WO2006136586A2 - N, n-bis- (2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs - Google Patents
N, n-bis- (2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs Download PDFInfo
- Publication number
- WO2006136586A2 WO2006136586A2 PCT/EP2006/063418 EP2006063418W WO2006136586A2 WO 2006136586 A2 WO2006136586 A2 WO 2006136586A2 EP 2006063418 W EP2006063418 W EP 2006063418W WO 2006136586 A2 WO2006136586 A2 WO 2006136586A2
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- WIPO (PCT)
- Prior art keywords
- substituted
- prodrug
- aryls
- group
- biologically active
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- 0 COC(*)(**)C(*)(*)N(C(*)(*)C(*)(*)O*)C(*)(*)C(*)=O Chemical compound COC(*)(**)C(*)(*)N(C(*)(*)C(*)(*)O*)C(*)(*)C(*)=O 0.000 description 6
- BZQQPYCROGLNNI-UHFFFAOYSA-N OCCNCC(CSCC(C(CSC(c1ccccc1)(c1ccccc1)c1ccccc1)O)O)O Chemical compound OCCNCC(CSCC(C(CSC(c1ccccc1)(c1ccccc1)c1ccccc1)O)O)O BZQQPYCROGLNNI-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES06777407T ES2390816T3 (en) | 2005-06-22 | 2006-06-21 | N, N-bis- (2-hydroxyethyl) glycine amide as a linker in polymer conjugated prodrugs |
JP2008517500A JP5121068B2 (en) | 2005-06-22 | 2006-06-21 | N, N-bis- (2-hydroxyethyl) glycinamide as a linker in polymer conjugated prodrugs |
SI200631452T SI1909845T1 (en) | 2005-06-22 | 2006-06-21 | N,n-bis-(2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs |
CN2006800305060A CN101242859B (en) | 2005-06-22 | 2006-06-21 | N,N-bis-(2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs |
EP06777407A EP1909845B1 (en) | 2005-06-22 | 2006-06-21 | N,n-bis-(2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs |
PL06777407T PL1909845T3 (en) | 2005-06-22 | 2006-06-21 | N,n-bis-(2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs |
US11/993,645 US8980242B2 (en) | 2005-06-22 | 2006-06-21 | Aliphatic prodrug linker |
MX2007016547A MX2007016547A (en) | 2005-06-22 | 2006-06-21 | N, n-bis- (2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs. |
AU2006260914A AU2006260914B2 (en) | 2005-06-22 | 2006-06-21 | N, N-bis- (2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs |
CA2613208A CA2613208C (en) | 2005-06-22 | 2006-06-21 | N, n-bis- (2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs |
BRPI0612536-0A BRPI0612536A2 (en) | 2005-06-22 | 2006-06-21 | aliphatic prodrug binding group |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0512705.5 | 2005-06-22 | ||
GB0512705A GB2427360A (en) | 2005-06-22 | 2005-06-22 | Aliphatic prodrug linker |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006136586A2 true WO2006136586A2 (en) | 2006-12-28 |
WO2006136586A3 WO2006136586A3 (en) | 2007-07-26 |
Family
ID=34855956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/063418 WO2006136586A2 (en) | 2005-06-22 | 2006-06-21 | N, n-bis- (2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs |
Country Status (14)
Country | Link |
---|---|
US (1) | US8980242B2 (en) |
EP (1) | EP1909845B1 (en) |
JP (1) | JP5121068B2 (en) |
CN (1) | CN101242859B (en) |
AU (1) | AU2006260914B2 (en) |
BR (1) | BRPI0612536A2 (en) |
CA (1) | CA2613208C (en) |
CY (1) | CY1113204T1 (en) |
ES (1) | ES2390816T3 (en) |
GB (1) | GB2427360A (en) |
MX (1) | MX2007016547A (en) |
PL (1) | PL1909845T3 (en) |
SI (1) | SI1909845T1 (en) |
WO (1) | WO2006136586A2 (en) |
Cited By (77)
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WO2008081418A1 (en) * | 2007-01-05 | 2008-07-10 | Covx Technologies Ireland Limited | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
WO2008148839A2 (en) * | 2007-06-08 | 2008-12-11 | Ascendis Pharma As | Long-acting polymeric prodrugs of exendin |
EP2067494A1 (en) | 2007-12-04 | 2009-06-10 | Charité-Universitätsmedizin Berlin | Sheet or tubular structure consisting of elastic biocompatible material and its use |
WO2009095479A3 (en) * | 2008-02-01 | 2009-10-01 | Ascendis Pharma As | Prodrug comprising a self-cleavable linker |
EP2113256A1 (en) | 2008-04-29 | 2009-11-04 | Ascendis Pharma AS | PEGylated rhGH compounds |
