WO2006104464A1 - Cdte/gsh core-shell quantum dots - Google Patents
Cdte/gsh core-shell quantum dots Download PDFInfo
- Publication number
- WO2006104464A1 WO2006104464A1 PCT/SG2006/000003 SG2006000003W WO2006104464A1 WO 2006104464 A1 WO2006104464 A1 WO 2006104464A1 SG 2006000003 W SG2006000003 W SG 2006000003W WO 2006104464 A1 WO2006104464 A1 WO 2006104464A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- solution
- precursor
- gsh
- core
- cadmium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
- C09K11/88—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing selenium, tellurium or unspecified chalcogen elements
- C09K11/881—Chalcogenides
- C09K11/883—Chalcogenides with zinc or cadmium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
Definitions
- the present invention relates to quantum dots.
- QDs Quantum dots
- QDs have wide applications and are currently commercially available.
- QDs may be useful in optoelectronic and photovoltaic devices, optical amplifier media for telecommunication networks, and for bio-labeling.
- a QD is a nanocrystal particle having a semiconductor core and a semiconductor shell outside the core.
- the size of the QDs is typically from 2 to 20 nm. Due to their small sizes, QDs have a well-defined fluorescence emission spectrum.
- QDs can have a thiol shell and are often coated with a suitable material, such as polymers and silica.
- the shell and the polymer coating are typically used to improve or alter the properties of the QDs, such as the optical properties, stability, and affinity to another object of the QDs. For instance, the shell and coating may improve the fluorescence quantum yield of the QDs. Quantum yield is the number of photons emitted per absorbed photon and is often a critical property, such as when the QDs are used as labels.
- thiol- capped QDs have low quantum yield typically in the range of 1 to 10%.
- the quantum yield can be improved by various post-formation treatments such as photochemical etching, size selective precipitation and long-term illumination, the purified or activated QDs have a tendency to agglomerate during these treatments, thus forming larger sized particles.
- CdSe QDs have been synthesized in water using glutathione as a stabilizing molecule, as reported in Monika Baumle et al. ("Baumle”), "Highly Fluorescent Streptavidin-Coated CdSe nanoparticles: Preparation in Water, Characterization, and Micropatterning," Langmuir, vol. 20, pp. 3838-3831, 2004, the contents of which are incorporated herein by reference.
- a problem with the technique disclosed in Baumle is that the CdSe QDs have a relatively low quantum yield of 16%.
- Another problem with this technique is that the QDs prepared are tunable only in a narrow range of wavelengths, because the QDs formed tend to aggregate when they grow to sizes larger than about 3 nm.
- a method of synthesizing quantum dots in this method, a solution comprising a telluride (Te) precursor and a cadmium (Cd) precursor is provided. Nanocrystals comprising CdTe are grown in the solution. Glutathione (GSH) is also introduced to the solution to form shells covering the nanocrystals. The nanocrystals and the shells form quantum dots each having a core comprising CdTe and a shell comprising GSH.
- a quantum dot comprising a nanocrystal core and a shell covering the core.
- the core comprises cadmium telluride (CdTe).
- the shell comprises glutathione (GSH).
- a solution for forming quantum dots each comprising a CdTe core and a GSH shell.
- the solution comprises a telluride (Te) precursor and a cadmium (Cd) precursor for forming CdTe cores, and glutathione (GSH) for forming shells covering the CdTe cores.
- Te telluride
- Cd cadmium
- GSH glutathione
- quantum dots are formed in a solution comprising a telluride (Te) precursor, a cadmium (Cd) precursor, and glutathione (GSH), such that each of the quantum dots has a core comprising CdTe and a shell comprising GSH.
- Te telluride
- Cd cadmium
- GSH glutathione
- the quantum dots can have fluorescence quantum yields higher than about 16%, such as up to about 45%.
- the quantum dots can also have diameters ranging from about 3.8 nm to about 6 nm.
