WO2006116292A3 - Methods for reducing the immunogenicity of cytokines and removal of cell surface markers - Google Patents

Methods for reducing the immunogenicity of cytokines and removal of cell surface markers Download PDF

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Publication number
WO2006116292A3
WO2006116292A3 PCT/US2006/015441 US2006015441W WO2006116292A3 WO 2006116292 A3 WO2006116292 A3 WO 2006116292A3 US 2006015441 W US2006015441 W US 2006015441W WO 2006116292 A3 WO2006116292 A3 WO 2006116292A3
Authority
WO
WIPO (PCT)
Prior art keywords
immunogenicity
cytokines
removal
reducing
methods
Prior art date
Application number
PCT/US2006/015441
Other languages
French (fr)
Other versions
WO2006116292A2 (en
Inventor
Fiona A Harding
Original Assignee
Genencor Int
Fiona A Harding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor Int, Fiona A Harding filed Critical Genencor Int
Priority to CN200680010757.2A priority Critical patent/CN101151275B/en
Priority to JP2008508992A priority patent/JP2008538921A/en
Priority to EP06751224.4A priority patent/EP1874812B1/en
Priority to DK06751224.4T priority patent/DK1874812T3/en
Priority to US11/885,535 priority patent/US20090035798A1/en
Publication of WO2006116292A2 publication Critical patent/WO2006116292A2/en
Publication of WO2006116292A3 publication Critical patent/WO2006116292A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5437—IL-13

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides means to assess the comparative allergenicity of proteases. In particular, the present invention provides means to qualitatively assess the potential for any protease to induce an allergic response in humans. In addition, the present invention provides means to select proteases with reduced allergenicity for use in various applications.
PCT/US2006/015441 2005-04-27 2006-04-24 Methods for reducing the immunogenicity of cytokines and removal of cell surface markers WO2006116292A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN200680010757.2A CN101151275B (en) 2005-04-27 2006-04-24 Methods for reducing the immunogenicity of cytokines and removal of cell surface markers
JP2008508992A JP2008538921A (en) 2005-04-27 2006-04-24 Methods for reducing cytokine immunogenicity and removing cell surface markers
EP06751224.4A EP1874812B1 (en) 2005-04-27 2006-04-24 Methods of assessing allergenicity of proteases
DK06751224.4T DK1874812T3 (en) 2005-04-27 2006-04-24 Methods for Determining Allergenicity of Proteases
US11/885,535 US20090035798A1 (en) 2005-04-27 2006-04-24 Methods for Reducing the Immunogenicity of Cytokines and Removal of Cell Surface Markers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67515605P 2005-04-27 2005-04-27
US60/675,156 2005-04-27

Publications (2)

Publication Number Publication Date
WO2006116292A2 WO2006116292A2 (en) 2006-11-02
WO2006116292A3 true WO2006116292A3 (en) 2007-03-01

Family

ID=37037050

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/015441 WO2006116292A2 (en) 2005-04-27 2006-04-24 Methods for reducing the immunogenicity of cytokines and removal of cell surface markers

Country Status (6)

Country Link
US (1) US20090035798A1 (en)
EP (1) EP1874812B1 (en)
JP (1) JP2008538921A (en)
CN (1) CN101151275B (en)
DK (1) DK1874812T3 (en)
WO (1) WO2006116292A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2412802A1 (en) * 2010-07-29 2012-02-01 TXCell IL-13 producing TR1-like cells and use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000048462A1 (en) * 1999-02-18 2000-08-24 Faustman Denise L Method for inhibiting transplant rejection
US6232088B1 (en) * 1995-02-08 2001-05-15 Phairson Medical, Inc. Treatment and prevention of immune rejection reactions
WO2002077187A2 (en) * 2001-03-23 2002-10-03 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
WO2003073068A2 (en) * 2002-02-26 2003-09-04 Genencor International, Inc. Population based assessments and means to rank the relative immunogenicity of proteins
WO2003104263A2 (en) * 2002-05-01 2003-12-18 Genencor International, Inc. Cytokines and cytokine receptors with reduced immunogenicity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU782044B2 (en) * 1999-10-15 2005-06-30 Novozymes A/S A method for the assessment of allergenicity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232088B1 (en) * 1995-02-08 2001-05-15 Phairson Medical, Inc. Treatment and prevention of immune rejection reactions
WO2000048462A1 (en) * 1999-02-18 2000-08-24 Faustman Denise L Method for inhibiting transplant rejection
WO2002077187A2 (en) * 2001-03-23 2002-10-03 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
WO2003073068A2 (en) * 2002-02-26 2003-09-04 Genencor International, Inc. Population based assessments and means to rank the relative immunogenicity of proteins
WO2003104263A2 (en) * 2002-05-01 2003-12-18 Genencor International, Inc. Cytokines and cytokine receptors with reduced immunogenicity

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHEUNSUK S.: "Analysis of the IDDM Candidate Gene Prss16 in NOD and NON Mice", DEVELOPMENTAL IMMUNOLOGY, vol. 9, no. 4, 2002, pages 183 - 186, XP009074570 *
MURALI R. ET AL: "Altered levels of urokinase on monocytes and in serum of children with AIDS; effects on lymphocyte activation and surface marker expression", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 64, 1998, pages 198 - 202, XP000993187 *
SHAKIB F.,GOUGH L.: "The proteolytic activity of Der p 1 selectively enhances IgE synthesis: a link between allerneicity and cyteine protease activity", CLINICAL AND EXPERIMENTAL ALLERGY, vol. 30, 2000, pages 751 - 752, XP002402426 *
STEWART G A ET AL: "Endogenous function and biological significance of aeroallergens: an update", CURR OPIN ALLERGY CLIN IMMUNOL, vol. 1, no. 1, 2001, pages 95 - 103, XP009074622 *
WESTON G S ET AL: "GRANZYMES AS POTENTIAL TARGETS FOR RATIONAL DRUG DESIGN", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 3, no. 1, 1996, pages 37 - 46, XP002913206, ISSN: 0929-8673 *
WIDMER F ET AL: "Substrate preference profiles of proteases released by allergenic pollens", CLINICAL AND EXPERIMENTAL ALLERGY, vol. 30, 2000, pages 571 - 576, XP002406155 *
WOOD P.A., KAATTARI S.L.: "Enhanced immunogenicity of Renibacterium salmoninarium in chinook salmon after removal of teh bacterial cell surface-associated 57 kDa protein", DISEASES OF AQUATIC ORGANISMS, vol. 25, 1996, pages 71 - 79, XP009073486 *
XUE A ET AL: "HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN'-induced hypersensitivity", CLINICAL IMMUNOLOGY, vol. 117, 2005, pages 302 - 315, XP002406156 *

Also Published As

Publication number Publication date
DK1874812T3 (en) 2013-12-09
WO2006116292A2 (en) 2006-11-02
CN101151275A (en) 2008-03-26
JP2008538921A (en) 2008-11-13
EP1874812B1 (en) 2013-09-04
CN101151275B (en) 2013-07-10
US20090035798A1 (en) 2009-02-05
EP1874812A2 (en) 2008-01-09

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