WO2007014290A2 - Fungicidal carboxamides - Google Patents
Fungicidal carboxamides Download PDFInfo
- Publication number
- WO2007014290A2 WO2007014290A2 PCT/US2006/029175 US2006029175W WO2007014290A2 WO 2007014290 A2 WO2007014290 A2 WO 2007014290A2 US 2006029175 W US2006029175 W US 2006029175W WO 2007014290 A2 WO2007014290 A2 WO 2007014290A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methyl
- trifluoromethyl
- pyrazol
- compound
- alkyl
- Prior art date
Links
- 230000000855 fungicidal effect Effects 0.000 title claims description 20
- 150000003857 carboxamides Chemical class 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 457
- 239000000203 mixture Substances 0.000 claims abstract description 128
- 238000000034 method Methods 0.000 claims abstract description 44
- 150000003839 salts Chemical class 0.000 claims abstract description 22
- 239000000417 fungicide Substances 0.000 claims abstract description 9
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims abstract description 8
- 201000010099 disease Diseases 0.000 claims abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 8
- 244000000004 fungal plant pathogen Species 0.000 claims abstract description 7
- -1 hydroxy, amino Chemical group 0.000 claims description 1867
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 145
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 74
- 229910052736 halogen Inorganic materials 0.000 claims description 71
- 150000002367 halogens Chemical class 0.000 claims description 71
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 59
- 239000007787 solid Substances 0.000 claims description 51
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 50
- 125000000232 haloalkynyl group Chemical group 0.000 claims description 50
- 125000001188 haloalkyl group Chemical group 0.000 claims description 49
- 125000001424 substituent group Chemical group 0.000 claims description 45
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 44
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 41
- 125000003545 alkoxy group Chemical group 0.000 claims description 40
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 40
- 125000000262 haloalkenyl group Chemical group 0.000 claims description 38
- 229910052799 carbon Inorganic materials 0.000 claims description 36
- 125000000623 heterocyclic group Chemical group 0.000 claims description 34
- 229920006395 saturated elastomer Polymers 0.000 claims description 34
- 125000000217 alkyl group Chemical group 0.000 claims description 33
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 32
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 30
- 125000000304 alkynyl group Chemical group 0.000 claims description 29
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 28
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 28
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 28
- 125000005347 halocycloalkyl group Chemical group 0.000 claims description 28
- 125000001072 heteroaryl group Chemical group 0.000 claims description 28
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 27
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 27
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 27
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 27
- 150000001721 carbon Chemical group 0.000 claims description 26
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims description 25
- 125000003342 alkenyl group Chemical group 0.000 claims description 23
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 23
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 22
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 22
- 125000004414 alkyl thio group Chemical group 0.000 claims description 22
- 239000003085 diluting agent Substances 0.000 claims description 22
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 21
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims description 21
- 125000004995 haloalkylthio group Chemical group 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 21
- 125000004665 trialkylsilyl group Chemical group 0.000 claims description 20
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims description 19
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 19
- 125000003282 alkyl amino group Chemical group 0.000 claims description 19
- 229910052794 bromium Inorganic materials 0.000 claims description 19
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 19
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 claims description 19
- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims description 18
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 18
- 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 claims description 17
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 17
- 125000005120 alkyl cycloalkyl alkyl group Chemical group 0.000 claims description 17
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims description 17
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims description 16
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 16
- 125000005130 alkyl carbonyl thio group Chemical group 0.000 claims description 16
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 16
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 16
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 15
- 229910052801 chlorine Inorganic materials 0.000 claims description 15
- 125000004771 (C1-C4) haloalkylsulfinyl group Chemical group 0.000 claims description 14
- 239000004094 surface-active agent Substances 0.000 claims description 14
- 125000005842 heteroatom Chemical group 0.000 claims description 13
- 229910052740 iodine Inorganic materials 0.000 claims description 11
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 11
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 9
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 9
- 125000006660 (C3-C4) halocycloalkyl group Chemical group 0.000 claims description 8
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 8
- 229910052731 fluorine Inorganic materials 0.000 claims description 8
- 125000001624 naphthyl group Chemical group 0.000 claims description 8
- 125000004122 cyclic group Chemical group 0.000 claims description 7
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 5
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims description 5
- 125000004429 atom Chemical group 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 125000003386 piperidinyl group Chemical group 0.000 claims description 5
- 229910052717 sulfur Inorganic materials 0.000 claims description 5
- 125000004450 alkenylene group Chemical group 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 3
- 125000002837 carbocyclic group Chemical group 0.000 claims description 3
- 125000006699 (C1-C3) hydroxyalkyl group Chemical group 0.000 claims description 2
- 125000005195 alkyl amino carbonyloxy group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims 1
- 241000233654 Oomycetes Species 0.000 claims 1
- SNRBMGJIULYTAN-GOSISDBHSA-N 2-[1-[2-(2-chlorophenyl)acetyl]piperidin-4-yl]-n-methyl-n-[(1r)-1-phenylethyl]-1,3-thiazole-4-carboxamide Chemical compound CN([C@H](C)C=1C=CC=CC=1)C(=O)C(N=1)=CSC=1C(CC1)CCN1C(=O)CC1=CC=CC=C1Cl SNRBMGJIULYTAN-GOSISDBHSA-N 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 273
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 210
- 239000011541 reaction mixture Substances 0.000 description 146
- 238000002360 preparation method Methods 0.000 description 116
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 111
- 239000000243 solution Substances 0.000 description 105
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 101
- 239000000047 product Substances 0.000 description 100
- 238000005160 1H NMR spectroscopy Methods 0.000 description 91
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 88
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 84
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 73
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 description 72
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 64
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 62
- 230000002829 reductive effect Effects 0.000 description 60
- 125000004497 pyrazol-5-yl group Chemical group N1N=CC=C1* 0.000 description 58
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 56
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 54
- 238000006243 chemical reaction Methods 0.000 description 43
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 42
- 239000003921 oil Substances 0.000 description 40
- 235000019198 oils Nutrition 0.000 description 40
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 38
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 34
- 150000001412 amines Chemical class 0.000 description 31
- 239000002244 precipitate Substances 0.000 description 31
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 29
- 239000012267 brine Substances 0.000 description 28
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 28
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 28
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 28
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 26
- 238000003820 Medium-pressure liquid chromatography Methods 0.000 description 24
- 239000002253 acid Substances 0.000 description 23
- 239000000725 suspension Substances 0.000 description 22
- 238000009472 formulation Methods 0.000 description 20
- 239000000741 silica gel Substances 0.000 description 20
- 229910002027 silica gel Inorganic materials 0.000 description 20
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 20
- 241000196324 Embryophyta Species 0.000 description 18
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 18
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 18
- 125000002971 oxazolyl group Chemical group 0.000 description 18
- 239000000460 chlorine Substances 0.000 description 17
- 239000006260 foam Substances 0.000 description 17
- 235000019341 magnesium sulphate Nutrition 0.000 description 17
- 235000017557 sodium bicarbonate Nutrition 0.000 description 17
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 17
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 16
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 16
- 235000011181 potassium carbonates Nutrition 0.000 description 16
- 238000010898 silica gel chromatography Methods 0.000 description 16
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 15
- 239000002904 solvent Substances 0.000 description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
- 239000000284 extract Substances 0.000 description 14
- 239000012044 organic layer Substances 0.000 description 14
- 229910000027 potassium carbonate Inorganic materials 0.000 description 14
- 239000007864 aqueous solution Substances 0.000 description 13
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 12
- 238000003756 stirring Methods 0.000 description 12
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 description 11
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 11
- 239000004480 active ingredient Substances 0.000 description 11
- 125000003118 aryl group Chemical group 0.000 description 11
- 239000002585 base Substances 0.000 description 11
- 239000012043 crude product Substances 0.000 description 11
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 11
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 11
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 10
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 10
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 10
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 10
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 description 10
- 230000003197 catalytic effect Effects 0.000 description 10
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 230000008878 coupling Effects 0.000 description 9
- 238000010168 coupling process Methods 0.000 description 9
- 238000005859 coupling reaction Methods 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 9
- 150000002148 esters Chemical class 0.000 description 9
- 239000000194 fatty acid Substances 0.000 description 9
- 229930195729 fatty acid Natural products 0.000 description 9
- 239000010410 layer Substances 0.000 description 9
- 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 description 9
- 150000003254 radicals Chemical class 0.000 description 9
- XERJKGMBORTKEO-VZUCSPMQSA-N (1e)-2-(ethylcarbamoylamino)-n-methoxy-2-oxoethanimidoyl cyanide Chemical compound CCNC(=O)NC(=O)C(\C#N)=N\OC XERJKGMBORTKEO-VZUCSPMQSA-N 0.000 description 8
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 8
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 239000000706 filtrate Substances 0.000 description 8
- CFHGBZLNZZVTAY-UHFFFAOYSA-N lawesson's reagent Chemical compound C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 description 8
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 8
- 125000006239 protecting group Chemical group 0.000 description 8
- 239000012047 saturated solution Substances 0.000 description 8
- 238000003786 synthesis reaction Methods 0.000 description 8
- 125000006305 3-iodophenyl group Chemical group [H]C1=C([H])C(I)=C([H])C(*)=C1[H] 0.000 description 7
- 150000001408 amides Chemical class 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000000543 intermediate Substances 0.000 description 7
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 229940124530 sulfonamide Drugs 0.000 description 7
- 150000003871 sulfonates Chemical class 0.000 description 7
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 description 6
- 238000005481 NMR spectroscopy Methods 0.000 description 6
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000004495 emulsifiable concentrate Substances 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
- 238000010992 reflux Methods 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 125000002827 triflate group Chemical group FC(S(=O)(=O)O*)(F)F 0.000 description 6
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 5
- RBHQAIFXLJIFFM-UHFFFAOYSA-N 2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetic acid Chemical compound CC1=CC(C(F)(F)F)=NN1CC(O)=O RBHQAIFXLJIFFM-UHFFFAOYSA-N 0.000 description 5
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 5
- 150000001298 alcohols Chemical class 0.000 description 5
- 229910052763 palladium Inorganic materials 0.000 description 5
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 5
- 238000006722 reduction reaction Methods 0.000 description 5
- VFWCMGCRMGJXDK-UHFFFAOYSA-N 1-chlorobutane Chemical compound CCCCCl VFWCMGCRMGJXDK-UHFFFAOYSA-N 0.000 description 4
- PAQZWJGSJMLPMG-UHFFFAOYSA-N 2,4,6-tripropyl-1,3,5,2$l^{5},4$l^{5},6$l^{5}-trioxatriphosphinane 2,4,6-trioxide Chemical compound CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1 PAQZWJGSJMLPMG-UHFFFAOYSA-N 0.000 description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 4
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Chemical compound CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- PQJJJMRNHATNKG-UHFFFAOYSA-N ethyl bromoacetate Chemical compound CCOC(=O)CBr PQJJJMRNHATNKG-UHFFFAOYSA-N 0.000 description 4
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- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical class C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000004550 soluble concentrate Substances 0.000 description 1
- JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000005504 styryl group Chemical group 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 150000003444 succinic acids Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000004546 suspension concentrate Substances 0.000 description 1
- 239000004548 suspo-emulsion Substances 0.000 description 1
- 239000000271 synthetic detergent Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- PRSCQGFOXHJHQZ-UHFFFAOYSA-N tert-butyl 4-(3-methoxycarbonylpyrazol-1-yl)piperidine-1-carboxylate Chemical compound N1=C(C(=O)OC)C=CN1C1CCN(C(=O)OC(C)(C)C)CC1 PRSCQGFOXHJHQZ-UHFFFAOYSA-N 0.000 description 1
- SWDVDDQIYQRMHZ-UHFFFAOYSA-N tert-butyl 4-(4-ethoxycarbonylpyrazol-1-yl)piperidine-1-carboxylate Chemical compound C1=C(C(=O)OCC)C=NN1C1CCN(C(=O)OC(C)(C)C)CC1 SWDVDDQIYQRMHZ-UHFFFAOYSA-N 0.000 description 1
- BLNUITXDTYBOKB-UHFFFAOYSA-N tert-butyl 4-(5-methoxycarbonylpyrazol-1-yl)piperidine-1-carboxylate Chemical compound COC(=O)C1=CC=NN1C1CCN(C(=O)OC(C)(C)C)CC1 BLNUITXDTYBOKB-UHFFFAOYSA-N 0.000 description 1
- WMOVHXAZOJBABW-UHFFFAOYSA-N tert-butyl acetate Chemical compound CC(=O)OC(C)(C)C WMOVHXAZOJBABW-UHFFFAOYSA-N 0.000 description 1
- CWXPZXBSDSIRCS-UHFFFAOYSA-N tert-butyl piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCNCC1 CWXPZXBSDSIRCS-UHFFFAOYSA-N 0.000 description 1
- MNRDWQRMQBZBBJ-UHFFFAOYSA-N tert-butyl piperazine-1-carboxylate;methyl 2-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-1,3-thiazole-5-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCNCC1.S1C(C(=O)OC)=CN=C1N1CCN(C(=O)OC(C)(C)C)CC1 MNRDWQRMQBZBBJ-UHFFFAOYSA-N 0.000 description 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- ZDRNMODJXFOYMN-UHFFFAOYSA-N tridecyl acetate Chemical compound CCCCCCCCCCCCCOC(C)=O ZDRNMODJXFOYMN-UHFFFAOYSA-N 0.000 description 1
- 229940087291 tridecyl alcohol Drugs 0.000 description 1
- MCVUKOYZUCWLQQ-UHFFFAOYSA-N tridecylbenzene Chemical class CCCCCCCCCCCCCC1=CC=CC=C1 MCVUKOYZUCWLQQ-UHFFFAOYSA-N 0.000 description 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 230000006442 vascular tone Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Definitions
- This invention relates to certain carboxamides, their iV-oxides, agriculturally suitable salts and compositions, and methods of their use as fungicides.