- FIG. 1 is a schematic diagram of a quantum dot
- FIG. 2 is a line graph of absorption and fluorescence spectra;
- FIG. 3 is a graph of fluorescence emission peak wavelength as a function of heating time;
- FIG. 4 is a graph of quantum yield and bandwidth as a function of wavelength
- FIG. 5 is a graph of size distribution measured by Dynamic Light Scattering (DLS);
- FIG. 6 is a transmission electron microscopy (TEM) image of sample quantum dots
- FIG. 7 is a line graph of X-ray Diffraction (XRD) patterns of two types of quantum dots
- FIG. 8 is a line graph of fluorescence intensity as a function of pH
- FIG. 9A is a confocal fluorescence image of cells labeled with quantum dots.
- FIG. 9B is a transmission image of cells labeled with quantum dots.
- FIG. 1 illustrates a quantum dot (QD) 10, exemplary of embodiments of the present invention.
- Quantum dots are also referred to by various other names such as nanocrystals, nanoparticles, and quantum bits.
- Quantum dot 10 comprises a core 12 and a shell 14.
- Core 12 includes a semiconductor nanocrystal, such as cadmium telluride (CdTe), which can have a zinc blende lattice structure.
- Core 12 has a diameter from about 2.8 nm to about 5 nm.
- Shell 14 includes a stabilizing agent glutathione (GSH) and has a thickness of about 0.5 nm. The external diameter of QD 10 is therefore about 3.8 to about 6 nm.
- the sizes of QDs can be measured using various techniques, including conventional techniques such as X-ray diffraction (XRD).
- XRD X-ray diffraction
- the sizes of QDs can also be estimated based on the known relationship between fluorescence emission peak wavelength and nanocrstal size. While the XRD approach may be more accurate, the emission peak approach can also be reliable and can be more convenient.
- Example techniques have been described in X. Michalet et a/., "Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics," Science, vol. 307, pp. 538-541, 2005, the contents of which are incorporated herein by reference.
- the molar ratio of Cd:Te in the core can vary from about 2.5:1 to about 3.5:1. This ratio may vary with core size. For example, when the core has a diameter of about 4 nm, the ratio is about 3.3:1.
- Quantum dot 10 has a fluorescence quantum yield higher than about 16%, such as up to about 45%.
- the quantum yield of QD 10 may be from about 20% to about 25% with an emission peak wavelength in the range of about 520 to about 620 nm, such as when it is formed with NaHTe as the Te precursor.
- the quantum yield of QD 10 may also be from about 30% to about 45% with an emission peak wavelength in the range of from about 500, or about 520 nm, to about 620 nm, such as when it is formed with H 2 Te as the Te precursor.
- quantum yield is the number of photons emitted per absorbed photon. Quantum yield may be measured using any suitable technique. Suitable techniques are known to persons skilled in the art. For example, fluorescein is conventionally used as the reference standard.
- the peak bandwidth is from about 30 nm to about 52 nm. As can be appreciated, the peak bandwidth refers to the Full Width at Half Maximum (FWHM) around the peak.
- quantum dots 10 can be formed from a solution, which includes a telluride (Te) precursor, a cadmium (Cd) precursor, and glutathione (GSH).
- Te and Cd precursors are provided in the solution for forming CdTe nanocrystals, and the GSH is introduced to the solution for forming shells covering the nanocrystals.
- the solution may be aqueous, i.e., having water as a solvent.
- the solution may be heated to accelerate the growth of the nanocrystals, as will be further discussed below.
- the molar ratio of Cd, Te, and GSH in the solution can vary.
- the molar ratio of Cd:Te may vary from about 3:1 to about 7:1
- the molar ratio of Te.GSH may vary from about 1 :2 to about 1:10.
- the molar ratios can affect the properties of the resulting QDs and the time required to form the QDs. It can be advantageous if the molar ratio is about 5:1 :5 (Cd:Te:GSH), as the resulting QDs can have relatively high quantum yield.
