WO2006118543A1 - Novel water-soluble nanocrystals comprising a low molecular weight coating reagent, and methods of preparing the same - Google Patents

Novel water-soluble nanocrystals comprising a low molecular weight coating reagent, and methods of preparing the same Download PDF

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Publication number
WO2006118543A1
WO2006118543A1 PCT/SG2005/000138 SG2005000138W WO2006118543A1 WO 2006118543 A1 WO2006118543 A1 WO 2006118543A1 SG 2005000138 W SG2005000138 W SG 2005000138W WO 2006118543 A1 WO2006118543 A1 WO 2006118543A1
Authority
WO
WIPO (PCT)
Prior art keywords
nanocrystal
group
coupling
reagent
capping reagent
Prior art date
Application number
PCT/SG2005/000138
Other languages
English (en)
French (fr)
Inventor
Mingyong Han
Fuke Wang
Original Assignee
Agency For Science, Technology And Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency For Science, Technology And Research filed Critical Agency For Science, Technology And Research
Priority to PCT/SG2005/000138 priority Critical patent/WO2006118543A1/en
Priority to US11/913,671 priority patent/US20090042032A1/en
Priority to EP05734497A priority patent/EP1883820A4/en
Priority to CNA2005800502098A priority patent/CN101208605A/zh
Priority to JP2008509982A priority patent/JP2008540142A/ja
Publication of WO2006118543A1 publication Critical patent/WO2006118543A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B19/00—Selenium; Tellurium; Compounds thereof
    • C01B19/007—Tellurides or selenides of metals
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C09K11/025—Use of particular materials as binders, particle coatings or suspension media therefor non-luminescent particle coatings or suspension media
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/56—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing sulfur
    • C09K11/562—Chalcogenides
    • C09K11/565—Chalcogenides with zinc cadmium
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/88—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing selenium, tellurium or unspecified chalcogen elements
    • C09K11/881—Chalcogenides
    • C09K11/883—Chalcogenides with zinc or cadmium
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/80—Particles consisting of a mixture of two or more inorganic phases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Definitions

  • the PCT publication WO 00/17656 discloses core-shell nanocrystals which are capped with a carboxyl acid or sulfonic acid compound of the formula SH(CH 2 ) n -COOH and SH(CH 2 ) n -SO 3 H, respectively in order to render the nanocrystals water soluble.
  • the PCT application WO 00/29617 and British patent application GB 2342651 describe that organic acids such as mercaptoacetic acid or mercapto-undecanoic acid are attached to the surface of nanocrystals to render them water soluble and suitable for conjugation of biomolecules such as proteins or nucleic acids.
  • GB 2342651 also describes the use of trioctylphosphine as capping material that is supposed to confer water solubility of the nanocrystals.
  • the elements M1 and M2 comprised therein are preferably independently selected from the group consisting of Zn, Cd and Hg.
  • the element A of the group Vl of the PSE in these ternary alloys is preferably selected from the group consisting of S, Se and Te.
  • any coupling agent that activates the coupling groups in the capping reagent can be used, as long as the coupling agent is chemically compatible with the capping reagent used for forming the first and the coating reagent used for forming the second layer, meaning that the coupling agent does not react with them to alter their structure.
  • the coupling agent is chemically compatible with the capping reagent used for forming the first and the coating reagent used for forming the second layer, meaning that the coupling agent does not react with them to alter their structure.
  • no unreacted coupling agent should be present in the nanocrystal as the coupling agent molecules should be completely displaced by coating reagent molecules.
PCT/SG2005/000138 2005-05-04 2005-05-04 Novel water-soluble nanocrystals comprising a low molecular weight coating reagent, and methods of preparing the same WO2006118543A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
PCT/SG2005/000138 WO2006118543A1 (en) 2005-05-04 2005-05-04 Novel water-soluble nanocrystals comprising a low molecular weight coating reagent, and methods of preparing the same
US11/913,671 US20090042032A1 (en) 2005-05-04 2005-05-04 Novel water-soluble nanocrystals comprising a low molecular weight coating reagent, and methods of preparing the same
EP05734497A EP1883820A4 (en) 2005-05-04 2005-05-04 NEW WATER-SOLUBLE NANOCRYLS WITH A LOW-MOLECULAR COATING RUBBER AND METHOD FOR THE PRODUCTION THEREOF
CNA2005800502098A CN101208605A (zh) 2005-05-04 2005-05-04 含有低分子量涂布剂的新型水溶性纳米晶及其制备方法
JP2008509982A JP2008540142A (ja) 2005-05-04 2005-05-04 低分子量コーティング試薬を含む新規な水溶性ナノ結晶、およびその調製方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SG2005/000138 WO2006118543A1 (en) 2005-05-04 2005-05-04 Novel water-soluble nanocrystals comprising a low molecular weight coating reagent, and methods of preparing the same

