WO2006103045A1 - Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses - Google Patents

Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses Download PDF

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Publication number
WO2006103045A1
WO2006103045A1 PCT/EP2006/002806 EP2006002806W WO2006103045A1 WO 2006103045 A1 WO2006103045 A1 WO 2006103045A1 EP 2006002806 W EP2006002806 W EP 2006002806W WO 2006103045 A1 WO2006103045 A1 WO 2006103045A1
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Prior art keywords
methyl
phenyl
oxazol
alkyl
methylpyrrolidin
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PCT/EP2006/002806
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French (fr)
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WO2006103045B1 (en
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Sylvain Celanire
Frédéric DENONNE
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Ucb Pharma S.A.
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Priority to JP2008503418A priority Critical patent/JP2008534542A/en
Priority to EP06723777A priority patent/EP1866293A1/en
Priority to AU2006228690A priority patent/AU2006228690A1/en
Priority to CA002602336A priority patent/CA2602336A1/en
Priority to US11/910,191 priority patent/US7790720B2/en
Publication of WO2006103045A1 publication Critical patent/WO2006103045A1/en
Publication of WO2006103045B1 publication Critical patent/WO2006103045B1/en

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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Definitions

  • the present invention relates to compounds comprising an oxazole or thiazole moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as pharmaceuticals.
  • histamine H3 receptor has been known for several years and identified pharmacologically in 1983 by Arrang, J.M. et al. (Nature 1983, 302, 832). Since the cloning of the human histamine H3 receptor in 1999, histamine H3 receptors have been successively cloned by sequence homology from a variety of species, including rat, guinea pig, mouse and monkey.
  • Histamine H3 -receptor agonists, antagonists and inverse agonists have shown potential therapeutic applications as described in the literature, for example by Stark, H.
  • histamine H3 receptor is predominantly expressed in the mammalian central nervous system but can also be found in the autonomic nervous system. Evidence has been shown that the histamine H3 receptor displays high constitutive activity, which activity occurs in the absence of endogenous histamine or of a H3 -receptor agonist. Thus, a histamine H3 -receptor antagonist and/or inverse agonist could inhibit this activity.
  • the general pharmacology of histamine H3 -receptor, including H3 -receptor subtypes, has been reviewed by Hancock, A.A (Life Sci. 2003, 73, 3043).
  • the histamine H3 -receptor is not only considered as a presynaptic autoreceptor on histaminergic neurons, but also as a heteroreceptor on non-histaminergic neurons (Barnes, W. et al., Eur. J. Pharmacol. 2001, 431, 215). Indeed, the histamine H3-receptor has been shown to regulate the release of histamine but also of other important neurotransmitters, including acetylcholine, dopamine, serotonin, norepinephrin and ⁇ -aminobutyric acid (GABA).
  • GABA ⁇ -aminobutyric acid
  • histamine H3 receptor is of current interest for the development of new therapeutics and the literature suggests that novel histamine H3 -receptor antagonists or inverse agonists may be useful for the treatment and prevention of diseases or pathological conditions of the central nervous system including as Mild Cognitive Impairment (MCI), Alzheimer's disease, learning and memory disorders, cognitive disorders, attention deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), Parkinson's disease, schizophrenia, dementia, depression, epilepsy, seizures or convulsions, sleep/wake disorders, narcolepsy, and/or obesity.
  • MCI Mild Cognitive Impairment
  • AD attention deficit disorder
  • ADHD attention-deficit hyperactivity disorder
  • Parkinson's disease schizophrenia, dementia, depression, epilepsy, seizures or convulsions, sleep/wake disorders, narcolepsy, and/or obesity.
  • H3 -receptor ligands alone or in combination with an acetylcholinesterase inhibitor may also be useful in the treatment of cholinergic-deflcit disorders, Mild Cognitive Impairment and Alzheimer's disease as reported by Morisset, S. et al. in Eur. J. Pharmacol.
  • H3 -receptor ligands alone or in combination with a histamine H ⁇ -receptor antagonist may be useful for the treatment of upper airway allergic disorders, as reported by
  • H3-receptor ligands alone or in combination with a muscarinic receptor ligands and particularly with a muscarinic M2 ⁇ receptor antagonist, may be useful for the treatment of cognitive disorders
  • Alzheimer's disease attention-deficit hyperactivity disorder.
  • H3 -receptor ligands may also be useful in the treatment of sleep/wake and arousal/vigilance disorders such as hypersomnia, and narcolepsy according to Passani,
  • H3 -receptor ligands and particularly H3-receptor antagonists or inverse agonists may be useful in the treatment of all type of cognitive-related disorders as reviewed by Hancock, A.A and Fox, G.B. in Expert Opin, Invest. Drugs 2004, 13, 1237
  • histamine H3 -receptor antagonists or inverse agonists may be useful in the treatment of cognitive dysfunctions in diseases such as mild cognitive impairment, dementia, Alzheimer's disease, Parkinson's disease, Down's syndrome as well as in the treatment of attention-deficit hyperactivity disorder (ADHD) as non-psychostimulant agents (see for example Witkin, J.M. et al., Pharmacol. Ther. 2004, 103(1), 1-20.
  • ADHD attention-deficit hyperactivity disorder
  • H3 -receptor antagonists or inverse agonists may also be useful in the treatment of psychotic disorders such as schizophrenia, migraine, eating disorders such as obesity, inflammation, pain, anxiety, stress, depression and cardiovascular disorders, in particular acute myocardial infarction.
  • United States patent US 6,436,939B2 relates to H3-receptor antagonists comprising benzoxazole or benzothiazole moieties.
  • a 1 is CH, C(alkyl), C-halogen or N;
  • RMs hydrogen, halogen, C ⁇ . ⁇ alkyl or alkoxy
  • R.3 is hydrogen, halogen, C ⁇ . ⁇ alkyl or alkoxy
  • R4 is hydrogen, halogen, C ⁇ . ⁇ alkyl, alkoxy or -O-L;
  • R.5 is hydrogen or -O-L;
  • L is C 1-6 -alkyl amino;
  • RIO is hydrogen, sulfonyl, amino, C ⁇ . ⁇ alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aryl, heteroaryl, C3_g cycloalkyl, 3-8 membered heterocycloalkyl, acyl, C 1-6 -alkyl aryl, C 1-6 - alkyl heteroaryl, C 2-6 -alkenyl aryl, C 2-6 ⁇ a lkenyl heteroaryl, C 2-6 alkynyl aryl, C2.6 alkynyl heteroaryl, Ci_ ⁇ 5-alkyl cycloalkyl, C 1-6 -alkyl heterocycloalkyl, C 2-6 -alkenyl cycloalkyl, C 2-6 -alkenyl heterocycloalkyl, C 2-6 -alkynyl cycloalkyl, C 2-6 ⁇ alkynyl heterocycloalkyl, alkoxy
  • RH is hydrogen, sulfonyl, amino, C ⁇ . ⁇ alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, aiyl, heteroaryl, C3_g cycloalkyl, 3-8 membered heterocycloalkyl, acyl, Ci_ ⁇ -alkyl aryl, C ⁇ . ⁇ - alkyl heteroaryl, C 2-6 -alkenyl aryl, C 2-6 -alkenyl heteroaryl, C 2-6 alkynyl aryl, C 2-6 alkynyl heteroaryl, C 1-6 -alkyl cycloalkyl, C 1-6 -alkyl heterocycloalkyl, C 2-6 -alkenyl cycloalkyl, C 2-6 -alkenyl heterocycloalkyl, C 2-6 -a lkynyl cycloalkyl, C 2-6 -alkynyl heterocycloalkyl, alk
  • R4 is hydrogen, halogen, C 1-6 alkyl or alkoxy.
  • alkyl is a group which represents saturated, monovalent hydrocarbon radicals having straight (unbranched), branched or cyclic moieties, or combinations thereof and containing 1-10 carbon atoms, preferably 1-8 carbon atoms; more preferably alkyl groups have 1-6 carbon atoms, most preferably alkyl groups have 1-4 carbon atoms.
  • Preferred alkyl groups are methyl, ethyl, trifluoromethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 1,3-dimethylbutyl, 3-methylbutyl, n- hexyl, 2-methoxy-l-methylethyl and l-(hydroxymethyl)-3-methylbutyl.
  • C ⁇ _ ⁇ alkyl refers to alkyl groups as defined here above having 1 to 6 carbon atoms. This term is exemplified by groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-hexyl, 1,3-dimethylbutyl, 3- methylbutyl and the like.
  • C 2-6 alkenyl refers to alkenyl groups preferably having from 2 to 6 carbon atoms and having at least 1 or 2 sites of alkenyl unsaturation.
  • C 2-6 -alkynyl refers to alkynyl groups preferably having from 2 to 6 carbon atoms and having at least 1 to 2 sites of alkynyl unsaturation.
  • C3_3 cycloalkyl is a monovalent group of 3 to 8 carbon atoms usually 3 to 6 carbon atoms derived from an unsaturated or saturated monocyclic or bicyclic hydrocarbon. Preferred cycloalkyl are cyclopropyl, cyclopentyl, 3,4- dimethylcyclopentyl and cyclohexyl.
  • C 1-6 -alkyl cycloalkyl refers to a C 1-6 alkyl having a cycloalkyl substituted. Examples include cyclopropylmethyl and the like.
  • C 2-6 a ⁇ enyl cycloalkyl, as used herein, refers to a C 2-6 alkenyl having a cycloalkyl substitutent.
  • C 2-6 -alkynyl cycloalkyl refers to a C 2-6 alkynyl having a cycloalkyl substitutent.
  • heteroatom as used herein represents a nitrogen, oxygen or sulfur atom.
  • halogen as used herein, represents an atom of fluorine, chlorine, bromine, or iodine.
  • heterocycloalkyl refers to a C3-8 cycloalkyl group according to the definition here above, in which 1 to 3 carbon atoms are replaced by heteroatoms chosen from the group consisting of O, S, N.
  • Each carbon of the heterocycloalkyl may be unsubstituted or substituted by one or more C 1.4 alkyl, C3-8 -cycloalkyl, C 1-6 -alkyl aryl or halogen as defined herein.
  • heterocycloalkyls are pyrrolidine, piperidine, piperazine, morpholine, 2- methylpyrrolidine, (2S)-2-methylpyrrolidine, (2R)-2-methylpyrrolidine, 4-methylpyridine, 2-methylpiperidine, 2,6-dimethylpiperidine, 4-methylpiperidine, 4-benzylpiperidine, 4- isopropylpiperazine, 3,5-dimethylpiperidine, 2-isobutylpyrrolidine, 4,4-difluoropiperidine, 2-ethylpyrrolidine, 4-cyclopentylpiperazine, 4-(2-pyrrolidin-l-ylethyl)piperazine, azepane,
  • heterocycloalkyl may also be fused with a C3_g cycloalkyl to form a bicyclic heterocycloalkyl. Examples include (4aR,8aS)-decahydroisoquinoline and the like.
  • heterocycloalkyl may be replaced by a carbonyl and/or substituted by an amino group or a heterocycloalkyl or C ⁇ _g alkyl heterocycloalkyl as defined herein.
  • heterocycloalkyl examples include 2-oxopyrrolidine, 2-oxopiperidine, (5S)-2-oxo-5-(pyrrolidin- 1 -ylmethyl)pyrrolidine, 3-(dimethylamino)pyrrolidhie, (2S)-2- (pyrrolidin-l-ylmethyl)pyrrolidine, 2-(pyrrolidin-l-ylmethyl)pyrrolidine and (2S)-2-
  • C 1-6 -alkyl heterocycloalkyl refers to a C 1-6 alkyl having a heterocycloalkyl as defined hereabove as substitutent.
  • C 2-6 -alkenyl heterocycloalkyl refers to a Co. ⁇ alkenyl having a heterocycloalkyl as defined here above as substitutent.
  • C 2-6 -alkynyl heterocycloalkyl refers to a C 2-6 alkynyl having a heterocycloalkyl as defined here above as substitutent.
  • amino group represents a group of formula - NR ⁇ R C wherein R ⁇ and R c are independently hydrogen, "C 1-6 alkyl", “C 2-6 alkenyl”, “C 2-6 alkynyl”, “C 3 _ 8 cycloalkyl", “heterocycloalkyl", “aryl”, “heteroaryl”, “C 1-6 -alkyl aryl”, “C 1-6 -alkyl heteroaryl”, “C 2-6 -alkenyl aryl”, “C 2-6 -alkenyl heteroaryl", “C 2-6 -alkynyl aryl", “C 2-6 -alkynylheteroaryl", “C 1 _6-alkyl cycloalkyl” or “C 1 _6-alkyl heterocycloalkyl” groups; or R ⁇ and R c are linked together with N to form a 3 to 8 membered heterocycloalkyl ring.
  • amnio groups are hexyl(methyl)amino, benzyl(methyl)amino, (2- methoxy-l-methylethyl)amino, [l-(hydroxymethyl)-3-methylbutyl]amino, cyclopentylamino, (l,3-dimethylbutyl)amino, (cyclopropylmethyl)(propyl)amino, (2- furylmethyl)(methyl)amino, sec-butyl(propyl)amino, benzylamino, (4aR, 8aS)- octahydroisoquinolin-2-(lH)-yl, (4-chlorobenzyl)amino, (3-methoxyphenyl)amino, (2S)-2- (morpholin-4-ylmethyl)pyrrolidiii- 1 -yl, (2-methyl-2H-tetrazol-5-yl)amino, anilino, (
  • RbR C wherein R ⁇ and R c are as defined here above for the amino group.
  • R ⁇ and R c together do not form a guanidine group.
  • Preferred aminocarbonyl groups include [(cyclopropylmethyl)(propyl)amino]carbonyl, (cyclopentylamino)carbonyl, (benzylamino)carbonyl, [(4-fluoro)benzylaminocarbonyl, [(4- fluoro)phenyl)amino] carbonyl, pyrrolidin- 1 -ylcarbonyl, piperidin- 1 -ylcarbonyl, 4,4- difluoropiperidin- 1 -ylcarbonyl, (2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -ylcarbonyl, azepan-1 -ylcarbonyl are morpholin-4-ylcarbonyl and (4-cyclopentylpiperazin-l- yl
  • Cj. ⁇ alkyl aminocarbonyl refers to a C 1-6 alkyl susbtituted by an aminocarbonyl as defined hereabove.
  • a C ⁇ . ⁇ alkyl amino represents a C ⁇ _ ⁇ alkyl group substituted by an amino group as defined above.
  • Preferred C 1-6 alkyl amino groups include 2-pyrrolidin-l-ylethyl, pyrrolidin- lylmethyl, piperidin- 1-ylmethyl, azepan-1 -ylmethyl, (2- methylpyrrolidm- 1 -yl)methyl, (2-methylpiperidinl -yl)methyl, (2,6-dimethylpiperidin- 1 - ylmethyl), (4-methylpiperidin-l-yl)methyl, 4-benzylpiperidin- 1-ylmethyl, 4- isopropylpiperazin- 1 -ylmethyl, 3 ,5 -dimethylpiperidin- 1 -ylmethyl, 2-isobutylpyrrolidin- 1 - ylmethyl, (4-cyclopentylpiperazin-l-yl)methyl, (4,4-difluor
  • acylamino refers to a group of formula -NR ⁇ C(O)R C wherein R ⁇ and R c are as defined hereabove for the amino group.
  • C 1-6 -alkyl acylamino refers to a C ⁇ . ⁇ alkyl substituted by an acylamino as defined hereabove.
  • alkylene represents a group of formula -(CE ⁇ ) x - in which x is comprised between 1 and 10, preferably comprised between 2 and 8, more preferably comprised between 2 and 6.
  • methylene as used herein represents a group of formula -CH2-.
  • aryl refers to an unsaturated aromatic carbocyclic group of from 6 to 14 carbon atoms having a single ring (e.g., phenyl) or multiple condensed rings (e.g., naphthyl). Preferred aryl include phenyl, 4-fluorophenyl, 4-chlorophenyl, 3- methoxyphenyl, naphthyl, phenantrenyl and the like.
  • C 1-6 -alkyl aryl refers to a group of formula -R"-aryl in which R" is a C 1-6 alkyl.
  • Preferred "C 1-6 -alkyl aryl” are benzyl, 4-fluorobenzyl and A- chlorobenzyl.
  • C 2-6 -alkenyl aryl refers to a C 2-6 alkenyl having an aryl substitutent.
  • C 2-6 ⁇ alkynyl aryl refers to a C 2-6 alkynyl having an aryl substitutent.
  • heteroaryl represents an aryl group as defined here above wherein one or more of the carbon atoms have been replaced by a heteroatom as defined herein.
  • heteroaromatic groups include optionally substituted pyridyl, pyrrolyl, furyl, thienyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadia-zolyl, 1,2,5-oxadiazolyl, l,3,4-oxadiazolyl,l,3,4-triazinyl, 1,2,3-triazinyl, benzofuryl, [2,3-dihydro]benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, isobenzothieny
  • Preferred heteroaryls are 2H-tetrazolyl, furyl and pyridinyl.
  • C 1-6 -alkyl heteroaryl refers to a C ⁇ .5 alkyl having a heteroaryl substituent as defined hereabove. Examples include 2-furylmethyl, (2-methyl-lH-imidazol- lyl)methyl and (lH-l,2,4-triazol-l-yl)methyl.
  • C 2-6 - a lkenyl heteroaryl refers to a C 2-6 alkenyl having a heteroaryl substitutent.
  • C 2-6 -alkynyl heteroaryl refers to a C 2-6 alkynyl having a heteroaryl substitutent.
  • alkoxy represents a group of formula -OR a wherein R a is "Ci.6 alkyl", “C 2 -6 alkenyl”, “C 2-6 alkynyl”, “C 3 _ 8 cycloalkyl", “heterocycloalkyl", “aryl”, “heteroaryl”, “C ⁇ -alkyl aryl” or “Ci_ 6 -alkyl heteroaryl”, “C 2 _6-alkenyl aryl”, “C 2-6 -alkenyl heteroaryl”, “C 2-6 -alkynyl aryl”, “C 2-6 -alkynyl heteroaryl", “Ci.g-alkyl cycloalkyl” or "C 1-6 -alkyl heterocycloalkyl”.
  • Preferred alkoxy group is methoxy.
  • C 1-6 -alkyl alkoxy refers to a C 1-6 -alkyl substituted by an alkoxy as defined here above.
  • C 1-6 -alkyl carboxy refers to a C 1-6 -alkyl susbtituted by a carboxy group including 2-carboxyethyl and the like.
  • acyl refers to the group -C(O)R e wherein R e includes H, "C 1-6 alkyl", “C 2 _6 alkenyl”, “C 2 _6 alkynyl”, “C3_g cycloalkyl", “heterocycloalkyl", “aryl”, “heteroaryl”, “C ⁇ -alkyl aryl” or “Ci_ 6 -alkyl heteroaryl", “C 2 _6-alkenyl aryl”, “C 2-6 -alkenyl heteroaryl", “C 2-6 -alkynyl aryl”, “C 2-6 -alkynylheteroaryl", “C 1-6 -alkyl cycloalkyl” and “C 1-6 -alkyl heterocycloalkyl”.
  • C 1-6 _alkyl acyl refers to a C ⁇ . g alkyl having an acyl substituent as defined here above, including 2-acetylethyl and the like.
  • C3_8-cycloalkyl acyl refers to a C3_g alkyl having an acyl substituent as defined here above.
  • aryl acyl refers to an aryl group having an acyl substituent as defined here above.
  • heteroaryl acyl refers to a heteroaryl group having an acyl substituent as defined here above.
  • heterocycloalkyl acyl refers to a heterocycloalkyl group having an acyl substituent as defined here above.
  • acyloxy refers to the group -OC(O)Rf wherein R ⁇ includes H, "C 1-6 alkyl", “C 2 _ 6 alkenyl”, “C 2 _ 6 alkynyl”, “C 3 . 8 cycloalkyl", “heterocycloalkyl”, “heteroaryl”, “C 1-6 -alkyl aryl”, “Ci_ 6 -alkyl heteroaryl”, “C 2 -6-alkenyl aryl”, “C 2 _ 6 - alkenyl heteroaryl", “C 2 _6-alkynyl aryl”, “C 2 _6-alkynyl heteroaryl", “C 2 _g-alkyl cycloalkyl” or "C ⁇ _6-alkyl heterocycloalkyl”.
  • Ci. ⁇ -alkyl acyloxy refers to a C ⁇ _ ⁇ alkyl having an acyloxy as defined here above as substituent.
  • alkoxycarbonyl refers to the group -C(O)ORg wherein RS includes H,
  • C 1-6 alkyl C 2 . 6 alkenyl
  • C 2 . 6 alkynyl C 3 . 8 cycloalkyl
  • heterocycloalkyl aryl, “heteroaryl”, “Ci_ 6 -alkyl aryl” or "Ci.g-alkyl heteroaryl
  • C 2 _6-alkenyl aryl C 2 -6-alkenyl heteroaryl
  • C 2 _6-alkynyl aryl C 2 _6-alkynylheteroaryr
  • C 2 _6-alkyl cycloalkyl Preferred alkoxycarbonyl are methoxycarbonyl, ethoxycarbonyl and hydroxycarbonyl.
  • C 1-6 -alkyl alkoxycarbonyl refers to a refers to a C ⁇ alkyl having a alkoxycarbonyl as defined here above as substituent.
  • ureido refers to a group of formula -NR 1 C(O)NR ⁇ R 0 wherein R* is as defined hereabove for R ⁇ or R c , and R ⁇ and R c are as defined here above for the amino group.
  • C 1-6 -alkyl ureido refers to a C 1-6 alkyl substituted by a ureido as defined here above.
  • carbamate refers to a group of formula— NR ⁇ C(O)OR 0 whrein R ⁇ and R c are as defined here above for the amino group.
  • C 1-6 -alkyl carbamate refers to a C 1-6 -alkyl substituted by a carbamate as defined here above.
  • sulfonyl refers to group of formula "-SO 2 -Rh” wherein R n is selected from H, "aryl”, “heteroaryl”, u C ⁇ . ⁇ alkyl", “C ⁇ . ⁇ alkyl” substituted with halogens, e.g., an -SO 2 -CF 3 group, "C 2 _6 alkenyl”, “C 2 _6 alkynyl”, “C 3 _ 8 cycloalkyl", “heterocycloalkyl", “aryl”, “heteroaryl", “C 1-6 -alkyl aryl” or “C 1-6 -alkyl heteroaryl", “C 2 _ 6 -alkenyl aryl", “C 2 _g-alkenyl heteroaryl", “C 2 _6-alkynyl aryl", “C 2 .g alkynyl heteroaryl", “C 1-6 -alkyl cycloalkyl", “C
  • sulfinyl refers to group of formula "-S(O)-RJ" wherein RJ is selected from H, "aryl”, “heteroaryl”, “C 1-6 alkyl", “Q .5 alkyl” substituted with halogens, e.g., an -SO-CF3 group, "C 2 _ 6 alkenyl”, “C 2 _ 6 alkynyl", “C 3 . 8 cycloalkyl", “heterocycloalkyl", “aryl”, “heteroaryl”, “Ci_ 6 -alkyl aryl” or “Ci_ 6 -alkyl heteroaryl", "C 2 .
  • Ci_g-alkyl sulfonyl refers to C 1-6 -alkyl groups having a sulfonyl substituent, including 2-(methylsulfonyl)ethyl and the like.
  • C 1-6 -alkyl sulfinyl refers to Ci_5 ⁇ alkyl groups having a sulfinyl as defined here above as susbtituent, including 2-(methylsulfinyl)ethyl and the like.
  • C 1-6 -alkyl sulfanyl refers to Ci. ⁇ -alkyl groups having a sulfanyl as defined here above substituent.
  • sulfonylamino refers to a group of formula -NRt>so 2 -R c wherein R ⁇ and R c are as defined here above for the amino group.
  • C 1-6 -alkyl sulfonylamino refers to C 1-6 -alkyl groups having a sulfonylamino as defined here above as substituent.
  • aminosulfonyl refers to a group of formula -SO 2 -NR ⁇ R 0 wherein R ⁇ and R c are as defined here above for the amino group.
  • C 1-6 -alkyl aminosulfonyl refers to C 1-6 -alkyl groups having an aminosulfonyl as defined here above as substituent.
  • ester represents a group of formula -COOR e , in which R e is a Cj .4 alkyl.
  • carboxylic acid as used herein represents a group of formula -COOH.
  • the C 1-6 alkyl of L is not substituted by a hydroxy group.
  • R ⁇ is a C ⁇ _g alkyl, said alkyl is unsubstiruted.
  • R ⁇ is hydrogen and R ⁇ is- O-L.
  • the present invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • a 1 is CH, C(CH 3 ), C-halogen or N;
  • RI is hydrogen or halogen
  • a 3 is O or S
  • R 3 is hydrogen, halogen, C 1.4 alkyl or C 1.4 alkoxy
  • R 4 is hydrogen, halogen, C1.4 alkyl, C1.4 alkoxy or -O-(CH2) n -NR 12a R 12b ;
  • R 5 is hydrogen or -O-(CH2) m -NR 13a R 13b ;
  • Rl2a an d Rl2b ⁇ 6 linked together to form a C ⁇ .g alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl;
  • R ⁇ 3a and R ⁇ 3b are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C ⁇ j[ alkyl, an amino group or a C ⁇ . ⁇ alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Cj_g alkyl, C3.fi cycloalkyl or C 1-6 alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C3.6 alkylene;
  • R!5 is hydrogen or a C ⁇ .g alkyl
  • R!6 is aryl, heteroaryl, Cj.g alkyl, C 1-6 alkyl cycloalkyl, C3..6 cycloalkyl, C ⁇ . ⁇ alkyl aryl or CH2-heteroaryl; or R!5 and R ⁇ are linked together to form a C3_g alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by an C ⁇ _ 5 alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or a C3_g cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3_g cycloalkyl or a carbonyl and another methylene being optionally substituted
  • R!7 is hydrogen or a C ⁇ _ g alkyl
  • R!8 is Cj.g alkyl, C ⁇ . ⁇ alkyl aryl or C ⁇ . ⁇ alkyl cycloalkyl; or Rl ⁇ and R ⁇ are linked together to form a C ⁇ -Q alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C3.6 cycloalkyl; n and m are independently an integer comprised between 2 and 8; w and r are independentely an integer comprised between 0 and 4; t and z are independentely an integer equal to 0 or 1; with the proviso that R 4 is -O-(CH2) n -NR 12a R 12b , when R 5 is hydrogen and that
  • R 5 is -O-(CH2) m -NR 13a R 13b , when R 4 is hydrogen, halogen, C ⁇ 4 alkyl or Ci_4 alkoxy; with the proviso that when Rl 1 is an ester or a carboxylic acid, R 4 is hydrogen, halogen, C 1.4 alkyl or C ⁇ .4 alkoxy; with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0.
  • each CH 2 in -O-(CH 2 ) n -NR 12a R 12b or -0-(CH 2 ) J11 -NR 1 3a R 13b may be unsusbstituted or substituted by one or more C 1.4 alkyl.
  • a 1 is CH, C(CH 3 ), C-F or N.
  • a ⁇ is CH, C-F or N. Most preferably, A ⁇ is CH or C-F.
  • Al is CH.
  • a 3 is O or S. In a particular embodiment A 3 is O. hi another particular embodiment A 3 is S.
  • Rl is hydrogen or fluorine.
  • Rl is hydrogen
  • R 3 is hydrogen, halogen or C ⁇ _ 4 alkyl. Usually, in another embodiment, R 3 is hydrogen, fluorine, methyl or methoxy.
  • R 3 is hydrogen or fluorine or methyl. Most preferably, R 3 is hydrogen or methyl.
  • R.4 is hydrogen, halogen, C ⁇ .4 alkyl, C ⁇ réelle4 alkoxy, or - O-(CH2) n -NRl2aRl2b
  • R ⁇ is hydrogen, bromine, fluorine, chlorine, methyl, methoxy, trifluoromethyl or -O-(CH2) n -NRl2aRl2b ea ch CH2 in -O ⁇ (CH2) n -NRl2aRl2b being optionally substituted by one or two methyl.
  • R4 is hydrogen, chlorine, bromine, fluorine, methyl, methoxy or -O-(CH2) n -NRl2aRl2b
  • R ⁇ is hydrogen, chlorine, bromine, fluorine or methoxy.
  • R4 is hydrogen or fluorine.
  • -NR 12a R 12b is 1- ⁇ yrrolidinyl.
  • n is comprised between 2 and 4.
  • n is equal to 3.
  • R ⁇ is hydrogen or -O-(CH2) m -NRl3aRl3b
  • R 5 is hydrogen or -O-(CH2) m -NR 13a R 13b , each CH2 in -O- (CH2) m -NRl3aRl3b being optionally substituted by one or two methyl.
  • R 5 is hydrogen or -O-(CH2) m -NR 13a R 13b . More preferably, R 5 is -O- (CH 2 ) m -NR 13a R 13b .
  • -NRl 3a Rl 3b is selected from the group consisting of 1-piperidinyl, 1- pyrrolidinyl, 2-methylpyrrolidin-l-yl, (2S)-2-methylpyrrolidin-l-yl, (2R)-2- methylpyrrolidin-1-yl, 4-isopropylpiperazin-l-yi, 4-methylpiperidin-l-yl, 2- methylpiperidin- 1 -yl, 2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl, 4-cyclopentylpiperazin- 1 - yl, 3-(dimethylamino)pyrrolidin-l-yl, 4-(2-pyrrolidin-l-ylethyl)pipe
  • -NR* 3a Rl 3b is selected from the group consisting of 1- piperidinyl, 2-methylpyrrolidin-l-yl, (2S)-2-methylpyrrolidin-l-yl, (2R)-2- methylpyrrolidin-1-yl, 4-methylpiperidin-l-yl, 2-methylpiperidin-l-yl, 2-(pyrrolidin-l- ylmethyl)pyrrolidin-l-yl, (2S)-2-(pyrrolidin-l-ylmethyl)pyrrolidin-l-yl, 2- isobutylpyrrolidin-1-yl, 2-ethylpyrrolidin-l-yl, (4aR, 8aS)-octahydroisoquinolin-2-(lH)-yl, 1-azepanyl, and 2,6-dimethylpiperidin-l-yl.
  • -NRl 3a Rl 3b is 2-methylpyrrolidin-l-yl, (2S)-2- methylpyrrolidin-1-yl or (2R)-2-methylpyrrolidin-l-yl.
  • m is comprised between 2 and 5.
  • m is comprised between 2 and
  • RlO is methyl.
  • -NRl ⁇ R 16 [ s selected from the group consisting of 1-piperidinyl, 2- methylpyrrolidin-1-yl, 1-pyrrolidinyl, 1-azepanyl, 4-methylpiperidin-l-yl, 2- methylpiperidin- 1 -yl, (3 ,5-dimethyl)piperidin- 1 -yl, hexyl(methyl)amino, benzyl(methyl)amino, (2-methoxy-l-methylethyl)amino, 2-azaspiro[5.5]undec-2-yl, 7,8- dimethyl-lazaspiro[4.4]non-l-yl, 2-oxopyrrolidin-l-yl, anilino, 2-methyl-lH-imidazol-l-yl, lH-l,2,4-triazol-l-yl, [l-(hydroxymethyl)-3-methylbutyl]amino, cyclopentylamino,
  • -NRl ⁇ RI 6 j selected from the group consisting of 1-piperidinyl, 2-methylpyrrolidin-l-yl, 1-pyrrolidinyl, 1-azepanyl, 2-methylpiperidin-l-yl, (3,5- dimethyl)piperidin-l-yl, hexyl(methyl)amino, benzyl(methyl)amino, 2-azaspiro[5.5]undec- 2-yl, 7,8-dimethyl-lazaspiro[4.4]non-l-yl, 2-oxopyrrolidin-l-yl, anilino, 2-methyl-lH- imidazol- 1 -yl, IH-1 ,2,4-triazol- 1 -yl, [ 1 -(hydroxymethyl)-3 -methylbutyl]amino, cyclopentylamino, (l,3-dimethylbutyl)amino, (cyclopropylmethyl)(propy
  • -NR ⁇ R ⁇ is 1-piperidinyl.
  • w is an integer equal to 0, 1 or 2. In a particular embodiment w is equal to l.
  • t is an integer equal to 0. In another particular embodiment, t is an integer equal to 1.
  • R 1 1 is hydrogen, methyl, COOCH3, COOH, bromine or -(CH 2 ) r -
  • -NR 17 R 18 is 1-piperidinyl, 2-oxopyrrolidin-l-yl, (cyclopropylmethyl)(propyl)amino, cyclopentylamino, benzylamino, (4- cyclopentyl)piperazin-l-yl, 4-morpholinyl or 4,4-difluoropiperidin-l-yl.
  • -NR 17 R 18 is 4- morpholinyl or 4,4-difluoropiperidin- 1 -yl.
  • z is equal to 0 or 1. In a particular embodiment z is equal to 0. In another particular embodiment z is equal to 1.
  • r is an integer equal to 0, 1 or 2. In a particular embodiment r is an integer equal to 0.
  • Combinations of one or more of these preferred groups are especially preferred.
  • the present invention relates to compounds of formula
  • a 1 is CH, C(CH 3 ), C-halogen or N;
  • RI is hydrogen; R 2 is
  • a 3 is O or S
  • R 3 is hydrogen, halogen or C ⁇ .4 alkyl
  • R 4 is hydrogen, halogen, C1.4 alkyl, C1.4 alkoxy or -0-(CH 2 V-NR 12a R 12b R 5 is hydrogen or -O-(CH2) m -NR 13a R 13b ;
  • R* 2a and Rl 2b are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C ⁇ .4 alkyl;
  • Rl3a an( j Rl3b aj-g linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl, an amino group or an C 1-6 alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a C ⁇ _ 8 alkyl, C ⁇ - ⁇ cycloalkyl or C ⁇ . ⁇ alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C ⁇ - ⁇ alkylene;
  • R15 is hydrogen or a Cj.g alkyl
  • R!6 is aryl, heteroaryl, Cj.g alkyl, C ⁇ .g cycloalkyl, C 1-6 alkyl cycloalkyl, Cj.6 alkyl aryl or a CH2 ⁇ heteroaryl; or R.15 and R ⁇ are linked together to form a C ⁇ s alkylene, each methylene of the alkylene being optionally substituted by one or two C ⁇ .4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by an C 1-6 alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C3_ ⁇ cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3_g cycloalkyl or a carbonyl and another methylene being optionally substitute
  • R!7 is hydrogen or a Cj.g alkyl
  • R! 8 is Cj.g alkyl, C ⁇ _g alkyl cycloalkyl or a C ⁇ . ⁇ alkyl aryl; or R!7 and Rl8 are linked together to form a C3.5 alkylene, each methylene of the alkylene being optionally substituted by one or two C ⁇ .4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C ⁇ - ⁇ cycloalkyl; n and m are independently an integer comprised between 2 and 8; w and r are independentely an integer comprised between 0 and 4; t and z are independentely an integer equal to 0 or 1 ; with the proviso that R 4 is -O-(CH2) n -NRl 2a Rl 2b , when R 5 is hydrogen and that
  • R 5 is -O-(CH2) m -NRl 3a Rl 3b , when R 4 is hydrogen, halogen, trifluoromethyl, C1.4 alkyl or Ci_4 alkoxy; with the proviso that when Rl 1 is an ester or a carboxylic acid, R 4 is hydrogen, halogen, C ⁇ .4 alkyl or C 1.4 alkoxy. with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0.
  • the invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • a 1 is CH, C(CH 3 ), C-halogen or N;
  • R 1 is hydrogen or fluorine
  • R 2 is
  • a 3 is O or S
  • R 3 is hydrogen, fluorine, methyl or methoxy
  • R4 is hydrogen, bromine, fluorine, chlorine, methyl, methoxy, trifluoromethyl or - O-(CH 2 ) n -NR 12a R 12b , each CH 2 in -O-(CH2) n -NR 12a R 12b being optionally substituted by one or two methyl;
  • R 5 is hydrogen or -O-(CH2) m -NR 13a R 13b , each CH 2 in -O-(CH 2 ) m -NR 13a R 13b being optionally substituted by one or two methyl;
  • R 12a and R 12b are linked together to form a C 3 _6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl;
  • R 13a and R 13b are linked together to form a C 3 _g alkylene, each methylene of the alkylene being optionally substituted by one or two C ⁇ .4 alkyl, an amino group or C ⁇ . ⁇ alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl, a C 3 _6 cycloalkyl or C 1-6 alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C 3 _g alkylene;
  • R 1 5 is hydrogen or a Cj.g alkyl
  • R 1 ⁇ is aryl, heteroaryl, C ⁇ .g alkyl, C3.6 cycloalkyl, C 1-6 alkyl cycloalkyl, C ⁇ . ⁇ alkyl aryl or a CH 2 -heteroaryl
  • R 1 ⁇ and R 1 ⁇ are linked together to form a C 3 _g alkylene, each methylene of the alkylene being optionally substituted by one or two Cj .4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by Cj_6 alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C ⁇ .g alkyl or C- ⁇ - ⁇ cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3
  • the invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • a 1 is CH, C(CH 3 ), C-F or N;
  • RI is hydrogen; R 2 is
  • a 3 is O or S;
  • R 3 is hydrogen, fluorine or methyl;
  • R ⁇ is hydrogen, chlorine, bromine, fluorine, methyl, methoxy or -O-(CH2)n ⁇ NR 12a R 12b.
  • R 5 is hydrogen or -O-(CH2) m -NR 13a R 13b ;
  • R 12b is 1-pyrrolidinyl
  • Rl 3b is selected from the group consisting of 1-piperidinyl, 1-pyrrolidinyl, 2-methylpyrrolidin-l-yl, (2S)-2-methylpyrrolidin-l-yl, (2R)-2-methylpyrrolidin-l-yl, 4- isopropylpiperazin- 1 -yl, 4-methylpiperidin- 1 -yl, 2-methylpiperidin- 1 -yl, 2-(pyrrolidin- 1 - ylmethyl)pyrrolidin- 1 -yl, 4-cyclopentylpiperazin- 1 -yl, 3 -(dimethylamino)pyrrolidin- 1 -yl, 4-(2-pyrrolidin-l-ylethyl)piperazin-l-yl, 1-azepanyl, 2,6-dimethylpiperidin-l-yl, (2S)-2- (pyrrolidin-l-yhnethyl)pyrrolidin-l-yl, 2-(but
  • -NR15R16 is selected from the group consisting of 1-piperidinyl, 2- methylpyrrolidin-1-yl, 1-pyrrolidinyl, 1-azepanyl, 4-methylpiperidin-l-yl, 2- methylpiperidin- 1 -yl, (3,5 -dimethyl)piperidin- 1 -yl, hexyl(methyl)amino, benzyl(methyl)amino, (2-methoxy-l-methylethyl)amino, 2-azaspiro[5.5]undec-2-yl, 7,8- dimethyl- 1 azaspiro[4.4]non- 1 -yl, 2-oxopyrrolidin- 1 -yl, anilino, 2-methyl- 1 H-imidazol- 1 -yl, lH-l,2,4-triazol-l-yl, [l-(hydroxymethyl)-3-methylbutyl] amino, cyclopentylamino, (1,
  • the invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • a 3 is O or S
  • R 3 is hydrogen, fluorine or methyl
  • R4 is hydrogen, chlorine, bromine, fluorine or methoxy
  • R 5 is -O-(CH 2 ) m -NR 13a R 13b ;
  • R 13 b is selected from the group consisting of 1-piperidinyl, 1-pyrrolidinyl, 2-methylpyrrolidin-l-yl, (2S)-2-methylpyrrolidin-l-yl, (2R)-2-methylpyrrolidin-l-yl, 4- isopropylpiperazin-1-yl, 4-methylpiperidin-l-yl, 2-methylpiperidin-l-yl, 2-(pyrrolidin-l- ylmethyl)pyrrolidin- 1 -yl, 4-cyclopentylpiperazin- 1 -yl, 3 -(dimethylamino)pyrrolidin- 1 -yl, 4-(2-pyrrolidin-l-ylethyl)piperazin-l-yl, 1-azepanyl, 2,6-dimethylpiperidin-l-yl, (2S)-2- (pyrrolidin-l-yhnethyl)pyrrolidm-l-yl, 2-iso
  • -NR15R16 is selected from the group consisting of 1-piperidinyl, 2- methylpyrrolidin-1-yl, 1-pyrrolidinyl, 1-azepanyl, 2-methylpiperidin-l-yl, (3,5- dimethyl)piperidin-l-yl, hexyl(methyl)amino, benzyl(methyl)amino, 2-azaspiro[5.5]undec- 2-yl, 7,8-dimethyl-lazaspiro[4.4]non-l-yl, 2-oxopyrrolidin-l-yl, anilino, 2-methyl-lH- imidazol-1-yl, lH-l,2,4-triazol-l-yl, [l-(hydroxymethyl)-3-methylbutyl]amino, cyclopentylamino, (l,3-dimethylbutyl)amino, (cyclopropylmethyl)(propyl)amino, 2,6- dimethyl
  • the invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • a 1 is CH or C-F
  • a 3 is O or S; R 3 is hydrogen or methyl;
  • R4 is hydrogen or fluorine;
  • R 5 is -O-(CH 2 )m-NR 13a R 13b ;
  • -NR 1 SR 1 ⁇ is 1-piperidinyl, 1-pyrrolidinyl, 2-methylpyrrolidin-l-yl, 7,8-dimethyl- 1 azaspiro [4.4]non- 1 -yl, IH-1 ,2,4-triazol- 1 -yl, [ 1 -(hydroxymethyl)-3 -methylbutyl] amino, 2,6-dimethylpiperidin-l-yl, benzylamino, sec-butyl(propyl)amino, (4aR, 8aS)- octahydroisoquinolin-2( 1 H)-yl and (2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl.
  • -NR 1 ⁇ R 18 is selected from the group consisting of 1-piperidinyl, 2-oxopyrrolidin- 1-yl, (cyclopropylmethyl)(propyl)amino, cyclopentylamino, benzylamino, (4- cyclopentyl)piperazin-l-yl, 4-mo ⁇ holinyl and 4,4-difluoropiperidin-l-yl.
  • the present invention relates to compounds of formula
  • R ⁇ a is NR ⁇ R16 5 R15 an( j R16 being as defined here above in the specification.
  • w is equal to 1.
  • L is -(CH ⁇ ) 1n -NR 13a R 13b , m, R 13a and R 13b being as defined here above in the specification.
  • m is equal to 3.
  • the present invention relates to compounds of formula (Ii) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • R 1 ⁇ is NR 15 Rl 6 ⁇ R 15 an( [ R 16 being as defined here above in the specification.
  • w is equal to 1.
  • L is -(CH 2 VNR 1 3a R 13b 5 m> R 13a an d R 13b being as defined here above in the specification.
  • m is equal to 3.
  • the present invention relates to compounds of formula (Ij) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • RlOb is an amino group.
  • R 10b is NR 15 R 16 , R 15 and R 16 being as defined here above in the specification.
  • L is -(CH2) m -NR 13a R 13b , m, R 13a and R 13b being as defined here above in the specification.
  • m is equal to 3.
  • the present invention relates to compounds of formula (Ik) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • R 10b is NR 15 R 16 , R 15 and R 16 being as defined here above in the specification.
  • L is -(CH2) m -NR 13a R 13b , m, R 13a and R 13b being as defined here above in the specification.
  • m is equal to 3.
  • the present invention relates to compounds of formula (II) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • RI l a is an amino group.
  • R 1 l a is NR 17 R 18 , R 17 and R 18 being as defined here above in the specification.
  • r is equal to 1 or 2.
  • L is -(CH2) m -NR 13a R 13b , m, R 13a and R 13b being as defined here above in the specification.
  • m is equal to 3.
  • the present invention relates to compounds of formula (Im), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • L is as defined hereabove in the specification; r is an integer comprised between 1 and 4; R 10c is a C 1-6 alkyl;
  • R 1 la is an amino group.
  • R 1 la is NR 17 R 18 , R 17 and R 18 being as defined here above in the specification.
  • r is equal to 1 or 2.
  • L is -(CH2) m -NR 13a R 13b , m, R 13a and R 13b being as defined here above in the specification.
  • m is equal to 3.
  • the present invention relates to compounds of formula (In) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • RlOc is a Ci ⁇ alkyl
  • R 1 lb is an amino group.
  • R 1 lb is NR 17 R 18 , R 17 and R 18 being as defined here above in the specification.
  • r is equal to 1 or 2.
  • L is -(CH2) m -NR 13a R 13b , m, R 13a and R 13b being as defined here above in the specification.
  • m is equal to 3.
  • the present invention relates to compounds of formula (Io), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • R 1 lb is an amino group.
  • R 1 lb is NR 17 R 18 , R 17 and R 18 being as defined here above in the specification.
  • r is equal to 1 or 2.
  • L is -(CH2) m -NR 13a R 13b , m, R 13a and R 13b being as defined here above in the specification.
  • m is equal to 3
  • Preferred compounds of formula (I) according to the invention are: l-(3- ⁇ 4-[4-(piperidin-l-ylmethyl)-l,3-oxazol-2-yl]phenoxy ⁇ propyl)piperidine; 1 -[3-(4- ⁇ 4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl ⁇ phenoxy)propyl]piperidine; l-(3- ⁇ 4-[4-(pyrrolidin-l -ylmethyl)-l ,3-oxazol-2-yl]phenoxy ⁇ propyl)piperidine;
  • the "pha ⁇ naceutically acceptable salts" according to the invention include therapeutically active, non-toxic acid salt forms which the compounds of formula (I) are able to form.
  • the acid addition salt form of a compound of formula (I) that occurs in its free form as a base can be obtained by treating the free base with an appropriate acid such as an inorganic acid, for example, a hydrohalic such as hydrochloric or hydrobromic, sulfuric, nitric, phosphoric and the like; or an organic acid, such as, for example, acetic, trifiuoroacetic, hydroxyacetic, propanoic, lactic, pyruvic, malonic, succinic, maleic, fumaric, malic, tartaric, citric, methanesulfonic, ethanesulfonic, benzenesulfonic, p- toluenesulfonic, cyclamic, salicylic, p-aminosalicylic, pamoic, and the like.
  • an appropriate acid such as an inorganic acid, for example, a hydrohalic such as hydrochloric or hydrobromic, sulfuric, nitric, phosphoric and the
  • Preferred salt forms are maleate, tartrate, fumarate, chlorhydrate, and trifluoroacetate.
  • solvates include for example hydrates, alcoholates and the like.
  • stereogenic center may be present in a R or a S configuration, said R and S notation is used in correspondence with the rules described in Pure Appl. Chem., 45 (1976) 11-30.
  • the invention also relates to all stereoisomeric forms such as enantiomeric and diastereoisomeric forms of the compounds of formula (I) or mixtures thereof (including all possible mixtures of stereoisomers).
  • reference to a compound or compounds is intended to encompass that compound in each of its possible isomeric forms and mixtures thereof, unless the particular isomeric form is referred to specifically.
  • the invention also includes within its scope prodrug forms of the compounds of formula (I) and its various sub-scopes and sub-groups.
  • prodrug as used herein includes compound forms which are rapidly transformed in vivo to the parent compound according to the invention, for example, by hydrolysis in blood.
  • Prodrugs are compounds bearing groups which are removed by biotransformation prior to exhibiting their pharmacological action. Such groups include moieties which are readily cleaved in vivo from the compound bearing it, which compound after cleavage remain or becomes pharmacologically active. Metabolically cleavable groups form a class of groups well known to practitioners of the art. They include, but are not limited to such groups as alkanoyl (i.e.
  • acetyl, propionyl, butyryl, and the like unsubstituted and substituted carbocyclic aroyl (such as benzoyl, substituted benzoyl and 1- and 2-naphthoyl), alkoxycarbonyl (such as ethoxycarbonyl), trialklysilyl (such as trimethyl- and triethylsilyl), monoesters formed with dicarboxylic acids (such as succinyl), phosphate, sulfate, sulfonate, sulfonyl, sulf ⁇ nyl and the like.
  • carbocyclic aroyl such as benzoyl, substituted benzoyl and 1- and 2-naphthoyl
  • alkoxycarbonyl such as ethoxycarbonyl
  • trialklysilyl such as trimethyl- and triethylsilyl
  • monoesters formed with dicarboxylic acids such as succinyl
  • the compounds bearing the metabolically cleavable groups have the advantage that they may exhibit improved bioavailability as a result of enhanced solubility and/or rate of absorption conferred upon the parent compound by virtue of the presence of the metabolically cleavable group.
  • T. Higuchi and V. Stella "Pro-drugs as Novel Delivery System", Vol. 14 of the A.C.S. Symposium Series; "Bioreversible Carriers in Drug Design", ed. Edward B. Roche, American Pharmaceutical Association and Pergamon Press, 1987.
  • compounds of general formula (I) wherein R 2 is (IF), A 3 is an oxygen atom or a sulfur atom, hereafter referred to as compounds of formula (Id), may be obtained after several reaction steps starting from compounds (XI) and (XII), via intermediates (XIII), as shown in Scheme 9.
  • compounds of general formula (Id) may be obtained from compounds (XI) and (Xllbis), via intermediates (XHIbis), as shown in Scheme 9bis.
  • R 1 , R 3 , R 4 , R 5 , R 12a , R 12b , R 13a , R 13b , R 15 and Rl6, A 1 and A 3 , w, r, z and t, and provisos are as defined for compounds of general formula (I);
  • R 18 - R4' is R4 as defined above in the specification for compounds of formula (I); or is -O- (CH 2 ) n -Cl or hydroxy or O-CH 2 -phenyl; when R 4 ' is C ⁇ .4 alkoxy, it is preferably a methoxy.
  • R.5' is R.5 as defined above in the specification for compounds of formula (I); or -O- (CH2)m"Cl or hydroxy or C ⁇ .4 alkoxy or O-CHrj-phenyl or a chlorine atom; when R ⁇ ' is Cj_4 alkoxy, it is preferably a methoxy.
  • - Q is hydrogen, COOR', CO-NR15R16 or a halogen atom, said halogen atom being preferably a chlorine or a bromine atom;
  • R' is hydrogen or a C 1.4 alkyl, preferably a methyl or an ethyl.
  • - X is a halogen atom, preferably chlorine or bromine atom
  • compounds (XI) when A ⁇ is a sulfur atom, compounds (XI) may be obtained by reacting compounds of formula (XI), in which A ⁇ is an oxygen atom, with a sulfur-releasing reagent according to any conventional method known to the man skilled in the art.
  • reaction represented in Scheme 9 and Scheme 9 bis is applied to compounds of formula (XI) wherein A ⁇ is CH.
  • Compounds (XI), wherein A ⁇ is an oxygen or a sulfur atom and R ⁇ ' is -O-(CH2) n - Cl or R5' is -O-(CH2) m -Cl, may be obtained from the corresponding hydroxy-amides, i.e. (XI) wherein R4' or R5' is hydroxy, according to the same procedure described in step (iiib) of Scheme 15, or according to conventional methods known to the man skilled in the art. Hydroxy-amides of formula (XI) wherein R4' or R ⁇ ' is hydroxy are commercially available or obtained according to conventional methods known to the man skilled in the art.