- the Te precursor and Cd precursor can be any suitable chemical compounds for reacting with each other to form cores 12.
- the Te precursor can include sodium hydrotelluride (NaHTe) or hydrogen telluride (H 2 Te), or a combination of both. It can be advantageous to use H 2 Te as the Te precursor as the resulting QDs can have a better quality, such as higher quantum yield, than QDs synthesized with NaHTe as the Te precursor.
- the Cd precursor can include a water-soluble Cd salt such as cadmium chloride (CdCI 2 ), cadmium perchloride, cadmium acetate, and the like, or any combination thereof.
- the solution has a pH value above about 11.0. It can be advantageous to have a pH value from about 11.2 to about 11.8, such as about 11.5.
- the solution may be prepared by mixing two precursor solutions each respectively containing one or the other of the two precursors.
- the solution may be prepared by mixing a Cd precursor solution and a Te precursor solution.
- One of the precursor solutions may also contain GSH, so as to introduce GSH to the resulting solution.
- the precursor solutions may be mixed by "one-shot” mixing.
- Other mixing techniques such as drop-wise mixing, may also be used.
- it may be advantageous to apply the "one-shot” mixing technique as it can result in improved results such as higher quantum yields and narrower bandwidths. It has been found that "one-shot” mixing can result in narrower initial particle size distribution than drop-wise mixing. As can be appreciated, narrow size distribution of the nanocrystals can be advantageous.
- mixing of the precursors can also be carried out by bubbling a gas comprising a precursor, such as H 2 Te as the Te precursor, through a solution comprising another precursor, such as a Cd precursor. It may be advantageous to prepare the mixture of the precursors in this manner, as will become apparent below.
- CdTe nanocrystals can form and grow by self- assembly in the solution upon mixing of the precursors at an appropriate temperature.
- a glutathione shell can form immediately after a CdTe nanocrystal core is formed, by binding to the surface of newly-formed nanocrystal.
- the shell comprises a monolayer of glutathione, which has a thickness of about 0.5 nm.
- the core can further grow because Cd and Te ions can penetrate or permeate through the shell.
- the nanocrystals will continue to grow under suitable conditions, which can be understood by persons skilled in the art. For example, within a limit, at higher temperatures the nanocrystals will grow faster.
- the sizes of the QDs formed can be controlled, or, in other words, the fluorescence emission peak can be tuned.
- the solution can be heated at a suitable temperature for a selected period of time.
- a suitable temperature for a selected period of time.
- an aqueous solution containing a mixture of the Cd precursor solution and Te precursor solution can be heated to about 95°C for up to about 90 minutes to form QDs.
- the heating temperature can vary and can be readily determined in a particular application by persons skilled in the art. For example, the heating temperature will be limited by the boiling temperature of the solution. For an aqueous solution, the heating temperature should be below about 100 0 C at normal conditions.
- the heating time can be selected to control the resulting sizes of the formed quantum dots. In some embodiments, a heating time of less than about 90 minutes may be appropriate. The particular heating time in any particular application can be assessed depending on various factors such as the heating temperature, the contents of the solution, the desired sizes of the final QDs, and the like.
- the heating time may be selected to limit growth of the nanocrystals such that the resulting quantum dots have core diameters (diameters of the cores) from about 2.8 nm to about 5 nm.
- the heating time may also be selected so that the core diameters have an average diameter of about 4 nm.
- the external diameters of the formed quantum dots may vary from about 4 to about 6 nm, depending on the heating time.
- the heating time can also be selected to limit growth of the nanocrystals so that a formed quantum dot has a selected fluorescence emission spectrum, which is dependent on the size of the quantum dot.
- their fluorescence spectra may peak at different wavelengths ranging from about 500 to about 620 nm, as will be illustrated in the following example.
