WO2007017779A2 - Electric impedance imaging system - Google Patents
Electric impedance imaging system Download PDFInfo
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- WO2007017779A2 WO2007017779A2 PCT/IB2006/052501 IB2006052501W WO2007017779A2 WO 2007017779 A2 WO2007017779 A2 WO 2007017779A2 IB 2006052501 W IB2006052501 W IB 2006052501W WO 2007017779 A2 WO2007017779 A2 WO 2007017779A2
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- field strength
- magnetic
- distribution
- electric
- strength distribution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0536—Impedance imaging, e.g. by tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives
Definitions
- the invention pertains to an electric impedance imaging system to explore the electrical conductivity and permittivity distribution of an object.
- Such an electric impedance imaging system is known from the US patent application US2003/0160622.
- This known electric impedance imaging system concerns an apparatus that utilises an array of RF probes to measure along multiple signal channels the non-resonant thermal noise, which is produced in a sample. From this measurement the non-resonant thermal noise correlation is derived.
- the detected noise correlation is a function of the spatial overlap of the electro-magnetic fields of the RF probes and the spatial distribution of the conductivity of the sample, i.e. an object to be examined.
- the noise correlation between the respective channels (j and k) is equal to ⁇ ( ⁇ )E 7 (r)R k ⁇ r) ⁇ V , where E, is the electric field strength phasor for channel i and ⁇ is the electrical conductivity distribution.
- the electrical conductivity distribution is obtained by way of an inverse problem approach that involves a matrix- inversion or back-projection.
- the known electric impedance imaging system has the function of electrical impedance tomography ( ⁇ IT).
- the ⁇ IT techniques involves generating an electrical current distribution in the object, either through direct contact or inductive coupling and then measuring this distribution through an array of detectors designed to measure either current or voltage. These measurements are then used to calculate an impedance map.
- An aim of the present invention is to provide an electric impedance imaging system which relative to the known electric impedance imaging system has an improved spatial resolution for the electrical conductivity and permittivity distribution.
- the electrical conductivity and permittivity distribution is obtained in a more direct way as compared to how the known electric impedance imaging system operates.
- no inverse problem needs to be solved and accordingly there does not occur a problem related to the inverse problem being ill-posed.
- the known electrical impedance tomography is prone to problems being ill-posed since the spatial frequencies of the electric field distributions are generally much lower than the spatial frequencies of the electrical impedance distribution
- the computational effort that the electric impedance imaging system of the invention requires is less, because the electric impedance imaging system of the invention requires differentiation that is mathematically less complex than the matrix inversion or back-projection that the known electric impedance imaging system uses.
- the aspect of ill-position is avoided.
- the electrical impedance imaging system is able to efficiently handle a large amount of data.
- the computation of the electrical conductivity and permittivity is made on a pixel- by-pixel basis.
- the electric impedance imaging system is for example employed to explore the electrical permittivity distribution of a patient to be examined.
- different biological tissues appear to have different values of the electrical permittivity, so that different tissues can be distinguished on the basis of their values of the electrical permittivity.
- the goniometric function is the sine function, since at zero flip angle, zero signal is obtained.
- the respective excitation and receive circular components of the magnetic induction field strength can be accurately obtained from magnetic resonance signal acquisitions at respective different flip angles associated with the electro-magnetic excitation field applied in the individual series of acquisitions.
- the electro-magnetic excitation field causes a precession of spins in the object around an axis along the direction of a main magnetic field that is applied by the electric impedance imaging system.
- the precession occurs in that the spins rotate at an angle, i.e. the flip angle around the direction of the main magnetic field.
- the respective circularly polarised components of the magnetic induction field strength are derived on the basis of fitting the signal levels of the acquired magnetic resonance signals to the goniometric function dependence.
- This iterative approach is initialised on the basis of a first estimate of the electric field strength distribution that is made on the basis of (i) the geometry of the RF transmit antennae system that is employed to generate the excitation electro-magnetic field, (ii) the electric voltages applied to various elements (e.g. coils) of the RF transmit antennae system, (iii) the size and shape of the object to be examined and (iv) a coarse estimate of the electrical conductivity and permittivity of the object to be examined. On the basis of this initialisation there is computed a better, more accurate, estimate of the electrical conductivity and permittivity distribution.
- RF receive antennae are employed that have complementary spatial sensitivity profiles. This enables to avoids spatial regions where the total electrical field strength is close to zero. This avoids that the computation of the electrical permittivity distribution requires division by small numbers, which would lead to numerical instability.