- World Patent Publication WO 05/003128 discloses thiazolylpiperidine derivatives of Formula i as MTP (Microsomal Triglyceride transfer Protein) inhibitors.
- MTP Mericrosomal Triglyceride transfer Protein
- A is a radical selected from the radicals al and a2 below
- R 1 , R 2 , R 2' , R 3 , R 4 and R 5 are as defined in the disclosure.
- World Patent Publication WO 04/058751 discloses piperidinyl-thiazole carboxamide derivatives for altering vascular tone.
- This invention is directed to compounds of Formula 1 including all geometric and stereoisomers, iV-oxides, and agriculturally suitable salts thereof, agricultural compositions containing them and their use as fungicides:
- R 1 is an optionally substituted phenyl or 5- or 6-membered heteroaromatic ring
- A is CH 2 or NH
- Wl is O or S
- X is a radical selected from
- each R 2 is independently Cj-C 4 alkyl, C j -C 4 alkenyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, halogen, cyano or hydroxy; n is 0, 1 or 2; or two R 2 are taken together as C].
- G is an optionally substituted 5-membered heteroaromatic ring or 5-membered saturated or partially saturated heterocyclic ring;
- W 2 is O or S;
- Q is -NQ a Q b ;
- Q a is H, C 1 -C 3 alkyl, C 2 -C 3 alkenyl, C 2 -C 3 alkynyl, C 4 -C 10 cycloalkylalkyl, C 4 -C 10 alkylcycloalkyl, C 5 -C 10 alkylcycloalkylalkyl, C 1 -C 3 haloalkyl, C 2 -C 3 haloalkenyl, cyano, hydroxy, C 1 -C 3 alkoxy, C 2 -C 3 alkoxyalkyl, C 1 -C 3 hydroxyalkyl, C 2 -C 3 alkylcarbonyl, C 2 -C 3 alkoxycarbonyl, C 2 -C 3 alkylaminocarbonyl or C 3 -Cs dialkylarninocarbonyl; Q b is an optionally substituted 8- to 11-membered saturated or partially saturated bicyclic ring system or an optionally substituted 10- to 15-membered
- Q a and Q b are taken together with the nitrogen atom to which they are bonded to form an optionally substituted 5- or 6-membered saturated or partially saturated heterocyclic ring;
- R 5 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 4 -C 10 cycloalkylalkyl, C 4 -C 10 alkylcycloalkyl, C 5 -C 10 alkylcycloalkylalkyl, C 1 -C 6 haloalkyl, C 2 -C 6 haloalkenyl, C 2 -C 6 haloalkynyl, C 3 -C 6 halocycloalkyl, cyano, nitro, C 2 -C 4 alkoxyalkyl, C 1 -C 4 hydroxyalkyl, C 2 -C 4 alkylcarbonyl, C 2 -C 6
- R 6 is an optionally substituted phenyl, benzyl, naphthalenyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkenyl or 5- or 6-membered heteroaromatic ring; and R 15 is H, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 4 cycloalkyl, C 4 -C 10 cycloalkylalkyl, C 4 -C 10 alkylcycloalkyl, C 5 -C 10 alkylcycloalkylalkyl, C 1 -C 4 haloalkyl, C 2 -C 4 haloalkenyl, C 2 -C 4 haloalkynyl, C 3 -C 4 halocycloalkyl or C 2 -
- Q a and R 5 are taken together with the atoms connecting them to form an optionally substituted 5- to 7-membered ring containing as ring members 2 to 7 carbon atoms and optionally 1 to 3 heteroatoms selected from up to 1 O, up to 1 S and up to 2 N; or Q a and R 6 are taken together with the atoms connecting them to form an optionally substituted 5- to 7-membered ring containing as ring members 2 to 7 carbon atoms and optionally 1 to 3 heteroatoms selected from up to 1 O, up to 1 S and up to 2 N; or R 5 and R 15 are taken together with the carbon atom to which they are bonded to form an optionally substituted 5- to 7-membered ring containing as ring members 2 to 7 carbon atoms and, optionally 1 to 3 heteroatoms selected from up to 1 O, up to 1 S and up to 1 N; or R 5 and R 6 are taken together with the carbon atom to which they are bonded to form an optionally substituted 5- to 7-membered
- the compound of Formula 1 is other than 2-[l ⁇ [(2-chlorophenyl)acetyl]-4- piperidinyl] -iV-methyl-iV- [( IR)- 1 -phenylethyl] -4-thiazolec arboxamide; (b) when X is X 2 , X 3 , X 4 , X 6 or X 8 , then G is not linked to X via a heteroatom of the
- R 1 is other than 4-fluorophenyl.
- this invention pertains to a compound of Formula 1, including all geometric and stereoisomers, an N-oxide or an agriculturally suitable salt thereof.
- This invention also relates to a fungicidal composition comprising a fungicidally effective amount of a compound of Formula 1 and at least one additional component selected from the group consisting of surfactants, solid diluents or liquid diluents.
- This invention also relates to a fungicidal composition
- a fungicidal composition comprising a mixture of a compound of Formula 1 and at least one other fungicide, particularly at least one other fungicide having a different mode of action.
- This invention further relates to a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed or seedling, a fungicidally effective amount of a compound of the invention (i.e. as a composition described herein).
- This invention also provides a fungicidal composition comprising a fungicidally effective amount of a compound having a formula corresponding to Formula 1 except that R 1 is 4-fluorophenyl and at least one additional component selected from the group consisting of surfactants, solid diluents or liquid diluents.
- This invention also relates to a fungicidal composition
- a fungicidal composition comprising a fungicidally effective amount of a compound having a formula corresponding to Formula 1 except that R 1 is 4-fluorophenyl and at least one other fungicide.
- This invention further relates to a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed or seedling, a fungicidally effective amount of the compound having a formula corresponding to Formula 1 except that R 1 is 4-fluorophenyl (i.e. as a composition described herein).
- This invention also provides a fungicidal composition
- a fungicidal composition comprising a fungicidally effective amount of the compound of 2-[l-[(2-chlorophenyl)acetyl]-4-piperidinyl] ⁇ N-methyl- N-[(li?)-l-phenylethyl]-4-thiazolecarboxaniide and at least one additional component selected from the group consisting of surfactants, solid diluents or liquid diluents.
- This invention also relates to a fungicidal composition
- a fungicidal composition comprising a mixture of the compound of 2- [ 1 - [(2-chlorophenyl)acetyl] -4-piperidinyl] -JV-methyl-iV- [( Ii?)- 1 - phenylethyl]-4-thiazolecarboxamide and at least one other fungicide.
- This invention further relates to a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed or seedling, a fungicidally effective amount of the compound of 2-[l-[(2- chlorophenyl)acetyl]-4-piperidinyl]-N-methyl-N-[(li?)-l-phenylethyl]-4-thiazole- carboxamide (i.e. as a composition described herein).
- compositions comprising, “comprising,” “includes,” “including,” “has,” “having” or any other variation thereof, are intended to cover a non-exclusive inclusion.
- a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
- “or” refers to an inclusive or and not to an exclusive or. For example, a condition A or B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and Both A and B are true (or present).
- alkyl used either alone or in compound words such as “alkylthio” or “haloalkyl” includes straight-chain or branched alkyl, such as, methyl, ethyl, n-propyl, /-propyl, or the different butyl, pentyl or hexyl isomers.
- alkyl indicates that one or two of the available positions for that substituent may be alkyl which are independently selected.
- alkenyl includes straight-chain or branched alkenes such as ethenyl, 1-propenyl, 2-propenyl, and the different butenyl, pentenyl and hexenyl isomers.
- Alkenyl also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl.
- Alkynyl includes straight-chain or branched alkynes such as ethynyl, 1-propynyl, 2-propynyl and the different butynyl, pentynyl and hexynyl isomers. "Alkynyl” can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl. "Alkylene” denotes a straight-chain or branched alkanediyl. Examples of “alkylene” include CH2, CH 2 CH 2 , CH(CH 3 ), CH 2 CH 2 CH 2 , CH 2 CH(CH 3 ) and the different butylene isomers.
- Alkoxy includes, for example, methoxy, ethoxy, rc-propyloxy, isopropyloxy and the different butoxy, pentoxy and hexyloxy isomers.
- Alkoxyalkyl denotes alkoxy substitution on alkyl. Examples of “alkoxyalkyl” include CH 3 OCH 2 , CH 3 OCH 2 CH 2 , CH 3 CH 2 OCH 2 , CH 3 CH 2 CH 2 CH 2 OCH 2 and CH 3 CH 2 OCH 2 CH 2 .
- Alkoxyalkoxy denotes alkoxy substitution on alkoxy.
- Alkenyloxy includes straight-chain or branched alkenyloxy moieties.
- Alkylthio includes branched or straight-chain alkylthio moieties such as methylthio, ethylthio, and the different propylthio, butylthio, pentylthio and hexylthio isomers.
- Alkylsulfinyl includes both enantiomers of an alkylsulfinyl group. Examples of “alkylsulfinyl” include CH 3 S(O), CH 3 CH 2 S(O), CH 3 CH 2 CH 2 S(O), (CH 3 ) 2 CHS(O) and the different butylsulfinyl, pentylsulfinyl and hexylsulfinyl isomers.
- alkylsulfonyl examples include CH 3 S(O) 2 , CH 3 CH 2 S(O) 2 , CH 3 CH 2 CH 2 S(O) 2 , (CH 3 ) 2 CHS(O) 2 and the different butylsulfonyl, pentylsulfonyl and hexylsulfonyl isomers.
- Alkylamino "dialkylamino”, “alkenylthio”, “alkenylsulfinyl”, “alkenylsulfonyl”, “alkynylthio”, “alkynylsulfinyl”, “alkynylsulfonyl”, and the like, are defined analogously to the above examples.
- Cycloalkyl includes, for example, cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.
- the term “carbocyclic ring” denotes a ring wherein the atoms forming the ring backbone and selected only from carbon.
- aromatic ring system denotes fully unsaturated carbocycles and heterocycles in which the polycyclic ring system is aromatic.
- Aromatic indicates that each of ring atoms is essentially in the same plane and has ap-orbital perpendicular to the ring plane, and in which (4n + 2) ⁇ electrons, when n is O or a positive integer, are associated with the ring to comply with H ⁇ ckel's rule.
- aromatic carbocyclic ring system includes fully aromatic carbocycles and carbocycles in which at least one ring of a polycyclic ring system is aromatic.
- aromatic heterocyclic ring system and “heteroaromatic ring” include fully aromatic heterocycles and heterocycles in which at least one ring of a polycyclic ring system is aromatic.
- saturated heterocyclic ring system denotes fully saturated heterocycles wherein none of the rings in the ring system are aromatic.
- partially saturated heterocyclic ring system denotes partially unsaturated heterocycles wherein part of the rings in the ring system can be aromatic.
- the heterocyclic ring systems can be attached through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen.
- Synthetic methods for the preparation of iV-oxides of heterocycles and tertiary amines are very well known by one skilled in the art including the oxidation of heterocycles and tertiary amines with peroxy acids such as peracetic and m-chloroperbenzoic acid (MCPBA), hydrogen peroxide, alkyl hydroperoxides such as t-butyl hydroperoxide, sodium perborate, and dioxiranes such as dimethydioxirane.
- MCPBA peroxy acids
- alkyl hydroperoxides such as t-butyl hydroperoxide
- sodium perborate sodium perborate
- dioxiranes such as dimethydioxirane
- halogen either alone or in compound words such as “haloalkyl”, includes fluorine, chlorine, bromine or iodine.
- 1-2 halogen indicates that one or two of the available positions for that substituent may be halogen which are independently selected. Further, when used in compound words such as “haloalkyl”, said alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Examples of “haloalkyl” include F 3 C, ClCH 2 , CF 3 CH 2 and CF 3 CCl 2 .
- haloalkoxy examples include CF 3 O, CCl 3 CH 2 O, HCF 2 CH 2 CH 2 O and CF 3 CH 2 O.
- haloalkylthio examples include CCl 3 S, CF 3 S, CCl 3 CH 2 S and ClCH 2 CH 2 CH 2 S.
- haloalkylsulfinyl examples include CF 3 S(O), CCl 3 S(O), CF 3 CH 2 S(O) and CF 3 CF 2 S(O).
- haloalkylsulfonyl examples include CF 3 S(O) 2 , CCl 3 S(O) 2 , CF 3 CH 2 S(O) 2 and CF 3 CF 2 S(O) 2 .
- Examples of “partially saturated bicyclic ring system” include tetrahydronaphthalene, tetrahydroquinoline, tetrahydroisoquinoline.
- Trialkylsilyl includes 3 branched and/or straight-chain alkyl radicals attached to and linked through a silicon atom such as trimethylsilyl, triethylsilyl and t-butyl-dimethylsilyl. The total number of carbon atoms in a substituent group is indicated by the “Cj-C j " prefix where i and j are numbers from 1 to 10.
- C 1 -C 4 alkylsulfonyl designates methylsulfonyl through butylsulfonyl
- C 2 alkoxyalkyl designates CH 3 OCH 2
- C 3 alkoxyalkyl designates, for example, CH 3 CH(OCH 3 ), CH 3 OCH 2 CH 2 or CH 3 CH 2 OCH 2
- C 4 alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH 3 CH 2 CH 2 OCH 2 and CH 3 CH 2 OCH 2 CH 2 .
