WO2006099604A3 - Methods and compositions for assay readouts on multiple analytical platforms - Google Patents
Methods and compositions for assay readouts on multiple analytical platforms Download PDFInfo
- Publication number
- WO2006099604A3 WO2006099604A3 PCT/US2006/009898 US2006009898W WO2006099604A3 WO 2006099604 A3 WO2006099604 A3 WO 2006099604A3 US 2006009898 W US2006009898 W US 2006009898W WO 2006099604 A3 WO2006099604 A3 WO 2006099604A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compositions
- tags
- methods
- labeling
- oligonucleotide tags
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention provides methods and compositions for reading out the results of multiplex assays on various analytical platforms, such as microarrays, bead arrays, electrophoresis devices, and the like. An important feature of the invention includes methods for converting different sets of oligonucleotide tags used for labeling into oligonucleotide tags specific for a particular analytical platform. The invention further includes compositions comprising oligonucleotide tags having convenient properties for labeling and conversion, particularly ligation tags that employ ligation reaction specificity as well as sequence specificity in order to discriminate between tags.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06738889A EP1856293A2 (en) | 2005-03-16 | 2006-03-16 | Methods and compositions for assay readouts on multiple analytical platforms |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66216705P | 2005-03-16 | 2005-03-16 | |
US60/662,167 | 2005-03-16 | ||
US73885205P | 2005-11-21 | 2005-11-21 | |
US60/738,852 | 2005-11-21 | ||
US74048005P | 2005-11-29 | 2005-11-29 | |
US60/740,480 | 2005-11-29 | ||
US77509806P | 2006-02-21 | 2006-02-21 | |
US60/775,098 | 2006-02-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006099604A2 WO2006099604A2 (en) | 2006-09-21 |
WO2006099604A3 true WO2006099604A3 (en) | 2009-04-23 |
Family
ID=36992470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/009898 WO2006099604A2 (en) | 2005-03-16 | 2006-03-16 | Methods and compositions for assay readouts on multiple analytical platforms |
Country Status (3)
Country | Link |
---|---|
US (1) | US20060211030A1 (en) |
EP (1) | EP1856293A2 (en) |
WO (1) | WO2006099604A2 (en) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
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US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
EP2387627B1 (en) | 2009-01-15 | 2016-03-30 | Adaptive Biotechnologies Corporation | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
EP2396459B1 (en) | 2009-02-13 | 2017-05-03 | X-Chem, Inc. | Methods of creating and screening dna-encoded libraries |
EP3409792B1 (en) | 2009-06-25 | 2023-09-20 | Fred Hutchinson Cancer Center | Method of measuring adaptive immunity |
US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
PT2623613T (en) | 2010-09-21 | 2016-10-11 | Population Genetics Tech Ltd | Increasing confidence of allele calls with molecular counting |
KR102242879B1 (en) | 2011-09-07 | 2021-04-20 | 엑스-켐, 인크. | Methods for tagging dna-encoded libraries |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
US9279159B2 (en) | 2011-10-21 | 2016-03-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
CA2858070C (en) | 2011-12-09 | 2018-07-10 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
JP6375230B2 (en) | 2012-02-27 | 2018-08-15 | セルラー リサーチ, インコーポレイテッド | Compositions and kits for molecular counting |
WO2013130512A2 (en) | 2012-02-27 | 2013-09-06 | The University Of North Carolina At Chapel Hill | Methods and uses for molecular tags |
WO2013128281A1 (en) | 2012-02-28 | 2013-09-06 | Population Genetics Technologies Ltd | Method for attaching a counter sequence to a nucleic acid sample |
WO2013134162A2 (en) | 2012-03-05 | 2013-09-12 | Sequenta, Inc. | Determining paired immune receptor chains from frequency matched subunits |
CN104520440B (en) | 2012-05-08 | 2017-10-03 | 适应生物技术公司 | Composition and method for measuring and calibrating the amplification bias in multi-PRC reaction |