  • Compounds (XIII), wherein A ⁇ is an oxygen or a sulfur atom, Q is halogen, preferably chlorine or bromine, w is equal to 1, t is equal to 0; R ⁇ ' is -O-(CH2) n -Cl or R ⁇ ' is -O-(CH2) m -Cl, may be obtained from the reaction of compounds (XI) and compounds (XII), wherein Q is as defined for compounds (XIII), according to methods described by Prager et al. in J. Chem.Soc, Perkin Trans. 1, 1997, 17, 2665.
  • Compounds (XHIbis), wherein A ⁇ is an oxygen or a sulfur atom, Q' is a halogen atom, preferably a chlorine or a bromine atom, w is equal to 1, t is equal to 0; R ⁇ ' is -O- (CH2) n -Cl or R5' is -O-(CH2) m -Cl, may be obtained from the reaction of compounds (XI) and compounds (Xllbis), wherein Q' is as defined for compounds (XHIbis), according to methods described by Prager et al. in J. Chem.Soc, Perkin Trans. I, 1997, 17, 2665.
  • compounds (Id) may be obtained via intermediates (XIII) or (XHIbis), according to methods represented in Scheme 10 and Scheme lObis.
  • R a and R ⁇ are H, C ⁇ .4 alkyl, or R a and R ⁇ are linked together to form a C2-.3 alkylene;
  • Rl is hydrogen or halogen, preferably a fluorine atom
  • R 3 is hydrogen, halogen, C 1.4 alkyl or C ⁇ .4 alkoxy
  • R 4 ' is hydrogen, halogen, C ⁇ .4 alkyl, C 1.4 alkoxy or trifluoromethyl
  • R ⁇ ' is respectively R ⁇ as defined in general formula (I), or R 5 ' is hydroxy, O-CH2-Phenyl or C 1.4 alkoxy, O-(CH2) n -Cl or O- (CH2) n -NRl 3a R 13b , or chlorine
  • R 4 and R 5 are as defined above in the specification for compounds of formula (I);
  • R 1 1 is -(CE ⁇ V
  • RI 1, R ⁇ and R ⁇ are as defined above in the specification for compounds of formula (I);
  • Rl 1, R ⁇ and R ⁇ are as defined above in the specification for compounds of formula (I);
  • reaction conditions to afford compound (Id) may vary.
  • intermediates (XIII) may be treated with a deprotecting agent, for example boron tribromide or H 2 -PdZC system according to conventional methods known to the man skilled in the art to afford the same intermediates (XIII) wherein R ⁇ 'or R ⁇ ' is hydroxy.
  • Said intermediates may be converted to compound (Id) according to methods that we have already described for step (iii) of Scheme 15. In a similar manner, the above described reactions could be applied to compound (Xlllbis).
  • RlO in RlO-M is is amino, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, C3_g cycloalkyl, 3-8-membered heterocycloalkyl, C 1-6 -alkyl aryl, Q.g-alkyl heteroaryl, C 2-6 -alkenyl aryl, C 2-6 -alkenyl heteroaryl, C 2-6 -alkynyl aryl, C 2-6 -alkynyl heteroaryl, C 1-6 -alkyl cycloalkyl, Cj_6-alkyl heterocycloalkyl, C 2-6 -alkenyl cycloalkyl, C 2-6 -alkenyl heterocycloalkyl, C 2-6 -alkynyl cycloalkyl, C 2-6 alkynyl, heterocycloalkyl, C 1-6 -alkyl carboxy, C
  • Rl 1 in Rl 1-M is is amino, C ⁇ . ⁇ alkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, heteroaryl, C3_g cycloalkyl, 3-8-membered heterocycloalkyl, C 1-6 - alkyl aryl, C 1-6 -alkyl heteroaryl, C 2-6 -alkenyl aryl, C 2-6 - a lkenyl heteroaryl, C 2-6 -alkynyl aryl, C 2-6 -alkynyl heteroaryl, C 1-6 -alkyl cycloalkyl, C 1-6 -alkyl heterocycloalkyl, C 2-6 - alkenyl cycloalkyl, C 2-6 - a lkenyl heterocycloalkyl, C 2-6 -alkynyl cycloalkyl, C 2-6 alkynyl and heterocycloalkyl, C 1-6 -al
  • Compounds of general formula (XV) or (XVbis) may be prepared according to methods described by Hodgett and Kershaw in Org. Lett. 2002, 4, 2905, or Young at al. in Tetrahedron Lett. 2004, 45, 3797, or according to conventional methods known to the man skilled in the art.
  • -X is a halogen atom, preferably a halogen atom different from fluorine;
  • R 4 ' is R 4 as defined above in the specification for compounds of formula (I); or is -O-(CH2) n -Cl or hydroxy or O-CH2-Phenyl.
  • R 4 ' is C1.4 alkoxy, it is preferably a methoxy;
  • R5' is R ⁇ as defined above in the specification for compounds of formula (I); or - O-(CH2) m -Cl or hydroxy or C 1.4 alkoxy or O-CH2-Phenyl or a chlorine atom.
  • R ⁇ ' is C ⁇ _4 alkoxy, it is preferably a methoxy
  • compounds (XIVa) react with a boron reagent, such as bis(pinacolato)diboron in the presence of a palladium-based catalyst to provide intermediates (XIV) according to method described by Ishiyama, T. et al. in J. Org. Chem. 1995, 60, 7508.
  • a boron reagent such as bis(pinacolato)diboron
  • intermediates (XIII) are reacted with HNR 15 R 16 in the presence of a base, such as triethylamine, to afford intermediates (XIIIa), wherein R.4' or R 5 ' is - OH.
  • intermediates (XIII) may react with HNR 15 R 16 wherein R 15 and R 16 are linked together to form a C ⁇ - ⁇ alkylene, one methylene of the alkylene being optionally replaced by a carbonyl, such as pyrrolidone in the presence of a base such as sodium hydride in a solvent such as dimethylformamide to afford intermediate (XIIIa).
  • R 4 ' is -O-(CH2) n -Cl or R 5 ' is -O-(CH2) m -Cl according to conventional methods known to the man skilled in the art or according to conditions described for step (iiib) of Scheme 15.
  • a halogen-releasing agent such as N-bromosuccinimide or N- chlorosuccinimide
  • compounds (Id) wherein A ⁇ is an oxygen or a sulfur atom, Rl 1 is - r j s e q Ua i to 1, and z is equal to 0 may be obtained from intermediates (XHIbis) wherein Q' is a halogen atom, preferably Cl or Br, and R 4 ' is OH or -O-(CH2) n -Cl, or R 5 ' is -OH or -O-(CH2) n -Cl, according to Scheme 12bis.
  • Scheme 12bis Reference made for step (xiii), (xiv and (xv) in Scheme 12 here above may be applied accordingly to Scheme 12bis.
  • intermediates (XIII) are reacted with HNR 12a R 12b or HNR 13a R 13b to afford intermediates (XIIIc) wherein R.4' or R ⁇ ' is respectively R ⁇ or R ⁇ as defined in general formula (I).
  • intermediates (XIIIc) are hydrolysed to provide the corresponding acid intermediates (XIIId), according to conventional methods known to the man skilled in the art.
  • intermediates (XIIId) are reacted with HNR15R16 m the presence of a coupling agent, such as l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and an activating agent, such as 1-hydroxy-benzotriazole, according to conventional methods known to the man skilled in the art, to afford compounds (XIIIe) in which preferably w is equal to 0 or 1, and t is equal to 1.
  • a coupling agent such as l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
  • an activating agent such as 1-hydroxy-benzotriazole
  • Reference made respectively to steps (xvi), (xvii), (xviii), (xix) and (xx) of Scheme 13 maybe applied to Scheme 13bis.
  • intermediates (XIIIe) may correspond to compounds (Id), wherein in RlO, w is equal to 0 or 1 and t is equal to 1.
  • intermediates (Xlllebis) may correspond to compounds (Id), wherein in R* 1, r is equal to 0 or 1 and z is equal to 1.
  • Compounds of formula (Id), wherein R ⁇ is Cj. ⁇ alkyl sulfonyl, C ⁇ _ ⁇ alkyl sulfinyl may be obtained by reacting compounds (Id), wherein R ⁇ 1 is C ⁇ _ ⁇ alkyl sulfanyl, using an oxidizing agent in stoechiometric or excess amount, such as m-chloroperbenzoic acid, according to Brown, TJ. et al. in J. Med. Chem. 1992, 35, 3613-3624 or any methods known to the man skilled in the art.
  • Compounds of formula (Id), wherein R 11 is C ⁇ _g alkyl aminosulfonyl or C ⁇ . ⁇ aryl aminosulfonyl may be obtained by the reaction of compound (Id) wherein R ⁇ 1 is an amino group with a C ⁇ . ⁇ alkyl sulfonyl chloride or C 1-6 aryl sulfonyl chloride according to conventional methods known to the man skilled in the art.
  • Compounds (Id) wherein R 1 ⁇ is Cj _ 6 alkyl aminosulfonyl or C ⁇ . ⁇ aryl aminosulfonyl may be obtained in a similar manner, according to Hulin, B. et al. in J. Med. Chem.1992, 35, 1853-1864.
  • R 1 , R 3 , R 12a , R 12b , R 13a , R 13b , A 1 and A 3 , r and z, and provisos are as defined for compounds of general formula (I);
  • R 4 ' is -O-(CH 2 ) n -Cl or R 5 ' is -O-(CH 2 ) m -Cl or a chlorine atom;
  • - R 10 is Ci_4 alkyl.
  • R 10 is a methyl;
  • R' is alkyl, preferably a methyl and X is a halogen atom, preferably a chlorine or bromine atom.
  • intermediates (XHIbis) are reacted with a reducing agent, such as lithium borohydride, according to conventional methods known to the man skilled in the art, to afford intermediate (XIX).
  • a reducing agent such as lithium borohydride
  • alcohols of formula (XIX) are reacted with amide of formula HNR17R18 S wherein Rl ⁇ and Rl 8 are linked together to form a C3.6 alkylene, one methylene of the alkylene adjacent to the nitrogen being replaced by a carbonyl, such as in pyrrolidone in the presence of para-tohxene sulfonic acid in a solvent such as toluene to afford intermediate (XX).
  • intermediates of formula (XIII) wherein A* is CH and R 4 ' or R.5' is - O-CH2-phenyl may be converted to intermediates of same general formula as intermediates (XIII) wherein R 4 ' or R ⁇ ' is -OH, using a catalyst, for example palladium on charcoal (Pd/C or Pd(OH) 2 /C), in the presence of a solvent such as methanol or ethanol under a hydrogen atmosphere.
  • a catalyst for example palladium on charcoal (Pd/C or Pd(OH) 2 /C
  • intermediates (XIII) wherein A* is CH and R 4 ' or R ⁇ ' is OH may be converted into intermediates (XIII), wherein A ⁇ is CH and R 4 ' is -O-(CH2)n-Cl or R5 ' is -O-(CH2) m -Cl by reacting with a di-haloalkane respectively of general formula -Y-(C ⁇ ) n -Cl or Y-(CH2) m -Cl, wherein Y is a halogen except a fluorine, in the presence of a base.
  • Y is a bromine atom. This reaction may occur according to methods described by Walsh et al. in J. Med.Chem. 1989, 32, 105.
  • intermediates (XIII) wherein A 1 is CH and R 4 ' is -O-(CH2) n -Cl or R 5 ' is -O-(CH2) m -Cl may react respectively with HNR 12a R 12b or with HNR 13a R 13b in the presence of a base such as triethylamine or potassium carbonate in acetonitrile or acetone as solvent, to afford compounds of formula (Id).
  • the reaction may be performed according to conventional methods known to the man skilled in the art.
  • a base such as potassium tert-butylate, cesium carbonate or sodium hydride
  • a solvent such as dimethylformamide or tetrahydrofuran
  • a palladium- or a copper- based catalyst may be added, according to methods described by Penning et al. in J. Med. Chem. 2000, 43,721.
  • diethylazodicarboxylate in the presence of triphenylphosphine in a solvent such as dichloromethane may be used.
  • Rl, R 3 , R 12a , R 12b , R 13a , R 13b , A 1 and A 3 , r and z, and provisos are as defined for compounds of general formula (I); - R 4 ' is -O-(CH2) n -Cl or R 5 ' is -O-(CH2) m -Cl or a chlorine atom;
  • R 10 is -CH 2 -NR 15 R 16 ;
  • R 1 1 i is H or Ci _4 alkyl.
  • R 1 1 is a methyl; may be obtained after several reaction steps starting from compounds (XIII) wherein Q is a hydroxy group or chlorine atom, w is equal to 0, R 4 ' is -O-(CH2) n -Cl or R 5 ' is -O-(CH2) m -Cl, as shown in Scheme 16.
  • some compounds of general formula (I) may be prepared by functional group transformation.
  • a halide-releasing agent such as N-bromosuccinimide
  • a solvent such as acetonitrile
  • the present invention relates to a compound of formula (VII), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • Y" is halogen, hydroxy or C 1.4 alkoxy
  • RI is hydrogen or halogen
  • R 3 is hydrogen, halogen, C 1.4 alkyl or C].4 alkoxy
  • R4' is hydrogen, halogen, C 1.4 alkyl, C ⁇ .4 alkoxy, O-CH2-Phenyl; or -O-(CH2) n - Cl or -O-(CH2) n -NR 12a R 12b ;
  • R 5 ' is hydrogen, halogen, -O-CH2-Phenyl, -O-(CH2) m -Cl or -O-(CH 2 ) m - NR 13a R 13b , each CH2 in -O-(CH2) m -NR 13a R 13b being optionally substituted by one or two Ci .4 alkyl;
  • R ⁇ 2a and R ⁇ 2b are linked together to form a C ⁇ - - ⁇ alkylene, each methylene of the alkylene being optionally substituted by a Ci .4 alkyl;
  • Rl 3a and R* 3b are linked together to form a C3_g alkylene, each methylene of the alkylene being optionally substituted by a Cj .4 alkyl, an amino group or C 1-6 alkyl amino, one methylene of the alkylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Ci _g alkyl or Ci _g alkyl amino; n and m are independently an integer comprised between 2 and 8; with the proviso that R4' is -0-(CH 2 ) H -NR 12a R 12b , -O-(CH 2 ) n -Cl, Or-O-CH 2 -
  • a 1 is CH or C(CEB). More preferably, A 1 is CH.
  • a 2 is O.
  • Y" is preferably a hydroxy, a chlorine atom or a methoxy.
  • the present invention relates to a compound of formula (XI), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • a 3 is O or S
  • RI is hydrogen or halogen
  • R 3 is hydrogen, halogen, C i_4 alkyl or C ⁇ .4 alkoxy;
  • R4' is hydrogen, halogen, Cj .4 alkyl, C ⁇ .4 alkoxy, hydroxy, -O-CH2-Phenyl; -O- (CH 2 ) n -Cl or -O-(CH 2 ) n -NR 12a R 12b ;
  • R ⁇ ' is hydrogen, halogen, C ⁇ .4 alkoxy, hydroxy, -O-CH2-Phenyl, -O-(CH2) m -Cl or -0-(CH 2 ) J11 -NR 13a R 13b , each CH 2 in -O-(CH 2 ) m -NR 13a R 13b being optionally substituted by one or two C 1.4 alkyl;
  • Rl2a and Rl2b ace linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by a C ⁇ .4 alkyl;
  • R i 3a and Rl3b are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by a Cj .4 alkyl, an amino group or C ⁇ . ⁇ alkyl amino, one methylene of the alkylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C 1-6 alkyl amino; n and m are independently an integer comprised between 2 and 8; with the proviso that R 4 ' is -O-(CH 2 ) n -NR 12a R 12b , -O-(CH 2 ) n -Cl, or -0-CH 2 - Phenyl when R 5 ' is hydrogen and that R 5 ' is -O-(CH 2 ) m -NR 13a R 13b , -O-(CH 2 ) m -Cl, or -O-CH 2 -Phenyl when R4'
  • a 1 is CH or C(CHS). More preferably, A 1 is CH. Preferably, A 3 is O.
  • R5' is halogen, it is preferably a chlorine atom.
  • R4 is a Cj .4 alkoxy, it is preferably a methoxy.
  • the present invention relates to a synthetic intermediate of formula (XIII) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • a 1 is CH, C(CH3) or C-halogen
  • a 3 is O or S
  • R' is hydrogen or Cj .4 alkyl;
  • Rl is hydrogen, halogen or C 1.4 alkyl;
  • R 3 is hydrogen
  • R4' is hydrogen, halogen, C 1.4 alkyl, Cj .4 alkoxy or -O-(CH 2 ) n -Cl.
  • R 5 ' is hydrogen, hydroxy, -O-(CH2)m-halogen, -O-CH2-Phenyl, or -0-(CH ⁇ ) 1n - NRl3aRl3b ;
  • R 1 5 is hydrogen or a C ⁇ _g alkyl;
  • R!6 is aryl, heteroaryl, Cj.g alkyl, C ⁇ _ ⁇ alkyl cycloalkyl, C3_g cycloalkyl, C ⁇ _ ⁇ alkyl aryl or a CH2- heteroaryl; or R15 and R 1 ⁇ are linked together to form a C ⁇ . ⁇ alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by C ⁇ _g alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C3_g cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3..8 cycloalkyl or a carbonyl and another methylene being optionally substitute
  • R! ° is Ci_g alkyl, C 1-6 alkyl cycloalkyl or C ⁇ . ⁇ alkyl aryl; or RI 7 and Rl 8 are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C3.6 cycloalkyl; w is an integer equal to 0 or 1 ; t is an integer equal to 0 or 1 ; z is an integer equal to 0 or 1; and m is an integer equal to 2, 3 or 4; and provided that when R 5 ' is O-CH2-Phenyl, R 4 ' is halogen and that compound (XIII) is different from 4-(2-oxazolylphenol), 4-(4-chloro
  • the present invention relates to a synthetic intermediates of formula (XHIbis), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
  • a 1 is CH or N
  • a 3 is O or S
  • R' is hydrogen or Cj readily4 alkyl
  • R 1 is hydrogen
  • R 5 ' is hydrogen, halogen, -O-(CH2) m -halogen or -O-(CH2) m -NR 13a R 13b ;
  • R 13a and R 13 ° are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C ⁇ .4 alkyl, an amino group or C 1-6 alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl, Cj- ⁇ cycloalkyl or C ⁇ . ⁇ alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C- ⁇ . ⁇ alkylene.
  • R.15 is hydrogen or a C i_g alkyl
  • R.16 is aryl, a heteroaryl, Ci_g alkyl, C3. g cycloalkyl, C 1-6 alkyl cycloalkyl, Cj_g alkyl aryl or a CH2- heteroaryl; or R!5 and R ⁇ are linked together to form a C ⁇ - ⁇ alkylene, each methylene of the alkylene being optionally substituted by one or two C ⁇ j ⁇ .
  • R!8 is C ⁇ _g alkyl, C 1-6 alkyl cycloalkyl or C ⁇ . ⁇ alkyl aryl; or R!7 and R ⁇ are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C ⁇ g alkyl or C3..6 cycloalkyl; t is an integer equal to 0 or 1; m is an integer equal to 2, 3 or 4; z is an integer equal to 0 or 1; and r is an integer equal to 0 or 1.
  • the present invention relates to compounds of formula (Id),
  • the invention relates to a synthetic intermediate selected from the group consisting of
  • the present invention relates to the use of a synthetic intermediate of formula (XIII) or (XHIbis) for the preparation of compound of formula (I).
  • the compounds according to the invention are useful for the treatment and prevention of diseases or pathological conditions of the central nervous system including mild-cognitive impairment, Alzheimer's disease, learning and memory disorders, cognitive disorders, attention deficit disorder, attention-deficit hyperactivity disorder,
  • Parkinson's disease schizophrenia, dementia, depression, epilepsy, seizures, convulsions, sleep/wake disorders, narcolepsy, and/or obesity.
  • an antiepileptic drug may be useful in the treament of epilepsy, seizure or convulsions. It is known from literature that the combination of H3 -receptor ligands with an AED may produce additive synergistic effects on efficacy with reduced side-effects such as decreased vigilance, sedation or cognitive problems.
  • compounds of general formula (I) alone or in combination with a histamine Hj-receptor antagonist may also be used for the treatment of upper airway allergic disorders.
  • (I) alone or in combination with muscarinic receptor ligands and particularly with a muscarinic M2-receptor antagonist, may be useful for the treatment of cognitive disorders
  • compounds of general formula (I) displaying NO-donor properties, alone or in combination with a nitric oxide (NO) releasing agent may be useful in the treatment of cognitive dysfunctions.
  • Compounds of general formula (I) may also be used in the treatment of sleep/wake and arousal/vigilance disorders such as hypersomnia, and narcolepsy.
  • compounds of general formula (I) may be used in the treatment of all types of cognitive-related disorders.
  • compounds of general formula (I) may be used for the treatment of cognitive dysfunctions in diseases such as mild cognitive impairment, dementia, Alzheimer's disease, Parkinson's disease, Down's syndrome as well as for the treatment of attention-deficit hyperactivity disorder.
  • compounds of general formula (I) may also be used for the treatment of psychotic disorders, such as schizophrenia; or for the treatment of eating disorders, such as obesity; or for the treatment of inflammation and pain; or for the treatment of anxiety, stress and depression; or for the treatment of cardiovascular disorders, for example, myocardial infarction.
  • compounds of formula (I) according to the present invention may be used as a medicament.
  • the present invention concerns the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof or of a pharmaceutical composition comprising an effective amount of said compound for the manufacture of a medicament for the treatment and prevention of mild-cognitive impairement, Alzheimer's disease, learning and memory disorders, attention-deficit hyperactivity disorder, Parkinson's disease, schizophrenia, dementia, depression, epilepsy, seizures, convulsions, sleep/wake disorders, cognitive dysfunctions, narcolepsy, hypersomnia, obesity, upper airway allergic disorders, Down's syndrome, anxiety, stress, cardiovascular disorders, inflammation and pain.
  • the present invention concerns the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising an effective amount of said compound for the manufacture of a medicament for the treatment of cognitive dysfunctions in diseases such as mild cognitive impairment, dementia, Alzheimer's disease, Parkinson's disease, Down's syndrome as well as for the treatment of attention-deficit hyperactivity disorder.
  • the methods of the invention comprise administration to a mammal (preferably human) suffering from above mentioned conditions or disorders, of a compound according to the invention in an amount sufficient to alleviate or prevent the disorder or condition.
  • the compound is conveniently administered in any suitable unit dosage form, including but not limited to one containing 3 to 3000 mg of active ingredient per unit dosage form.
  • treatment includes curative treatment and prophylactic treatment.
  • curative is meant efficacy in treating a current symptomatic episode of a disorder or condition.
  • prophylactic is meant prevention of the occurrence or recurrence of a disorder or condition.
  • cognitive disorders refers to disturbances of cognition, which encompasses perception, learning and reasoning or in other terms the physiological (mental/neuronal) process of selectively acquiring, storing, and recalling information.
  • ADHD attention-deficit hyperactivity disorder
  • ADD attention-deficit hyperactivity disorder
  • AD Alzheimer's disease
  • age is the most important risk factor for AD; the number of people with the disease doubles every 5 years beyond age 65.
  • Three genes have been discovered that cause early onset (familial) AD.
  • Other genetic mutations that cause excessive accumulation of amyloid protein are associated with age-related (sporadic) AD.
  • Symptoms of AD include memory loss, language deterioration, impaired ability to mentally manipulate visual information, poor judgment, confusion, restlessness, and mood swings.
  • AD Alzheimer's disease
  • the early symptoms of AD which include forgetfulness and loss of concentration, are often missed because they resemble natural signs of aging.
  • the expression "Parkinson's disease" (PD) as used herein refers to a group of conditions called motor system disorders, which are the result of the loss of dopamine- producing brain cells.
  • the four primary symptoms of PD are tremor, or trembling in hands, arms, legs, jaw, and face; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks.
  • PD usually affects people over the age of 50. Early symptoms of PD are subtle and occur gradually. In some people the disease progresses more quickly than in others. As the disease progresses, the shaking, or tremor, which affects the majority of PD patients may begin to interfere with daily activities. Other symptoms may include depression and other emotional changes; difficulty in swallowing, chewing, and speaking; urinary problems or constipation; skin problems; and sleep disruptions.
  • Down's syndrome refers to a chromosome abnormality, usually due to an extra copy of the 21st chromosome. This syndrome, usually but not always, results in mental retardation and other conditions.
  • mental retardation refers to a below-average general intellectual function with associated deficits in adaptive behavior that occurs before age 18.
  • micro-cognitive impairement refers to a transitional stage of cognitive impairment between normal aging and early Alzheimer's disease. It refers particularly to a clinical state of individuals who are memory impaired but are otherwise functioning well and do not meet clinical criteria for dementia.
  • the term "obesity” as used herein refers to a body mass index (BMI) which is greater than 30 kg/m ⁇ .
  • the term “dementia” as used herein refers to a group of symptoms involving progressive impairment of brain function.
  • American Geriatrics Society refers to dementia as a condition of declining mental abilities, especially memory. The person will have problems doing things he or she used to be able to do, like keep the check book, drive a car safely, or plan a meal. He or she will often have problems finding the right words and may become confused when given too many things to do at once. The person with dementia may also change in personality, becoming aggressive, paranoid, or depressed.
  • schizophrenia refers to a group of psychotic disorders characterized by disturbances in thought, perception, attention, affect, behavior, and communication that last longer than 6 months. It is a disease that makes it difficult for a person to tell the difference between real and unreal experiences, to think logically, to have normal emotional responses to others, and to behave normally in social situations.
  • anxiety refers to a feeling of apprehension or fear. Anxiety is often accompanied by physical symptoms, including twitching or trembling, muscle tension, headaches, sweating, dry mouth, difficulty swallowing and/or abdominal pain.
  • neuropsy refers to a sleep disorder associated with uncontrollable sleepiness and frequent daytime sleeping.
  • depression refers to a disturbance of mood and is characterized by a loss of interest or pleasure in normal everyday activities. People who are depressed may feel "down in the dumps" for weeks, months, or even years at a time. Some of the following symptoms may be symptoms of depression : persistent sad, anxious, or "empty" mood; feelings of hopelessness, pessimism; feelings of guilt, worthlessness, helplessness; loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex; decreased energy, fatigue, being “slowed down”; difficulty concentrating, remembering, making decisions; insomnia, early-morning awakening, or oversleeping; appetite and/or weight loss or overeating and weight gain; thoughts of death or suicide; suicide attempts; restlessness, irritability; persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain.
  • epilepsy refers a brain disorder in which clusters of nerve cells, or neurons, in the brain sometimes signal abnormally.
  • epilepsy the normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and behavior or sometimes convulsions, muscle spasms, and loss of consciousness.
  • Epilepsy is a disorder with many possible causes. Anything that disturbs the normal pattern of neuron activity - from illness to brain damage to abnormal brain development - can lead to seizures.
  • Epilepsy may develop because of an abnormality in brain wiring, an imbalance of nerve signaling chemicals called neurotransmitters, or some combination of these factors. Having a seizure does not necessarily mean that a person has epilepsy. Only when a person has had two or more seizures is he or she considered to have epilepsy.
  • seizure refers to a transient alteration of behaviour due to the disordered, synchronous, and rhythmic firing of populations of brain neurones.
  • migraine headache means a disorder characterised by recurrent attacks of headache that vary widely in intensity, frequency, and duration.
  • the pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. It is often accompanied by extreme sensitivity to light and sound, nausea, and vomiting.
  • Some individuals can predict the onset of a migraine because it is preceded by an "aura,” visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision.
  • People with migraine tend to have recurring attacks triggered by a lack of food or sleep, exposure to light, or hormonal irregularities (only in women). Anxiety, stress, or relaxation after stress can also be triggers.
  • migraines were linked to the dilation and constriction of blood vessels in the head.
  • Investigators now believe that migraine is caused by inherited abnormalities in genes that control the activities of certain cell populations in the brain.
  • the International Headache Society (IHS, 1988) classifies migraine with aura (classical migraine) and migraine without aura (common migraine) as the major types of migraine.
  • another embodiment of the present invention concerns a pharmaceutical composition
  • a pharmaceutical composition comprising an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable diluent or carrier.
  • one or more of the compounds of formula (I) or a pharmaceutically acceptable salt thereof is intimately admixed with a pharmaceutical diluent or carrier according to conventional pharmaceutical compounding techniques known to the skilled practitioner.
  • Suitable diluents and carriers may take a wide variety of forms depending on the desired route of administration, e.g., oral, rectal, parenteral or intranasal.
  • compositions comprising compounds according to the invention can, for example, be administered orally, parenterally, i.e., intravenously, intramuscularly or subcutaneously, intrathecally, by inhalation or intranasally.
  • compositions suitable for oral administration can be solids or liquids and can, for example, be in the form of tablets, pills, dragees, gelatin capsules, solutions, syrups, chewing-gums and the like.
  • active ingredient may be mixed with an inert diluent or a non-toxic pharmaceutically acceptable carrier such as starch or lactose.
  • these pharmaceutical compositions can also contain a binder such as microcrystalline cellulose, gum tragacanth or gelatine, a disintegrant such as alginic acid, a lubricant such as magnesium stearate, a glidant such as colloidal silicon dioxide, a sweetener such as sucrose or saccharin, or colouring agents or a flavouring agent such as peppermint or methyl salicylate.
  • a binder such as microcrystalline cellulose, gum tragacanth or gelatine
  • a disintegrant such as alginic acid
  • a lubricant such as magnesium stearate
  • a glidant such as colloidal silicon dioxide
  • a sweetener such as sucrose or saccharin
  • colouring agents or a flavouring agent such as peppermint or methyl salicylate.
  • compositions which can release the active substance in a controlled manner are in conventional form such as aqueous or oily solutions or suspensions generally contained in ampoules, disposable syringes, glass or plastics vials or infusion containers.
  • these solutions or suspensions can optionally also contain a sterile diluent such as water for injection, a physiological saline solution, oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents, antibacterial agents such as benzyl alcohol, antioxidants such as ascorbic acid or sodium bisulphite, chelating agents such as ethylene diamine-tetra-acetic acid, buffers such as acetates, citrates or phosphates and agents for adjusting the osmolality, such as sodium chloride or dextrose.
  • a sterile diluent such as water for injection, a physiological saline solution, oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents, antibacterial agents such as benzyl alcohol, antioxidants such as ascorbic acid or sodium bisulphite, chelating agents such as ethylene diamine-tetra-acetic acid, buffers such as acetates, citrates
  • the amount of active ingredient in the pharmaceutical compositions can fall within a wide range of concentrations and depends on a variety of factors such as the patient's sex, age, weight and medical condition, as well as on the method of administration.
  • the quantity of compound of formula (I) in compositions for oral administration is at least 0.5
  • % by weight can be up to 80 % by weight with respect to the total weight of the composition.
  • the daily dosage is in the range 3 to 3000 milligrams (mg) of compounds of formula (I).
  • the quantity of compound of formula (I) is in the range 3 to 3000 milligrams (mg) of compounds of formula (I).
  • (I) present is at least 0.5 % by weight and can be up to 33 % by weight with respect to the total weight of the composition.
  • the dosage unit is in the range 3 mg to 3000 mg of compounds of formula (I).
  • the daily dose can fall within a wide range of dosage units of compound of formula (I) and is generally in the range 3 to 3000 mg.
  • the specific doses can be adapted to particular cases depending on the individual requirements, at the physician's discretion.
  • the following examples illustrate how the compounds covered by formula (I) may be synthesized. They are provided for illustrative purposes only and are not intended, nor should they be construed, as limiting the invention in any manner. Those skilled in the art will appreciate that routine variations and modifications of the following examples can be made without exceeding the spirit or scope of the invention. Unless specified otherwise in the examples, characterization of the compounds is performed according to the following methods:
  • NMR spectra are recorded on a BRUKER AC 250 Fourier Transform NMR Spectrometer fitted with an Aspect 3000 computer and a 5mm ⁇ H/ ⁇ c dual probehead or BRUKER DRX 400 FT NMR fitted with a SG Indigo 2 computer and a 5 mm inverse geometry 1 H/ ⁇ C/ ⁇ N triple probehead.
  • the compound is studied in dimethylsulfoxide-dg (DMSO- d ⁇ ) or chloroform-d (CDCI3) solution at a probe temperature of 313 K or 300 K and at a concentration of 20 mg/ml.
  • the instrument is locked on the deuterium signal of dimethylsulfoxide-dg (DMSO- dg) or chloroform-d (CDCI3). Chemical shifts are given in ppm downfield from TMS taken as internal standard. HPLC analyses are performed using one of the following systems:
  • API spectra (+ or -) are performed using a FINNIGAN LCQ ion trap mass spectrometer.
  • APCI source operated at 450 °C and the capillary heater at 160 °C.
  • ESI source operated at 3.5 kV and the capillary heater at 210 °C.
  • Mass spectrometric measurements in DIP/EI mode are performed as follows: samples are vaporized by heating the probe from 50 0 C to 250 0 C in 5 min.
  • EI (Electron Impact) spectra are recorded using a FINNIGAN TSQ 700 tandem quadrupole mass spectrometer. The source temperature is set at 150 0 C.
  • Mass spectrometric measurements on a TSQ 700 tandem quadrupole mass spectrometer (Finnigan MAT) in GC/MS mode are performed with a gas chromatograph model 3400 (Varian) fitted with a split/splitless injector and a DB-5MS fused-silica column (15 m x 0.25 mm I.D., 1 ⁇ m) from J&W Scientific. Helium (purity 99.999 %) is used as carrier gas.
  • the injector (CTC A200S autosampler) and the transfer line operate at 290 and 250 0 C, respectively.
  • Sample (1 ⁇ l) is injected in splitless mode and the oven temperature is programmed as follows: 50 °C for 5 min., increasing to 280 0 C (23 °C/min) and holding for 10 min.
  • the TSQ 700 spectrometer operates in electron impact (EI) or chemical ionization (CI/CH4) mode (mass range 33 - 800, scan time 1.00 sec).
  • the source temperature is set at 150 °C.
  • Melting points are determined on a B ⁇ chi 535 or 545 Tottoli-type fusionometre, and are not corrected, or by the onset temperature on a Perkin Elmer DSC 7.
  • Preparative chromatographic separations are performed on silicagel 60 Merck, particle size 15-40 ⁇ m, reference 1.15111.9025, using Novasep axial compression columns (80 mm i.d.), flow rates between 70 and 150 ml/min. Amount of silicagel and solvent mixtures as described in individual procedures.
  • Preparative Chiral Chromatographic separations are performed on a DAICEL Chiralpak AD 20 ⁇ m, 100*500 mm column using an in-house build instrument with various mixtures of lower alcohols and C5 to C8 linear, branched or cyclic alkanes at ⁇ 350 ml/min. Solvent mixtures as described in individual procedures.
  • Methyl 4-chloro-3-oxobutanoate (4.32 ml, 37.44 mmol, 2 eq) is added to a solution of 4-(3-chloropropoxy)benzamide (4 g, 18.72 mmol, 1 eq) in propionitrile (50 ml). The mixture is heated at reflux for 48 h. The mixture is then diluted with dichloromethane and filtered.
  • a solution of lithium hydroxide hydrate (0.76 g, 18.11 mmol, 2 eq) in water (10 ml) is added to a solution of methyl ⁇ 2-[4-(3-chloropropoxy)phenyl]- 1 ,3-oxazol-4-yl ⁇ acetate ax62 (2.8 g, 9.06 mmol, 1 eq) in tetrahydrofuran (100 ml).
  • the mixture is stirred at room temperature for 1 h.
  • the mixture is then poured into water and extracted with diethyl ether (2 x 75 ml).
  • the aqueous layer is acidified with 6 N aqueous hydrochloric acid and extracted with ethyl acetate.
  • the crude product is purified by chromatography over silica gel (eluent: dichloromethane/methanol/ammonia 95:4.5:0.5) to give 0.29 g of 2- ⁇ 4-[3-(2- methylpyrrolidin- 1 -yl)propoxy]phenyl ⁇ -4-(2-oxo-2-pyrrolidin- 1 -ylethyl)- 1 , 3 -oxazole 52 as a yellow oil.
  • the mixture is cooled down to 0 °C (ice bath) and a solution of iodine (0.13 g, 0.5 mmol, 1 eq) in tetrahydrofuran (1 ml) is added dropwise.
  • a solution of iodine (0.13 g, 0.5 mmol, 1 eq) in tetrahydrofuran (1 ml) is added dropwise.
  • Methanol is added to the mixture at 0 °C until complete dissolution.
  • the solvent is removed under vacuum to give a white solid.
  • the solid is taken up into a 20 % methanolic solution of potassium hydroxide and the mixture is heated at 60 °C for 1O h.
  • the mixture is poured onto water and extracted with dichloromethane. The organic layer is dried over magnesium sulfate and the solvent is removed in vacuum.
  • the crude product is purified by chromatography over silica gel (eluent: gradient of dichloromethane/methanol/ammonia) to give 0.03 g of 2- ⁇ 4-[3-(2- methylpyrrolidin- 1 -yl)propoxy]phenyl ⁇ -4-(2-pyrrolidin- 1 -ylethyl)- 1 ,3 -oxazole 55 as an orange oil.
  • the crude material is purified by chromatography on silicagel (eluent: dichloromethane/methanol/ammonia 98:1.8:0.2) to provide 0.91 g of 4-(3-chloropropoxy) benzenecarbothioamide ax71 as a white solid.
  • the crude material is purified by chromatography on silicagel (gradient: dichloromethane/methanol/ammonia 95:4.5:0.5 to 90:9: 1) to provide 0.31 g of 4- (l-pyrrolidinylmethyl)-2- ⁇ 4-[3-(l-pyrrolidinyl)propoxy]phenyl ⁇ -l,3-thiazole 73 as a brown oil.
  • a suspension of 4-(3-chloropropoxy)benzamide ax54 (1.2 g, 5.62 mmol) and 3- bromobutan-2-one (1.02 g, 6.74 mmol) is heated in propionitrile (50 ml) at reflux for 10 days.
  • the mixture is then concentrated and the resulting black mixture is filtered through a pad of silicagel, eluting first with dichloromethane (100 ml) and then with a 96:4 mixture of dichloromethane and dimethoxymethane to afford two fractions.
  • a solution of the above mixture (330 mg) and piperidine (379 ⁇ l, 3.83 mmol) in acetonitrile (10 ml) is treated with sodium iodide (14 mg, 0.10 mmol) and stirred at 22 0 C for 1 hour, then heated at 90 °C for 20 hours.
  • the mixture is then poured into 10 ml of 0.1 N hydrochloric acid and extracted with ether (10 ml).
  • the aqueous phase is then treated with 2 M sodium hydroxide to reach pH 10 and extracted with dichloromethane (3 x 5 ml).
  • dichloromethane extracts are dried over magnesium sulfate and concentrated to afford an orange oil (300 mg), which is purified by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 96/3.6/0.4) to afford l-(3- ⁇ 4-[5-methyl-4- (piperidin-l-ylmethyl)-l,3-oxazol-2-yl]phenoxy ⁇ propyl)piperidine 87 (190 mg). Yield: 49 %.
  • a 2 N aqueous solution of sodium hydroxide (10 ml, 20.3 mmol, 3 eq) is added dropwise to a solution of ethyl 2- [4-(3 -chloropropoxy)phenyl] -1,3 -oxazole-4-carboxylate i33 (2.1 g, 6.8 mmol, 1 eq) in ethanol (60 ml).
  • the mixture is refluxed for 2h30 and the solvent is evaporated.
  • the residue is taken up in water and acidified to pH 2 with a 2 N hydrochloric acid solution.
  • Example 8 Synthesis ofN-(cyclopropylmethyl)-4-methyl-2- ⁇ 4-[3-(2-methyl-l-pyrrolidinyl) propoxy]phenyl ⁇ -N-propyl-l,3-oxazole-5-carboxamide 97 and N-(cyclopropylmethyl)-N- [(4-methyl-2- ⁇ 4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl ⁇ -l,3-oxazol-5-yl)methyl]-N- propylamine 112.
  • a suspension of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5- carboxylate ax60 (4.0 g, 12.9 mmol, 1 eq) in a 1:1 mixture of methanol and water (100 ml) is treated with a 1 M solution of sodium hydroxide (14 ml, 14 mmol, 1.1 eq). The mixture is stirred at 60 0 C during 2 h, then the mixture is concentrated. The residue is taken up in water (20 ml) and a 1 M hydrochloric acid solution (14 ml, 14 mmol, 1.1 eq) is added. The resulting suspension is filtered and the filtrate is concentrated to give 3.4 g of 2-[4-(3- chloropropoxy)phenyl] -4-methyl- 1 ,3 -oxazole-5 -carboxylic acid i43.
  • 2-methylpyrrolidine (0.24 ml, 2.46 mmol, 1.2 eq) is added to a solution of 2-[4-(3- chloropropoxy)phenyl]-N-(cyclopropylmethyl)-4-methyl-N-propyl-l,3-oxazole-5- carboxamide i44 (0.8 g, 2 mmol, 1 eq), potassium carbonate (0.55 g, 4 mmol, 2 eq) and a catalytic quantity of sodium iodide in refluxing acetonitrile (25 ml).
  • the organic layer is dried over magnesium sulfate, filtered and concentrated.
  • the residue is then dissolved in tetrahydrofuran and a 2 N sodium hydroxyde solution is added to reach pH 10.
  • the mixture is refluxed for 40 h and a saturated solution of aqueous ammonium chloride is added and the solution extracted two times with ethyl acetate.
  • the organic layers are dried over magnesium sulfate, filtered and concentrated under vacuum.
  • Methyl ⁇ 2-[4-(2-chloroethoxy)phenyl]-l,3-oxazol-4-yl ⁇ acetate i51 (0.55 g, 1.86 mmol, 1 eq) is reacted with 2-niethylpyrrolidine (0.28 ml, 2.79 mmol, 1.5 eq) in the presence of potassium carbonate (0.77 g, 5.58 mmol, 3 eq) and a catalytic quantity of sodium iodide in refluxing acetonitrile (20 ml). After 45 h, the solvent is evaporated, the residue is then taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate.
  • a 2 N aqueous sodium hydroxide solution (2.6 ml, 5.23 mmol, 6 eq) is added to a solution of methyl (2- ⁇ 4-[2-(2-methylpyrrolidin- 1 -yl)ethoxy]phenyl ⁇ - 1 ,3-oxazol-4- yl)acetate i52 (0.3 g, 0.87 mmol, 1 eq) in ethanol (15 ml). The mixture is stirred at reflux for 3 h and the solvent is then evoporated.
  • N-(3- dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (0.42 g, 2.17 mmol, 2.5 eq) and 1-hydroxybenzotriazole (0.12 g, 0.87 mmol, 1 eq) are then added.
  • the mixture is stirred 24 h at room temperature, and washed two times with a saturated solution of aqueous ammonium chloride.
  • the organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum.
  • a suspension of delta- valerolactani (0.14 g, 1.4 mmol, 1 eq) and sodium hydride (60 % dispersion in mineral oil, 0.056 g, 1.4 mmol, 1 eq) in N,N-dimethylformamide (10 ml) is cooled to 0 0 C and treated with 4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]- 1,3-oxazole ax57 (0.4 g, 1.4 mmol, 1 eq). The mixture is then stirred at room temperature.
  • 2-fluoro-4-(4-piperidin-l-ylmethyl-oxazol-2-yl)-phenol i68 is synthesized according to the following method: a solution of l-( ⁇ 2-[4-(benzyloxy)-3-fluorophenyl]-l,3-oxazol-4- yl ⁇ methyl)piperidine i63 (0.34 g, 0.94 mmol, 1 eq) in ethanol is placed under hydrogen atmosphere (20 psi) at 30 °C for 6 hours.
  • 2-fluoro-4-hydroxybenzoic acid (Ig, 6.41 mmol, 1 eq) is reacted with bromochloropropane (0.82 ml, 8.33 mmol, 1.3 eq) in the presence of potassium carbonate (1.77 g, 12.81 mmol, 2 eq) in methyl ethyl ketone (18 ml) at 80 °C overnight, filtered, washed with acetone and concentrated under vacuum to afford 2 g of 3-chloropropyl 4-(3- chloropropoxy)-2-fluorobenzoate i76.
  • 4-(3-chloropropoxy)-2-methylbenzoyl chloride i81 and 4-(3-chloropropoxy)-3,5- difluorobenzoyl chloride ill3 may be synthesized according to the same method.
  • the residue is purified by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 90:10:0.1) to give 0.10 g of an oil.
  • This oil is taken up in diethyl ether and an excess of methanesulfonic acid (I M solution in diethyl ether) is added.
  • the resulting suspension is filtered and the solid is washed several times with diethyl ether to remove the excess of methanesulfonic acid.

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Abstract

The present invention relates to compounds comprising an oxazole or thiazole moiety of formula (I), processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3 -receptor ligands, Formula (I), wherein , A1 is CH, C(alkyl), C-halogen or N; Rl is hydrogen, halogen, C1-6 alkyl or alkoxy; R2 is, Formula (II’), A3 is O or S; R3 is hydrogen, halogen, C1-6 alkyl or alkoxy; R4 is hydrogen, halogen, C1-6 alkyl, alkoxy or -O-L; R5 is hydrogen or -O-L, wherein L is an aminoalkyl group and at least one of R4 and R5 should be -O-L.

Description

COMPOUNDS COMPRISING AN OXAZOLE OR THIAZOLE MOIETY, PROCESSES FOR MAKING THEM,
AND THEIR USES
The present invention relates to compounds comprising an oxazole or thiazole moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as pharmaceuticals.
The histamine H3 receptor has been known for several years and identified pharmacologically in 1983 by Arrang, J.M. et al. (Nature 1983, 302, 832). Since the cloning of the human histamine H3 receptor in 1999, histamine H3 receptors have been successively cloned by sequence homology from a variety of species, including rat, guinea pig, mouse and monkey.
Histamine H3 -receptor agonists, antagonists and inverse agonists have shown potential therapeutic applications as described in the literature, for example by Stark, H.
(Exp. Opin. Ther. Patents 2003, 13, 851). The histamine H3 receptor is predominantly expressed in the mammalian central nervous system but can also be found in the autonomic nervous system. Evidence has been shown that the histamine H3 receptor displays high constitutive activity, which activity occurs in the absence of endogenous histamine or of a H3 -receptor agonist. Thus, a histamine H3 -receptor antagonist and/or inverse agonist could inhibit this activity. The general pharmacology of histamine H3 -receptor, including H3 -receptor subtypes, has been reviewed by Hancock, A.A (Life Sci. 2003, 73, 3043). The histamine H3 -receptor is not only considered as a presynaptic autoreceptor on histaminergic neurons, but also as a heteroreceptor on non-histaminergic neurons (Barnes, W. et al., Eur. J. Pharmacol. 2001, 431, 215). Indeed, the histamine H3-receptor has been shown to regulate the release of histamine but also of other important neurotransmitters, including acetylcholine, dopamine, serotonin, norepinephrin and γ-aminobutyric acid (GABA).
Thus, the histamine H3 receptor is of current interest for the development of new therapeutics and the literature suggests that novel histamine H3 -receptor antagonists or inverse agonists may be useful for the treatment and prevention of diseases or pathological conditions of the central nervous system including as Mild Cognitive Impairment (MCI), Alzheimer's disease, learning and memory disorders, cognitive disorders, attention deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), Parkinson's disease, schizophrenia, dementia, depression, epilepsy, seizures or convulsions, sleep/wake disorders, narcolepsy, and/or obesity. H3 -receptor ligands alone or in combination with an acetylcholinesterase inhibitor may also be useful in the treatment of cholinergic-deflcit disorders, Mild Cognitive Impairment and Alzheimer's disease as reported by Morisset, S. et al. in Eur. J. Pharmacol.
1996, 315, R1-R2. H3 -receptor ligands, alone or in combination with a histamine H^ -receptor antagonist may be useful for the treatment of upper airway allergic disorders, as reported by
McLeod, R. et al. in J. Pharmacol. Exp. Ther. 2003, 305, 1037.
As described in international patent application WO02/072093, H3-receptor ligands alone or in combination with a muscarinic receptor ligands and particularly with a muscarinic M2~receptor antagonist, may be useful for the treatment of cognitive disorders,
Alzheimer's disease, attention-deficit hyperactivity disorder.
H3 -receptor ligands may also be useful in the treatment of sleep/wake and arousal/vigilance disorders such as hypersomnia, and narcolepsy according to Passani,
M.B.et al. in Trends Pharmacol. Sci. 2004, 25(12), 618-25. In general, H3 -receptor ligands, and particularly H3-receptor antagonists or inverse agonists may be useful in the treatment of all type of cognitive-related disorders as reviewed by Hancock, A.A and Fox, G.B. in Expert Opin, Invest. Drugs 2004, 13, 1237
In particular, histamine H3 -receptor antagonists or inverse agonists may be useful in the treatment of cognitive dysfunctions in diseases such as mild cognitive impairment, dementia, Alzheimer's disease, Parkinson's disease, Down's syndrome as well as in the treatment of attention-deficit hyperactivity disorder (ADHD) as non-psychostimulant agents (see for example Witkin, J.M. et al., Pharmacol. Ther. 2004, 103(1), 1-20.
H3 -receptor antagonists or inverse agonists may also be useful in the treatment of psychotic disorders such as schizophrenia, migraine, eating disorders such as obesity, inflammation, pain, anxiety, stress, depression and cardiovascular disorders, in particular acute myocardial infarction.
There is therefore a need to manufacture new compounds which can potentially act as H3-receptor ligands.
Early literature reports (e.g. AIi, S.M. et al. in J. Med. Chem. 1999, 42, 903 and Drugs Fut. 1996, 21, 507) describe that an imidazole function is essential for high affinity histamine H3-receptor ligands; this is confirmed, for example, by United States patents US
6,506,756B2, US 6,518,287B2, US 6,528,522B2 and US 6,762, 186B2 which relate to substituted imidazole compounds that have H3 receptor antagonist or dual histamine-Hi- receptor and H3 -receptor antagonist activity. International patent application WO 02/12214 describes non-imidazole aryloxyalkylamines useful for the treatment of conditions and disorders mediated by the histamine receptor.
United States patent US 6,436,939B2 relates to H3-receptor antagonists comprising benzoxazole or benzothiazole moieties.
International patent application WO 03/097047 relates to compounds comprising an oxazole moiety for use as melanin concentrating antagonist in the treatment of obesity and diabetes.
International patent application WO 98/27061 describes compounds comprising an oxazole moiety which may be used, for example, for the treatment of hypertension, angina pectoris and diabetic complications.