- C 2 alkylaminoalkyl designates CH 3 NHCH 2 -;
- C 3 alkylaminoalkyl designates, for example, CH 3 (CH 3 NH)CH-, CH 3 NHCH 2 CH 2 - or CH 3 CH 2 NHCH 2 -;
- alkylcarbonyl include C(O)CH 3 , C(O)CH 2 CH 2 CH 3 and C(O)CH(CH 3 ) 2 .
- a compound of Formula 1 when a compound of Formula 1 is comprised of one or more heterocyclic rings, all substituents are attached to these rings through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen.
- the dotted line in Formula 1 represents that the bond indicated can be a single bond or double bond.
- a group contains a substituent which can be hydrogen, for example Q a , R 5 or R 1 ⁇ 1 then, when this substituent is taken as hydrogen, it is recognized that this is equivalent to said group being unsubstituted.
- a variable group is shown to be optionally attached to a position, for example (R 2 ) n wherein n may be 0, then hydrogen may be at the position even if not recited in the variable group definition.
- a position on a group is said to be "not substituted” or "unsubstituted”
- hydrogen atoms are attached to take up any free valency.
- R 1 , R 2 , R 5 , R 6 , R 15 , R 16 , R 16a , G, Q a and Q b refers to groups that are unsubstituted or have at least 1 non-hydrogen substituent. These groups may be substituted with as many optional substituents as can be accommodated by replacing a hydrogen atom with a non-hydrogen substituent on any available carbon or nitrogen atom. Commonly, the number of optional substituents (when present) ranges from 1 to 3.
- R 1 is an optionally substituted phenyl or 5- or 6-membered heteroaromatic ring
- G is an optionally substituted 5-membered heteroaromatic ring or 5- membered saturated or partially saturated heterocyclic ring
- Q a and Q b are taken together with the nitrogen atom to which they are bonded to form an optionally substituted 5- or 6- membered saturated or partially saturated heterocyclic ring
- R 6 is an optionally substituted phenyl, benzyl, naphthalenyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkenyl or 5- or 6- membered heteroaromatic ring
- Q-2 through Q-85 are optionally substituted.
- substituted in connection with these R 1 , G, R 6 , Q a and Q b groups refers to groups that have at least one non-hydrogen substituent that does not extinguish the fungicidal activity. Since these groups are optionally substituted, they need not have any non-hydrogen substituents.
- pyrazol-1-yl means "lH-pyrazol-l-yl” according to the Chemical Abstracts system of nomenclature.
- pyridyl is synonymous with “pyridinyl”. The order of listing substituents may be different from the Chemical Abstracts system if the difference does not affect the meaning.
- Examples of compounds of Formula 1 include compounds wherein R 1 is a phenyl or 5- or 6-membered heteroaromatic ring, optionally substituted with 1 to 2 substituents independently selected from R 4 ; each R 4 is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 4 -C 10 cycloalkylalkyl, C 4 -C 10 alkylcycloalkyl, C5-C 10 alkylcycloalkylalkyl, C 1 -C 6 haloalkyl, C 2 -C 6 haloalkenyl, C 2 -C 6 haloalkynyl, C 3 -C 6 halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 alkoxy,
- R 1 is one of U-I through U- 50 as described in connection with Embodiment 14 described hereinafter; G is one of G-I through G-55 as described in connection with Embodiment 36 described hereinafter; each R 3a is independently H, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl or halogen (more particularly H, C 1 - C 3 alkyl or halogen, and most particularly H or C 1 -C 3 alkyl); R l la is H or C 1 -C 3 alkyl; R 6 is one of H-I through H-46 as described in connection with Embodiment 65 described hereinafter; and R*2 ⁇ $ H or C 1 -C 3 alkyl.
- each R 4 is independently C 1 -C 3 alkyl, C 2 -C 3 alkenyl, C 2 -C 3 alkynyl, cyclopropyl, C 1 -C 3 haloalkyl, C 2 -C 3 haloalkenyl, C 2 -C 3 haloalkynyl, halocyclopropyl, halogen, cyano, nitro, C 1 -C 2 alkoxy or C 1 -C 2 haloalkoxy;
- R 5 is C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 4 cycloalkyl, C 1 -C 4 haloalkyl, C 2 -C 4 haloalkenyl, C 2 -C 4 haloalkynyl, C 3 -C 4 halocycloalkyl, cyano or C 2 -C
- Examples of the compounds of the Paragraph B above include compounds wherein
- X is one of X 1 , X 2 and X 3 ; and each R 2 is independently C 1 -C 2 alkyl, C j -C 2 haloalkyl, C 1 - C 2 alkoxy, halogen, cyano or hydroxy; Q a is H or CH3; and R 15 is H or CH3.
- Examples of the compounds of the Paragraph C above include compounds wherein R 1 is one of U-I through U-3, U-Il, U-13, U-20, U-22, U-23, U-36, U-37 through U-39 and U-50; and each R 4 is independently halogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, Cj-C 2 alkoxy or C 1 -C 2 haloalkoxy.
- G is G-I, G-2, G-3, G-7, G-8, G-10, G-Il, G-14, G-15, G-23, G-24, G-26, G-Tl, G-28, G-30, G-36, G-37, G-38 or G-49 through G-55;
- R 3a is H, CH 3 , Cl or Br;
- R 11 is H or CH 3 .
- G is G-I, G-2, G-7, G-8, G-14, G-15, G-23, G-24, G-26, G-Tl, G-36, G-37, G-38, G-49 or G-50 (including e.g., where G is unsubstituted).
- R 5 is C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 4 cycloalkyl, C 1 - C 4 haloalkyl, C 2 -C 4 haloalkenyl, C 2 -C 4 haloalkynyl, C 3 -C 4 halocycloalkyl, cyano or C 2 - C 4 alkoxyalkyl; R 6 is H-I, H-20, H-32, H-45 or H-46; each R?
- each R 8 is independently C 1 -C 2 alkyl, C 1 -C 2 haloalkyl, C 1 -C 2 alkoxy, C 1 -C 2 haloalkoxy, C 2 -C 4 alkylcarbonyloxy or hydroxy; and each R 9 is independently halogen, hydroxy, OCH 3 or CH 3 .
- Q is Q-I, Q-2, Q-8, Q-14, Q-23, Q-41, Q-59 or Q-62;
- Q a is methyl;
- R 5 is C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 haloalkenyl or cyano;
- R 6 is H-I or H-45;
- R 12 is H or CH 3 ; each R 7 is independently F, Cl, Br, OCH 3 or methyl;
- R 15 is H;
- R 8 is CH 3 , OCH 3 or OH; and
- RlO is H or CH 3 .
- Additional examples of the compounds of Paragraph C include compounds wherein W 1 and W 2 are independently O; Q a is CH 3 ; m, j, n and p are all independently 0 or 1; R 3a is H; each R 7 is independently F, Cl, Br, OCH 3 or methyl; each R 8 is independently C 1 -C 2 alkyl, C 1 -C 2 alkoxy or hydroxy; and each R 9 is independently F, Cl, Br, hydroxy, OCH 3 or CH 3 .
- R 1 is U-I or U-50; each R 4 is independently halogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl or C 1 -C 2 alkoxy; G is G-I, G-2, G-15, G-26, G-27, G-36, G- 37 or G-38; Q is Q-I, Q-2 , Q-8, Q-23 or Q-41; R 5 is C 1 -C 4 alkyl, C 2 -C 4 alkenyl or cyano; R 6 is H-45; and each R 4 is independently connected to the 3- or 5-position of U-I, each R 4 is independently connected to the 3- and 5-position of U-I, each R 4 is independently connected to the 2- or 3-position of U-50, or each R 4 is independently connected to the 2- and 5- position of U-50 (e.g., compounds where X is X 1 and G is G-I; X is X 1 and G is G-2; X is X is X 1 and G is G-2
- X I and G is G-15; X is X 1 and G is G-26; X is Xl and G is G-36; X is X 2 and G is G-I; or X is X 2 and G is G-2).
- each R 4 is independently connected to the 3- or 5- position of U-I” means k is 1 and R 4 is connected to the 3- or 5-position of U-I, "each R 4 is independently connected to the 3- and 5-position of U-I” means k is 2 and an independently selected R 4 is connected to each of the 3- and 5-positions of U-I, “each R 4 is independently connected to the 2- or 3-position of U-50” means k is 1 and R 4 is connected to the 3- or 5- position of U-50, and “each R 4 is independently connected to the 2- and 5-position of U-50” means k is 2 and an independently selected R 4 is connected to each of the 2- and 5-positions of U-50.
- Stereoisomers of this invention can exist as one or more stereoisomers.
- the various stereoisomers include enantiomers, diastereomers, atropisomers and geometric isomers.
- one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s).
- the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers.
- the present invention comprises compounds selected from Formula 1, iV-oxides and agriculturally suitable salts thereof.
- the compounds of the invention may be present as a mixture of stereoisomers, individual stereoisomers, or as an optically active form.
- ee which is defined as (2x-l)-100 %, where x is the mole fraction of the dominant enantiomer in the mixture (e.g., an ee of 20 % corresponds to a 60:40 ratio of enantiomers).
- the more fungicidally active enantiomer is believed to be that wherein R 15 is a hydrogen, the hydrogen atom attached to the carbon atom identified with an asterisk (*) is below the plane defined by the 3 non-hydrogen atoms attached to the carbon atom identified with the asterisk (*) as in Formula 1' (with the aromatic ring of Q-2 through Q-74 positioned with respect to the carbon atom identified with an asterisk (*) in a manner analogous to R 6 in Q-I in Formula 1').
- R 5 is CH 3
- R 6 is phenyl and R 15 is H
- Formula I 1 has the R configuration at the carbon atom to which R 5 , R 6 and R 15 are commonly bonded.
- compositions of this invention have at least a 50 % enantiomeric excess; more preferably at least a 75 % enantiomeric excess; still more preferably at least a 90 % enantiomeric excess; and the most preferably at least a 94 % enantiomeric excess of the more active isomer.
- enantiomerically pure embodiments of the more active isomer are enantiomerically pure embodiments of the more active isomer.
- Compounds of Formula 1 can comprise additional chiral centers.
- the substituents R 4 , R 5 , R 7 , R 8 , R 9 , R 13 , R 15 , R 16 , R 16a , Q a , Q b and ⁇ l through ⁇ 8 may themselves contain chiral centers.
- This invention comprises racemic mixtures as well as enriched and essentially pure stereoconfigurations at these additional chiral centers.
- Compounds of this invention can exist as one or more conformational isomers due to the amide bonds in the compounds of Formula 1 as known by one skilled in the art.
- This invention comprises mixtures of conformational isomers.
- this invention includes compounds that are enriched compared to the mixture of a conformer of Formula 1.
- the agriculturally suitable salts of the compounds of the invention include acid-addition salts with inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric acids.
- inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric acids.
- the agriculturally suitable salts of the compounds of the invention also include those formed with organic bases (e.g., pyridine, ammonia, or triethylamine) or inorganic bases (e.g., hydrides, hydroxides, or carbonates of sodium, potassium, lithium, calcium, magnesium or barium) when the compound contains an acidic group such as a carboxylic acid or phenol.
- organic bases e.g., pyridine, ammonia, or triethylamine
- inorganic bases e.g., hydrides, hydroxides, or carbonates of sodium, potassium, lithium, calcium, magnesium or barium
- an acidic group such as a carboxylic acid or phenol.
- Embodiment 1 A compound of Formula 1 wherein A is CE ⁇ - Embodiment 2. A compound of Formula 1 wherein A is NH. Embodiment 3. A compound of Formula 1 wherein W 1 is O. Embodiment 4. A compound of Formula 1 wherein W 1 is S. Embodiment 5. A compound of Formula 1 wherein W 2 is O.
- Embodiment 6 A compound of Formula 1 wherein W 2 is S.
- Embodiment 7. A compound of Formula 1 wherein R 2 is methyl.
- Embodiment 8. A compound of Formula 1 wherein n is 0 or 1.
- Embodiment 9. A compound of Embodiment 8 wherein n is 0.
- Embodiment 10. A compound of Formula 1 wherein X is X 1 , X 2 or X 3 .
- Embodiment 11 A compound of Embodiment 10 wherein X is X 1 or X 2 and each ring is saturated.
- a compound of Embodiment 14 wherein R 1 is selected from U-I through U-5, U-8, U-Il, U-13, U-15, U-20 through U-28, U-31, U-36, U-37, U-38, U-39 and U-50.
- Embodiment 16 A compound of Embodiment 15 wherein R 1 is selected from U-I through U-3, U-5, U-8, U-13, U-20, U-22, U-23, U-25 through U-28, U-36 through U-39 and U-50.
- Embodiment 17 A compound of Embodiment 16 wherein R 1 is selected from U-I through U-3, U-13, U-20, U-22, U-23, U-36 through U-39 and U-50.
- Embodiment 18 A compound of Embodiment 17 wherein R 1 is U-I or U-50.
- Embodiment 19 A compound of Embodiment 18 wherein R 1 is U-I.
- Embodiment 19a A compound of any one of Formula 1 and Embodiments 18 and 19 where X is X 1 , X 2 or X 3 , each R 2 is independently C 1 -Cs alkyl, G is an optionally substituted 5-membered heteroaromatic ring containing 1 to 3 heteroatoms selected from 0 to 1 O, 0 to 1 S and 0 to 3 N, Q a is CH 3 , Q b is radical selected from
- R 5 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 1 -C 6 haloalkyl, C 2 -C 6 haloalkenyl, C 2 -C 6 haloalkynyl, C 3 - C 6 halocycloalkyl, cyano, nitro, C 2 -C 4 alkoxyalkyl, C 1 -C 4 hydroxyalkyl, C 2 -C 4 alkylcarbonyl, C 2 -C 6 alkoxycarbonyl, C 2 -C 6 alkylaminocarbonyl, C 3 -Cg dialkylaminocarbonyl or C 3 -C 6 trialkylsilyl, and R ⁇ is an optionally substituted phenyl,
- Embodiment 20 A compound of Embodiment 18 wherein R 1 is U-50.