- the solution can be rapidly cooled to prevent significant further growth of the nanoparticles, thus forming quantum dots 10 with desired sizes, or with sizes in a selected range. Cooling can be carried out in any suitable manner. For example, the solution can be cooled by being immersed in an ice bath. Rapid cooling can be advantageous for obtaining QDs with desired fluorescence emission characteristics. For instance, the sizes of the formed QDs can vary only within a narrow range when the solution is cooled rapidly. However, when it is not necessary to have a narrow size distribution, the solution may be cooled slowly.
- Sample QDs were prepared with the following example procedure, where all reactions were carried out in oxygen-free water under an argon gas environment.
- Step 1 A Te precursor was prepared, according to one of two protocols.
- Protocol One a precursor solution containing sodium hydrotelluride (NaHTe) was prepared by reacting sodium borohydride (NaBH 4 ) with tellurium powder (Te) in water.
- NaBH 4 sodium borohydride
- Te tellurium powder
- the Te powders were of 99.8% stated purity and 200 mesh.
- the NaBH 4 was slightly excessive.
- Protocol Two an H 2 Te gas was prepared by reacting aluminum telluride (AI 2 Te 3 ) with 0.5 M sulphuric acid (H 2 SO 4 ).
- Step 2 A precursor solution containing CdCI 2 and glutathione (GSH) with a pH of about 11.5 was prepared.
- Step 3 A mixture solution was prepared. According to Protocol One, the two precursor solutions from Steps 1 and 2 were mixed by "one-shot” mixing. According to Protocol Two, the H 2 Te gas from Step 1 was bubbled through the precursor solution from Step 2, for a few minutes. In either case, the mixture solution was vigorously stirred. The mixture solution had a total volume of 300 ml. The respective molar contents of Cd, Te, and GSH in the mixture solution were 3, 0.6, and 3 mmol.
- Step 4 The mixture solution was heated at a temperature of about 95°C for various time periods. It took about two minutes to heat the solution from room temperature to 95 0 C. GSH-capped CdTe QDs grow quickly upon reaching the temperature of about 95°C.
- Step 5 After the selected heating time, the heated solution was immersed in an ice bath to stop further growth of QDs. For different samples, heating was stopped after different lengths of time to obtain QDs of different particle sizes and fluorescence emission spectra.
- Step 6 The prepared QDs were precipitated and washed several times in 2-propanol, forming pellets of QDs. Excess salt, such as NaCI, NaOH and excess GSH, was removed by washing.
- Step 7 The pellets were dried at room temperature in vacuum overnight, forming powders of sample QDs.
- FIG. 3 shows measured dependence of emission peak wavelength on heating time. As can be seen, the peak wavelength increases from about 520 nm to about 620 nm as heating time increases from about 10 minutes to about 120 minutes. As can also be seen, the peak shifts little after about 90 minutes of heating.
- the quantum yields and bandwidths of sample QDs were also measured. Some results are shown in FIG. 4.
- the quantum yield was determined by measuring the integrated fluorescence intensities of the sample QDs and a reference solution which was a fluorescein solution in basic ethanol and had a quantum yield of 0.97. For these measurements, the QD samples were diluted to yield absorption of 0.1 at 470 nm. As can be seen, the quantum yields varied from about 10% to about 45%, and the bandwidth varied from about 30 nm to about 52 nm. The maximum quantum yield measured is about 45% at about 600 nm. The quantum yield is above 16% over a broad spectral range, from about 500 to about 625 nm.
- the quantum yield is between about 30% to about 45% over the range of about 510 nm to about 620 nm. These values are much higher than CdTe QDs capped by other thiol ligands, which typically exhibit quantum yields in the range of 1 to 10%.
- the glutathione shell stabilizes the geometry of the CdTe nanocrystal core, thus leading to increased quantum yield.
- QDs may have surface defects which can dramatically affect their quantum yield.
- the geometry of surface atoms will change as the nanocrystals change their size.