It has now surprisingly been found that certain compounds comprising an oxazole or thiazole moiety may act as H3 -receptor ligands and therefore may demonstrate therapeutic properties for one or more pathologies that we have described above. Thus, the present invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000004_0001
σ) wherein
A1 is CH, C(alkyl), C-halogen or N;
RMs hydrogen, halogen, C\.β alkyl or alkoxy;
R2 is
Figure imgf000004_0002
(H') A3 is O or S;
R.3 is hydrogen, halogen, C\.β alkyl or alkoxy;
R4 is hydrogen, halogen, C\.β alkyl, alkoxy or -O-L;
R.5 is hydrogen or -O-L; L is C1-6-alkyl amino;
RIO is hydrogen, sulfonyl, amino, C\.β alkyl, C2-6-alkenyl, C2-6-alkynyl, aryl, heteroaryl, C3_g cycloalkyl, 3-8 membered heterocycloalkyl, acyl, C1-6-alkyl aryl, C1-6- alkyl heteroaryl, C2-6-alkenyl aryl, C2-6~alkenyl heteroaryl, C2-6 alkynyl aryl, C2.6 alkynyl heteroaryl, Ci_<5-alkyl cycloalkyl, C1-6-alkyl heterocycloalkyl, C2-6-alkenyl cycloalkyl, C2-6-alkenyl heterocycloalkyl, C2-6-alkynyl cycloalkyl, C2-6~alkynyl heterocycloalkyl, alkoxycarbonyl, aminocarbonyl, C1-6-alkyl carboxy, C1-6-alkyl acyl, C3_g-cycloalkyl acyl, aryl acyl, heteroaryl acyl, C3_g-heterocycloalkyl acyl, C1-6-alkyl acyloxy, C 1.5 -alkyl alkoxy, C1-6-alkyl alkoxycarbonyl, C1-6-alkyl aminocarbonyl, C\.β- alkyl acylamino, acylamino, C1-6-alkyl ureido, C1-6-alkyl carbamate, C1-6-alkyl amino, Cβ.g-cycloalkyl amino, C1-6-alkyl sulfonyl, C1-6-alkyl sulfinyl, C1-6-alkyl sulfanyl, C^_ 6-alkyl sulfonylamino, C1-6-alkyl aminosulfonyl, hydroxy, halogen or cyano;
RH is hydrogen, sulfonyl, amino, C\.β alkyl, C2-6-alkenyl, C2-6-alkynyl, aiyl, heteroaryl, C3_g cycloalkyl, 3-8 membered heterocycloalkyl, acyl, Ci_β-alkyl aryl, C\.β- alkyl heteroaryl, C2-6-alkenyl aryl, C2-6-alkenyl heteroaryl, C2-6 alkynyl aryl, C2-6 alkynyl heteroaryl, C1-6-alkyl cycloalkyl, C1-6-alkyl heterocycloalkyl, C2-6-alkenyl cycloalkyl, C2-6-alkenyl heterocycloalkyl, C2-6-alkynyl cycloalkyl, C2-6-alkynyl heterocycloalkyl, alkoxycarbonyl, aminocarbonyl, C1-6-alkyl carboxy, C1-6-alkyl acyl, C3_g-cycloalkyl acyl, aryl acyl, heteroaryl acyl, C3_g-heterocycloalkyl acyl, C1-6-alkyl acyloxy, C^.β-alkyl alkoxy, C1-6-alkyl alkoxycarbonyl, Ci_5-alkyl aminocarbonyl, C\.β- alkyl acylamino, acylamino, C1-6-alkyl ureido, C1-6-alkyl carbamate, C1-6-alkyl amino, C3_g-cycloalkyl amino, C1-6-alkyl sulfonyl, C1-6-alkyl sulfinyl, C1-6-alkyl sulfanyl, C\_ g-alkyl sulfonylamino, C1-6-alkyl aminosulfonyl, hydroxy, halogen or cyano; and with the proviso that when Rl 1 is an alkoxycarbonyl, R^ is hydrogen, halogen, C^. g alkyl or alkoxy; and with the proviso that R^ is -O-L, when R-> is hydrogen and that R^ is -O-L, when
R4 is hydrogen, halogen, C1-6 alkyl or alkoxy.
The term "alkyl", as used herein, is a group which represents saturated, monovalent hydrocarbon radicals having straight (unbranched), branched or cyclic moieties, or combinations thereof and containing 1-10 carbon atoms, preferably 1-8 carbon atoms; more preferably alkyl groups have 1-6 carbon atoms, most preferably alkyl groups have 1-4 carbon atoms. Preferred alkyl groups, are methyl, ethyl, trifluoromethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 1,3-dimethylbutyl, 3-methylbutyl, n- hexyl, 2-methoxy-l-methylethyl and l-(hydroxymethyl)-3-methylbutyl.
The term "C\_β alkyl" refers to alkyl groups as defined here above having 1 to 6 carbon atoms. This term is exemplified by groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-hexyl, 1,3-dimethylbutyl, 3- methylbutyl and the like. The term "C2-6 alkenyl" refers to alkenyl groups preferably having from 2 to 6 carbon atoms and having at least 1 or 2 sites of alkenyl unsaturation. Preferred alkenyl groups include ethenyl (vinyl, -CH=CH2), n-2-propenyl (allyl, -CH2-CH=CH2) and the like. The term "C2-6-alkynyl" refers to alkynyl groups preferably having from 2 to 6 carbon atoms and having at least 1 to 2 sites of alkynyl unsaturation. Preferred alkynyl groups include ethynyl (-C=CH), propargyl (-CH2CH=CH), and the like.
The term "C3_3 cycloalkyl", as used herein, is a monovalent group of 3 to 8 carbon atoms usually 3 to 6 carbon atoms derived from an unsaturated or saturated monocyclic or bicyclic hydrocarbon. Preferred cycloalkyl are cyclopropyl, cyclopentyl, 3,4- dimethylcyclopentyl and cyclohexyl. The term "C1-6-alkyl cycloalkyl", as used herein, refers to a C1-6 alkyl having a cycloalkyl substituted. Examples include cyclopropylmethyl and the like.
The term "C2-6"a^enyl cycloalkyl", as used herein, refers to a C2-6 alkenyl having a cycloalkyl substitutent.
The term "C2-6-alkynyl cycloalkyl", as used herein, refers to a C2-6 alkynyl having a cycloalkyl substitutent.
The term "heteroatom" as used herein represents a nitrogen, oxygen or sulfur atom. The term "halogen", as used herein, represents an atom of fluorine, chlorine, bromine, or iodine.
The term "hydroxy", as used herein, represents a group of formula -OH. The term "heterocycloalkyl" refers to a C3-8 cycloalkyl group according to the definition here above, in which 1 to 3 carbon atoms are replaced by heteroatoms chosen from the group consisting of O, S, N.
Each carbon of the heterocycloalkyl may be unsubstituted or substituted by one or more C 1.4 alkyl, C3-8 -cycloalkyl, C1-6-alkyl aryl or halogen as defined herein. Examples of such heterocycloalkyls are pyrrolidine, piperidine, piperazine, morpholine, 2- methylpyrrolidine, (2S)-2-methylpyrrolidine, (2R)-2-methylpyrrolidine, 4-methylpyridine, 2-methylpiperidine, 2,6-dimethylpiperidine, 4-methylpiperidine, 4-benzylpiperidine, 4- isopropylpiperazine, 3,5-dimethylpiperidine, 2-isobutylpyrrolidine, 4,4-difluoropiperidine, 2-ethylpyrrolidine, 4-cyclopentylpiperazine, 4-(2-pyrrolidin-l-ylethyl)piperazine, azepane,
2-azaspiro[5.5]undecane and 7,8-dimethyl-l-azaspiro[4.4]nonane. The heterocycloalkyl may also be fused with a C3_g cycloalkyl to form a bicyclic heterocycloalkyl. Examples include (4aR,8aS)-decahydroisoquinoline and the like.
One carbon of the heterocycloalkyl may be replaced by a carbonyl and/or substituted by an amino group or a heterocycloalkyl or C \ _g alkyl heterocycloalkyl as defined herein. Examples of such heterocycloalkyl are 2-oxopyrrolidine, 2-oxopiperidine, (5S)-2-oxo-5-(pyrrolidin- 1 -ylmethyl)pyrrolidine, 3-(dimethylamino)pyrrolidhie, (2S)-2- (pyrrolidin-l-ylmethyl)pyrrolidine, 2-(pyrrolidin-l-ylmethyl)pyrrolidine and (2S)-2-
(4moφholin- 1 -ylmethyl)pyrrolidine. The term "C1-6-alkyl heterocycloalkyl", as used herein, refers to a C1-6 alkyl having a heterocycloalkyl as defined hereabove as substitutent.
The term "C2-6-alkenyl heterocycloalkyl", as used herein, refers to a Co.β alkenyl having a heterocycloalkyl as defined here above as substitutent.
The term "C2-6-alkynyl heterocycloalkyl", as used herein, refers to a C2-6 alkynyl having a heterocycloalkyl as defined here above as substitutent.
The term "amino group", as used herein, represents a group of formula - NR^RC wherein R^ and Rc are independently hydrogen, "C1-6 alkyl", "C2-6 alkenyl", "C2-6 alkynyl", "C3_8 cycloalkyl", "heterocycloalkyl", "aryl", "heteroaryl", "C1-6-alkyl aryl", "C1-6-alkyl heteroaryl", "C2-6-alkenyl aryl", "C2-6-alkenyl heteroaryl", "C2-6-alkynyl aryl", "C2-6-alkynylheteroaryl", "C 1 _6-alkyl cycloalkyl" or "C 1 _6-alkyl heterocycloalkyl" groups; or R^ and Rc are linked together with N to form a 3 to 8 membered heterocycloalkyl ring.
Preferred "amnio groups" are hexyl(methyl)amino, benzyl(methyl)amino, (2- methoxy-l-methylethyl)amino, [l-(hydroxymethyl)-3-methylbutyl]amino, cyclopentylamino, (l,3-dimethylbutyl)amino, (cyclopropylmethyl)(propyl)amino, (2- furylmethyl)(methyl)amino, sec-butyl(propyl)amino, benzylamino, (4aR, 8aS)- octahydroisoquinolin-2-(lH)-yl, (4-chlorobenzyl)amino, (3-methoxyphenyl)amino, (2S)-2- (morpholin-4-ylmethyl)pyrrolidiii- 1 -yl, (2-methyl-2H-tetrazol-5-yl)amino, anilino, (pyridin-3-yl)amino, (4-fluorobenzyl)amino, (4-fluorophenyl)amino, 1-pyrrolidinyl, 1- piperidinyl, 1-piperazinyl, 4-morpholinyϊ, 1-azepanyl, 2-methylpyrrolidin-l-yl, (2S)-2- methylpyrrolidin-1-yl, (2R)-2-methylpyrrolidin-l-yl, 2-methylpiperidin-l-yl, 2,6- dimethylpiperidin-1-yl, 4-methylpiperidin-l-yl, 4-benzylpiperidin-l-yl, 4- isopropylpiperazin-1-yl, 3,5-dimethylpiperidin-l-yl, 2-isobutylpyrrolidin-l-yl, 4,4- difluoropiperidin- 1 -yl, 2-ethylpyrrolidin- 1 -yl, 2-oxopyrrolidin- 1 -yl, 2-oxopiperidin- 1 -yl, (5 S)-2-oxo-5-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl), 3-(dimethylamino)pyrrolidin- 1 -yl, (2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl, 2-(pyrrolidin- 1 -ylmetbyl)pyrrolidin~ 1 -yl, 2- azaspiro[5.5]undec-2-yl, 7,8-dimethyl-lazaspiro[4.4]non-l-yl, 4-cyclopentylpiperazin-l-yl (4aR, 8aS)-octahydroisoquinolin-2( 1 H)-yl and 4-(2-pyrrolidin- 1 -ylethyl)piperazin- 1 -yl. The term "aminocarbonyl" as used herein refers to a group of formula -C(O)N
RbRC wherein R^ and Rc are as defined here above for the amino group. Preferably R^ and Rc together do not form a guanidine group. Preferred aminocarbonyl groups include [(cyclopropylmethyl)(propyl)amino]carbonyl, (cyclopentylamino)carbonyl, (benzylamino)carbonyl, [(4-fluoro)benzylaminocarbonyl, [(4- fluoro)phenyl)amino] carbonyl, pyrrolidin- 1 -ylcarbonyl, piperidin- 1 -ylcarbonyl, 4,4- difluoropiperidin- 1 -ylcarbonyl, (2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -ylcarbonyl, azepan-1 -ylcarbonyl are morpholin-4-ylcarbonyl and (4-cyclopentylpiperazin-l- yl)carbonyl.
The term "Cj. β alkyl aminocarbonyl" as used herein, refers to a C1-6 alkyl susbtituted by an aminocarbonyl as defined hereabove.
The term "a C\.β alkyl amino", as used herein, represents a C\_β alkyl group substituted by an amino group as defined above. Preferred C1-6 alkyl amino groups include 2-pyrrolidin-l-ylethyl, pyrrolidin- lylmethyl, piperidin- 1-ylmethyl, azepan-1 -ylmethyl, (2- methylpyrrolidm- 1 -yl)methyl, (2-methylpiperidinl -yl)methyl, (2,6-dimethylpiperidin- 1 - ylmethyl), (4-methylpiperidin-l-yl)methyl, 4-benzylpiperidin- 1-ylmethyl, 4- isopropylpiperazin- 1 -ylmethyl, 3 ,5 -dimethylpiperidin- 1 -ylmethyl, 2-isobutylpyrrolidin- 1 - ylmethyl, (4-cyclopentylpiperazin-l-yl)methyl, (4,4-difluoro)piperidin-l-yl methyl, 2- ethylpyrrolidin- 1 -ylmethyl, (2-azaspiro[5.5]undec-2-yl)methyl, (7,8-dimethyl- 1 - azaspiro[4.4]non- 1 -yl)methyl, 2-oxopyrrolidin-l -yhnethyl, 2-oxopiperidin- 1 -yhnethyl, [(5S)-2-oxo-5-(pyrrolidin-l-ylmethyl)pyrrolidin-l-yl]methyl, (4aR,8aS)- octahydroisoquinolin-2(l H)-yhnethyl, moφholin-4-ylmethyl, [(2S)-2-(morpholin-4- ylmethyl)pyrrolidin- 1 -yl]methyl, 3 -piperidin- 1 -ylpropyl, 3 -(2-methylpiperidin- 1 -yl)propyl, 3 -(4-methylpiperidin- 1 -yl)propyl, 3 -pyrrolidin- 1 -ylpropyl, 3 -(2-methylpyrrolidin- 1 - yl)propyl, 3 -((2R)-2-methylpyrrolidin- 1 -yl)propyl, 3-((2S)-2-methylpyrrolidin- 1 -yl)propyl, 3-(4-isopropylpiperazin- 1 -yl)propyl, 3-[2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yljpropyl, 3- [(2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl]propyl, 3 -(2-isobutylpyrrolidin- 1 -yl)propyl, 3-(2-ethylpyrrolidin-l -yl)propyl, 3-[(4aR,8aS)-octahydroisoquinolin-2(lH)-yl]propyl, 3-(4- cyclopentylpiperazin-l-yl)propyl, 3-azepan-l-ylpropyl, 2-piperidin-l-ylethyl, 2-(2- methylpiperidin-l-yl)ethyl, 2-azepan-l-ylethyl, 2-[4-(2-pyrrolidin-l-ylethyl)piperazin-l- yl]ethyl, 4-(2-methylpiperidin-l-yl)butyl, 4-[3-(dimethylamino)pyrrolidin-l-yl]butyl, 4- azepan-1-ylbutyl, [hexyl(methyl)amino]methyl, [benzyl(methyl)amino]methyl, [(2- methoxy-l-methylethyl)amino]methyl, anilinomethyl, {[l-(hydroxymethyl)-3- methylbutyl]amino}methyl, (cyclopentylamino)methyl, [(l,3-dimethylbutyl)amino]methyl, [(2-methyl-2H-tetrazol-5-yl)amino]methyl, [(cyclopropylmethyl)(propyl)amino]methyl, [(2-furylmethyl)(methyl)amino]methyl, [sec-butyl(propyl)amino]methyl, (benzylamino)methyl, [(4-chlorobenzyl)amino]methyl, [(3 -methoxyphenyl)amino]metliyl, [(4-fluorophenyl)amino]methyl, (pyridin-3-ylamino)methyl, 3-(2,6-dimethyl-piperidin-l- yl)propyl and 2-(2-methylpyrrolidin-l-yl)ethyl. The term "C3_g-cycloalkyl amino", as used herein, represents a C3_g cycloalkyl group substituted by an amino group as defined above.
The term "acylamino", as used herein refers to a group of formula -NR^C(O)RC wherein R^ and Rc are as defined hereabove for the amino group.
The term "C1-6-alkyl acylamino", as used herein refers to a C^. β alkyl substituted by an acylamino as defined hereabove.
The term "alkylene", as used herein, represents a group of formula -(CE^)x- in which x is comprised between 1 and 10, preferably comprised between 2 and 8, more preferably comprised between 2 and 6.
The term "methylene" as used herein represents a group of formula -CH2-. The term "aryl" as used herein, refers to an unsaturated aromatic carbocyclic group of from 6 to 14 carbon atoms having a single ring (e.g., phenyl) or multiple condensed rings (e.g., naphthyl). Preferred aryl include phenyl, 4-fluorophenyl, 4-chlorophenyl, 3- methoxyphenyl, naphthyl, phenantrenyl and the like.
The term "C1-6-alkyl aryl", as used herein, refers to a group of formula -R"-aryl in which R" is a C1-6 alkyl. Preferred "C1-6-alkyl aryl" are benzyl, 4-fluorobenzyl and A- chlorobenzyl.
The term "C2-6-alkenyl aryl", as used herein, refers to a C2-6 alkenyl having an aryl substitutent. The term "C2-6~alkynyl aryl", as used herein, refers to a C2-6 alkynyl having an aryl substitutent.
The term "heteroaryl" as used herein represents an aryl group as defined here above wherein one or more of the carbon atoms have been replaced by a heteroatom as defined herein. Particular examples of heteroaromatic groups include optionally substituted pyridyl, pyrrolyl, furyl, thienyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadia-zolyl, 1,2,5-oxadiazolyl, l,3,4-oxadiazolyl,l,3,4-triazinyl, 1,2,3-triazinyl, benzofuryl, [2,3-dihydro]benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, isobenzothienyl, indolyl, isoindolyl, 3H- indolyl, benzimidazolyl, imidazo[l,2-a]pyridyl, benzothiazolyl, benzoxa-zolyl, quinolizinyl, quinazolinyl, pthalazinyl, quinoxalinyl, cinnolinyl, napthyridinyl, pyrido[3,4- b]pyridyl, pyrido[3,2~b]pyridyl, pyrido[4,3-b]pyridyl, quinolyl, isoquinolyl, tetrazolyl, 5,6,7,8-tetrahydroquinolyl, 5,6,7,8-tetrahydroisoquinolyl, purinyl, pteridinyl, carbazolyl, xanthenyl or benzoquinolyl. Preferred heteroaryls are 2H-tetrazolyl, furyl and pyridinyl. The term "C1-6-alkyl heteroaryl" refers to a C \.5 alkyl having a heteroaryl substituent as defined hereabove. Examples include 2-furylmethyl, (2-methyl-lH-imidazol- lyl)methyl and (lH-l,2,4-triazol-l-yl)methyl.
The term "C2-6-alkenyl heteroaryl", as used herein, refers to a C2-6 alkenyl having a heteroaryl substitutent. The term "C2-6-alkynyl heteroaryl", as used herein, refers to a C2-6 alkynyl having a heteroaryl substitutent.
The term "alkoxy", as used herein, represents a group of formula -ORa wherein Ra is "Ci.6 alkyl", "C2-6 alkenyl", "C2-6 alkynyl", "C3_8 cycloalkyl", "heterocycloalkyl", "aryl", "heteroaryl", "C^-alkyl aryl" or "Ci_6-alkyl heteroaryl", "C2_6-alkenyl aryl", "C2-6-alkenyl heteroaryl", "C2-6-alkynyl aryl", "C2-6-alkynyl heteroaryl", "Ci.g-alkyl cycloalkyl" or "C1-6-alkyl heterocycloalkyl". Preferred alkoxy group is methoxy.
The term "C1-6-alkyl alkoxy" as used herein refers to a C1-6-alkyl substituted by an alkoxy as defined here above.
The term "carbonyl", as used herein represents a group of formula C=O. The term "C1-6-alkyl carboxy", as used herein refers to a C1-6-alkyl susbtituted by a carboxy group including 2-carboxyethyl and the like.
The term "acyl" as used herein, refers to the group -C(O)Re wherein Re includes H, "C1-6 alkyl", "C2_6 alkenyl", "C2_6 alkynyl", "C3_g cycloalkyl", "heterocycloalkyl", "aryl", "heteroaryl", "C^-alkyl aryl" or "Ci_6-alkyl heteroaryl", "C2_6-alkenyl aryl", "C2-6-alkenyl heteroaryl", "C2-6-alkynyl aryl", "C2-6-alkynylheteroaryl", "C1-6-alkyl cycloalkyl" and "C1-6-alkyl heterocycloalkyl".
The term "C1-6_alkyl acyl" as used herein refers to a C\. g alkyl having an acyl substituent as defined here above, including 2-acetylethyl and the like. The term "C3_8-cycloalkyl acyl" as used herein refers to a C3_g alkyl having an acyl substituent as defined here above.
The term "aryl acyl" refers to an aryl group having an acyl substituent as defined here above.
The term "heteroaryl acyl" refers to a heteroaryl group having an acyl substituent as defined here above.
The term "heterocycloalkyl acyl" refers to a heterocycloalkyl group having an acyl substituent as defined here above.
The term "acyloxy" refers to the group -OC(O)Rf wherein R^ includes H, "C1-6 alkyl", "C2_6 alkenyl", "C2_6 alkynyl", "C3.8 cycloalkyl", "heterocycloalkyl", "heteroaryl", "C1-6-alkyl aryl", "Ci_6-alkyl heteroaryl", "C2-6-alkenyl aryl", "C2_6- alkenyl heteroaryl", "C2_6-alkynyl aryl", "C2_6-alkynyl heteroaryl", "C2_g-alkyl cycloalkyl" or "C \ _6-alkyl heterocycloalkyl".
The term "Ci.β-alkyl acyloxy" refers to a C\_ β alkyl having an acyloxy as defined here above as substituent. The term "alkoxycarbonyl" refers to the group -C(O)ORg wherein RS includes H,
"C1-6 alkyl", "C2.6 alkenyl", "C2.6 alkynyl", "C3.8 cycloalkyl", "heterocycloalkyl", "aryl", "heteroaryl", "Ci_6-alkyl aryl" or "Ci.g-alkyl heteroaryl", "C2_6-alkenyl aryl", "C2-6-alkenyl heteroaryl", "C2_6-alkynyl aryl", "C2_6-alkynylheteroaryr, "C2_6-alkyl cycloalkyl", "C1-6-alkyl heterocycloalkyl". Preferred alkoxycarbonyl are methoxycarbonyl, ethoxycarbonyl and hydroxycarbonyl.
The term "C1-6-alkyl alkoxycarbonyl" refers to a refers to a C\^ alkyl having a alkoxycarbonyl as defined here above as substituent.
The term "ureido" as used herein refers to a group of formula -NR1C(O)NR^R0 wherein R* is as defined hereabove for R^ or Rc, and R^ and Rc are as defined here above for the amino group.
The term "C1-6-alkyl ureido" as used herein refers to a C1-6 alkyl substituted by a ureido as defined here above.
The term "carbamate", as used herein, refers to a group of formula— NR^C(O)OR0 whrein R^ and Rc are as defined here above for the amino group. The term "C1-6-alkyl carbamate" as used herein refers to a C1-6-alkyl substituted by a carbamate as defined here above.
The term "sulfonyl" refers to group of formula "-SO2-Rh" wherein Rn is selected from H, "aryl", "heteroaryl", uC\.β alkyl", "C\.β alkyl" substituted with halogens, e.g., an -SO2-CF3 group, "C2_6 alkenyl", "C2_6 alkynyl", "C3_8 cycloalkyl", "heterocycloalkyl", "aryl", "heteroaryl", "C1-6-alkyl aryl" or "C1-6-alkyl heteroaryl", "C2_6-alkenyl aryl", "C2_g-alkenyl heteroaryl", "C2_6-alkynyl aryl", "C2.g alkynyl heteroaryl", "C1-6-alkyl cycloalkyl", "C1-6-alkyl heterocycloalkyl".
The term "sulfinyl" refers to group of formula "-S(O)-RJ" wherein RJ is selected from H, "aryl", "heteroaryl", "C1-6 alkyl", "Q .5 alkyl" substituted with halogens, e.g., an -SO-CF3 group, "C2_6 alkenyl", "C2_6 alkynyl", "C3.8 cycloalkyl", "heterocycloalkyl", "aryl", "heteroaryl", "Ci_6-alkyl aryl" or "Ci_6-alkyl heteroaryl", "C2.6-alkenyl aryl", "C2_6-alkenyl heteroaryl", "C2_6-alkynyl aryl","C2_6-alkynyl heteroaryl","C1-6-alkyl cycloalkyl", "C1-6-alkyl heterocycloalkyl". The term "sulfanyl" refers to group of formula "-S-R^" wherein R^ is selected from
H, "aryl", "heteroaryl", "C\.β alkyl", "Cj.6 alkyl" substituted with halogens, e.g., an -S- CF3 group, "C2.6 alkenyl", "C2.6 alkynyl", "C3.8 cycloalkyl", "heterocycloalkyl", "aryl", "heteroaryl", "C1-6-alkyl aryl" or "C1-6-alkyl heteroaryl", "C2.6-alkenyl aryl", "C2_6- alkenyl heteroaryl", "C2_6-alkynyl aryl", "C2_6-alkynyl heteroaryl", "C1-6-alkyl cycloalkyl", "C 1 _6-alkyl heterocycloalkyl".
The term "Ci_g-alkyl sulfonyl" refers to C1-6-alkyl groups having a sulfonyl substituent, including 2-(methylsulfonyl)ethyl and the like.
The term "C1-6-alkyl sulfinyl" refers to Ci_5~alkyl groups having a sulfinyl as defined here above as susbtituent, including 2-(methylsulfinyl)ethyl and the like. The term "C1-6-alkyl sulfanyl" refers to Ci.β-alkyl groups having a sulfanyl as defined here above substituent.
The term "sulfonylamino" as used herein refers to a group of formula -NRt>so2-Rc wherein R^ and Rc are as defined here above for the amino group.
The term "C1-6-alkyl sulfonylamino" refers to C1-6-alkyl groups having a sulfonylamino as defined here above as substituent.
The term "aminosulfonyl" as used herein refers to a group of formula -SO2-NR^R0 wherein R^ and Rc are as defined here above for the amino group.
The term "C1-6-alkyl aminosulfonyl" refers to C1-6-alkyl groups having an aminosulfonyl as defined here above as substituent. The term "ester", as used herein represents a group of formula -COORe, in which Re is a Cj .4 alkyl.
The term "carboxylic acid" as used herein represents a group of formula -COOH.
Unless otherwise constrained by the definition of the individual substituent, the above set out groups including "alkyl", "alkenyl", "alkynyl", "aryl" and "heteroaryl" and the like can optionally be substituted with from 1 to 5 substituents selected from the group consisting of "C1-6 alkyl", " C2_6 alkenyl", "C2_6 alkynyl", "C3_8 cycloalkyl", "heterocycloalkyl", "Cμ6-alkyl aryl", "C1-6-alkyl heteroaryl", "Ci_6-alkyl cycloalkyl", "C1-6-alkyl heterocycloalkyl", "amino", "acyl", "acyloxy", "acylamino", "aminocarbonyl", "alkoxycarbonyl", "ureido", "carbamate", "aryl", "heteroaryl", "sulfmyl", "sulfonyl", "alkoxy", "sulfanyl", "halogen", "carboxylic acid", trihalomethyl, cyano, hydroxy, mercapto, nitro, alkylene and the like.
In a particular embodiment, the C1-6 alkyl of L is not substituted by a hydroxy group. In a further particular embodiment when R^ is a C \ _g alkyl, said alkyl is unsubstiruted.
In a particular embodiment of compounds of formula (I), R^ is hydrogen and R^ is- O-L.
Generally, the present invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000013_0001
(I)
wherein
A1 is CH, C(CH3), C-halogen or N;
RI is hydrogen or halogen; R2 is
Figure imgf000014_0001
(π1) ;
A3 is O or S;
R3 is hydrogen, halogen, C 1.4 alkyl or C 1.4 alkoxy; R4 is hydrogen, halogen, C1.4 alkyl, C1.4 alkoxy or -O-(CH2)n-NR12aR12b;
R5 is hydrogen or -O-(CH2)m-NR13aR13b; R10 is hydrogen, Ci_g alkyl or -(CH2)w-(C=O)t-NR15R16; Rl 1 is hydrogen, C^.g alkyl, ester, carboxylic acid, halogen, or -(CH2)r-(C=O)z- NR17R18; Rl2a and Rl2b ^6 linked together to form a Cβ.g alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl;
R^3a and R^3b are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C \j[ alkyl, an amino group or a C\. β alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Cj_g alkyl, C3.fi cycloalkyl or C1-6 alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C3.6 alkylene;
R!5 is hydrogen or a C^.g alkyl;
R!6 is aryl, heteroaryl, Cj.g alkyl, C1-6 alkyl cycloalkyl, C3..6 cycloalkyl, C\.β alkyl aryl or CH2-heteroaryl; or R!5 and R^ are linked together to form a C3_g alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by an C\_ 5 alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or a C3_g cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3_g cycloalkyl or a carbonyl and another methylene being optionally substituted by an alkylamine; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C^-β alkylene; or R^ and Rl 6 are linked together to form with N an unsaturated 5- or 6-membered heteroaryl optionally substituted by a Cj .4 alkyl;
R!7 is hydrogen or a C\_ g alkyl;
R!8 is Cj.g alkyl, C\.β alkyl aryl or C\.β alkyl cycloalkyl; or Rl^ and R^ are linked together to form a C^-Q alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C3.6 cycloalkyl; n and m are independently an integer comprised between 2 and 8; w and r are independentely an integer comprised between 0 and 4; t and z are independentely an integer equal to 0 or 1; with the proviso that R4 is -O-(CH2)n-NR 12aR12b, when R5 is hydrogen and that
R5 is -O-(CH2)m-NR13aR13b, when R4 is hydrogen, halogen, Cμ4 alkyl or Ci_4 alkoxy; with the proviso that when Rl 1 is an ester or a carboxylic acid, R4 is hydrogen, halogen, C 1.4 alkyl or C \.4 alkoxy; with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0.
Usually each CH2 in -O-(CH2)n-NR12aR12b or -0-(CH2)J11-NR13aR13b may be unsusbstituted or substituted by one or more C 1.4 alkyl. Usually, A1 is CH, C(CH3), C-F or N.
More preferably A^ is CH, C-F or N. Most preferably, A^ is CH or C-F. In a particular embodiment Al is CH. Usually, A3 is O or S. In a particular embodiment A3 is O. hi another particular embodiment A3 is S.
Usually in an embodiment, Rl is hydrogen or fluorine.
Preferably, Rl is hydrogen.
Usually in one embodiment, R3 is hydrogen, halogen or C\_ 4 alkyl. Usually, in another embodiment, R3 is hydrogen, fluorine, methyl or methoxy.
Preferably, R3 is hydrogen or fluorine or methyl. Most preferably, R3 is hydrogen or methyl. Usually, in one embodiment, R.4 is hydrogen, halogen, C\ .4 alkyl, C \ „4 alkoxy, or - O-(CH2)n-NRl2aRl2b, Usually, in another embodiment, R^ is hydrogen, bromine, fluorine, chlorine, methyl, methoxy, trifluoromethyl or -O-(CH2)n-NRl2aRl2b each CH2 in -O~(CH2)n-NRl2aRl2b being optionally substituted by one or two methyl. Preferably, R4 is hydrogen, chlorine, bromine, fluorine, methyl, methoxy or -O-(CH2)n-NRl2aRl2b
More preferably, R^ is hydrogen, chlorine, bromine, fluorine or methoxy. Most preferably, R4 is hydrogen or fluorine.
Preferably, -NR12aR12b is 1-ρyrrolidinyl.
Usually, n is comprised between 2 and 4. Preferably, n is equal to 3. Usually in one embodiment, R^ is hydrogen or -O-(CH2)m-NRl3aRl3b Usually in another embodiment, R5 is hydrogen or -O-(CH2)m-NR13aR13b, each CH2 in -O- (CH2)m-NRl3aRl3b being optionally substituted by one or two methyl.
Preferably, R5 is hydrogen or -O-(CH2)m-NR13aR13b. More preferably, R5 is -O- (CH2)m-NR13aR13b. Preferably, -NRl3aRl3b is selected from the group consisting of 1-piperidinyl, 1- pyrrolidinyl, 2-methylpyrrolidin-l-yl, (2S)-2-methylpyrrolidin-l-yl, (2R)-2- methylpyrrolidin-1-yl, 4-isopropylpiperazin-l-yi, 4-methylpiperidin-l-yl, 2- methylpiperidin- 1 -yl, 2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl, 4-cyclopentylpiperazin- 1 - yl, 3-(dimethylamino)pyrrolidin-l-yl, 4-(2-pyrrolidin-l-ylethyl)piperazin-l-yl, 1-azepanyl, 2,6-dimethylpiperidin-l-yl, (2S)-2-(pyrrolidin-l-ylmethyl)pyrrolidin-l-yl, 2- isobutylpyrrolidin-1-yl, 2-ethylpyrrolidinyl or (4aR, 8aS)-octahydroisoquinolin-2-(lH)-yl.
Most preferably, -NR*3aRl3b is selected from the group consisting of 1- piperidinyl, 2-methylpyrrolidin-l-yl, (2S)-2-methylpyrrolidin-l-yl, (2R)-2- methylpyrrolidin-1-yl, 4-methylpiperidin-l-yl, 2-methylpiperidin-l-yl, 2-(pyrrolidin-l- ylmethyl)pyrrolidin-l-yl, (2S)-2-(pyrrolidin-l-ylmethyl)pyrrolidin-l-yl, 2- isobutylpyrrolidin-1-yl, 2-ethylpyrrolidin-l-yl, (4aR, 8aS)-octahydroisoquinolin-2-(lH)-yl, 1-azepanyl, and 2,6-dimethylpiperidin-l-yl.
In a particular embodiment, -NRl3aRl3b is 2-methylpyrrolidin-l-yl, (2S)-2- methylpyrrolidin-1-yl or (2R)-2-methylpyrrolidin-l-yl. Usually, m is comprised between 2 and 5. Preferably, m is comprised between 2 and
4. Most preferably, m is equal to 3 or 4. In a particular embodiment, m is equal to 3. Preferably, R10 is hydrogen, methyl or -(CH2)w-(C=O)t-NR15R16. Most preferably, R10 is methyl or -(CH2)w-(C=O)t-NR15R16. In a particular embodiment, RlO is methyl.
Preferably -NRl ^R 16 [s selected from the group consisting of 1-piperidinyl, 2- methylpyrrolidin-1-yl, 1-pyrrolidinyl, 1-azepanyl, 4-methylpiperidin-l-yl, 2- methylpiperidin- 1 -yl, (3 ,5-dimethyl)piperidin- 1 -yl, hexyl(methyl)amino, benzyl(methyl)amino, (2-methoxy-l-methylethyl)amino, 2-azaspiro[5.5]undec-2-yl, 7,8- dimethyl-lazaspiro[4.4]non-l-yl, 2-oxopyrrolidin-l-yl, anilino, 2-methyl-lH-imidazol-l-yl, lH-l,2,4-triazol-l-yl, [l-(hydroxymethyl)-3-methylbutyl]amino, cyclopentylamino, (1,3- dimethylbutyl)amino, (cyclopropylmethyl)(propyl)amino, 2,6-dimethylpiperidin-l-yl, (2- furylmethyl)(methyl)amino, sec-butyl(propyl)amino, 4-benzylpiperidine-l-yl, A- cyclopentylpiperazin-1-yl, 4-moφholin-l-yl, (4-fluorobenzyl)amino, (4- chlorobenzyl)amino, 2-oxo-piperidin- 1 -yl, (5 S)-2-oxo-(5-pyrrolidin- 1 -ylmethyl)pyrrolidin- 1-yl, (4-fluorophenyll)amino, (4aR, 8aS)octahydroisoquinoline-2-(lH)-yl, (2S)-2- (pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl, (2-methyl-2H-tetrazol-5 -yl)amino, (3 - methoxyphenyl)amino, (pyridin-3-yl)amino, (2S)-2-(morpholin-4-ylmethyl)pyrrolidin-l-yl, (2S)-2-(moφholin-4-ylmethyl)-5-oxopyrrolidin-l-yl, benzylamino and 4,4- difluoropiperidin- 1 ~yl.
More preferably -NRl ^RI 6 js selected from the group consisting of 1-piperidinyl, 2-methylpyrrolidin-l-yl, 1-pyrrolidinyl, 1-azepanyl, 2-methylpiperidin-l-yl, (3,5- dimethyl)piperidin-l-yl, hexyl(methyl)amino, benzyl(methyl)amino, 2-azaspiro[5.5]undec- 2-yl, 7,8-dimethyl-lazaspiro[4.4]non-l-yl, 2-oxopyrrolidin-l-yl, anilino, 2-methyl-lH- imidazol- 1 -yl, IH-1 ,2,4-triazol- 1 -yl, [ 1 -(hydroxymethyl)-3 -methylbutyl]amino, cyclopentylamino, (l,3-dimethylbutyl)amino, (cyclopropylmethyl)(propyl)amino, 2,6- dimethylpiperidin-l-yl, (2-furyhnethyl)(methyl)amino, sec-butyl(propyl)amin, A- benzylpiperidin-1-yl, 4-cyclopentylpiperazin-l-yl, 4-moφholinyl, (4-fluorobenzyl)amino, (4-chlorobenzyl)amino, 2-oxo-piperidin- 1-yl, (5S)-2-oxo-5-pyrrolidin-l-yl, (A- fluorophenyl)amino, (4aR, 8aS)-octahydroisoquinolin-2(lH)-yl, (2S)-2-(pyrrolidin-l- ylmethyl)pyrrolidin-l-yl, (3-methoxyphenyl)amino, (pyridin-3-yl)amino, benzylamino and 4,4-difluoropiperidin- 1 -yl; Most preferably, -NRl^Rl^ is selected from the group consisting of 1-piperidinyl,
1-pyrrolidinyl, 2-methylpyrrolidin-l-yl, 7,8-dimethyl-lazaspiro[4.4]non-l-yl, 1H-1,2,4- triazol- 1 -yl, [ 1 -(hydroxymethyl)-3 -methylbutyl]amino, 2,6-dimethylpiperidin- 1 -yl, benzylamino, sec-butyl(propyl)amino, (4aR, 8aS)-octahydroisoquinolin-2(lH)-yl and (2S)- 2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl. In a particular embodiment according to the present invention, -NR^R^ is 1-piperidinyl.
Preferably, w is an integer equal to 0, 1 or 2. In a particular embodiment w is equal to l.
In a particular embodiment, t is an integer equal to 0. In another particular embodiment, t is an integer equal to 1.
Preferably, R11 is hydrogen, methyl, COOCH3, COOH, bromine or -(CH2)r-
(C=O)2-NR17R18. More preferably, R11 is hydrogen, methyl, COOCH3, bromine or - (CH2V(C=O)2-NR17R18. Most preferably, R1 ! is hydrogen, COOCH3, bromine or - (CH2)r-(C=O)z- NR17R18. In a particular embodiment acording to the present invention, R11 is H or -(CH2V(C=O)2-NR17R18.
Preferably, -NR17R18 is 1-piperidinyl, 2-oxopyrrolidin-l-yl, (cyclopropylmethyl)(propyl)amino, cyclopentylamino, benzylamino, (4- cyclopentyl)piperazin-l-yl, 4-morpholinyl or 4,4-difluoropiperidin-l-yl.
In a particular embodiment according to the present invention, -NR17R18 is 4- morpholinyl or 4,4-difluoropiperidin- 1 -yl.
Preferably, z is equal to 0 or 1. In a particular embodiment z is equal to 0. In another particular embodiment z is equal to 1.
Preferably, r is an integer equal to 0, 1 or 2. In a particular embodiment r is an integer equal to 0. Preferably, when R1 ° is -(CH2)W-(C=O)1-NR15R16, R11 is hydrogen, methyl,
COOCH3, COOH or bromine. In a particular embodiment according to the present invention when R10 is -(CH2)w-(C=O)t-NR15R16, R1 * is hydrogen.
Combinations of one or more of these preferred groups are especially preferred.
Usually in one embodiment, the present invention relates to compounds of formula
(I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000018_0001
0) wherein
A1 is CH, C(CH3), C-halogen or N;
RI is hydrogen; R2 is
Figure imgf000019_0001
(H1)
A3 is O or S;
R3 is hydrogen, halogen or C\ .4 alkyl;
R4 is hydrogen, halogen, C1.4 alkyl, C1.4 alkoxy or -0-(CH2V-NR 12aR12b R5 is hydrogen or -O-(CH2)m-NR13aR13b;
R10 is hydrogen, Cμg alkyl or -(CH2)w-(C=O)t-NR15R16; RI 1 is hydrogen, C\.$ alkyl, ester, carboxylic acid, halogen, or -(CH2V(C=O)2- NR17R18;
R*2a and Rl2b are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C\ .4 alkyl;
Rl3a an(j Rl3b aj-g linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl, an amino group or an C1-6 alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a C\_ 8 alkyl, C^-β cycloalkyl or C\.β alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C^-β alkylene;
R15 is hydrogen or a Cj.g alkyl;
R!6 is aryl, heteroaryl, Cj.g alkyl, Cβ.g cycloalkyl, C1-6 alkyl cycloalkyl, Cj.6 alkyl aryl or a CH2~heteroaryl; or R.15 and R^ are linked together to form a C^s alkylene, each methylene of the alkylene being optionally substituted by one or two C \.4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by an C1-6 alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C3_β cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3_g cycloalkyl or a carbonyl and another methylene being optionally substituted by an alkylamine; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C^-β alkylene; or R^ and Rl 6 are linked together to form with N an unsaturated 5- or 6-membered heteroaryl optionally substituted by a C\.4 alkyl;
R!7 is hydrogen or a Cj.g alkyl;
R! 8 is Cj.g alkyl, C\ _g alkyl cycloalkyl or a C\.β alkyl aryl; or R!7 and Rl8 are linked together to form a C3.5 alkylene, each methylene of the alkylene being optionally substituted by one or two C \.4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C^-β cycloalkyl; n and m are independently an integer comprised between 2 and 8; w and r are independentely an integer comprised between 0 and 4; t and z are independentely an integer equal to 0 or 1 ; with the proviso that R4 is -O-(CH2)n-NRl2aRl2b, when R5 is hydrogen and that
R5 is -O-(CH2)m-NRl3aRl3b, when R4 is hydrogen, halogen, trifluoromethyl, C1.4 alkyl or Ci_4 alkoxy; with the proviso that when Rl 1 is an ester or a carboxylic acid, R4 is hydrogen, halogen, C \ .4 alkyl or C 1.4 alkoxy. with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0.
Usually in another embodiment, the invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000020_0001
0)
wherein A1 is CH, C(CH3), C-halogen or N;
R1 is hydrogen or fluorine; R2 is
Figure imgf000021_0001
(H') ;
A3 is O or S;
R3 is hydrogen, fluorine, methyl or methoxy;
R4 is hydrogen, bromine, fluorine, chlorine, methyl, methoxy, trifluoromethyl or - O-(CH2)n-NR12aR12b , each CH2 in -O-(CH2)n-NR12aR12b being optionally substituted by one or two methyl;
R5 is hydrogen or -O-(CH2)m-NR13aR13b, each CH2 in -O-(CH2)m-NR13aR13b being optionally substituted by one or two methyl;
R10 is hydrogen, Cj.g alkyl or -(CH2)w-(C=O)t-NR15R16;
R11 is hydrogen, C j_g alkyl, ester, carboxylic acid, halogen, or -(CH2)r-(C=O)z- NR17R18;
R12a and R12b are linked together to form a C3_6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl;
R13a and R13b are linked together to form a C3_g alkylene, each methylene of the alkylene being optionally substituted by one or two C \.4 alkyl, an amino group or C \.β alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl, a C3_6 cycloalkyl or C1-6 alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C3 _g alkylene;
R15 is hydrogen or a Cj.g alkyl; R1^ is aryl, heteroaryl, C\.g alkyl, C3.6 cycloalkyl, C1-6 alkyl cycloalkyl, Cχ.β alkyl aryl or a CH2-heteroaryl; or R1^ and R1^ are linked together to form a C3_g alkylene, each methylene of the alkylene being optionally substituted by one or two Cj .4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by Cj_6 alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C^.g alkyl or C-^-β cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3_g cycloalkyl or a carbonyl and another methylene being optionally substituted by an alkylamine; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C^-β alkylene; or R^ and Rl 6 are linked together to form with N an unsaturated 5- or 6-membered heteroaryl optionally substituted by a C \ .4 alkyl; R!7 is hydrogen or a Cμg alkyl;
R! 8 is Ci_g alkyl, C\.β alkyl cycloalkyl or C1-6 alkyl aryl; or R!7 and Rl 8 are linked together to form a C3.5 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C^.g alkyl or Cβ.g cycloalkyl; n and m are independently an integer comprised between 2 and 8; w and r are independentely an integer comprised between 0 and 4; t and z are independentely an integer equal to 0 or 1; with the proviso that R4 is -0-(CE^)n-NR l2aRl2b, when R5 is hydrogen and that R^ is -O-(CH2)m-NRl3aRl3b5 when R4 is hydrogen, bromine, fluorine, chlorine, methyl, methoxy, trifluoromethyl; with the proviso that when Rl 1 is an ester or a carboxylic acid, R4 is hydrogen, halogen, Cj.4 alkyl or C^ alkoxy; with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0.
Preferably, the invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000023_0001
(I)
wherein
A1 is CH, C(CH3), C-F or N;
RI is hydrogen; R2 is
Figure imgf000023_0002
(IT)
A3 is O or S; R3 is hydrogen, fluorine or methyl;
R^ is hydrogen, chlorine, bromine, fluorine, methyl, methoxy or -O-(CH2)n~ NR12aR12b.
R5 is hydrogen or -O-(CH2)m-NR13aR13b;
R10 is hydrogen, methyl or -(CH2)W-(C=O)1-NR15R16; R11 is hydrogen, methyl, COOCH3, COOH, bromine or -(CH2)r-(C=O)z-
NR17R18;
-NR12aR12b is 1-pyrrolidinyl.
-NRl3aRl3b is selected from the group consisting of 1-piperidinyl, 1-pyrrolidinyl, 2-methylpyrrolidin-l-yl, (2S)-2-methylpyrrolidin-l-yl, (2R)-2-methylpyrrolidin-l-yl, 4- isopropylpiperazin- 1 -yl, 4-methylpiperidin- 1 -yl, 2-methylpiperidin- 1 -yl, 2-(pyrrolidin- 1 - ylmethyl)pyrrolidin- 1 -yl, 4-cyclopentylpiperazin- 1 -yl, 3 -(dimethylamino)pyrrolidin- 1 -yl, 4-(2-pyrrolidin-l-ylethyl)piperazin-l-yl, 1-azepanyl, 2,6-dimethylpiperidin-l-yl, (2S)-2- (pyrrolidin-l-yhnethyl)pyrrolidin-l-yl, 2-isobutylpyrrolidin-l-yl, 2-ethylpyrrolidinyl and (4aR, 8aS)-octahydroisoquinolin-2-(lH)-yl. -NR15R16 is selected from the group consisting of 1-piperidinyl, 2- methylpyrrolidin-1-yl, 1-pyrrolidinyl, 1-azepanyl, 4-methylpiperidin-l-yl, 2- methylpiperidin- 1 -yl, (3,5 -dimethyl)piperidin- 1 -yl, hexyl(methyl)amino, benzyl(methyl)amino, (2-methoxy-l-methylethyl)amino, 2-azaspiro[5.5]undec-2-yl, 7,8- dimethyl- 1 azaspiro[4.4]non- 1 -yl, 2-oxopyrrolidin- 1 -yl, anilino, 2-methyl- 1 H-imidazol- 1 -yl, lH-l,2,4-triazol-l-yl, [l-(hydroxymethyl)-3-methylbutyl] amino, cyclopentylamino, (1,3- dimethylbutyl)amino, (cyclopropylmethyl)(propyl)amino, 2,6-dimethylpiperidin-l-yl, (2- furylmethyl)(methyl)amino, sec-butyl(propyl)amino, 4-benzylpiperidin-l-yl, 4- cyclopentylpiperazin-1-yl, 4-morpholinyl, (4-fluorobenzyl)amino, (4-chlorobenzyl)amino, 2-oxo-piperidin- 1 -yl, (5 S)-2-oxo-(5 -pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl, (4- fluorophenyl)amino, (4aR, 8aS)-octahydroisoquinoline-2(lH)-yl, (2S)-2-(pyrrolidin-l- ylmethyl)pyrrolidin- 1 -yl, (2-methyl-2H-tetrazol-5-yl)amino, (3-methoxyphenyl)amino, (pyridin-3-yl)amino, (2S)-2-(morpholin-4-ylmethyl)pyrrolidin- 1 -yl, (2S)-2-(morpholin-4- ylmethyl)-5-oxopyrrolidin-l-yl, benzylamino and 4,4-difluoropiperidin-l-yl. -NR 1 ^R 18 is i -piperidinyl, 2-oxopyrrolidin- 1 -yl,
(cyclopropylmethyl)(propyl)amino, cyclopentylamino, benzylamino, (4- cyclopentyl)piperazin-l-yl, 4-morpholinyl or 4,4-difluoropiperidin-l-yl. n is equal to 3; m is an integer comprised between 2 and 4; w is an integer equal to 0, 1 or 2; z is an integer equal to 0 or 1; r is an integer equal to 0, 1 or 2; t is an integer equal to 0 or 1 ; with the proviso that R4 is -O-(CH2)n-NRl2aR12b when R5 is hydrogen and that R^ is -O-(CH2)m-NR^aR^'? when R4 is hydrogen, chlorine, bromine, fluorine, methyl, or methoxy; with the proviso that when R^ 1 is COOCH3 or COOH, R4 is hydrogen, chlorine, bromine, fluorine, methyl, or methoxy; and with the proviso that when R10 is -(CH2)w-(C=O)t-NR15R16, R1 * is hydrogen, methyl, COOCH3, COOH or bromine; and with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0. More preferably, the invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000025_0001
wherein
A1 Is CH9 C-F OrN; R1 is hydrogen; R2 is
Figure imgf000025_0002
(IT)
A3 is O or S;
R3 is hydrogen, fluorine or methyl;
R4 is hydrogen, chlorine, bromine, fluorine or methoxy;
R5 is -O-(CH2)m-NR13aR13b;
R10 is hydrogen, methyl or -(CH2)w-(C=O)t-NR15R16;
R11 is hydrogen, methyl, COOCH3, bromine or -(CH2V(C=O)2-NR17R18.