- an image e.g. in the form of a volumetric dataset or a tomographic, cross-sectional tomographic image is reconstructed from the electrical permittivity distribution.
- an image that represents the electrical permittivity distribution is formed that shows differences in e.g. tissue type that are represented by the differences in electrical permittivity value.
- tissue types that are not distinguished by conventional diagnostic imaging modalities, such as magnetic resonance imaging, x-ray imaging, ultra-sound imaging, nuclear medicine etc. are now seen as different by the electric impedance imaging system of the invention.
- Figure 1 shows diagrammatically an electric impedance imaging system in the form of a magnetic resonance imaging system that is adapted to carry out the function of electrical impedance imaging
- Figure 2 shows a flow chart for Electrical Conductivity Imaging
- Figure 3 shows the results of a demonstration of the basic numerical feasibility of the approach of the invention.
- FIG. 1 shows diagrammatically an electric impedance imaging system in the form of a magnetic resonance imaging system that is adapted to carry out the function of electrical impedance imaging.
- the magnetic resonance imaging system includes a set of main coils 10 whereby the steady, uniform magnetic field is generated.
- the main coils are constructed, for example in such a manner that they enclose a tunnel- shaped examination space.
- the patient to be examined is placed on a patient carrier which is slid into this tunnel- shaped examination space.
- the magnetic resonance imaging system also includes a number of gradient coils 11, 12 whereby magnetic fields exhibiting spatial variations, notably in the form of temporary gradients in individual directions, are generated so as to be superposed on the uniform magnetic field.
- the gradient coils 11, 12 are connected to a controllable power supply unit 21.
- the gradient coils 11, 12 are energised by application of an electric current by means of the power supply unit 21 ; to this end the power supply unit is fitted with electronic gradient amplification circuit that applies the electric current to the gradient coils so as to generate gradient pulses (also termed 'gradient waveforms') of appropriate temporal shape.
- the strength, direction and duration of the gradients are controlled by control of the power supply unit.
- the magnetic resonance imaging system also includes transmission and receiving coils 13, 16 for generating the RF excitation pulses and for picking up the magnetic resonance signals, respectively.
- the transmission coil 13 is preferably constructed as a body coil 13 whereby (a part of) the object to be examined can be enclosed.
- the body coil is usually arranged in the magnetic resonance imaging system in such a manner that the patient 30 to be examined is enclosed by the body coil 13 when he or she is arranged in the magnetic resonance imaging system.
- the body coil 13 acts as a transmission antenna for the transmission of the RF excitation pulses and RF refocusing pulses.
- the body coil 13 involves a spatially uniform intensity distribution of the transmitted RF pulses (RFS).
- the same coil or antenna is usually used alternately as the transmission coil and the receiving coil.
- the transmission and receiving coil is usually shaped as a coil, but other geometries where the transmission and receiving coil acts as a transmission and receiving antenna for RF electromagnetic signals are also feasible.
- the transmission and receiving coil 13 is connected to an electronic transmission and receiving circuit 15.
- receiving and/or transmission coils 16 can be used as receiving and/or transmission coils. Such surface coils have a high sensitivity in a comparatively small volume.
- the receiving coils such as the surface coils, are connected to a demodulator 24 and the received magnetic resonance signals (MS) are demodulated by means of the demodulator 24.
- the demodulated magnetic resonance signals (DMS) are applied to a reconstruction unit.
- the receiving coil is connected to a preamplifier 23.
- the preamplifier 23 amplifies the RF resonance signal (MS) received by the receiving coil 16 and the amplified RF resonance signal is applied to a demodulator 24.
- the demodulator 24 demodulates the amplified RF resonance signal.
- the demodulated resonance signal contains the actual information concerning the local spin densities in the part of the object to be imaged.
- the transmission and receiving circuit 15 is connected to a modulator 22.
- the modulator 22 and the transmission and receiving circuit 15 activate the transmission coil 13 so as to transmit the RF excitation and refocusing pulses.
- the reconstruction unit derives one or more image signals from the demodulated magnetic resonance signals (DMS), which image signals represent the image information of the imaged part of the object to be examined.
- the reconstruction unit 25 in practice is constructed preferably as a digital image processing unit 25 which is programmed so as to derive from the demodulated magnetic resonance signals the image signals which represent the image information of the part of the object to be imaged.