- the surface geometry may be optimal for, for example, the GSH-Cd interaction.
- the core size is too large or too small, there can be geometry mismatch between the stabilizing agent and the surface core atom such as Cd atoms. The mismatch can result in an unsmooth, defected surface, thus a reduced quantum yield.
- sample QDs were measured with Dynamic light scattering (DLS) technique in an aqueous solution.
- the sample QD powder was dissolved in deionized water with a final concentration up to 300 mg/ml.
- the measurements were performed on a BI-200SMTM laser light scattering system, provided by Brookhaven Instruments CorporationTM.
- the measured external diameters of the sample QDs vary from about 3.8 nm to about 6 nm.
- FIG. 5 shows the measured results for sample QDs having a fluorescence emission peak at 600 nm and quantum yield of 26%.
- the external diameters of the QDs vary from about 4.3 nm to about 6 nm and the average external diameter is about 5 nm.
- the core diameters are from about 2.8 nm to about 5 nm, and the average core diameter is about 4 nm. Only about 1 v% (volume percent) of the QDs was aggregated to form clusters of the size of 10 to 20 nm.
- TEM images of the sample QDs were obtained with an FEI Tecnai TF-20TM field emission high-resolution TEM (200 kV).
- An example TEM image is shown in FIG. 6, which illustrates the crystallinity of the sample QDs.
- the inset at the top-right corner is a magnified image of the portion enclosed by the dotted line.
- X-ray diffraction (XRD) pattern of vacuum-dried sample QD powder was obtained with a PANalytical X'Pert PROTM Diffraction system. An example image is shown in FIG. 7.
- the sample QD powder exhibited an XRD peak at about 27° (002) and a broad band at about 47° due to overlap of (110), (103) and (112) diffractions. This confirms that the sample QDs have a zinc blende cubic crystal structure, like other thiol-capped CdTe QDs.
- the XRD pattern for CdS quantum dots is also shown, which are marked as "CdS".
- the sample QDs were subjected to elemental analysis with an ELAN 9000/DRCTM Inductively Coupled Plasma Mass Spectrometer (ICP-MS).
- ICP-MS Inductively Coupled Plasma Mass Spectrometer
- sample QDs with a fluorescence emission peak at 600 nm have a molecular weight of about 180,000 Dalton and a molar extinction coefficient at 470 nm of about 2 x 10 5 M "1 cm "1 .
- sample QDs were stable in either pellet form or in an aqueous solution for several months when stored in air at about 4°C in the dark.
- the fluorescence intensity of the sample QDs in solution depends on the pH value of the solution, as illustrated in FIG. 8.
- the round points are data points measured in a Tris-HCI buffer solution.
- the triangle points are data points measured in a phosphate buffer solution. As shown, the fluorescence intensity is roughly constant at pH above 9 and decreases at pH below 9. When pH value is below about 6, fluorescence is substantially quenched.
- sample QDs did not aggregate after 3 days of incubation in various saline buffer solutions and cell culture media. Thus, these QDs are very stable and are suitable for cell labeling and bioimaging applications. Since the concentration of free GSH in many cells can be as high as 1-10 mM, the interference from other thiol ligands will be low and thus long-term in vivo stability of the sample QDs should be very good.
- sample QDs have very low toxicity or interference with cell viability or function, showing that the sample QDs can be suitable for live cell imaging.
- the sample QDs were also labeled with biotin, such as NHS-biotin.
- biotin such as NHS-biotin.
- the biotin-labeled QDs were used to label actin on the skeleton of NIH3T3 cells through standard immunostaining procedures and were used successfully to image the NIH3T3 cells.
- the QD powders were re-dissolved in phosphate- buffered saline (PBS) buffer and incubated with N-hydroxysuccinimidobiotin (NHS- biotin) for two hours. Free NHS-biotin was removed by ultrafiltration.
