WO2006130190A3 - Proline suppresses apoptosis - Google Patents

Proline suppresses apoptosis Download PDF

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Publication number
WO2006130190A3
WO2006130190A3 PCT/US2006/004349 US2006004349W WO2006130190A3 WO 2006130190 A3 WO2006130190 A3 WO 2006130190A3 US 2006004349 W US2006004349 W US 2006004349W WO 2006130190 A3 WO2006130190 A3 WO 2006130190A3
Authority
WO
WIPO (PCT)
Prior art keywords
proline
compositions
plants
compared
described
Prior art date
Application number
PCT/US2006/004349
Other languages
French (fr)
Other versions
WO2006130190A2 (en
Inventor
Martin B Dickman
Original Assignee
Martin B Dickman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US65157105P priority Critical
Priority to US60/651,571 priority
Application filed by Martin B Dickman filed Critical Martin B Dickman
Publication of WO2006130190A2 publication Critical patent/WO2006130190A2/en
Publication of WO2006130190A3 publication Critical patent/WO2006130190A3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401Proline; Derivatives thereof, e.g. captopril

Abstract

The discovery that proline is a potent antioxidant and inhibitor of programmed cell death is described, as are proline-containing compositions and methods for using such compositions in response to, or in advance of, experiencing oxidative stress. These compositions and methods find application across the animal and plant kingdoms. Transgenic plants exhibiting altered intracellular proline levels, as compared to plants lacking such an alteration, are also described, as are transgenic plants that exhibit altered expression of one or more genes involved in the metabolism of reactive oxygen species (ROS), as compared to unmodified plants.
PCT/US2006/004349 2005-02-07 2006-02-07 Proline suppresses apoptosis WO2006130190A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US65157105P true 2005-02-07 2005-02-07
US60/651,571 2005-02-07

Publications (2)

Publication Number Publication Date
WO2006130190A2 WO2006130190A2 (en) 2006-12-07
WO2006130190A3 true WO2006130190A3 (en) 2007-01-25

Family

ID=37482104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/004349 WO2006130190A2 (en) 2005-02-07 2006-02-07 Proline suppresses apoptosis

Country Status (1)

Country Link
WO (1) WO2006130190A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170348266A1 (en) * 2014-11-13 2017-12-07 Buck Institute For Research On Aging Inhibition of proline catabolism for the treatment of cancer and other therapeutic applications

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins

Also Published As

Publication number Publication date
WO2006130190A2 (en) 2006-12-07

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