penetration of vitamin B12 by iontophoresis.
  • the experiment was performed using the receptor cell 21 used in the above experiment, and the ultrasonic pretreatment was performed.
  • An experiment was conducted for each of the epidermis S and the epidermis S that had been subjected to ultrasonic pretreatment.
  • each of the above drug gel DG and blank gel BG is applied to the epidermis S, electrodes 23 and 24 are brought into contact with each of the drug gel DG and blank gel BG, and the cosmetic electrode 3 of the cosmetic device 1 is connected to the electrode 23. Then, a positive current was applied, and a gripping electrode 4 was connected to the electrode 24 so that a negative current was applied.
  • an experiment on skin S without ultrasonic pretreatment is called an IP experiment
  • an experiment on epidermis S with ultrasonic pretreatment is called an SP + IP experiment.
  • FIG. 8 shows the measurement results of the flux of vitamin B12 (gZ cm 2 Zhour) in each experiment.
  • the power from the beauty device 1 was 1.48 mW.
  • the power was set at 1.8 mW.
  • the SP experiment flux is 12 times that of the Co experiment
  • the IP experiment flux is 21 times that of the Co experiment
  • the SP + IP experiment flux is 217 times that of the Co experiment
  • SP + IP The experimental flux was 22 times that of the SP experiment and 11 times that of the IP experiment.
  • Figure 9 shows the experimental results.
  • the vertical axis shows the amount of penetration of active ingredient (g / cm 2 ) and the horizontal axis shows the elapsed time.
  • It shows the experimental results combining ultrasonic introduction, ion introduction, ion derivation, and IP termination.
  • ion introduction, ion derivation, ion introduction, IP stop ion introduction, ion derivation every hour from the start of the experiment. Switching operation was performed in the order of ion introduction and IP stop.
  • the flux of the active ingredient during ion derivation is about 2.48 ( ⁇ g / cm hour), which is 1Z137 and Co experiment compared to the flux in the SP + IP experiment.
  • the flow rate was 1.6 times higher.
  • the flux of the active ingredient at the time of IP stop is about 18.82 (/ ⁇ 8 ⁇ . ⁇ 2 ⁇ ⁇ :).
  • the permeation amount increased more than the flux at the time of the P experiment.
  • the penetration of the active ingredient of the cosmetic by the beauty device 1 has been described.
  • the medicine can be applied through the epidermis as in the following second embodiment. It can be carried out.
  • the substance permeation apparatus in this example is a substance permeation apparatus having the functions of ultrasonic introduction, ion introduction, and ion derivation, similar to the beauty device 1, and further includes a sensor for measuring the blood concentration of the active ingredient. Prepare.
  • the substance penetration method for infiltrating the active ingredient of this drug is the same as in the case of infiltrating the active ingredient using the cosmetic device 1 described above. After introducing the ultrasonic wave first, ion introduction is performed, and the active ingredient penetrates the epidermis.
  • the active ingredient can rapidly penetrate into the capillaries of the dermis layer, and then the blood concentration of the active ingredient is measured by the sensor.
  • the active ingredient can penetrate into the blood as needed, making it optimal. Drug administration can be performed.
  • vitamin B12 having a molecular weight of 1355.38 has been described as an example of an active ingredient.
  • an active ingredient having a molecular weight of 1000 or less can efficiently penetrate into the epidermis. Even with an active ingredient having a molecular weight of about 10,000, the above effect can be obtained.
  • FIG. 1 is a front view relating to a beauty device used in this example.
  • FIG. 2 is a side view of the beauty device.
  • FIG. 3 is a cross-sectional view taken along line III in FIG.
  • FIG. 5 is a graph showing the relationship between IuX Dp and permeability.
  • FIG. 6 is a table showing the relationship between the ultrasonic intensity output by the beauty device of this example and the ultrasonic irradiation time.
  • FIG. 7 Shows the equipment used in the experiment.
  • (A) shows the Control experiment
  • (b) shows the SP experiment
  • (c) shows the IP experiment.
  • FIG. 8 A table showing the experimental results for the flux of each experiment.
  • FIG. 9 is a table showing experimental results on the amount of penetration and the elapsed time.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Electrotherapy Devices (AREA)
  • Percussion Or Vibration Massage (AREA)

Abstract

L’invention concerne des préparations cosmétiques qui contiennent de la vitamine B12 d’un poids moléculaire de 1355,38 appliquées à l'épiderme. Une électrode cosmétique (3) est mise en contact avec la partie pertinente, et la perfusion ultrasonique s’effectue pendant 30 min. Par la suite, en outre un courant positif est passé par l'électrode cosmétique (3) pour ainsi réaliser l'iontophorèse. En réalisant la perfusion ultrasonique précitée sous une condition d'intensité d'ultrason (Iu) × temps d'irradiation ultrasonique (Dp) ≤ 20, il s’est avéré que la quantité de principe actif ayant infiltré l'épiderme augmente jusqu’à 217 fois celle observée en cas d’une simple application, jusqu’à 18 fois celle observée en cas de perfusion ultrasonique seule, et jusqu’à 12 fois celle observée en cas d'iontophorèse seule. Une infiltration efficace de principes actifs dans l'épiderme peut ainsi être obtenue.
PCT/JP2005/021778 2005-11-28 2005-11-28 Méthode d'infiltration de substance et appareil à cet usage WO2007060741A1 (fr)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009247811A (ja) * 2008-04-10 2009-10-29 Asahi Irika Kk 超音波を用いた経皮浸透具
WO2014190490A1 (fr) * 2013-05-28 2014-12-04 Yao Guangquan Dispositif médical d'administration de médicament
WO2020098027A1 (fr) * 2018-11-14 2020-05-22 深圳美丽策光生物科技有限公司 Instrument de soins de la peau multifonctionnel et procédé de commande
JP7273871B2 (ja) 2016-07-19 2023-05-15 シャープ株式会社 洗浄器
CN117258129A (zh) * 2023-10-31 2023-12-22 深圳市宗匠科技有限公司 促渗控制方法、促渗美容仪及存储介质

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002500075A (ja) * 1998-01-08 2002-01-08 ソントラ メディカル， インコーポレイテッド 超音波伝達で増強される経皮輸送

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002500075A (ja) * 1998-01-08 2002-01-08 ソントラ メディカル， インコーポレイテッド 超音波伝達で増強される経皮輸送

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009247811A (ja) * 2008-04-10 2009-10-29 Asahi Irika Kk 超音波を用いた経皮浸透具
WO2014190490A1 (fr) * 2013-05-28 2014-12-04 Yao Guangquan Dispositif médical d'administration de médicament
JP7273871B2 (ja) 2016-07-19 2023-05-15 シャープ株式会社 洗浄器
WO2020098027A1 (fr) * 2018-11-14 2020-05-22 深圳美丽策光生物科技有限公司 Instrument de soins de la peau multifonctionnel et procédé de commande
CN117258129A (zh) * 2023-10-31 2023-12-22 深圳市宗匠科技有限公司 促渗控制方法、促渗美容仪及存储介质

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