WO2006133256A2 - Method for restoration of nutrient flow to nucleus pulposa - Google Patents

Method for restoration of nutrient flow to nucleus pulposa Download PDF

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Publication number
WO2006133256A2
WO2006133256A2 PCT/US2006/022053 US2006022053W WO2006133256A2 WO 2006133256 A2 WO2006133256 A2 WO 2006133256A2 US 2006022053 W US2006022053 W US 2006022053W WO 2006133256 A2 WO2006133256 A2 WO 2006133256A2
Authority
WO
WIPO (PCT)
Prior art keywords
nucleus pulposa
pulposa
end plate
nucleus
implant
Prior art date
Application number
PCT/US2006/022053
Other languages
French (fr)
Other versions
WO2006133256A9 (en
WO2006133256A3 (en
Inventor
David G. Matsuura
Walter Dean Gillespie
Philip J. Simpson
Original Assignee
Flex Partners, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flex Partners, Inc. filed Critical Flex Partners, Inc.
Priority to EP06772385.8A priority Critical patent/EP1887988B1/en
Priority to JP2008515854A priority patent/JP4759051B2/en
Priority to US11/916,641 priority patent/US8740979B2/en
Publication of WO2006133256A2 publication Critical patent/WO2006133256A2/en
Publication of WO2006133256A9 publication Critical patent/WO2006133256A9/en
Publication of WO2006133256A3 publication Critical patent/WO2006133256A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7061—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant for stabilising vertebrae or discs by improving the condition of their tissues, e.g. using implanted medication or fluid exchange
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus

Definitions

  • the present invention relates to methods and apparatus for restoration of nutrition to the nucleus pulposa or other avascular body tissues such as joint cartilage, by placement of a device or material that promotes nutrient flow into disc tissue from the vertebral body, other skeletal structures, or surrounding tissue.
  • the subchondral bone cartilaginous endplate becomes impermeable to nutrient transfer to, and removal of waste metabolites from the nucleus pulposa.
  • the increasingly oxygen and glucose starved cellular matrix of the nucleus pulposa decreases in pH until its normal physiological processes are interrupted.
  • the osmotic gradient into the disc is reduced which leads to decreasing water content in the nucleus pulposa.
  • a dehydrated nucleus pulposa places more stress upon the surrounding annular tissue, leading to fissures and herniation.
  • the degenerated disc may cause significant discomfort or disability so that major surgical intervention such as total disc replacement or spinal fusion is required.
  • Methods and devices are disclosed that provide a technique for restoration of nutrient transfer from the vertebral body and surrounding tissues, via the vertebral body endplate, to the nucleus pulposa.
  • Successful restoration of nutrient transfer to the nucleus pulposa would interrupt the progression of disc degeneration and restore normal function to the disc.
  • AU three methods summarized here for treatment of the diseased disc would employ minimally invasive surgical techniques for creating an access portal in the vertebral body adjacent to the diseased disc. No disruption of the annulus would be required for these procedures.
  • a portion of the endplate would then be removed and a device which facilitates transport of nutrients from the vertebral body cancellous bone would be inserted in the cavity.
  • the distal end of the device would be placed in contact with the nucleus pulposa. Any portion of the cavity that the device does not occupy will be back filled to prevent undesired motion of the device.
  • all or nearly all of the subchondral bone-cartilaginous endplate would be removed and replaced with a device which facilitates transport of nutrients from the vertebral body cancellous bone to the nucleus pulposa such as a sintered porous stainless steel puck or osmotic membrane. Cancellous bone material removed to gain access to the endplate would be backfilled to prevent un-desired motion of the device
  • the endplate would be ported with a multiplicity of small holes. The cavity in the vertebral body created to access the endplate would be filled with a material that would facilitate transport of nutrients from the vertebral body and surrounding tissues.
  • the present invention provides methods and devices for establishing a nutrient flow channel between a first side and a second side of a boney barrier.
  • the boney barrier is a vertebral body end plate.
  • a passageway is formed through the bone barrier, to permit the transport of nutrients therethrough.
  • a device may be installed within the passageway, such that a first end of the device is in communication with a target tissue such as nucleus pulposa, and a second end of the device is in communication with a nutrient source.
  • the nutrient source may be the cancellous bone of an adjacent vertebral body, a natural source of nutrients outside of the vertebral body, or an implanted source of nutrients.
  • the device includes at least one flow path between the first and second ends, to facilitate the transport of nutrient therethrough.
  • Figure 1 illustrates the three proposed pathways for restoring nutrient flow to the annulus pulposa.
  • Figure 2 illustrates, with multiple views, features of the first described device for nutrient transfer.
  • Figure 3 illustrates, in section view, functional and anatomical aspects of the first described method and device as it relates to the surrounding anatomy after placement.
  • Figure 4 illustrates, in section view, functional and anatomical aspects of the second described method and device as it relates to the surrounding anatomy after placement.
  • Figure 5 illustrates, with multiple views, the features of the device disclosed in the second described method.
  • Figure 6 illustrates, in section view, functional and anatomical aspects of the third described method and device as it relates to the surrounding anatomy after placement.
  • Figure 7 is an image of the lateral aspect of two different prototype implant devices.
  • Figure 8 is an image showing the hexagonal sockets which allow the implants to be screwed into the vertebral body.
  • Figure 9 is an image showing the cavity inside the implants which will be filled with a material that promotes nutrient transfer to the nucleus pulposa.
  • FIG. 1 A first route from the cancellous bone material 4 which occupies the center of the vertebral body, to the nucleus pulposa 2 , a second route from the tissues surrounding the vertebral body 8, via the vertebral body endplate 5 to the nucleus pulposa 2, and a third route from both regions simultaneously.
  • a device is shown that is generally cylindrical in shape having a coarse threaded exterior 1, with periodic interruptions in the thread 2 which allow for stabilization of the device as post placement bony ingrowth occurs.
  • the device will have a core 4 composed of some material such as porous sintered stainless steel, which facilitates the transfer of nutrients from its proximal end 6 to its distal end 5. Additionally, a multiplicity of transverse passages 3 from the exterior surface of the device, to its inner porous core are present to facilitate nutrient transfer.
  • the proximal end 6 of the device will have a feature 7 which accommodates tools utilized for its placement.
  • the device is shown post placement such that its distal end 8 is in contact with the nucleus pulposa 2.
  • Cortical and cancellous bone material removed to place the device has been replace by a substance 6 which will prevent the device from undesired movement after placement.
  • Nutrient transfer will occur from the cancellous bone 9 via the back fill material 6 through the core of the device 1 to the nucleus pulposa 2.
  • nutrient transfer will occur from the cancellous bone 9 through passageways 3 along the sides of the device, via the core of the device 1 to the nucleus pulposa 2.
  • a second device 2 which replaces much of the vertebral body endplate that contacts the nucleus pulposa 3.
  • the cancellous 4 and cortical bone removed to facilitate placement of the device will be replaced with a substance 1, which will serve to both stabilize the device after its placement, and facilitate transport of nutrients to the device from the surrounding cancellous bone 4.
  • the device will allow flow of nutrient material into the nucleus pulposa 3.
  • FIG. 5 several views are presented of the device shown implanted in Figure 4.
  • the device has a face 1 that is intended to directly contact the nucleus pulposa, a feature 2 that facilitates appropriate placement in the area where the end plate was removed from the vertebral body, and a second face 3 that will contact back-fill material used to replace the cancellous bone removed from the vertebral body during the placement procedure.
  • FIG. 6 a third method is illustrated for restoration of nutrient flow to the nucleus pulposa 4.
  • a cavity 5 is created to allow a multiplicity of access ports 2 to be drilled to the nucleus pulposa 4.
  • the cavity 5 and the access ports 2 are then filled with a material that facilitates nutrient transfer from the cancellous bone 3 and the tissues surrounding the vertebral body.
  • two devices are shown that are generally cylindrical in shape having a coarse threaded exterior 1, with periodic interruptions in the thread 2 which allow for stabilization of the device as post placement bony ingrowth occurs. Additionally, a multiplicity of transverse passages 3 from the exterior surface of the device, to its inner porous core are present to facilitate nutrient transfer.
  • FIG. 9 two devices are shown which have a cavity 4, which will be filled with a material such as sintered stainless steel, that promotes the transfer of nutrients to the nucleus pulposa.