ES2855137T3 (en) | 2012-07-13 | 2021-09-23 | X Chem Inc | DNA-encoded libraries that have coding oligonucleotide linkages that cannot be read by polymerases |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
IL305303A (en) | 2012-09-04 | 2023-10-01 | Guardant Health Inc | Systems and methods to detect rare mutations and copy number variation |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
JP6449160B2 (en) | 2012-10-01 | 2019-01-09 | アダプティブ バイオテクノロジーズ コーポレイション | Cross-reference of applications related to immune competence assessment by adaptive immune receptor diversity and clonal characterization |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
KR20230074639A (en) | 2013-08-28 | 2023-05-30 | 벡톤 디킨슨 앤드 컴퍼니 | Massively parallel single cell analysis |
JP2017504307A (en) | 2013-10-07 | 2017-02-09 | セルラー リサーチ, インコーポレイテッド | Method and system for digitally counting features on an array |
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US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
EP3132059B1 (en) | 2014-04-17 | 2020-01-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
AU2015339191A1 (en) | 2014-10-29 | 2017-05-18 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
WO2016086029A1 (en) | 2014-11-25 | 2016-06-02 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
ES2824700T3 (en) | 2015-02-19 | 2021-05-13 | Becton Dickinson Co | High-throughput single-cell analysis combining proteomic and genomic information |
WO2016138122A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
CN107208158B (en) | 2015-02-27 | 2022-01-28 | 贝克顿迪金森公司 | Spatially addressable molecular barcode |
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EP3277294B1 (en) | 2015-04-01 | 2024-05-15 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
WO2016172373A1 (en) | 2015-04-23 | 2016-10-27 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
WO2016196229A1 (en) | 2015-06-01 | 2016-12-08 | Cellular Research, Inc. | Methods for rna quantification |
JP6940484B2 (en) | 2015-09-11 | 2021-09-29 | セルラー リサーチ, インコーポレイテッド | Methods and compositions for library normalization |
CN108603228B (en) | 2015-12-17 | 2023-09-01 | 夸登特健康公司 | Method for determining tumor gene copy number by analyzing cell-free DNA |
WO2017192387A1 (en) | 2016-05-02 | 2017-11-09 | Cellular Research, Inc. | Accurate molecular barcoding |
JP7036438B2 (en) * | 2016-05-06 | 2022-03-15 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | Analytical standards and how to use them |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
EP3465502B1 (en) | 2016-05-26 | 2024-04-10 | Becton, Dickinson and Company | Molecular label counting adjustment methods |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
KR102638006B1 (en) | 2016-09-26 | 2024-02-20 | 셀룰러 리서치, 인크. | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
CN109952612B (en) | 2016-11-08 | 2023-12-01 | 贝克顿迪金森公司 | Method for classifying expression profiles |
CN109906274B (en) | 2016-11-08 | 2023-08-25 | 贝克顿迪金森公司 | Methods for cell marker classification |
WO2018132610A1 (en) | 2017-01-13 | 2018-07-19 | Cellular Research, Inc. | Hydrophilic coating of fluidic channels |
EP3577232A1 (en) | 2017-02-01 | 2019-12-11 | Cellular Research, Inc. | Selective amplification using blocking oligonucleotides |
KR102438495B1 (en) | 2017-06-05 | 2022-09-01 | 백톤 디킨슨 앤드 컴퍼니 | Sample indexing for single cells |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
US11946095B2 (en) | 2017-12-19 | 2024-04-02 | Becton, Dickinson And Company | Particles associated with oligonucleotides |
WO2019213237A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
EP3788171B1 (en) | 2018-05-03 | 2023-04-05 | Becton, Dickinson and Company | High throughput multiomics sample analysis |
US11639517B2 (en) | 2018-10-01 | 2023-05-02 | Becton, Dickinson And Company | Determining 5′ transcript sequences |
WO2020097315A1 (en) | 2018-11-08 | 2020-05-14 | Cellular Research, Inc. | Whole transcriptome analysis of single cells using random priming |
