WO2006040156A1

WO2006040156A1 - Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines

Info

Publication number: WO2006040156A1
Application number: PCT/EP2005/011021
Authority: WO
Inventors: Richard Desmond; Paul N. Devine; Clas Sonesson; Donald R. Gautier
Original assignee: Neurosearch Sweden Ab
Priority date: 2004-10-13
Filing date: 2005-10-13
Publication date: 2006-04-20
Also published as: JP2008515952A; US20070238878A1; NZ555095A; KR20070064370A; EP1807394A1; CN101068782A; MX2007004216A; CA2584833A1; AU2005293755A1

Abstract

The present invention is directed to processes for the preparation of 4-(sulfonylphenyl)-piperidines of the Formula (VI), and pharmaceutically acceptable salts thereof; which comprises oxidizing a sulfide of the Formula (VII) or Formula (VIII), to give a compound of the Formula (IX) or Formula (X) respectively, followed by catalic reduction of the compound of the Formula (IX) or dehydration of compound of formula (X) to give a compound of Formula (IX) followed by catalytic reduction of the compound of formula (IX) to give the compound of the Formula (VI).

Description

TITLE OF THE INVENTION

PROCESS FOR THE SYNTHESIS OF 4- (3-SULFONYLPHENYL) -PIPERIDINES

BACKGROUND OF THE INVENTION

4-(3-Methanesulfonylphenyl)-l-N-propylpiperidine is useful as a modulator of dopamine neurotransmission and has therapeutic application for example in the treatment of Alzheimer's disease, Parkinson's disease and schizophrenia. Synthetic methods to prepare 4-(sulfonylphenyl) piperidines have been described in PCT Patent Publications WO 01/46145 and WO 01/46145.

In accordance with the present invention, processes are provided for the preparation of 4- (sulfonylphenyl)piperidines, and pharmaceutically acceptable salts thereof. The subject process provide 4-(sulfonylphenyl)piperidines in high yield and purity while minimizing the number of synthetic steps.

SUMMARY OF THE INVENTION

The present invention is directed to processes for the preparation of 4-(sulfonylphenyl)- piperidines of the formula VI:

VI

wherein:

Rl is selected from the group consisting of:

(1) -CH₃, and

(2) -CH₂CH₃;

R2 is selected from the group consisting of:

(1) -CH₂CH₃,

(2) -CH₂CH₂CH₃,

(3) -CH₂CH₂CH₂CH₃,

(4) -CH(CH₃)CH₂CH₃,

(5) -CH₂CH(CH₃)₂,

(6) -CH₂CH₂OCH₃, and (7) -CH₂CH=CH₂; R3 is selected from the group consisting of:

(1) hydrogen, and

(2) fluoro;

R4 is selected from the group consisting of:

(1) hydrogen, and

(2) fluoro;

and pharmaceutically acceptable salts thereof.

10

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to process for the preparation of 4-(sulfonylphenyl)- piperidines which are useful as pharmaceutical agents.

An embodiment of the present invention is directed to a process for the preparation of a

1.5 4-(sulfonylphenyl)-piperidine of the formula VI:

VI

20 wherein:

R1 is selected from the group consisting of:

(1) -CH₃, and

(2) -CH₂CH₃;

25 R2 is selected from the group consisting of:

(1) -CH₂CH₃,

(2) -CH₂CH₂CH₃,

(3) -CH₂CH₂CH₂CH₃,

(4) -CH(CH₃)CH₂CH₃,

30 (5) -CH₂CH(CH₃)₂, (6) -CH₂CH₂OCH₃, and

(7) -CH₂CH=CH₂;

R3 is selected from the group consisting of:

(1) hydrogen, and

(2) fluoro;

R4 is selected from the group consisting of:

(1) hydrogen, and

(2) fluoro;

and pharmaceutically acceptable salts thereof; which comprises oxidizing a sulfide of the formula VII or VIII:

VII VIII

to give a compound of the formula IX or X, respectively:

IX X followed by catalytic reduction of the compound of the formula IX or dehydration of compound of formula X to give a compound of formula IX followed by catalytic reduction of the compound of formula IX to give the compound of the formula VI:

VI or a pharmaceutically acceptable salt thereof.

The present invention also relates to the above routes individually. In a preferred embodiment of the invention, Rβ and R.4 are not H when Rl = Me and R2 = n-Pr.

