WO2007045686A3 - Intermediate and process of preparation of ecteinascidin such as ecteinascidines-583, 597 using such intermediate - Google Patents
Intermediate and process of preparation of ecteinascidin such as ecteinascidines-583, 597 using such intermediate Download PDFInfo
- Publication number
- WO2007045686A3 WO2007045686A3 PCT/EP2006/067611 EP2006067611W WO2007045686A3 WO 2007045686 A3 WO2007045686 A3 WO 2007045686A3 EP 2006067611 W EP2006067611 W EP 2006067611W WO 2007045686 A3 WO2007045686 A3 WO 2007045686A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- ecteinascidin
- preparation
- represent
- alkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 title abstract 2
- 229960000977 trabectedin Drugs 0.000 title abstract 2
- -1 ecteinascidines-583 Chemical compound 0.000 title 1
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
- XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 abstract 1
- YMAUZYADYYYPHZ-UHFFFAOYSA-N Ecteinascidin 770 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(C#N)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C YMAUZYADYYYPHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- BGFXHQYUWCGGLL-QWIBJBKUSA-N ecteinascidin 770 Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](C#N)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 BGFXHQYUWCGGLL-QWIBJBKUSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002626595A CA2626595A1 (en) | 2005-10-20 | 2006-10-20 | Intermediate and process of preparation of ecteinascidin such as ecteinascidines-583, 597 using such intermediate |
EP06829917A EP1937689B1 (en) | 2005-10-20 | 2006-10-20 | Intermediate and process of preparation of ecteinascidins such as ecteinascidins 583 and 597 using such intermediate |
JP2008536058A JP2009512662A (en) | 2005-10-20 | 2006-10-20 | Intermediates and methods for preparing echinasaidins such as echinasaidin 583, 597 using such intermediates |
AT06829917T ATE554093T1 (en) | 2005-10-20 | 2006-10-20 | INTERMEDIATE PRODUCT AND METHOD FOR PRODUCING ECTEINASCIDINS SUCH AS ECTEINASCIDIN 583 AND 597 USING SUCH INTERMEDIATE |
US12/083,740 US8058435B2 (en) | 2005-10-20 | 2006-10-20 | Intermediate and process of preparation of ecteinascidin such as ecteinascidines-583,597 using such intermediate |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72829505P | 2005-10-20 | 2005-10-20 | |
EP05292203.6 | 2005-10-20 | ||
EP05292203A EP1792904A1 (en) | 2005-10-20 | 2005-10-20 | Intermediate and process of preparation of ecteinascidin using such intermediate |
US60/728,295 | 2005-10-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007045686A2 WO2007045686A2 (en) | 2007-04-26 |
WO2007045686A3 true WO2007045686A3 (en) | 2007-07-12 |
Family
ID=37899253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/067611 WO2007045686A2 (en) | 2005-10-20 | 2006-10-20 | Intermediate and process of preparation of ecteinascidin such as ecteinascidines-583, 597 using such intermediate |
Country Status (6)
Country | Link |
---|---|
US (1) | US8058435B2 (en) |
EP (2) | EP1792904A1 (en) |
JP (1) | JP2009512662A (en) |
AT (1) | ATE554093T1 (en) |
CA (1) | CA2626595A1 (en) |
WO (1) | WO2007045686A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9090542B2 (en) * | 2009-11-11 | 2015-07-28 | University Of Georgia Research Foundation, Inc. | Methods for labeling a substrate using a hetero-diels-alder reaction |
US20110108411A1 (en) * | 2009-11-11 | 2011-05-12 | Popik Vladimir V | Methods for labeling a substrate using a hetero-diels-alder reaction |
ES2534331T3 (en) | 2010-05-25 | 2015-04-21 | Pharma Mar S.A. | Synthetic process for the production of ecteinascidin compounds and intermediates |
CN103304478B (en) * | 2013-06-28 | 2016-04-20 | 四川大学 | Alkaloidal intermediate of one class synthesis renieramycins type and preparation method thereof |
CN103709101B (en) * | 2013-12-19 | 2016-06-29 | 四川大学 | Synthetic intermediate of one class renieramycin G and preparation method thereof |
CN107739387B (en) * | 2017-10-16 | 2020-01-03 | 上海皓元生物医药科技有限公司 | Method for preparing key intermediate compound of trabectedin |
CN109912629B (en) | 2017-12-13 | 2021-12-24 | 浙江中科创越药业有限公司 | Preparation of Natural product Trabectedin |
CN108276408B (en) * | 2018-04-19 | 2020-09-29 | 上海皓元医药股份有限公司 | Intermediate of trabectedin, preparation method and application thereof |
CN111518110B (en) | 2019-02-01 | 2023-11-03 | 博瑞生物医药(苏州)股份有限公司 | Preparation method of ecteinascidin compound and intermediate thereof |
CN112745327B (en) * | 2019-10-30 | 2023-08-25 | 南通诺泰生物医药技术有限公司 | Preparation method of koji Bei Ti intermediate compound |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1471068A1 (en) * | 2002-01-29 | 2004-10-27 | Japan Science and Technology Agency | Process for total synthesis of ecteinascidins and intermediates therefor |
-
2005
- 2005-10-20 EP EP05292203A patent/EP1792904A1/en not_active Withdrawn
-
2006
- 2006-10-20 WO PCT/EP2006/067611 patent/WO2007045686A2/en active Application Filing
- 2006-10-20 US US12/083,740 patent/US8058435B2/en not_active Expired - Fee Related
- 2006-10-20 CA CA002626595A patent/CA2626595A1/en not_active Abandoned
- 2006-10-20 JP JP2008536058A patent/JP2009512662A/en active Pending
- 2006-10-20 AT AT06829917T patent/ATE554093T1/en active
- 2006-10-20 EP EP06829917A patent/EP1937689B1/en not_active Not-in-force
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1471068A1 (en) * | 2002-01-29 | 2004-10-27 | Japan Science and Technology Agency | Process for total synthesis of ecteinascidins and intermediates therefor |
Non-Patent Citations (2)
Title |
---|
CHEN J ET AL: "Total synthesis of ecteinascidin 743", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 11 JAN 2006 UNITED STATES, vol. 128, no. 1, 11 January 2006 (2006-01-11), pages 87 - 89, XP002429041, ISSN: 0002-7863 * |
ENDO ATSUSHI ET AL: "Total synthesis of ecteinascidin 743", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 124, no. 23, 17 May 2002 (2002-05-17), pages 6552 - 6554, XP002961311, ISSN: 0002-7863 * |
Also Published As
Publication number | Publication date |
---|---|
CA2626595A1 (en) | 2007-04-26 |
US20090171080A1 (en) | 2009-07-02 |
EP1792904A1 (en) | 2007-06-06 |
EP1937689B1 (en) | 2012-04-18 |
US8058435B2 (en) | 2011-11-15 |
JP2009512662A (en) | 2009-03-26 |
WO2007045686A2 (en) | 2007-04-26 |
EP1937689A2 (en) | 2008-07-02 |
ATE554093T1 (en) | 2012-05-15 |
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