WO2006130669A3 - Anchor-assisted fragment selection and directed assembly - Google Patents

Anchor-assisted fragment selection and directed assembly Download PDF

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Publication number
WO2006130669A3
WO2006130669A3 PCT/US2006/021088 US2006021088W WO2006130669A3 WO 2006130669 A3 WO2006130669 A3 WO 2006130669A3 US 2006021088 W US2006021088 W US 2006021088W WO 2006130669 A3 WO2006130669 A3 WO 2006130669A3
Authority
WO
WIPO (PCT)
Prior art keywords
anchor
assisted
compounds
provides
directed assembly
Prior art date
Application number
PCT/US2006/021088
Other languages
French (fr)
Other versions
WO2006130669A2 (en
Inventor
Andrew M Stern
Scott L Harbeson
Edward M Driggers
Kerry L Spear
Original Assignee
Ensemble Discovery Corp
Andrew M Stern
Scott L Harbeson
Edward M Driggers
Kerry L Spear
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ensemble Discovery Corp, Andrew M Stern, Scott L Harbeson, Edward M Driggers, Kerry L Spear filed Critical Ensemble Discovery Corp
Priority to US11/915,533 priority Critical patent/US20090163371A1/en
Priority to EP06784513A priority patent/EP1891242A2/en
Publication of WO2006130669A2 publication Critical patent/WO2006130669A2/en
Publication of WO2006130669A3 publication Critical patent/WO2006130669A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens

Abstract

The invention provides methods for compound and lead generation and discovery. In particular, the present invention provides a method for generating compounds and for selecting compounds that bind to a target. The present invention provides a way by which anchors (e.g., weak binders) and anchor-scaffold conjugates can be evolved into new generations of compounds having improved target binding and other desired pharmaceutical properties through control of both synthetic input and selection criteria.
PCT/US2006/021088 2005-05-31 2006-05-31 Anchor-assisted fragment selection and directed assembly WO2006130669A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/915,533 US20090163371A1 (en) 2005-05-31 2006-05-31 Anchor-Assisted Fragment Selection and Directed Assembly
EP06784513A EP1891242A2 (en) 2005-05-31 2006-05-31 Anchor-assisted fragment selection and directed assembly

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US68600005P 2005-05-31 2005-05-31
US60/686,000 2005-05-31
US71149705P 2005-08-26 2005-08-26
US60/711,497 2005-08-26
US80049606P 2006-05-15 2006-05-15
US60/800,496 2006-05-15

Publications (2)

Publication Number Publication Date
WO2006130669A2 WO2006130669A2 (en) 2006-12-07
WO2006130669A3 true WO2006130669A3 (en) 2007-08-02

Family

ID=37482255

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/021088 WO2006130669A2 (en) 2005-05-31 2006-05-31 Anchor-assisted fragment selection and directed assembly

Country Status (3)

Country Link
US (1) US20090163371A1 (en)
EP (1) EP1891242A2 (en)
WO (1) WO2006130669A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US9109248B2 (en) 2002-10-30 2015-08-18 Nuevolution A/S Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
EP1670939B1 (en) 2003-09-18 2009-11-04 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
EP1885892A2 (en) * 2005-05-03 2008-02-13 Ensemble Discovery Corporation Turnover probes and use thereof for nucleic acid detection
DE602006013134D1 (en) * 2005-06-17 2010-05-06 Harvard College ITERATED ADDRESSING REACTION TRANSACTIONS OF NUCLEIC ACID-MEDIATED CHEMISTRY
US8338565B2 (en) * 2008-08-20 2012-12-25 Ensemble Therapeutics Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha
ES2713873T3 (en) 2010-04-16 2019-05-24 Nuevolution As Bifunctional complexes and methods for making and using such complexes
US9637773B2 (en) 2011-01-13 2017-05-02 Enzo Life Sciences, Inc. Compounds and methods for detection of enzymes that remove formyl, succinyl, methyl succinyl or myristoyl groups from ε-amino lysine moieties
MX2016007826A (en) 2013-12-16 2017-03-31 Genentech Inc Peptidomimetic compounds and antibody-drug conjugates thereof.
CZ2014527A3 (en) * 2014-08-05 2016-02-17 Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. Detection method of analyte active forms in a sample and determination of ability of other substance to bind in active spots of such analytes
US20180340174A1 (en) 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
WO2016205176A1 (en) 2015-06-15 2016-12-22 Genentech, Inc. Antibodies and immunoconjugates

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WO2003031591A2 (en) * 2001-10-10 2003-04-17 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
US20040049008A1 (en) * 2001-06-20 2004-03-11 Nuevolution A/S Templated molecules and methods for using such molecules
US20040180412A1 (en) * 2002-08-19 2004-09-16 The President And Fellows Of Harvard College Evolving new molecular function
US20050003360A1 (en) * 2001-11-13 2005-01-06 Ruo-Pang Huang Array systems and methods
WO2005026387A1 (en) * 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds

Patent Citations (5)

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US20040049008A1 (en) * 2001-06-20 2004-03-11 Nuevolution A/S Templated molecules and methods for using such molecules
WO2003031591A2 (en) * 2001-10-10 2003-04-17 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
US20050003360A1 (en) * 2001-11-13 2005-01-06 Ruo-Pang Huang Array systems and methods
US20040180412A1 (en) * 2002-08-19 2004-09-16 The President And Fellows Of Harvard College Evolving new molecular function
WO2005026387A1 (en) * 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds

Non-Patent Citations (5)

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DE FIGUEIREDO PAUL ET AL: "DARTs: A DNA-based in vitro polypeptide display technology", PROTEOMICS, WILEY - VCH VERLAG, WEINHEIM, DE, vol. 4, no. 10, October 2004 (2004-10-01), pages 3128 - 3140, XP002330884, ISSN: 1615-9853 *
DOYON J B ET AL: "HIGHLY SENSITIVE IN VITRO SELECTIONS FOR DNA-LINKED SYNTHETIC SMALL MOLECULES WITH PROTEIN BINDING AFFINTIY AND SPECIFICITY", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 125, no. 41, 5 October 2003 (2003-10-05), pages 12372 - 12373, XP001172427, ISSN: 0002-7863 *
GARTNER Z J ET AL: "DNA-templated organic synthesis and selection of a library of macrocycles", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 305, no. 5690, 10 September 2004 (2004-09-10), pages 1601 - 1605, XP002397753, ISSN: 0036-8075 *
HALPIN DAVID R ET AL: "DNA display II. Genetic manipulation of combinatorial chemistry libraries for small-molecule evolution", PLOS BIOLOGY, vol. 2, no. 7, July 2004 (2004-07-01), pages 1022 - 1030, XP002424416 *
REES DAVID C ET AL: "FRAGMENT-BASED LEAD DISCOVERY", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, BASINGSTOKE, GB, vol. 3, no. 8, August 2004 (2004-08-01), pages 660 - 672, XP009072515, ISSN: 1474-1784 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US9109248B2 (en) 2002-10-30 2015-08-18 Nuevolution A/S Method for the synthesis of a bifunctional complex
US9284600B2 (en) 2002-10-30 2016-03-15 Neuvolution A/S Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries

Also Published As

Publication number Publication date
US20090163371A1 (en) 2009-06-25
EP1891242A2 (en) 2008-02-27
WO2006130669A2 (en) 2006-12-07

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