US11492660B2 (en) | 2018-12-13 | 2022-11-08 | Becton, Dickinson And Company | Selective extension in single cell whole transcriptome analysis |
US11371076B2 (en) | 2019-01-16 | 2022-06-28 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
WO2020154247A1 (en) | 2019-01-23 | 2020-07-30 | Cellular Research, Inc. | Oligonucleotides associated with antibodies |
WO2020214642A1 (en) | 2019-04-19 | 2020-10-22 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
CN114051534A (en) | 2019-07-22 | 2022-02-15 | 贝克顿迪金森公司 | Single cell chromatin immunoprecipitation sequencing assay |
US11773436B2 (en) | 2019-11-08 | 2023-10-03 | Becton, Dickinson And Company | Using random priming to obtain full-length V(D)J information for immune repertoire sequencing |
EP4090763A1 (en) | 2020-01-13 | 2022-11-23 | Becton Dickinson and Company | Methods and compositions for quantitation of proteins and rna |
CN115605614A (en) | 2020-05-14 | 2023-01-13 | 贝克顿迪金森公司(Us) | Primers for immune repertoire profiling |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
CN116635533A (en) | 2020-11-20 | 2023-08-22 | 贝克顿迪金森公司 | Profiling of high and low expressed proteins |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999028505A1 (en) * | 1997-12-03 | 1999-06-10 | Curagen Corporation | Methods and devices for measuring differential gene expression |
US20030049616A1 (en) * | 2001-01-08 | 2003-03-13 | Sydney Brenner | Enzymatic synthesis of oligonucleotide tags |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US514625A (en) * | 1894-02-13 | Jacob | ||
US4321365A (en) * | 1977-10-19 | 1982-03-23 | Research Corporation | Oligonucleotides useful as adaptors in DNA cloning, adapted DNA molecules, and methods of preparing adaptors and adapted molecules |
US4709016A (en) * | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
US4650750A (en) * | 1982-02-01 | 1987-03-17 | Giese Roger W | Method of chemical analysis employing molecular release tag compounds |
US5242794A (en) * | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US4883750A (en) * | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US5102785A (en) * | 1987-09-28 | 1992-04-07 | E. I. Du Pont De Nemours And Company | Method of gene mapping |
US5093245A (en) * | 1988-01-26 | 1992-03-03 | Applied Biosystems | Labeling by simultaneous ligation and restriction |
US5424186A (en) * | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
WO1991011533A1 (en) * | 1990-01-26 | 1991-08-08 | E.I. Du Pont De Nemours And Company | Method for isolating primer extension products from template-directed dna polymerase reactions |
CA2036946C (en) * | 1990-04-06 | 2001-10-16 | Kenneth V. Deugau | Indexing linkers |
EP0834576B1 (en) * | 1990-12-06 | 2002-01-16 | Affymetrix, Inc. (a Delaware Corporation) | Detection of nucleic acid sequences |
US5599921A (en) * | 1991-05-08 | 1997-02-04 | Stratagene | Oligonucleotide families useful for producing primers |
US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
ATE173767T1 (en) * | 1992-04-03 | 1998-12-15 | Perkin Elmer Corp | SAMPLES COMPOSITION AND METHODS |
US5470705A (en) * | 1992-04-03 | 1995-11-28 | Applied Biosystems, Inc. | Probe composition containing a binding domain and polymer chain and methods of use |
US5981176A (en) * | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
US5503980A (en) * | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
US5652128A (en) * | 1993-01-05 | 1997-07-29 | Jarvik; Jonathan Wallace | Method for producing tagged genes, transcripts, and proteins |
US6007987A (en) * | 1993-08-23 | 1999-12-28 | The Trustees Of Boston University | Positional sequencing by hybridization |
US5552278A (en) * | 1994-04-04 | 1996-09-03 | Spectragen, Inc. | DNA sequencing by stepwise ligation and cleavage |
US5714330A (en) * | 1994-04-04 | 1998-02-03 | Lynx Therapeutics, Inc. | DNA sequencing by stepwise ligation and cleavage |
US5710000A (en) * | 1994-09-16 | 1998-01-20 | Affymetrix, Inc. | Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping |
US5604097A (en) * | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
US6013445A (en) * | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
US5695934A (en) * | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
US5846719A (en) * | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
US5776737A (en) * | 1994-12-22 | 1998-07-07 | Visible Genetics Inc. | Method and composition for internal identification of samples |
US5763175A (en) * | 1995-11-17 | 1998-06-09 | Lynx Therapeutics, Inc. | Simultaneous sequencing of tagged polynucleotides |
US6027890A (en) * | 1996-01-23 | 2000-02-22 | Rapigene, Inc. | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
US6458530B1 (en) * | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
US5935793A (en) * | 1996-09-27 | 1999-08-10 | The Chinese University Of Hong Kong | Parallel polynucleotide sequencing method using tagged primers |
US6124092A (en) * | 1996-10-04 | 2000-09-26 | The Perkin-Elmer Corporation | Multiplex polynucleotide capture methods and compositions |
US6607878B2 (en) * | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
US6376619B1 (en) * | 1998-04-13 | 2002-04-23 | 3M Innovative Properties Company | High density, miniaturized arrays and methods of manufacturing same |
NO986133D0 (en) * | 1998-12-23 | 1998-12-23 | Preben Lexow | Method of DNA Sequencing |
US6322980B1 (en) * | 1999-04-30 | 2001-11-27 | Aclara Biosciences, Inc. | Single nucleotide detection using degradation of a fluorescent sequence |
US6627400B1 (en) * | 1999-04-30 | 2003-09-30 | Aclara Biosciences, Inc. | Multiplexed measurement of membrane protein populations |
US6355431B1 (en) * | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
US20030207295A1 (en) * | 1999-04-20 | 2003-11-06 | Kevin Gunderson | Detection of nucleic acid reactions on bead arrays |
US6287778B1 (en) * | 1999-10-19 | 2001-09-11 | Affymetrix, Inc. | Allele detection using primer extension with sequence-coded identity tags |
US6221603B1 (en) * | 2000-02-04 | 2001-04-24 | Molecular Dynamics, Inc. | Rolling circle amplification assay for nucleic acid analysis |
ATE492652T1 (en) * | 2000-02-07 | 2011-01-15 | Illumina Inc | NUCLEIC ACID DETECTION METHOD WITH UNIVERSAL PRIMING |
EP1130113A1 (en) * | 2000-02-15 | 2001-09-05 | Johannes Petrus Schouten | Multiplex ligation dependent amplification assay |
US6398313B1 (en) * | 2000-04-12 | 2002-06-04 | The Polymeric Corporation | Two component composite bicycle rim |
US20030207300A1 (en) * | 2000-04-28 | 2003-11-06 | Matray Tracy J. | Multiplex analytical platform using molecular tags |
US20030096239A1 (en) * | 2000-08-25 | 2003-05-22 | Kevin Gunderson | Probes and decoder oligonucleotides |
WO2002088395A1 (en) * | 2001-04-27 | 2002-11-07 | Board Of Regents, The University Of Texas System | Method of constructing promoter libraries |
EP1506399A2 (en) * | 2001-05-21 | 2005-02-16 | Aclara BioSciences, Inc. | Methods and compositions for analyzing proteins |
US6632611B2 (en) * | 2001-07-20 | 2003-10-14 | Affymetrix, Inc. | Method of target enrichment and amplification |
JP4663988B2 (en) * | 2002-04-12 | 2011-04-06 | ニュー・イングランド・バイオラブズ・インコーポレイティッド | Methods and compositions for DNA manipulation |
WO2005026686A2 (en) * | 2003-09-09 | 2005-03-24 | Compass Genetics, Llc | Multiplexed analytical platform |
-
2006
- 2006-03-16 EP EP06738889A patent/EP1856293A2/en not_active Ceased
- 2006-03-16 WO PCT/US2006/009898 patent/WO2006099604A2/en active Application Filing
- 2006-03-16 US US11/377,462 patent/US20060211030A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999028505A1 (en) * | 1997-12-03 | 1999-06-10 | Curagen Corporation | Methods and devices for measuring differential gene expression |
US20030049616A1 (en) * | 2001-01-08 | 2003-03-13 | Sydney Brenner | Enzymatic synthesis of oligonucleotide tags |
Also Published As
Publication number | Publication date |
---|---|
US20060211030A1 (en) | 2006-09-21 |
EP1856293A2 (en) | 2007-11-21 |
WO2006099604A2 (en) | 2006-09-21 |
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