WO2006104912A3 - C-met mutations in lung cancer - Google Patents

C-met mutations in lung cancer Download PDF

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Publication number
WO2006104912A3
WO2006104912A3 PCT/US2006/010851 US2006010851W WO2006104912A3 WO 2006104912 A3 WO2006104912 A3 WO 2006104912A3 US 2006010851 W US2006010851 W US 2006010851W WO 2006104912 A3 WO2006104912 A3 WO 2006104912A3
Authority
WO
WIPO (PCT)
Prior art keywords
lung cancer
met mutations
met
mutations
cancer cells
Prior art date
Application number
PCT/US2006/010851
Other languages
French (fr)
Other versions
WO2006104912A2 (en
WO2006104912A9 (en
Inventor
Robert L Yauch
Original Assignee
Genentech Inc
Robert L Yauch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Robert L Yauch filed Critical Genentech Inc
Priority to JP2008503237A priority Critical patent/JP2008533991A/en
Priority to EP06739565A priority patent/EP1861513A2/en
Priority to AU2006229990A priority patent/AU2006229990A1/en
Priority to CA002600283A priority patent/CA2600283A1/en
Priority to BRPI0612169-1A priority patent/BRPI0612169A2/en
Priority to MX2007011650A priority patent/MX2007011650A/en
Publication of WO2006104912A2 publication Critical patent/WO2006104912A2/en
Publication of WO2006104912A3 publication Critical patent/WO2006104912A3/en
Publication of WO2006104912A9 publication Critical patent/WO2006104912A9/en
Priority to IL185666A priority patent/IL185666A0/en

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides methods and compositions useful for detecting mutations in c-met in lung cancer cells.
PCT/US2006/010851 2005-03-25 2006-03-24 C-met mutations in lung cancer WO2006104912A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2008503237A JP2008533991A (en) 2005-03-25 2006-03-24 C-MET mutation in lung cancer
EP06739565A EP1861513A2 (en) 2005-03-25 2006-03-24 C-met mutations in lung cancer
AU2006229990A AU2006229990A1 (en) 2005-03-25 2006-03-24 C-met mutations in lung cancer
CA002600283A CA2600283A1 (en) 2005-03-25 2006-03-24 C-met mutations in lung cancer
BRPI0612169-1A BRPI0612169A2 (en) 2005-03-25 2006-03-24 prognostic methods, detection, distinguishing, identification, determination and monitoring methods related to lung cancer, methods for amplifying a nucleic acid encoding human c-met, lung cancer biomarkers, cancer imaging agents polynucleotides, antigen binding agents, assemblies, computer readable media and kits and / or articles of manufacture
MX2007011650A MX2007011650A (en) 2005-03-25 2006-03-24 C-met mutations in lung cancer.
IL185666A IL185666A0 (en) 2005-03-25 2007-09-03 C-met mutations in lung cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66531705P 2005-03-25 2005-03-25
US60/665,317 2005-03-25

Publications (3)

Publication Number Publication Date
WO2006104912A2 WO2006104912A2 (en) 2006-10-05
WO2006104912A3 true WO2006104912A3 (en) 2007-01-11
WO2006104912A9 WO2006104912A9 (en) 2007-03-15

Family

ID=36512935

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/010851 WO2006104912A2 (en) 2005-03-25 2006-03-24 C-met mutations in lung cancer

Country Status (13)

