WO2007008937A8 - Adiponectin variants - Google Patents

Adiponectin variants

Info

Publication number
WO2007008937A8
WO2007008937A8 PCT/US2006/026971 US2006026971W WO2007008937A8 WO 2007008937 A8 WO2007008937 A8 WO 2007008937A8 US 2006026971 W US2006026971 W US 2006026971W WO 2007008937 A8 WO2007008937 A8 WO 2007008937A8
Authority
WO
WIPO (PCT)
Prior art keywords
adiponectin
variant
relative
seq
adiponectin variants
Prior art date
Application number
PCT/US2006/026971
Other languages
French (fr)
Other versions
WO2007008937A3 (en
WO2007008937A2 (en
Inventor
Jonathan Zalevsky
Duc-Hanh Thi Nguyen
Gregory L Moore
Sergei A Ezhevsky
John R Desjarlais
Arthur J Chirino
Darian Cash
Matthew J Bernett
Original Assignee
Xencor Inc
Jonathan Zalevsky
Duc-Hanh Thi Nguyen
Gregory L Moore
Sergei A Ezhevsky
John R Desjarlais
Arthur J Chirino
Darian Cash
Matthew J Bernett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2006/000627 external-priority patent/WO2006074432A2/en
Priority claimed from US11/421,059 external-priority patent/US7709607B2/en
Priority claimed from US11/421,062 external-priority patent/US20070054359A1/en
Priority claimed from US11/421,055 external-priority patent/US7592423B2/en
Priority claimed from US11/421,060 external-priority patent/US7749956B2/en
Priority claimed from US11/421,061 external-priority patent/US7678886B2/en
Application filed by Xencor Inc, Jonathan Zalevsky, Duc-Hanh Thi Nguyen, Gregory L Moore, Sergei A Ezhevsky, John R Desjarlais, Arthur J Chirino, Darian Cash, Matthew J Bernett filed Critical Xencor Inc
Publication of WO2007008937A2 publication Critical patent/WO2007008937A2/en
Publication of WO2007008937A8 publication Critical patent/WO2007008937A8/en
Publication of WO2007008937A3 publication Critical patent/WO2007008937A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

An adiponectin variant comprising one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of said variant is improved by at least 3-fold relative to residues 110-244 of SEQ ID NO:1 (human adiponectin). Said adiponectin variant may not comprise residues 1-100 relative to SEQ ID NO:1.
PCT/US2006/026971 2005-07-11 2006-07-11 Adiponectin variants WO2007008937A2 (en)

Applications Claiming Priority (26)

Application Number Priority Date Filing Date Title
US69835805P 2005-07-11 2005-07-11
US60/698,358 2005-07-11
US72076805P 2005-09-26 2005-09-26
US60/720,768 2005-09-26
US73313705P 2005-11-02 2005-11-02
US60/733,137 2005-11-02
US11/328,901 2006-01-09
PCT/US2006/000627 WO2006074432A2 (en) 2005-01-07 2006-01-09 Adiponectin variants
US11/328,901 US20070015909A1 (en) 2005-01-07 2006-01-09 Adiponectin variants
USPCT/US2006/000627 2006-01-09
US77782506P 2006-03-01 2006-03-01
US60/777,825 2006-03-01
US78150906P 2006-03-09 2006-03-09
US60/781,509 2006-03-09
US79022006P 2006-04-07 2006-04-07
US60/790,220 2006-04-07
US11/421,055 2006-05-30
US11/421,059 US7709607B2 (en) 2005-07-11 2006-05-30 Adiponectin variants
US11/421,060 2006-05-30
US11/421,062 US20070054359A1 (en) 2005-07-11 2006-05-30 Rational Chemical Modification of Adiponectin Variants
US11/421,062 2006-05-30
US11/421,055 US7592423B2 (en) 2005-01-07 2006-05-30 Globular adiponectin variants
US11/421,059 2006-05-30
US11/421,060 US7749956B2 (en) 2005-01-07 2006-05-30 Method of treatment using adiponectin variants
US11/421,061 US7678886B2 (en) 2005-01-07 2006-05-30 Pharmaceutical compositions of adiponectin variants and methods of storage
US11/421,061 2006-05-30

Publications (3)

Publication Number Publication Date
WO2007008937A2 WO2007008937A2 (en) 2007-01-18
WO2007008937A8 true WO2007008937A8 (en) 2007-04-12
WO2007008937A3 WO2007008937A3 (en) 2007-05-18

Family

ID=37637911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/026971 WO2007008937A2 (en) 2005-07-11 2006-07-11 Adiponectin variants

Country Status (1)

Country Link
WO (1) WO2007008937A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2020447A1 (en) 2007-08-03 2009-02-04 Zeltia, S.A. Method for identifying compounds modulating adiponectin gene expression
WO2009025300A1 (en) 2007-08-21 2009-02-26 Regenetiss Inc. Peptide capable of binding to immunoglobulin
CN102294021A (en) * 2011-07-28 2011-12-28 山西医科大学 Medicinal preparation for reducing blood sugar
CN103031323B (en) * 2011-09-30 2014-10-08 浙江大学宁波理工学院 Glutamate decarboxylase (GAD) thermally-stable variant G56P gene and application thereof
WO2013130676A1 (en) * 2012-02-29 2013-09-06 Ambrx, Inc. Modified adiponectin polypeptides and their uses
CN112521481B (en) * 2020-12-08 2022-11-04 武汉市工程科学技术研究院 Surface modifier and preparation method and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002358467A1 (en) * 2001-12-21 2003-07-15 Maxygen Aps Adiponectin fragments and conjugates
EP1756159A1 (en) * 2004-05-21 2007-02-28 Xencor, Inc. C1q family member proteins with altered immunogenicity

Also Published As

Publication number Publication date
WO2007008937A3 (en) 2007-05-18
WO2007008937A2 (en) 2007-01-18

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