-NR13aR13b is selected from the group consisting of 1-piperidinyl, 1-pyrrolidinyl, 2-methylpyrrolidin-l-yl, (2S)-2-methylpyrrolidin-l-yl, (2R)-2-methylpyrrolidin-l-yl, 4- isopropylpiperazin-1-yl, 4-methylpiperidin-l-yl, 2-methylpiperidin-l-yl, 2-(pyrrolidin-l- ylmethyl)pyrrolidin- 1 -yl, 4-cyclopentylpiperazin- 1 -yl, 3 -(dimethylamino)pyrrolidin- 1 -yl, 4-(2-pyrrolidin-l-ylethyl)piperazin-l-yl, 1-azepanyl, 2,6-dimethylpiperidin-l-yl, (2S)-2- (pyrrolidin-l-yhnethyl)pyrrolidm-l-yl, 2-isobutylpyrrolidin-l-yl, 2-ethylpyrrolidinyl and (4aR, 8aS)-octahydroisoquinolin-2(lH)-yl. -NR15R16 is selected from the group consisting of 1-piperidinyl, 2- methylpyrrolidin-1-yl, 1-pyrrolidinyl, 1-azepanyl, 2-methylpiperidin-l-yl, (3,5- dimethyl)piperidin-l-yl, hexyl(methyl)amino, benzyl(methyl)amino, 2-azaspiro[5.5]undec- 2-yl, 7,8-dimethyl-lazaspiro[4.4]non-l-yl, 2-oxopyrrolidin-l-yl, anilino, 2-methyl-lH- imidazol-1-yl, lH-l,2,4-triazol-l-yl, [l-(hydroxymethyl)-3-methylbutyl]amino, cyclopentylamino, (l,3-dimethylbutyl)amino, (cyclopropylmethyl)(propyl)amino, 2,6- dimethylpiperidin-1-yl, (2-furylmethyl)(methyl)amino, sec-butyl(propyl)amin, 4- benzylpiperidine-1-yl, 4-cyclopentylpiperazin-l-yl, 4-morpholinyl, (4-fluorobenzyl)amino, (4-chlorobenzyl)amino, 2-oxo-piperidin-l-yl, (5S)-2-oxo-5-pyrrolidin-l-yl, (4- fluorophenyl)amino, (4aR, 8aS)-octahydroisoquinolin-2(lH)-yl, (2S)-2-(pyrrolidin-l- ylmethyl)pyrrolidin-l-yl, (3-methoxyphenyl)amino, (pyridin-3-yl)amino, benzylamino and 4,4-difluoropiperidin- 1 -yl;
-NR17R18 [S l-piperidinyl, 2-oxopyrrolidin-l-yl, (cyclopropylmethyl)(propyl)amino, cyclopentylamino, benzylamino, (4- cyclopentyl)piperazinyl, 4-morpholinyl or 4,4-difluoropiperidin- 1-yl; m is an integer comprised between 2 and 4; w is an integer equal to 0, 1 or 2; z is an integer equal to 0 or 1 ; r is an integer equal to 0, 1 or 2; t is an integer equal to 0 or 1 ; and with the proviso that when R10 is -(CH2)w-(C=O)t-NR15R16, R11 is hydrogen, methyl, COOCH3 or bromine; with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0.
Most preferably, the invention relates to compounds of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000027_0001
(I)
wherein
A1 is CH or C-F;
R1 is hydrogen; R2 is
Figure imgf000027_0002
(H1)
A3 is O or S; R3 is hydrogen or methyl;
R4 is hydrogen or fluorine; R5 is -O-(CH2)m-NR13aR13b;
R10 is methyl or -(CH2)W-(C=O)1-NR15R16;
R11 is hydrogen, bromine, COOCH3 or -(CH2V(C=O)2-NR17R18; -NR13aR131> is selected from the group consisting of 1-piperidinyl, 2- methylpyrrolidin-1-yl, (2S)-2-methylpyrrolidin-l-yl, (2R)-2-methylpyrrolidin-l-yl, 4- methylpiperidin- 1 -yl, 2-methylpiperidin- 1 -yl, 2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl, (2S)-2-(pyrrolidin- 1 -yhnethyl)pyrrolidin- 1 -yl, 2-isobutylpyrrolidin- 1 -yl, 2-ethylpyrrolidin- 1-yl, (4aR, 8aS)-octahydroisoquinolin-2(lH)-yl, l-azepanyl and 2,6-dimethylpiperidin-l- yl;
-NR1SR1^ is 1-piperidinyl, 1-pyrrolidinyl, 2-methylpyrrolidin-l-yl, 7,8-dimethyl- 1 azaspiro [4.4]non- 1 -yl, IH-1 ,2,4-triazol- 1 -yl, [ 1 -(hydroxymethyl)-3 -methylbutyl] amino, 2,6-dimethylpiperidin-l-yl, benzylamino, sec-butyl(propyl)amino, (4aR, 8aS)- octahydroisoquinolin-2( 1 H)-yl and (2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl. -NR 1 ^R 18 is selected from the group consisting of 1-piperidinyl, 2-oxopyrrolidin- 1-yl, (cyclopropylmethyl)(propyl)amino, cyclopentylamino, benzylamino, (4- cyclopentyl)piperazin-l-yl, 4-moφholinyl and 4,4-difluoropiperidin-l-yl. m is an integer equal to 3 and 4; w is an integer equal to 0, 1 or 2; z is an integer equal to 0 or 1; r is an integer equal to 0, 1 or 2; t is an integer equal to 0 or 1; and with the proviso that when R1 ° is -(CH2)w-(C=O)t-NR15R16, R11 is hydrogen,
COOCH3 or bromine; with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0.
In a particular embodiment, the present invention relates to compounds of formula
(Di) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000028_0001
(Ih) wherein L and w are as defined hereabove in the specification; and RlOa is an amino group.
Preferably, R^a is NR^R165 R15 an(j R16 being as defined here above in the specification.
Preferably, w is equal to 1.
Preferably, L is -(CH^)1n-NR13aR13b, m, R13a and R13b being as defined here above in the specification.
Preferably, m is equal to 3. In another particular embodiment, the present invention relates to compounds of formula (Ii) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000029_0001
(Ii) wherein L is as defined hereabove in the specification; w is an integer comprised between 1 and 4; and RlOa is an amino group.
Preferably, R1^ is NR15Rl 6^ R15 an([ R16 being as defined here above in the specification. Preferably w is equal to 1.
Preferably, L is -(CH2VNR13aR13b5 m> R13a and R13b being as defined here above in the specification.
Preferably m is equal to 3.
In another particular embodiment, the present invention relates to compounds of formula (Ij) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000029_0002
(Ij)
wherein L is as defined hereabove in the specification; and
RlOb is an amino group.
Preferably, R10b is NR15R16, R15 and R16 being as defined here above in the specification. Preferably, L is -(CH2)m-NR13aR13b, m, R13a and R13b being as defined here above in the specification.
Preferably m is equal to 3.
In another particular embodiment, the present invention relates to compounds of formula (Ik) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000030_0001
(Ik) wherein L is as defined hereabove in the specification and RlOb is an amino group.
Preferably, R10b is NR15R16, R15 and R16 being as defined here above in the specification.
Preferably, L is -(CH2)m-NR13aR13b, m, R13a and R13b being as defined here above in the specification. Preferably m is equal to 3.
hi another particular embodiment, the present invention relates to compounds of formula (II) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000030_0002
(H) wherein L is as defined hereabove in the specification; r is an integer comprised between 1 and 4; R10c is a C1-6 alkyl;
RI la is an amino group.
Preferably, R1 l a is NR17R18, R17 and R18 being as defined here above in the specification.
Preferably, r is equal to 1 or 2.
Preferably, L is -(CH2)m-NR13aR13b, m, R13a and R13b being as defined here above in the specification.
Preferably m is equal to 3.
In another particular embodiment, the present invention relates to compounds of formula (Im), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000031_0001
W wherein L is as defined hereabove in the specification; r is an integer comprised between 1 and 4; R10c is a C1-6 alkyl;
R1 la is an amino group. Preferably, R1 la is NR17R18, R17 and R18 being as defined here above in the specification.
Preferably, r is equal to 1 or 2.
Preferably, L is -(CH2)m-NR13aR13b, m, R13a and R13b being as defined here above in the specification. Preferably m is equal to 3. In another particular embodiment, the present invention relates to compounds of formula (In) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000032_0001
(In) wherein L is as defined hereabove in the specification;
RlOc is a Ci^ alkyl; R1 lb is an amino group.
Preferably, R1 lb is NR17R18, R17 and R18 being as defined here above in the specification.
Preferably, r is equal to 1 or 2.
Preferably, L is -(CH2)m-NR13aR13b, m, R13a and R13b being as defined here above in the specification.
Preferably m is equal to 3.
hi another particular embodiment, the present invention relates to compounds of formula (Io), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000032_0002
(Io) wherein L is as defined hereabove in the specification; RiOc is a Ci.g alkyl;
R1 lb is an amino group. Preferably, R1 lb is NR17R18, R17 and R18 being as defined here above in the specification.
Preferably, r is equal to 1 or 2.
Preferably, L is -(CH2)m-NR13aR13b, m, R13a and R13b being as defined here above in the specification.
Preferably m is equal to 3
Preferred compounds of formula (I) according to the invention are: l-(3-{4-[4-(piperidin-l-ylmethyl)-l,3-oxazol-2-yl]phenoxy}propyl)piperidine; 1 -[3-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)propyl]piperidine; l-(3- {4-[4-(pyrrolidin-l -ylmethyl)-l ,3-oxazol-2-yl]phenoxy}propyl)piperidine;
1 -( {2- [4-(3 -piperidin- 1 -ylpropoxy)phenyl] -1,3 -oxazol-4-yl} methyl)azepane;
4-methyl-l-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3-oxazol-4- yl}methyl)piperidine;
2-methyl- 1 -( {2-[4-(3 -piperidin- 1 -ylpropoxy)phenyl] - 1 ,3 -oxazol-4- yl} methyl)piperidine;
3 , 5-dimethyl- 1 -( {2- [4-(3 -piperidin- 1 -ylpropoxy)phenyl] - 1 ,3 -oxazol-4- yl}methyl)piperidine; N-hexyl-N-methyl-N-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3-oxazol-4- yl}methyl)amine;
N-benzyl-N-methyl-N-( {2-[4-(3-piperidin- 1 -ylpropoxy)phenyl]-l ,3-oxazol-4- yl } methyi)amine;
4-(pyrrolidin-l-ylmethyl)-2-[4-(3-pyrrolidin-l-ylpropoxy)phenyl]-l,3-oxazole; N-[(2-{4-[3-(4-isopropylpiperazin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)methyl]-
N-methylhexan- 1 -amine;
N-(2-methoxy-l-methylethyl)-N-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3- oxazol-4-yl} methyl)amine;
2-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)methyl]-2- azaspiro[5.5]undecane;
7, 8-dimethyl- 1 -( {2- [4-(3 -piperidin- 1 -ylpropoxy)phenyl] - 1 ,3 -oxazol-4-yl} methyl)- 1 - azaspiro[4.4]nonane;
4-[(2-methylpyrrolidin- 1 -yl)methyl] -2- {4- [3 -(2-methylpyrrolidin- 1 - yl)propoxy]phenyl} - 1 ,3-oxazole; 1 -isopropyl-4-(3- {4- [4-(pyrrolidin- 1 -ylmethyl)- 1 ,3 -oxazol-2- yl]phenoxy}propyl)piperazine; l-isopropyl-4-[3-(4-{4-[(2-methylpiperidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)propyl]piperazine; 4-methyl-l-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl } phenoxy)propyl]piperidine;
2-methyl- 1 -[3-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)propyl]piperidine;
4-[(2-methylpyrrolidin- 1 -yl)methyl]-2-(4- {3-[2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 - yl]propoxy} phenyl)- 1 ,3-oxazole;
1 -cyclopentyl-4- [3 -(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl] - 1 ,3 -oxazol-2- yl}phenoxy)propyl]piperazine;
N,N-dimethyl-l -[4-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)butyl]pyrrolidin-3-amine; 1 -[2-(4- {4-[(2-methylpyrrolidin-l -yl)methyl]- 1 ,3-oxazol-2-yl}phenoxy)ethyl]-4-(2- pyrrolidin- 1 -ylethyl)piperazine;
2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } -4-(2-oxo-2-pyrrolidin- 1 - ylethyl)- 1 ,3-oxazole; l-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]pyrrolidin-2-one;
N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3-oxazol-4-yl)methyl]-N- phenylamine;
2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -4-(2-pyrrolidin- l-ylethyl)-l ,3- oxazole; 4-[(2-methyl-lH-imidazol-l-yl)methyl]-2-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl } - 1 , 3 -oxazole; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)methyl]-lH- 1,2,4-triazole;
4-(pyrrolidin-l-ylmethyl)-2-[3-(3-pyrrolidin-l-ylpropoxy)phenyl]-l,3-oxazole; 1 - [(2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)methyl]piperidine; l-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)propyl]azepane; 1 -(3 - {4- [4-methyl-5-(piperidin- 1 -ylmethyl)- 1 ,3 -oxazol-2- yl]phenoxy}propyl)piperidine;
(2R)-4-methyl-2- { [(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol- 4-yl)methyl]amino}pentan- 1 -ol; N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]cyclopentanamine; l-[4-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl } phenoxy)butyl] azepane;
1 -[2-(4- {4- [(2-methylpyrrolidin- 1 -yl)methyl] - 1 ,3 -oxazol-2- yl}phenoxy)ethyl]azepane;
N-( 1 ,3-dimethylbutyl)-N-[(2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 - oxazol-4-yl)methyl] amine;
N-(cyclopropylmethyl)-N- [(2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1,3- oxazol-4-yl)methyl]-N-propylamine; l-[3-(4-{4-[(2,6-dimethylpiperidin-l-yl)methyl]-l,3-oxazol-2-yl}phenoxy)propyl]-
2,6-dimethylpiperidine;
1 -( {2-[4-(2-piperidin- 1 -ylethoxy)phenyl]- 1 ,3-oxazol-4-yl} methyl)piperidine; l-[(2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; 2-methyl-l-[4-(4-{4-[(2-methylρyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)butyl]piperidine;
1 -(3 - {4- [4-(piperidin- 1 -ylmethyl)- 1 ,3 -thiazol-2-yl]phenoxy } propyl)piperidine;
4-(pyrrolidin-l-ymiethyl)-2-[4-(3-pyrrolidin-l-ylpropoxy)phenyl]-l,3-thiazole;
7,8-dimethyl-l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazol-4- yl)methyl]-l-azaspiro[4.4]nonane;
N-(2-rurylmethyl)-N-methyl-N-[(2-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl} - 1 , 3 -thiazol-4-yl)methyl] amine;
N-(sec-butyl)-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazol-4- yl)methyl] -N-propylamine; l-(3-{4-[4-(pyrrolidin-l-ylmethyl)-l,3-thiazol-2-yl]phenoxy}propyl)piperidine; l-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3-thiazol-4-yl}methyl)azepane; l-[(2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy]phenyl} - 1 ,3-tbiazol-4- yl)methyl]piperidine; 1 -[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)acetyl]piperidine; l-(3-{4-[4-(2-oxo-2-piperidin-l-ylethyl)-l,3-oxazol-2-yl]phenoxy}propyl)piperidine;
1 -[2-(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)ethyl]piperidine;
2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-thiazole;
4-benzyl- 1 -[(2- {4-[3-(2-methylpyrrolidin- l-yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine;
1 -cyclopentyl-4-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperazine;
1 - { [2-(4- {3-[(2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl]propoxy}phenyl)- 1 ,3 - oxazol-4-yl]methyl}piperidine; l-(3-{4-[5-methyl-4-(piperidin-l-ylmethyl)-l,3-oxazol-2- yl]phenoxy } propyl)piperidine; 1 -(3- {2-fluoro-4-[4-(piperidin- l-ylmethyl)-l ,3-oxazol-2-yl]phenoxy}propyl)piperidine; l-(3-{2,6-dimethyl-4-[4-(piperidin-l-ylmethyl)-l,3-oxazol-2- yl]phenoxy}propyl)piperidine;
4-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)carbonyl]moφholine; 1 -cyclopentyl-4-( {2-[4-(3-piperidin- 1 -ylpropoxy)phenyl] - 1 ,3-oxazol-4- yl} carbonyl)piperazine; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)carbonyl]piperidine;
1 -cyclopentyl-4-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)carbonyl]piperazine;
4-[(2-methylpyrrolidin- 1 -yl)methyl] -2-(4- {3-[(2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin-
1 -yl]propoxy} phenyl)- 1 ,3-oxazole; l-[(2-{3-fluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; 1 -[(4-methyl-2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy]phenyl} -1 ,3-oxazol-5- yl)carbonyl]piperidine;
N-(cyclopropylmethyl)-4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-
N-propyl- 1 ,3 -oxazole-5-carboxamide; N-cyclopentyl-4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1,3- oxazole-5-carboxamide; methyl 4-[(benzylamino)methyl]-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -
1 ,3-oxazole-5-carboxylate; methyl 4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazole-5- carboxylate;
2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } -4-(piperidin- 1 -ylmethyl)- 1,3- oxazole-5-carboxylic acid;
N-(cyclopropylmethyl)-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-N-propyl- l,3-oxazole-4-carboxamide;
N-cyclopentyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazole-4- carboxamide;
N-(4-fluorobenzyl)-2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3-oxazole-4- carboxamide; N-benzyl-4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazole-5- carboxamide;
1 -cyclopentyl-4- [(4-methyl-2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 - oxazol-5-yl)carbonyl]piperazine;
2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-4-(pyrrolidin-l-ylcarbonyl)-l,3- oxazole;
4-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-5- yl)carbonyl]morpholine;
4-{[4-methyl-2-(4-{3-[(2R)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3-oxazol-5- yl]carbonyl}morpholine; 4-{[4-methyl-2-(4-{3-[(2S)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3-oxazol-5- yl]carbonyl}morpholine;
1 -cyclopentyl-4- [(4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3- oxazol-5-yl)methyl]piperazine;
N-(cyclopropymiethyl)-N-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl}-l,3-oxazol-5-yl)methyl]-N-propylamine;
N-benzyl-N-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-
5 -yl)methyl] amine; l-[(2- {3-methoxy-4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine; N-(4-chlorobenzyl)-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-
4-yl)methyl] amine;
N-[(4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3-oxazol-5- yl)methyl] cyclopentanamine; 1 -[(5-bromo-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine;
1 - { [2-(4- {3-[(2R)-2-methylpyrrolidin- 1 -yl]propoxy}phenyl)- 1 ,3-oxazol-4- yl]methyl}piperidine; l-{[2-(4-{3-[(2S)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3-oxazol-4- yl]methyl}piperidine;
4-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]morpholine; l-[2-(2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3-oxazol-4- yl)ethyl]piρeridine; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidin-2-one;
(5S)- 1 -[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4-yl)methyl]-5-
(pyrrolidin- 1 -ylmethyl)pyrrolidin-2-one;
1 -[(2- {3 -chloro-4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine; l-[(2- {4-[3-(2-isobutylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine; methyl 2- {3-bromo-4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -4-methyl- 1,3- thiazole-5-carboxylate; l-(3-{4-[4-methyl-5-(2-oxo-2-piperidin-l-ylethyl)-l,3-thiazol-2- yl]phenoxy}propyl)piperidine;
N-(4-fluorophenyl)-2-(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-
4-yl)acetamide;
1 -[(2- {4-[3-(2-ethylpyrrolidin- 1 -yl)propoxy]phenyl}-l ,3-oxazol-4- yl)methyl]piperidine;
(4aR,8aS)-2-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]ρhenyl}-l,3-oxazol-4- yl)methyl]decahydroisoquinoline;
2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -4- {[(2S)-2-(pyrrolidin- 1 - ylmethyl)pyrrolidin- 1 -yl]carbonyl} - 1 ,3-oxazole; 4-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)acetyl]morpholine;
N-cyclopentyl-2-(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)acetamide; N-(cyclopropylmethyl)-2-(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]plienyl}-l,3- oxazol-4-yl)-N-propylacetamide; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)acetyl]azepane; l-(3-{4-[4-methyl-5-(2-piperidin-l-ylethyl)-l,3-thiazol-2- yljphenoxy } propyl)piperidine; (5S)- 1 -[(2- {4-[3-(2-methylρyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3-oxazol-4-yl)methyl]-5-
(morpholin-4-ylmethyl)pyrrolidin-2-one;
(4aS,8aR)-2-(3-{4-[4-(piperidin-l-ylmethyl)-l,3-oxazol-2- yl]phenoxy}propyl)decahydroisoquinoline;
2-methyl-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl] -2H-tetraazol-5 -amine;
N-(3-methoxyphenyl)-N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1,3- oxazol-4-yl)methyl] amine;
N-(4-fluorophenyl)-N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-
4-yl)methyl] amine; N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)methyl]pyridin-
3-amine;
4-[(4-methyl-2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy]phenyl} - 1 ,3-oxazol-5- yl)methyl]morpholine;
4-({(2S)-l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]pyrrolidin-2-yl } methyl)morpholine; l-[(2-{2-fluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine;
4,4-difluoro- 1-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - l,3-oxazol-4- yl)methyl]piperidine; 4-[(4-methyl-2- {6- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]pyridin-3 -yl}-l ,3 -thiazol-5 - yl)carbonyl]morpholine; l-[(2-{3,5-difluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; 4,4-difluoro- 1 -[(4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1,3- thiazol-5-yl)carbonyl]piperidine;
4,4-difluoro-l-{[4-methyl-2-(4-{3-[(2R)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3- thiazol-5-yl]carbonyl}piperidine; 4,4-difluoro-l-{[4-methyl-2-(4-{3-[(2S)-2-methylpyrrolidin-l-yl]ρropoxy}ρhenyl)-l,3- thiazol-5-yl]carbonyl}piperidine;
4-[(4-methyl-2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy]phenyl} - 1 ,3-thiazol-5- yl)carbonyl]moφholine;
4-{[4-methyl-2-(4-{3-[(2R)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3-thiazol-5- yl]carbonyl}morpholine;
4-{[4-methyl-2-(4-{3-[(2S)-2-niethylpyrrolidin-l-yl]propoxy}phenyl)-l,3-thiazol-5- yljcarbonyl} morpholine; l-[(2-{2-methyl-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; and l-[(4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-thiazol-5- yl)methyl]pyrrolidin-2-one.
More preferred compounds of formula (I) according to the invention are
1 -(3- {4- [4-(piperidin- 1 -ylmethyl)- 1 ,3 -oxazol-2-yl]phenoxy} propyl)piperidine; l-[3-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- l,3-oxazol-2- yl}phenoxy)propyl]piperidine;
1 -(3 - {4- [4-(pyrrolidin- 1 -ylmethyl)- 1 ,3 -oxazol-2-yl]phenoxy} propyl)piperidine; l-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3-oxazol-4-yl}methyl)azepane;
2-methyl-l-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3-oxazol-4- yl } methyl)piperidine;
3,5-dimethyl-l-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3-oxazol-4- yl } methyl)piperidine;
N-hexyl-N-methyl-N-( {2-[4-(3 -piperidin- 1 -ylpropoxy)phenyl]- 1 ,3 -oxazol-4- yl}methyl)amine; N-benzyl-N-methyl-N-( {2-[4-(3-piperidin- 1 -ylpropoxy)phenyl]- 1 ,3-oxazol-4- yl}methyl)amine;
4-(pyrrolidin-l-ylmethyl)-2-[4-(3-pyrrolidin-l-ylpropoxy)phenyl]-l,3-oxazole;
2-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)methyl]-2- azaspiro[5.5]undecane; 7, 8-dimethyl- 1-({2-[4-(3 -piperidin- 1 -ylpropoxy)phenyl] -1,3 -oxazol-4-yl} methyl)- 1 - azaspiro[4.4]nonane;
4-[(2-methylpyrrolidin-l-yl)methyl]-2-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl } - 1 , 3 -oxazole; 1 -isopropyl-4-(3- {4-[4-(pyrrolidin- 1 -ylmethyl)- 1 ,3-oxazol-2- yl]phenoxy} propyl)piperazine; l-isopropyl-4-[3-(4-{4-[(2-methylpiperidin-l-yl)methyl]-l,3-oxazol-2- yl } phenoxy)propyl]piperazine;
4-methyl-l-[3-(4-{4-[(2-methylρyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)propyl]piperidine;
2-methyl-l -[3-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl } phenoxy)propyl]piperidine;
4- [(2-methylpyrrolidin- 1 -yl)methyl] -2-(4- {3 - [2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 - yl]propoxy}phenyl)- 1 ,3-oxazole; l-cyclopentyl-4-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)propyl]piperazine;
N,N-dimethyl- 1 -[4~(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl] -1,3 -oxazol-2- yl } phenoxy)butyl]pyrrolidin-3 -amine; l-[2-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2-yl}phenoxy)ethyl]-4-(2- pyrrolidin-l-ylethyl)piperazine;
2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -4-(2-oxo-2-pyrrolidin- 1 - ylethyl)- 1 ,3-oxazole; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]pyrrolidin-2-one; N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)methyl]-N- phenylamine;
2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } -4-(2-pyrrolidin- 1 -ylethyl)- 1,3- oxazole;
4-[(2-methyl- 1 H-imidazol- 1 -yl)methyl]-2- {4- [3 -(2-methylpyrrolidin- 1 - yl)propoxy]phenyl} -1,3 -oxazole;
1 - [(2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1,3 -oxazol-4-yl)methyl]- 1 H- 1,2,4-triazole; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; l-[3-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]-l,3-oxazol-2- yl}phenoxy)propyl]azepane;
1 -(3- {4-[4-methyl-5-(piperidin- 1 -ylmethyl)- 1 ,3 -oxazol-2- yl]phenoxy}propyl)piperidine; (2R)-4-methyl-2-{[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-
4-yl)methyl] amino }pentan- 1 -ol;
N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)methyl] cyclopentanamine;
1 -[4-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)butyl]azepane;
1 -[2-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)ethyl]azepane;
N-(l,3-dimethylbutyl)-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3- oxazol-4-yl)methyl]amine; N-(cyclopropylmethyl)-N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3- oxazol-4-yl)methyl]-N-propylamine;
1 -[3 -(4- {4-[(2,6-dimethylpiperidin- 1 -yl)methyl] -1,3 -oxazol-2-yl} phenoxy)propyl] - 2,6-dimethylpiperidine; l-[(2- {4-[2-(2-methylpyrrolidin- 1 -yl)ethoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine;
2-methyl- 1 -[4-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)butyl]piperidine; l-(3- {4-[4-(piperidin- 1 -ylmethyl)- 1 ,3-thiazol-2-yl]phenoxy}propyl)piperidine;
4-(pyrrolidin- 1 -ylmethyl)-2-[4-(3-pyrrolidin- 1 -ylpropoxy)phenyl]- 1 ,3-thiazole; 7, 8-dimethyl- 1 -[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -thiazol-4- yl)methyl]-l-azaspiro[4.4]nonane;
N-(2-furylmethyl)-N-methyl-N-[(2-{4-[3-(2-methylρyrrolidin-l- yl)propoxy]phenyl}-l,3-thiazol-4-yl)methyl]arnme;
N-(sec-butyl)-N-[(2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1,3 -thiazol-4- yl)methyl]-N-propylamine; l-(3-{4-[4-(pyrrolidin-l-ylmethyl)-l,3-thiazol-2-yl]phenoxy}propyl)piperidine;
1 -( {2-[4-(3 -piperidin- 1 -ylpropoxy)phenyl] -1,3 -thiazol-4-yl} methyl)azepane;
1 -[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-thiazol-4- yl)methyl]piperidine; 1 -[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)acetyl]piperidine;
1 - [2-(2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)ethyl]piperidine; 2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazole;
4-benzyl-l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine;
1 -cyclopentyl-4- [(2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)methyl]piperazine; l-{[2-(4-{3-[(2S)-2-(ρyrrolidin-l-ylmethyl)pyrrolidin-l-yl]propoxy}phenyl)-l,3- oxazol-4-yl]methyl}piperidine;
1 -(3- {4-[5-methyl-4-(piperidin- 1 -ylmethyl)- 1 ,3-oxazol-2- yl]phenoxy}propyl)piperidine;
1 -(3- {2-fluoro-4-[4-(piperidin- 1 -ylmethyl)- 1 ,3 -oxazol-2- yljphenoxy} propyl)piperidine;
4- [(2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 , 3 -oxazol-4- yl)carbonyl]moφholine;
1 - [(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 , 3 -oxazol-4- yl)carbonyl]piperidine; 1 -cyclopentyl-4- [(2- {4- [3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)carbonyl]piperazine;
4-[(2-methylpyrrolidin- 1 -yl)methyl]-2-(4- {3-[(2S)-2-(pyrrolidin-l - ylmethyl)pyrrolidin- 1 -yljpropoxy} phenyl)- 1 ,3-oxazole; l-[(2-{3-fluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine;
1 - [(4-methyl-2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-5- yl)carbonyl]piperidine;
N-(cyclopropylmethyl)-4-methyl-2- {4-[3 -(2-methylpyrrolidin- 1 - yl)propoxy]phenyl}-N-propyl-l,3-oxazole-5-carboxamide; N-cyclopentyl-4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3- oxazole-5-carboxamide; methyl 4- [(benzylamino)methyl] -2- {4-[3 -(2-methylpyrrolidin- 1 - yl)propoxy]phenyl}-l,3-oxazole-5-carboxylate; methyl 4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazole-5- carboxylate;
N-(cyclopropylmethyl)-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-N- propyl- 1 ,3-oxazole-4-carboxamide; N-cyclopentyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazole-4- carboxamide;
N-(4-fluorobenzyl)-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazole- 4-carboxamide;
N-benzyl-4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]plienyl}-l,3-oxazole- 5-carboxamide; l-cyclopentyl-4-[(4-methyl-2-{4-[3-(2-methylpyiτolidin-l-yl)propoxy]phenyl}-l,3- oxazol-5-yl)carbonyl]piperazine;
2- {4- [3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } -4-(pyrrolidin- 1 -ylcarbonyl)- 1,3- oxazole; 4-[(4-methyl-2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy]phenyl} - 1 ,3-oxazol-5- yl)carbonyl]morpholine;
4-{[4-methyl-2-(4-{3-[(2R)-2-methylpj'τrolidin-l-yl]propoxy}phenyl)-l,3-oxazol- 5-yl]carbonyl} morpholine;
4-{[4-methyl-2-(4-{3-[(2S)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3-oxazol-5- yl]carbonyl}moφholine;
1 -cyclopentyl-4- [(4-methyl-2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 - oxazol-5-yl)methyl]piperazine;
N-(cyclopropylmethyl)-N-[(4-methyl-2- {4-[3 -(2-methylpyrrolidin- 1 - yl)propoxy]phenyl}-l,3-oxazol-5-yl)methyl]-N-propylamine; N-benzyl-N-[(4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1,3- oxazol-5-yl)methyl]amine;
1 -[(2- {3 -methoxy-4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine;
N-(4-chlorobenzyl)-N-[(2- {4-[3-(2-methylpyrrolidin- l-yl)propoxy]phenyl} -1 ,3- oxazol-4-yl)methyl] amine;
N-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-5- yl)methyl]cyclopentanamine; l-[(5-bromo-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; l-{[2-(4-{3-[(2R)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3-oxazol-4- yl]methyl}piperidine;
1- {[2-(4- {3-[(2S)-2-methylpyrrolidin- 1 -yl]propoxy} phenyl)- 1 ,3-oxazol-4- yl]methyl}piperidine; 4-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]moφholine;
1 -[2-(2- {4-[2-(2-methylpyrrolidin- 1 -yl)ethoxy]phenyl} - 1 ,3-oxazol-4- yl)ethyl]piperidine;
1 -[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidin-2-one;
(5 S)- 1 - [(2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)methyl]-5-(pyrrolidin- 1 -ylmethyl)pyrrolidin-2-one;
1 -[(2- {3 -chloro-4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine; 1 -[(2- {4-[3-(2-isobutylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)methyl]piperidine; methyl 2- {3 bromo-4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -4-methyl- 1 ,3- thiazole-5 -carboxylate;
N-(4-fluorophenyl)-2-(2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy]phenyl} - 1 ,3- oxazol-4-yl)acetamide; l-[(2- {4-[3-(2-ethylpyrrolidin-l -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine;
(4aR,8aS)-2-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl] decahydroisoquinoline; 2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -4- { [(2S)-2-(pyrrolidin- 1 - ylmethyl)pyrrolidin- 1 -yl]carbonyl} - 1 ,3-oxazole;
4-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)acetyl]morpholine;
N-cyclopentyl-2-(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3-oxazol-4- yl)acetamide;
N-(cyclopropylmethyl)-2-(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3- oxazol-4-yl)-N-propylacetamide; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)acetyl]azepane; 1 -(3- {4-[4-methyl-5-(2-piperidin-l -ylethyl)- 1 ,3-thiazol-2- yl]phenoxy}propyl)piperidine;
(4aS,8aR)-2-(3-{4-[4-(piperidin-l-ylmethyl)-l,3-oxazol-2- yl]phenoxy}propyl)decahydroisoquinoline; N-(3 -methoxyphenyl)-N- [(2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1,3- oxazol-4-yl)methyl] amine;
N-(4-fluorophenyl)-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3- oxazol-4-yl)methyl] amine;
N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)methyl]pyridin-3 -amine; l-[(2-{2-fluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine;
4,4-difluoro-l -[(2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine; 4-[(4-methyl-2-{6-[3-(2-methylpyrrolidin-l-yl)propoxy]pyridin-3-yl}-l,3-thiazol-5- yl)carbonyl]morpholine; l-[(2-{3,5-difluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine;
4,4-difluoro-l-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3- thiazol-5-yl)carbonyl]piperidine;
4,4-difluoro- 1 - { [4-methyl-2-(4- {3-[(2R)-2-methylpyrrolidin- 1 -yl]propoxy}phenyl)- l,3-thiazol-5-yl]carbonyl}piperidine;
4,4-difluoro-l-{[4-methyl-2-(4-{3-[(2S)-2-methylpyrrolidin-l-yl]propoxy}phenyl)- l,3-thiazol-5-yl]carbonyl}piperidine; 4-[(4-methyl-2- {4- [3 -(2-methylpyrrolidin- 1 -yl)proρoxy]ρhenyl} -1 ,3-thiazol-5- yl)carbonyl]morpholine;
4- {[4-methyl-2-(4- {3-[(2R)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l ,3-thiazol- 5-yl]carbonyl}morpholine;
4-{[4-methyl-2-(4-{3-[(2S)-2-methylpyrrolidin-l-yl]propoxy}-phenyl)-l,3-thiazol-5- yl]carbonyl}morpholine; l-[(2- {2-methyl-4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3-oxazol-4- yl)methyl]piperidine; and
1 -[(4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-thiazol-5- yl)methyl]pyrrolidin-2-one. Most preferred compounds of formula (I) according to the invention are l-(3-{4-[4- (piperidin-l-ylmethyl)-l,3-oxazol-2-yl]phenoxy}propyl)piperidine;
1 -[3-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl] - 1 ,3-oxazol-2- yl}phenoxy)propyl]piperidine;
4-[(2-methylpyrrolidin- 1 -yl)methyl]-2- {4-[3-(2-methylpyrrolidin-l - yl)propoxy]phenyl} - 1 ,3-oxazole;
4-methyl-l-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)propyl]piperidine; 2-methyl-l-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)propyl]piperidine;
4-[(2-methylpyrrolidin-l-yl)methyl]-2-(4-{3-[2-(pyrrolidin-l-ylmethyl)pyrrolidin-l- yl]propoxy}phenyl)-l,3-oxazole;
2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -4-(2-pyrrolidin- 1 -ylethyl)- 1,3- oxazole;
1 -[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4-yl)methyl]- 1 H- 1,2,4-triazole; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; l-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)propyl]azepane;
(2R)-4-methyl-2- { [(2- {4-[3-(2-methylρyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol- 4-yl)methyl] amino }pentan- 1 -ol;
1 -[4-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}ρhenoxy)butyl]azepane; l-[3-(4-{4-[(2,6-dimethylpiperidin-l-yl)methyl]-l,3-oxazol-2-yl}phenoxy)propyl]- 2,6-dimethylpiperidine;
2-methyl-l-[4-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)butyl]piperidine; 758-dimethyl-l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]ρhenyl}-l,3-thiazol-4- yl)methyl]- 1 -azaspiro[4.4]nonane;
N-(sec-butyl)-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazol-4- yl)methyl]-N-propylamine; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazol-4- yl)methyl]piperidine; l-{[2-(4-{3-[(2S)-2-(pyrrolidin-l-ylmethyl)pyrrolidin-l-yl]propoxy}pheiiyl)-l,3- oxazol-4-yl]methyl}piperidine; 4-[(2-methylpyrrolidin-l-yl)methyl]-2-(4-{3-[(2S)-2-(pyrrolidin-l- ylmethyl)pyrrolidin-l-yl]propoxy}phenyl)-l,3-oxazole; methyl 4- [(benzylamino)methyl] -2- {4- [3 -(2-methylpyrrolidin- 1 - yl)propoxy]phenyl} - 1 , 3 -oxazole-5 -carboxylate;
4-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-5- yl)carbonyl]morpholine;
4- {[4-methyl-2-(4- {3-[(2R)-2-methylpyrrolidin- 1 -yl]propoxy} phenyl)- 1 ,3-oxazol- 5-yl]carbonyl} morpholine;
4- { [4-methyl-2-(4- {3 - [(2 S)-2-methylpyrrolidin- 1 -yl]propoxy} phenyl)- 1 ,3 -oxazol-5- yl]carbonyl}morpholine; 1 -cyclopentyl-4- [(4-methyl-2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 - oxazol-5-yl)methyl]piperazine;
N-(cyclopropylmethyl)-N-[(4-meth}d-2-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl}-l,3-oxazol-5-yl)methyl]-N-propylamine;
N-benzyl-N-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3- oxazol-5-yl)methyl]amine;
N- [(4-methyl-2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 -oxazol-5 - yl)methyl] cyclopentanamine;
1 - [(5-bromo-2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 -oxazol-4- yl)methyl]piperidine; l-{[2-(4-{3-[(2R)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3-oxazol-4- yl]methyl}piperidine;
1 - [(2- {4- [3 -(2-isobutylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)methyl]piperidine; l-[(2-{4-[3-(2-ethylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine;
(4aR,8aS)-2-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]ρhenyl}-l,3-oxazol-4- yl)methyl] decahydroisoquinoline;
2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -4- { [(2S)-2-(pyrrolidin- 1 - ylmethyl)pyrrolidin- 1 -yl] carbonyl} - 1 ,3 -oxazole; l-(3-{4-[4-methyl-5-(2-piperidin-l-ylethyl)-l,3-thiazol-2- yl]phenoxy}propyl)piperidine;
(4aS,8aR)-2-(3-{4-[4-(piperidin-l-ylmethyl)-l,3-oxazol-2- yl]phenoxy}propyl)decahydroisoquinoline; l-[(2-{3,5-difluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine;
4,4-difluoro- 1 -[(4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1,3- thiazol-5-yl)carbonyl]piperidine;
4,4-difluoro- 1 - {[4-methyl-2-(4-{3-[(2R)-2-methylpyrrolidin- 1 -yl]propoxy}phenyl)- 1 ,3-thiazol-5-yl]carbonyl}piperidine;
4-[(4-methyl-2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy]phenyl} - 1 ,3-thiazol-5- yl)carbonyl]morpholine;
4-{[4-methyl-2-(4-{3-[(2R)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3-thiazol- 5-yl]carbonyl} morpholine; l-[(2-{2-methyl-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; l-[(4-τnethyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazol-5- yl)methyl]pyrrolidin-2-one.
The "phaπnaceutically acceptable salts" according to the invention include therapeutically active, non-toxic acid salt forms which the compounds of formula (I) are able to form.
The acid addition salt form of a compound of formula (I) that occurs in its free form as a base can be obtained by treating the free base with an appropriate acid such as an inorganic acid, for example, a hydrohalic such as hydrochloric or hydrobromic, sulfuric, nitric, phosphoric and the like; or an organic acid, such as, for example, acetic, trifiuoroacetic, hydroxyacetic, propanoic, lactic, pyruvic, malonic, succinic, maleic, fumaric, malic, tartaric, citric, methanesulfonic, ethanesulfonic, benzenesulfonic, p- toluenesulfonic, cyclamic, salicylic, p-aminosalicylic, pamoic, and the like. Conversely said salt forms can be converted into the free forms by treatment with an appropriate base.
Preferred salt forms are maleate, tartrate, fumarate, chlorhydrate, and trifluoroacetate.
Compounds of the formula (I) and their salts can be in the form of a solvate, which is included within the scope of the present invention. Such solvates include for example hydrates, alcoholates and the like.
Many of the compounds of formula (I) and some of their intermediates have at least one stereogenic center in their structure. This stereogenic center may be present in a R or a S configuration, said R and S notation is used in correspondence with the rules described in Pure Appl. Chem., 45 (1976) 11-30.
The invention also relates to all stereoisomeric forms such as enantiomeric and diastereoisomeric forms of the compounds of formula (I) or mixtures thereof (including all possible mixtures of stereoisomers). With respect to the present invention reference to a compound or compounds is intended to encompass that compound in each of its possible isomeric forms and mixtures thereof, unless the particular isomeric form is referred to specifically.
Compounds according to the present invention may exist in different polymorphic forms. Although not explicitly indicated in the above formula, such forms are included within the scope of the present invention.
The invention also includes within its scope prodrug forms of the compounds of formula (I) and its various sub-scopes and sub-groups.
The term "prodrug" as used herein includes compound forms which are rapidly transformed in vivo to the parent compound according to the invention, for example, by hydrolysis in blood. Prodrugs are compounds bearing groups which are removed by biotransformation prior to exhibiting their pharmacological action. Such groups include moieties which are readily cleaved in vivo from the compound bearing it, which compound after cleavage remain or becomes pharmacologically active. Metabolically cleavable groups form a class of groups well known to practitioners of the art. They include, but are not limited to such groups as alkanoyl (i.e. acetyl, propionyl, butyryl, and the like), unsubstituted and substituted carbocyclic aroyl (such as benzoyl, substituted benzoyl and 1- and 2-naphthoyl), alkoxycarbonyl (such as ethoxycarbonyl), trialklysilyl (such as trimethyl- and triethylsilyl), monoesters formed with dicarboxylic acids (such as succinyl), phosphate, sulfate, sulfonate, sulfonyl, sulfϊnyl and the like. The compounds bearing the metabolically cleavable groups have the advantage that they may exhibit improved bioavailability as a result of enhanced solubility and/or rate of absorption conferred upon the parent compound by virtue of the presence of the metabolically cleavable group. T. Higuchi and V. Stella, "Pro-drugs as Novel Delivery System", Vol. 14 of the A.C.S. Symposium Series; "Bioreversible Carriers in Drug Design", ed. Edward B. Roche, American Pharmaceutical Association and Pergamon Press, 1987.
A. According to one embodiment of the present invention, compounds of general formula (I) wherein R2 is (IF), A3 is an oxygen atom or a sulfur atom, hereafter referred to as compounds of formula (Id), may be obtained after several reaction steps starting from compounds (XI) and (XII), via intermediates (XIII), as shown in Scheme 9.
Figure imgf000051_0001
Scheme 9
Alternatively, compounds of general formula (Id) may be obtained from compounds (XI) and (Xllbis), via intermediates (XHIbis), as shown in Scheme 9bis.
Figure imgf000051_0002
Scheme 9bis
Unless specified otherwise in Schemes 9 to 13,
- groups R1, R3, R4, R5 , R12a, R12b, R13a, R13b, R15 and Rl6, A1 and A3, w, r, z and t, and provisos are as defined for compounds of general formula (I);
- R10 is Ci_4 alkyl, preferably methyl, or -(CH2)W-(C=O)4-NR15R16;
- R11 is H, a C1-4 alkyl, preferably a methyl or -(CH2V(C=O)2-NR17R18 - R4' is R4 as defined above in the specification for compounds of formula (I); or is -O- (CH2)n-Cl or hydroxy or O-CH2-phenyl; when R4' is C\ .4 alkoxy, it is preferably a methoxy. R.5' is R.5 as defined above in the specification for compounds of formula (I); or -O- (CH2)m"Cl or hydroxy or C \ .4 alkoxy or O-CHrj-phenyl or a chlorine atom; when R^' is Cj_4 alkoxy, it is preferably a methoxy.
- Q is hydrogen, COOR', CO-NR15R16 or a halogen atom, said halogen atom being preferably a chlorine or a bromine atom;
- Q ' is hydrogen, COOR' , halogen or -(C=O)2-NR17R 18
- R' is hydrogen or a C 1.4 alkyl, preferably a methyl or an ethyl.
- X is a halogen atom, preferably chlorine or bromine atom;
In a particular embodiment, when A^ is a sulfur atom, compounds (XI) may be obtained by reacting compounds of formula (XI), in which A^ is an oxygen atom, with a sulfur-releasing reagent according to any conventional method known to the man skilled in the art.
Preferably, the reaction represented in Scheme 9 and Scheme 9 bis is applied to compounds of formula (XI) wherein A^ is CH.
Compounds (XI), wherein A^ is an oxygen or a sulfur atom and R^' is -O-(CH2)n- Cl or R5' is -O-(CH2)m-Cl, may be obtained from the corresponding hydroxy-amides, i.e. (XI) wherein R4' or R5' is hydroxy, according to the same procedure described in step (iiib) of Scheme 15, or according to conventional methods known to the man skilled in the art. Hydroxy-amides of formula (XI) wherein R4' or R^' is hydroxy are commercially available or obtained according to conventional methods known to the man skilled in the art.
Compounds (XII) and (Xllbis) are commercially available or may be synthetized according to conventional methods known to the man skilled in the art. Preferably, bromination of the corresponding methyl-ketone according to Ebike, H. et al. Tetrahedron: Asymmetry 1992, 3, 1153 will be used.
Compounds (XIII), wherein A^ is an oxygen or a sulfur atom, Q is halogen, preferably chlorine or bromine, w is equal to 1, t is equal to 0; R^' is -O-(CH2)n-Cl or R^' is -O-(CH2)m-Cl, may be obtained from the reaction of compounds (XI) and compounds (XII), wherein Q is as defined for compounds (XIII), according to methods described by Prager et al. in J. Chem.Soc, Perkin Trans. 1, 1997, 17, 2665.
Compounds (XHIbis), wherein A^ is an oxygen or a sulfur atom, Q' is a halogen atom, preferably a chlorine or a bromine atom, w is equal to 1, t is equal to 0; R^' is -O- (CH2)n-Cl or R5' is -O-(CH2)m-Cl, may be obtained from the reaction of compounds (XI) and compounds (Xllbis), wherein Q' is as defined for compounds (XHIbis), according to methods described by Prager et al. in J. Chem.Soc, Perkin Trans. I, 1997, 17, 2665.
Alternatively, compounds (XIII) and (XHIbis) wherein Q or Q' is a halogen, wherein A3 is an oxygen or a sulfur atom, may be obtained from compounds (XIII) and (XHIbis), wherein Q or Q' = H by the reaction with N-bromosuccinimide or N- chlorosuccinimide in a solvent such as carbon tetrachloride, or according to conventional methods known to the man skilled in the art.
Alternatively, compounds (Id), may be obtained via intermediates (XIII) or (XHIbis), according to methods represented in Scheme 10 and Scheme lObis.
Figure imgf000053_0001
Usually, reactions according to Schemes 10 and lObis are applied to compounds of formula (XIII), (Xlllbis) and (Id), wherein
- Ra and R^ are H, C^ .4 alkyl, or Ra and R^ are linked together to form a C2-.3 alkylene; and
- Al is CH or C(CH3); Rl is hydrogen or halogen, preferably a fluorine atom; R3 is hydrogen, halogen, C 1.4 alkyl or C \ .4 alkoxy; R4' is hydrogen, halogen, C\ .4 alkyl, C 1.4 alkoxy or trifluoromethyl; R^' is respectively R^ as defined in general formula (I), or R5' is hydroxy, O-CH2-Phenyl or C 1.4 alkoxy, O-(CH2)n-Cl or O- (CH2)n-NRl3aR13b, or chlorine; R4 and R5 are as defined above in the specification for compounds of formula (I); Rl ° is -(CH2)w-(C=O)t-NRl5R16 wherein t is equal to 0 and w is equal to 1 or wherein t is equal to 1 and w is equal to 0 or 1; R1 1 is -(CE^V(C=O)2-NR17R18 wherein z is equal to 0 and w is equal to 1 or wherein z is equal to 1 and r is equal to 0 or 1; or -A! is a nitrogen atom, Rl, R^ and R^'is R^ as defined in general formula (I), or hydrogen; Rβ' is respectively R^ as defined in general formula (I), or R^' is O-
(CH2)n-Cl or O-(CH2)n-NRl3aRl3b5 or an halogen atom, preferably a chlorine atom; RI 1, R^ and R^ are as defined above in the specification for compounds of formula (I); Rl 1, R^ and R^ are as defined above in the specification for compounds of formula (I); R10 is -(CH2)w-(C=O)t-NRl5Rl6 wherein t is equal to 0 and w is equal to 1 or wherein t is equal to 1 and w is equal to 0 or 1.
Hereafter, reference is made to steps (xiia) of Scheme 10 and Scheme lObis. Intermediates (XV), wherein X is a halogen, preferably a chlorine or a bromine, are reacted with intermediates (XIV) to provide compounds of formula (XIII), preferably in the presence of a palladium-based catalyst such as described by Hodgetts and Kershaw in Org. Lett. 2002, 4, 2905, or according to conventional methods known to the man skilled in the art. Alternatively, intermediates (XIV) are reacted with intermediates (XVbis), wherein X is a halogen, preferably a chlorine or a bromine atom, to provide compounds of formula (Xlllbis).
Depending on the nature of the Q group, and R^' or R^' in intermediate (XIII), the reaction conditions to afford compound (Id) may vary. For example, when R^ Or R^' is O- CH2-Phenyl or C)-CH3, intermediates (XIII) may be treated with a deprotecting agent, for example boron tribromide or H2-PdZC system according to conventional methods known to the man skilled in the art to afford the same intermediates (XIII) wherein R^'or R^' is hydroxy. Said intermediates may be converted to compound (Id) according to methods that we have already described for step (iii) of Scheme 15. In a similar manner, the above described reactions could be applied to compound (Xlllbis).
Hereafter, reference is made to steps (xiib) of Scheme 10 and Scheme 10 bis.
