WO2006133128A3 - INHIBITION OF EPAC, PHOSPHOLIPASE Cϵ, AND PHOSPHOLIPASE D TO TREAT PAIN - Google Patents

INHIBITION OF EPAC, PHOSPHOLIPASE Cϵ, AND PHOSPHOLIPASE D TO TREAT PAIN Download PDF

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Publication number
WO2006133128A3
WO2006133128A3 PCT/US2006/021807 US2006021807W WO2006133128A3 WO 2006133128 A3 WO2006133128 A3 WO 2006133128A3 US 2006021807 W US2006021807 W US 2006021807W WO 2006133128 A3 WO2006133128 A3 WO 2006133128A3
Authority
WO
WIPO (PCT)
Prior art keywords
epac
epsiv
phospholipase
plc
pld
Prior art date
Application number
PCT/US2006/021807
Other languages
French (fr)
Other versions
WO2006133128A2 (en
Inventor
Jon D Levine
Robert O Messing
Original Assignee
Univ California
Jon D Levine
Robert O Messing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Jon D Levine, Robert O Messing filed Critical Univ California
Priority to EP06772207A priority Critical patent/EP1896039A2/en
Publication of WO2006133128A2 publication Critical patent/WO2006133128A2/en
Publication of WO2006133128A3 publication Critical patent/WO2006133128A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2842—Pain, e.g. neuropathic pain, psychogenic pain

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides methods, compositions, and kits useful for reducing pain in a subject by inhibiting Epac, PLCϵ, and/or PLD. In addition, the invention provides a variety of prescreening and screening methods aimed at identifying agents that reduce pain. Methods of the invention can involve assaying test agent binding to Epac, PLCϵ, or PLD. Alternatively, test agents can be screened for their ability to alter the level of Epac, PLCϵ, or PLD polypeptides, polynucleotides, or action.
PCT/US2006/021807 2005-06-07 2006-06-05 INHIBITION OF EPAC, PHOSPHOLIPASE Cϵ, AND PHOSPHOLIPASE D TO TREAT PAIN WO2006133128A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06772207A EP1896039A2 (en) 2005-06-07 2006-06-05 Inhibition of epac, phospholipase c ''epsilon'', and phospholipase d to treat pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68854605P 2005-06-07 2005-06-07
US60/688,546 2005-06-07

Publications (2)

Publication Number Publication Date
WO2006133128A2 WO2006133128A2 (en) 2006-12-14
WO2006133128A3 true WO2006133128A3 (en) 2008-08-07

Family

ID=37499022

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/021807 WO2006133128A2 (en) 2005-06-07 2006-06-05 INHIBITION OF EPAC, PHOSPHOLIPASE Cϵ, AND PHOSPHOLIPASE D TO TREAT PAIN

Country Status (4)

Country Link
US (1) US20070060548A1 (en)
EP (1) EP1896039A2 (en)
CN (1) CN101378656A (en)
WO (1) WO2006133128A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007006544A2 (en) * 2005-07-12 2007-01-18 Vrije Universiteit Brussel Cyclic adenosine monophosphate compounds for the treatment of immune-related disorders
WO2011014622A1 (en) * 2009-07-31 2011-02-03 The Trustees Of Columbia University In The City Of New York Modulation of phospholipase d for the treatment of the acute and chronic effects of ethanol
KR101213070B1 (en) 2010-11-09 2012-12-18 부산대학교 산학협력단 Composition for Prevention or Treatment of Rheumatoid Arthritis Comprising the Phospholipase D1 inhibitor
CA2837871C (en) 2011-06-01 2021-12-07 Anthrogenesis Corporation Treatment of pain using placental stem cells
WO2014053315A1 (en) * 2012-10-02 2014-04-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Tetrahydroquinoline derivatives and their use as epac inhibitors
WO2014123680A1 (en) * 2013-02-08 2014-08-14 The Board Of Regents Of The University Of Texas System Antimicrobial methods using inhibitors of exchange proteins directly activated by camp (epac)
US9737512B2 (en) * 2015-03-11 2017-08-22 The Board Of Regents Of The University Of Texas System Methods and compositions for treating chronic pain
CN117503766B (en) * 2024-01-04 2024-04-26 中国康复研究中心 Application of PLD inhibitor in preparation of medicine for treating spinal cord injury

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519163A (en) * 1993-10-15 1996-05-21 Merck & Co., Inc. Inhibitors of phosphoinositide-specific phospholipase C
WO2003104250A1 (en) * 2002-06-07 2003-12-18 Kylix, B. V. New compounds for modulating the activity of exchange proteins directly activated by camp (epacs)
US20040002526A1 (en) * 2002-04-03 2004-01-01 Cell Therapeutics, Inc. Phospholipase D inhibitors and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519163A (en) * 1993-10-15 1996-05-21 Merck & Co., Inc. Inhibitors of phosphoinositide-specific phospholipase C
US20040002526A1 (en) * 2002-04-03 2004-01-01 Cell Therapeutics, Inc. Phospholipase D inhibitors and uses thereof
WO2003104250A1 (en) * 2002-06-07 2003-12-18 Kylix, B. V. New compounds for modulating the activity of exchange proteins directly activated by camp (epacs)

Also Published As

Publication number Publication date
CN101378656A (en) 2009-03-04
US20070060548A1 (en) 2007-03-15
WO2006133128A2 (en) 2006-12-14
EP1896039A2 (en) 2008-03-12

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