- PBS phosphate- buffered saline
- FIGS. 9A and 9B show two exemplary images of NIH3T3 cells which were actin immunostained with biotin-labeled QDs.
- the image in FIG. 9A is a confocal fluorescence image and the image in FIG.
- 9B is a transmission image. Fluorescence images were taken with an Olympus Fluoview 300TM confocal laser scanning system with 488-nm argon laser excitation. QD emission at 600 nm was detected with two chroma 570-nm longpass optical filters.
- the QDs disclosed herein can have relatively small particle size and high quantum yield.
- the high quantum yield can be achieved without post-formation treatment.
- the QDs can also have high solubility in solutions of a wide range of pH.
- the QDs can exhibit high stability in cell culture.
- each GSH molecule has one amino group and two carboxyl groups, GSH molecules can be cross-linked to each other.
- the QDs disclosed herein can be bio- polymerized and stabilized with a matrix on a surface. They can also have high stability and low cytotoxicity.
- the QDs disclosed herein can be used in various applications, such as for bio-labeling.
- the QDs can be used as bio-tags for in vitro or in vivo bioimaging, and as fluorescent probes for detection of DNA or proteins.
- QDs can also be used in other fields such as in light-emitting devices, photonic and core-shell structures, optoelectronic and photovoltaic devices, optical amplifier media, and the like.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06700584A EP1868938A4 (en) | 2005-03-31 | 2006-01-11 | Cdte/gsh core-shell quantum dots |
AU2006229599A AU2006229599A1 (en) | 2005-03-31 | 2006-01-11 | CDTE/GSH core-shell quantum dots |
US11/910,305 US20080246006A1 (en) | 2005-03-31 | 2006-01-11 | Cdte/Gsh Core-Shell Quantum Dots |
JP2008503995A JP2008534424A (en) | 2005-03-31 | 2006-01-11 | CDTE / GSH core-shell quantum dots |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66673105P | 2005-03-31 | 2005-03-31 | |
US60/666,731 | 2005-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006104464A1 true WO2006104464A1 (en) | 2006-10-05 |
Family
ID=37053654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SG2006/000003 WO2006104464A1 (en) | 2005-03-31 | 2006-01-11 | Cdte/gsh core-shell quantum dots |
Country Status (5)
Country | Link |
---|---|
US (1) | US20080246006A1 (en) |
EP (1) | EP1868938A4 (en) |
JP (1) | JP2008534424A (en) |
AU (1) | AU2006229599A1 (en) |
WO (1) | WO2006104464A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008133598A1 (en) * | 2007-04-30 | 2008-11-06 | Agency For Science, Technology And Research | Forming crosslinked-glutathione on nanostructure |
WO2009028390A1 (en) * | 2007-08-29 | 2009-03-05 | Konica Minolta Medical & Graphic, Inc. | Semiconductor nanoparticle phosphor aggregate, process for producing the aggregate, and method for observing single molecule using the aggregate |
WO2012090161A1 (en) | 2010-12-28 | 2012-07-05 | Universidad De Santiago De Chile | Synthesis of highly fluorescent gsh-cdte nanoparticles (quantum dots) |
WO2016182973A1 (en) * | 2015-05-08 | 2016-11-17 | Massachusetts Institute Of Technology | One-pot method for preparing core-shell nanocrystals |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090220792A1 (en) * | 2006-01-20 | 2009-09-03 | Singapore Agency For Science, Tech And Research | Synthesis of Alloyed Nanocrystals in Aqueous or Water-Soluble Solvents |
KR101207400B1 (en) | 2010-12-29 | 2012-12-04 | 재단법인대구경북과학기술원 | Method for Manufacturing CdTe nanoparticles by sonochemical method |