- Embodiment 21 A compound of Formula 1 wherein R 1 is a phenyl or 5- or 6- membered heteroaromatic ring, optionally substituted with 1 to 2 substituents independently selected from R 4 and each R 4 is independently C 1 -C 3 alkyl, C 2 - C 3 alkenyl, C 2 -C 3 alkynyl, cyclopropyl, C 1 -C 3 haloalkyl, C 2 -C 3 haloalkenyl, C 2 -C 3 haloalkynyl, halocyclopropyl, halogen, cyano, nitro, C 1 -C 2 alkoxy, C 1 - C 2 haloalkoxy, C 1 -C 2 alkylthio, C 1 -C 2 haloalkylthio, C 1 -C 2 alkoxyalkyl, C 2 - C 3 alkylcarbonyl, C 2 -C 3 alkoxycarbonyl, C 2 -C 3
- Embodiment 22 A compound of Embodiment 21 wherein each R 4 is independently C ⁇ -C 3 alkyl, C 2 -C 3 alkenyl, C 2 -C 3 alkynyl, cyclopropyl, C 1 -C 3 haloalkyl, C 2 - C 3 haloalkenyl, C 2 -C 3 haloalkynyl, halocyclopropyl, halogen, cyano, nitro, C 1 - C 2 alkoxy or C 1 -C 2 haloalkoxy.
- Embodiment 23 A compound of Embodiment 22 wherein each R 4 is independently halogen, C 1 -C 3 alkyl, C 1 -C 3 haloalkyl, C 1 -C 2 alkoxy or C 1 -C 2 haloalkoxy.
- Embodiment 24 A compound of Embodiment 23 wherein each R 4 is independently halogen, C 1 -C 2 alkyl, C 1 -C 2 haloalkyl or C 1 -C 2 alkoxy.
- Embodiment 25 A compound of Embodiment 24 wherein each R 4 is independently Cl, Br, I, methyl, ethyl, trifluoromethyl or methoxy.
- Embodiment 26 A compound of Embodiment 25 wherein at least one R 4 is Cl.
- Embodiment 27 A compound of Embodiment 25 wherein at least one R 4 is Br.
- Embodiment 28 A compound of Embodiment 25 wherein at least one R 4 is methyl.
- Embodiment 29 A compound of Embodiment 25 wherein at least one R 4 is ethyl.
- Embodiment 30 A compound of Embodiment 25 wherein at least one R 4 is trifluoromethyl.
- Embodiment 31 A compound of Embodiment 25 wherein at least one R 4 is methoxy.
- Embodiment 32 A compound of Embodiment 19 wherein each R 4 is independently connected to the 3- or 5-position of U-I (i.e. k is 1, and R 4 is connected to the 3- or 5-position of U-I).
- Embodiment 32a A compound of Embodiment 19a wherein each R 4 is independently connected, to the 3- or 5-position of U-I (i.e. k is 1, and R 4 is connected to the 3- or 5-position of U-I); and each R 4 is independently C 1 -Cg alkyl, C 2 -Cg alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 1 -C 6 haloalkyl, C 2 -C 6 haloalkenyl, C 2 -C 6 haloalkynyl, C 3 -C 6 halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C 1 -
- Embodiment 33 A compound of Embodiment 19 wherein each R 4 is independently connected to the 3- and 5-position of U-I (i.e. k is 2, and an independently selected R 4 is connected to the 3- and 5-positions of U-I).
- each R 4 is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 1 -C 6 haloalkyl, C 2 -C 6 haloalkenyl, C 2 -C 6 haloalkynyl, C 3 -C 6 halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylsul
- Embodiment 34 A compound of Embodiment 20 wherein each R 4 is independently connected to the 2- or 3-position of U-50 (i.e. k is 1, and R 4 is connected to the 2- or 3-position of U-50).
- Embodiment 35 A compound of Embodiment 20 wherein each R 4 is independently connected to the 2- and 5-position of U-50 (i.e. k is 2, and an independently selected R 4 is connected to each of 2- and 5-positions of U-50).
- Embodiment 36 A compound of Formula 1 wherein G is one of G-I through G-55;
- Embodiment 37 A compound of Embodiment 36 wherein G is selected from G-I through G-3, G-I, G-8, G-10, G-Il, G-14, G-15, G-23, G-24, G-26 through G-
- Embodiment 38 A compound of Embodiment 37 wherein G is selected from G-I, G-
- Embodiment 39 A compound of Embodiment 38 wherein G is selected from G-I, G-
- Embodiment 40 A compound of Embodiment 39 wherein G is selected from G-I, G-
- Embodiment 41 A compound of Embodiment 40 wherein G is G-I. Of note are embodiments of these compounds within Embodiments 1 through 35,
- Embodiment 42 A compound of Embodiment 39 wherein G is G-2.
- G is G-2.
- Embodiment 43 A compound of Embodiment 36 wherein G is G- 15.
- G is G- 15.
- Embodiment 44 A compound of Embodiment 36 wherein G is G-26.
- G is G-26.
- Embodiments 1 through 35 Embodiments 46 through 96, Embodiments Al through A4, and Embodiments A6 through A13.
- Embodiment 45 A compound of Embodiment 36 wherein G is G-36. Of note are embodiments of these compounds within Embodiments 1 through 35, Embodiments 46 through 96, Embodiments Al through A4, and Embodiments A6 through A13.
- Embodiment 46 A compound of Formula 1 wherein G is a 5-membered heteroaromatic ring or 5-membered saturated or partially saturated heterocyclic ring, each ring optionally substituted with up to 2 substituents selected from R 3 on carbon ring members and selected from R ⁇ on nitrogen ring members; each R 11 is independently C 1 -C 3 alkyl; each R 3 is independently C 1 -C 3 alkyl or halogen.
- Embodiment 47 A compound of Embodiment 46 wherein R 3 is methyl.
- Embodiment 48 A compound of any one of Embodiments 36 through 45 wherein G is unsubstituted.
- Embodiment 49 A compound of Embodiment 36 wherein R 3a is H and R 11 is H or methyl.
- Embodiment 50 A compound of Formula 1 wherein Q is selected from Q-I through Q-85;
- R 15 is as described above, and for Q-2 through Q-76, each R 8 is independently attached to the carbon atoms of the nonaromatic carbocyclic ring or heterocyclic ring of the Q group, and each R 9 is independently attached to the carbon atoms of phenyl or heteroaromatic ring of the Q group; each R 8 is independently H, C 1 -C 4 alkyl, C2-C4 alkenyl, C 3 -C4 alkynyl, C 3 -C 6 cycloalkyl, C 1 -C 4 haloalkyl, C 2 -C 4 haloalkenyl, C 2 -C 4 haloalkynyl, C 3 -Cg halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 al
- R 16a is H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 4 -C 10 cycloalkylalkyl, C 4 -C 10 alkylcycloalkyl, C 5 -C 10 alkylcycloalkylalkyl, C 1 -C 6 haloalkyl, C 3 -C 6 haloalkenyl, C 3 -C 6 haloalkynyl, C 3 -C 6 halocycloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkylsulfonyl, C 1 -C 4 haloalkylsulfonyl, amino, C 1 -C 4 alkylamino, C 2 -C 8 dialkylamino, C 3 -C 6 cycloalkyla
- R 6 is a phenyl, benzyl, naphthalenyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkenyl or 5- or 6- membered heteroaromatic ring, each optionally substituted with 1 to 3 substituents selected from R 7 on carbon ring members and R 12 on nitrogen ring members; each R 7 is independently Q-C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 4 -C 1Q cycloalkylalkyl, C 4 -Cj 0 alkylcycloalkyl, C5-C 10 alkylcycloalkylalkyl, C 1 -C 6 haloalkyl, C 2 -C 6 haloalkenyl, C 2 -C 6 haloalkynyl,
- R 12 is H or C 1 -C 3 alkyl.
- Embodiment 51 A compound of Formula 1 wherein Q is selected from Q-I through Q-4, Q-8 through Q-10, Q-12, Q- 14, Q-22 through Q-24, Q-40, Q-41, Q-59, Q-
- Embodiment 52 A compound of Embodiment 51 wherein Q is Q-I, Q-2, Q-8, Q-14, Q-23, Q-41, Q-59 and Q-62.
- Embodiment 53 A compound of Embodiment 52 wherein Q is Q-I, Q-2, Q-8, Q-23 and Q-41.
- Embodiment 54 A compound of Embodiment 53 wherein Q is Q-I.
- Embodiment 55 A compound of Embodiment 53 wherein Q is Q-2.
- Embodiment 56 A compound of Embodiment 53 wherein Q is Q-8.
- Embodiment 57 A compound of Embodiment 53 wherein Q is Q-23.
- Embodiment 58 A compound of Embodiment 53 wherein Q is Q-41.
- Embodiment 59 A compound of Formula 1 wherein R 5 is C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 4 cycloalkyl, C 1 -C 4 haloalkyl, C 2 -C 4 haloalkenyl, C 2 -C 4 haloalkynyl, C 3 -C 4 halocycloalkyl, cyano, nitro, C 2 -C 4 alkoxyalkyl, C 2 - C 6 alkoxycarbonyl, C 2 -C 6 alkylaminocarbonyl or C 3 -C 8 dialkylaminocarbonyl.
- Embodiment 60 Embodiment 60.
- Embodiment 61 A compound of Embodiment 60 wherein R 5 is C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 haloalkenyl or cyano.
- Embodiment 62 A compound of Embodiment 61 wherein R 5 is C 1 -C 4 alkyl, C 2 -C 4 alkenyl or cyano.
- Embodiment 63 A compound of Embodiment 62 wherein R 5 is C 1 -C 3 alkyl.
- Embodiment 64 A compound of Embodiment 63 wherein R 5 is ethyl.
- Embodiment 65 A compound of Embodiment 50 wherein R 6 is one of H-I through H-46;
- each R 7 is independently C 1 -Cg alkyl, C 2 -Cg alkenyl, C 2 -Cg alkynyl, C ⁇ -Cg cycloalkyl, C 4 -CiQ cycloalkylalkyl, C4-C10 alkylcycloalkyl, C5-C10 alkylcycloalkylalkyl, C 1 -Cg haloalkyl, C 2 -Cg haloalkenyl, C 2 -Cg haloalkynyl, C3 ⁇ Cg halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, C 1 -C 4 haloalkylthio, C 1
- Embodiment 66 A compound of Embodiment 65 wherein R 6 is H-I, H-20, H-32, H- 45 or H-46.
- Embodiment 67 A compound of Embodiment 66 wherein R 6 is H-I or H-45.
- Embodiment 68 A compound of Embodiment 67 wherein R 6 is H-45.
- Embodiment 69 A compound of Formula 1 wherein Q b is CR 5 R 6 R 15 ; R 6 is a phenyl, benzyl, naphthalenyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkenyl or 5- or 6- membered heteroaromatic ring, each optionally substituted with 1 to 3 substituents selected from R 7 on carbon ring members and R 12 on nitrogen ring members; each R 7 is independently C 1 -C 3 alkyl, C2-C3 alkenyl, C2-C3 alkynyl, cyclopropyl, Ci-C 3 haloalkyl, C2-C3 haloalkenyl, C2-C3 haloalkynyl, halocyclopropyl, halogen, cyano, nitro, hydroxy, C1-C2 alkoxy, C 1 -C 2 haloalkoxy, C 1 -C 2 alkylthio, C
- Embodiment 73. A compound of Embodiment 72 wherein each R 7 is independently F,
- Embodiment 74 A compound of Embodiment 65 wherein p is 0.
- Embodiment 75 A compound of Embodiment 65 wherein R 12 is H or C 1 -C 2 alkyl.
- Embodiment 76 A compound of Embodiment 75 wherein R 12 is methyl.
- Embodiment 77. A compound of Formula 1 wherein R 15 is H, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 3 -C 4 cycloalkyl or C 1 -C 4 haloalkyl.
- Embodiment 78. A compound of Embodiment 77 wherein R 15 is H or C 1 -C 3 alkyl.
- Embodiment 79. A compound of Embodiment 78 wherein R 15 is H.
- Embodiment 80 A compound of Formula 1 wherein Q a is H or C 1 -C 3 alkyl.
- Embodiment 81. A compound of Embodiment 80 wherein Q a is H or methyl.
- each R 8 is independently H, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 3 -C 4 alkynyl, C 3 -C 6 cycloalkyl, C 1 -C 4 haloalkyl, C 2 -C 4 haloalkenyl, C 2 -C 4 haloalkynyl, C 3 -C 6 halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 alkoxy or C 2 -C 4 alkylcarbonyloxy.
- Embodiment 84 Embodiment 84.
- each R 8 is independently H, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 3 -C 4 alkynyl, C 3 -C 6 cycloalkyl, C 1 -C 4 haloalkyl, C 3 -C 6 halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 alkoxy or C2 ⁇ C 4 alkylcarbonyloxy.
- Embodiment 85 A compound of Embodiment 84 wherein each R 8 is independently
- Embodiment 86 A compound of Embodiment 85 wherein R ⁇ is H, methyl, methoxy or hydroxy.