Compounds of formula (XIII) in Scheme 10, wherein w= 0 ; Q is halogen (except fluorine) or trifluoromethanesulfonate; R^ 1 is as defined for (Id), but not halogen, may be transformed into compounds (Id) by metal-mediated coupling reactions with RlO-M, wherein the man skilled in the art will appropriately choose RlO-M amongst boron, tin, magnesium or zinc derivatives. These reactions may be carried out in the presence of a transition metal catalyst complex that the man skilled in the art will deem appropriate, and according to conventional methods known to him. RlO in RlO-M is is amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, C3_g cycloalkyl, 3-8-membered heterocycloalkyl, C1-6-alkyl aryl, Q.g-alkyl heteroaryl, C2-6-alkenyl aryl, C2-6-alkenyl heteroaryl, C2-6-alkynyl aryl, C2-6-alkynyl heteroaryl, C1-6-alkyl cycloalkyl, Cj_6-alkyl heterocycloalkyl, C2-6-alkenyl cycloalkyl, C2-6-alkenyl heterocycloalkyl, C2-6-alkynyl cycloalkyl, C2-6 alkynyl, heterocycloalkyl, C1-6-alkyl carboxy, C1-6-alkyl acyl, C3_g- cycloalkyl acyl, aryl acyl, heteroaryl acyl, C3_g-heterocycloalkyl acyl, C1-6-alkyl acyloxy, C1-6-alkyl alkoxy, C1-6-alkyl alkoxycarbonyl, C1-6-alkyl aminocarbonyl, C1-6-alkyl acylamino, acylamino, C3_g-cycloalkyl acylamino.
Similarly, compounds of formula (XHIbis) in Scheme 10 bis, wherein r= 0 ; Q' is halogen or trifluoromethanesulfonate; RlO is as defined for (Id), but not halogen, may be transformed into compounds (Id) by metal-mediated coupling reactions with RH -M, wherein the man skilled in the art will appropriately choose amongst boron, tin, magnesium or zinc derivatives. These reactions maybe carried out in the presence of a transition metal catalyst complex that the man skilled in the art will deem appropriate, and according to conventional methods known to him. Rl 1 in Rl 1-M is is amino, C\.β alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, C3_g cycloalkyl, 3-8-membered heterocycloalkyl, C1-6- alkyl aryl, C1-6-alkyl heteroaryl, C2-6-alkenyl aryl, C2-6-alkenyl heteroaryl, C2-6-alkynyl aryl, C2-6-alkynyl heteroaryl, C1-6-alkyl cycloalkyl, C1-6-alkyl heterocycloalkyl, C2-6- alkenyl cycloalkyl, C2-6-alkenyl heterocycloalkyl, C2-6-alkynyl cycloalkyl, C2-6 alkynyl and heterocycloalkyl, C1-6-alkyl carboxy, C1-6-alkyl acyl, C3_g-cycloalkyl acyl, aryl acyl, heteroaryl acyl, C3_g-heterocycloalkyl acyl, C1-6-alkyl acyloxy, C1-6-alkyl alkoxy, Cj_g- alkyl alkoxycarbonyl, C1-6-alkyl aminocarbonyl, C1-6-alkyl acylamino, acylamino, C3_g- cycloalkyl acylamino.
Compounds of formula (Xlllbis) in Scheme lObis, wherein r = 0; Q' is halogen (except fluorine) or hydrogen, R^ is as defined for (Id), but not halogen, hydrogen or any acidic functional group, may be transformed into compounds (Id) wherein Rl 1 is Cj _g alkyl aminosulfonyl, or C\.β aryl aminosulfonyl by sequential treatment with an alkyllithium reagent at low temperature, sulfur dioxide and an alkyl or arylamino group as described in Mader, M. M. et al. in Bioorg. Med. Chem. Let. 2005, 15, 617-620 or Rooney, C. S. et al in J. Org. Chem. 1984, 49, 2212-2217 or any conventional methods known to the man skilled in the art.
Compounds of general formula (XV) or (XVbis) may be prepared according to methods described by Hodgett and Kershaw in Org. Lett. 2002, 4, 2905, or Young at al. in Tetrahedron Lett. 2004, 45, 3797, or according to conventional methods known to the man skilled in the art.
Compounds (XV) and (XVbis) wherein w = 0 and Q is trifluoromethanesulfonate or r = 0 and Q' is trifluoromethanesulfonate may be obtained according to the procedure described in Arcadi, A. et al. Eur. J. Org. Chem. 1999, 3117-3126, or Liu, X. et al. in Org. Lett. 2003, 5, 1915-1918, or according to any conventional methods known to the man skilled in the art
Compounds (XFV) are commercially available or may be synthetized as shown in Scheme 11, from intermediates (XIVa), according to conventional methods known to the man skilled in the art.
In intermediates (XIV) and (XIVa):
-X is a halogen atom, preferably a halogen atom different from fluorine;
- Al, R1 and R^ as defined in general formula (I);
- R4' is R4 as defined above in the specification for compounds of formula (I); or is -O-(CH2)n-Cl or hydroxy or O-CH2-Phenyl. When R4' is C1.4 alkoxy, it is preferably a methoxy;
- R5' is R^ as defined above in the specification for compounds of formula (I); or - O-(CH2)m-Cl or hydroxy or C 1.4 alkoxy or O-CH2-Phenyl or a chlorine atom. When R^' is C}_4 alkoxy, it is preferably a methoxy;
Figure imgf000056_0001
Scheme 11
Preferably, compounds (XIVa) react with a boron reagent, such as bis(pinacolato)diboron in the presence of a palladium-based catalyst to provide intermediates (XIV) according to method described by Ishiyama, T. et al. in J. Org. Chem. 1995, 60, 7508.
Compounds (Id) wherein A^ is an oxygen or a sulfur atom, R*0 is -(CH2)W- (C=O)^-NRI 5R16} W is equal to 1, and t is equal to 0 may be obtained from intermediates (XIII), Q is a halogen atom, preferably Cl or Br and R4' is OH or -0-(CE^)n-Cl, or R5' is -OH or -O-(CH2)n-Cl according to Scheme 12.
Figure imgf000057_0001
Scheme 12
Hereafter, reference is made respectively to steps (xiii), (xiv) and (xv) of Scheme
12:
-Step (xiii): intermediates (XIII) are reacted with HNR15R16 in the presence of a base, such as triethylamine, to afford intermediates (XIIIa), wherein R.4' or R5' is - OH. Alternatively, intermediates (XIII) may react with HNR15R16 wherein R15 and R16 are linked together to form a C^-β alkylene, one methylene of the alkylene being optionally replaced by a carbonyl, such as pyrrolidone in the presence of a base such as sodium hydride in a solvent such as dimethylformamide to afford intermediate (XIIIa).
-Step (xiv): intermediates (XIIIa) are converted to intermediates (XIIIb) wherein
R4' is -O-(CH2)n-Cl or R5' is -O-(CH2)m-Cl according to conventional methods known to the man skilled in the art or according to conditions described for step (iiib) of Scheme 15. -Step (xv): intermediates (XIIIb) are reacted with HNR12aR12b or HNR13aR13b according to reaction conditions described for step (iiic) of Scheme 15.
Additionally, compound of formula (XIII) wherein Q = H, et w = 1 and R1 1 = CO2R, may be treated with a halogen-releasing agent such as N-bromosuccinimide or N- chlorosuccinimide to afford compounds of formula (XIII) wherein Q = Cl or Br and w = 1. Compounds of formula (XIII) in Scheme 12, wherein w= 1; Q is halogen (except fluorine); or compounds of formula (XHIbis) in Scheme 12bis, wherein w=l; Q' is halogen (except fluorine), all other groups of (Id) as defined in the general formula, may also be transformed into compounds (Id), wherein RlO is C\ _g alkyl sulfanyl, according to methods described in WO 03/097047.
Alternatively, compounds (Id) wherein A^ is an oxygen or a sulfur atom, Rl 1 is -
Figure imgf000058_0001
r js eqUai to 1, and z is equal to 0 may be obtained from intermediates (XHIbis) wherein Q' is a halogen atom, preferably Cl or Br, and R4' is OH or -O-(CH2)n-Cl, or R5' is -OH or -O-(CH2)n-Cl, according to Scheme 12bis. Reference made for step (xiii), (xiv and (xv) in Scheme 12 here above may be applied accordingly to Scheme 12bis.
Figure imgf000058_0002
Scheme 12bis
Alternatively, compounds (Id) wherein A^ is oxygen or sulfur, RIO is -(CH2)W-
Figure imgf000058_0003
w is equal to 1 or 2 and t is equal to 0 may be obtained from intermediates (XIII) wherein Q = COOR' and R4' is -O-(CH2)n-Cl or R5' is -O-(CH2)m- Cl according to Scheme 13.
Figure imgf000059_0001
(Id)
Scheme 13
Hereafter, reference is made respectively to steps (xvi), (xvii), (xviii), (xix) and (xx) of Scheme 13.
- Step (xvi): intermediates (XIII) are reacted with HNR12aR12b or HNR13aR13b to afford intermediates (XIIIc) wherein R.4' or R^' is respectively R^ or R^ as defined in general formula (I).
- Step (xvii): intermediates (XIIIc) are hydrolysed to provide the corresponding acid intermediates (XIIId), according to conventional methods known to the man skilled in the art.
- Step (xviii): intermediates (XIIId) are reacted with HNR15R16 m the presence of a coupling agent, such as l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and an activating agent, such as 1-hydroxy-benzotriazole, according to conventional methods known to the man skilled in the art, to afford compounds (XIIIe) in which preferably w is equal to 0 or 1, and t is equal to 1.
- Step (xix): compounds (XIIIe) are converted to intermediates (XIIIf) using reaction conditions described in step (iii) of Scheme 15, depending on the nature of R4' and R5\ Step (xx): intermediates (XIIIf) are reacted with a reducing agent according to conventional methods known to the man skilled in the art to afford compounds (Id).
Alternatively, compounds (Id) wherein A^ is oxygen or sulfur, R^ 1 is -(CH2)r- (C=O)2-NRI TRI 8, r 1S equal to 1 or 2 and z is equal to 1 may be obtained from intermediates (XHIbis) wherein Q' = COOR' and R4' is -O-(CH2)n-Cl or R5' is -O- (CH2)m-Cl according to Scheme 13bis. Reference made respectively to steps (xvi), (xvii), (xviii), (xix) and (xx) of Scheme 13 maybe applied to Scheme 13bis.
Figure imgf000060_0001
Schema 13bis
In some cases, depending on the nature of the R4' and R^' groups, intermediates (XIIIe) may correspond to compounds (Id), wherein in RlO, w is equal to 0 or 1 and t is equal to 1.
In a similar manner, intermediates (Xlllebis) may correspond to compounds (Id), wherein in R* 1, r is equal to 0 or 1 and z is equal to 1.
Compounds of formula (Id), wherein R^ is Cj. β alkyl sulfonyl, C\_β alkyl sulfinyl, may be obtained by reacting compounds (Id), wherein R^ 1 is C\_β alkyl sulfanyl, using an oxidizing agent in stoechiometric or excess amount, such as m-chloroperbenzoic acid, according to Brown, TJ. et al. in J. Med. Chem. 1992, 35, 3613-3624 or any methods known to the man skilled in the art.
Compounds of formula (Id), wherein R11 is C\ _g alkyl aminosulfonyl or C\.β aryl aminosulfonyl may be obtained by the reaction of compound (Id) wherein R^ 1 is an amino group with a C\.β alkyl sulfonyl chloride or C1-6 aryl sulfonyl chloride according to conventional methods known to the man skilled in the art. Compounds (Id) wherein R1^ is Cj _ 6 alkyl aminosulfonyl or C\.β aryl aminosulfonyl may be obtained in a similar manner, according to Hulin, B. et al. in J. Med. Chem.1992, 35, 1853-1864.
F. According yet to another embodiment of the present invention, compounds of general formula (I), hereafter referred to as compounds (Ie) and unless otherwise specified:
- R1, R3, R12a, R12b, R13a, R13b, A1 and A3, r and z, and provisos are as defined for compounds of general formula (I);
- R4' is -O-(CH2)n-Cl or R5' is -O-(CH2)m-Cl or a chlorine atom; - R10 is Ci_4 alkyl. Preferably, R10 is a methyl;
- R1 Us -CH2-NR17R18; may be obtained after several reaction steps starting from compounds (XHIbis) wherein Q' = COOR', r is equal to 0 and z is equal to 1, R4' is -O-(CH2)n-Cl or R5' is -O- (CH2)m-Cl, as shown in Scheme 14.
In Scheme 14, R' is
Figure imgf000061_0001
alkyl, preferably a methyl and X is a halogen atom, preferably a chlorine or bromine atom.
Figure imgf000061_0002
Scheme 14 Hereafter, reference is made respectively to steps (xxi), (xxii) and (xxiii) of Scheme 14.
- Step (xxi): intermediates (XHIbis) are reacted with a reducing agent, such as lithium borohydride, according to conventional methods known to the man skilled in the art, to afford intermediate (XIX).
- Step (xxii): alcohols of formula (XIX) are reacted with methanesulfonyl chloride in the presence of a base, and then reacted with EGSTR ^R ^ according to conventional methods known to the man skilled in the art to afford intermediate
(XX).
Alternatively, alcohols of formula (XIX) are reacted with amide of formula HNR17R18S wherein Rl^ and Rl 8 are linked together to form a C3.6 alkylene, one methylene of the alkylene adjacent to the nitrogen being replaced by a carbonyl, such as in pyrrolidone in the presence of para-tohxene sulfonic acid in a solvent such as toluene to afford intermediate (XX).
- Step (xiii): intermediates (XX) are subsequentely reacted with HNRl2aRl2b or
HNRl^3Rl 3b to afford compounds (Ie), according to conditions described for step
(xvi) above in the specification.
Preferably, reactions represented in Scheme 14 are applied to compounds of formula (XI) wherein A1 is CH.
According yet to another embodiment of the present invention, compounds of general formula (Id) could be obtained from compounds (XIII) as described in Scheme 15.
Figure imgf000062_0001
Scheme 15
Conversion of compounds of formula (XIII) into compounds of formula (Id), may occur in one or more steps, under a variety of reaction conditions depending on the nature of R^', R-*', A^ and Q groups, according to conditions described hereafter in steps (iiia), (iiib), (iiic), (iiid) and (iiie):
- Step (iiia): intermediates of formula (XIII) wherein A* is CH and R4' or R.5' is - O-CH2-phenyl may be converted to intermediates of same general formula as intermediates (XIII) wherein R4' or R^' is -OH, using a catalyst, for example palladium on charcoal (Pd/C or Pd(OH)2/C), in the presence of a solvent such as methanol or ethanol under a hydrogen atmosphere.
- Step (iiib): intermediates (XIII) wherein A* is CH and R4' or R^' is OH may be converted into intermediates (XIII), wherein A^ is CH and R4' is -O-(CH2)n-Cl or R5 ' is -O-(CH2)m-Cl by reacting with a di-haloalkane respectively of general formula -Y-(C^)n-Cl or Y-(CH2)m-Cl, wherein Y is a halogen except a fluorine, in the presence of a base. Preferably, Y is a bromine atom. This reaction may occur according to methods described by Walsh et al. in J. Med.Chem. 1989, 32, 105.
- Step (iiic): intermediates (XIII) wherein A1 is CH and R4' is -O-(CH2)n-Cl or R5' is -O-(CH2)m-Cl may react respectively with HNR12aR12b or with HNR13aR13b in the presence of a base such as triethylamine or potassium carbonate in acetonitrile or acetone as solvent, to afford compounds of formula (Id). The reaction may be performed according to conventional methods known to the man skilled in the art.
- Step (iiid): intermediates (XIII), wherein A^ is a nitrogen atom, and R4' or R->' is a halogen atom, preferably a chlorine or a bromine atom, are reacted respectively with amino alcohols of formula HO-L, L being as defined here above in the specification, preferably with amino alcohols of formula HO-(CH2)n-NRl2aR.l2b or HO-(CH2)m-NR^aRl3b, to afford compound (Id) according to conventional methods known to the man skilled in the art. Alternatively a base, such as potassium tert-butylate, cesium carbonate or sodium hydride, with a solvent, such as dimethylformamide or tetrahydrofuran, in the presence of a palladium- or a copper- based catalyst, may be added, according to methods described by Penning et al. in J. Med. Chem. 2000, 43,721.
- Step (iiie): intermediates (XIII), wherein A* is CH, and R4' or R^' is a hydroxy group, are reacted respectively with amino alcohols of formula HO-L, L being as defined here above in the specification, preferably with amino alcohols of formula HO-(CH2)n-NR12aR12b or HO-(CH2VNR^RlSb5 to afford compound (Id) according to conventional methods known to the man skilled in the art. Alternatively, diethylazodicarboxylate in the presence of triphenylphosphine in a solvent such as dichloromethane may be used.
Alternatively, compounds of general formula (Id) may be obtained from compound
(XHIbis) follwing steps (iiia), (iiib), (iiic), (ϋid) and (iiie) described in Scheme 15.
G. According yet to another embodiment of the present invention, compounds of general formula (I), hereafter referred to as compounds (Id) and unless otherwise specified:
- Rl, R3, R12a, R12b, R13a, R13b, A1 and A3, r and z, and provisos are as defined for compounds of general formula (I); - R4' is -O-(CH2)n-Cl or R5' is -O-(CH2)m-Cl or a chlorine atom;
- R10 is -CH2-NR15R16;
- R1 i is H or Ci _4 alkyl. Preferably, R11 is a methyl; may be obtained after several reaction steps starting from compounds (XIII) wherein Q is a hydroxy group or chlorine atom, w is equal to 0, R4' is -O-(CH2)n-Cl or R5 ' is -O-(CH2)m-Cl, as shown in Scheme 16.
Figure imgf000064_0001
Scheme 16
Hereafter, reference is made respectively to steps, (xxiv), (xxv) and (xxvi) of Scheme 16: - Step (xxiv): intermediated (XIII), wherein Q is a hydroxy group are reacted with an oxidizing agent, according to conventional methods known to the man skilled in the art, to afford intermediates of formula (XXI). Alternatively, intermediates of formula (XIII), wherein Q is a chlorine atom, may react with anhydrous trimethylamine N- oxide in a mixture of solvent such as dichloromethane and dimethylsulfoxide, to afford intermediates or formula (XXI).
- Step (xxv): compounds of formula (XXI) are reacted with HΝR.1%16 in the presence of a reducing agent, such as sodium cyanoborohydride in a solvent such as tetrahydrofuran, according to conventional methods known to the man skilled in the art to afford intermediate (XIIIa).
- Step (xxvi): intermediates (XIIIa) are subsequentely reacted with HNR.12aRl2b or HNR 13aRl 3b to afford compounds (Id), according to conditions described for step (iii) above in Scheme 15.
Unless otherwise specified, preferred groups, more preferred and most preferred R*, R2, R3, R4 R5} RlO9 R11; R12a R12b, R13a R13b R15, R165 RH R18 ^0Up8 of compounds represented in Schemes 9 to 16 are as defined above in the specification for compounds of general formula (I).
H. According to another embodiment, some compounds of general formula (I) may be prepared by functional group transformation.
Compounds of general formula (If) may be obtained from intermediates (XIII), wherein A^, A3, RI, R2, R3? R4'5 R5' W an(j t are defined above in the specification for compounds of formula (I), Q is Cl, Rl 1 is a hydrogen, according to step (xxvii) in Scheme 17.
Figure imgf000065_0001
Scheme 17 Hereafter, reference is made to step (xxvii) of Scheme 17;
Step (xxvii): compounds of formula (XIII) are reacted with a halide-releasing agent, such as N-bromosuccinimide in a solvent, such as acetonitrile, to afford compounds of formula (If). In a particular embodiment, the present invention relates to a compound of formula (VII), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000066_0001
wherein AUs CH5 C(CHS) OrN; A2 is O or S;
Y" is halogen, hydroxy or C 1.4 alkoxy;
RI is hydrogen or halogen;
R3 is hydrogen, halogen, C 1.4 alkyl or C].4 alkoxy;
R4' is hydrogen, halogen, C 1.4 alkyl, C\ .4 alkoxy, O-CH2-Phenyl; or -O-(CH2)n- Cl or -O-(CH2)n-NR12aR12b;
R5' is hydrogen, halogen, -O-CH2-Phenyl, -O-(CH2)m-Cl or -O-(CH2)m- NR13aR13b, each CH2 in -O-(CH2)m-NR13aR13b being optionally substituted by one or two Ci .4 alkyl;
R^2a and R^2b are linked together to form a C^- -β alkylene, each methylene of the alkylene being optionally substituted by a Ci .4 alkyl;
Rl3a and R*3b are linked together to form a C3_g alkylene, each methylene of the alkylene being optionally substituted by a Cj .4 alkyl, an amino group or C1-6 alkyl amino, one methylene of the alkylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Ci _g alkyl or Ci _g alkyl amino; n and m are independently an integer comprised between 2 and 8; with the proviso that R4' is -0-(CH2)H-NR12aR12b, -O-(CH2)n-Cl, Or-O-CH2-
Phenyl when R5' is hydrogen and that R5' is -O-(CH2)m-NR13aR13b, -O-(CH2)m-Cl, or -O-CH2-Phenyl when R^' is hydrogen, halogen, Ci .4 alkyl or Cj.4 alkoxy; and with the proviso that said compound of formula (VII) is different from methyl 4-(3- chloropropoxy)benzoate, 4-(3-chloropropoxy)benzoic acid, 4-(3- chloropropoxy)benzoylchloride, methyl 3-(3-chloropropoxy)benzoate, methyl 4-(3- piperidin-l-ylpropoxy)benzoate, methyl 3-(3-piperidin-l-ylpropoxy)benzoate, methyl 4-(3- pyrrolidin-l-ylpropoxy)benzoate), 4-(3-piperidin-l-ylpropoxy)benzoic acid and 4-(3- pyrrolidin-l-ylpropoxy)benzoic acid.
Preferably, A1 is CH or C(CEB). More preferably, A1 is CH.
Preferably, A2 is O.
Y" is preferably a hydroxy, a chlorine atom or a methoxy.
hi a further particular embodiment, the present invention relates to a compound of formula (XI), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000067_0001
AUs CH5 C(CH3) OrN;
A3 is O or S;
RI is hydrogen or halogen;
R3 is hydrogen, halogen, C i_4 alkyl or C\ .4 alkoxy;
R4' is hydrogen, halogen, Cj .4 alkyl, C\ .4 alkoxy, hydroxy, -O-CH2-Phenyl; -O- (CH2)n-Cl or -O-(CH2)n-NR12aR12b;
R^' is hydrogen, halogen, C\ .4 alkoxy, hydroxy, -O-CH2-Phenyl, -O-(CH2)m-Cl or -0-(CH2)J11-NR13aR13b, each CH2 in -O-(CH2)m-NR13aR13b being optionally substituted by one or two C 1.4 alkyl;
Rl2a and Rl2b ace linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by a C^ .4 alkyl;
Ri 3a and Rl3b are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by a Cj .4 alkyl, an amino group or C\.β alkyl amino, one methylene of the alkylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C1-6 alkyl amino; n and m are independently an integer comprised between 2 and 8; with the proviso that R4' is -O-(CH2)n-NR12aR12b, -O-(CH2)n-Cl, or -0-CH2- Phenyl when R5' is hydrogen and that R5' is -O-(CH2)m-NR13aR13b, -O-(CH2)m-Cl, or -O-CH2-Phenyl when R4' is hydrogen, halogen, C \.4 alkyl or C\ .4 alkoxy; and with the proviso that said compound of formula (XI) is different from 4-(3- chloropropoxy)benzamide and 4-(2-chloroethoxy)benzamide.
Preferably, A1 is CH or C(CHS). More preferably, A1 is CH. Preferably, A3 is O.
When R5' is halogen, it is preferably a chlorine atom. When R4 is a Cj .4 alkoxy, it is preferably a methoxy.
In a particular embodiment, the present invention relates to a synthetic intermediate of formula (XIII) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000068_0001
(Xm)
wherein
A1 is CH, C(CH3) or C-halogen;
A3 is O or S;
Q is hydrogen, COOR', -(C=O)1-NR15R16 or halogen; R' is hydrogen or Cj .4 alkyl; Rl is hydrogen, halogen or C 1.4 alkyl;
R3 is hydrogen;
R4' is hydrogen, halogen, C 1.4 alkyl, Cj .4 alkoxy or -O-(CH2)n-Cl. R5' is hydrogen, hydroxy, -O-(CH2)m-halogen, -O-CH2-Phenyl, or -0-(CH^)1n- NRl3aRl3b;
R1 ! is hydrogen, C 1.4 alkyl, halogen or -(CB^V(C=O)2-NR17R18; Rl3a an(i Rl3b aτe Jinked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl, an amino group or C\.§ alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Ci_8 alkyl, C3.6 cycloalkyl or C\.β alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a €3.5 alkylene. R15 is hydrogen or a C \ _g alkyl;
R!6 is aryl, heteroaryl, Cj.g alkyl, C\_β alkyl cycloalkyl, C3_g cycloalkyl, C\_β alkyl aryl or a CH2- heteroaryl; or R15 and R1^ are linked together to form a C^.β alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by C \ _g alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C3_g cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3..8 cycloalkyl or a carbonyl and another methylene being optionally substituted by an alkylamine; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a
Figure imgf000069_0001
alkylene; or R15 and R16 are linked together to form with N an unsaturated 5- or 6-membered heteroaryl optionally substituted by a C\_ 4 alkyl; R17 is hydrogen or a C^.g alkyl;
R! ° is Ci_g alkyl, C1-6 alkyl cycloalkyl or C\.β alkyl aryl; or RI 7 and Rl 8 are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl or C3.6 cycloalkyl; w is an integer equal to 0 or 1 ; t is an integer equal to 0 or 1 ; z is an integer equal to 0 or 1; and m is an integer equal to 2, 3 or 4; and provided that when R5' is O-CH2-Phenyl, R4' is halogen and that compound (XIII) is different from 4-(2-oxazolylphenol), 4-(4-chloromethyl- oxazol-2-yl)phenol; 4-(4-chloromethyl-thiazol-2-yl)phenol, ethyl 2-(4- hydroxyphenyl)oxazole-4-carboxylate, 2-(4-hydroxy-phenyl)-4-[2-(methoxycarbonyl)- ethyl]-l,3-thiazole; 4-(5-ethyl-2-thiazolyl)phenol and 4-(4-methyl-oxazol-2-yl)phenol.
In a another particular embodiment the present invention relates to a synthetic intermediates of formula (XHIbis), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000070_0001
(Xπibis)
wherein
A1 is CH or N;
A3 is O or S;
Q' is hydrogen, COOR', halogen or -(C=O)2-NR17R18;
R' is hydrogen or Cj „4 alkyl; R1 is hydrogen;
R3 is hydrogen; R4' is hydrogen;
R5' is hydrogen, halogen, -O-(CH2)m-halogen or -O-(CH2)m-NR13aR13b; R10 is Ci_4 alkyl or -(C=O)1-NR15R1^; R13a and R13° are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C\ .4 alkyl, an amino group or C1-6 alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl, Cj-β cycloalkyl or C\.β alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C-^.β alkylene.
R.15 is hydrogen or a C i_g alkyl; R.16 is aryl, a heteroaryl, Ci_g alkyl, C3. g cycloalkyl, C1-6 alkyl cycloalkyl, Cj_g alkyl aryl or a CH2- heteroaryl; or R!5 and R^ are linked together to form a C^-β alkylene, each methylene of the alkylene being optionally substituted by one or two C \j\. alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by C1-6 alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C\_ g alkyl or C3.6 cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3_g cycloalkyl or a carbonyl and another methylene being optionally substituted by an alkylamine; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C3_g alkylene; or R^ and R^ are linked together to form with N an unsaturated 5- or 6-membered heteroaryl optionally substituted by a Cj .4 alkyl; R!7 is hydrogen or a Cj.g alkyl;
R!8 is C}_g alkyl, C1-6 alkyl cycloalkyl or C\.β alkyl aryl; or R!7 and R^ are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cμg alkyl or C3..6 cycloalkyl; t is an integer equal to 0 or 1; m is an integer equal to 2, 3 or 4; z is an integer equal to 0 or 1; and r is an integer equal to 0 or 1.
In a further particular aspect, the present invention relates to compounds of formula (Id),
Figure imgf000072_0001
(Id)
wherein, Al, A^, Rl, R^5 R4S R5? R10? RI 1 ^j provisos are as defined above in the specification for compounds of formula (I). In yet another further particular aspect, the present invention relates to compounds of formula (Ie),
Figure imgf000072_0002
(Ie)
wherein, Al, A^, RI, R3, R4S R5? RIO^ R175 R18 an^ provisos are as defined above in the specification for compounds of formula (I).
hi a further embodiment, the invention relates to a synthetic intermediate selected from the group consisting of
4-(4-chlorobutoxy)benzamide; 3-(3-chloropropoxy)benzamide;
4-(3-chloropropoxy)benzenecarbothioamide;
4-(chloromethyl)-2-[4-(3 -chloropropoxy)phenyl] -1,3 -oxazole;
2-[4-(2-chloroethoxy)phenyl]-4-(chloromethyl)-l,3-oxazole;
2-[4-(4-chlorobutoxy)phenyl]-4-(chloromethyl)-l,3-oxazole; methyl {2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}acetate;
{2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}acetic acid;
2-[4-(3-chloropropoxy)phenyl]-4-(2-oxo-2-pyrrolidin-l-ylethyl)-l,3-oxazole;
4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2-yl}phenol;
2-[4-(3-chloropropoxy)phenyl]-4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazole; 2-[4-(2-chloroethoxy)phenyl]-4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazole;
2-[4-(4-chlorobutoxy)phenyl]-4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazole;
4-(chloromethyl)-2-[3-(3-chloropropoxy)phenyl]-l,3-oxazole;
4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-thiazole; {2-[4-(3-chloropropoxy)phenyl]-4-methyl- 1 ,3-oxazol~5-yl}methanol; methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl- 1 ,3-oxazole-5-carboxylate; l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}acetyl)piperidine;
2- {2-[4-(3 -chloropropoxy)phenyl] - 1 ,3 -oxazol-4-yl } -N-(4-fluorophenyl)acetamide;
4-( {2-[4-(3-chloropropoxy)phenyl]- 1 ,3-oxazol-4-yl} acetyl)moφholine; 2- {2-[4-(3 -chloropropoxy)phenyl] - 1 ,3 -oxazol-4-yl } -N-cyclopentylacetamide;
2-{2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}-N-(cyclopropylmethyl)-N- propylacetamide; l-( {2-[4-(3-chloropropoxy)phenyl]- 1 ,3-oxazol-4-yl} acetyl)azepane;
2- [4-(3 -chloropropoxy)phenyl] -4, 5-dimethyl- 1 ,3 -oxazole; 4-(bromomethyl)-2-[4-(3 -chloropropoxy)phenyl]-5-methyl- 1 ,3-oxazole;
4-(bromomethyl)-2- [4-(3 -bromopropoxy)phenyl] -5 -methyl- 1 ,3-oxazole; ethyl 2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-4-carboxylate;
2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-4-carboxylic acid;
4-( {2-[4-(3-chloropropoxy)phenyl]- 1 ,3 -oxazol-4-yl} carbonyl)moφholine; l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}carbonyl)piperidine;
1 -( {2-[4-(3-chloropropoxy)phenyl]- 1 ,3 -oxazol-4-yl} carbonyl)-4- cyclopentylpiperazine;
2-[4-(3-chloropropoxy)phenyl]-N-(cyclopropylmethyl)-N-propyl-l,3-oxazole-4- carboxamide; 2-[4-(3-chloropropoxy)phenyl]-N-cyclopentyl-l,3-oxazole-4-carboxamide;
2-[4-(3-chloropropoxy)phenyl]-N-(4-fluorobenzyl)-l,3-oxazole-4-carboxaniide;
2-[4-(3-chloropropoxy)phenyl]-4-(pyrrolidin- 1 -ylcarbonyl)- 1 ,3-oxazole;
2-[4-(3-chloropropoxy)phenyl]-4- {[(2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 - yl]carbonyl} - 1 ,3-oxazole; 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5-carboxylic acid;
2-[4-(3-chloroproρoxy)phenyl]-N-(cyclopropylmethyl)-4-methyl-N-propyl-l,3- oxazole-5-carboxamide;
1 -( {2-[4-(3-chloropropoxy)phenyl]-4-methyl- 1 ,3-oxazol-5-yl}carbonyl)piperidine; l-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazol-5-yl}carbonyl)-4- cyclopentylpiperazine;
N-benzyl-2-[4-(3-chloropropoxy)phenyl]-4-metliyl-l,3-oxazole-5-carboxamide;
4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazol-5-yl}carbonyl)moφholine; 2-[4-(3-chloropropoxy)phenyl]-N-cyclopentyl-4-methyl-l,3-oxazole-5- carboxamide; methyl [2-(4-hydroxyphenyl)-l,3-oxazol-4-yl]acetate; methyl {2-[4-(2-chloroethoxy)phenyl]-l,3-oxazol-4-yl}acetate; methyl (2- {4-[2-(2-methylpyrrolidin- 1 -yl)ethoxy]phenyl} - 1 ,3-oxazol-4-yl)acetate; (2- {4-[2-(2-methylpyrrolidin- 1 -yl)ethoxy]phenyl} - 1 ,3-oxazol-4-yl)acetic acid; l-[(2- {4-[2-(2-methylpyrrolidin- 1 -yl)ethoxy]phenyl} - 1 ,3-oxazol-4- yl)acetyl]piperidine; l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)piperidin-2-one;
(5S)-l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)-5-(pyrrolidin-l- ylmethyl)pyrrolidin-2-one;
(5S)-l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)-5-(moφholin-4- ylmethyl)pyrrolidin-2-one; l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)pyrrolidin-2-one;
(2-chloro- 1 ,3 -oxazol-4-yl)methyl methanesulfonate; 1 - [(2-chloro- 1 ,3 -oxazol-4-yl)methyl]piperidine; l-({2-[4-(benzyloxy)-3-chlorophenyl]-l,3-oxazol-4-yl}methyl)piperidine; l-({2-[4-(benzyloxy)-3-fluorophenyl]-l,3-oxazol-4-yl}methyl)piperidine;
2,6-dimethyl-4-[4-(piperidin- 1 -ylmethyl)- 1 ,3-oxazol-2-yl]phenol;
2-methoxy-4-[4-(piperidin- 1 -ylmethyl)- 1 ,3-oxazol-2-yl]phenol; 2-chloro-4-[4-(piperidin- 1 -ylmethyl)- l,3-oxazol-2-yl]phenol;
2-fluoro-4-[4-(piperidin- 1 -ylmethyl)- 1 ,3 -oxazol-2-yl]phenol; l-({2-[3-chloro-4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)piperidine; l-({2-[4-(3-chloropropoxy)-3,5-dimethylphenyl]-l,3-oxazol-4- yl } methyl)piperidine ; l-({2-[4-(3-chloropropoxy)-3-fluorophenyl]-l,3-oxazol-4-yl}methyl)piperidine;
1 -( {2-[4-(3-chloropropoxy)-3 -methoxyphenyl]- 1 ,3 -oxazol-4-yl} methyl)piperidine;
3-chloropropyl 4-(3-chloropropoxy)-2-fluorobenzoate;
3-chloropropyl 4-(3 -chloropropoxy)-2-methylbenzoate;
3 -chloropropyl 4-(3 -chloropropoxy)-3 ,5 -difluorobenzoate; 4-(3-chloropropoxy)-2-fluorobenzoic acid;
4-(3-chloropropoxy)-2-methylbenzoic acid;
4-(3 -chloropropoxy)-3 ,5 -difluorobenzoic acid;
4-(3-chloropropoxy)-2-fluorobenzoyl chloride; 4-(3-cliloropropoxy)-2-methylbenzoyl chloride;
4-(3-chloropropoxy)-3,5-difluorobenzoyl chloride;
4-(3-chloropropoxy)-2-fluorobenzamide;
4-(3-chloropropoxy)-2-methylbenzamide;
4-(3 -chloropropoxy)-3 ,5 -difluorobenzamide; 4-(chloromethyl)-2-[4-(3-chloropropoxy)-2-fluorophenyl]- 1 ,3-oxazole;
4-(chloromethyl)-2-[4-(3-chloropropoxy)-2-methylphenyl]-l,3-oxazole;
4-(chloromethyl)-2-[4-(3-chloropropoxy)-3,5-difluorophenyl]-l,3-oxazole; l-({2-[4-(3-chloropropoxy)-2-fluorophenyl]-l,3-oxazol-4-yl}methyl)piperidine; l-({2-[4-(3-chloropropoxy)-2-methylphenyl]-l,3-oxazol-4-yl}methyl)piperidine; l-({2-[4-(3-chloropropoxy)-3,5-difluorophenyl]-l,3-oxazol-4-yl}methyl)piperidine;
2- [4-(3 -chloropropoxy)phenyl] - 1 ,3 -thiazole;
5-bromo-4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole; l-({5-bromo-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)piperidine; methyl 2-[3-bromo-4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5- carboxylate; methyl 4-(bromomethyl)-2-[4-(3-chloropropoxy)phenyl]- 1 ,3-oxazole-5-carboxylate; ethyl 4-(bromomethyl)-2-[4-(3-chloropropoxy)phenyl]- 1 ,3-oxazole-5-carboxylate; methyl 4-[(benzylamino)methyl]-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-5- carboxylate; ethyl 2-[4-(3-chloropropoxy)phenyl]-4-(piperidin-l-ylmethyl)-l,3-oxazole-5- carboxylate; ethyl 2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } -4-(piperidin- 1 -ylmethyl)- 1 ,3-oxazole-5-carboxylate; ethyl 2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazole-5-carboxylate; 2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazole-5-carboxylic acid;
4-{[2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazol-5-yl]carbonyl}morpholine;
2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-4-carbaldehyde;
N-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)-2-methyl-2H-tetrazol- 5-amine; ethyl {2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}acetate;
{2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}acetic acid; l-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}acetyl)piperidine; methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl- 1 ,3-thiazole-5-carboxylate; 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5-carboxylic acid;
4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}carbonyl)moφholine;
1 -( {2-[4-(3-chloropropoxy)phenyl]-4-methyl-l ,3-thiazol-5-yl} carbonyl)-4,4- difluoropiperidine;
{2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}methanol; and l-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}methyl)pyrrolidin-2- one.
In a particular embodiment, the present invention relates to the use of a synthetic intermediate of formula (XIII) or (XHIbis) for the preparation of compound of formula (I).
It has now been found that compounds of formula (I) according to the present invention and their pharmaceutically acceptable salts are useful in a variety of medical disorders.
For example, the compounds according to the invention are useful for the treatment and prevention of diseases or pathological conditions of the central nervous system including mild-cognitive impairment, Alzheimer's disease, learning and memory disorders, cognitive disorders, attention deficit disorder, attention-deficit hyperactivity disorder,
Parkinson's disease, schizophrenia, dementia, depression, epilepsy, seizures, convulsions, sleep/wake disorders, narcolepsy, and/or obesity.
Furthermore, compounds according to the invention alone or in combination with an antiepileptic drug (AED) may be useful in the treament of epilepsy, seizure or convulsions. It is known from literature that the combination of H3 -receptor ligands with an AED may produce additive synergistic effects on efficacy with reduced side-effects such as decreased vigilance, sedation or cognitive problems.
Furthermore, compounds of general formula (I) alone or in combination with a histamine Hj-receptor antagonist may also be used for the treatment of upper airway allergic disorders.
In a particular embodiment of the present invention, compounds of general formula
(I), alone or in combination with muscarinic receptor ligands and particularly with a muscarinic M2-receptor antagonist, may be useful for the treatment of cognitive disorders,
Alzheimer's disease, and attention-deficit hyperactivity disorder. Particularly, compounds of general formula (I) displaying NO-donor properties, alone or in combination with a nitric oxide (NO) releasing agent may be useful in the treatment of cognitive dysfunctions.
Compounds of general formula (I) may also be used in the treatment of sleep/wake and arousal/vigilance disorders such as hypersomnia, and narcolepsy.
Usually, compounds of general formula (I) may be used in the treatment of all types of cognitive-related disorders.
Preferably, compounds of general formula (I) may be used for the treatment of cognitive dysfunctions in diseases such as mild cognitive impairment, dementia, Alzheimer's disease, Parkinson's disease, Down's syndrome as well as for the treatment of attention-deficit hyperactivity disorder. hi another preferred embodiment, compounds of general formula (I) may also be used for the treatment of psychotic disorders, such as schizophrenia; or for the treatment of eating disorders, such as obesity; or for the treatment of inflammation and pain; or for the treatment of anxiety, stress and depression; or for the treatment of cardiovascular disorders, for example, myocardial infarction.
In a further aspect, compounds of formula (I) according to the present invention may be used as a medicament. hi a particular embodiment, the present invention concerns the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof or of a pharmaceutical composition comprising an effective amount of said compound for the manufacture of a medicament for the treatment and prevention of mild-cognitive impairement, Alzheimer's disease, learning and memory disorders, attention-deficit hyperactivity disorder, Parkinson's disease, schizophrenia, dementia, depression, epilepsy, seizures, convulsions, sleep/wake disorders, cognitive dysfunctions, narcolepsy, hypersomnia, obesity, upper airway allergic disorders, Down's syndrome, anxiety, stress, cardiovascular disorders, inflammation and pain.
Preferably, the present invention concerns the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising an effective amount of said compound for the manufacture of a medicament for the treatment of cognitive dysfunctions in diseases such as mild cognitive impairment, dementia, Alzheimer's disease, Parkinson's disease, Down's syndrome as well as for the treatment of attention-deficit hyperactivity disorder. The methods of the invention comprise administration to a mammal (preferably human) suffering from above mentioned conditions or disorders, of a compound according to the invention in an amount sufficient to alleviate or prevent the disorder or condition.
The compound is conveniently administered in any suitable unit dosage form, including but not limited to one containing 3 to 3000 mg of active ingredient per unit dosage form.
The term "treatment" as used herein includes curative treatment and prophylactic treatment.
By "curative" is meant efficacy in treating a current symptomatic episode of a disorder or condition.
By "prophylactic" is meant prevention of the occurrence or recurrence of a disorder or condition.
The expression "cognitive disorders" as used herein refers to disturbances of cognition, which encompasses perception, learning and reasoning or in other terms the physiological (mental/neuronal) process of selectively acquiring, storing, and recalling information.
The expression "attention-deficit hyperactivity disorder" (ADHD) as used herein refers to a problem with inattentiveness, over-activity, impulsivity, or a combination of these. For these problems to be diagnosed as ADHD, they must be out of the normal range for the child's age and development. The term "attention-deficit disorder" (ADD) is also commonly used for the same disorder.
The expression "Alzheimer's disease" (AD) as used herein refers to a progressive, neurodegenerative disease characterized in the brain by abnormal clumps (amyloid plaques) and tangled bundles of fibers (neurofibrillary tangles) composed of misplaced proteins. Age is the most important risk factor for AD; the number of people with the disease doubles every 5 years beyond age 65. Three genes have been discovered that cause early onset (familial) AD. Other genetic mutations that cause excessive accumulation of amyloid protein are associated with age-related (sporadic) AD. Symptoms of AD include memory loss, language deterioration, impaired ability to mentally manipulate visual information, poor judgment, confusion, restlessness, and mood swings. Eventually AD destroys cognition, personality, and the ability to function. The early symptoms of AD, which include forgetfulness and loss of concentration, are often missed because they resemble natural signs of aging. The expression "Parkinson's disease" (PD) as used herein refers to a group of conditions called motor system disorders, which are the result of the loss of dopamine- producing brain cells. The four primary symptoms of PD are tremor, or trembling in hands, arms, legs, jaw, and face; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks. PD usually affects people over the age of 50. Early symptoms of PD are subtle and occur gradually. In some people the disease progresses more quickly than in others. As the disease progresses, the shaking, or tremor, which affects the majority of PD patients may begin to interfere with daily activities. Other symptoms may include depression and other emotional changes; difficulty in swallowing, chewing, and speaking; urinary problems or constipation; skin problems; and sleep disruptions.
The expression "Down's syndrome" as used herein refers to a chromosome abnormality, usually due to an extra copy of the 21st chromosome. This syndrome, usually but not always, results in mental retardation and other conditions. The term "mental retardation" refers to a below-average general intellectual function with associated deficits in adaptive behavior that occurs before age 18.
The term "mild-cognitive impairement" as used herein refers to a transitional stage of cognitive impairment between normal aging and early Alzheimer's disease. It refers particularly to a clinical state of individuals who are memory impaired but are otherwise functioning well and do not meet clinical criteria for dementia.
The term "obesity" as used herein refers to a body mass index (BMI) which is greater than 30 kg/m^. The term "dementia" as used herein refers to a group of symptoms involving progressive impairment of brain function. American Geriatrics Society refers to dementia as a condition of declining mental abilities, especially memory. The person will have problems doing things he or she used to be able to do, like keep the check book, drive a car safely, or plan a meal. He or she will often have problems finding the right words and may become confused when given too many things to do at once. The person with dementia may also change in personality, becoming aggressive, paranoid, or depressed.
The term "schizophrenia" as used herein refers to a group of psychotic disorders characterized by disturbances in thought, perception, attention, affect, behavior, and communication that last longer than 6 months. It is a disease that makes it difficult for a person to tell the difference between real and unreal experiences, to think logically, to have normal emotional responses to others, and to behave normally in social situations.
The term "anxiety" as used herein refers to a feeling of apprehension or fear. Anxiety is often accompanied by physical symptoms, including twitching or trembling, muscle tension, headaches, sweating, dry mouth, difficulty swallowing and/or abdominal pain.
The term "narcolepsy" as used herein refers to a sleep disorder associated with uncontrollable sleepiness and frequent daytime sleeping.
The term "depression" as used herein refers to a disturbance of mood and is characterized by a loss of interest or pleasure in normal everyday activities. People who are depressed may feel "down in the dumps" for weeks, months, or even years at a time. Some of the following symptoms may be symptoms of depression : persistent sad, anxious, or "empty" mood; feelings of hopelessness, pessimism; feelings of guilt, worthlessness, helplessness; loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex; decreased energy, fatigue, being "slowed down"; difficulty concentrating, remembering, making decisions; insomnia, early-morning awakening, or oversleeping; appetite and/or weight loss or overeating and weight gain; thoughts of death or suicide; suicide attempts; restlessness, irritability; persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain. The term "epilepsy" as used herein refers a brain disorder in which clusters of nerve cells, or neurons, in the brain sometimes signal abnormally. In epilepsy, the normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and behavior or sometimes convulsions, muscle spasms, and loss of consciousness. Epilepsy is a disorder with many possible causes. Anything that disturbs the normal pattern of neuron activity - from illness to brain damage to abnormal brain development - can lead to seizures.
Epilepsy may develop because of an abnormality in brain wiring, an imbalance of nerve signaling chemicals called neurotransmitters, or some combination of these factors. Having a seizure does not necessarily mean that a person has epilepsy. Only when a person has had two or more seizures is he or she considered to have epilepsy. The term "seizure" as used herein refers to a transient alteration of behaviour due to the disordered, synchronous, and rhythmic firing of populations of brain neurones.
The term "migraine" as used herein means a disorder characterised by recurrent attacks of headache that vary widely in intensity, frequency, and duration. The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. It is often accompanied by extreme sensitivity to light and sound, nausea, and vomiting. Some individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a lack of food or sleep, exposure to light, or hormonal irregularities (only in women). Anxiety, stress, or relaxation after stress can also be triggers. For many years, scientists believed that migraines were linked to the dilation and constriction of blood vessels in the head. Investigators now believe that migraine is caused by inherited abnormalities in genes that control the activities of certain cell populations in the brain. The International Headache Society (IHS, 1988) classifies migraine with aura (classical migraine) and migraine without aura (common migraine) as the major types of migraine.
Activity in any of the above-mentioned indications can of course be determined by carrying out suitable clinical trials in a manner known to a person skilled in the relevant art for the particular indication and/or in the design of clinical trials in general. For treating diseases, compounds of formula (I) or their pharmaceutically acceptable salts may be employed at an effective daily dosage and administered in the form of a pharmaceutical composition.
Therefore, another embodiment of the present invention concerns a pharmaceutical composition comprising an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable diluent or carrier.
To prepare a pharmaceutical composition according to the invention, one or more of the compounds of formula (I) or a pharmaceutically acceptable salt thereof is intimately admixed with a pharmaceutical diluent or carrier according to conventional pharmaceutical compounding techniques known to the skilled practitioner.
Suitable diluents and carriers may take a wide variety of forms depending on the desired route of administration, e.g., oral, rectal, parenteral or intranasal.
Pharmaceutical compositions comprising compounds according to the invention can, for example, be administered orally, parenterally, i.e., intravenously, intramuscularly or subcutaneously, intrathecally, by inhalation or intranasally.
Pharmaceutical compositions suitable for oral administration can be solids or liquids and can, for example, be in the form of tablets, pills, dragees, gelatin capsules, solutions, syrups, chewing-gums and the like. To this end the active ingredient may be mixed with an inert diluent or a non-toxic pharmaceutically acceptable carrier such as starch or lactose. Optionally, these pharmaceutical compositions can also contain a binder such as microcrystalline cellulose, gum tragacanth or gelatine, a disintegrant such as alginic acid, a lubricant such as magnesium stearate, a glidant such as colloidal silicon dioxide, a sweetener such as sucrose or saccharin, or colouring agents or a flavouring agent such as peppermint or methyl salicylate.
The invention also contemplates compositions which can release the active substance in a controlled manner. Pharmaceutical compositions which can be used for parenteral administration are in conventional form such as aqueous or oily solutions or suspensions generally contained in ampoules, disposable syringes, glass or plastics vials or infusion containers. hi addition to the active ingredient, these solutions or suspensions can optionally also contain a sterile diluent such as water for injection, a physiological saline solution, oils, polyethylene glycols, glycerine, propylene glycol or other synthetic solvents, antibacterial agents such as benzyl alcohol, antioxidants such as ascorbic acid or sodium bisulphite, chelating agents such as ethylene diamine-tetra-acetic acid, buffers such as acetates, citrates or phosphates and agents for adjusting the osmolality, such as sodium chloride or dextrose. These pharmaceutical forms are prepared using methods which are routinely used by pharmacists.
The amount of active ingredient in the pharmaceutical compositions can fall within a wide range of concentrations and depends on a variety of factors such as the patient's sex, age, weight and medical condition, as well as on the method of administration. Thus the quantity of compound of formula (I) in compositions for oral administration is at least 0.5
% by weight and can be up to 80 % by weight with respect to the total weight of the composition.