- the reconstructor is also arranged to reconstruct volumetric datasets or tomographic cross sectional images from the electrical permittivity distribution.
- the measurement instead of the noise correlations between different coil measurements is employed of the magnetic induction field (H field) of the coils involved.
- the measured H field might have the same spatial resolution as standard MR images, i.e. typically 0.5-1.0 mm, and so do the derived conductivity/permittivity images.
- both the electric conductivity and the permittivity can be derived within the current approach in opposite to "noise tomography" [3], where only the electric conductivity can be derived.
- the proposed invention provides the possibility to estimate the local SAR via
- VxH(F) i ⁇ (r)E(r) (1) with H the magnetic field strength, E the electric field, ⁇ the Larmor frequency, and ⁇ the permittivity.
- the underlines denote complex variables. Eq. (1) can be solved for the unknown ⁇ by regarding only the z-component
- H x and H y can be measured via MRI, and E 2 has to be estimated via simulations.
- the real and imaginary part of ⁇ can be identified with the (non-complex) permittivity ⁇ and the electric conductivity ⁇ , respectively.
- VxH(r,t) j + d t D(r,t) , (3) withy denoting the current density and D the electric displacement field.
- Eq. (1) can be solved for the unknown ⁇ by regarding the z-component
- Eq. (2) can also be formulated for the x- or y-component, however, the occurring H 2 cannot be measured within MRI (assuming B 0 in z-direction).
- Eq. (2') can be replaced by
- N> ⁇ coils it is easier to avoid regions with E tot close to zero, which would lead to noise amplification in the resulting images.
- more than one combination of coils can be used to measure at least twice and solve simultaneously the same conductivity and permittivity distribution. Determination of H field
- the spatial transmit sensitivity distribution of an RF coil is given by the H component circularly polarized in one direction (which might be defined as the "positive" direction) [4] If the static magnetic field has a negative z-direction, the transmit component is given by
- the spatial receive sensitivity distribution of an RF coil is given by the H component circularly polarized in the opposite direction than in the transmit case (i.e. the "negative" direction) [4]
- the transmit and receive sensitivities can be determined, e.g., using the relation [4]
- S is the image signal intensity and const is a system dependent constant.
- H + and H can be obtained by acquiring a series of images with different flip angles and fitting a sinus in each pixel according to Eq. (9).
- Using a quadrature body coil it might be a good approximation to set H to zero, since this coil is designed to produce only one direction of the circularly polarized field.
- An alternative method is to rotate the patient, i.e., to measure him a second time placing feet first instead head first.
- the coil is rotated, which should be possible in case of using a head or surface coil. It would also be sufficient to switch the main field, which is, of course, out of the scope for today's high field systems, but might be realized with a low field system.
- the obtained spatial resolution should be of the order of the spatial resolution of the measured H field components. This seems to be the main advantage compared with noise tomography [3], where the spatial resolution is limited by the smoothness of the spatial ⁇ field distribution.
- Another advantage of the current approach is the possibility to directly derive the permittivity of the tissue.
- a third difference is given by the required mathematics.
- Noise tomography defines an inverse problem, which can be solved, e.g., via matrix inversion or back-projection.
- the presented approach replaces the inverse problem by a differentiation, which is also a non-trivial task. However, there is hope that this differentiation might be easier to handle than the inverse problem of the noise tomography.
- Eq. (2) is applicable for a single slice.
- a 3D volume is required for the simulation of the E field.
- a 3D acquisition of the H field is preferred to support the E field model.
- ⁇ and ⁇ are assumed to be scalar, i.e., isotropic.
- ⁇ and ⁇ can be tensors, i.e., ⁇ and ⁇ might differ for different spatial directions.
- Different directions of ⁇ and ⁇ can be measured rotating the Bo field relative to the patient. This can be done, e.g., by tilting the patient on the side, or by measuring the patient in different MR systems, e.g., a standard cylindrical system with Bo oriented parallel to the patient's longitudinal axis, and an open MR system with Bo oriented perpendicular to the patient's longitudinal axis.