- Embodiment 87 A compound of Embodiment 50 wherein m is 0 or 1.
- Embodiment 88 A compound of Embodiment 87 wherein m is 0.
- Embodiment 89 A compound of Embodiment 50 wherein each R 9 is independently C 1 -C 3 alkyl, C 2 -C 3 alkenyl, C 2 -C 3 alkynyl, cyclopropyl, C 1 -C 3 haloalkyl, C 2 - C 3 haloalkenyl, C 2 -C 3 haloalkynyl, halocyclopropyl, halogen, cyano, nitro, hydroxy, C 2 -C 3 alkylcarbonyloxy, C 1 -C 2 alkoxy, C 1 -C 2 haloalkoxy, C 1 -C 2 alkylthio, C 1 -C 2 haloalkylthio, C 2 -C 3 alkoxyalkyl, C 2 -C 3 alkylcarbonyl, C 2 -C 3 alkoxycarbonyl, C 2 -C 3 alkylaminocarbonyl or C 3 -C 4 dialkylamin
- Embodiment 90 A compound of Embodiment 89 wherein each R 9 is independently C 1 -C 3 alkyl, cyclopropyl, C 1 -C 3 haloalkyl, halocyclopropyl, halogen, hydroxy, C 2 -C 3 alkylcarbonyloxy, C 1 -C 2 alkoxy or C 1 -C 2 haloalkoxy.
- Embodiment 91 A compound of Embodiment 90 wherein each R 9 is independently
- Embodiment 92 A compound of Embodiment 91 wherein each R 9 is independently methyl, F, Cl, Br, hydroxy or methoxy.
- Embodiment 93 A compound of Embodiment 50 wherein j is 0 or 1.
- Embodiment 94 A compound of Embodiment 93 wherein j is 0.
- Embodiment 95 A compound of Embodiment 50 wherein each R ⁇ is H or methyl.
- Embodiment 96 A compound of Formula 1 wherein Q is Q-I through Q-75 and Q-83 through Q-85 and Q has the orientation depicted above in Embodiment 50, and wherein R ⁇ has an orientation below the plane defined by the 3 non-hydrogen atoms attached to the carbon atom identified with the asterisk (*) (e.g., for Q-I,
- Embodiment 97 A compound of Embodiment 50 wherein each R 16 is independently C 1 -C 3 alkyl, C 2 -C 3 alkenyl, C 2 -C 3 alkynyl, cyclopropyl, C 1 -C 3 haloalkyl, C 2 - C 3 haloalkenyl, C 2 -C 3 haloalkynyl, halocyclopropyl, halogen, cyano, nitro, C 1 - C 2 alkoxy or C 1 -C 2 haloalkoxy; or a phenyl or benzyl ring, optionally substituted with up to 3 substituents selected from R 13 .
- Embodiment 98 Embodiment 98.
- R 16a is H, C 1 -C 3 alkyl, allyl, propargyl, cyclopropyl or C 1 -C 3 haloalkyl; or a phenyl or benzyl ring, optionally substituted with up to 3 substituents selected from R 13 .
- Embodiment 99 A compound of Embodiment 50 wherein when Q is Q-76, Q-77, Q-79, Q-80, Q-81, Q-82, Q-83, Q-84 or Q-85, then m is 0 or 1.
- Embodiment 100 A compound of Embodiment 99 wherein m is 1.
- Embodiment 101 A compound of Embodiment 50 wherein when Q is Q-78 and R 16a is other than H, then m is 0.
- Embodiment 102 A compound of Embodiment 50 wherein when Q is Q-78 and R 16a is H, then m is 1.
- Embodiment 103 A compound of Embodiment 50 wherein when Q is Q-78, then R 16a is other than H and m is 0.
- Embodiment Al A compound of Formula 1 wherein n is 0; R 1 is a phenyl or 5- or 6- membered heteroaromatic ring, optionally substituted with 1 to 2 substituents independently selected from R 4 ; and each R 4 is independently C 1 -Cg alkyl, C 2 - C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 1 -C 6 haloalkyl, C 2 -C 6 haloalkenyl, C 2 -C 6 haloalkynyl, C 3 -C 6 halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C 1 -C4 alkoxy, C 1 -C4 haloalkoxy, C 1 -C4 alkylthio, C 1 -C4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, C 1
- Embodiment A2 A compound of Embodiment Al wherein W 1 is O and W 2 is O.
- Embodiment A3 A compound of Embodiment A2 wherein A is CH 2 .
- Embodiment A4 A compound of Embodiment A3 wherein X is X 1 and X 2 .
- Embodiment A5. A compound of Embodiment A4 wherein G is G-I, G-2, G-15, G-26 or G-36.
- Embodiment A6 A compound of Embodiment A5 wherein G is unsubstituted.
- Embodiment A7 A compound of Embodiment A6 wherein Q is Q-I, Q-2, Q-8, Q-23 or Q-41 and Q a is H or C 1 -C 3 alkyl.
- Embodiment A8 A compound of Embodiment A7 wherein R 5 is C 1 -C 3 alkyl, R 6 is H-45, R 15 is H, and p is 0.
- Embodiment A9 A compound of Embodiment A7 wherein j is 0, m is 0 or 1, and R 8 is H, methyl, methoxy or hydroxy. Embodiment AlO. A compound of any one of Embodiments A8 and A9 wherein R 1 is
- Embodiment All A compound of Embodiment AlO wherein each R ⁇ is independently Cl, Br, methyl, ethyl, trifluoromethyl or methoxy.
- Embodiment A12. A compound of Embodiment All wherein Q is Q-I, Q a is methyl,
- R 5 is C 1 -C 2 alkyl
- R 15 is H
- the carbon atom to which R 5 and R 6 are attached is a stereocenter with the R configuration.
- Embodiment A13 A compound of Embodiment All wherein Q is Q-2, Q-8, Q-23 or Q-41, Q a is methyl, R 15 is H, and the carbon atom identified with the asterisk (*) is a stereocenter having a configuration described as R, provided that when m is
- R 8 is hydroxy or methoxy and the R 8 group is attached to the carbon adjacent to the carbon atom identified with an asterisk (*), then the carbon atom identified with the asterisk (*) is a stereocenter having a configuration described as S.
- Specific embodiments include compounds of Formula 1 selected from the group consisting of:
- X 1 and X is linked to the G thiazole ring at the 2 position of said thiazole ring.
- X 1 and X is linked to the G oxazole ring at the 2 position of said oxazole ring.
- X 1 and X is linked to the G oxazole ring at the 2 position of said oxazole ring.
- X 2 and X is linked to the G oxazole ring at the 2 position of said oxazole ring.
- embodiments of these compounds within Embodiments 1 through 11, Embodiments 14 through 35, Embodiment 41, Embodiments 59 through 82, Embodiment 96, Embodiments Al through A4, Embodiment A6, Embodiment A8 and Embodiments AlO through A12.
- This invention provides a fungicidal composition
- a fungicidal composition comprising a compound of Formula 1 (including all geometric and stereoisomers, N-oxides, and agriculturally suitable salts thereof), and at least one other fungicide.
- a compound of Formula 1 including all geometric and stereoisomers, N-oxides, and agriculturally suitable salts thereof
- at least one other fungicide are compositions comprising a compound corresponding to any of the compound embodiments describe above.
- This invention provides a fungicidal composition
- a fungicidal composition comprising a fungicidally effective amount of a compound of Formula 1 (including all geometric and stereoisomers, iV-oxides, and agriculturally suitable salts thereof), and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents.
- a compound of Formula 1 including all geometric and stereoisomers, iV-oxides, and agriculturally suitable salts thereof
- additional component selected from the group consisting of surfactants, solid diluents and liquid diluents.
- This invention provides a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed or seedling, a fungicidally effective amount of a compound of Formula 1 (including all geometric and stereoisomers, TV-oxides, and agriculturally suitable salts thereof).
- a compound of Formula 1 including all geometric and stereoisomers, TV-oxides, and agriculturally suitable salts thereof.
- embodiment of such methods are methods comprising applying a fungicidally effective amount of a compound corresponding to any of the compound embodiments describe above.
- the compounds are applied as compositions of this invention.
- the compounds of Formula 1 can be prepared by one or more of the following methods and variations as described in Schemes 1-22.
- the definitions of R 1 , R 2 , A, W 1 , W 2 , X, G, Q a , Q b and n in the compounds of Formulae 1-46 below are as defined above in the Summary of the Invention unless otherwise noted.
- Compounds of Formulae la-Ik are various subsets of the compounds of Formula 1.
- Compounds of Formulae 19a- 19b are various subsets of the compounds of Formula 19.
- Compounds of Formulae 23a, 26a and 27a are various subsets of the compounds of Formula 23, 26 and 27 respectively.
- compounds of Formula 1 can be prepared by coupling of an acid chloride of Formula 2 with an amine of Formula 3 in the presence of an acid scavenger to provide the compound of Formula Ia.
- Typical acid scavengers include amine bases such as triethylamine, diisopropylethylamine and pyridine.
- Other scavengers include hydroxides such as sodium and potassium hydroxide and carbonates such as sodium carbonate and potassium carbonate.
- polymer-supported acid scavengers such as polymer-bound diisopropylethylamine and polymer-bound N,N- dimethylaminopyridine.
- amides of Formula Ia can be converted to thioamides of Formula Ib using a variety of standard thiating reagents such as phosphorus pentasulfide or 2,4-bis(4-methoxyphenyl)-l,3-dithia-2,4-diphosphetane-2,4-disulfide (Lawesson's reagent).
- standard thiating reagents such as phosphorus pentasulfide or 2,4-bis(4-methoxyphenyl)-l,3-dithia-2,4-diphosphetane-2,4-disulfide (Lawesson's reagent).
- W 1 is O
- the conversion of W 2 from O to S may be accompanied by conversion of W 1 from O to S.
- the amines of Formula 3 are known or can be prepared by methods known to one skilled in the art.
- compounds of Formula Ic wherein A is methylene can be prepared by coupling of an acid chloride of Formula 5 with an amine of Formula 6 in the presence of an acid scavenger, as described for Scheme 1 above.
- Acid salts of the Formula 6 amines can also be used in this reaction, provided at least 2 equivalents of the acid scavenger is present, as known to one skilled in the art.
- Typical acids used to form salts with amines include hydrochloric acid, oxalic acid and trifluoroacetic acid.
- amides of Formula Ic can be converted to thioamides of Formula Id using a variety of standard thiating reagents such as phosphorus pentasulfide or 2,4-bis(4-methoxyphenyl)-l,3-dithia- 2,4-diphosphetane-2,4-disulfide (Lawesson's reagent).
- standard thiating reagents such as phosphorus pentasulfide or 2,4-bis(4-methoxyphenyl)-l,3-dithia- 2,4-diphosphetane-2,4-disulfide (Lawesson's reagent).
- compounds of Formula Ic can also be prepared by coupling of an acid of Formula 7 with an amine of Formula 6 (or its acid salt) in the presence of a dehydrative coupling reagent, analogous to the procedure described in Scheme 2 above.
- the acids of Formula 7 are known or can be prepared by methods known to one skilled in the art.
- R 1 CH 2 COOH where R 1 is a heteroaromatic ring linked through nitrogen can be prepared by reacting the corresponding R 1 H compound with a haloacetic acid or ester in the presence of base; see, for example, US Patent 4,084,955.
- Adapa Synthetic Communications 2003, 33, 59-63 and references sited therein; or from R 1 Br or R 1 I by palladium catalyzed coupling with t-butyl acetate or diethyl malonate followed by ester hydrolysis; see, for example, W. A. Moradi and S. L. Buchwald, J. Am. Chem. Soc. 2001, 123, 7996-8002 and J. F. Hartwig et al., J. Am. Chem. Soc. 2002, 124, 12557-12565.
- Certain compounds of Formula Ic where R 1 is a 5-membered nitrogen containing heteroaromatic ring linked through the nitrogen atom can be prepared by reaction of the parent heterocycle of Formula 8 and a haloacetamide of Formula 9 as shown in Scheme 5. The reaction is carried out in the presence of a base such as sodium hydride or potassium carbonate in a solvent such as tetrahydrofuran, iV,N-dimethylformamide or acetonitrile at 0 to 80 °C.
- a base such as sodium hydride or potassium carbonate
- a solvent such as tetrahydrofuran, iV,N-dimethylformamide or acetonitrile at 0 to 80 °C.
- the haloacetamide of Formula 9 can be prepared by the reaction of an amine of Formula 6 with a haloacetyl halide or a haloacetic acid or its anhydride, analogous to the amide-forming reactions described in Schemes 3 and 4, respectively.
- Compounds of Formula Ie and If can also be prepared by the reaction of an amine of Formula 11 with a carbamoyl or thiocarbamoyl chloride or imidazole of Formula 12 as shown in Scheme 7.
- Z 2 is chlorine
- the reaction is typically carried out in the presence of an acid scavenger.
- Typical acid scavengers include amine bases such as triethylamine, diisopropylethylamine and pyridine.
- Other scavengers include hydroxides such as sodium and potassium hydroxide and carbonates such as sodium carbonate and potassium carbonate.
- the carbamoyl or thiocarbamoyl chlorides of Formula 12 can be prepared from amines of Formula 6 by treatment with phosgene or thiophosgene, respectively, or their equivalents, while carbamoyl or thiocarbamoyl imidazoles of Formula 12 (wherein Z 2 is imidazol-1-yl) can be prepared from amines of Formula 6 by treatment with l,r-carbonyldiimidazole or l,r-thiocarbonyldiimidazole, respectively, according to general methods known to one skilled in the art.