For the preferred oral compositions, the daily dosage is in the range 3 to 3000 milligrams (mg) of compounds of formula (I). hi compositions for parenteral administration, the quantity of compound of formula
(I) present is at least 0.5 % by weight and can be up to 33 % by weight with respect to the total weight of the composition. For the preferred parenteral compositions, the dosage unit is in the range 3 mg to 3000 mg of compounds of formula (I). The daily dose can fall within a wide range of dosage units of compound of formula (I) and is generally in the range 3 to 3000 mg. However, it should be understood that the specific doses can be adapted to particular cases depending on the individual requirements, at the physician's discretion. The following examples illustrate how the compounds covered by formula (I) may be synthesized. They are provided for illustrative purposes only and are not intended, nor should they be construed, as limiting the invention in any manner. Those skilled in the art will appreciate that routine variations and modifications of the following examples can be made without exceeding the spirit or scope of the invention. Unless specified otherwise in the examples, characterization of the compounds is performed according to the following methods:
NMR spectra are recorded on a BRUKER AC 250 Fourier Transform NMR Spectrometer fitted with an Aspect 3000 computer and a 5mm ^H/^c dual probehead or BRUKER DRX 400 FT NMR fitted with a SG Indigo2 computer and a 5 mm inverse geometry 1 H/ ^C/ ^N triple probehead. The compound is studied in dimethylsulfoxide-dg (DMSO- dβ) or chloroform-d (CDCI3) solution at a probe temperature of 313 K or 300 K and at a concentration of 20 mg/ml. The instrument is locked on the deuterium signal of dimethylsulfoxide-dg (DMSO- dg) or chloroform-d (CDCI3). Chemical shifts are given in ppm downfield from TMS taken as internal standard. HPLC analyses are performed using one of the following systems:
- an Agilent 1100 series HPLC system mounted with an INERTSIL ODS 3 C18, DP 5 μm, 250 X 4.6 mm column. The gradient runs from 100 % solvent A (acetonitrile, water, phosphoric acid (5/95/0.001, v/v/v)) to 100 % solvent B (acetonitrile, water, phosphoric acid (95/5/0.001, v/v/v)) in 6 min with a hold at 100 % B of 4 min. The flow rate is set at 2.5 ml/min. The chromatography is carried out at 35 °C.
- a HP 1090 series HPLC system mounted with a HPLC Waters Symetry C 18, 250 X 4.6 mm column. The gradient runs from 100 % solvent A (methanol, water, phosphoric acid (15/85/0.001M, v/v/M)) to 100 % solvent B (methanol, water, phosphoric acid (85/15/0.001 M, v/v/M)) in 10 min with a hold at 100 % B of 10 min. The flow rate is set at 1 ml/min. The chromatography is carried out at 40 °C.
Mass spectrometric measurements in LC/MS mode are performed as follows: HPLC conditions
Analyses are performed using a WATERS Alliance HPLC system mounted with an INERTSIL ODS 3, DP 5 μm, 250 X 4.6 mm column. The gradient runs from 100 % solvent A (acetonitrile, water, trifluoroacetic acid (10/90/0.1, v/v/v)) to 100 % solvent B (acetonitrile, water, trifluoroacetic acid (90/10/0.1, v/v/v)) in 7 min with a hold at 100 % B of 4 min. The flow rate is set at 2.5 ml/min and a split of 1/25 is used just before API source. MS conditions
Samples are dissolved in acetonitrile/water, 70/30, v/v at the concentration of about 250 μg/ml. API spectra (+ or -) are performed using a FINNIGAN LCQ ion trap mass spectrometer. APCI source operated at 450 °C and the capillary heater at 160 °C. ESI source operated at 3.5 kV and the capillary heater at 210 °C. Mass spectrometric measurements in DIP/EI mode are performed as follows: samples are vaporized by heating the probe from 50 0C to 250 0C in 5 min. EI (Electron Impact) spectra are recorded using a FINNIGAN TSQ 700 tandem quadrupole mass spectrometer. The source temperature is set at 150 0C.
Mass spectrometric measurements on a TSQ 700 tandem quadrupole mass spectrometer (Finnigan MAT) in GC/MS mode are performed with a gas chromatograph model 3400 (Varian) fitted with a split/splitless injector and a DB-5MS fused-silica column (15 m x 0.25 mm I.D., 1 μm) from J&W Scientific. Helium (purity 99.999 %) is used as carrier gas. The injector (CTC A200S autosampler) and the transfer line operate at 290 and 250 0C, respectively. Sample (1 μl) is injected in splitless mode and the oven temperature is programmed as follows: 50 °C for 5 min., increasing to 280 0C (23 °C/min) and holding for 10 min. The TSQ 700 spectrometer operates in electron impact (EI) or chemical ionization (CI/CH4) mode (mass range 33 - 800, scan time 1.00 sec). The source temperature is set at 150 °C.
Specific rotation is recorded on a Perkin-Elmer 341 polarimeter. The angle of rotation is recorded at 25 °C on 1 % solutions in methanol, at 589 run. For some molecules, the solvent is dichloromethane or dimethylsulfoxide, due to solubility problems.
Melting points are determined on a Bϋchi 535 or 545 Tottoli-type fusionometre, and are not corrected, or by the onset temperature on a Perkin Elmer DSC 7.
Preparative chromatographic separations are performed on silicagel 60 Merck, particle size 15-40 μm, reference 1.15111.9025, using Novasep axial compression columns (80 mm i.d.), flow rates between 70 and 150 ml/min. Amount of silicagel and solvent mixtures as described in individual procedures.
Preparative Chiral Chromatographic separations are performed on a DAICEL Chiralpak AD 20 μm, 100*500 mm column using an in-house build instrument with various mixtures of lower alcohols and C5 to C8 linear, branched or cyclic alkanes at ± 350 ml/min. Solvent mixtures as described in individual procedures.
Experiments requiring microwave irradiation were performed either on a CEM Discover apparatus (CEM corporation) or on a Biotage Initiator (Biotage AB) microwave oven using the flasks and stirrers sold by these companies.
EXAMPLES
Example 1. Synthesis of l-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)propyl]piperidine 30.
Figure imgf000085_0001
1.1 Synthesis of 4-(3-chloropropoxy)benzamide ax54.
A mixture of 4-hydroxybenzamide (5 g, 36.5 mmol, 1 eq), potassium carbonate (10.08 g, 72.9 mmol, 2 eq), 3-chloro-l-bromopropane (4.7 ml, 47.4 mmol, 1.3 eq) in butanone is stirred at reflux for 48 h. The solvent is then removed under vacuum and the residue is triturated in hexane and filtered. The solid is taken up in ethyl acetate and washed with a saturated solution of sodium hydrogencarbonate. The organic layer is dried over magnesium sulfate and concentrated to give 4-(3-chloropropoxy)benzamide ax54 (6.8 g) as a white solid.
Yield: 87 %.
LC-MS (MH+): 214/216.
The following compounds may be synthesized according to the same method:
Figure imgf000085_0002
1.2 Synthesis of 4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole ax57.
A mixture of 4-(3-chloropropoxy)benzamide ax54 (1.9 g, 8.9 mmol, 1 eq), 1,3- dichloro-propan-2-one (1.13 g, 8.9 mmol, 1 eq) in propionitrile (45 ml) is stirred at reflux for 48 h. The solvent is then removed under vacuum and filtered over silicagel with dichloromethane. The dichloromethane is evaporated under vacuum to give 4- (chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole ax57 (2.1 g) as a white solid.
Yield: 83 %.
LC-MS (MH+): 286/288/290.
The following compounds may be synthesized according to the same method:
Figure imgf000086_0001
1.3 Synthesis of l-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl}phenoxy)propyl]piperidine 30.
A mixture of 4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole ax57 (0.172 g, 0.6 mmol, 1 eq), sodium iodide (0.018 g, 0.12 mmol, 0.2 eq), potassium carbonate (0.373 g, 2.7 mmol, 4.5 eq) and 2-methylpyrrolidine in acetonitrile (5 ml) is stirred at room temperature for 72 h. Piperidine (0.05 g, 0.6 mmol, 1 eq) is then added and the mixture is stirred at 80 °C overnight. The volatiles are then removed under vacuum and the residue is purified by chromatography (dichloromethane/methanol/ammonia 96:3.6:0.4) to give 7-[3- (4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2-yl}phenoxy)propyl]piperidine 30 as a pale yellow oil.
Yield: 42 %.
LC-MS (MH+): 384.
Compounds 29, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 54, 56, 57, 58, 59, 60, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 84, 85, 86, 94, 118, 119, 120, 125, 129, 130, 138 and 146 of table I may be synthetized according to similar experimental conditions. Example 2. Synthesis of l-(3-{4-[4-methyl-5-(piperidin-l-ylmethyl)-l,3-oxazol-2- yl]phenoxy}propyl)piperidine 61.
Figure imgf000087_0001
2.1 Synthesis of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5- carboxylate ax60.
A solution of 4-(3-chloro-propoxy)-benzamide (0.5 g, 2.34 mmol, 1 eq) and methyl 2-chloro-3-oxobutanoate (0.7 ml, 5.62 mmol, 2.4 eq) in ethanol (5 ml) is heated at 110 °C in a sealed tube for 24 h. The mixture is concentrated, taken up in dichloromethane and washed with water. The organic phase is dried over magnesium sulfate and concentrated. The residue is purified by chromatography over silicagel (eluent: dichloromethane) to afford 0.7 g of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5-carboxylate ax60 as a pale yellow solid.
Yield : 96 %. LC-MS (MH+): 309/311.
2.2 Synthesis of {2-[4-(3-chJoropropoxy)phenyl]-4-methyl-l,3-oxazol-5- yljmethanol axόl.
A solution of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5- carboxylate ax60 (390 mg, 1.26 mmol, 1 eq) and methanol (165 μl, 4.08 mmol, 1.8 eq) in tetrahydrofuran (13 ml) is treated with lithium borohydride (49 mg, 2.27 mmol, 1.8 eq) and the mixture is stirred at 70 0C for 1 h. After cooling back to 0 °C, the mixture is treated dropwise with 1 N aqueous hydrochloric acid (1 ml). The mixture is then made basic (pH 10) with 2 N aqueous sodium hydroxide and extracted with ethyl acetate. The organic phase is then dried over magnesium sulfate and concentrated to give 330 mg of {2-[4-(3- chloropropoxy)phenyl]-4-methyl-l,3-oxazol-5-yl}methanol ax61 as a yellow solid. Yield : 93 %. LC-MS (MH+): 282/284. 2.3 Synthesis ofl-(3-{4-[4-methyl-5-(piperidin-l-ylmethyl)-l,3-oxazol-2- yl]phenoxy}propyl)piperidine 61.
A solution of {2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazol-5-yl}methanol ax61 (330 mg, 1.21 mmol, 1 eq) and triethylamine (187 μl, 1.33 mmol, 1.1 eq) in dichloromethane (25 ml) is cooled to 0 0C (ice bath) and treated dropwise with methanesulfonyl chloride (103 μl, 1.33 mmol, 1.1 eq). The mixture is stirred 1 h at 0 0C and poured into 20 ml of a saturated aqueous solution of ammonium chloride and extracted with dichloromethane. The organic phases are dried over magnesium sulfate and concentrated. The oily residue is taken up in acetonitrile (25 ml) and treated with sodium iodide (18 mg, 0.12 mmol, 0.1 eq) andpiperidine (360 μl, 3.64 mmol, 3 eq). The mixture is stirred at 22 0C for 1 h and then heated at 90 0C (oil bath) overnight. After cooling, the mixture is poured into 10 ml of 1 N aqueous hydrogen chloride and extracted with ether. The aqueous phase is then made basic (pH 10) by addition of 3 N aqueous sodium hydroxide, and extracted with ethyl acetate. The ethyl acetate solution is dried over magnesium sulfate and concentrated to yield 310 mg of an orange oil. This oil is purified by chromatography over silicagel (eluent: dichloromethane/methanol/ ammonia 98:1.8:0.2) to afford 60 mg of l-(3-{4-[4-methyl-5-(piperidin-l-ylmethyl)-l,3-oxazol-2» yl]phenoxy}propyl)piperidine 61 as a pale yellow oil.
Yield: 12 %.
LC-MS (MH+): 398.
Example 3. Synthesis of2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-4-(2- pyrrolidin-l-ylethyl)-l, 3-oxazole 55.
Figure imgf000088_0001
3.1 Synthesis of methyl {2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}acetate ax62.
Methyl 4-chloro-3-oxobutanoate (4.32 ml, 37.44 mmol, 2 eq) is added to a solution of 4-(3-chloropropoxy)benzamide (4 g, 18.72 mmol, 1 eq) in propionitrile (50 ml). The mixture is heated at reflux for 48 h. The mixture is then diluted with dichloromethane and filtered. The solvent is removed under vacuum and the residue is purified on silica gel (eluent: ethyl acetate) to give 2.8 g methyl {2-[4-(3-chloropropoxy)phenyl]~l,3-oxazol-4~ yl}acetate ax62 as a brown oil.
Yield : 50 %. LC-MS (MH+): 310/312.
3.2 Synthesis of {2-[4-(3-chloropropoxy)phenyl] -1 , 3-oxazol-4-yl}acetic acid ax63.
A solution of lithium hydroxide hydrate (0.76 g, 18.11 mmol, 2 eq) in water (10 ml) is added to a solution of methyl {2-[4-(3-chloropropoxy)phenyl]- 1 ,3-oxazol-4-yl} acetate ax62 (2.8 g, 9.06 mmol, 1 eq) in tetrahydrofuran (100 ml). The mixture is stirred at room temperature for 1 h. The mixture is then poured into water and extracted with diethyl ether (2 x 75 ml). The aqueous layer is acidified with 6 N aqueous hydrochloric acid and extracted with ethyl acetate. The organic layer is dried over magnesium sulfate and concentrated under vacuum to give 2.1 g of {2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4- yl} acetic acid ax63 as a brown solid. Yield : 81 %. LC-MS (MH+): 296/298.
3.3 Synthesis of 2-[4-(3-chloropropoxy)phenyl] -4-(2-oxo-2-pyrrolidin-l- ylethyl)-l,3-oxazole ax64.
To a solution of of {2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}acetic acid ax63 (0.5 g, 1.69 mmol, 1 eq) in dichloromethane (50 ml) is added 1-hydroxybenzotriazole (0.025 g, 0.19 mmol, 0.11 eq) and l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.357 g, 1.86 mmol, 1.1 eq). To that solution is added pyrrolidine (0.29 ml, 3.38 mmol, 2 eq) and the mixture is stirred at room temperature overnight. The mixture is poured into water and extracted with dichloromethane. The organic layer is dried over magnesium sulfate and the solvent is removed under vacuum to afford 0.51 g of 2-[4-(3- chloropropoxy)phenyl]-4-(2-oxo-2-pyrrolidin-l-ylethyl)-l,3-oxazole ax64 as a pale yellow oil.
Yield : 86 %.
LC-MS (MH+): 349/351.
The following compounds may be synthesized according to the same method:
Figure imgf000090_0001
3.4 Synthesis of 2- {4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-4-(2-oxo-2- pyrrolidin-l-ylethyl)-l,3-oxazole 52.
To a solution of 2-[4-(3-chloropropoxy)phenyl]-4-(2-oxo-2-pyrrolidin-l-ylethyl)- 1,3-oxazole ax64 (0.51 g, 1.46 mmol, 1 eq) in acetonitrile (10 ml) is added sodium iodide (0.022 g, 0.15 mmol, 0.1 eq) and 2-methylpyrrolidine (0.25 ml, 2.92 mmol, 2 eq). The mixture is stirred at reflux overnight. The mixture is poured into dichloromethane and washed with water. The organic layer is dried over magnesium sulfate and the solvent is removed under vacuum. The crude product is purified by chromatography over silica gel (eluent: dichloromethane/methanol/ammonia 95:4.5:0.5) to give 0.29 g of 2-{4-[3-(2- methylpyrrolidin- 1 -yl)propoxy]phenyl} -4-(2-oxo-2-pyrrolidin- 1 -ylethyl)- 1 , 3 -oxazole 52 as a yellow oil.
Yield : 50 %.
LC-MS (MH+): 398.
Compounds 80, 81, 128, 132, 133, 134 and 135 of table I may be synthetized according to similar experimental conditions. 3.5 Synthesis of2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-4-(2- pyrrolidin-l-ylethyl)-l, 3-oxazole 55.
To a solution of sodium borohydride (0.05 g, 1.21 mmol, 2.4 eq) in tetrahydrofuran (0.5 ml) is added a solution of 2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-4-(2~ oxo-2-pyrrolidin-l-ylethyl)-l, 3-oxazole 52 (0.2 g, 0.5 mmol, 1 eq) in tetrahydrofuran (2 ml). The mixture is cooled down to 0 °C (ice bath) and a solution of iodine (0.13 g, 0.5 mmol, 1 eq) in tetrahydrofuran (1 ml) is added dropwise. When the release of gas has stopped, the mixture is heated to reflux overnight. Methanol is added to the mixture at 0 °C until complete dissolution. The solvent is removed under vacuum to give a white solid. The solid is taken up into a 20 % methanolic solution of potassium hydroxide and the mixture is heated at 60 °C for 1O h. The mixture is poured onto water and extracted with dichloromethane. The organic layer is dried over magnesium sulfate and the solvent is removed in vacuum. The crude product is purified by chromatography over silica gel (eluent: gradient of dichloromethane/methanol/ammonia) to give 0.03 g of 2-{4-[3-(2- methylpyrrolidin- 1 -yl)propoxy]phenyl} -4-(2-pyrrolidin- 1 -ylethyl)- 1 ,3 -oxazole 55 as an orange oil.
Yield : 16 %.
LC-MS (MH+): 384.
Compound 82 of table I may be synthetized according to similar experimental conditions.
Example 4. Synthesis of2-methyl-l-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3- oxazol-2-yl}phenoxy)propyl]piperidine bis(trifluoroacetate) 47.
Figure imgf000091_0001
4.1 Synthesis of4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2-yl}phenol ax65.
4-{4-[(2-chloromethyl]-l,3-oxazol-2-yl}phenol (1.7 g, 8.1 mmol), prepared according to the method described in PCT patent application WO 03/097047, is reacted with 2-methylpyrrolidine (0.88 ml, 8.9 mmol) in the presence of potassium carbonate (2.24 g, 16.2 mmol) and sodium iodide (0.12 g, 0.81 mmol) in refluxing acetonitrile (50 ml). After 20 h, the solvent is evoporated, taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chromatography on silicagel (eluent: dichloromethane/methanol/ammonia 94:5.4:0.6) affords 1.3 g of compound ax65.
Yield: 62 %.
LC-MS (MH+): 259.
4.2 Synthesis of 2-[4-(3-chloropropoxy)phenyl] -4-[(2-methylpyrrolidin-l- yl)methyl] -1 ,3-oxazole ax66.
A mixture of l-bromo-3-chloropropane (0.7 mmol, 2 eq, 11.5 mg), potassium carbonate (0.7 mmol, 2 eq, 98 mg) and 4-{4-[(2-methylpyrrolidm-l-yl)methyl]-l,3-oxazol- 2-yl}phenol ax65 (0.35 mmol, 1 eq, 91.5 mg) in acetone (1.25 ml) is stirred at 56 °C overnight. The mixture is then filtered, washed with acetone (2 x 500 μl), and the solvent is removed under reduced pressure. The residue is dissolved in 3.5 ml of dichloromethane and washed twice with water (2 x 3.5 ml) and finally with brine (3.5 ml). The organic layer is dried over magnesium sulfate, filtered and the solvent is removed under reduced pressure. The crude product is used directly in the next step. LC-MS (MH+): 335/337.
The following compounds may be s nthesized according to the same method:
Figure imgf000092_0001
4.3 Synthesis of 2-methyl-l-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl] -1 ,3- oxazol-2-yl}phenoxy)propyl]piperidine bis(trifluoroacetate) 47.
A solution of 2-[4-(3-chloropropoxy)phenyl]-4-[(2-methylpyrrolidin-l-yl)methyl]- 1,3-oxazole ax66 (0.05 mniol, 1 eq, 17 mg) in 150 μL of acetonitrile is added to a solution of sodium iodide (0.1 mmol, 2 eq, 15 mg) and 2-methylpiperidine (0.1 mmol, 2 eq, 10 mg) in 270 μl of acetonitrile. The mixture is then stirred at 85 0C overnight, filtered, washed with acetonitrile, and concentrated under reduced pressure. The residue is purified by preparative liquid chromatography (gradient: acetonitrile/water/trifluroacetic acid 95:5:0.1 to 5:95:0.1) to provide 9 mg of 2-methyl-l-[3-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3- oxazol-2-yl}phenoxy)propyl]piperidine bis(trifluoroacetate) 47.
LC-MS (MH+): 398.
Compounds 46, 48, 49, 50 and 51 of table I may be synthetized according to the same method.
Example 5. Synthesis of4-(l-pyrrolidinylmethyl)-2-{4-[3-(l- pyrrolidinyl)propoxy]phenyl}-l,3-ihiazole 73.
Figure imgf000093_0001
5.1 Synthesis of 4-(3-chloropropoxy) benzenecarbothioamide ax71.
4-(3-Chloropropoxy)benzamide ax54 (1.0 g, 4.6 mmole, 1 eq) is dissolved in a 1:1 mixture of chloroform and toluene, 2,4-bis-(4-methoxyphenyl)-l,3-dithia-2,4- diphosphetane-2,4-disulfide (1.5 g, 3.7 mmole, 0.8 eq) is added. The reaction is stirred overnight at 85 °C. Water is then added and the phases are separated. The organic layer is dried over magnesium sulfate and concentrated under reduce pressure. The crude material is purified by chromatography on silicagel (eluent: dichloromethane/methanol/ammonia 98:1.8:0.2) to provide 0.91 g of 4-(3-chloropropoxy) benzenecarbothioamide ax71 as a white solid.
Yield: 85 %.
LC-MS (MH+): 230/232.
5.2. Synthesis of 4-(chloromethyl)~2-[4-(3-chloropropoxy)phenyl] -1 , 3-thiazole ax72.
4-(3-chloropropoxy)benzenecarbothioamide ax71 (0.9 g, 4 mmole, 1 eq) is dissolved in propionitrile (20 ml) and 1,3-dichloroacetone (0.6 g, 4.7 mmole, 1.17 eq) is added. The mixture is refluxed 1 h at 100 0C then concentrated to dryness. The crude material is taken up in dichlorόmethane, washed with water and dried over magnesium sulfate. The residue is triturated in diisopropylether and filtered off to give 1.1 g of 4- (chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l, 3-thiazole ax72 as a white solid.
Yield: 91 %. LC-MS (MH+): 302/304/306.
5.3. Synthesis of4-(l-pyrro1idinylmethyl)-2-{4-[3-(l-pyrrolidinyl)propoxy]phenyl}- 1, 3-thiazole 73.
A mixture of 4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l, 3-thiazole ax72 (250 mg, 0.83 mmole, 1 eq) and pyrrolidine (0.3 ml, 3.6 mmol, 4.4 eq) is dissolved in acetonitrile (10 ml). Potassium carbonate (0.5 g,3.6 mmole, 4.4 eq) and sodium iodide (25 mg, 0.17 mmole, 0.2 eq) are added. The solution is heated at 90 °C in a sealed tube for 48 h. After cooling, the solution is taken up in dichloromethane, washed with water and dried over magnesium sulfate. The crude material is purified by chromatography on silicagel (gradient: dichloromethane/methanol/ammonia 95:4.5:0.5 to 90:9: 1) to provide 0.31 g of 4- (l-pyrrolidinylmethyl)-2-{4-[3-(l-pyrrolidinyl)propoxy]phenyl}-l,3-thiazole 73 as a brown oil.
Yield: 13 %.
LC-MS (MH+): 372.
Compounds 72 and 74 of table I may be synthetized according to similar experimental conditions.
Compounds 75, 76, 77, 78 and 79 of table I may be synthetized from intermediate ax72 using similar experimental conditions than in example 1.3. Example 6. Synthesis of l-(3-{4-[5-methyl-4-(piperidin-l-ylmethyl)-l!3-oxazol-2- yl]phenoxy}propyl)piperidine 87.
Figure imgf000095_0001
6.1 Synthesis of 2-[4-(3-chloropropoxy)phenyl] -4, 5 -dimethyl- 1, 3-oxazole i30.
A suspension of 4-(3-chloropropoxy)benzamide ax54 (1.2 g, 5.62 mmol) and 3- bromobutan-2-one (1.02 g, 6.74 mmol) is heated in propionitrile (50 ml) at reflux for 10 days. The mixture is then concentrated and the resulting black mixture is filtered through a pad of silicagel, eluting first with dichloromethane (100 ml) and then with a 96:4 mixture of dichloromethane and dimethoxymethane to afford two fractions. The second fraction is concentrated, and the resulting yellow solid (0.67 g) is further purified by chromatography over silicagel (eluent: dichloromethane) to afford 330 mg of 2-[4-(3- chloropropoxy)phenyl]-4,5-dimethyl-oxazole i30 as a pale yellow solid.
Yield: 10 %.
LC-MS (MH+): 266/268.
6.2 Synthesis of 4-(bromomethyl)-2-[4-(3-chloropropoxy)phenyl] -5-methyl-l , 3- oxazole i31 and 4-(bromomethyl)-2-[4-(3-bromopropoxy)phenyl] -5-methyl-l , 3-oxazole i32. A solution of 2-[4-(3-chloropropoxy)phenyl]-4,5-dimethyl-oxazole i30 (0.33 g, 1.24 mmol) in acetonitrile (5 ml) is treated with N-bromosuccinimide (0.22 g, 1.24 mmol) and the mixture is stirred at 22 0C for 2 hours. The mixture is then poured into 20 ml of saturated sodium hydrogenocarbonate and extracted with dichloromethane (2 x 15 ml). The combined organic phases are dried over magnesium sulfate and concentrated to afford 390 mg of a pale yellow solid corresponding to a 2:1 mixture of 4-(bromomethyl)-2-[4-(3- chloropropoxy)phenyl]-5-methyl- 1 ,3-oxazole i31 and 4-(bromomethyl)-2-[4-(3- bromopropoxy)phenyl]-5-methyl-l, 3-oxazole i32 which is used directly in the next step. Yield: 91 %.
LC-MS (MH+): 344/346/348 (131) and 388/390/392 (i32).
6.3 Synthesis ofl-(3- {4-[5-methyl-4-(piperidin-l -ylmethylj-l, 3-oxazol-2- yl]phenoxy}propyl)piperidine 87.
A solution of the above mixture (330 mg) and piperidine (379 μl, 3.83 mmol) in acetonitrile (10 ml) is treated with sodium iodide (14 mg, 0.10 mmol) and stirred at 22 0C for 1 hour, then heated at 90 °C for 20 hours. The mixture is then poured into 10 ml of 0.1 N hydrochloric acid and extracted with ether (10 ml). The aqueous phase is then treated with 2 M sodium hydroxide to reach pH 10 and extracted with dichloromethane (3 x 5 ml). The combined dichloromethane extracts are dried over magnesium sulfate and concentrated to afford an orange oil (300 mg), which is purified by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 96/3.6/0.4) to afford l-(3-{4-[5-methyl-4- (piperidin-l-ylmethyl)-l,3-oxazol-2-yl]phenoxy}propyl)piperidine 87 (190 mg). Yield: 49 %.
LC-MS (MH+): 398.
Example 7. Synthesis of4-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol- 4-yl)carbonyl]rnorpholine 90.
Figure imgf000096_0001
7.1 Synthesis of ethyl 2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-4-carboxylate i33.
A mixture of 4-(3-chloropropoxy)benzamide ax54 (3.55 g, 16.6 mmol, 1 eq) and ethyl bromopyruvate (3.24 g, 16.6 mmol, 1 eq) in propionitrile (60 ml) is heated at reflux. After 24 h, the solvent is evaporated, and the residue is taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chromatography over silicagel (eluent: dichloromethane/ hexane 90:10) affords 2.12 g of ethyl 2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-4-carboxylate i33.
Yield: 41 %. LC-MS (MH+): 310/312.
7.2 Synthesis of 2-[4-(3-chloropropoxy)phenyl] -1 ,3-oxazole-4-carboxylic acid i34.
A 2 N aqueous solution of sodium hydroxide (10 ml, 20.3 mmol, 3 eq) is added dropwise to a solution of ethyl 2- [4-(3 -chloropropoxy)phenyl] -1,3 -oxazole-4-carboxylate i33 (2.1 g, 6.8 mmol, 1 eq) in ethanol (60 ml). The mixture is refluxed for 2h30 and the solvent is evaporated. The residue is taken up in water and acidified to pH 2 with a 2 N hydrochloric acid solution. The solid that precipitates is filtered off and washed with water to give 1.5 g of 2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-4-carboxylic acid i34. Yield: 79 %.
LC-MS (MH+): 282/284.
7.3 Synthesis o/4-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4- yl}carbonyl)morpholine i35. A solution of 2- [4-(3 -chloropropoxy)phenyl] -1,3 -oxazole-4-carboxylic acid i34
(0.5 g, 1.57 mmol, 1 eq), morpholine (0.15 g, 1.73 mmol, 1.1 eq) and triethylamine (0.44 ml, 3.14 mmol, 2 eq) in dichloromethane (20 ml) is cooled to 0 °C. N-(3- dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (0.33 g, 1.73 mmol, 1.1 eq) and 1-hydroxybenzotriazole (0.04 g, 0.31 mmol, 0.2 eq) are added to the solution and the mixture is stirred 24 h at room temperature. The mixture is then washed with water and a saturated solution of aqueous ammonium chloride. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum to give 0.54 g of 4-({2-[4-(3- chloropropoxy)phenyl]-l,3-oxazol-4-yl}carbonyl)morpholine i35. Yield: 98 %. LC-MS (MH+): 351/353. The following compounds may be synthesized according to the same method
Figure imgf000098_0001
7.4 Synthesis of 4-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3- oxazol-4-yl)carbonyl]morpholine 90.
4-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}carbonyl)moφholine i35 (0.26 g, 0.75 mmol, 1 eq) is reacted with 2-methylpyrrolidine (0.11 ml, 1.13 mmol, 1.5 eq) in the presence of potassium carbonate (0.2 g, 1.5 mmol, 2 eq) and a catalytic amount of sodium iodide in refluxing acetonitrile (15 ml) overnight. The solvent is then evaporated, and the residue taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 96:3.6:0.4) affords 0.11 g of 4-[(2-{4-[3-(2- methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4-yl)carbonyl]morpholine 90. Yield: 37 %.
LC-MS (MH+): 400. Compounds 91, 92, 93, 102, 103, 104, 107 and 131 of table (I) may be synthetized according to similar experimental conditions.
Example 8. Synthesis ofN-(cyclopropylmethyl)-4-methyl-2-{4-[3-(2-methyl-l-pyrrolidinyl) propoxy]phenyl}-N-propyl-l,3-oxazole-5-carboxamide 97 and N-(cyclopropylmethyl)-N- [(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-5-yl)methyl]-N- propylamine 112.
Figure imgf000099_0001
8.1 Synthesis of 2-[4-(3-chloropropoxy)phenyl] -4-methyl-l , 3-oxazole-5- carboxylic acidi43.
A suspension of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5- carboxylate ax60 (4.0 g, 12.9 mmol, 1 eq) in a 1:1 mixture of methanol and water (100 ml) is treated with a 1 M solution of sodium hydroxide (14 ml, 14 mmol, 1.1 eq). The mixture is stirred at 60 0C during 2 h, then the mixture is concentrated. The residue is taken up in water (20 ml) and a 1 M hydrochloric acid solution (14 ml, 14 mmol, 1.1 eq) is added. The resulting suspension is filtered and the filtrate is concentrated to give 3.4 g of 2-[4-(3- chloropropoxy)phenyl] -4-methyl- 1 ,3 -oxazole-5 -carboxylic acid i43.
Yield: 88 %.
LC-MS (MH+): 296/298.
8.2 Synthesis of 2-[4~(3-chloropropoxy)phenyl]-N-(cyclopropylmethyl)-4- methyl-N-propyl-1 , 3-oxazole-5-carboxamide i44.
A mixture of 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5-carboxylic acidi43 (3.18 g, 10.75 mmol, 1 eq) and triethylamine (1.5 ml, 10.75 mmol, 1 eq) in chloroform (70 ml) is cooled to 0 0C. Thionyl chloride (2.3 ml, 32 mmol, 3 eq) is then added dropwise. The mixture is refiuxed for 2h30 and the solvent is evaporated. The residue is taken up in cold dichloromethane (20 ml, 0 0C) and treated with triethylamine (0.6 ml, 4.3 mmol, 2 eq) and N-(cyclopropylmethyl)propan~l -amine (0.29 g, 2.58 mmol, 1.2 eq). The mixture is stirred at room temperature overnight and then washed two times with a saturated solution of aqueous ammonium chloride. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum to give 0.82 g of 2-[4-(3- chloropropoxy)phenyl]-N-(cyclopropylmethyl)-4-methyl-N-propyl-l,3-oxazole-5- carboxamide i44.
Yield: 97 %.
LC-MS (MH+): 391/393.
The following compounds may be synthesized according to the same method:
Figure imgf000100_0001
8.3 Synthesis of N-(cyclopropylmethyl)-4-methyl-2-{4-[3-(2-methylpyrrolidin-l- yl)propoxy] phenyl }-N-propyl-l ,3-oxazole-5-carboxamide 97.
2-methylpyrrolidine (0.24 ml, 2.46 mmol, 1.2 eq) is added to a solution of 2-[4-(3- chloropropoxy)phenyl]-N-(cyclopropylmethyl)-4-methyl-N-propyl-l,3-oxazole-5- carboxamide i44 (0.8 g, 2 mmol, 1 eq), potassium carbonate (0.55 g, 4 mmol, 2 eq) and a catalytic quantity of sodium iodide in refluxing acetonitrile (25 ml). After stirring for 20 h at reflux, the solvent is evoporated and the residue is taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chromatography over silicagel (eluent: dichloromethane/ methanol/ammonia 96:3.6:0.4) affords 0.31 g of N-(cyclopropyhnethyl)-4-methyl-2-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl}-N-propyl-l,3-oxazole-5-carboxamide 97. Yield: 35 %. LC-MS (MH+): 440.
Compounds 96, 98, 105, 106, 108, 109, and 110 of table (I) maybe synthetized according to similar experimental conditions.
8.4 Synthesis ofN-(cyclopropylmethyl)-N-[(4-methyl-2- {4-[3-(2-methyl pyrrolidin-l-yl)propoxy] phenyl }-l ,3-oxazol-5-yl)methyl) ' -N-propylamine 112.
A solution of N-(cyclopropylmethyl)-4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 - yl)propoxy]phenyl}-N-propyl-l,3-oxazole-5-carboxamide 97 (0.25 g, 0.57 mmol, 1 eq) in tetrahydrofuran (15 ml) is treated with borane-tetrahydrofuran complex 1 M in tetrahydrofuran (2.2 ml, 2.2 mmol, 4 eq) and refluxed overnight. The solvent is then removed under reduced pressure and the residue is taken up in ethyl acetate and washed with a saturated solution of aqueous ammonium chloride. The organic layer is dried over magnesium sulfate, filtered and concentrated. The residue is then dissolved in tetrahydrofuran and a 2 N sodium hydroxyde solution is added to reach pH 10. The mixture is refluxed for 40 h and a saturated solution of aqueous ammonium chloride is added and the solution extracted two times with ethyl acetate. The organic layers are dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 96/3.6/0.4) gives 0.115 g of N-(cyclopropylmethyl)-N-[(4-methyl-2-{4-[3-(2-methyl pyrrolidin-1- yl)propoxy]phenyl}-l,3-oxazol-5-yl)methyl]-N-propylamine ll2. Yield: 48 %. LC-MS (MH+): 426.
Compounds 111, 113, 116 and 143 of table I may be synthetized according to similar experimental conditions.
Example 9. Synthesis of l-[2-(2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy] phenyl}-l,3-oxazol- 4-yl) ethyl] piperidine 121.
Figure imgf000102_0001
9.1 Synthesis of methyl [2-(4-hydroxyphenyl)-l , 3-oxazol-4-yl] acetate i50.
A solution of 4-hydroxybenzamide (10 g, 7.3 mmol, 1 eq) and methyl 4-chloro-3- oxobutanoate (15 g, 11 mmol, 5 eq) in propionitrile (300 ml) is stirred at reflux (98 °C) during 3 days. After concentration under reduced pressure, the residue is purified over silicagel (eluent: dichloromethane/methanol/ammonia 90:9:1) to yield 7 g of methyl [2-(4- hydroxyphenyl)-l,3-oxazol-4-yl]acetate i50.
Yield: 41 %.
LC-MS (MH+): 234.
9.2 Synthesis of methyl {2-[4-(2-chloroethoxy)phenyl] -1 ,3-oxazol-4-yl}acetate iSL
A mixture of methyl [2-(4-hydroxyphenyl)-l,3-oxazol-4-yl]acetate i50 (1 g, 4.29 mmol, 1 eq), potassium carbonate (2.37 g, 17.16 mmol, 4 eq) and l-bromo-2-chloroethane (1.54 g, 10.7 mmol, 2.5 eq) in acetone (50 ml) is stirred at reflux for 140 h. Potassium carbonate is then filtered off and the solvent is evaporated. The residue is taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum to give 1.1 g of methyl {2-[4-(2-chloroethoxy)phenyl]-l,3-oxazol-4-yl}acetate i51.
Yield: 87 %.
LC-MS (MH+): 296/298. 9.3 Synthesis of methyl (2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3- oxazol-4-yl) acetate i52.
Methyl {2-[4-(2-chloroethoxy)phenyl]-l,3-oxazol-4-yl} acetate i51 (0.55 g, 1.86 mmol, 1 eq) is reacted with 2-niethylpyrrolidine (0.28 ml, 2.79 mmol, 1.5 eq) in the presence of potassium carbonate (0.77 g, 5.58 mmol, 3 eq) and a catalytic quantity of sodium iodide in refluxing acetonitrile (20 ml). After 45 h, the solvent is evaporated, the residue is then taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 97:2.7:0.3) affords 0.3 g of methyl (2-{4-[2-(2- methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3-oxazol-4-yl)acetate i52.
Yield: 47 %.
LC-MS (MH+): 345.
9.4 Synthesis of(2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3-oxazol~4- yl)acetic acid i53.
A 2 N aqueous sodium hydroxide solution (2.6 ml, 5.23 mmol, 6 eq) is added to a solution of methyl (2- {4-[2-(2-methylpyrrolidin- 1 -yl)ethoxy]phenyl} - 1 ,3-oxazol-4- yl)acetate i52 (0.3 g, 0.87 mmol, 1 eq) in ethanol (15 ml). The mixture is stirred at reflux for 3 h and the solvent is then evoporated. The residue is taken up in water, acidified with 2 N hydrochloric acid and the solvent is evoporated under reduced pressure to give 0.8 g of (2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3-oxazol-4-yl)acetic acid i53 together with remaining sodium chloride. The compound is used in the next step without any other treatment. LC-MS (MH+): 331.
9.5 Synthesis of l-[(2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l ,3-oxazol- 4-yl) acetyl] piperidine i54.
A solution of (2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3-oxazol-4- yl)acetic acid i53 (0.29 g, 0.87 mmol, 1 eq), piperidine (0.18 ml, 1.75 mmol, 2 eq) and triethylamine (0.36 ml, 3.6 mmol, 3 eq) in dichloromethane (20 ml) is cooled to 0 0C. N-(3- dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (0.42 g, 2.17 mmol, 2.5 eq) and 1-hydroxybenzotriazole (0.12 g, 0.87 mmol, 1 eq) are then added. The mixture is stirred 24 h at room temperature, and washed two times with a saturated solution of aqueous ammonium chloride. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chromotagraphy over silicagel (eluent: dichloromethane/methanol/ammonia 97/2.7/03) affords 0.15 g of l-[(2-{4-[2-(2- methylpyrrolidin- 1 -yl)ethoxy]phenyl} - 1 ,3-oxazol-4-yl)acetyl]piperidine i54. Yield: 44 %.
LC-MS (MH+): 398.
9.6 Synthesis ofl-[2-(2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3- oxazol-4-yl)ethyl]piperidine l21. A solution of l-[(2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3-oxazol-4- yl)acetyl]piperidine i54 (0.13 g, 0.33 mmol, 1 eq) in tetrahydrofuran (5 ml) is treated with borane-tetrahydrofuran complex (1.0 M in tetrahydrofuran, 1.3 ml, 1.3 mmol, 4 eq) and the resulting mixture is refluxed overnight. A 2 N sodium hydroxyde solution is added to reach pH 10 and the mixture is refluxed for 6 h. A saturated solution of aqueous ammonium chloride is added and the solution is extracted two times with ethyl acetate. The organic layers are dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 96/3.6/0.4) gives 0.115 g of l-[2-(2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]ρhenyl}-l,3- oxazol-4-yl)ethyl]piperidine 121. Yield: 23 %.
LC-MS (MH+): 384.
Example 10. Synthesis ofl-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol- 4-yl)methyl]piperidin-2-one 122.
Figure imgf000104_0001
10.1 Synthesis of l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl) piperidin-2-one i55.
A suspension of delta- valerolactani (0.14 g, 1.4 mmol, 1 eq) and sodium hydride (60 % dispersion in mineral oil, 0.056 g, 1.4 mmol, 1 eq) in N,N-dimethylformamide (10 ml) is cooled to 0 0C and treated with 4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]- 1,3-oxazole ax57 (0.4 g, 1.4 mmol, 1 eq). The mixture is then stirred at room temperature. After 20 h, the solvent is evaporated, the residue is taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum to give 0.58 g of 1- ({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)piperidin-2-one i55 immediately engaged in the next step without any further purification.
LC-MS (MH+): 349/351.
The following compounds may be synthesized according to the same method:
Figure imgf000105_0001
10.2 Synthesis of l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3- oxazol-4-yl)methyl] piperidin-2-one 122. l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)piperidin-2-one i55 (0.564 g, 1.62 mmol, 1 eq) is reacted with 2-methylpyrrolidine (0.19 ml, 1.94 mmol, 1.2 eq) in the presence of potassium carbonate (0.45 g, 3.24 mmol, 2 eq) and a catalytic quantity of sodium iodide in refluxing acetonitrile (20 ml). After 45 h, the solvent is evaporated. The residue is then taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 95:4.5:0.5) affords 0.27 g of l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl] piperidin-2-one 122.
Yield: 41 %.
LC-MS (MH+): 398.
Compounds 53, 123 and 137 of table I may be synthetized according to similar experimental conditions.
Example 11. Synthesis ofl-[(2-{3-chloro-4-[3-(2-methyl-l-pyrrolidinyl)propoxy]phenyl}- l,3-oxazol-4-yl)methyl]piperidine 124.
Figure imgf000106_0001
11.1 Synthesis of (2-chloro-l, 3-oxazol-4-yl)methyl methanesulfonate i59.
A solution of (2-chloro-l, 3 -oxazol-4-yl)methanol (5 g, 37.44 mmol, 1 eq, prepared according to the method described in Tetrahedron Lett. (2004), 45, 3797-3802) in dichloromethane (250 ml) is reacted with methanesulfonyl chloride (3.19 ml, 41.19 mmol, 1.1 eq) in the presence of triethylamine (5.79 ml, 41.19 mmol, 1.1 eq) at 0 0C. After lh30, the mixture is poured into a saturated solution of ammonium chloride and extracted twice with dichloromethane. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum to afford 7.9 g of (2-chloro-l ,3 -oxazol-4-yl)methyl methanesulfonate i59. This product is used in the next step without further purification or analysis. 11.2 Synthesis of l-[(2-chloro-l ,3-oxazol-4-yl)methyl]piperidine i60.
A solution of (2-chloro-l,3-oxazol-4-yl)methyl methanesulfonate i59 (7.9 g, 37.44 mmol, 1 eq), piperidine (7.41 ml, 74.89 mmol, 2 eq) and sodium iodide (0.56 g, 3.74 mmol, 0.1 eq) in acetonitrile (250 ml) is stirred at room temperature overnight. The mixture is then poured into a 0.1 N hydrochloric acid solution and extracted with diethyl ether. The organic layer is dried over magnesium sulfate, filtered and the solvent is removed under reduced pressure. Purification by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 98:1.8:0.2) affords 3 g of l-[(2-chloro-l,3-oxazol-4- yl)methyl]piperidine i60.
Yield: 40 %.
LC-MS (MH+): 201/203.
11.3 Synthesis of l-({2-[4-(benzyloxy)-3-chlorophenyl]-l,3-oxazol-4- yl}methyl)piperidine i61.
A solution of l-[(2-chloro-l,3-oxazol-4-yl)methyl]piperidine i60 (0.8 g, 3.99 mmol, 1 eq) in toluene (60 ml) is treated with (3-chloro-4-benzyloxyphenyl)boronic acid (1.05 g, 3.99 mmol, 1 eq) and a solution of potassium carbonate (1.1 g, 7.97 mmol, 2 eq), in water (5 ml). The mixture is degassed under argon and tetrakis(triphenylphosphine)palladium (0) (0.18 g, 0.16 mmol, 0.04 eq) is added. The mixture is then stirred at 70 °C in a sealed tube. After 24 h, the mixture is poured onto dichloromethane and washed with a 2 M sodium hydroxide solution. The organic layer is dried over magnesium sulfate, filtered and the solvent is removed under reduced pressure. The residue is purified by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 97.5:2.5:0.25 to 92.5:7.5:0.75) to provide 500 mg of l-({2-[4-(benzyloxy)-3-chlorophenyl]-l,3-oxazol-4- yl}methyl)piperidine i61.
Yield: 33 %.
LC-MS (MH+): 383/385.
The following compounds may be synthesized according to the same method:
Figure imgf000107_0001
i65 2-methoxy-4-[4-(piperidin- 1 -ylmethyl)- 1 ,3-oxazol-2- LC-MS (MH+): 289 yljphenol
11.4 Synthesis of 2-chloro-4-[4-(piperidin-l-ylmethyl)-l , 3 -oxazol-2-yl] phenol i66 and 2-fluoro-4-(4-piperidin-l-ylmethyl-oxazol-2-yl)-phenol i68.
To a solution of l-({2-[4-(benzyloxy)-3-chlorophenyl]-l,3-oxazol-4- yl}methyl)piperidine i61 (0.3 g, 0.78 nimol, 1 eq) in dodecanethiol (5 ml) is added dropwise boron trifluoride diethyl etherate (1.59 ml, 12.54 mmol, 48 eq). The mixture is stirred at room temperature for 60 h. Diethyl ether is poured onto the mixture and the solid that precipitates is filtered off and recrystallized from diethyl ether to give 150 mg of 2- chloro-4- [4-(piperidin- 1 -ylmethyl)- 1 ,3 -oxazol-2-yl]phenol i66. Yield: 66 %
LC-MS (MH+): 293/295.
2-fluoro-4-(4-piperidin-l-ylmethyl-oxazol-2-yl)-phenol i68 is synthesized according to the following method: a solution of l-({2-[4-(benzyloxy)-3-fluorophenyl]-l,3-oxazol-4- yl}methyl)piperidine i63 (0.34 g, 0.94 mmol, 1 eq) in ethanol is placed under hydrogen atmosphere (20 psi) at 30 °C for 6 hours. The mixture is filtered over cellite and concentrated under vacuo to give 0.22 g of 2-fluoro-4-(4-piperidin-l-ylmethyl-oxazol-2- yl)-phenol i68 as a brown solid. This crude product is used in the next step without any purification. Yield: 65 %.
1H NMR (DMSO) δ: 1.49 (m, 5 H), 2.38 (s, 4 H), 3.36 (s, 2 H), 7.07 (m, 1 H), 7.62 (s, 2 H), 7.95 (s, 1 H).
11.5 Synthesis of l-({2-[3-chloro-4-(3-chloropropoxy)phenyl] -1 ,3-oxazol-4- yl}methyl)piperidine i71.
A suspension of 2-chloro-4-[4-(piperidin-l-ylmethyl)-l,3-oxazol-2-yl]phenol i66 (0.13 g, 0.44 mmol, 1 eq), l-bromo-3-chloropropane (57 μl, 0.58 mmol, 1.3 eq) and potassium carbonate (0.12g, 0.89 mmol, 2 eq) is stirred at 50 0C overnight. The carbonate is then filtered off and the resulting solution is concentrated under reduced pressure to give 0.12 g of crude l-({2-[3-chloro-4-(3-chloropropoxy)phenyl]-l,3-oxazol-4- yl}methyl)piperidine ill as an oil, which is directly used in the next step.
Yield: 74 %. 1H NMR (CDCl3) δ: 1.45 (d, 5.02 Hz, 3 H), 1.61 (m, 7 H), 2.32 (m, 3 H), 2.48 (s Hz, 6 H), 3.48 (s Hz, 3 H), 3.81 (t, 6.15 Hz, 3 H), 4.24 (t, 5.78 Hz, 3 H), 6.99 (d, 8.79 Hz, 1 H), 7.54 (s Hz, 1 H), 7.90 (dd, 8.79, 1.88 Hz, 1 H), 8.08 (d, 1.76 Hz, 1 H).
The following compounds may be synthesized according to the same method :
Figure imgf000109_0001
11.6 Synthesis ofl-[(2-{3-chloro-4-[3-(2-methylpyrrolidin-l-yl)propoxy] phenyl}- 1, 3-oxazol-4-yl)methyl]piperidine 124.
A solution of l-({2-[3-chloro-4-(3-chloropropoxy)phenyl]-l,3-oxazol-4- yl}methyl)piperidine i71 (0.12 g, 0.32 mmol, 1 eq) and 2-methylpyrrolidine (63 μl, 0.65 mmol, 2 eq) in acetonitrile (10 ml) is treated with sodium iodide (5 mg, 0.03 mmol, 0.1 eq) and stirred at room temperature overnight. The mixture is then washed with water, dried over magnesium sulfate, and concentrated to give the crude product. Purification by chromatography over silicagel (eluent: dichloromethane/ methanol/ammonia 90: 10:0.1) gives 75 mg of l-[(2-{3-chloro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol- 4-yl)methyl]piperidine 124 as an orange oil.
Yield: 56 %.
LC-MS (MH+): 418/420.
Compounds 89, 95 and 114 of table I may be seynthetized according to similar experimental conditions. Example 12. Synthesis ofl-[(2-{2-fluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}- l,3-oxazol-4-yl)methyl]piperidine dimethanesulfonate 145.
Figure imgf000110_0001
12.1 Synthesis of 3-chloropropyl 4-(3-chloropropoxy)-2-fluorobenzoate i76.
2-fluoro-4-hydroxybenzoic acid (Ig, 6.41 mmol, 1 eq) is reacted with bromochloropropane (0.82 ml, 8.33 mmol, 1.3 eq) in the presence of potassium carbonate (1.77 g, 12.81 mmol, 2 eq) in methyl ethyl ketone (18 ml) at 80 °C overnight, filtered, washed with acetone and concentrated under vacuum to afford 2 g of 3-chloropropyl 4-(3- chloropropoxy)-2-fluorobenzoate i76.
Yield: 100 %.
LC-MS (MH+): 309/311/313.
The following compounds may be synthesized according to the same method :
Figure imgf000110_0002
12.2 Synthesis of4-(3-chloropropoxy)-2-fluorobenzoic acid i78.
A mixture of 3-chloropropyl 4-(3-chloropropoxy)-2-fiuorobenzoate i76 (2 g, 6.47 mmol, 1 eq) and 1 M sodium hydroxide (6.47 ml, 6.47 mmol, 1 eq) in methanol (25 ml) is stirred at room temperature overnight. The mixture is concentrated under vacuum, taken up in water and extracted with diethyl ether. The aqueous phase is acidified with a 1 N hydrochloric acid solution to reach pH 2, and the resulting suspension is filtered and the solid dried to give 0.68 g of 4-(3-chloropropoxy)-2-fluorobenzoic acid i78. Yield: 45 %.