Publications (1)

Publication Number Publication Date
WO2006118543A1 true WO2006118543A1 (en) 2006-11-09

Family

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PCT/SG2005/000138 WO2006118543A1 (en) 2005-05-04 2005-05-04 Novel water-soluble nanocrystals comprising a low molecular weight coating reagent, and methods of preparing the same

Country Status (5)

Country Link
US (1) US20090042032A1 (US20090042032A1-20090212-C00018.png)
EP (1) EP1883820A4 (US20090042032A1-20090212-C00018.png)
JP (1) JP2008540142A (US20090042032A1-20090212-C00018.png)
CN (1) CN101208605A (US20090042032A1-20090212-C00018.png)
WO (1) WO2006118543A1 (US20090042032A1-20090212-C00018.png)

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WO2008070459A2 (en) * 2006-11-22 2008-06-12 Alnis Biosciences, Inc. Coated nanoparticles for aqueous systems
US20080283801A1 (en) * 2007-05-15 2008-11-20 Tatsuya Ryowa Group 13 nitride phosphor and method of preparing the same
WO2010043053A1 (en) * 2008-10-15 2010-04-22 National Research Council Of Canada Single-domain antibody functionalized quantum dots for cellular imaging of cancer cells
US7803423B2 (en) 2004-04-30 2010-09-28 Nanoco Technologies Limited Preparation of nanoparticle materials
US7867557B2 (en) 2005-08-12 2011-01-11 Nanoco Technologies Limited Nanoparticles
US7867556B2 (en) 2005-10-28 2011-01-11 Nanoco Technologies Limited Controlled preparation of nanoparticle materials
JP2012500175A (ja) * 2008-08-21 2012-01-05 リミテッド ライアビリティ カンパニー ザ “ナノテックードゥブナ” トライアル センター フォー サイエンス アンド テクノロジー 半導体量子ドットの合成方法
US8337720B2 (en) 2008-02-25 2012-12-25 Nanoco Technologies, Ltd. Semiconductor nanoparticle capping agents
US8394663B2 (en) 2007-04-25 2013-03-12 Nanoco Technologies, Ltd. Hybrid photovoltaic cells and related methods
US8394976B2 (en) 2008-11-04 2013-03-12 Nanoco Technologies, Ltd. Surface functionalised nanoparticles
US8563348B2 (en) 2007-04-18 2013-10-22 Nanoco Technologies Ltd. Fabrication of electrically active films based on multiple layers
US8597730B2 (en) 2008-08-07 2013-12-03 Nanoco Technologies Ltd. Surface functionalised nanoparticles
US8741177B2 (en) 2008-07-19 2014-06-03 Nanoco Technologies Ltd. Method for producing aqueous compatible nanoparticles
US8784701B2 (en) 2007-11-30 2014-07-22 Nanoco Technologies Ltd. Preparation of nanoparticle material
US8847197B2 (en) 2009-09-23 2014-09-30 Nanoco Technologies Ltd. Semiconductor nanoparticle-based materials
US8859442B2 (en) 2010-04-01 2014-10-14 Nanoco Technologies Ltd. Encapsulated nanoparticles
US8921827B2 (en) 2008-11-19 2014-12-30 Nanoco Technologies, Ltd. Semiconductor nanoparticle-based light-emitting devices and associated materials and methods
US8957401B2 (en) 2009-09-23 2015-02-17 Nanoco Technologies, Ltd Semiconductor nanoparticle-based materials
WO2016020337A1 (en) * 2014-08-04 2016-02-11 Rhodia Operations Modified phosphors and compositions thereof

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WO2007102799A2 (en) * 2006-01-20 2007-09-13 Agency For Science, Technology And Research Synthesis of alloyed nanocrystals in aqueous or water-soluble solvents
CN101668697B (zh) * 2007-03-30 2013-03-27 科技研究局 疏水量子点的封装
CN101590531B (zh) * 2009-07-13 2011-02-23 中国科学院化学研究所 一种制备金属/有机小分子核/壳型一维纳米复合材料的方法
KR101740429B1 (ko) 2010-09-15 2017-05-26 삼성전자주식회사 공액구조의 표면 리간드를 함유하는 양자점, 이를 포함하는 유기전계발광소자 및 태양전지
CN102206487B (zh) * 2011-04-21 2013-08-21 江苏迈健生物科技发展有限公司 一种羧基化法β-环糊精修饰的低毒性功能化量子点及其制备方法
WO2013093631A2 (en) 2011-12-22 2013-06-27 Nanoco Technologies, Inc. Surface modified nanoparticles
US20170271563A1 (en) * 2016-03-15 2017-09-21 Chris Durgan Method and apparatus for controlled semiconductor growth during synthesis of quantum dot materials
CN111762809B (zh) * 2020-06-18 2023-11-03 苏州大学 一种铅氧族化合物二聚体纳米晶、导电薄膜及制备方法与应用