- Certain compounds of Formula Ig where G is linked to the piperidine ring via a carbon atom can be prepared from compounds of Formula Ih by catalytic hydrogenation as shown in Scheme 8.
- Typical conditions involve exposing a compound of Formula Ih to hydrogen gas at a pressure of 14 to 100 psi (96 to 689 kPa), preferably 40 to 50 psi (276 to 345 kPa), in the presence of a metal catalyst such as palladium supported on an inert carrier such as activated carbon, in a weight ratio of 5 to 20 % of metal to carrier, suspended in a solvent such as ethanol at an ambient temperature.
- a metal catalyst such as palladium supported on an inert carrier such as activated carbon
- Certain compounds of Formula Ig where G is linked to the piperidine ring via a nitrogen atom can be prepared by displacement of an appropriate leaving group 7? on a piperidine of Formula 13 with a nitrogen-containing heterocycle of Formula 14 in the presence of a base as depicted in Scheme 9.
- Suitable bases include sodium hydride or potassium carbonate and the reaction is carried out in a solvent such as N, N- dimethylformamide or acetonitrile at 0 to 80 0 C.
- Suitable leaving groups in the piperidines of Formula 13 include bromine, iodine, mesylate (OMs, OS(O) 2 CH 3 ), triflate (OS(O) 2 CF 3 ) and the like, and can be prepared from the corresponding piperidine compounds of Formula 13 where Z 3 is OH, as known to one skilled in the art.
- compounds of Formula Ii can be converted to compounds of Formula Ij using a variety of standard thiating reagents such as phosphorus pentasulfide or 2,4-bis(4- methoxyphenyl)-l,3-dithia-2,4-diphosphetane-2,4-disulfide (Lawesson's reagent).
- a base such as potassium carbonate
- a solvent such as dimethylsulfoxide, iV,N-dimethylformamide or acetonitrile at O to 80 0 C.
- compounds of Formula Ii can be converted to compounds of Formula Ij using a variety of standard thiating reagents such as phosphorus pentasulfide or 2,4-bis(4- methoxyphenyl)-l,3-dithia-2,4-diphosphetane-2,4-disulfide (Lawesson's reagent).
- W 2 is O
- the acid compounds of Formula 4 can be prepared by saponification of the corresponding ester compounds of Formula 17 using an alkali metal hydroxide such as LiOH, NaOH or KOH usually in the presence of water along with a co-solvent such as tetrahydrofuran and/or methanol to aid solubility of the ester as shown in Scheme 11.
- the reaction is typically run at O to 60 0 C with the resultant carboxylate salt being converted to the free acid by addition of a slight excess of a mineral acid such as hydrochloric acid or sulfuric acid.
- the ester compounds of Formula 17 can be prepared from the amine compounds of Formula 18 by methods analogous to those described above for the preparation of compounds of Formula 1 as outlined in Scheme 12.
- the amine compounds of Formula 18 can be prepared from the protected amine compounds of Formula 19 where PG is an acid-labile amine protecting group such as a t- butoxycarbonyl (t-Boc) or a benzyloxycarbonyl (Cbz) group as shown in Scheme 13.
- PG is an acid-labile amine protecting group such as a t- butoxycarbonyl (t-Boc) or a benzyloxycarbonyl (Cbz) group as shown in Scheme 13.
- the protecting group is removed by treating with an acid such as trifluoroacetic acid or gaseous HCl in the presence of a solvent such as dichloromethane or dioxane.
- the amine can be isolated as its acid salt or converted in a subsequent step to the free amine by treatment with a base, as known to one skilled in the art.
- R 40 is C 1 -C 4 alkyl
- PG is an acid-labile protecting group
- the amines of Formula 6 can be prepared from the protected amines of Formula 20 where PG is an acid-labile amine protecting group such as a t-butoxycarbonyl (t-Boc) or a benzyloxycarbonyl (Cbz) group as depicted in Scheme 14 by methods analogous to those described above for the preparation of compounds of Formula 18 as outlined in Scheme 13.
- PG is an acid-labile amine protecting group such as a t-butoxycarbonyl (t-Boc) or a benzyloxycarbonyl (Cbz) group as depicted in Scheme 14 by methods analogous to those described above for the preparation of compounds of Formula 18 as outlined in Scheme 13.
- the protected amines of Formula 20 can be prepared from the acid or acid chloride compounds of Formula 21 by methods analogous to those described above for the preparation of compounds of Formula 1 as outlined in Scheme 15.
- the compounds of Formula 21 where R 41 is OH can be obtained from compounds of Formula 19 by saponification, analogous to methods described for Scheme 11.
- R 41 is Cl or OH; PG is an acid-labile protecting group.
- Z 5 is Br, I, OH, OMs, or OTf; W is O or S; and PG is an acid-labile protecting group such as ?-Boc or Cbz.
- the compounds of Formula 19a where G is linked to the tetrahydropyridine ring via a carbon atom can be prepared by reacting the cyclic boronates of Formula 30 with the heteroaromatic compounds of Formula 31 where Z 6 is a halogen, preferably Br or I, or a triflate group as shown in Scheme 16.
- the reaction is carried out in the presence of a catalytic amount of palladium such as PdC ⁇ dppf (PdC ⁇ -I 5 I'- bis(diphenylphosphino)ferrocene) and a base such as potassium acetate in a solvent such as dioxane at 80 to 100 0 C, similar to that reported for the coupling of boronates of Formula 30 with aryl halides and triflates by P. R. Eastwood, Tetrahedron Letters 2000, 41, 3705-3708.
- the use of palladium in the synthesis of heterocycles is well known; see, for example, J. J. Li and G. W.
- iV-linked analogs can be prepared from hydroxypiperidines and the appropriate heterocycle via a Mitsunobu reaction, for examples of reactions of this type see: J. Med. Chem. 2004, 47(27), 6921-6934.
- Preparation of the heterocycle esters are described in the following references: Synthesis 1990, 753-754; Synthesis 1995, 1491-1492; J. Het. Chem. 1993, 30(4), 865-872; Tetrahedron 1986, 42(8), 2351-2358; /. Het. Chem. 1988, 25(2), 651-654; and HeIv. Chem. Acta 1996, 79(2), 449- 453.
- the compound of Formula 46 can also be prepared from the iV-benzyl hydrazino piperidine of Formula 27a as shown in Scheme 20; see, for example, Bioorganic & Medicinal Chemistry Letters 1999, 9(9), 1285-1290 and J. Ret. Chem., 1993, 30(4), 865- 872.
- the compound of Formula 37 can also be obtained by the route shown in Scheme 21 from the amino piperidine of Formula 23a; see, for example, Bioorganic & Medicinal Chemistry Letters 2001, 11(18), 2475-2479 and Organic Letters 2002, 4(23), 4133-4134.
- the compound of Formula 43 is also available from the 4-bromo piperidine of Formula 26a as shown in Scheme 22; see, for example, Bioorganic & Medicinal Chemistry Letters 1999, 9(9), 1285-1290, by initial conversion to the azide followed by cycloaddition with ethyl propiolate according to the general method of Organic Letters 2004, 6(23), 4223- 4225.
- Triethylamine (30 mL) was added, and the mixture was concentrated under reduced pressure, diluted with ethyl acetate, washed with brine, dried over magnesium sulfate and concentrated under reduced pressure to give 31 g of a brown oil, which solidified on standing. A portion of this crude product (8.1 g) was heated with 200 mL of ether, and the ether was then decanted. This was repeated a second time, and the combined ether solutions were evaporated under reduced pressure to give 7.6 g of the title compound as a yellow solid.
- Step C Preparation of ( ⁇ i?)- ⁇ -ethyl-N-methylbenzenemethanamine (alternatively named ( ⁇ ,i?)- ⁇ -ethyl-N-methylbenzenemethanamine)
- a solution of (/?)-(+)- 1-phenylpropylamine (9.19 g, 68.1 mmol) in 90 mL of dichloromethane was cooled to -30 0 C and treated with triethylamine (11.4 mL, 81.7 mmol) followed by dropwise addition of ethyl chloroformate (7.8 mL, 81.7 mmol).
- the reaction mixture was warmed to ambient temperature, stirred for 1 h, poured into 100 mL of 1 N aqueous hydrochloric acid and extracted with dichloromethane. The extract was washed with saturated aqueous sodium bicarbonate solution, dried over MgSC ⁇ and concentrated under reduced pressure to give 14.2 g of a colorless oil.
- the oil was dissolved in 15 mL of tetrahydrofuran and added dropwise to a suspension of lithium aluminum hydride (7.82 g, 206 mmol) in 25 mL of tetrahydrofuran that had been cooled to 0 0 C.
- Step F Preparation of 2-[l-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]-iV-methyl- ⁇ ' r -
- Step B Preparation of 7V-methyl-2-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl] acetyl] -4-piperidinyl] -N- [( Ii?)- 1 -phenylpropyl] -4-thiazolecarboxamide N-Methyl-N-[(li?)-l-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide (i.e. the product of Example 1, Step E) (150 mg, 0.44 mmol) was dissolved in 3 mL of dry dichloromethane.
- the dichloromethane/hexanes/ethyl acetate solution was concentrated under reduced pressure, and the residue was purified by preparative reverse phase High Pressure Liquid Chromatography (HPLC) using a solvent gradient going from 100 % water to 100 % acetonitrile to give 85 mg of the title product, a compound of the present invention as an oil.
- HPLC High Pressure Liquid Chromatography
- Step B Preparation of 2-[l-[(2,5-dichlorophenyl)acetyl]-4 ⁇ piperidinyl]- ⁇ L methyl-iV- [(li?)-l-phenylpropyl]-4-thiazolecarboxamide iV-Methyl-iY-[(li?)-l-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide (i.e. the product of Example 1, Step E) (171 mg, 0.5 mmol) was dissolved in 3 mL of dry dichloromethane.
- thiazolecarboxylate 2.0 g, 9.0 mmol
- diazabicycloundecene 1.5 mL, 10 mmol
- a catalytic amount of potassium iodide 2 mg
- Step C Preparation of 1,1-dimethylethyl 4-[5-[[memyl[(li?)-l-phenylethyl]amino ⁇ - carbonyl]-2-thiazolyl]-l-piperazinecarboxylate
- Step B Preparation of iV-methyl-2-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-N-[(l/?)-l-phenylethyl]-4-thiazolecarboxamide
- the resulting formamide (4.54 g, 26 mmol) was dissolved in 50 mL of tetrahydrofuran and added dropwise to a suspension of lithium aluminum hydride (1.1 g, 29 mmol) in 20 mL of tetrahydrofuran that had been cooled to 0 °C.
- the reaction mixture was refluxed overnight, then cooled to 0 0 C and quenched by the sequential addition of 1.1 mL of water, 1.1 mL of 15 % aqueous NaOH solution and 3.3 mL of water.
- the mixture was stirred at ambient temperature for 30 minutes and diluted with ethyl acetate.
- Step B Preparation of 1,1-dimethylethyl 4-[4-[(methyl[(li?)-l,2,3,4-tetrahydro-l- naphthalenyl]amino]carbonyl]-2-thiazolyl]-l-piperidinecarboxylate A mixture of 1 -(1,1-dimethylethyl) 4-[4-carboxy-2-thiazolyl]-l-piperidinecarboxylate
- the reaction mixture was diluted with 20 mL of dichloromethane, washed with 1 N aqueous hydrochloric acid, water, saturated aqueous sodium bicarbonate solution, water and brine, dried over MgSC>4 and concentrated under reduced pressure.
- the residue was purified by silica gel chromatography using 20 % to 100 % of ethyl acetate in hexanes to give 2.4 g of the title compound as an oil.
- Step C Preparation of N-methyl-2-(4-piperidinyl)-N- [(Ii?)- 1,2,3 ,4-tetrahydro-l - naphthalenyl]-4-thiazolecarboxamide monohydrochloride 1,1-Dimethylethyl 4-[4-[(methyl[(li?)-l ,2,3,4-tetrahydro-l-naphthalenyl]amino]- carbonyl] ⁇ 2-thiazolyl]-l-piperidinecarboxylate (i.e.
- Step D General preparation of 2-[l-[(substituted-phenyl)acetyl]-4-pi ⁇ eridinyl]-iV- methyl-iV-[(li?)-l,2,3,4-tetrahydro-l-naphthalenyl]-4-thiazolecarboxamide and N-methyl-2-[l-[[substituted-lH-pyrazol-l-yl]acetyl]-4- ⁇ i ⁇ eridinyl]-iV- [(li?)-l,2,3,4-tetrahydro-l-naphthalenyl]-4-thiazolecarboxamide
- DL-Serine methyl ester hydrochloride (3.89 g, 25 mmol) was added, and the reaction mixture was stirred at room temperature for 16 h.
- the reaction mixture was partitioned between 1 N aqueous hydrochloric acid and dichloromethane, and the organic layer was washed with 1 N aqueous hydrochloric acid, water and brine, dried over MgS ⁇ 4 and concentrated under reduced pressure to give 6.58 g of the title compound.
- Step B Preparation of 1,1-dimethylethyl 4-[4,5-dihydro-4-(methoxycarbonyl)-2- oxazolyl]-l -piperidinecarboxylate
- reaction mixture was stirred until homogeneous, and 4.59 g (29.87 mmol) of carbon tetrachloride was added dropwise over 5 minutes.
- the reaction mixture was stirred for 2.5 h at room temperature, cooled to 0 0 C and diluted with 170 mL of ethyl acetate followed by 50 mL of saturated aqueous sodium bicarbonate solution.
- the mixture was stirred for 10 minutes, poured into 120 mL of water, and the organic layer was separated, washed with brine, dried over MgS ⁇ 4 and concentrated under reduced pressure to give a yellow oil.