ES2695226T3 (en) | 2014-08-13 | 2019-01-02 | Univ Koc | Silver chalcogenide quantum dots that emit in the near IR |
CN112577958B (en) * | 2019-09-29 | 2023-06-27 | 成都辰显光电有限公司 | Quantum dot detection device and method |
CN112760096B (en) * | 2021-01-11 | 2022-08-12 | 浙江工业大学 | Design method and application of fluorescent quenching array sensor based on cadmium telluride quantum dots |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6682596B2 (en) * | 2000-12-28 | 2004-01-27 | Quantum Dot Corporation | Flow synthesis of quantum dot nanocrystals |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3835135B2 (en) * | 2000-07-27 | 2006-10-18 | 三菱化学株式会社 | Semiconductor ultrafine particles formed by bonding amino groups |
US6649138B2 (en) * | 2000-10-13 | 2003-11-18 | Quantum Dot Corporation | Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media |
GB0026382D0 (en) * | 2000-10-27 | 2000-12-13 | Nanox Ltd | Production of metal chalcogenide nanoparticles |
US7153703B2 (en) * | 2001-05-14 | 2006-12-26 | Board Of Trustees Of The University Of Arkansas N. A. | Synthesis of stable colloidal nanocrystals using organic dendrons |
WO2003092043A2 (en) * | 2001-07-20 | 2003-11-06 | Quantum Dot Corporation | Luminescent nanoparticles and methods for their preparation |
CA2459110A1 (en) * | 2001-08-31 | 2003-03-06 | Cynthia C. Bamdad | Affinity tag modified particles |
CA2480518C (en) * | 2002-03-29 | 2016-07-19 | Massachusetts Institute Of Technology | Light emitting device including semiconductor nanocrystals |
IL165033A0 (en) * | 2002-05-07 | 2005-12-18 | Univ California | Bioactivation of particles |
EP1541656A4 (en) * | 2002-06-19 | 2007-11-14 | Nat Inst Of Advanced Ind Scien | Semiconductor superfine particle phosphor and light emitting device |
-
2006
- 2006-01-11 US US11/910,305 patent/US20080246006A1/en not_active Abandoned
- 2006-01-11 AU AU2006229599A patent/AU2006229599A1/en not_active Abandoned
- 2006-01-11 EP EP06700584A patent/EP1868938A4/en not_active Withdrawn
- 2006-01-11 JP JP2008503995A patent/JP2008534424A/en active Pending
- 2006-01-11 WO PCT/SG2006/000003 patent/WO2006104464A1/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6682596B2 (en) * | 2000-12-28 | 2004-01-27 | Quantum Dot Corporation | Flow synthesis of quantum dot nanocrystals |
Non-Patent Citations (3)
Title |
---|
KORSOUNSKI V. ET AL.: "Investigation of nanocrystalline CdS-glutathione particles by radial distribution function", J. APPL. CRYST., vol. 36, 2003, pages 1389 - 1396, XP002556384 * |
See also references of EP1868938A4 * |
TORRES-MARTINEZ C. ET AL.: "Biomoleculary capped uniformly sized nanocrystalline materials: glutathione-capped ZnS nanocrystals", NANOTECHNOLOGY, vol. 10, 1999, pages 340 - 354, XP008120547 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008133598A1 (en) * | 2007-04-30 | 2008-11-06 | Agency For Science, Technology And Research | Forming crosslinked-glutathione on nanostructure |
WO2009028390A1 (en) * | 2007-08-29 | 2009-03-05 | Konica Minolta Medical & Graphic, Inc. | Semiconductor nanoparticle phosphor aggregate, process for producing the aggregate, and method for observing single molecule using the aggregate |
WO2012090161A1 (en) | 2010-12-28 | 2012-07-05 | Universidad De Santiago De Chile | Synthesis of highly fluorescent gsh-cdte nanoparticles (quantum dots) |
US9732272B2 (en) | 2010-12-28 | 2017-08-15 | Universidad De Santiago De Chile | Synthesis of highly fluorescent GSH-CDTE nanoparticles (quantum dots) |
WO2016182973A1 (en) * | 2015-05-08 | 2016-11-17 | Massachusetts Institute Of Technology | One-pot method for preparing core-shell nanocrystals |
