WO2006066462A1

WO2006066462A1 - Photoelectric detection device for single photon counter

Info

Publication number: WO2006066462A1
Application number: PCT/CN2004/001518
Authority: WO
Inventors: Jiang Lan; Jinsheng Yu; Xiaolin Yang; Xiaodong Wu
Original assignee: Beijing Yuande Bio-Medical Engineering Co., Ltd.
Priority date: 2004-12-24
Filing date: 2004-12-24
Publication date: 2006-06-29

Abstract

A photoelectric detection device for single photon counter, which includes a case, an entrance window for photons from samples, a photodetector for receiving the photons that pass through said entrance window, a socket portion for receiving said photodetector, a bleeder circuit board for providing electric power for said photodetector, and a preprocessing circuit board for processing electric signal that output from said photodetector, wherein said bleeder circuit board and said preprocessing circuit board are mounted on the back of said socket portion as compact as possible, and are built in said case which has good light and magnetic shielding performance in company with said photodetector.

Description

Technical field

The present invention relates to a single photon counter, and in particular to a photodetection device for a single photon counter.

Background technique

The determination of various hormones, drugs, vitamins, tumors and infection-related substances has become one of the routine inspections in hospitals. However, the radioimmunoassay technology used in the past has a short half-life, is not conducive to storage, is easy to cause harm to people and the environment, and has insufficient detection sensitivity. In the 1990s, a photobiological marker and detection technology represented by chemiluminescence appeared, which was not only simple, fast, and safe, but also had higher sensitivity, so it was quickly applied to clinical diagnosis.

The single photon counter is a device that is matched with the corresponding detection reagent and detected by chemiluminescence. It uses a single photon counting method to quantitatively detect the very weak luminescence intensity of the treated sample.

Compared with previous radioimmunoassay technologies, single-photon counters are used in hospitals for the determination of various hormones, drugs, vitamins, tumors and infection-related substances, with higher sensitivity, easier, faster and safer.

The prior art photodetection circuit for single photon counting generally comprises four parts:

1. Photodetector, generally installed in a shell that is protected from light and has electromagnetic shielding;

2. A preamplifier for amplifying the weak signal output by the photodetector;

3. A voltage comparator for removing a noise signal output from the amplifier and converting an analog electrical signal exceeding a certain threshold into an electrical pulse signal;

4, the counter, according to a certain time interval to the output pulse of the voltage comparator The line counts and outputs the count value.

Since the detected light intensity is extremely weak, the output signal of the photodetector is also weak, and its output pulse width is very narrow (requires a high frequency upper limit of the processing circuit), so its signal processing circuit is susceptible to noise and surrounding clutter. Interference. Summary of the invention

SUMMARY OF THE INVENTION An object of the present invention is to provide a photodetecting device capable of avoiding disturbances and reducing noise levels to improve detection sensitivity.

According to an aspect of the invention, a photodetecting device for a single photon counter includes: a housing; a detection window for inputting photons from the sample to be inspected; a photodetector receiving the photons through the detection window; , for receiving the photodetector; a voltage-dividing power supply circuit board for supplying power to the photodetector; and a pre-processing circuit board for processing an electrical signal output by the photodetector,

The utility model is characterized in that the voltage-dividing power supply circuit board and the pre-processing circuit board are mounted to the rear of the pipe socket in a compact structure as possible, and are mounted together with the photodetector to have a good shading And electromagnetic shielding performance in the housing.

According to another aspect of the invention, wherein the photodetector is a photomultiplier tube.

The photodetection device for a single photon counter of the present invention not only ensures high frequency characteristics of the processing circuit but also effectively reduces electromagnetic interference and noise levels. DRAWINGS

The objects and contents of the present invention will be more apparent from the detailed description of the drawings and the embodiments below.

Figure 1 shows the structural arrangement of a photodetecting device for a single photon counter in accordance with the present invention. detailed description

Fig. 1 shows an embodiment of a photodetecting device according to the present invention, in which a window 1 is detected for inputting photons from a sample to be inspected. The photomultiplier tube 2 serves as a photodetector through which the photons are received. Photomultiplier tube

2 Mounted on the base 3. A voltage dividing power supply circuit board 4 for the photomultiplier tube dynode is used to supply power to the plurality of dynodes of the photomultiplier tube. The pre-processing circuit board 5 is for processing the electrical signal output from the photomultiplier tube 2. The pre-processing circuit generally includes a preamplifier circuit, a voltage comparison circuit, and a high-speed counter (divider). In order to ensure the high-frequency characteristics of the processing circuit and to effectively reduce the electromagnetic interference and noise level, the voltage-dividing power supply circuit board 4 and the pre-processing circuit board 5 are mounted to the photomultiplier tube base 3 in a compact structure as possible. The rear portion is mounted with the photomultiplier tube 2 into a housing 6, 7, 8, 9, 10 having better shading and electromagnetic shielding properties.

One embodiment of the present invention has been described above, and provides a structural arrangement of a photodetecting device for a single photon counter. However, it is apparent to those skilled in the art that various modifications may be made without departing from the scope of the invention as claimed.

Claims

1. A photodetecting device for a single photon counter comprising:

Housing

a detection window for inputting photons from the sample to be inspected;

a photodetector, receiving the photon through the detection window;

a base for receiving the photodetector;

a voltage dividing power supply circuit board for supplying power to the photodetector; and

a pre-processing circuit board for processing an electrical signal output by the photodetector, characterized in that the voltage-dividing power supply circuit board and the pre-processing circuit board are mounted to the rear of the tube seat in a compact structure as possible And mounted with the photodetector in a housing having better shading and electromagnetic shielding properties.

2. The photodetecting device according to claim 1, wherein said photodetector is a photomultiplier tube.

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