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  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Prostheses (AREA)

Abstract

Disclosed are methods and devices for restoring or establishing nutrient flow to the nucleus pulposa. An implant comprises a nutrient flow path for extending between a source of nutrients and the nucleus pulposa. The implant is positioned within the patient such that a first end is in nutrient flow communication with a subject nucleus pulposa, and the source end is positioned in nutrient flow communication with a source of nutrients.

Description

SYSTEM AND METHOD FOR RESTORATION OF NUTRIENT FLOW
TO NUCLEUS PULPOSA
BACKGROUND OF THE INVENTION Field of the Invention
[0001] The present invention relates to methods and apparatus for restoration of nutrition to the nucleus pulposa or other avascular body tissues such as joint cartilage, by placement of a device or material that promotes nutrient flow into disc tissue from the vertebral body, other skeletal structures, or surrounding tissue.
SUMMARY OF THE INVENTION
[0002] As a result of the certain disease states, the subchondral bone cartilaginous endplate becomes impermeable to nutrient transfer to, and removal of waste metabolites from the nucleus pulposa. The increasingly oxygen and glucose starved cellular matrix of the nucleus pulposa decreases in pH until its normal physiological processes are interrupted. As a result, the osmotic gradient into the disc is reduced which leads to decreasing water content in the nucleus pulposa. A dehydrated nucleus pulposa places more stress upon the surrounding annular tissue, leading to fissures and herniation. Eventually, the degenerated disc may cause significant discomfort or disability so that major surgical intervention such as total disc replacement or spinal fusion is required.
[0003] Methods and devices are disclosed that provide a technique for restoration of nutrient transfer from the vertebral body and surrounding tissues, via the vertebral body endplate, to the nucleus pulposa. Successful restoration of nutrient transfer to the nucleus pulposa would interrupt the progression of disc degeneration and restore normal function to the disc. AU three methods summarized here for treatment of the diseased disc would employ minimally invasive surgical techniques for creating an access portal in the vertebral body adjacent to the diseased disc. No disruption of the annulus would be required for these procedures. For the first method, a portion of the endplate would then be removed and a device which facilitates transport of nutrients from the vertebral body cancellous bone would be inserted in the cavity. The distal end of the device would be placed in contact with the nucleus pulposa. Any portion of the cavity that the device does not occupy will be back filled to prevent undesired motion of the device. For the second method, all or nearly all of the subchondral bone-cartilaginous endplate would be removed and replaced with a device which facilitates transport of nutrients from the vertebral body cancellous bone to the nucleus pulposa such as a sintered porous stainless steel puck or osmotic membrane. Cancellous bone material removed to gain access to the endplate would be backfilled to prevent un-desired motion of the device For the third method the endplate would be ported with a multiplicity of small holes. The cavity in the vertebral body created to access the endplate would be filled with a material that would facilitate transport of nutrients from the vertebral body and surrounding tissues.
[0004] Thus, the present invention provides methods and devices for establishing a nutrient flow channel between a first side and a second side of a boney barrier. In the disclosed implementations of the invention, the boney barrier is a vertebral body end plate. In accordance with the method of the present invention, a passageway is formed through the bone barrier, to permit the transport of nutrients therethrough. A device may be installed within the passageway, such that a first end of the device is in communication with a target tissue such as nucleus pulposa, and a second end of the device is in communication with a nutrient source. The nutrient source may be the cancellous bone of an adjacent vertebral body, a natural source of nutrients outside of the vertebral body, or an implanted source of nutrients. The device includes at least one flow path between the first and second ends, to facilitate the transport of nutrient therethrough.
BRIEF DESCRIPTION OF THE DRAWINGS [0005] Figure 1 illustrates the three proposed pathways for restoring nutrient flow to the annulus pulposa.
[0006] Figure 2 illustrates, with multiple views, features of the first described device for nutrient transfer. [0007] Figure 3 illustrates, in section view, functional and anatomical aspects of the first described method and device as it relates to the surrounding anatomy after placement.
[0008] Figure 4 illustrates, in section view, functional and anatomical aspects of the second described method and device as it relates to the surrounding anatomy after placement.