Country Link
US (2) US20060263808A1 (en)
EP (1) EP1861513A2 (en)
JP (1) JP2008533991A (en)
KR (1) KR20080004514A (en)
CN (1) CN101180410A (en)
AU (1) AU2006229990A1 (en)
BR (1) BRPI0612169A2 (en)
CA (1) CA2600283A1 (en)
IL (1) IL185666A0 (en)
MX (1) MX2007011650A (en)
RU (1) RU2007139516A (en)
WO (1) WO2006104912A2 (en)
ZA (1) ZA200707946B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7615529B2 (en) * 2005-03-25 2009-11-10 Genentech, Inc. Methods and compositions for modulating hyperstabilized c-met
US20080160533A1 (en) * 2006-11-30 2008-07-03 Abbott Laboratories Assay for prediction of response to Met antagonists
US20100062441A1 (en) * 2007-03-15 2010-03-11 Ravi Salgia C-met mutations and uses thereof
JP2013507989A (en) 2009-10-26 2013-03-07 アボット・ラボラトリーズ Detection of chromosomal abnormalities associated with prognosis of non-small cell lung cancer
SG194932A1 (en) 2011-06-30 2013-12-30 Genentech Inc Anti-c-met antibody formulations
KR20130036993A (en) * 2011-10-05 2013-04-15 삼성전자주식회사 Antibodies specifically binding to epitope in sema domain of c-met
KR101753833B1 (en) 2012-01-09 2017-07-05 사회복지법인 삼성생명공익재단 Method for detection of chronic myeloid leukemia gene using a cleavable probe
KR101404682B1 (en) 2012-01-09 2014-06-10 사회복지법인 삼성생명공익재단 Method for detection of c-Met gene using a cleavable probe
KR101938698B1 (en) 2012-07-23 2019-01-16 삼성전자주식회사 Use of Cbl as a biomarker for identifying a subject for application of anti c-Met antibodies
CN107002119A (en) 2014-03-24 2017-08-01 豪夫迈·罗氏有限公司 Treatment of cancer and the former and associating that HGF is expressed using C MET antagonists
US11035860B2 (en) * 2014-11-20 2021-06-15 Stichting Katholieke Universiteit Auto-active and intracellular mutant of MET
US20180057595A1 (en) 2015-03-16 2018-03-01 Celldex Therapeutics, Inc. Anti-MET Antibodies and Methods of Use Thereof
CN105713987A (en) * 2016-04-25 2016-06-29 北京福安华生物科技有限公司 Primers, probe and kit for detecting human MET gene 14 exon splicing mutation
KR101977351B1 (en) * 2016-09-21 2019-05-10 사회복지법인 삼성생명공익재단 Composition for predicting resistance or susceptibility to anticancer drugs
CN106757379B (en) * 2016-12-20 2018-08-28 上海赛安生物医药科技股份有限公司 Lung cancer polygenic variation library constructing method
GB201714748D0 (en) * 2017-09-13 2017-10-25 Univ Oxford Innovation Ltd Single-molecule phenotyping and sequencing of nucleic acid molecules
CN108315431A (en) * 2018-05-04 2018-07-24 良培基因生物科技（武汉）有限公司 Digital pcr technology detects primer, probe and its detection method of c-MET gene magnifications
CN108893536B (en) * 2018-07-13 2022-02-15 江苏省人民医院（南京医科大学第一附属医院） Method and kit for detecting copy number variation of c-MET gene from human peripheral blood CTC
CN108929908A (en) * 2018-07-17 2018-12-04 张丽英 A kind of detection method skipped based on digital pcr platform c-MET gene Exon14

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038125A1 (en) * 1996-04-05 1997-10-16 Thomas Jefferson University Methods for the diagnosis and prognosis of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2258153C (en) * 1996-07-03 2004-08-17 Genentech, Inc. Hepatocyte growth factor receptor agonists and uses thereof
AU2003230874A1 (en) * 2002-04-16 2003-11-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
PL1636593T3 (en) * 2003-06-06 2009-08-31 Genentech Inc Modulating the interaction between hgf beta chain and c-met
AU2004298483A1 (en) * 2003-12-11 2005-06-30 Genentech, Inc. Methods and compositions for inhibiting c-met dimerization and activation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038125A1 (en) * 1996-04-05 1997-10-16 Thomas Jefferson University Methods for the diagnosis and prognosis of cancer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DIETRICH SASCHA ET AL: "Role of c-MET in upper aerodigestive malignancies - From biology to novel therapies", JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, vol. 24, no. 3, 2005, pages 149 - 162, XP009067602, ISSN: 0731-8898 *
MA P C ET AL: "c-Met: Structure, functions and potential for therapeutic inhibition", CANCER AND METASTASIS REVIEWS, KLUWER ACADEMIC PUBLISHERS, DORDRECHT, NL, vol. 22, no. 4, December 2003 (2003-12-01), pages 309 - 325, XP002328700, ISSN: 0167-7659 *
MA PATRICK C ET AL: "c-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions.", CANCER RESEARCH, vol. 63, no. 19, 1 October 2003 (2003-10-01), pages 6272 - 6281, XP002384471, ISSN: 0008-5472 *
MA PATRICK C ET AL: "Functional expression and mutations of c-met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer", CANCER RESEARCH, vol. 65, no. 4, 15 February 2005 (2005-02-15), pages 1479 - 1488, XP002384470, ISSN: 0008-5472 *
MAULIK GAUTAM ET AL: "Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition", CYTOKINE AND GROWTH FACTOR REVIEWS, OXFORD, GB, vol. 13, no. 1, February 2002 (2002-02-01), pages 41 - 59, XP002295576, ISSN: 1359-6101 *

Also Published As

Publication number Publication date
CA2600283A1 (en) 2006-10-05
EP1861513A2 (en) 2007-12-05
KR20080004514A (en) 2008-01-09
WO2006104912A2 (en) 2006-10-05
RU2007139516A (en) 2009-04-27
MX2007011650A (en) 2008-01-16
AU2006229990A1 (en) 2006-10-05
US20090155807A1 (en) 2009-06-18
WO2006104912A9 (en) 2007-03-15
IL185666A0 (en) 2008-01-06
CN101180410A (en) 2008-05-14
BRPI0612169A2 (en) 2010-10-19
JP2008533991A (en) 2008-08-28
AU2006229990A2 (en) 2006-10-05
ZA200707946B (en) 2009-02-25
US20060263808A1 (en) 2006-11-23

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