WO2006055925A3 - Microarrays for analyte detection - Google Patents

Microarrays for analyte detection Download PDF

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Publication number
WO2006055925A3
WO2006055925A3 PCT/US2005/042209 US2005042209W WO2006055925A3 WO 2006055925 A3 WO2006055925 A3 WO 2006055925A3 US 2005042209 W US2005042209 W US 2005042209W WO 2006055925 A3 WO2006055925 A3 WO 2006055925A3
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WO
Grant status
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Patent type
Prior art keywords
microarrays
therapeutics
adhesion
cell
pathogens
Prior art date
Application number
PCT/US2005/042209
Other languages
French (fr)
Other versions
WO2006055925A2 (en )
Inventor
Peter H Seeberger
Matthew David Disney
Original Assignee
Swiss Fed Inst Of Technology
Peter H Seeberger
Matthew David Disney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates

Abstract

On embodiment of the present invention describes the use of microarrays to investigate the carbohydrate binding specificities of bacteria, to detect pathogens, and to screen anti-adhesion therapeutics is reported. This system is ideal for whole cell applications because microarrays present carbohydrate ligands in a manner that mimics interactions at cell-cell interfaces. Other advantages include assay miniaturization, since minimal amounts (e.g., on the order of picomoles) of a ligand (i.e., a biological recognition element) are required to observe binding, and high-throughput, since thousands of compounds can be placed on an array and analyzed in parallel. Pathogen detection experiments can be completed in complex mixtures of cells or protein using the known carbohydrate binding epitopes of the pathogens in question. The non-destructive nature of the arrays allows the pathogen to be harvested and tested for antibacterial susceptibility. These investigations allow microarray-based screening of biological samples for contaminants and combinatorial libraries for anti-adhesion therapeutics.
PCT/US2005/042209 2004-11-19 2005-11-21 Microarrays for analyte detection WO2006055925A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US62892704 true 2004-11-19 2004-11-19
US60/628,927 2004-11-19

Publications (2)

Publication Number Publication Date
WO2006055925A2 true WO2006055925A2 (en) 2006-05-26
WO2006055925A3 true true WO2006055925A3 (en) 2006-11-30

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ID=36407853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/042209 WO2006055925A3 (en) 2004-11-19 2005-11-21 Microarrays for analyte detection

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WO (1) WO2006055925A3 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008115198A9 (en) 2006-06-30 2008-12-24 Univ Georgia Res Found Anthrax carbohydrates,synthesis and uses thereof
US8420607B2 (en) 2006-06-30 2013-04-16 University Of Georgia Research Foundation, Inc. Anthrax carbohydrates, synthesis and uses thereof
US20110053793A1 (en) * 2007-12-21 2011-03-03 Alberto Monasterio Methods and products for identifying strains of bacteria
ES2442024T3 (en) * 2008-07-15 2014-02-07 Academia Sinica Glycan arrays on glass slides coated with PTFE-like aluminum and related methods
US8680023B2 (en) * 2008-08-21 2014-03-25 International Business Machines Corporation Methods for screening and arraying microrganisms such as viruses using subtractive contact printing background
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
CA2880765A1 (en) * 2012-08-23 2014-02-27 Stemcell Technologies Inc. Compositions and methods for rapid and reversible biomolecular labeling
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
EP3013347A4 (en) 2013-06-27 2017-01-18 Academia Sinica Glycan conjugates and use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
JP2017523131A (en) 2014-05-27 2017-08-17 アカデミア シニカAcademia Sinica Anti her2 glycoengineered antibody group and their use
US9057508B1 (en) 2014-10-22 2015-06-16 Codeshelf Modular hanging lasers to enable real-time control in a distribution center
US9327397B1 (en) 2015-04-09 2016-05-03 Codeshelf Telepresence based inventory pick and place operations through robotic arms affixed to each row of a shelf
US9262741B1 (en) 2015-04-28 2016-02-16 Codeshelf Continuous barcode tape based inventory location tracking

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150103A (en) * 1997-07-22 2000-11-21 Qiagen Genomics, Inc. Polyethylenimine-based biomolecule arrays

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150103A (en) * 1997-07-22 2000-11-21 Qiagen Genomics, Inc. Polyethylenimine-based biomolecule arrays

Also Published As

Publication number Publication date Type
WO2006055925A2 (en) 2006-05-26 application

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