LC-MS (MH+): 233/235.
The following compounds may be s nthesized according to the same method
Figure imgf000111_0001
12.3 Synthesis of4-(3-chloropropoxy)-2-fluorobenzoyl chloride 180. 4-(3-chloropropoxy)-2-fluorobenzoic acid i78 (0.68 g, 2.92 mmol, 1 eq) is refluxed in thionyl chloride (4.27 ml, 57.46 mmol, 20 eq) for 3 hours. The mixture is then concentrated under reduced pressure to give 0.73 g of crude 4-(3-chloropropoxy)-2- fluorobenzoyl chloride i80, which is used in the next step without purification.
4-(3-chloropropoxy)-2-methylbenzoyl chloride i81 and 4-(3-chloropropoxy)-3,5- difluorobenzoyl chloride ill3 may be synthesized according to the same method.
12.4 Synthesis of4-(3-chloropropoxy)-2-fluorobenzamide i82. 4-(3-chloropropoxy)-2-fluorobenzoyl chloride i80 (0.73 g, 2.91 mmol, 1 eq) is treated with aqueous ammonia (35 ml) and the resulting mixture is vigorously stirred at room temperature overnight. The mixture is then filtered to give 0.41 g of 4-(3- chloropropoxy)-2-fluorobenzamide Ϊ82 as a white solid. Yield: 61 %. LC-MS (MH+): 232/234.
The following compounds may be synthesized according to the same method
Figure imgf000111_0002
12.5 Synthesis of 4-(chloromethyl)-2-[4-(3-chloropropoxy)-2-fluorophenyl] -1 , 3- oxazole i84.
A mixture of 4-(3-chloropropoxy)-2-fluorobenzamide i82 (0.41 g, 1.75 mmol, 1 eq) and 1,3-dichloroacetone (0.49 g, 3.85 mmol, 2.2 eq) in propionitrile (9 ml) is stirred at 100 °C for 60 h. The mixture is then concentrated under vacuum, taken up in dichloromethane, and washed with water. The organic phase is dried over magnesium sulfate and concentrated under reduced pressure. The residue is purified by chromatography over silicagel (eluent: dichloromethane) to afford 0.23 g of 4-(chloromethyl)-2-[4-(3- chloropropoxy)-2 -fluorophenyl]- 1 ,3-oxazole i84.
Yield: 44 %.
LC-MS (MH+): 304/306/308.
The following compounds may be synthesized according to the same method
Figure imgf000112_0001
12.6 Synthesis ofl-({2-[4-(3-chloropropoxy)-2-fluorophenyl]-l,3-oxazol-4- yl}methyl)piperidine i86.
A solution of 4-(chloromethyl)-2-[4-(3-chloropropoxy)-2-fluorophenyl]-l,3-oxazole i84 (0.23 g, 0.75 mmol, 1 eq) in acetonitrile (10 ml) is treated with piperidine (0.14 ml, 1.5 mmol, 2 eq). The mixture is stirred at room temperature for 24 h and concentrated under vacuum. The residue is taken up in dichloromethane and washed with water. The organic layer is dried over magnesium sulfate and concentrated under reduced pressure to give 0.20 g of l-({2-[4-(3-chloropropoxy)-2-fluorophenyl]-l,3-oxazol-4-yl}methyl)piperidine i86.
Yield: 74 %.
LC-MS (MH+): 353/355.
The following compounds may be synthesized according to the same method :
Figure imgf000112_0002
12.7 Synthesis ofl-[(2-{2-fluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}- l,3-oxazol-4-yl)methyl] piperidine dimethanesulfonate 145.
A solution of l-({2-[4-(3-chloropropoxy)-2-fluorophenyl]-l,3-oxazol-4- yl}methyl)piperidine i86 (0.195 g, 0.55 mmol, 1 eq) and 2-methylpyrrolidine (0.107 ml, 1.11 mmol, 2 eq) in acetonitrile (25 ml) is treated with sodium iodide (8 mg, 0.06 mmol, 0.1 eq) and stirred at 90 0C overnight. The mixture is then poured into dichloromethane, and washed with water. The organic layer is dried over magnesium sulfate and concentrated. The residue is purified by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 90:10:0.1) to give 0.10 g of an oil. This oil is taken up in diethyl ether and an excess of methanesulfonic acid (I M solution in diethyl ether) is added. The resulting suspension is filtered and the solid is washed several times with diethyl ether to remove the excess of methanesulfonic acid. The solid is dried to give 0.10 g of 1 -[(2- {2-fluoro-4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl}- 1 ,3-oxazol-4-yl)methyl] piperidine dimethanesulfonate 145.
Yield: 30 %. LC-MS (MH+): 402.
Compounds 148 and 155 of table I may be synthetized according to similar experimental conditions.
Example 13. Synthesis of 2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazole 83.
Figure imgf000113_0001
13.1 Synthesis of 2-[4-(3-chloropropoxy)phenyl]-l ,3-thiazole i88.
A solution of 4-(3-chloropropoxy)benzenecarbothioamide ax71 (0.3 g, 1 eq, 1.31 mmol) in ethyl alcohol (5 ml) is treated with 1,3-dichloro-l-ethoxy-propane (0.4 ml, 2.7 eq, 3.6 mmol) and the mixture is stirred at 110 °C during 4 h. The mixture is then poured into dichloromethane (10 ml) and is washed with water. The organic phase is dried over magnesium sulfate and concentrated. Purification by chromatography over silicagel (eluent: dichloromethane) affords 120 mg of 2-[4-(3-chloropropoxy)phenyl]-l,3-thiazole i88. Yield: 36 %.
LC-MS (MH+): 254/256.
13.2 Synthesis of2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazole 83. A solution of 2-[4-(3-chloropropoxy)phenyl]-l,3-thiazole i88 (120 mg, 1 eq, 0.47 mmol) in acetonitrile (1 ml) is added to a solution of sodium iodide (10 mg, 0.1 eq, 0.07 mmol) and 2-methylpyrrolidine (0.1 ml, 2 eq, 0.9 mmol) in acetonitrile (1 ml). The mixture is stirred at 850C overnight, filtered, washed with acetonitrile, and concentrated under reduced pressure. Purification of the residue by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 96/4/0.4) affords 40 mg of 2-{4-[3-(2- methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazole 83.
Yield: 27 %.
LC-MS (MH+): 303.
Example 14. Synthesis of l-[(5-bromo-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}- 1, 3-oxazol-4-yl)methyl]piperidine 117.
Figure imgf000114_0001
14.1 Synthesis of 5-bromo-2-[4-(3-chloropropoxy)-phenyl] -4-chloromethyl- oxazole i89.
A solution of 4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole ax57 (0.5 g, 1.75 mmol, 1 eq) and N-bromosuccinimide (0.31 g, 1.75 mmol, 1 eq) in acetonitrile (16 ml) is stirred at 22 °C for 30 minutes. A heavy white precipitate forms during the reaction. The suspension is then filtered, the solid is washed with the minimum amount acetonitrile, collected and dried under vacuum at 400C to yield 290 mg of the title compound. The acetonitrile solution is concentrated to half its original volume to yield an additional 110 mg of 5-bromo-2-[4-(3-chloropropoxy)-phenyl]-4-chloromethyl-oxazole i89.
Yield: 63 %.
LC-MS (MH+): 364. 14.2 Synthesis of l-[(5-bromo-2-[4-(3-chloropropoxy)phenyl] -1 , 3-oxazol-4- yl)methyl]piperidine i90.
A solution of 5-bromo-2-[4-(3-chloropropoxy)-phenyl]-4-chloromethyl-oxazole i89 (0.41 g, 1.12 mmol, 1 eq) and piperidine (222 μl, 2.25 mmol, 2 eq) in dichloromethane (3 ml) and acetonitrile (20 ml) is stirred at 22° C for 6 h. The mixture is then poured into 20 ml of 0.1 N hydrochloric acid and extracted with dichloromethane (10 ml). The aqueous phase is then treated with 2 M sodium hydroxide to reach pH 10 and is extracted again with dichloromethane (3 x 10 ml). The three last extracts are combined, dried over magnesium sulfate and concentrated to yield 450 mg of a colourless oil, which is purified by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 97:2.7:0.3) to afford 390 mg of l-[(5-bromo-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4- yl)methyl]piperidine i90. Yield: 84 %.
LC-MS (MH+): 413/415/417.
14.3 Synthesis of l-[(5-bromo-2- {4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}- 1, 3-oxazol-4-yl)methyl] piperidine 117.
A solution of l-[(5-bromo-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4- yl)methyl]piperidine i90 (0.39 g, 0.94 mmol, 1 eq) and 2-methylpyrrolidine (192 μl, 1.89 mmol, 2 eq) in acetonitrile (6 ml) is treated with sodium iodide (14 mg, 0.09 mmol, 0.1 eq) and stirred for 24 h at 90 0C.2-Methylpyrrolidine (100 μl, 1 mmol) is then added and the mixture is stirred for a further 24 h at 90 0C. The mixture is then poured into 0.1 N hydrochloric acid (10 ml) and extracted with diethyl ether (10 ml). The aqueous phase is then treated with 1 N sodium hydroxide to reach pH 10 and extracted with dichloromethane (3 x 10 ml). The combined dichloromethane extracts are then dried over magnesium sulfate and concentrated to yield 370 mg of an orange oil which is purified by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 96:3.6:0.4) to yield 86 mg of 1- [(5-bromo-2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 , 3 -oxazol-4- yl)methyl]piperidine 117. Yield: 20 %.
LC-MS (MH+): 462/464. Example 15. Synthesis of methyl 2-{3-bromo-4-[3-(2-methyl-l-pyrrolidinyl) propoxy] phenyl }-4-methyl-l, 3-thiazole-5-carboxylate 126.
Figure imgf000116_0001
15.1 Synthesis of methyl 2-[3-bromo-4-(3-chloropropoxy)phenyl] -4-methyl-l , 3- thiazole-5-cai'boxylate i91.
A solution of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5- carboxylate ax60 (2 g, 6.15 mmol, 1 eq) in acetonitrile (50 ml) is treated with a solution of N-bromosuccinimide (1.8 g, 10 mmol, 1.5 eq) in acetonitrile (10 ml) and the resulting solution is stirred 2 h at room temperature and 2 h at 60 0C. After cooling, the mixture is concentrated to dryness. The residue is taken up with ethyl acetate, washed with water, dried over magnesium sulfate and concentrated under reduced pressure. Purification of the residue over silicagel (eluent: dichloromethane/benzine) affords 0.6 g of methyl 2-[3- bromo-4-(3-chloropropoxy) phenyl]-4-methyl-l,3-thiazole-5-carboxylate i91. Yield: 24 %. LC-MS (MH+): 404/406/408.
15.2 Synthesis of methyl 2-{3-bromo-4-[3-(2-methyl-l-pyrrolidinyl)propoxy] phenyl}'4-methyl-l,3-thiazole-5-carboxylate 126.
A suspension of methyl 2-[3-bromo-4-(3-chloropropoxy)phenyl]-4-methyl-l,3- thiazole-5-carboxylate i91 (0.5 g, 1.24 mmol, 1 eq), 2-methylpyrrolidine (0.3 ml, 3.0 mmol, 2.5 eq), potassium carbonate (0.68 g, 5 mmol, 4 eq) and sodium iodide (20 μg, 0.12 mmol, 0.1 eq) in acetonitrile (10 ml) is stirred overnight at 90 °C. The resulting mixture is taken up with dichloromethane, washed with water, dried over magnesium sulfate and concentrated under reduced pressure. The crude product is triturated in diethyl ether to afford 50 mg of methyl 2-{3-bromo-4-[3-(2-methyl-l-pyrrolidinyl)propoxy]phenyl}-4- methyl-l,3-thiazole-5-carboxylate l26.
Yield: 8 %.
LC-MS (MH+): 453/455. Compound 100 of table I may be synthetized according to similar experimental conditions.
Example 16. Synthesis of methyl4-[(benzylamino) methyl] -2-{4-[3-(2-methyl-l- pyrrolidinyl)propoxy] phenyl}- l,3-oxazole-5-carboxylate 99.
Figure imgf000117_0001
16.1 Synthesis of a 1:1 mixture of methyl 4-(bromomethyl)-2-[4-(3- chloropropoxy)phenyl]-l, 3-oxazole-5-carboxylate i92 and methyl 4-(bromomethyl)-2-[4- (3-chloropropoxy)phenyl]-l, 3-oxazole-5-carboxylate i93.
A solution of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5- carboxylate ax60 (1.6 g, 1 eq, 5.2 mmol) in acetonitrile (50 ml) is treated with N- bromosuccinimide (1.7 g, 1.7 eq, 9.6 mmol). The mixture is stirred at room temperature during 6 h. The solution is then poured into diethyl ether (200 ml) and is washed with water and with diluted sodium bicarbonate. The organic layer is dried over magnesium sulfate and concentrated under reduced pressure. Purification over silicagel (eluent: ethyl acetate/benzine) gives 0.6 g of a 1:1 mixture of methyl 4-(bromomethyl)-2-[4-(3- chloropropoxy)phenyl]-l,3-oxazole-5-carboxylate i92 and ethyl 4-(bromomethyl)-2-[4-(3- chloropropoxy)phenyl]-l,3-oxazole-5-carboxylate i93.
Yield: 32 %. i92: LC-MS (MH+): 388/390/392. i93: LC-MS (MH+): 402/404/406. 16.2 Synthesis of methyl 4-[(benzylamino)methyl]-2-[4-(3-chloropropoxy) phenyl] -1, 3-oxazole-5-carboxylate i94.
A solution of the 1:1 mixture of i92 and i93 (0.35 g, 0.9 mmol, 1 eq) in acetonitrile (10 ml) is added dropwise to a suspension of benzyl amine (0.1 ml, 0.9 mmol, 1 eq) and potassium carbonate (0.3 g, 2.26 mmol, 2.5 eq) in acetonitrile (10 ml). The resulting mixture is stirred overnight. It is then diluted by diethyl ether, and washed by water and brine. The organic layer is dried over magnesium sulfate, concentrated under reduced pressure and purified over silicagel (eluent: dichloromethane/methanol/ammonia 95/5/0.5) to yield 110 mg of methyl 4-[(benzylamino)methyl]-2-[4-(3-chloropropoxy)phenyl]-l,3- oxazole-5-carboxylate i94.
Yield: 29 %.
LC-MS (MH+): 415/417.
16.3 Synthesis of methyl 4-[(benzylamino)methyl]-2- {4-[3-(2-methyl-l-pyrrolidinyl) propoxy] phenyl}-!, 3-oxazole-5-carhoxylate 99.
A suspension of methyl 4-[(benzylamino)methyl]-2-[4-(3-chloropropoxy)phenyl]- l,3-oxazole-5-carboxylate i94 (0.11 g, 0.27 mmol, 1 eq), 2-methylpyrrolidine (30 μl, 0.32 mmol, 1.2 eq) and potassium carbonate (0.15 g, 1.06 mmol, 4 eq) in acetonitrile (5 ml) is stirred at 110 °C overnight. The mixture is then poured into ethyl acetate (50 ml) and washed with water. The organic layer is dried over magnesium sulfate and concentrated under reduced pressure. Two successive purifications over silicagel (eluent: dichloromethane, methanol, ammonia 90/10/1) and one purification by preparative liquid chromatography (gradient: acetonitrile/water/trifluoroacetic acid 95:5:01 to 5:95:01) yield 6 mg of methyl 4-[(benzylamino)methyl]-2-{4-[3-(2-methyl-l-pyrrolidinyl)propoxy] phenyl} - 1 ,3-oxazole-5-carboxylate 99. Yield: 5 %. LC-MS (MH+): 464. Example 17. Synthesis of2-{4-[3-(2-methyl-l-pyrrolidinyl)propoxy]phenyl}-4-(piperidin-l- yhnethyl)-!, 3-oxazole-5-carboxylic acid 101.
Figure imgf000119_0001
17.1 Synthesis of ethyl 2-[4-(3-chloropropoxy)phenyl]-4-(piperidin-l-ylmethyl)- l,3-oxazole-5-carboxylate i95.
A suspension of piperidine (90 μl, 0.86 mmol, 1.1 eq) and potassium carbonate (0.43 g, 3 mmol, 4 eq) in acetonitrile (5 ml) is treated dropwise with a solution of ethyl 4- (bromomethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-5-carboxylate i93 (0.30 g, 0.77 mmol, 1 eq) in acetonitrile (2 ml) and is stirred at room temperature overnight. Diethyl ether is then added and the solution is washed with water, dried over magnesium sulfate and concentrated under reduced pressure to give 210 mg of crude ethyl 2-[4-(3- chloropropoxy)phenyl]-4-(piperidin-l-ylmethyl)-l,3-oxazole-5-carboxylate i95, used as such in the next step.
Yield: 69 %.
LC-MS (MH+): 407/409.
17.2 Synthesis of ethyl 2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-4- (piperidin-l-ylmethyl)-l, 3-oxazole-5-carboxylate i96.
A solution of ethyl 2-[4-(3-chloropropoxy)phenyl]-4-(piperidin-l-yhnethyl)-l,3- oxazole-5-carboxylate i95 (0.22 g, 0.56 mmol, 1 eq) in acetonitrile (10 ml) is treated with potassium carbonate (0.31 g, 2.24 mmol, 4 eq) and 2-methylpyrrolidine (60 μl, 0.67 mmol, 1.2 eq) and the resulting mixture is stirred at 110 °C overnight. Ethyl acetate is then added and the organic layer is washed with water, dried over magnesium sulfate and concentrated under reduced pressure. Purification over silicagel (eluent: dichloromethane/methanol/ammonia) affords 90 mg of ethyl 2-{4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -4-(piperidin- 1 -ylmethyl)- 1 ,3-oxazole-5-carboxylate i96. Yield: 36 %. LC-MS (MH+): 456.
17.3 Synthesis of 2- {4-[3-(2-methyl-l-pyrrolidinyl)propoxy]phenyl}-4- (piperidinyl-l-methyl)-l,3-oxazole-5-carboxylic acid 101.
A solution of ethyl 2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]pheiiyl}-4-(piperidin- l-ylmethyl)-l,3-oxazole-5-carboxylate i96 (0.1 g, 0.22 mmol, 1 eq) in methanol (5 ml) is treated with 1 M sodium hydroxide (2 ml, 2 mmol, 10 eq) and the mixture is heated at 40 0C during 1 h. Methanol is then evaporated under reduced pressure and 1 M hydrochloric acid (2 ml) is added. The solution is concentrated under reduced pressure. Purification by preparative liquid chromatography (gradient: acetonitrile/water/trifluoroacetic acid 95:5:01 to 5:95:01) provides, after lyophilisation, 45 mg of 2-{4-[3-(2-methyl-l- pyrrolidinyl)propoxy]phenyl} -4-(piperidinyl- 1 -methyl)- 1 ,3-oxazole-5-carboxylic acid 101.
Yield: 50 %.
LC-MS (MH+): 428.
Example 18. Synthesis of4-[(4-methyl-2-{6-[3-(2-methylpyrrolidin-l-yl)propoxy]pyridin-3- ylj-1, 3-thiazol-5-yl)carbonyl]morpholine 147.
Figure imgf000120_0001
18.1 Synthesis of ethyl 2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazole-5- car boxy late i97.
Ethyl 2-bromo-4-methyl-l,3-thiazole-5-carboxylate (1 g, 1.3 eq, 4 mmol) is added to a mixture of 2-chloro-5 -pyridine boronic acid (0.48 g, 1 eq, 3.07 mmol), tetrakis(triphenylphosphine)palladium (0.18 g, 0.05 eq, 0.15 mmol) and an aqueous solution of 2 Mpotassium carbonate (3 ml, 2 eq, 6.14 mmol) in toluene/ethanol (18 ml, 2:1 v/v). The mixture is refluxed overnight and the solvent is evaporated, then taken up in ethyl acetate, and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chromatography over silicagel (eluent: dichloromethane 100 %) affords 0.6 g of ethyl 2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazole-5-carboxylate i97.
Yield: 69 %. LC-MS (MH+): 283/285.
18.2 Synthesis of 2-(6-chloropyridin-3-yl)-4-methyl-l , 3-thiazoleS-carboxylic acid i98.
A mixture of ethyl 2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazole-5-carboxylate i97 (0.55 g, 1 eq, 1.94 mmol) and lithium hydroxide monohydrate (0.16 g, 2 eq, 3.89 mmol) in tetrahydrofurane/water (28 ml 1:0.1, v/v) is stirred at room temperature for lh30. The mixture is diluted with water and extracted with ethyl acetate. The aqueous layer is then acidified to pH 2 with 2 N hydrochloric acid. The precipitate that forms is filtered and washed with water to give 0.48 g of 2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazole-5- carboxylic acid i98. Yield: 98 %. LC-MS (MH+): 253/255.
18.3 Synthesis of 4- {[2-(6-chloropyridin-3-yl)-4-methyl-l, 3-thiazol-5- yl] carbonyl}morpholine i99.
A mixture of ethyl 2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazole-5-carboxylate i98 (0.47 g, 1 eq, 1.84 mmol), morpholine (0.19 g, 1.2 eq, 2.21 mmol) and triethylamine (0.5 ml, 2 eq, 3.68 mmol) in dichloromethane (15 ml) is cooled to 0 0C. iV-(3- dimethylaminopropyl)-iV-ethylcarbodiimide hydrochloride (0.39 g, 1.1 eq, 2.02 mmol) and 1-hydroxybenzotriazole (0.05 g, 0.2 eq, 0.37 mmol) are then added to the solution and the mixture is stirred 24 h at room temperature. The mixture is then washed with water and a saturated solution of aqueous ammonium chloride. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum to give 0.53 g of 4-{[2-(6- chloropyridin-3-yl)-4-methyl- 1 ,3-thiazol-5-yl]carbonyl}moφholine i99. Yield: 90 %.
LC-MS (MH+): 324/326.
18.4 Synthesis of 4-[(4-methyl-2-{6-[3-(2-methylpyrrolidin-l-yl)propoxy]pyridin- 3-yl}-l ,3-thiazol-5-yl)carbonyl] morpholine 147. Sodium hydride 60% in oil (0.11 g, 2.2 eq, 2.82 mmol) is added to a mixture of 3- (2-methyl-l-pyrrolidinyl)-l-propanol (0.31 g, 2.2 eq, 2.18 mmol) in dimethylformamide (15 ml) cooled to 0 °C. The mixture is stirred at 22 °C for 20 min, and cooled again to 0 °C. 4-{[2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazol-5-yl]carbonyl}moφholine i99 (0.415 g, 1 eq, 1.28 mmol) is then added to the solution and the mixture is stirred 48 h at room temperature. The solvent is evaporated, and the residue is taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum. Purification by chomatography over silicagel (eluent: dichloromethane/methanol/ammonia 97/2.7/0.3) affords 0.047 g of 4-[(4-methyl-2-{6-[3-(2-methylpyrrolidin-l-yl)propoxy]ρyridin-3-yl}- l,3-thiazol-5-yl)carbonyl]morpholine l47.
Yield: 8 %.
LC-MS (MH+)^l.
Example 19. Synthesis of2-methyl-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}- 1, 3-oxazol-4-yl)methyl]-2H-tetraazol-5-amine 139.
Figure imgf000122_0001
19.1 Synthesis of 2-[4-(3-chloro-propoxy)-phenyl] -oxazole-4-carbaldehyde UOO.
A cold (-20 0C) solution of anhydrous trimethylamine iV-oxide (2.10 g, 27.96 mmol) in a dry mixture of dichloromethane and dimethylsulfoxide (20 ml, 1/3 v/v) is treated with a solution of 4-chloromethyl-2-[4-(3-chloro-propoxy)-phenyl]-oxazole ax57 (2.00 g, 6.99 mmol) in the same mixture of solvents (20 ml). The mixture is then allowed to warm up to 20 °C and is stirred at that temperature for 24 h. The dark mixture is then poured into water (50 ml) and extracted with dichloromethane. The organic phases are concentrated and the resulting DMSO solution is treated with ether and water. The heterogeneous mixture is further extracted with ether (2 x 20 ml). The organic phases are then dried over magnesium sulfate and concentrated to afford 760 nig of 2-[4-(3-chloro-propoxy)-phenyl]-oxazole-4- carbaldehyde ilOO.
Yield: 41 %
LC-MS (MH+): 266/268.
19.2 Synthesis of 2-methyl-N-[(2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy] phenyl} -1, 3-oxazol-4-yl)methyl]-2H-tetraazol-5-amine 139.
A mixture of 2-[4-(3-chloro-propoxy)-phenyl]-oxazole-4-carbaldehyde ilOO (0.042 mmol), 2-methyl-2H-tetrazol-5-ylamine (4.16 mg, 0.042 mmol, 1 eq) and cyanoborohydride supported on polystyrene (26 mg, 0.1 mmol, 2.5 eq) is suspended in tetrahydrofuran (300 μl) containing 10 % acetic acid and is stirred at 65 0C overnight. The polystyrene beads are then filtered off and the resulting solution is concentrated to dryness under a stream of nitrogen and taken up in dichlorometliane (2 ml). The solution is washed with 1 M potassium hydrogenosulfate (1 ml) and concentrated under reduced pressure. The residue N-( {2-[4-(3-chloropropoxy)phenyl]- 1 ,3-oxazol-4-yl}methyl)-2-methyl-2H-tetrazol- 5-amine ilOl is then treated with a solution of 2-methylpyrrolidine (4 mg, 1 eq) in acetonitrile (300 μl). Sodium carbonate (14 mg, 0.1 mmol, 2 eq) and sodium iodide (15 mg, 0.1 mmol, 2 eq) are added and the suspension is stirred overnight at 80 0C. Water (1 ml) is then added and the mixture is extracted with dichloromethane (2 x 1 ml). The organic phases are concentrated and purified by preparative liquid chromatography (gradient: acetonitrile/water/hydrogen carbonate) to afford 2-methyl-N-[(2-{4-[3-(2-methylpyrrolidin- l-yl)propoxy]phenyl} -l,3-oxazol-4-yl)methyl]-2H-tetraazol-5-amine 139.
LC-MS (MH+): 398.
Compounds 115, 140, 141 and 142 of table I may be synthetized according to similar experimental conditions.
Example 20. Synthesis of l-(3-{4-[4-methyl-5-(2-oxo-2-piperidin-l-ylethyl)-l,3-thiazol-2- yl]phenoxy}propyl)piperidine 127 and l-(3-{4-[4-methyl-5-(2-piperidin-l-ylethyl)-l,3- thiazol-2-yl]phenoxy}propyl)piperidine l36.
Figure imgf000124_0001
20.1 Synthesis of ethyl {2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5- y I /acetate H 02.
A mixture of ethyl 3-bromo-4-oxopentanoate (2 g, 8.98 mmol, 1 eq), and 4-(3- chloropropoxy)benzenecarbothioamide ax71 (2.06 g, 8.97 mmol, 1 eq) in dimethylformamide (4 ml) is stirred at 100 0C for 2 h. The reaction mixture is then added to ethyl acetate (200 ml) and the precipitate filtered off. The organic layer is washed with water (4 x 100 ml), brine, dried over magnesium sulfate and filtered. The solvent is removed under reduced pressure. Purification by chromatography over silicagel (eluent: benzine/ethyl acetate 95:5 to 85:15) affords 1.3 g of ethyl {2-[4-(3-chloropropoxy)phenyl]- 4-methyl-l,3-thiazol-5-yl}acetate il02. Yield: 40 %.
LC-MS (MH+): 354/356.
20.2 Synthesis of {2-[4-(3-chloropropoxy)phenyl] -4-tnethyl-l ,3-thiazol-5- yljacetic acid H03. A mixture of ethyl {2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5- yl}acetate ilO2 (0.5 g, 1.41 mmol, 1 eq) and sodium hydroxide (0.2 g, 5 mmol, 3.5 eq) in ethanol (15 ml) is stirred at 60 0C for lh30. A l N hydrochloric acid solution (6 ml) is added and ethanol is removed under vacuum. The residue is dissolved in ethyl acetate (200 ml). The organic layer is washed with water (2 x 50 ml), brine, dried over magnesium sulfate, filtered and concentrated to yield 0.5 g of {2-[4-(3-chloropropoxy)phenyi]-4- methyl-l,3-thiazol-5-yl}acetic acid ilO3 as a white solid. This solid is used as such in the next step.
20.3 Synthesis of l-({2-[4-(3-chloropropoxy)phenyl] -4-methyl-l ,3-thiazol-5- yl}acetyl)piperidine U04.
A solution of {2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}acetic acid ilO3 (0.5 g, 1.41 mmol, 1 eq), triethylamine (0.2 ml, 1.41 mmol, 1 eq), and piperidine (0.15 ml, 1.45 mmol, 1.03 eq) in dichloromethane (30 ml) is cooled (ice bath) and treated with 1- hydroxybenzotriazole (38 mg, 0.28 mmol, 0.2 eq) and N-(3-dimethylaminopropyl)-N'- ethylcarbodiimide (0.271 g, 1.41 mmol, 1 eq). The mixture is stirred at room temperature overnight, then diluted with 70 ml of dichloromethane. The organic layer is washed with water (2 x 50 ml), brine, dried over magnesium sulfate and filtered. The solvent is removed under reduced pressure to obtain an orange solid. The solid is triturated in acetonitrile, filtered and rinsed with cold diethyl ether to give 0.18 g of l-({2-[4-(3- chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}acetyl)piρeridine ilO4 as a yellow solid. Yield: 39 %.
1H NMR (CDCI3) δ (ppm): 1.56 (m, 5 H), 1.64 (m, 2 H), 2.25 (t, 6.05 Hz, 2 H), 2.41 (s Hz, 3 H), 3.47 (m, 2 H), 3.60 (m, 2 H), 3.75 (td, 6.23, 1.33 Hz, 2 H), 3.80 (s, 2 H), 4.15 (m, 2 H), 6.92 (d, 8.7 Hz 2 H), 7.82 (d, 8.7 Hz, 2 H).
20.4 Synthesis of l-(3-{4-[4-methyl-5-(2-oxo-2-piperidin-l-ylethyl)-l,3-thiazol-2- yl]phenoxy}propyl)piperidine 127. A suspension of l-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5- yl}acetyl)piperidine ilO4 (0.18 g, 0.51 mmol, 1 eq), potassium carbonate (0.14 g, 1.02 mmol, 2 eq) and sodium iodide (16 mg, 0.03 mmol, 0.2 eq) in acetonitrile (3 ml) is stirred at 80 °C for 20 minutes before addition of piperidine (0.15 ml, 0.51 mmol, 1.03 eq). The mixture is then stirred at reflux overnight, concentrated under vacuum and the residue is taken up in ethyl acetate (50 ml). The organic layer is washed with water (3 x 25 ml), brine, dried over magnesium sulfate and filtered. The solvent is removed under reduced pressure to obtain an orange solid. Purification by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 90:10:1) affords 150 mg of l-(3-{4-[4-methyl-5-(2- oxo-2-piperidin- 1 -ylethyl)- 1 ,3-thiazol-2-yl]phenoxy}propyl)piperidine 127. Yield: 67 %. LC-MS (MH+): 442.
20.5 Synthesis of 1-(S- {4-[4-methyl-5-(2-piperidin-l-ylethyl)-l, 3-thiazol-2- yl]phenoxy}propyl)piperidine l36.
A suspension of lithium aluminium hydride (0.14 g, 3.68 mmol, 5.2 eq) in tetrahydrofuran (10 ml) at -78 0C is treated with l-(3-{4-[4-methyl-5~(2-oxo-2-piperidin-l- ylethyl)-l,3-thiazol~2-yl]phenoxy}propyl)piperidine 127 (0.31 g, 0.7 mmol, 1 eq). The mixture is allowed to warm up and stirred at room temperature overnight. Sodium sulfate decahydrate (3.68 g) is then added and the mixture is stirred for a further 3 h. The mixture is filtered on magnesium sulfate and concentrated. Two purifications by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 90:10:1), afford 55 mg of l-(3- {4-[4-methyl-5-(2-piperidin- 1 -ylethyl)- 1 ,3-thiazol-2-yl]phenoxy}propyl)piperidine 136.
Yield: 16 %.
LC-MS (MH+): 428.
Example 21. Synthesis of (4-methyl-2-{4-[3-(2-methyl-pyrrolidin-l-yl)-propoxy]-phenyl}- thiazol-5-yl)-morpholin-4-yl-methanone 152.
Figure imgf000126_0001
21.1 Synthesis of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5- car boxy late H 05.
A mixture of 4-(3-chloropropoxy)benzenecarbothioamide ax71 (34.67 mmol, 1 eq, 7.96 g), and 2-chloroacetoacetic acid methyl ester (34.67 mmol, 1 eq, 5.2 g) in methanol is stirred at 70 0C for 2 hours. The reaction mixture is then poured into a sealed tube and stirred at 100 0C for 3 hours. The mixture is taken up in dichloromethane and washed with water then dried over magnesium sulfate. The solvent is removed under reduced pressure to give 11.8 g of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5-carboxylate Ϊ105. The product is used as such in the next step.
Yield: 100 %.
LC-MS (MH+): 325/327.
21.2 Synthesis of 2-[4-(3-chloropropoxy)phenyl] -4-methyl-l , 3-thiazole-5- carboxylic acidilOό.
A mixture of 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5-carboxylate ilO5 (14.1 mmol, 1 eq, 4.6 g) and 2 M sodium hydroxide (28.2 mmol, 2 eq, 14.1 ml) in methanol (100 ml) is stirred at 70 0C overnight. The mixture is concentrated to dryness and taken up in a minimum of water. The aqueous phase is acidified by 1 N hydrogen chloride to reach pH 2 and poured into ice to afford precipitation of a white solid. The solid is filtered and dried under reduced pressure to give 3.9 g of 2-[4-(3-chloropropoxy)phenyl]-4- methyl-l,3-thiazole-5-carboxylic acid ilO6 as a white solid. This solid is used as such in the next step.
Yield: 89 %.
LC-MS (MH+): 312/314.
21.3 Synthesis of 4-({2-[4-(3-chloropropoxy)phenyl] -4-methyl-l ,3-thiazol-5- yl}carbonyl)morpholine H07.
To a solution of 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5-carboxylic acid ilO6 (1.6 mmol, 1 eq, 0.5 g), triethylarnine (3.2 mmol, 2 eq, 0.45 ml) in dichloromethane (20 ml) is added 1-hydroxybenzotriazole (0.32 mmol, 0.2 eq, 43 mg), N- (3-dimethylaminopropyl)-7V'-ethylcarbodiimide (1.76 mmol, 1.1 eq, 0.33 g) and rnorpholine (1.92 mmol, 1.2 eq, 0.17 g). The mixture is stirred at room temperature overnight. The organic layer is washed with water and with a saturated aqueous solution of ammonium chloride, then dried over magnesium sulfate and filtered. The solvent is removed under reduced pressure. The crude product is purified by flash chromatography over silicagel (eluent: dichloromethane/ethanol 99:1 to 95:5) to afford 380 mg of 4-({2-[4- (3-chloropropoxy)phenyl]-4-methyl- 1 ,3 -thiazol-5-yl} carbonyl)morpholine ilO7.
Yield: 63 %.
LC-MS (MH+): 381/383. l-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}carbonyl)-4,4- difiuoropiperidine ilO8 may be synthesized according to the same method. LC-MS (MH+): 415/417.
21.4 Synthesis of 4-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}- 1, 3-thiazol-5-yl)carbonyl]morpholine 152. To a solution of 4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5- yl}carbonyl)morpholine ilO7 (1.0 mmol, 1 eq, 0.38 g) in acetonitrile (10 ml), is added potassium carbonate (1.99 mmol, 2 eq, 0.27 g) and approximatively 0.01 g of sodium iodide. The mixture is stirred at 80 °C for 30 minutes in a sealed tube before addition of 2- methylpyrrolidine (1.2 mmol, 1.2 eq, 0.12 ml). The mixture is then stirred at 80 0C overnight. The mixture is taken up in ethyl acetate and washed with a saturated solution of sodium bicarbonate, then dried over magnesium sulfate. The solvent is removed under reduced pressure and purified by chromatography over silica gel (eluent: dichloromethane/methanol/ammonia 96:3.6:0.4) to give 0.132 g of 4-[(4-methyl-2-{4-[3- (2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazol-5-yl)carbonyl]morpholine 152 as a yellow oil.
Yield: 31 %. LC-MS (MH+): 430.
Compounds 149, 150, 151, 153 and 154 of table I maybe synthetized according to similar experimental conditions.
Example 22. Synthesis of l-(3-{2-fluoro-4-[4-(piperidin-l-ylmethyl)-l ,3-oxazol-2- yl]phenoxy}propyl)piperidine 88.
Figure imgf000128_0001
To a solution of triphenylphosphine (0.81 g, 3.08 mmol, 1 eq) in dry tetrahydrofuran at 0 °C is added dropwise diisopropylazodicarboxylate (0.61 ml, 3.08 mmol, 1 eq). A solution of 2-fluoro-4-[4-(l-piperidinylmethyl)-l,3-oxazol-2-yl]phenol i68 (0.85 g, 3.08 mmol, 1 eq) and 3-(l-piperidinyl)-l-propanol (0.44 g, 3.08 mmol, 1 eq) in tetrahydrofuran is added dropwise to the mixture at O0C. After 2 days, the mixture is poured onto 0.5 N hydrochloric acid and extracted with diethyl ether. The aqueous phase is basified with 1 N sodium hydroxide to pH 9 and extracted with ethyl acetate. The organic layer is dried on magnesium sulfate and concentrated under reduced pressure. The crude product is purified by chromatography over silica gel to afford 0.25 g of l-(3-{2-fluoro-4-[4-(piperidin-l- ylmethyl)-l,3-oxazol-2-yl]phenoxy}propyl)piperidine 88 as a yellow oil.
Yield: 20 %.
LC-MS (MH+): 371.
Example 23. Synthesis of l-[(4-methyl-2- {4-[3-(2-methyl-l-pyt"rolidinyl)propoxy]phenyl}- 1, 3-thiazol-5-yl)methyl]-2-pyrrolidinone trifluoroacetate 156.
Figure imgf000129_0001
23.1 Synthesis of {2-[4-(3-chloropropoxy)phenyl] -4-methyl-l , 3-thiazol-5- yljmethanol H09.
To a solution of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5- carboxylate ilO5 (6.13 mmol, 1 eq, 2 g) in tetrahydrofuran- (60 ml) is added methanol (19.6 mmol, 3.2 eq, 0.8 ml) and lithium borohydride (13.49 mmol, 2.2 eq, 0.29 g). The mixture is stirred at 75 °C overnight. 1 N aqueous hydrogen chloride (2 ml) is added and the mixture is then stirred at room temperature for 1 hour. Then, a 2 M aqueous sodium hydroxide solution is added to reach pH 12 and the mixture is stirred for 6 hours, then extracted twice with ethyl acetate. The organic layer is dried over magnesium sulfate and the solvent is removed under reduced pressure to give 1.65 g of {2-[4-(3-chloropropoxy)phenyl]-4- methyl-l,3-thiazol-5-yl}methanol ilO9 as a white solid.
Yield: 91 %.
LC-MS (MH+): 298.
23.2 Synthesis of l-({2-[4-(3-chloropropoxy)phenyl] -4-methyl-l , 3-thiazol-5- yl}methyl)pyrrolidin-2-one illO. In a flask fitted with a magnetic stirrer and a reflux condenser, {2-[4-(3- chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}methanol ilO9 (0.67 mmol, 1 eq, 0.2g), pyrrolidinone (0.8 mmol, 1.2 eq, 0.069 g) and p-toluenesulfonic acid (0.067 mmol, 0.1 eq, 0.013 g) are dissolved in toluene (5 ml) and the mixture is brought to reflux overnight. After this time, the mixture is concentrated, taken up in ethyl acetate and washed with a saturated solution of sodium bicarbonate. The organic layer is dried over magnesium sulfate and concentrated to dryness to give 0.295 g of l-({2-[4-(3-chloropropoxy)phenyl]- 4-methyl-l,3-thiazol-5-yl}methyl)pyrrolidin-2-one illO. This crude product is used in the next step without further purification. Yield: 100 %.
LC-MS (MH+): 365.
23.3 Synthesis of l-[(4-methyl-2-{4-[3-(2-methyl-l-pyrrolidinyl)propoxy]phenyl}- 1, 3-thiazol-5-yl)methyl]-2-pyrrolidinone trifluoroacetate 156. To a solution of l-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5- yl}methyl)pyrrolidin-2-one illO (1.0 mmol, 1 eq, 0.36 g) in acetonitrile (10 ml) is added potassium carbonate (1.99 mmol, 2 eq, 0.27 g) and approximatively 0.01 g of sodium iodide. The mixture is stirred at 80 °C for 30 minutes in a sealed tube before addition of 2- methylpyrrolidine (1.2 mmol, 1.2 eq, 0.12 ml). The mixture is then stirred at 80 0C overnight. The mixture is taken up in ethyl acetate and washed with a saturated solution of sodium bicarbonate, then dried over magnesium sulfate. The solvent is removed under reduced pressure and purified by chromatography over silicagel (eluent: dichloromethane/methanol/ammonia 96:3.6:0.4) then by preparative liquid chromatography (gradient: acetonitrile/water/trifluoroacetic acid 95:5:0.1 to 5:95:0.1) to give 0.132 g of 1- [(4-methyl-2-{4-[3-(2-methyl-l-pyrrolidinyl)propoxy]phenyl}-l,3-thiazol-5-yl)methyl]-2- pyrrolidinone trifluoroacetate 156. Yield: 15.5 %. LC-MS (MH+): 414. Example 24. Synthesis of4-({(2S)-l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}- l,3-oxazol-4-yl)methyl]pyrrolidin-2-yl}methyl)morpholine 144.
Figure imgf000131_0001
(5S)- 1 -[(2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]-5-(moφholin-4-ylmethyl)pyrrolidin-2-one 137 (0.21 g, 1 eq, 0.43 mmol) is dissolved in tetrahydrofiαran (5 ml), then the mixture is cooled to 0 0C and lithium aluminium hydride (0.03 g, 2 eq, 0.87 mmol) is added. The mixture is stirred 1 h at 0 0C and then overnight at room temperature. Water (0.05 ml), a solution of sodium hydroxyde 2N (0.05 ml) and again water (0.15 ml) are added. Then, the mixture is filtered through celite and concentrated under vacuum. Purification by chromatography on silicagel (eluent: dichloromethane/methanol/ammonia 95/5/0.5) affords 0.058 g of 4-({(2S)-l-[(2-{4-[3-(2- methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4-yl)methyl]pyrrolidin-2- yl}methyl)morpholine 144.
Yield: 29 % LC-MS (MH4): 469
Table I gives characteristics of some compounds of general formula (I). Said table indicates the stereochemical information in the columns headed "configuration": the second one indicates whether a compound has no stereogenic center (achiral), is a pure enantiomer (pure), a racemate (rac) or is a mixture of two stereoisomers, possibly in unequal proportions (mixture); the first one contains the stereochemical assignment for the recognized center, following the IUPAC numbering used in the "IUPAC name" column. A number alone indicates the existence of both configurations at that center. A number followed by 'R' or 'S' indicates the known absolute configuration at that center. Table 1 indicates also the type and stoechiometry of salt, which was synthesized (if not the free base), the IUPAC name of the compound, the ion peak observed in mass spectrometry, the ^H NMR description and the optical rotation in the case of enantiomerically pure compounds. Table I
Figure imgf000132_0001
Figure imgf000133_0001
Figure imgf000134_0001
Figure imgf000135_0001
Figure imgf000136_0001
Figure imgf000137_0001
Figure imgf000138_0001
Figure imgf000139_0001
Figure imgf000140_0001
Figure imgf000141_0001
Figure imgf000142_0001
Figure imgf000143_0001
Figure imgf000144_0001
Figure imgf000145_0001
Figure imgf000146_0001
Figure imgf000147_0001
Figure imgf000147_0002
Figure imgf000148_0001
Figure imgf000149_0001
Figure imgf000150_0001
Figure imgf000151_0001
Figure imgf000152_0001
Figure imgf000153_0001
Figure imgf000154_0001
Figure imgf000155_0001
Figure imgf000156_0001
Figure imgf000157_0001
Figure imgf000158_0001
Figure imgf000159_0001
Example 25 - Affinity for the Histamine Hβ-receptor; Inverse agonism, antagonism and agonism activity: f^^SJGTPyS-binding assay human Histamine Hβ-receptor. Material and methods Reagents Reagents and reference compounds were of analytical grade and obtained from various commercial sources. [3H]-N-α-methylhistamine (80-85 Ci/mmol) and [35S]-GTPγS (1250 Ci/mmol) were purchased from Perkin Elmer (Belgium). Cell culture reagents were purchased from Cambrex (Belgium). Test and reference compounds were dissolved in 100 % DMSO to give a 1 mM stock solution. Final DMSO concentration in the assay did not exceed 1 %.
A CHO cell line expressing the human H3 histamine receptor (sequence as published by Lovenberg et al. in MoI. Pharmacol. 1999, 55, 1101-1107) was purchased from Euroscreen S.A. (Belgium). Cell culture Cells were grown in HAM-F 12 culture media containing 10 % fetal bovine serum, 100 IU /ml penicillin, 100 μg/ml streptomycin, 1 % sodium pyruvate and 400 μg/ml of gentamycin. Cells were maintained at 37 0C in a humidified atmosphere composed of 95 % air and 5 % CO2. Membrane preparation Confluent cells were detached by 10 min incubation at 37 °C in PBS / EDTA 0.02 %. The cell suspension was centrifuged at 1,500 x g for 10 min at 4 0C. The pellet was homogenized in a 15 mM Tris-HCl buffer (pH 7.5) containing 2 mM MgQ.2, 0.3 mM EDTA, 1 mM EGTA (buffer A). The crude homogenate was frozen in liquid nitrogen and thawed. DNAse (lμl/ml) was then added and the homogenate was further incubated for 10 min at 25 °C before being centrifuged at 40,000 x g for 25 min at 4 °C. The pellet was resuspended in buffer A and washed once more under the same conditions. The final membrane pellet was resuspended, at a protein concentration of 1-3 mg / ml, in a 7.5 mM Tris-HCl buffer (pH 7.5) enriched with 12.5 mM MgCl2, 0.3 mM EDTA, 1 mM EGTA and 250 mM sucrose and stored in liquid nitrogen until used. Binding assays
[3H1-N-α-methylhistamine binding assay
Affinity of compounds for human H3 histamine receptors was measured by competition with [3H]-N-α-methylhistamine. This binding assay was performed essentially as described by Lovenberg et al.(Mol. Pharmacol. 1999, 55, 1101-1107) and Tedford et al. (J. Pharmacol. Exper. Ther. 1999, 289, 1160-1168) with minor modifications. Briefly, membranes (20-40 μg proteins) expressing human H3 histamine receptors were incubated at 25 0C in 0.5 ml of a 50 mM Tris-HCl buffer (pH 7.4) containing 2 mM MgCl2, 0.2 nM [3H]-N-α-methylhistamine and increasing concentrations of drugs. The non specific binding (NSB) was defined as the residual binding observed in the presence of 10 μM thioperamide or histamine. Membrane-bound and free radioligand were separated by rapid filtration through glass fiber filters presoaked in 0.1 % PEL Samples and filters were rinsed by at least 6 ml of ice-cold 50 mM Tris-HCl buffer (pH 7.4). The entire filtration procedure did not exceed 10 seconds per sample. Radioactivity trapped onto the filters was counted by liquid scintillation in a β-counter.
[35Sl-GTPγS binding assay
Stimulation (agonist) or inhibition (inverse agonist) of [^ 5 S]-GTPyS binding to membrane expressing human H3 histamine receptors was measured as described by Lorenzen et al. (MoI. Pharmacol. 1993, 44, 115-123) with a few modifications. Briefly, membranes (10-20 μg proteins) expressing human H3 histamine receptors were incubated at 25 °C in 0.2 ml of a 50 mM Tris-HCl buffer (pH 7.4) containing 3 mM MgCl2, 50 mM NaCl, 1 μM GDP, 2 μg saponin and increasing concentrations of drugs. After 15 min preincubation, 0.2 nM of [35s]-GTPγS were added to the samples. The non specific binding (NSB) was defined as the residual binding observed in the presence of 100 μM Gpp(NH)p. Membrane-bound and free radioligand were separated by rapid filtration through glass fiber filters. Samples and filters were rinsed by at least 6 ml of ice-cold 50 mM Tris-HCl buffer (pH 7.4). The entire filtration procedure did not exceed 10 seconds per sample. Radioactivity trapped onto the filters was counted by liquid scintillation in a β-counter.
Data analysis
Determination of PIC50 / pKi / PEC50 / PEC50INV
Analysis
Raw data are analyzed by non-linear regression using XLfit ™ (IDBS, United Kingdom) according to the following generic equation
Figure imgf000161_0001
where
B is the radioligand bound in the presence of the unlabelled compound (dpm),
MIN is the minimal binding observed (dpm)
MAX is maximal binding observed (dpm), X is the concentration of unlabelled compound (log M), pX50 (-log M) is the concentration of unlabelled compound causing 50 % of its maximal effect (inhibition or stimulation of radioligand binding). It stands for PIC50 when determining the affinity of a compound for the receptor in binding studies with [-^EQ-N-α- methylhistamine, for PEC50 for compounds stimulating the binding of [35s]-GTPγS (agonists) and for PEC50INV for compounds inhibiting the binding of [35s]-GTPγS (inverse agonists), njj is the Hill coefficient.
pKi is obtained by applying the following equation (Cheng and Prusoff, 1973, Biochem.
Pharmacol., 22 : 3099-3108): pKi = pIC50 + log ( l + L/ Kd ) where: pKi is the unlabelled compound equilibrium dissociation constant (-log M), L is the radioligand concentration (nM),
Kd is the radioligand equilibrium dissociation constant (nM).
Compounds of formula (I) according to the invention showed PIC50 values ranging from
6.5 to 10 for the histamine H3 receptor.
Some compounds of formula (I) according to the present invention show PIC50 values greater than or equal to 6.9.
Some compounds of formula (I) according to the present invention show PIC50 values greater than or equal to 7.5.
Some compounds of formula (I) according to the present invention show PIC50 values greater than or equal to 8.2. Compounds of formula (I) according to the invention showed PEC50INV values typically ranging from 6.5 to 10 for the histamine H3 receptor.