- the oil was purified by silica gel chromatography using 75-100 % ethyl acetate in hexanes as eluant to give 2.95 g of the title compound as an oil containing traces of triphenylphosphine.
- Step D Preparation of l-(l,l-dimethylethyl) 4-(4-carboxy-2-oxazolyl)-l-piperidine- carboxylate
- the mixture was diluted with saturated sodium chloride solution (10 mL), 30 mL of diethyl ether was added and the aqueous phase was acidified to pH 3-4 by dropwise addition of 20 % citric acid solution. The precipitated solid was filtered and dried to give 1.21 g of the title compound.
- Step E Preparation of 1,1-dimethylethyl 4-[4-[[methyl[(li?)-l-phenyl ⁇ ro ⁇ yl]amino]- carbonyl] -2-oxazolyl] - 1 -piperidinecarboxylate A mixture of l-( 1,1 -dimethylethyl) 4-(4-carboxy-2-oxazolyl)-l-piperidinecarboxylate
- the reaction mixture was poured into 4 mL of 1 N aqueous hydrochloric acid, and the organic layer was washed with 1 N aqueous hydrochloric acid, water and brine, dried (MgSO 4 ) and concentrated under reduced pressure.
- the residue was purified by silica gel chromatography using 25-75 % of ethyl acetate in hexanes as eluant to give 209 mg of the title compound as an oil.
- Step F Preparation of iV-methyl-2-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl3acetyl]-4-piperidinyl]-N-[(lig)-l-phenylpropyl]-4-oxazolecarboxamide
- Step B Preparation of iV-methyl-2-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-N-[(12?)-l,2,3,4-tetrahydro-l-naphthalenyl]-4- oxazolecarboxamide
- Step B Preparation of l-[(2,5-dimethylphenyl)acetyl]-4-piperidinecarboxylic acid Methyl l-[(2,5 ⁇ dimethylphenyl)acetyl]-4-piperidinecarboxylate (i.e. the product of
- Example 9 (4.95 g, 17.1 mmol) was dissolved in 20 niL of tetrahydrofuran, and 15 niL of water was added. With vigorous stirring the reaction mixture was cooled to 0 °C, and 35 mL of a 1 N aqueous sodium hydroxide solution was added dropwise. The reaction mixture was stirred at room temperature for 1 h, diluted with 20 mL of brine, washed with diethyl ether (3 x 20 mL), and the aqueous phase was acidified with 1 N aqueous hydrochloric acid to pH 3-4. The precipitate was collected and dried to give 4.08 g of the title compound.
- reaction mixture was stirred until homogeneous, and carbon tetrachloride (1.59 g, 10.32 mmol) was added dropwise over 5 minutes.
- the reaction mixture was stirred for 2.5 h at room temperature, cooled to 0 0 C and diluted with 50 mL of ethyl acetate followed by 15 mL of saturated aqueous sodium bicarbonate solution.
- the mixture was stirred for 10 minutes, poured into 40 mL of water, and the organic layer was separated, washed with brine, dried over MgS O4 and concentrated under reduced pressure to give 6 g of a yellow oil.
- the reaction mixture was washed with saturated aqueous ammonium chloride (2 x 50 mL), the aqueous phase was back- extracted with ethyl acetate (2 x 25 mL), and the combined organic layers were dried over MgS ⁇ 4 and concentrated under reduced pressure.
- the residue was purified by silica gel chromatography using 50-100 % of ethyl acetate in hexanes as eluant to give 600 mg of the title compound as an oil.
- Methyl 2-[l-[(2,5-dimethylphenyl)acetyl]-4-piperidinyl]-4-oxazolecarboxylate i.e. the product of Example 9, Step E
- 665 mg, 1.87 mmol was dissolved in 5 mL tetrahydrofuran, and 3.3 mL of water was added.
- the reaction mixture was cooled to 0 0 C with vigorous stirring.
- a l N aqueous sodium hydroxide solution (3.7 mL) was added dropwise, and the reaction mixture was stirred at room temperature for 2 h.
- the reaction mixture was stirred at room temperature overnight, diluted with ethyl acetate, washed with 1 N aqueous sodium hydroxide and brine, dried (MgSO 4 ), filtered and concentrated.
- the crude product was purified by silica gel medium pressure liquid chromatography using ethyl acetate/methanol as eluant to provide 80 mg of the title product, a compound of the present invention as a viscous oil.
- Step B Preparation of 3 -chloro- ⁇ iV-dimethyl-lH-pyrazole-l -sulfonamide
- Step C Preparation of 3,5-dichloro-N,N-dimethyl-lH-pyrazole-l-sulfonamide Under a nitrogen atmosphere, a solution of 3-chloro-iV,iV-dimethyl-lH-pyrazole-l- sulfonamide (1.68 g, 8 mmol) (i.e. the product of Example 12, Step B) in tetrahydrofuran (10 mL) was cooled to -78 °C and then treated with a solution of 2 M n-butyllithium in cyclohexane (4.5 mL, 9 mmol) dropwise. The solution formed a thick precipitate and was allowed to stir for 30 minutes after the addition.
- Step F Preparation of 3, 5-dichloro-lH-pyrazol-l -acetic acid A solution of ethyl 3, 5-dichloro-lH-pyrazole-l -acetate (1.29 g, 5.8 mmol) (i.e. the product of Example 12, Step E) in tetrahydrofuran (10 mL) was treated with sodium hydroxide (5 mL, 15 % aqueous solution) in water (3 mL), and the reaction mixture was stirred at ambient temperature for 1.5 h.
- Step G Preparation of 2-[l-[(3,5-dichloro-lH-pyrazol-l-yl)acetyl]-4-piperidinyl]-N- methyl-iV-[(li?)-l,2,3,4-tetrahydro-l-naphthalenyl]-4-thiazolecarboxamide
- a solution of 3, 5-dichloro-lH-pyrazol-l -acetic acid 70 mg, 0.36 mmol
- Step B Preparation of 5-chloro-iV,iV-dimethyl-3-(trifluoroniethyl)-lH-pyrazole-l- sulfonamide
- Step D Preparation of ethyl 5-chloro-3-(trifluoromethyl)-lH-pyrazole-l-acetate
- Step F Preparation of 2-[l-[[5-chloro-3-(trifluoromethyl)-lH-pyrazol-l-yl]acetyl]-4- piperidinyl]-iV r -methyl-N-[(l J R)-l,2,3,4-tetrahydro-l-naphthalenyl]-4- thiazolecarboxamide
- a solution of 5-chloro-3-(trifluoromethyl)-lH-pyrazole-l-acetic acid 140 mg, 0.61 mmol
- Step A Preparation of 3,5-bis-(trifluoromethyl)-lH-pyrazole-l-acetic acid
- a solution of 3,5-bis-(trifluoromethyl) ⁇ yrazole (1.0 g, 4.90 mmol) in iV,iV-dimethyl- formamide (10 mL) at 0 0 C was treated with sodium hydride (60 % dispersion in oil, 215 mg, 5.37 mmol) and the reaction mixture was allowed to stir at room temperature for 1 h.
- a solution of ethyl iodoacetate (2.0 g, 9.30 mmol) in iV,N-dimethylformamide (10 mL) was then added and the reaction mixture heated at 80 0 C for 24 h.
- the reaction mixture was then cooled to room temperature, diluted with ethyl acetate and washed with water. The organic layer was dried with MgSC ⁇ , filtered and concentrated to provide 570 mg of the crude ester.
- the crude ester was dissolved in tetrahydrofuran (2 mL) and treated with sodium hydroxide (150 mg) in water (1.5 mL). The reaction mixture was then stirred at room temperature overnight. The resulting mixture was diluted with water (10 mL), extracted with diethyl ether (20 mL). The organic layers were dried with MgSO ⁇ filtered and concentrated in vacuo to provide 190 mg of the title compound. This compound was of sufficient purity to use in subsequent reactions.
- Step B Preparation of 2-[l-[[3,5-bis(trifluoromethyl)-lH-pyrazol-l-yl]acetyl]-4- piperidinyl]-JV-methyl-iV-[(l ⁇ )-l,2,3,4-tetrahydro-l-naphthalenyl]-4- thiazolecarboxamide
- Step D Preparation of 2-[l-[(3,5-diethyl-lH-pyrazol-l-yl)acetyl]-4-piperidinyl]-N- methyl-iV-[(li?)-l,2,3,4-tetrahydro-l-naphthalenyl]-4-thiazolecarboxamide
- a solution of 3,5-diethyl-lH-pyrazol-l-acetic acid (135mg, 0.74 mmol) (i.e.
- Step D Preparation of 2-[l-[[5-ethyl-3-(trifluoromethyl)-lH- ⁇ yrazol-l-yl]acetyl]-4- piperidinyl]-N-methyl-N-[(l/?)-l,2,3,4-tetrahydro-l-naphthalenyl]-4- thiazolecarboxamide
- reaction mixture was added to a stirred suspension of iV-methyl-2-(4-piperidinyl)- ⁇ T-[(ll?)-l,2,3,4- tetrahydro-l-naphthalenyl]-4-thiazolecarboxamide monohydrochloride (i.e. the product of Example 6 Step C) (219 mg, 0.56 mmol), triethylamine (0.5 mL, 3.75 mmol) in ethyl acetate (5 mL). The reaction mixture was then stirred at room temperature for 12 h. The resulting suspension was concentrated in vacuo and purified by silica gel MPLC using ethyl acetate/hexanes as eluant to give 200 mg of the title product, a compound of the present invention as an oil.
- Step A Preparation of 1,1-dimethylethyl [(lS)-l-(hydroxymethyl)-2-[methyl[(li?)- 1 ,2,3 ,4-tetrahydro- 1 -naphthalenyl] amino] -2-oxoethyl] carbamate
- the precipitate formed was filtered and washed with tetrahydrofuran.
- the filtrate and washings were concentrated, and the residue was purified by medium-pressure liquid chromatography using a gradient of 50-100 % of ethyl acetate in hexanes as eluant to give 1.11 g of the title compound.
- Step C Preparation of ethyl l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4 ⁇ piperidinylcarboxylate
- step B) in 5 mL of dichloromethane was added dropwise with stirring.
- the reaction mixture was allowed to warm to room temperature and stirred for 16 h.
- the reaction mixture was poured in 50 mL of water, and the organic layer was subsequently washed with water, 1
- Step D Preparation of l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]acetyl]-4- piperidinylcarboxylic acid
- Step E Preparation of N-[(15)-l-(hydroxymethyl)-2-[methyl[(17?)-l,2,3,4-tetrahydro- l-naphthalenyl]amino]-2-oxoethyl]-l-[[5-methyl-3-(trifluoromethyl)-lH- pyrazol- 1 -yl] acetyl] -4-piperidinecarboxamide
- Example 17 Step B) and iV-methylmorpholine (222.53 mg, 2.2 mmol) in 8 mL of tetrahydrofuran was cooled to 0 0 C and l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinylcarboxylic acid (638.56 mg, 2 mmol) (i.e. the product of Example 17,
- Step D) was added followed by iV-hydroxybenzotriazole (27 mg, 0.2 mmol) and N,N- diisopropylcarbodiimide (265 mg, 2.1 mmol).
- the reaction mixture was stirred for 16 h at room temperature and filtered.
- the precipitate was washed with tetrahydrofuran and the resulting filtrate and washings were concentrated in vacuo.
- the residue was dissolved in dichloromethane and the resulting solution was washed with water, 1 M aqueous hydrochloric acid, water, saturated aqueous solution of sodium bicarbonate and brine, dried over MgSO 4 and concentrated in vacuo.
- the resulting product was purified by medium- pressure liquid chromatography on silica gel using 0-20 % methanol in ethyl acetate as eluant to give 600 mg of the title compound as a white solid.
- Step F Preparation of N-methyl-2-[l-[[5-memyl-3-(trifluoromethyl)-lH-pyrazol ⁇ l- yl]acetyl]-4-piperidinyl]-iV-[(li?)-l,2,3,4-tetrahydro-l-naphthalenyl]-4- oxazolinecarboxamide
- Step D Preparation of Methyl l-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-lH-pyrazole-3-carboxylate
- reaction mixture was poured in water, the organic layer was washed with 1 M aqueous hydrochloric acid, water, saturated aqueous solution of sodium bicarbonate, brine. The filtered reaction mixture was dried over magnesium sulfate and concentrated in vacuo to give 320 mg of the title compound.
- Step F Preparation of iV-methyl-l-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-N-[(l/?)-l,2,3,4-tetrahydro-l-naphthalenyl]-lH- pyrazole-3 -c arboxamide
- the reaction mixture was poured in water, and the organic layer was subsequently washed with water, 1 M aqueous hydrochloric acid, water, saturated aqueous solution of sodium bicarbonate, brine.
- the filtered reaction mixture was dried over magnesium sulfate and evaporated in vacuo.
- the crude product was purified by medium-pressure liquid chromatography on silica gel using 75-100 % of ethyl acetate in hexanes as eluant to give 55 mg of the title compound, a compound of the present invention as an oil.
- Step B Preparation of ethyl-2-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-4-thiazolecarboxylate
- reaction mixture was allowed to warm to room temperature and stirred overnight.
- the reaction mixture was poured into water and extracted with dichloromethane.
- the extract was washed with 1 M aqueous hydrochloric acid, water, saturated aqueous solution of sodium bicarbonate, and brine.
- the filtered mixture was dried (MgSC ⁇ ) and evaporated in vacuo to give 13.0 g of the title compound as an oil.