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US8524365B2 (en) 2004-04-30 2013-09-03 Nanoco Technologies Ltd. Preparation of nanoparticle materials
US7803423B2 (en) 2004-04-30 2010-09-28 Nanoco Technologies Limited Preparation of nanoparticle materials
US7985446B2 (en) 2004-04-30 2011-07-26 Nanoco Technologies Limited Preparation of nanoparticle materials
US8062703B2 (en) 2004-04-30 2011-11-22 Nanoco Technologies Ltd. Preparation of nanoparticle materials
US7867557B2 (en) 2005-08-12 2011-01-11 Nanoco Technologies Limited Nanoparticles
US7867556B2 (en) 2005-10-28 2011-01-11 Nanoco Technologies Limited Controlled preparation of nanoparticle materials
WO2008070459A2 (en) * 2006-11-22 2008-06-12 Alnis Biosciences, Inc. Coated nanoparticles for aqueous systems
WO2008070459A3 (en) * 2006-11-22 2008-08-07 Alnis Biosciences Inc Coated nanoparticles for aqueous systems
US8563348B2 (en) 2007-04-18 2013-10-22 Nanoco Technologies Ltd. Fabrication of electrically active films based on multiple layers
US8394663B2 (en) 2007-04-25 2013-03-12 Nanoco Technologies, Ltd. Hybrid photovoltaic cells and related methods
US8123979B2 (en) * 2007-05-15 2012-02-28 Sharp Kabushiki Kaisha Group 13 nitride phosphor and method of preparing the same
US20080283801A1 (en) * 2007-05-15 2008-11-20 Tatsuya Ryowa Group 13 nitride phosphor and method of preparing the same
US8784701B2 (en) 2007-11-30 2014-07-22 Nanoco Technologies Ltd. Preparation of nanoparticle material
US9251922B2 (en) 2007-11-30 2016-02-02 Nanoco Technologies, Ltd. Preparation of nanoparticle material
US8337720B2 (en) 2008-02-25 2012-12-25 Nanoco Technologies, Ltd. Semiconductor nanoparticle capping agents
US8741177B2 (en) 2008-07-19 2014-06-03 Nanoco Technologies Ltd. Method for producing aqueous compatible nanoparticles
US8597730B2 (en) 2008-08-07 2013-12-03 Nanoco Technologies Ltd. Surface functionalised nanoparticles
JP2012500175A (ja) * 2008-08-21 2012-01-05 リミテッド ライアビリティ カンパニー ザ “ナノテックードゥブナ” トライアル センター フォー サイエンス アンド テクノロジー 半導体量子ドットの合成方法
WO2010043053A1 (en) * 2008-10-15 2010-04-22 National Research Council Of Canada Single-domain antibody functionalized quantum dots for cellular imaging of cancer cells
US8394976B2 (en) 2008-11-04 2013-03-12 Nanoco Technologies, Ltd. Surface functionalised nanoparticles
US8921827B2 (en) 2008-11-19 2014-12-30 Nanoco Technologies, Ltd. Semiconductor nanoparticle-based light-emitting devices and associated materials and methods
US8847197B2 (en) 2009-09-23 2014-09-30 Nanoco Technologies Ltd. Semiconductor nanoparticle-based materials
US8957401B2 (en) 2009-09-23 2015-02-17 Nanoco Technologies, Ltd Semiconductor nanoparticle-based materials
US9543481B2 (en) 2009-09-23 2017-01-10 Nanoco Technologies Ltd. Semiconductor nanoparticle-based materials
US8859442B2 (en) 2010-04-01 2014-10-14 Nanoco Technologies Ltd. Encapsulated nanoparticles
US9159590B2 (en) 2010-04-01 2015-10-13 Nanoco Technologies, Ltd. Encapsulated nanoparticles
WO2016020337A1 (en) * 2014-08-04 2016-02-11 Rhodia Operations Modified phosphors and compositions thereof

Also Published As

Publication number Publication date
JP2008540142A (ja) 2008-11-20
EP1883820A4 (en) 2010-06-16
EP1883820A1 (en) 2008-02-06
US20090042032A1 (en) 2009-02-12
CN101208605A (zh) 2008-06-25

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