WO2007024976A3 - Virus coat protein/receptor chimeras and methods of use - Google Patents

Virus coat protein/receptor chimeras and methods of use Download PDF

Info

Publication number
WO2007024976A3
WO2007024976A3 PCT/US2006/032957 US2006032957W WO2007024976A3 WO 2007024976 A3 WO2007024976 A3 WO 2007024976A3 US 2006032957 W US2006032957 W US 2006032957W WO 2007024976 A3 WO2007024976 A3 WO 2007024976A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
virus
chimeric
coat protein
chimeric molecules
Prior art date
Application number
PCT/US2006/032957
Other languages
French (fr)
Other versions
WO2007024976A2 (en
Inventor
Anthony L Devico
Timothy Fouts
Robert G Tusken
Original Assignee
Univ Maryland Biotech Inst
Anthony L Devico
Timothy Fouts
Robert G Tusken
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland Biotech Inst, Anthony L Devico, Timothy Fouts, Robert G Tusken filed Critical Univ Maryland Biotech Inst
Publication of WO2007024976A2 publication Critical patent/WO2007024976A2/en
Publication of WO2007024976A3 publication Critical patent/WO2007024976A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co- receptor. Such chimeric molecules therefore exhibit functional properties characteristic of a receptor-coat protein complex and are useful as agents that inhibit virus infection of cells due to occupancy of a co-receptor present on the cell. In particular aspects, the chimeric polypeptide includes an immunodeficiency virus envelope polypeptide, such as that of HIV, SIV, FIV, FeLV, FPV and herpes virus. Receptor sequences suitable for use in a chimeric polypeptide include, for example, CD4 receptors, fragments and mimetic thereof. DNA vaccines comprising nucleotide sequences encoding for such chimeric molecules is another aspect of the present invention.
PCT/US2006/032957 2005-08-23 2006-08-23 Virus coat protein/receptor chimeras and methods of use WO2007024976A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71064605P 2005-08-23 2005-08-23
US60/710,646 2005-08-23

Publications (2)

Publication Number Publication Date
WO2007024976A2 WO2007024976A2 (en) 2007-03-01
WO2007024976A3 true WO2007024976A3 (en) 2009-04-09

Family

ID=37772338

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/032957 WO2007024976A2 (en) 2005-08-23 2006-08-23 Virus coat protein/receptor chimeras and methods of use

Country Status (1)

Country Link
WO (1) WO2007024976A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2324755B1 (en) * 2007-04-04 2010-05-31 Consejo Superior De Investigaciones Cientificas (Csic) PROTEIN GP120 POLYPEPTIDE ABLE TO INHIBIT THE VITAL CYCLE OF AIDS VIRUS.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908612B2 (en) * 1999-10-08 2005-06-21 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
US7311920B1 (en) * 1999-10-08 2007-12-25 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908612B2 (en) * 1999-10-08 2005-06-21 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
US7311920B1 (en) * 1999-10-08 2007-12-25 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZAGHOUANI ET AL.: "Induction of antibodies to the human immunodeficiency virus type 1 by immunization of baboons with immunoglobulin molecules carrying the principal.neutralizing determinant of the envelope protein", PROC. NATL. ACAD. SCI. U S A., vol. 92, January 1995 (1995-01-01), pages 631 - 635, XP002017328 *

Also Published As

Publication number Publication date
WO2007024976A2 (en) 2007-03-01

Similar Documents

Publication Publication Date Title
WO2003016333A3 (en) Virus coat protein/receptor chimeras and methods of use
WO2010022740A3 (en) Hiv-1 envelope polypeptides for hiv vaccine
WO2007062656A3 (en) A nucleotide vaccine
JP2015532654A5 (en)
JP2010529860A5 (en)
JP2019501882A5 (en)
WO2010003065A3 (en) Axmi-il 5, axmi-113, axmi-005, axmi-163 and axmi-184 : vip3a insecticidal proteins from bacillus thuringiensis and methods for their use
JP2018506983A5 (en)
EP2264152A3 (en) Fusion constructs and use of same to produce antibodies with increased FC receptor binding affinity and effector function
WO2008005880A3 (en) Antibodies for norovirus
WO2007030803A3 (en) Method for preparing trimeric proteins
WO2021198706A3 (en) Coronavirus vaccines
EP2339010A3 (en) Lentiviral vector particles resistant to complement inactivation
WO2007024976A3 (en) Virus coat protein/receptor chimeras and methods of use
WO2014043220A2 (en) Hiv-1 envelope proteins and fragments thereof that possess epitopes recognized by broadly neutralizing antibodies
WO2003066810A3 (en) Recombinant bovine immunodeficiency virus based gene transfer system
CN106755109A (en) A kind of slow virus carrier for expressing people's CD19 and CD20 Chimeric antigen receptor gene
WO2004029071A3 (en) Mage-c2 antigenic peptides and uses thereof
WO2023280220A9 (en) S protein variant of coronavirus and use thereof
WO2007108829A3 (en) Tuberculosis nucleic acids, polypeptides and immunogenic compositions
US20200325241A1 (en) Novel chimeric antigen receptors and libraries
WO2006060484A3 (en) Tuberculosis nucleic acids, polypeptides and immunogenic compositions
WO2017194903A3 (en) Viral particle for rna transfer, especially into cells involved in immmune response
WO2007127290A3 (en) Method for producing viral vaccine and therapeutic peptide antigens
EP1570051A4 (en) Genetic constructs and compositions comprising rre and cte and uses thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06802190

Country of ref document: EP

Kind code of ref document: A2