[0009] Figure 5 illustrates, with multiple views, the features of the device disclosed in the second described method.
[0010] Figure 6 illustrates, in section view, functional and anatomical aspects of the third described method and device as it relates to the surrounding anatomy after placement.
[0011] Figure 7 is an image of the lateral aspect of two different prototype implant devices.
[0012] Figure 8 is an image showing the hexagonal sockets which allow the implants to be screwed into the vertebral body.
[0013] Figure 9 is an image showing the cavity inside the implants which will be filled with a material that promotes nutrient transfer to the nucleus pulposa.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT [0014] Referring to Figure 1, three potential pathways for nutrient transfer to the nucleus pulposa 2 are illustrated: A first route from the cancellous bone material 4 which occupies the center of the vertebral body, to the nucleus pulposa 2 , a second route from the tissues surrounding the vertebral body 8, via the vertebral body endplate 5 to the nucleus pulposa 2, and a third route from both regions simultaneously.
[0015] Referring to Figure 2, a device is shown that is generally cylindrical in shape having a coarse threaded exterior 1, with periodic interruptions in the thread 2 which allow for stabilization of the device as post placement bony ingrowth occurs. The device will have a core 4 composed of some material such as porous sintered stainless steel, which facilitates the transfer of nutrients from its proximal end 6 to its distal end 5. Additionally, a multiplicity of transverse passages 3 from the exterior surface of the device, to its inner porous core are present to facilitate nutrient transfer. Furthermore, the proximal end 6 of the device will have a feature 7 which accommodates tools utilized for its placement.
[0016] Referring to Figure 3, the device is shown post placement such that its distal end 8 is in contact with the nucleus pulposa 2. Cortical and cancellous bone material removed to place the device has been replace by a substance 6 which will prevent the device from undesired movement after placement. Nutrient transfer will occur from the cancellous bone 9 via the back fill material 6 through the core of the device 1 to the nucleus pulposa 2. Additionally, nutrient transfer will occur from the cancellous bone 9 through passageways 3 along the sides of the device, via the core of the device 1 to the nucleus pulposa 2.
[0017] Referring to Figure 4, a second device 2 is shown which replaces much of the vertebral body endplate that contacts the nucleus pulposa 3. The cancellous 4 and cortical bone removed to facilitate placement of the device will be replaced with a substance 1, which will serve to both stabilize the device after its placement, and facilitate transport of nutrients to the device from the surrounding cancellous bone 4. The device will allow flow of nutrient material into the nucleus pulposa 3.
[0018] Referring to Figure 5, several views are presented of the device shown implanted in Figure 4. The device has a face 1 that is intended to directly contact the nucleus pulposa, a feature 2 that facilitates appropriate placement in the area where the end plate was removed from the vertebral body, and a second face 3 that will contact back-fill material used to replace the cancellous bone removed from the vertebral body during the placement procedure.
[0019] Referring to Figure 6, a third method is illustrated for restoration of nutrient flow to the nucleus pulposa 4. A cavity 5 is created to allow a multiplicity of access ports 2 to be drilled to the nucleus pulposa 4. The cavity 5 and the access ports 2 are then filled with a material that facilitates nutrient transfer from the cancellous bone 3 and the tissues surrounding the vertebral body.
[0020] Referring to Figure 7, two devices are shown that are generally cylindrical in shape having a coarse threaded exterior 1, with periodic interruptions in the thread 2 which allow for stabilization of the device as post placement bony ingrowth occurs. Additionally, a multiplicity of transverse passages 3 from the exterior surface of the device, to its inner porous core are present to facilitate nutrient transfer.
[0021] Referring to Figure 8, two devices are shown which have a feature 7 which accommodates tools utilized for its placement.
[0022] Referring to Figure 9, two devices are shown which have a cavity 4, which will be filled with a material such as sintered stainless steel, that promotes the transfer of nutrients to the nucleus pulposa.
[0023] In summary, three separate methods and devices are disclosed to restore nutrient flow to the nucleus pulposa. Each of the three described techniques offers the potential to restore normal physiology to the intervertebral disc. Restoration of normal function would eliminate the need for more traumatic surgical techniques such as total disc replacement or spinal fusion. Additionally, these devices and techniques could be used to restore nutrient flow to other avascular tissues such as joint cartilage.

