WO2007058878A3 - Mechanisms of osteoinduction by lim mineralization protein-1 (lmp-1) - Google Patents

Mechanisms of osteoinduction by lim mineralization protein-1 (lmp-1) Download PDF

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Publication number
WO2007058878A3
WO2007058878A3 PCT/US2006/043610 US2006043610W WO2007058878A3 WO 2007058878 A3 WO2007058878 A3 WO 2007058878A3 US 2006043610 W US2006043610 W US 2006043610W WO 2007058878 A3 WO2007058878 A3 WO 2007058878A3
Authority
WO
WIPO (PCT)
Prior art keywords
lmp
osteoinduction
mechanisms
lim mineralization
mineralization protein
Prior art date
Application number
PCT/US2006/043610
Other languages
French (fr)
Other versions
WO2007058878A2 (en
Inventor
Jeffrey C Marx
William F Mckay
Scott D Boden
Sreedhara Sangadala
Original Assignee
Warsaw Orthopedic Inc
Univ Emory
Jeffrey C Marx
William F Mckay
Scott D Boden
Sreedhara Sangadala
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warsaw Orthopedic Inc, Univ Emory, Jeffrey C Marx, William F Mckay, Scott D Boden, Sreedhara Sangadala filed Critical Warsaw Orthopedic Inc
Publication of WO2007058878A2 publication Critical patent/WO2007058878A2/en
Publication of WO2007058878A3 publication Critical patent/WO2007058878A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/9015—Ligases (6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Abstract

The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to Combinatorial therapeutic strategies including small molecules and peptide mimics of LIM mineralization proteins, particularly LMP-I, to overcome the dose-related translational barriers for BMP-2 therapeutics.
PCT/US2006/043610 2005-11-10 2006-11-09 Mechanisms of osteoinduction by lim mineralization protein-1 (lmp-1) WO2007058878A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73619105P 2005-11-10 2005-11-10
US60/736,191 2005-11-10

Publications (2)

Publication Number Publication Date
WO2007058878A2 WO2007058878A2 (en) 2007-05-24
WO2007058878A3 true WO2007058878A3 (en) 2008-09-25

Family

ID=38049142

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/043610 WO2007058878A2 (en) 2005-11-10 2006-11-09 Mechanisms of osteoinduction by lim mineralization protein-1 (lmp-1)

Country Status (1)

Country Link
WO (1) WO2007058878A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138473A1 (en) * 1999-08-13 2003-07-24 Antony Koblish Composite shaped bodies and methods for their production and use
US20040034428A1 (en) * 2000-10-24 2004-02-19 Mckay William F Spinal fusion methods and devices

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138473A1 (en) * 1999-08-13 2003-07-24 Antony Koblish Composite shaped bodies and methods for their production and use
US20040034428A1 (en) * 2000-10-24 2004-02-19 Mckay William F Spinal fusion methods and devices

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BODEN S.D. ET AL.: "LMP-1, a LIM-Domain Protein, Mediates BMP-6 Effects on Bone Formation", ENDOCRINOLOGY, vol. 139, no. 12, 1998, pages 5125 - 5134, XP002930583 *
GROENEVELD E.H.J. ET AL.: "Bone morphogenetic proteins in human bone regeneration", EUR. J. ENDOCRINOL., vol. 142, 2000, pages 9 - 21, XP055144981, DOI: doi:10.1530/eje.0.1420009 *

Also Published As

Publication number Publication date
WO2007058878A2 (en) 2007-05-24

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