WO2006130190A3 - Proline suppresses apoptosis - Google Patents

Proline suppresses apoptosis Download PDF

Info

Publication number
WO2006130190A3
WO2006130190A3 PCT/US2006/004349 US2006004349W WO2006130190A3 WO 2006130190 A3 WO2006130190 A3 WO 2006130190A3 US 2006004349 W US2006004349 W US 2006004349W WO 2006130190 A3 WO2006130190 A3 WO 2006130190A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
proline
compositions
plants
compared
described
Prior art date
Application number
PCT/US2006/004349
Other languages
French (fr)
Other versions
WO2006130190A2 (en )
Inventor
Martin B Dickman
Original Assignee
Martin B Dickman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401Proline; Derivatives thereof, e.g. captopril

Abstract

The discovery that proline is a potent antioxidant and inhibitor of programmed cell death is described, as are proline-containing compositions and methods for using such compositions in response to, or in advance of, experiencing oxidative stress. These compositions and methods find application across the animal and plant kingdoms. Transgenic plants exhibiting altered intracellular proline levels, as compared to plants lacking such an alteration, are also described, as are transgenic plants that exhibit altered expression of one or more genes involved in the metabolism of reactive oxygen species (ROS), as compared to unmodified plants.
PCT/US2006/004349 2005-02-07 2006-02-07 Proline suppresses apoptosis WO2006130190A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US65157105 true 2005-02-07 2005-02-07
US60/651,571 2005-02-07

Publications (2)

Publication Number Publication Date
WO2006130190A2 true WO2006130190A2 (en) 2006-12-07
WO2006130190A3 true true WO2006130190A3 (en) 2007-01-25

Family

ID=37482104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/004349 WO2006130190A3 (en) 2005-02-07 2006-02-07 Proline suppresses apoptosis

Country Status (1)

Country Link
WO (1) WO2006130190A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170348266A1 (en) * 2014-11-13 2017-12-07 Buck Institute For Research On Aging Inhibition of proline catabolism for the treatment of cancer and other therapeutic applications

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins

Also Published As

Publication number Publication date Type
WO2006130190A2 (en) 2006-12-07 application

Similar Documents

Publication Publication Date Title
Shao et al. Higher plant antioxidants and redox signaling under environmental stresses
Rai et al. Developing stress tolerant plants through in vitro selection—an overview of the recent progress
Kibinza et al. Sunflower seed deterioration as related to moisture content during ageing, energy metabolism and active oxygen species scavenging
Hernández et al. Short‐term effects of salt stress on antioxidant systems and leaf water relations of pea leaves
Eraslan et al. Impact of exogenous salicylic acid on the growth, antioxidant activity and physiology of carrot plants subjected to combined salinity and boron toxicity
Ali et al. Effects of temperature on oxidative stress defense systems, lipid peroxidation and lipoxygenase activity in Phalaenopsis
Chen et al. Salinity tolerance of Populus
Solecka et al. Phenylpropanoid deficiency affects the course of plant acclimation to cold
Manivannan et al. Changes in antioxidant metabolism of Vigna unguiculata (L.) Walp. by propiconazole under water deficit stress
Stratmann Ultraviolet-B radiation co-opts defense signaling pathways
Munné-Bosch et al. Die and let live: leaf senescence contributes to plant survival under drought stress
Ozkur et al. Physiochemical and antioxidant responses of the perennial xerophyte Capparis ovata Desf. to drought
Wang et al. Long‐term exogenous application of melatonin delays drought‐induced leaf senescence in apple
Agati et al. Flavonoids as antioxidants in plants: location and functional significance
Chaitanya et al. Role of superoxide, lipid peroxidation and superoxide dismutase in membrane perturbation during loss of viability in seeds of Shorea robusta Gaertn. f.
Qureshi et al. Responses of Artemisia annua L. to lead and salt-induced oxidative stress
Garnier et al. Cadmium affects tobacco cells by a series of three waves of reactive oxygen species that contribute to cytotoxicity
Arnao et al. Protective effect of melatonin against chlorophyll degradation during the senescence of barley leaves
Ben Ahmed et al. Exogenous proline effects on photosynthetic performance and antioxidant defense system of young olive tree
Evans Aerenchyma formation
Reddy et al. Drought-induced responses of photosynthesis and antioxidant metabolism in higher plants
Gould et al. Do anthocyanins function as antioxidants in leaves? Imaging of H2O2 in red and green leaves after mechanical injury
Amor et al. Response of antioxidant systems to NaCl stress in the halophyte Cakile maritima
Bhattacharjee The language of reactive oxygen species signaling in plants
Ahmed et al. Genotypic differences in physiological characteristics in the tolerance to drought and salinity combined stress between Tibetan wild and cultivated barley

Legal Events

Date Code Title Description
NENP Non-entry into the national phase in:

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 06784315

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 06784315

Country of ref document: EP

Kind code of ref document: A2