Claims

WHAT IS CLAIMED IS:
1. A method for restoring or establishing nutrient flow to the nucleus pulposa in a spine, comprising the steps of: identifying a nucleus pulposa in a patient, the nucleus pulposa surrounded by an upper end plate, a lower end plate and an annulus; providing a flow path through at least one of the upper end plate and lower end plate to place the nucleus pulposa in flow communication with adjacent tissue; and implanting a device in the opening, to maintain a flow path through the end plate to enable nutrient flow to the nucleus pulposa.
2. A method as in Claim 1, wherein the flow path extends from the nucleus pulposa into cancellous bone of an adjacent vertebral body.
3. A method as in Claim 1, wherein the flow path extends from the nucleus pulposa to tissue outside of the spine.
4. An implant, for maintaining nutrient flow to the nucleus pulposa in a spine, comprising: a fluid flow enabling structure, dimensioned and adapted to extend through a boney end plate on a vertebral body such that a first end of the implant is in communication with the nucleus pulposa on a first side of the end plate; and a second end adapted and dimensioned to be placed in fluid communication with tissue on a second side of the end plate.
5. An implant as in Claim 4, wherein the implant comprises a tubular body having a fluid flow path extending therethrough.
6. An implant as in Claim 5, further comprising a thread on an exterior surface of the tubular body.
7. An implant as in Claim 5, further comprising a plurality of apertures through a side wall of the tubular body.
PCT/US2006/022053 2005-06-07 2006-06-07 Method for restoration of nutrient flow to nucleus pulposa WO2006133256A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06772385.8A EP1887988B1 (en) 2005-06-07 2006-06-07 System for restoration of nutrient flow to nucleus pulposa
JP2008515854A JP4759051B2 (en) 2005-06-07 2006-06-07 System and method for restoring nutrient flow to the nucleus pulposus
US11/916,641 US8740979B2 (en) 2005-06-07 2006-06-07 System and method for restoration of nutrient flow to nucleus pulposa

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68829905P 2005-06-07 2005-06-07
US60/688,299 2005-06-07

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WO2006133256A2 true WO2006133256A2 (en) 2006-12-14
WO2006133256A9 WO2006133256A9 (en) 2007-02-22
WO2006133256A3 WO2006133256A3 (en) 2007-05-24

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US (1) US8740979B2 (en)
EP (1) EP1887988B1 (en)
JP (1) JP4759051B2 (en)
WO (1) WO2006133256A2 (en)

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US8709054B2 (en) 2007-08-07 2014-04-29 Transcorp, Inc. Implantable vertebral frame systems and related methods for spinal repair
US8430882B2 (en) 2007-09-13 2013-04-30 Transcorp, Inc. Transcorporeal spinal decompression and repair systems and related methods
US9913726B2 (en) * 2010-02-24 2018-03-13 Globus Medical, Inc. Expandable intervertebral spacer and method of posterior insertion thereof
US9089438B2 (en) 2011-06-28 2015-07-28 Spinal Elements, Inc. Apparatus for promoting movement of nutrients to intervertebral space and method of use

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Also Published As

Publication number Publication date
JP4759051B2 (en) 2011-08-31
WO2006133256A9 (en) 2007-02-22
EP1887988B1 (en) 2015-08-19
WO2006133256A3 (en) 2007-05-24
US20080215152A1 (en) 2008-09-04
EP1887988A4 (en) 2013-03-06
EP1887988A2 (en) 2008-02-20
JP2008541993A (en) 2008-11-27
US8740979B2 (en) 2014-06-03

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