WO2010100220A1 (en) | 2009-03-05 | 2010-09-10 | Ascendis Pharma As | Interferon alpha carrier prodrugs |
WO2011005540A1 (en) | 2009-06-22 | 2011-01-13 | Burnham Institute For Medical Research | Methods and compositions using peptides and proteins with c-terminal elements |
WO2011012722A1 (en) | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Prodrugs containing an aromatic amine connected by an amido bond to a linker |
WO2011012715A1 (en) | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Biodegradable polyethylene glycol based water-insoluble hydrogels |
WO2011012719A1 (en) * | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Long acting insulin composition |
WO2011057027A2 (en) | 2009-11-04 | 2011-05-12 | Janssen Pharmaceutica Nv | Method for treating heart failure with stresscopin-like peptides |
WO2011073234A2 (en) | 2009-12-15 | 2011-06-23 | Ascendis Pharma As | Growth hormone composition |
AU2011254001B2 (en) * | 2007-01-05 | 2012-08-02 | Covx Technologies Ireland Limited | Glucagon-like protein-1 receptor (GLP-1R) agonist compounds |
WO2012118778A1 (en) | 2011-02-28 | 2012-09-07 | Sanford-Burnham Medical Research Institute | Truncated car peptides and methods and compositions using truncated car peptides |
WO2012166585A2 (en) | 2011-05-31 | 2012-12-06 | Airware, Inc. | Re-calibration of ab ndir gas sensors |
WO2013024048A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Polymeric hyperbranched carrier-linked prodrugs |
WO2013024047A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | High-loading water-soluble carrier-linked prodrugs |
WO2013024053A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Carrier-linked prodrugs having reversible carboxylic ester linkages |
WO2013024049A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Protein carrier-linked prodrugs |
WO2013053856A1 (en) | 2011-10-12 | 2013-04-18 | Ascendis Pharma A/S | Prevention and treatment of ocular conditions |
WO2013064508A1 (en) | 2011-11-03 | 2013-05-10 | Bayer Pharma Aktiengesellschaft | Polyethylene glycol based prodrug of adrenomedullin and use thereof |
WO2013064455A1 (en) | 2011-11-03 | 2013-05-10 | Bayer Intellectual Property Gmbh | Tyrosine based linkers for the releasable connection of peptides |
WO2014056923A1 (en) | 2012-10-11 | 2014-04-17 | Ascendis Pharma Ophthalmology Division A/S | Vegf neutralizing prodrugs for the treatment of ocular conditions |
WO2014056926A1 (en) | 2012-10-11 | 2014-04-17 | Ascendis Pharma A/S | Hydrogel prodrugs |
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US9133276B2 (en) | 2010-09-17 | 2015-09-15 | Sanofi-Aventis Deutschland Gmbh | Prodrugs comprising an exendin linker conjugate |
US9138462B2 (en) | 2009-07-31 | 2015-09-22 | Sanofi-Aventis Deutschland Gmbh | Prodrugs comprising an insulin linker conjugate |
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WO2016196124A2 (en) | 2015-05-29 | 2016-12-08 | Ascendis Pharma Inc. | Prodrugs comprising a pyroglutamate linker |
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WO2017161174A1 (en) | 2016-03-16 | 2017-09-21 | Prolynx Llc | Extended release conjugates of exenatide analogs |
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Citations (7)
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CN101242859B (en) | 2013-04-03 |
US8980242B2 (en) | 2015-03-17 |
GB0512705D0 (en) | 2005-07-27 |
CA2613208C (en) | 2014-01-21 |
PL1909845T3 (en) | 2013-01-31 |
WO2006136586A3 (en) | 2007-07-26 |
GB2427360A (en) | 2006-12-27 |
CY1113204T1 (en) | 2016-04-13 |
MX2007016547A (en) | 2008-02-21 |
BRPI0612536A2 (en) | 2010-11-23 |
EP1909845B1 (en) | 2012-08-15 |
JP2008543916A (en) | 2008-12-04 |
ES2390816T3 (en) | 2012-11-16 |
AU2006260914B2 (en) | 2011-04-14 |
JP5121068B2 (en) | 2013-01-16 |
US20100291021A1 (en) | 2010-11-18 |
SI1909845T1 (en) | 2012-11-30 |
CN101242859A (en) | 2008-08-13 |
EP1909845A2 (en) | 2008-04-16 |
CA2613208A1 (en) | 2006-12-28 |
AU2006260914A1 (en) | 2006-12-28 |
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