Example 26. Antagonism activity: Paced isolated guinea pig myenteric plexus — Electric- Field Stimulation assay. Material and methods Reagents
Stock solutions (10"^ M) of compounds to be tested and further dilutions were freshly prepared in DMSO (WNR, Leuven, Belgium). All other reagents (R(-)-α-methylhistamine, mepyramine, ranitidine, propranolol, yohimbine and components of the Krebs' solution) were of analytical grade and obtained from conventional commercial sources. Animals
Four week-old male Dunkin-Hartley guinea pigs (200-300 g) were supplied by Charles River (Sultfeld, Germany). All animals were ordered and used under protocol "orgisol- GP" approved by the UCB Pharma ethical committee. Animals were housed in the UCB animal facility in groups of 12, in stainless steel cages (75 x 50 x 30 cm) and allowed to acclimatise for a minimum of one week before inclusion in the study. Room temperature was maintained between 20 and 24 °C with 40 to 70 % relative humidity. A light and dark cycle of 12 h was applied. Animals had free access to food and water. Organ preparation
The method was adapted from that described by Menkveld et al. in Eur. J. Pharmacol. 1990, 186, 343-347. Longitudinal myenteric plexus was prepared from the isolated guinea pig ileum. Tissues were mounted in 20-ml organ baths containing modified Krebs' solution with 10~7 M mepyramine, 10"^ M ranitidine, 10" ^ M propranolol and 1(H> M yohimbine. The bathing solution was maintained at 37 0C and gassed with 95 % O2- 5 % CC^- Tissues were allowed to equilibrate for a 60-min period under a resting tension of 0.5 g and an electrical field stimulation (pulses of 5-20 V, 1 ms and 0.1 Hz was applied during the whole experiment). Such a stimulation induces stable and reproductive twitch contractions. Isometric contractions were measured by force-displacement transducers coupled to an amplifier connected to a computer system (EMKA Technologies) capable of controlling (i) automatic data acquisition, (U) bath washout by automatic fluid circulation through electrovalves at predetermined times or signal stability and (Ui) automatic dilution/injection of drug in the bath at predetermined times or signal stability. Protocol
After a 60 min-stabilisation period, tissues were stimulated twice with 10"" M R(-)-α- methylhistamine at 30-min interval. After a 60-min incubation period in the presence of solvent or antagonist test compound, a cumulative concentration-response to R(-)-cc- methylhistamine was elicited (10~10 a 10"^ M). Only one concentration of antagonist was tested on each tissue.
Data analysis
An appropriate estimate of interactions between agonist and antagonist can be made by studying the family of curves observed in the absence or presence of increasing antagonist concentrations. The value of each relevant parameter of each concentration-response curve (pD2 and Emax) was calculated by an iterative computer software (XLfit, IDBS, Guildford, UK) fitting the experimental data to the four parameter logistic equation. Antagonistic activity of the test substance was estimated by the calculation of pD'2 and /or pA2 values according to the methods described by Van Rossum et al. in Arch. Int. Pharmacodyn.Ther. 1963, 143, 299 and/or by Arunlakshana & Schild in Br. J. Pharmacol 1959, 14, 48
Results are expressed as the mean ± SD. The number of observations is indicated as n. Compounds of formula (I) according to the invention showed pA2 values typically greater than or equal to 6.5 for the histamine H3 receptor.

Claims

1. A compound of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000165_0001
(I) wherein
A1 is CH, C(alkyl), C-halogen or N; RI is hydrogen, halogen, C\.β alkyl or alkoxy; R2 is
Figure imgf000165_0002
(ir) ;
A3 is O or S;
R3 is hydrogen, halogen, C \.β alkyl or alkoxy; R4 is hydrogen, halogen, C\.β alkyl, alkoxy or -O-L;
R^ is hydrogen or -O-L; L is C1-6-alkyl amino;
RIO is hydrogen, sulfonyl, amino, C\.β alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, C3..8 cycloalkyl, 3-8-membered heterocycloalkyl, acyl, C1-6-alkyl aryl, C\.§- alkyl heteroaryl, C2-6-alkenyl aryl, C2-6-alkenyl heteroaryl, C2-6-alkynyl aryl, C2-6 alkynyl heteroaryl, C1-6-alkyl cycloalkyl, C1-6-alkyl heterocycloalkyl, C2-6-alkenyl cycloalkyl, C2-6-alkenyl heterocycloalkyl, C2-6-alkynyl cycloalkyl, C2-6-alkynyl heterocycloalkyl, alkoxycarbonyl, aminocarbonyl, C1-6-alkyl carboxy, C1-6-alkyl acyl, C3_g-cycloalkyl acyl, aryl acyl, heteroaryl acyl, C3_g-heterocycloalkyl acyl, C1-6-alkyl acyloxy, C1-6-alkyl alkoxy, C1-6-alkyl alkoxycarbonyl, C1-6-alkyl aminocarbonyl, C\.β- alkyl acylamino, acylamino, C1-6-alkyl ureido, C1-6-alkyl carbamate, C1-6-alkyl amino, C3-8-cycloalkyl amino, C1-6-alkyl sulfonyl, C1-6-alkyl sulfinyl, C1-6-alkyl sulfanyl, Cj_ g-alkyl sulfonylamino, C1-6-alkyl aminosulfonyl, hydroxy, halogen or cyano;
RI 1 is hydrogen, sulfonyl, amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, C3_8 cycloalkyl, 3-8-membered heterocycloalkyl, acyl, C1-6-alkyl aryl, C\.β- alkyl heteroaryl, C2-6-alkenyl aryl, C2-6-alkenyl heteroaryl, C2-6-alkynyl aryl, C2-6 alkynyl heteroaryl, C1-6-alkyl cycloalkyl, C1-6-alkyl heterocycloalkyl, C2-6-alkenyl cycloalkyl, C2-6-alkenyl heterocycloalkyl, C2-6-alkynyl cycloalkyl, C2-6-alkynyl heterocycloalkyl, alkoxycarbonyl, aminocarbonyl, C1-6-alkyl carboxy, C1-6-alkyl acyl, C3_g-cycloalkyl acyl, aryl acyl, heteroaryl acyl, C3_8-heterocycloalkyl acyl, C1-6-alkyl acyloxy, C1-6-alkyl alkoxy, C1-6-alkyl alkoxycarbonyl, C1-6-alkyl aminocarbonyl, C1-6- alkyl acylamino, acylamino, C1-6-alkyl ureido, C1-6-alkyl carbamate, C1-6-alkyl amino, C3_8-cycloalkyl amino, C1-6-alkyl sulfonyl, C1-6-alkyl sulfinyl, C1-6-alkyl sulfanyl, C\_ g-alkyl sulfonylamino, C1-6-alkyl aminosulfonyl, hydroxy, halogen or cyano; and with the proviso that when R1 1 is an alkoxycarbonyl, R4 is hydrogen, halogen, C1_
6 alkyl or alkoxy; and with the proviso that R4 is -OL, when R5 is hydrogen and that R5 is -O-L, when R4 is hydrogen, halogen, C1-6 alkyl or alkoxy.
2. A compound of formula (I) according to claim 1, geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000166_0001
(I)
wherein
A1 is CH, C(CH3), C-halogen or N;
RI is hydrogen or halogen; R2 is
Figure imgf000167_0001
A3 is O or S;
R3 is hydrogen, halogen, C 1.4 alkyl or C\ .4 alkoxy; R4 is hydrogen, halogen, C1.4 alkyl, Ci_4 alkoxy or -0-(CH^)n-NR 12aR12b;
R5 is hydrogen or -O-(CH2)m-NR13aR13b; R10 is hydrogen, Q.g alkyl or -(CH2)w-(C=O)t-NR15R16; RI 1 is hydrogen, Cj.g alkyl, ester, carboxylic acid, halogen, or -(CH2)r-(C=O)z- NR17R18; Rl2a and Rl2b ^0 linked together to form a C3..6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl;
Rl 3a and R*3b are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl, an amino group or a C^β alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a C^.g alkyl, C^-β cycloalkyl or C\_§ alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C3_g alkylene;
R!5 is hydrogen or a C^.g alkyl;
R!6 is aryl, heteroaryl, Cj.g alkyl, C\_β -alkyl cycloalkyl, C3..6 cycloalkyl, C\.β alkyl aryl or CH2-heteroaryl; or R15 and R^ are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C \.4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by an C1-6 alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C\_ 8 alkyl or a C3_g cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3_g cycloalkyl or a carbonyl and another methylene being optionally substituted by an alkylamine; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a Cβ.g alkylene; or BJ-* and Rl 6 are linked together to form with N an unsaturated 5- or 6-membered heteroaryl optionally substituted by a C 1.4 alkyl;
Rl 7 is hydrogen or a Cj_g alkyl;
R! 8 is Cj.g alkyl, C\.β alkyl aryl or C\ _g alkyl cycloalkyl; or R!7 and R!8 are linked together to form a C^-β alkylene, each methylene of the alkylene being optionally substituted by one or two Cj .4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C\_ g alkyl or C^-β cycloalkyl; n and m are independently an integer comprised between 2 and 8; w and r are independentely an integer comprised between 0 and 4; t and z are independentely an integer equal to 0 or 1 ; with the proviso that R4 is -O-(CH2)n-NR12aR12b, when R5 is hydrogen and that
R5 is -O-(CH2)m-NR13aR13b, when R4 is hydrogen, halogen, Cχ_4 alkyl or Ci_4 alkoxy; with the proviso that when Rl 1 is an ester or a carboxylic acid, R4 is hydrogen, halogen, Cj „4 alkyl or C\ .4 alkoxy; with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0.
3. A compound of formula (I) according to claim 1 or claim 2 wherein R3 is hydrogen, halogen or C 1.4 alkyl.
4. A compound of formula (I) according to claim 1 or claim 2 wherein R4 is hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or -0-(CH2VNR12aRl2b.
5. A compound of formula (I) according to claim 1 or claim 2 wherein R^ is hydrogen or - °-(CH2)m-NR13aR13b-
6. A compound of formula (I) according to any preceding claim, geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000169_0001
wherein A1 Is CH5 C(CH3X C-F OrN;
RI is hydrogen; R2 is
Figure imgf000169_0002
A3 is O or S; R3 is hydrogen, fluorine or methyl;
R^ is hydrogen, chlorine, bromine, fluorine, methyl, methoxy or -O-(CH2)n" NRl2aR12b.
R5 is hydrogen or -O-(CH2)m-NR13aR13b; R10 is hydrogen, methyl or -(CH2)w-(C=O)t-NR15R16; R11 is hydrogen, methyl, COOCH3, COOH, bromine or -(CH2)r-(C=O)z-
NR17R18;
-NR12aR12b is 1-ρyrrolidinyl;
-NR13aRl3b is selected from the group consisting of 1-piperidmyl, 1-pyrrolidinyl, 2-methylpyrrolidin-l-yl, (2S)-2-methylpyrrolidin-l-yl, (2R)-2-methylpyrrolidin-l-yl, 4- isopropylpiperazin- 1 -yl, 4-methylpiperidin- 1 -yl, 2-methylpiperidin- 1 -yl, 2-(pyrrolidin- 1 - ylmethyl)pyrrolidin- 1 -yl, 4-cyclopentylpiperazin- 1 -yl, 3 -(dimethylamino)pyrrolidin- 1 -yl, 4-(2-pyrrolidin-l-ylethyl)piperazin-l-yl, 1-azepanyl, 2,6-dimethylpiperidin-l-yl, (2S)-2- (pyrrolidin-l-yhnethyl)pyrrolidin-l-yl, 2-isobutylpyrrolidin-l-yl, 2-ethylpyrrolidinyl and (4aR, 8aS)-octahydroisoquinolin-2(lH)-yl. -NR1^RI 6 [s selected from the group consisting of 1-piperidinyl, 2- methylpyrrolidin-1-yl, 1-pyrrolidinyl, 1-azepanyl, 4-methylpiperidin- 1-yl, 2- methylpiperidin- 1 -yl, (3 ,5-dimethyl)piperidin- 1 -yl, hexyl(methyl)amino, benzyl(methyl)amino, (2-methoxy-l-methylethyl)amino, 2-azaspiro[5.5]undec-2-yl, 7,8- dimethyl-lazaspiro[4.4]non-l-yl, 2-oxopyrrolidin-l-yl, anilino, 2-methyl-lH-imidazol-l-yl, lH-l,2,4-triazol-l-yl, [l-(hydroxymethyl)-3-methylbutyl]amino, cyclopentylamino, (1,3- dimethylbutyl)amino, (cyclopropylmethyl)(propyl)amino, 2,6-dimethylpiperidin-l-yl, (2- furylmethyl)(methyl)ammo, sec-butyl(propyl)amino, 4-benzylpiperidin-l-yl, 4- cyclopentylpiperazin-1-yl, 4-moφholinyl, (4-fluorobenzyl)amino, (4-chlorobenzyl)amino, 2-oxo-piperidin- 1 -yl, (5 S)-2-oxo-(5 -pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl, (4- fluorophenyll)amino, (4aR, 8aS)-octahydroisoquinoline-2(lH)-yl, (2S)-2-(pyrrolidin-l- ylmethyl)pyrrolidin-l-yl, (2-methyl-2H-tetrazol-5-yl)amino, (3-methoxyphenyl)amino, (pyridin-3-yl)amino, (2S)-2-(morpholin-4-ylmetliyl)pyrrolidin-l-yl, (2S)-2-(morpholin-4- ylmethyl)-5-oxopyrrolidin-l-yl, benzylamino and 4,4-difluoropiperidin-l-yl.
-NR* ^RI 8 is 1-piperidinyl, 2-oxopyrrolidin-l-yl, (cyclopropylmethyl)(propyl)amino, cyclopentylamino, benzylamino, (4- cyclopentyl)piperazine-l-yl, 4-moφholinyl or (4,4-difluoro)piperidin-l-yl. n is equal to 3; m is an integer comprised between 2 and 4; w is an integer equal to 0, 1 or 2; z is an integer equal to 0 or 1 ; r is an integer equal to 0, 1 or 2; t is an integer equal to 0 or 1; with the proviso that R4 is -O-(CH2)n-NR12aR12b when R5 is hydrogen and that R5 is -O-(CH2)m-NRl3aRl3b when R4 is hydrogen, chlorine, bromine, fluorine, methyl, or methoxy; with the proviso that when R* 1 is COOCH3 or COOH, R4 is hydrogen, chlorine, bromine, fluorine, methyl, or methoxy; and with the proviso that when R10 is -(CH2)w-(C=O)t-NR15R16, R11 is hydrogen, methyl, COOCH3, COOH or bromine; and with the proviso that at least one of w and t is different from 0; and with the proviso that at least one of r and z is different from 0.
7. A compound of formula (I) according to any preceding claim wherein A* is CH or C-F
8. A compound of formula (I) according to any preceding claim wherein A* is CH.
9. A compound according to any preceding claim wherein R^ is hydrogen or methyl.
10. A compound of formula (I) according to any preceding claim wherein R^ is hydrogen, chlorine, bromine, fluorine or methoxy.
11. A compound of formula (I) according to any preceding claim wherein R^ is hydrogen or fluorine.
12. A compound of formula (I) according to any preceding claim wherein TU® is methyl or -(CH2)w-(C=O)t-NRl5Rl6.
13. A compound of formula (I) according to any preceding claim wherein RlO is methyl.
14. A compound of formula (I) according to any preceding claim wherein RI 1 is hydrogen, methyl, bromine, COOCH3 or -(CH2)r-(C=O)z-NRl7R18.
15. A compound of formula (I) according to any preceding claim wherein R* 1 is hydrogen or -(CH2V(C=O)2-NR1^R18.
16. A compound of formula (I) according to any preceding claim wherein A-* is O.
17. A compound of formula (I) according to any preceding claim wherein A^ is S.
18. A compound of formula (I) according to any preceding claim wherein t is equal to 0.
19. A compound of formula (I) according to any preceding claim wherein r is equal to 0.
20. A compound of formula (I) according to any preceding claim wherein z is to 1.
21. A compound of formula (Ii) according to claim 1 geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000172_0001
(Ii) wherein
L is C1-6-alkyl amino; w is an integer comprised between 1 and 4; and RlOa is an amino group.
22. A compound of formula (Ij) according to claim 1 geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000172_0002
(Ij) wherein
L is C1-6-aUcyl amino; and
RlOb is an amino group.
23. A compound of formula (Dc) according to claim 1 geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000172_0003
(Ik) wherein L is C1-6-alkyl amino; and RlOb is an amino group.
24. A compound according to any one of claims 21 to 23 wherein RI Oa and RlOb are independently -NRI 5Rl 6-
25. A compound of formula (II) according to claim 1, geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000173_0001
(H) wherein
L is C1-6-alkyl amino; r is an integer comprised between 1 and 4; R10c is a C1-6 alkyl; and
RI Ia is an amino group.
26. A compound of formula (Im) according to claim 1 geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000173_0002
(Im) wherein
L is C1-6~alkyl amino; r is an integer comprised between 1 and 4; R10c is a C1-6 alkyl; and Rl *a is an amino group.
27. A compound of formula (In) according to claim 1 geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000174_0001
(hi) wherein
L is C1-6-alkyl amino;
R1Oc is a C1-6 alkyl; and RI I"3 is an amino group.
28. A compound of formula (Io) according to claim 1, geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000174_0002
(Io) wherein
L is C1-6-alkyl amino;
R10c is a C1-6 alkyl; and RI Ib is an amino group.
29. A compound according to any one of claims 25 to 28 wherein Rl Ia and RI Ib are independently NRl 7R18 #
30. A compound according to any one of claims 1 or claims 21 to 29 wherein L is (CH2)m- NRBaRl 3b
31. A compound according to any preceding claim wherein -NR^aRl3b [s selected from the group consisting of 1-piperidinyl, 2-methylpyrrolidin-l-yl, (2S)-2-methylpyrrolidin- 1-yl, (2R)-2-methylpyrrolidin-l-yl, 4-methylpiperidin-l-yl, 2-methylpiperidin-l-yl, 2- (pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl, (2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl, 2-isobutylpyrrolidin-l-yl, 2-ethylpyrrolidin-l-yl, (4aR, 8aS)-octahydroisoquinolin- 2(lH)-yl, 1-azepanyl, or 2,6-dimethylpiperidin-l-yl.
32. A compound according to any preceding claim wherein -NRl -^aRl 3b 1S 2- methylpyrrolidin- 1 -yl.
33. A compound of formula (I) according to any preceding claim wherein -NR*5R16 is selected from the group consisting of -piperidinyl, 2-methylpyrrolidin-l-yl, 1- pyrrolidinyl, 1-azepanyl, 2-methylpiperidin-l-yl, (3,5-dimethyl)piperidin-l-yl, hexyl(methyl)amino, benzyl(methyl)amino, 2-azaspiro[5.5]undec-2-yl, 7,8-dimethyl- lazaspiro[4.4]non-l-yl, 2-oxopyrrolidin-l-yl, anilino, 2-methyl-lH-imidazol-l-yl, IH- 1,2,4-triazol-l-yl, [l-(hydroxymethyl)-3-methylbutyl]amino, cyclopentylamino, (1,3- dimethylbutyl)amino, (cyclopropylmethyl)(propyl)amino, 2,6-dimethylpiperidin- 1 -yl, (2-furylmethyl)(methyl)amino, sec-butyl(propyl)amin, 4-benzylpiperidin-l-yl, 4- cyclopentylpiperazin-1-yl, 4-moφholinyl, (4-fluorobenzyl)amino, (4- chlorobenzyl)amino, 2-oxopiperidin-l-yl, (5S)-2-oxo-5-pyrrolidin-l-yl, (4- fluorophenyl)amino, (4aR,8aS)-octahydroisoquinolin-2(lH)-yl, (2S)-2-(pyrrolidin-l- ylmethyl)pyrrolidin-l-yl, (3-methoxyphenyl)amino, (pyridin-3-yl)amino, benzylamino and 4,4-difluoropiperidin-l-yl.
34. A compound of formula (I) according to any preceding claim wherein -NR15R16 is 1- piperidinyl, 1-pyrrolidinyl, 2-methylpyrrolidin-l-yl, 7,8-dimethyl-lazaspiro[4.4]non-l- yl, lH-l,2,4-triazol-l-yl, [l-(hydroxymethyl)-3-methylbutyl]amino, 2,6- dimethylpiperidin-l-yl, benzylamino, sec-butyl(propyl)amino, (4aR, 8aS)- octahydroisoquinolin-2(l H)-yl and (2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl.
35. A compound of formula (I) according to any preceding claim wherein -NR15R16 1S I_ piperidinyl.
36. A compound of formula (T) according to any preceding claim wherein -NR17R18 is 4- morpholinyl or 4,4-difluoropiperidin- 1 -yl.
37. A compound according to any preceding claim wherein m is equal to 3 or 4.
38. A compound according to any preceding claim wherein m is equal to 3.
39. A compound according to any preceding claim wherein w is equal to 1.
40. A compound of formula (I) according to claim 1 selected from the group consisting of l-(3-{4-[4-(piperidin-l-ylmethyl)-l,3-oxazol-2-yl]phenoxy}propyl)piperidine; 1 -[3 -(4- {4- [(2-methylpyrrolidin- 1 -yl)methyl] - 1 ,3-oxazol-2- yl}phenoxy)propyl]piperidine;
1 -(3 - {4- [4-(pyrrolidin- 1 -ylmethyl)- 1 ,3 -oxazol-2-yl]phenoxy }propyl)piperidine;
1 -( {2- [4-(3 -piperidin- 1 -ylpropoxy)phenyl]- 1 ,3 -oxazol-4-yl} methyl)azepane;
4-methyl-l-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3-oxazol-4- yl}methyl)piperidine;
2-methyl- 1 -( {2- [4-(3 -piperidin- 1 -ylpropoxy)phenyl]- 1 ,3 -oxazol-4- yl } methyl)piperidine ;
3 , 5-dimethyl- 1 -( {2-[4-(3 -piperidin- 1 -ylpropoxy)phenyl] - 1 ,3 -oxazol-4- yl}methyl)piperidine; N-hexyl-N-methyl-N-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3-oxazol-4- yl } methyl)amine;
N-benzyl-N-methyl-N-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3-oxazol-4- yl } methyl)amine ;
4-(pyrrolidin- 1 -ylmethyl)-2-[4-(3 -pyrrolidin- 1 -ylpropoxy)phenyl] -1,3 -oxazole; N-[(2-{4-[3-(4-isopropylpiperazin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)methyl]-
N-methylhexan- 1 -amine;
N-(2-methoxy- 1 -methylethyl)-N-( {2-[4-(3-piperidin- 1 -ylpropoxy)phenyl]- 1,3- oxazol-4-yl}methyl)amine; 2-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)methyl]-2- azaspiro[5.5 ]undecane;
7,8-dimethyl- 1 -( {2-[4-(3-piperidin- 1 -ylpropoxy)phenyl]- 1 ,3-oxazol-4-yl} methyl)- 1 - azaspiro[4.4]nonane; 4-[(2-methylpyrrolidin-l-yl)methyl]-2-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl } - 1 , 3 -oxazole ;
1 -isopropyl-4-(3- {4-[4-(pyrrolidin- 1 -ylmethyl)- 1 ,3-oxazol-2- yl]phenoxy}propyl)piperazine;
1 -isopropyl-4-[3-(4- {4-[(2-methylpiperidin- 1 -yl)methyl]- 1 ,3 -oxazol-2- yl}phenoxy)propyl]piperazine;
4-methyl-l-[3-(4-{4-[(2-methylρyrrolidin-l-yl)methyl]-l,3-oxazol-2- yl }phenoxy)propyl]piperidine;
2-methyl- 1 -[3-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)propyl]piperidine; 4-[(2-methylpyrrolidin- 1 -yl)methyl]-2-(4- {3-[2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 - yl]propoxy } phenyl)- 1 , 3 -oxazole;
1 -cyclopentyl-4- [3 -(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- J ,3 -oxazol-2- yl}phenoxy)propyl]piperazine;
N,N-dimethyl- 1 -[4-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)butyl]pyrrolidin-3-amine; l-[2-(4-{4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazol-2-yl}phenoxy)ethyl]-4-(2- pyrrolidin- 1 -ylethyl)piperazine;
2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-4-(2-oxo-2-pyrrolidin-l- ylethyl)- 1 ,3 -oxazole; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]pyrrolidin-2-one;
N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4-yl)methyl]-N- phenylamine;
2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } -4-(2-pyrrolidin- 1 -ylethyl)- 1,3- oxazole;
4-[(2-methyl-lH-imidazol-l-yl)methyl]-2-{4-[3-(2-methylρyrrolidin-l- yl)propoxy]phenyl} -1,3 -oxazole; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)methyl]-lH- 1,2,4-triazole; 4-(pyrrolidin-l-ylmethyl)-2-[3-(3-pyrrolidin-l-ylpropoxy)phenyl]-l,3-oxazole;
1 - [(2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 -oxazol-4- yl)methyl]piperidine;
1 -[3-(4- {4-[(2-methylpyrrolidin-l -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)propyl]azepane; l-(3-{4-[4-methyl-5-(piperidin-l-ylmethyl)-l,3-oxazol-2- yl]phenoxy}propyl)piperidine;
(2R)-4-methyl-2- { [(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol- 4-yl)methyl]amino}pentan- 1 -ol; N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]cyclopentanamine;
1 -[4-(4- {4-[(2-methylρyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)butyl]azepane; l-[2-(4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl}phenoxy)ethyl]azepane;
N-(l,3-dimethylbutyl)-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3- oxazol-4-yl)methyl]amine;
N-(cyclopropylmethyl)-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]plienyl}-l,3- oxazol-4-yl)methyl]-N-propylamine; l-[3-(4-{4-[(2,6-dimethylpiperidin-l-yl)methyl]-l,3-oxazol-2-yl}phenoxy)propyl]-
2,6-dimethylpiperidine;
1 -( {2-[4-(2-piperidin- 1 -ylethoxy)phenyl]- 1 ,3-oxazol-4-yl} methyl)piperidine; l-[(2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; 2-methyl- 1 -[4-(4- {4- [(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2- yl }phenoxy)butyl]piperidine;
1 -(3 - {4- [4-(piperidin- 1 -ylmethyl)- 1 ,3 -thiazol-2-yl]phenoxy}propyl)piperidine;
4-(pyrrolidin- 1 -ylmethyl)-2- [4-(3 -pyrrolidin- 1 -ylpropoxy)phenyl]- 1 ,3 -thiazole;
7,8-dimethyl-l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazol-4- yl)methyl]- 1 -azaspiro[4.4]nonane;
N-(2-furylmethyl)-N-methyl-N-[(2-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl}-l,3-thiazol-4-yl)methyl]amine;
N-(sec-butyl)-N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-tbiazol-4- yl)methyl]-N-propylamine; 1 -(3- {4-[4-(pyrrolidin- 1 -ylmethyl)- 1 ,3 -thiazol-2-yl]phenoxy}propyl)piperidine; l-({2-[4-(3-piperidin-l-ylpropoxy)phenyl]-l,3-thiazol-4-yl}methyl)azepane; 1 -[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-thiazol-4- yl)methyl]piperidine; 1 -[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)acetyl]piperidine;
1 -(3- {4-[4-(2-oxo-2-piperidin- 1 -ylethyl)- 1 ,3-oxazol-2-yl]phenoxy}propyl)piperidine; l-[2-(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)ethyl]piperidine; 2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3-thiazole;
4-benzyl-l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine;
1 -cyclopentyl-4-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperazine; 1 - { [2-(4- {3-[(2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 -yl]propoxy }phenyl)- 1,3- oxazol-4-yl]methyl}piperidine;
1 -(3- {4- [5-methyl-4-(piperidin- 1 -ylmethyl)- 1 ,3 -oxazol-2- yl]phenoxy}propyl)piperidine;
1 -(3- {2-fluoro-4-[4-(piperidin- 1 -ylmethyl)- 1 ,3-oxazol-2-yl]phenoxy}propyl)piperidine; l-(3-{2,6-dimethyl-4-[4-(piperidin-l-ylmethyl)-l,3-oxazol-2- yl]phenoxy}propyl)piperidine;
4-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)carbonyl]morpholine;
1 -cyclopentyl-4-( {2- [4-(3 -piperidin- 1 -ylpropoxy)phenyl] - 1 ,3-oxazol-4- yl}carbonyl)piperazine;
1 -[(2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)carbonyl]piperidine; l-cyclopentyl-4-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)carbonyl]piperazine; 4-[(2-methylpyrrolidin-l-yl)methyl]-2-(4-{3-[(2S)-2-(pyrrolidin-l-yhnethyl)pyrrolidin- l-yl]propoxy}phenyl)-l,3-oxazole; l-[(2-{3-fluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; l-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-5- yl)carbonyl]piperidine;
N-(cyclopropylmethyl)-4-methyl-2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -
N-propyl-l,3-oxazole-5-carboxamide; N-cyclopentyl-4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1,3- oxazole-5 -carboxamide; methyl 4-[(benzylamino)methyl]-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -
1 ,3-oxazole-5-carboxylate; methyl 4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazole-5- carboxylate;
2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } -4-(piperidin- 1 -ylmethyl)- 1,3- oxazole-5-carboxylic acid;
N-(cyclopropyhnethyl)-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -N-propyl- l,3-oxazole-4-carboxamide; N-cyclopentyl-2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 -oxazole-4- carboxamide;
N-(4-fluorobenzyl)-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3- oxazole-4- carboxamide;
N-benzyl-4-methyl-2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 -oxazole-5 - carboxamide;
1 -cyclopentyl-4- [(4-methyl-2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 - oxazol-5-yl)carbonyl]piperazine;
2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -4-(pyrrolidin- 1 -ylcarbonyl)- 1,3- oxazole; 4-[(4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3-oxazol-5- yl)carbonyl]moφholine;
4-{[4-methyl-2-(4-{3-[(2R)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3-oxazol-5- yl]carbonyl} morpholine;
4-{[4-methyl-2-(4-{3-[(2S)-2-methylpyrrolidin-l-yl]propoxy}phenyl)-l,3-oxazol-5- yl]carbonyl} morpholine;
1 -cyclopentyl-4- [(4-methyl-2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 - oxazol-5-yl)methyl]piperazine;
N-(cyclopropyhnethyl)-N-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l- yl)propoxy]phenyl } - 1 ,3 -oxazol-5-yl)methyl] -N-propylamine; N-benzyl-N-[(4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-
5-yl)methyl]amine; l-[(2-{3-methoxy-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine; N-(4-chlorobenzyl)-N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3-oxazol-
4-yl)methyl] amine;
N-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-5- yl)methyl]cyclopentanamine;
1 -[(5-bromo-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine;
1 - { [2-(4- {3-[(2R)-2-methylpyrrolidin- 1 -yl]ρropoxy}phenyl)- 1 ,3-oxazol-4- yl]methyl}piperidine;
1 - { [2-(4- {3-[(2S)-2-methylpyrrolidin- 1 -yl]propoxy}phenyl)- 1 ,3-oxazol-4- yl]methyl}piperidine; 4-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]morpholine;
1 -[2-(2- {4-[2-(2-methylpyrrolidin- 1 - yl)ethoxy]phenyl} - 1 ,3-oxazol-4- yl)ethyl]piperidine; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidin-2-one;
(5S)-I -[(2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy]phenyl} - 1 ,3-oxazol-4-yl)methyl]-5-
(pyrrolidin- 1 -ylmethyl)pyrrolidm-2-one;
1 -[(2- {3-chloro-4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine; l-[(2- {4-[3-(2-isobutylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine; methyl 2- {3-bromo-4-[3-(2-methylpyrrolidin- l-yl)propoxy]phenyl} -4-methyl- 1 ,3- thiazole-5-carboxylate;
1 -(3- {4-[4-methyl-5-(2-oxo-2-piperidin- 1 -ylethyl)- 1 ,3-thiazol-2- yl]phenoxy}propyl)piperidine;
N-(4-fluorophenyl)-2-(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-
4-yl)acetamide; l-[(2- {4-[3-(2-ethylpyrrolidin- 1 -yl)propoxy]phenyl}-l ,3-oxazol-4- yl)methyl]piperidine; (4aR,8aS)-2-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]decahydroisoquinoline;
2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } -4- { [(2S)-2-(pyrrolidin- 1 - ylmethyl)pyrrolidin-l-yl]carbonyl}-l,3-oxazole; 4-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)acetyl]moφholine;
N-cyclopentyl-2-(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3 -oxazol-4- yl)acetamide;
N-(cyclopropylmethyl)-2-(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1,3- oxazol-4-yl)-N-propylacetamide; l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)proρoxy]phenyl}-l,3-oxazol-4-yl)acetyl]azepane; l-(3- {4-[4-methyl-5-(2-piperidin- 1 -ylethyl)- 1 ,3-thiazol-2- yl]phenoxy}propyl)piperidine;
(5S)-l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4-yl)methyl]-5- (morpholin-4-ylmethyl)pyrrolidin-2-one;
(4aS,8aR)-2-(3-{4-[4-(piperidin-l-ylmethyl)-l,3-oxazol-2- yl]phenoxy}propyl)decahydroisoquinoline;
2-methyl-N-[(2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]-2H-tetraazol-5-amine; N-(3-methoxyphenyl)-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3- oxazol-4-yl)methyl]amine;
N-(4-fluorophenyl)-N-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-
4-yl)methyl]amine;
N-[(2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3-oxazol-4-yl)methyl]pyridin- 3 -amine;
4-[(4-methyl-2- {4-[3-(2-methylpyrrolidin-l -yl)propoxy]phenyl} - 1 ,3-oxazol-5- yl)methyl]morpholine;
4-({(2S)-l-[(2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]ρhenyl}-l,3-oxazol-4- yl)methyl]pyrrolidin-2-yl}methyl)moφholine; l-[(2-{2-fluoro-4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-oxazol-4- yl)methyl]piperidine;
4,4-difluoro-l-[(2- {4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-oxazol-4- yl)methyl]piperidine; 4-[(4-methyl-2-{6-[3-(2-methylpyrrolidin-l-yl)propoxy]pyridin-3-yl}-l,3-thiazol-5- yl)carbonyl]morpholine;
1 -[(2- {3 ,5 -difluoro-4- [3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl } - 1 ,3 -oxazol-4- yl)methyl]piperidine; 4,4-difluoro-l -[(4-methyl-2- {4-[3-(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} -1 ,3- thiazol-5-yl)carbonyl]piperidine;
4,4-difluoro- 1 - { [4-methyl-2-(4- {3 - [(2R)-2-methylpyrrolidin- 1 -yl]propoxy } phenyl)- 1 ,3 - thiazol-5-yl]carbonyl}piperidine;
4,4-difluoro- 1 - {[4-methyl-2-(4- {3-[(2S)-2-methylρyrrolidin- l-yl]propoxy}phenyl)- 1 ,3- thiazol-5-yl]carbonyl}piperidine;
4-[(4-methyl-2- {4-[3 -(2-methylpyrrolidin- 1 -yl)propoxy]phenyl} - 1 ,3-thiazol-5- yl)carbonyl]morpholine;
4- { [4-methyl-2-(4- {3-[(2R)-2-methylpyrrolidin- 1 -yl]propoxy}phenyl)- 1 ,3-thiazol-5- yl]carbonyl}moφholine; 4-{[4-methyl-2-(4-{3-[(2S)-2-methylpyrrolidin-l-yl]ρropoxy}ρhenyl)-l,3-thiazol-5- yl]carbonyl}moφholine;
1 -[(2- {2-methyl-4- [3 -(2-methylpyrrolidin- 1 -yi)propoxy]phenyl } - 1 ,3 -oxazol-4- yl)methyl]piperidine; and l-[(4-methyl-2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-l,3-thiazol-5- yl)methyl]pyrrolidin-2-one.
41. A compound of formula (I) according to any preceding claim for use as a medicament.
42. A pharmaceutical composition comprising an effective amount of a compound of formula (I) according to any preceding claim, or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable diluent or carrier.
43. Use of a compound of formula (I) according to any preceeding claims or of a pharmaceutical composition according to claim 42 for the manufacture of a medicament for the treatment and prevention of mild-cognitive impairement, Alzheimer's disease, learning and memory disorders, attention-deficit hyperactivity disorder, Parkinson's disease, schizophrenia, dementia, depression, epilepsy, seizures, convulsions, sleep/wake disorders, cognitive dysfunctions, narcolepsy, hypersomnia, obesity, upper airway allergic disorders, Down's syndrome, anxiety, stress, cardiovascular disorders, inflammation and pain.
44. A synthetic intermediate of formula (XIII) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000184_0001
(XIH)
wherein
A1 is CH, C(CH3) or C-halogen;-
A3 is O or S;
Q is hydrogen, COOR', -(C=O)1-NR15R16 or halogen; R' is hydrogen or C 1.4 alkyl; R1 is hydrogen, halogen or C \ .4 alkyl;
R3 is hydrogen;
R4' is hydrogen, halogen, C \ .4 alkyl, C 1.4 alkoxy or -O-(CH2)n-Cl.
R5' is hydrogen, hydroxy, -O-(CH2)m-halogen, -O-CH2-Phenyl, or -O-(CH2)m-
NR13aR13b; R11 is hydrogen, C \ .4 alkyl, halogen or -(CH2V(C=O)2-NR17R18;
R13a and R13^ are linked together to form a C^-β alkylene, each methylene of the alkylene being optionally substituted by one or two C^ .4 alkyl, an amino group or C\.β alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Cj.g alkyl, C3..6 cycloalkyl or C\.§ alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C3.6 alkylene.
R15 is hydrogen or a C^.g alkyl; R.16 is aryl, heteroaryl, Cj.g alkyl, C\.β alkyl cycloalkyl, C^s cycloalkyl, C\.β alkyl aryl or a CH2- heteroaryl; or R!5 and Rl 6 are linked together to form a C^.β alkylene, each methylene of the alkylene being optionally substituted by one or two C \ .4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by C \ _g alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C^.g alkyl or C3_g cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3_g cycloalkyl or a carbonyl and another methylene being optionally substituted by an alkylamine; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C3.6 alkylene; or R^ and Rl 6 are linked together to form with N an unsaturated 5- or 6-membered heteroaryl optionally substituted by a C^ .4 alkyl; R!7 is hydrogen or a Cj_g alkyl;
R!8 is Cj_8 alkyl, C1-6 alkyl cycloalkyl or C\.β alkyl aryl; or R!7 and R^ are linked together to form a C3..6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a Cj.3 alkyl or C3..6 cycloalkyl; w is an integer equal to 0 or 1 ; t is an integer equal to 0 or 1; z is an integer equal to 0 or 1 ; and m is an integer equal to 2, 3 or 4; and provided that when R5' is O-CH2-Phenyl, R4' is halogen; and that compound (XIII) is different from 4-(2-oxazolylphenol), 4-(4-chloromethyl- oxazol-2-yl)phenol; 4-(4-chloromethyl-thiazol-2-yl)phenol, ethyl 2-(4- hydroxyphenyl)oxazole-4-carboxylate, 2-(4-hydroxy-phenyl)-4-[2-(methoxycarbonyl)~ ethyl]-l,3-thiazole; 4-(5-ethyl-2-thiazolyl)phenol and 4-(4-methyl-oxazol-2-yl)phenol.
45. A synthetic intermediate of formula (XHIbis) geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof,
Figure imgf000186_0001
wherein A1 is CH or N; A3 is O or S;
Q' is hydrogen, COOR', halogen or -(C=O)2-NRl 7R18; R' is hydrogen or Cj .4 alkyl;
R1 is hydrogen; R3 is hydrogen; R4' is hydrogen;
R5 ' is hydrogen, halogen, -O-(CH2)m-halogen or -0-(CH2)U1-NR13aRl 3b; R10 is Ci_4 alkyl or -(C=O)1-NR15R16;
R13a and R13^ are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C 1.4 alkyl, an amino group or C\.β alkyl amino, one methylene being optionally replaced by a nitrogen atom, said nitrogen atom being optionally substituted by a Cj _ g alkyl, C3.6 cycloalkyl or C1-6 alkyl amino; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C3.6 alkylene.
R15 is hydrogen or a Cj.g alkyl; R16 is aryl, a heteroaryl, Cj.g alkyl, C3..6 cycloalkyl, C\_β alkyl cycloalkyl, C\.β alkyl aryl or a CH2- heteroaryl; or R15 and R16 are linked together to form a C3.6 alkylene, each methylene of the alkylene being optionally substituted by one or two C\ .4 alkyl or by one or two halogen; or one methylene of the alkylene being optionally substituted by an alkylamine or by C\.β alkyl aryl; one methylene of the alkylene being optionally replaced by a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C\_ g alkyl or C3.6 cycloalkyl; or one methylene of the alkylene being optionally replaced by a C3_g cycloalkyl or a carbonyl and another methylene being optionally substituted by an alkylamine; or one methylene of the alkylene being linked with a second methylene of the alkylene to form a C^-β alkylene; or Tl)-S and R.16 are linked together to form with N an unsaturated 5- or 6-membered heteroaryl optionally substituted by a Cj .4 alkyl; R.17 is hydrogen or a Cj.g alkyl;
Rl 8 is Ci_g alkyl, C\.β alkyl cycloalkyl or C1-6 alkyl aryl; or R!7 and R* 8 are linked together to form a C3_g alkylene, each methylene of the alkylene being optionally substituted by one or two Cj .4 alkyl or by one or two halogen, one methylene of the alkylene being optionally replaced by a carbonyl, a nitrogen atom or an oxygen atom, said nitrogen atom being optionally substituted by a C^. § alkyl or Cβ.g cycloalkyl; t is an integer equal to 0 or 1; m is an integer equal to 2, 3 or 4; z is an integer equal to 0 or 1; and r is an integer equal to 0 or 1.
46. A synthetic intermediate which is selected from the group consisting of
4-(4-chlorobutoxy)benzamide;
3 -(3 -chloropropoxy)benzamide; 4-(3-chloropropoxy)benzenecarbothioamide;
4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole;
2-[4-(2-chloroethoxy)phenyl]-4-(chloromethyl)- 1 ,3-oxazole;
2- [4-(4-chlorobutoxy)phenyl] -4-(chloromethyl)- 1 ,3-oxazole; methyl {2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}acetate; {2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}acetic acid;
2-[4-(3-chloropropoxy)phenyl]-4-(2-oxo-2-pyrrolidin-l-ylethyl)-l,3-oxazole;
4- {4-[(2-methylpyrrolidin- 1 -yl)methyl]- 1 ,3-oxazol-2-yl}phenol;
2-[4-(3-chloropropoxy)phenyl]-4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazole;
2-[4-(2-chloroethoxy)phenyl]-4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazole; 2-[4-(4-chlorobutoxy)phenyl]-4-[(2-methylpyrrolidin-l-yl)methyl]-l,3-oxazole;
4-(chloromethyl)-2-[3 -(3 -chloropropoxy)phenyl] -1,3 -oxazole;
4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-thiazole;
{2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazol-5-yl}methanol; methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5-carboxylate; l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}acetyl)piperidine;
2-{2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}-N-(4-fluorophenyl)acetamide;
4-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}acetyl)morpholine;
2-{2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}-N-cyclopentylacetamide; 2-{2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}-N-(cyclopropylmethyl)-N- propylacetamide; l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}acetyl)azepane;
2-[4-(3-chloropropoxy)phenyl]-4,5-dimethyl- 1 ,3-oxazole;
4-(bromomethyl)-2-[4-(3-chloropropoxy)phenyl]-5-methyl-l,3-oxazole; 4-(bromomethyl)-2-[4-(3-bromopropoxy)phenyl]-5-methyl- 1 ,3-oxazole; ethyl 2-[4-(3-chloropropoxy)phenyl]- 1 ,3-oxazole-4-carboxylate;
2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-4-carboxylic acid;
4-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}carbonyl)morpholine; l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}carbonyl)piperidine; 1 -( {2-[4-(3-chloropropoxy)phenyl]- 1 ,3 -oxazol-4-yl} carbonyl)-4- cyclopentylpiperazine;
2-[4-(3-chloropropoxy)phenyl]-N-(cyclopropylmethyl)-N-propyl-l,3-oxazole-4- carboxamide;
2-[4-(3-chloropropoxy)phenyl]-N-cyclopentyl-l,3-oxazole-4-carboxamide; 2-[4-(3-chloropropoxy)phenyl]-N-(4-fluorobenzyl)- 1 ,3-oxazole-4-carboxamide;
2-[4-(3-chloropropoxy)phenyl]-4-(pyrrolidin-l-ylcarbonyl)-l,3-oxazole;
2- [4-(3 -chloropropoxy)phenyl] -4- { [(2S)-2-(pyrrolidin- 1 -ylmethyl)pyrrolidin- 1 - yl]carbonyl} - 1 ,3-oxazole;
2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5-carboxylic acid; 2-[4-(3-chloropropoxy)phenyl]-N-(cyclopropylmethyl)-4-methyl-N-propyl-l,3- oxazole-5-carboxamide; l-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazol-5-yl}carbonyl)piperidine;
1 -( {2-[4-(3-chloropropoxy)phenyl]-4-methyl- 1 ,3-oxazol-5-yl} carbonyl)-4- cyclopentylpiperazine; N-benzyl-2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazole-5-carboxamide;
4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-oxazol-5-yl}carbonyl)morpholine;
2-[4-(3-chloropropoxy)phenyl]-N-cyclopentyl-4-methyl-l,3-oxazole-5- carboxamide; methyl [2-(4-hydroxyphenyl)-l,3-oxazol-4-yl]acetate; methyl {2-[4-(2-chloroethoxy)phenyl]-l,3-oxazol-4-yl}acetate; methyl (2- {4-[2-(2-methylpyrrolidin- 1 -yl)ethoxy]phenyl} - 1 ,3-oxazol-4-yl)acetate;
(2- {4-[2-(2-methylpyrrolidin- 1 -yl)ethoxy]phenyl} - 1 ,3-oxazol-4-yl)acetic acid; l-[(2-{4-[2-(2-methylpyrrolidin-l-yl)ethoxy]phenyl}-l,3-oxazol-4- yl)acetyl]piperidine; l-( {2-[4-(3-chloropropoxy)phenyl]- 1 ,3-oxazol-4-yl}methyl)piperidin-2-one;
(5S)-I -( {2-[4-(3-chloropropoxy)phenyl]- 1 ,3 -oxazol-4-yl} methyl)-5-(pyrrolidin- 1 - ylmethyl)pyrrolidin-2-one;
(5S)-l-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)-5-(morpholin-4- ylmethyl)pyrrolidin-2-one;
1 -( {2-[4-(3-chloropropoxy)phenyl]- 1 ,3 -oxazol-4-yl} methyl)pyrrolidin-2-one;
(2-chloro- 1 ,3 -oxazol-4-yl)methyl methanesulfonate;
1 - [(2-chloro- 1 ,3 -oxazol-4-yl)methyl]piperidine; l-({2-[4-(benzyloxy)-3-chlorophenyl]-l,3-oxazol-4-yl}methyl)piperidine; l-({2-[4-(benzyloxy)-3-fluorophenyl]-l,3-oxazol-4-yl}methyl)piperidine;
2, 6-dimethyl-4- [4-(piperidin- 1 -ylmethyl)- 1 ,3 -oxazol-2-yl]phenol;
2-methoxy-4-[4-(piperidin- 1 -ylmethyl)- 1 ,3-oxazol-2-yl]phenol;
2-chloro-4-[4-(piperidin-l -ylmethyl)- 1 ,3-oxazol-2-yl]phenol;
2-fluoro-4- [4-(piperidin- 1 -ylmethyl)- 1 ,3 -oxazol-2-yl]phenol; l-({2-[3-chloro-4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)piperidine; l-({2-[4-(3-chloropropoxy)-3,5-dimethylphenyl]-l,3-oxazol-4- yl } methyl)piperidine; l-({2-[4-(3-chloropropoxy)-3-fluorophenyl]-l,3-oxazol-4-yl}methyl)piperidine; l-({2-[4-(3-chloropropoxy)-3-methoxyphenyl]-l,3-oxazol-4-yl}methyl)piperidine; 3-chloropropyl 4-(3-chloropropoxy)-2-fluorobenzoate;
3-chloropropyl 4-(3-chloropropoxy)-2-methylbenzoate;
3-chloroproρyl 4-(3-chloropropoxy)-3,5-difluorobenzoate;
4-(3-chloropropoxy)-2-fluorobenzoic acid;
4-(3-chloropropoxy)-2-methylbenzoic acid; 4-(3-chloropropoxy)-3,5-difluorobenzoic acid;
4-(3-chloropropoxy)-2-fluorobenzoyl chloride;
4-(3 -chloropropoxy)-2-methylbenzoyl chloride;
4-(3-chloropropoxy)-3,5-difluorobenzoyl chloride;
4-(3-chloropropoxy)-2-fluorobenzamide; 4-(3-chloropropoxy)-2-methylbenzamide;
4-(3-cUoropropoxy)-3,5-difluorobenzamide;
4-(chloromethyl)-2-[4-(3-chloropropoxy)-2-fluorophenyl]-l,3-oxazole;
4-(chloromethyl)-2- [4-(3 -chloropropoxy)-2-methylphenyl] - 1 ,3 -oxazole; 4-(chloromethyl)-2-[4-(3-chloropropoxy)-3,5-difluorophenyl]- 1 ,3-oxazole; l-({2-[4-(3-chloropropoxy)-2-fluorophenyl]-l,3-oxazol-4-yl}methyl)piperidine;
1 -( {2-[4-(3 -chloropropoxy)-2-methylphenyl] -1,3 -oxazol-4-yl } methyl)piperidine;
1 -( {2-[4-(3-chloropropoxy)-3,5-difluorophenyl]- 1 ,3-oxazol-4-yl}methyl)piperidine;
2-[4-(3-chloropropoxy)phenyl]-l,3-thiazole; 5-bromo-4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole; l-({5-bromo-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)piperidine; methyl 2-[3-bromo-4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5- carboxylate; methyl 4-(bromomethyl)-2-[4-(3-chloropropoxy)phenyl]- 1 ,3-oxazole-5-carboxylate; ethyl 4-(bromomethyl)-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-5-carboxylate; methyl 4-[(benzylamino)methyl]-2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-5- carboxylate; ethyl 2-[4-(3-chloropropoxy)phenyl]-4-(piperidin-l-ylmethyl)-l,3-oxazole-5- carboxylate; ethyl 2-{4-[3-(2-methylpyrrolidin-l-yl)propoxy]phenyl}-4-(piperidin-l-ylmethyl)-
1 ,3-oxazole-5-carboxylate; ethyl 2-(6-chloropyridin-3-yl)-4-methyl- 1 ,3-thiazole-5-carboxylate;
2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazole-5-carboxylic acid;
4-{[2-(6-chloropyridin-3-yl)-4-methyl-l,3-thiazol-5-yl]carbonyl}moφholine; 2-[4-(3-chloropropoxy)phenyl]-l,3-oxazole-4-carbaldehyde;
N-({2-[4-(3-chloropropoxy)phenyl]-l,3-oxazol-4-yl}methyl)-2-methyl-2H-tetrazol- 5-amine; ethyl {2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}acetate;
{2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}acetic acid; l-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}acetyl)piperidine; methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5-carboxylate;
2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazole-5-carboxylic acid;
4-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}carbonyl)morpholine; l-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}carbonyl)-4,4- difluoropiperidine;
{2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}methanol; and l-({2-[4-(3-chloropropoxy)phenyl]-4-methyl-l,3-thiazol-5-yl}metliyl)pyrrolidin-2- one.
47. Use of a synthetic intermediate according to any one of claims 44, 45 and 46 for the preparation of compound of formula (I).
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US7790720B2 (en) 2010-09-07
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JP2008534542A (en) 2008-08-28
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