- Electric conductivity imaging might result in a new modality of medical imaging and many applications can be imagined. For instance, it could be used to distinguish between tumours and healthy tissue [5] or between necrotic and vital tissue after a myocardial infarction. It might also be used to support the characterization of brain tissue in connection with stroke or cerebral haemorrhage. Another application might be given by improved RF ablation planning. The method might also be applied in non-medical areas, e.g., contact-less material testing, as long as the material is suitable for MR. References
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Abstract
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008525672A JP5203199B2 (en) | 2005-08-08 | 2006-07-21 | Electrical impedance imaging system |
CN200680029153.2A CN101237812B (en) | 2005-08-08 | 2006-07-21 | Electric impedance imaging system |
EP06780158.9A EP1915089B1 (en) | 2005-08-08 | 2006-07-21 | Electric impedance imaging system, method, and computer program |
BRPI0614140-4A BRPI0614140A2 (en) | 2005-08-08 | 2006-07-21 | electrical impedance imaging system and method and computer program for exploiting an electrical permittivity distribution of the object |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05107280 | 2005-08-08 | ||
EP05107280.9 | 2005-08-08 |
Publications (2)
Publication Number | Publication Date |
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WO2007017779A2 true WO2007017779A2 (en) | 2007-02-15 |
WO2007017779A3 WO2007017779A3 (en) | 2007-10-11 |
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PCT/IB2006/052501 WO2007017779A2 (en) | 2005-08-08 | 2006-07-21 | Electric impedance imaging system |
Country Status (5)
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EP (1) | EP1915089B1 (en) |
JP (1) | JP5203199B2 (en) |
CN (1) | CN101237812B (en) |
BR (1) | BRPI0614140A2 (en) |
WO (1) | WO2007017779A2 (en) |
Cited By (17)
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WO2007098190A2 (en) * | 2006-02-21 | 2007-08-30 | Beth Israel Deaconess Medical Center, Inc. | Magnetic resonance imaging and radio frequency impedance mapping methods and apparatus |
WO2007127581A1 (en) * | 2006-04-24 | 2007-11-08 | Koninklijke Philips Electronics, N.V. | Shimming of electric field for electric properties tomography |
WO2009118688A1 (en) * | 2008-03-26 | 2009-10-01 | Koninklijke Philips Electronics N.V. | Determination of local sar in vivo and electrical conductivity mapping |
WO2011015983A1 (en) | 2009-08-07 | 2011-02-10 | Koninklijke Philips Electronics N.V. | Apparatus and method for determining at least one electromagnetic quantity |
WO2011080700A1 (en) | 2009-12-31 | 2011-07-07 | Koninklijke Philips Electronics N.V. | Method for calculating local specific energy absorption rate (sar) in nuclear magnetic resonance |
WO2011086512A1 (en) | 2010-01-18 | 2011-07-21 | Koninklijke Philips Electronics N.V. | Electric properties tomography imaging method and system |
CN102397056A (en) * | 2010-09-07 | 2012-04-04 | 华东师范大学 | Method for performing microwave near-field tumor imaging detection by using radial iteration algorithm |
CN103006185A (en) * | 2012-12-19 | 2013-04-03 | 中国人民解放军第四军医大学 | Device and method for non-contact magnetic induction impedance plane projection imaging |
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EP2624004A1 (en) | 2012-02-06 | 2013-08-07 | Koninklijke Philips Electronics N.V. | Temperature determination using magnetic resonance B1 field mapping |
US8942931B2 (en) | 2011-04-20 | 2015-01-27 | General Electric Company | System and method for determining electrical properties using magnetic resonance imaging |
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- 2006-07-21 JP JP2008525672A patent/JP5203199B2/en active Active
- 2006-07-21 EP EP06780158.9A patent/EP1915089B1/en active Active
- 2006-07-21 WO PCT/IB2006/052501 patent/WO2007017779A2/en active Application Filing
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WO2023194217A1 (en) * | 2022-04-06 | 2023-10-12 | Universite De Lorraine | Estimating a distribution of conductivity over a portion of a tissue of a body |
CN117547242A (en) * | 2024-01-12 | 2024-02-13 | 杭州永川科技有限公司 | Magnetic induction tomography apparatus |
CN117547242B (en) * | 2024-01-12 | 2024-05-14 | 杭州永川科技有限公司 | Magnetic induction tomography apparatus |
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BRPI0614140A2 (en) | 2012-05-22 |
WO2007017779A3 (en) | 2007-10-11 |
JP2009504224A (en) | 2009-02-05 |
JP5203199B2 (en) | 2013-06-05 |
EP1915089B1 (en) | 2013-04-10 |
CN101237812B (en) | 2012-04-18 |
CN101237812A (en) | 2008-08-06 |
EP1915089A2 (en) | 2008-04-30 |
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