US10246637B2 (en) | 2015-05-08 | 2019-04-02 | Massachusetts Institute Of Technology | One-pot method for preparing core-shell nanocrystals |
Also Published As
Publication number | Publication date |
---|---|
JP2008534424A (en) | 2008-08-28 |
AU2006229599A1 (en) | 2006-10-05 |
EP1868938A1 (en) | 2007-12-26 |
EP1868938A4 (en) | 2010-01-06 |
US20080246006A1 (en) | 2008-10-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20080246006A1 (en) | Cdte/Gsh Core-Shell Quantum Dots | |
JP5907544B2 (en) | Method for producing nanoparticles | |
KR102180604B1 (en) | Cadmium-free Quantum Dot Nanoparticles | |
US20100316797A1 (en) | Forming glutathione-capped and metal-doped zinc selenide/zinc sulfide core-shell quantum dots in aqueous solution | |
US9546317B2 (en) | Synthesis of water soluble non-toxic nanocrystalline quantum dots and uses thereof | |
Zeng et al. | Aqueous synthesis of type-II CdTe/CdSe core–shell quantum dots for fluorescent probe labeling tumor cells | |
US20090220792A1 (en) | Synthesis of Alloyed Nanocrystals in Aqueous or Water-Soluble Solvents | |
JP2005522534A (en) | Luminescent material comprising nanocrystals having core / shell structure, and method for preparing the same | |
JP4714859B2 (en) | Method for synthesizing copper sulfide nanoparticles | |
Lesnyak et al. | One-pot aqueous synthesis of high quality near infrared emitting Cd 1− x Hg x Te nanocrystals | |
Wu et al. | A dual-colored bio-marker made of doped ZnO nanocrystals | |
Chen et al. | A one-step aqueous synthetic route to extremely small CdSe nanoparticles | |
Shen et al. | Large scale synthesis of stable tricolor Zn 1− x Cd x Se core/multishell nanocrystals via a facile phosphine-free colloidal method | |
Meadows et al. | Template-directed synthesis of silica-coated J-aggregate nanotapes | |
Liu et al. | One-pot synthesis of CdSe magic-sized nanocrystals using selenium dioxide as the selenium source compound | |
Wu et al. | Depositing ZnS shell around ZnSe core nanocrystals in aqueous media via direct thermal treatment | |
JP2022527219A (en) | Nanocrystals | |
Su et al. | Microwave synthesis of nearly monodisperse core/multishell quantum dots with cell imaging applications | |
Zhang et al. | One-pot synthesis of stable water soluble Mn: ZnSe/ZnS core/shell quantum dots | |
Khanna et al. | One-pot synthesis of oleic acid-capped cadmium chalcogenides (CdE: E= Se, Te) nano-crystals | |
Thirugnanam et al. | Synthesis, structural, optical and morphological properties of CdSe: Zn/CdS core–shell nanoparticles | |
Yang et al. | Photoluminescent Enhancement of CdSe/Cd1− x Zn x S Quantum Dots by Hexadecylamine at Room Temperature | |
Yang et al. | Near-infrared emitting CdTe 0.5 Se 0.5/Cd 0.5 Zn 0.5 S quantum dots: synthesis and bright luminescence | |
Zeto et al. | General strategy for doping rare earth metals into Au–ZnO core–shell nanospheres | |
CN109735323B (en) | Preparation method of quantum dot luminescent compound |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2008503995 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006229599 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006700584 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: RU |
|
ENP | Entry into the national phase |
Ref document number: 2006229599 Country of ref document: AU Date of ref document: 20060111 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 2006229599 Country of ref document: AU |
|
WWP | Wipo information: published in national office |
Ref document number: 2006700584 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 11910305 Country of ref document: US |