- Step C Preparation of 2-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]acetyl]- 4-piperidinyl]-4-thiazolecarboxylic acid
- Step E Preparation of N-[(li?)-2,3-dihydro-lH-inden-l-yl]-iV-methyl-2-[l-[[5- methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]acetyl]-4-piperidinyl]-4- thiazolecarboxamide
- the reaction mixture was stirred at room temperature for 2 h, passed through a Varian 1005 Chem Elut TM column pretreated with 3 mL of 1 N aqueous hydrochloric acid. The column was flushed with three column volumes of dichloromethane. The collected dichloromethane solution was evaporated in vacuo and purified by medium-pressure liquid chromatography on silica gel using 50-100 % of ethyl acetate in 1-chlorobutane as eluant to give 214 mg of the title compound, the product of present invention as a white foam.
- reaction mixture was stirred at room temperature for 16 h, diluted with 4 mL of dichloromethane, and washed with water, 1 N aqueous hydrochloric acid, water, saturated solution of sodium bicarbonate and brine.
- the filtered reaction mixture was dried over magnesium sulfate and concentrated in vacuo to give 300 mg of the title compound, the product of present invention as a white foam.
- the reaction mixture was stirred at room temperature for 16 h, diluted with 2 mL of dichloromethane, and washed with water, 1 N aqueous hydrochloric acid, water, saturated solution of sodium bicarbonate and brine.
- the filtered reaction mixture was dried over sodium sulfate and concentrated in vacuo.
- the crude product was purified by medium-pressure liquid chromatography on silica gel using 60-100 % of ethyl acetate in hexanes as eluant to give 70 mg of the title compound, a compound of the present invention as white foam.
- the reaction mixture was stirred at room temperature for 16 h, poured into 100 mL of 1 M aqueous hydrochloric acid, and filtered.
- the filtered aqueous layer was washed with dichloromethane, basified with NaOH pellets to p ⁇ 13, and then extracted with dichloromethane.
- the extract was washed with brine, dried over magnesium sulfate and evaporated in vacuo to give a gummy yellow solid.
- the solid was slurried in diethyl ether, filtered, washed with diethyl ether and air dried to give 2.15 g of the title compounds as white powder.
- Step B Preparation of iV-methyl-2-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-N-[(lR,45)-l,2,3,4-tetrahydro-4-hydroxy-l- naphthalenyl]-4-thiazolecarboxamide and its enantiomer
- the reaction mixture was stirred at room temperature for 1 h, diluted with dichloromethane, and washed with water, 1 N aqueous hydrochloric acid, water, saturated solution of sodium bicarbonate and brine.
- the filtered reaction mixture was dried over magnesium sulfate and concentrated in vacuo.
- the crude product was purified by medium-pressure liquid chromatography on silica gel using 0- 20 % of acetone in ethyl acetate as eluant to give 700 mg of the title compounds, compounds of the present invention as an off-white powder.
- reaction mixture was filtered through Celite® diatomaceous filter aid, and purified by medium-pressure liquid chromatography on silica gel using 20 % acetone in ethyl acetate as eluant to give 70 mg of the title compound, a compound of the present invention as a white foam.
- the resulting residue was diluted with diethyl ether and allowed to stand at room temperature for 16 h.
- the precipitate formed was filtered, the filtrate was washed with saturated aqueous solution of sodium bicarbonate, dried over magnesium sulfate and concentrated under reduced pressure.
- the reaction residue was diluted with diethyl ether and extracted with 1 N aqueous hydrochloric acid.
- the aqueous extract was basified with 50 % aqueous solution of sodium hydroxide to p ⁇ 9 and immediately extracted with diethyl ether.
- the organic extract was dried (MgSC ⁇ ) and concentrated to give 390 mg of inverted acetates, (li?,47?)- 1,2,3, 4-tetrahydro-4- (methylamino)-l-naphthalenyl acetate and its enantiomer.
- the acetate and its enantiomer were shaken for 6 h at room temperature with 2 g of Bio-Rad AG1-X2 (O ⁇ ⁇ ) resin.
- the resin was filtered, the filtrate was evaporated in vacuo and the resulting residue was diluted with diethyl ether and extracted with 1 N aqueous hydrochloric acid.
- the acidic extract was basified with 50 % aqueous solution of sodium hydroxide and extracted with dichloromethane.
- Step B Preparation of N-methyl-2-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-iV-[(ljR,4i?)-l,2,3,4-tetrahydro-4-hydroxy-l- naphthalenyl]-4-thiazolecarboxamide and its enantiomer
- a solution of (l/?,4/?)-l,2,3,4-tetrahydro-4-(methylamino)-l-naphthalenol and its enantiomer 70 mg, 0.39 mmol
- the filtered reaction mixture was dried over magnesium sulfate and concentrated in vacuo.
- the crude product was purified by medium-pressure liquid chromatography on silica gel using 0-20 % of acetone in ethyl acetate as eluant to give 160 mg of the title compounds, compounds of the present invention as a white foam.
- Step A Preparation of 1,1-dimethylethyl 4-[4-(ethoxycarbonyl)-2-thiazoIyl]-l- piperazinecarboxylate
- 1,1-Dimethylethyl 1 -piperazinecarboxylate (1.86 g, 10 mmol), methyl 2-chloro-5- thiazolecarboxylate (1.92 g, 10.0 mmol), diazabicycloundecene (1.5 mL, 10 mmol) and a catalytic amount of potassium iodide (2 mg) were dissolved in 10 mL of dry dimethylsulfoxide and warmed to 80 0 C for 16 h. The warm solution was added dropwise with stirring to 200 mL of cold water. The reaction mixture was extracted with diethyl ether.
- Step B Preparation of ethyl 2-(l-piperazinyl)-4-thiazolecarboxylate monohydrochloride
- Step C Preparation of ethyl-2-[4-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl] acetyl] - 1 -piperazinyl] -4-thiazolecarboxylate
- Step D Preparation of 2-[4-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl]acetyl]-l- ⁇ iperazinyl]-4-thiazolecarboxylic acid
- Step A Preparation of 1,1-dimethylethyl 4-bromo-4-[4-(ethoxycarbonyl)-2- thiazolyl] - 1 -piperidinecarboxylate
- reaction mixture was then cooled, filtered, concentrated in vacuo, and purified by medium-pressure liquid chromatography on silica gel using 0-20 % of ethyl acetate in 1-chlorobutane as eluant to give 1.9 g of the title compound as an oil.
- Step D Preparation of ethyl 2-[l,2,3,6-tetrahydro-l-[[5-methyl-3-(trifluoromethyl)- lH-pyrazol-l-yl]acetyl]-4-pyridinyl]-4-thiazolecarboxylate 5-Methyl-3-(trifluoromethyl)-lH-pyrazole-l -acetyl chloride (1.05 g, 2.5 mmol).
- the reaction mixture was diluted with dichloromethane, washed with 1 N aqueous hydrochloric acid, water, saturated aqueous solution of sodium bicarbonate and brine, and dried over magnesium sulfate. The filtered residue was evaporated in vacuo to give 1.0 g of a white foam.
- the resulting foam was purified by medium-pressure liquid chromatography on silica gel eluting with 0-50 % ethyl acetate in 1-chlorobutane to give 0.67 g of the title compound as a yellow oil which solidified on standing.
- Step A Preparation of 1,1-dimethylethyl 4-[4-(ethoxycarbonyl)-2H-l,2,3-triazol-2- yl]-l-piperidinecarboxylate
- Step B Preparation of ethyl 2-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-2H-l,2,3-triazole-4-carboxylate
- Trifluoroacetic acid (3 mL) was added to 1,1-dimethylethyl 4-[4-(ethoxycarbonyl)- 2H-l,2,3-triazol-2-yl]-l- ⁇ iperidinecarboxylate (0.41 g, 1.3 mmol) (i.e. the product of Example 32, Step A).
- the reaction mixture was stirred for 45 minutes.
- the reaction mixture was then concentrated in vacuo.
- the resulting mixture was treated with saturated aqueous sodium bicarbonate and the aqueous layer was extracted three times with dichloromethane.
- reaction mixture was then added to a solution of ethyl 4-piperidinyl ⁇ 2H-l,2,3-triazole-4 ⁇ carboxylate (0.23 g) and triethylamine (0.20 mL, 1.4 mmol) in dichloromethane (10 mL) at 0 0 C.
- the reaction mixture was stirred at room temperature overnight.
- the organic layer was washed with saturated aqueous sodium bicarbonate, dried (Na2SO4) and the solvent was removed with a rotary evaporator.
- the residue was purified by medium pressure liquid chromatography (MPLC) using 35 to 60 % ethyl acetate in hexanes as eluant to afford 0.35 g of the title compound as a white solid.
- MPLC medium pressure liquid chromatography
- the aqueous layer was washed with diethyl ether and the aqueous layer was acidified with concentrated hydrochloric acid to p ⁇ 1, and extracted with dichloromethane and then chloroform. The combined organic layers were dried (Na 2 SC ⁇ ) and concentrated in vacuo to afford 0.27 g of the title compound as a white solid.
- Step D Preparation of iV-metriyl-2-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4- ⁇ iperidinyl]-N-[(li?)-l,2,3,4-tetrahydro-l-naphthalenyl]-2H- 1 ,2,3-triazole-4-carboxamide
- Step B Preparation of ethyl l-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl] acetyl] -4-piperidinyl] - lH-pyrazole-4-carboxylate
- Step B 1,1-dimethylethyl 4-[4-
- This amine was reacted with the acid chloride formed from 5-methyl-3-(trifluoromethyl)-lH-pyrazole-l-acetic acid (0.18 g, 0.88 mmol) and oxalyl chloride (0.10 mL, 1.15 mmol) in the presence of triethylamine (0.16 mL, 1.15 mmol) to afford 0.24 g of the title compound as a white solid.
- Step C Preparation of l-[l-[[5-methyI-3-(trifluoromethyl)-lH-pyrazol-l-yl]acetyl]-4- piperidinyl]-lH-pyrazole-4-carboxylic acid
- Step D Preparation of iV-methyl-l-[l-[[5-methyl-3-(trifluoromethyl)-lH-pyrazol-l- yl]acetyl]-4-piperidinyl]-iV-[(l/?)-l,2,3,4-tetrahydro-l-naphthalenyl]-lH- pyrazole-4-carboxamide
- Step D l-[l-[[5-methyl-3-
- the invention includes but is not limited to the following exemplary species.
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Abstract
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US11/988,359 US8586611B2 (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides |
PL06800387T PL1948649T3 (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides |
ES06800387T ES2427153T3 (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides |
MX2008001077A MX2008001077A (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides. |
CA002614288A CA2614288A1 (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides |
EP06800387.0A EP1948649B1 (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides |
NZ564017A NZ564017A (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides |
JP2008524143A JP5049276B2 (en) | 2005-07-26 | 2006-07-26 | Bactericidal carboxamide |
AU2006272551A AU2006272551B2 (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides |
RSP-2008/0027A RS20080027A (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides |
KR1020087002106A KR101332900B1 (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides |
BRPI0615957-5A BRPI0615957A2 (en) | 2005-07-26 | 2006-07-26 | compounds, method of controlling plant diseases and fungicidal compositions |
CN2006800271007A CN101228156B (en) | 2005-07-26 | 2006-07-26 | Fungicidal carboxamides |
IL187868A IL187868A0 (en) | 2005-07-26 | 2007-12-03 | Fungicidal carboxamides |
EC2008008112A ECSP088112A (en) | 2005-07-26 | 2008-01-17 | FUNGICIDE CARBOXAMIDS |
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Cited By (106)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2008091594A2 (en) * | 2007-01-24 | 2008-07-31 | E. I. Du Pont De Nemours And Company | Fungicidal mixtures |
WO2008091580A3 (en) * | 2007-01-25 | 2008-09-12 | Du Pont | Fungicidal amides |
EP1996583A1 (en) * | 2006-03-15 | 2008-12-03 | 4Sc Ag | Thiazoles as nf-kb inhibitors (proteasome inhibitors) |
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PL1948649T3 (en) | 2013-11-29 |
MX2008001077A (en) | 2008-03-19 |
ZA200711055B (en) | 2009-08-26 |
UY29695A1 (en) | 2007-02-28 |
IL187868A0 (en) | 2008-03-20 |
NZ564017A (en) | 2010-01-29 |
AU2006272551B2 (en) | 2012-06-14 |
EP1948649B1 (en) | 2013-06-26 |
WO2007014290A3 (en) | 2007-06-07 |
RU2008106955A (en) | 2009-09-10 |
JP2009502948A (en) | 2009-01-29 |
US20110269712A1 (en) | 2011-11-03 |
ES2427153T3 (en) | 2013-10-29 |
EP1948649A2 (en) | 2008-07-30 |
BRPI0615957A2 (en) | 2011-05-31 |
US8586611B2 (en) | 2013-11-19 |
RS20080027A (en) | 2009-07-15 |
TW200738701A (en) | 2007-10-16 |
CN101228156B (en) | 2012-07-18 |
CA2614288A1 (en) | 2007-02-01 |
TNSN08041A1 (en) | 2009-07-14 |
JP5049276B2 (en) | 2012-10-17 |
AR057688A1 (en) | 2007-12-12 |
KR101332900B1 (en) | 2013-11-27 |
GT200600329A (en) | 2007-03-26 |
WO2007014290B1 (en) | 2007-08-09 |
PE20070370A1 (en) | 2007-05-11 |
ECSP088112A (en) | 2008-02-20 |
CN101228156A (en) | 2008-07-23 |
KR20080031030A (en) | 2008-04-07 |
MA29621B1 (en) | 2008-07-01 |
AU2006272551A1 (en) | 2007-02-01 |
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