An embodiment of the present invention is directed to a process for the preparation of l-ethyl-4-[2-fluoro-3-(methylsulfonyl)phenyl]piperidine of the formula I:

I or a pharmaceutically acceptable salt thereof, which comprises oxidizing a sulfide of the formula II:

II to give a compound of the formula III:

III followed by catalytic reduction of the compound of the formula III to give the compound of the formula I:

I or a pharmaceutically acceptable salt thereof.

A further embodiment of the present invention is directed to a process for the preparation of l-ethyl-4- [2-fluoro-3-(methylsulfonyl)phenyl]piperidine of the formula I:

I or a pharmaceutically acceptable salt thereof, which comprises oxidizing a sulfide of the formula IV

IV

to give a compound of the formula V:

v

followed by dehydration of the compound of the formula V with strong acid; to give the compound of the formula III:

III

followed by catalytic reduction of the compound of the formula III; to give the compound of the formula I:

or a pharmaceutically acceptable salt thereof.

or a pharmaceutically acceptable salt thereof, which further comprises; dehydrating an alcohol of the formula IV:

IV with a strong acid; to give a sulfide of the formula II:

II

oxidizing the sulfide of the formula III to give a compound of the formula III:

III

or a pharmaceutically acceptable salt thereof.

A further embodiment of the present invention is directed to a process for the preparation of l-ethyl-4-[3-fluoro-5-(methylsulfonyl)phenyl]piperidine of the formula XI:

XI or a pharmaceutically acceptable salt thereof, which comprises oxidizing a sulfide of the formula XII:

XII

to give a compound of the formula XIII:

XIII followed by catalytic reduction of the compound of the formula XIII; to give the compound of the formula XI:

XI or a pharmaceutically acceptable salt thereof.

XI or a pharmaceutically acceptable salt thereof, which further comprises dehydrating an alcohol of the formula XIV:

XIV with a strong acid; to give a sulfide of the formula XII:

XII

followed by oxidizing the sulfide of the formula XII to give a compound of the formula XIII:

XIII followed by catalytic reduction of the compound of the formula XIII to give the compound of the formula XI:

XI or a pharmaceutically acceptable salt thereof.

A further embodiment of the present invention is directed to a process for the preparation of l-ethyl-4- [3-fluoro-5-(methylsulfonyl)phenyl]piperidine of the formula XI:

XI

or a pharmaceutically acceptable salt thereof, which further comprises oxidizing the sulfide of the formula XIV

XIV

to give a compound of the formula XV:

XV

followed by dehydrating of the compound of the formula XV with a strong acid to give a compound of the formula XIII:

XIII

followed by catalytic reduction of the compound of the formula XIII to give the compound of the formula XI:

XI

or a pharmaceutically acceptable salt thereof

In an embodiment of the present invention the strong acid is a strong inorganic acid or a strong organic acid. In an embodiment of the present invention the strong acid is selected from sulfuric acid, hydrochloric acid, hydrofluoric acid, phosphoric acid, polyphosphoric acid, nitric acid and trifluoroacetic acid. Optionally, the dehydration of the alcohols of the formulae VIII, IV, XIV, X, V or

XV with a strong acid is conducted neat or in a solvent. In an embodiment of the present invention the solvent is selected from toluene, xylene, hexanes and water.

In an embodiment of the present invention, oxidizing a sulfide of the formula VII, II,

XII, IV, XIV or VIII is carried out using a catalytic oxidizing agent, such as a tungsten, ruthenium, rhenium, molybdenum, osmium, silicotungstate (e.g. (Bu₄N)₄[Y-SiWi₀O₃₄(H₂O)₂]) or chromium oxidizing agent. The addition of imidazole, phosphate, or carboxylates significantly enhances the rate of organic sulfide oxygenation. In an embodiment of the present invention the catalytic oxidizing agent is a tungsten oxidizing agent. In an aspect of this embodiment, the tungsten oxidizing agent is sodium tungstate.

In an embodiment of the present invention the oxidant is a peroxide. In an aspect of this embodiment, the peroxide is sodium peroxide, hydrogen peroxide, sodium hypochlorite, sodium bromate, sodium periodate, peroxyacetic acid or peroxybenzoic acid. In a further aspect of this embodiment, the peroxide is sodium peroxide. Within this embodiment, the peroxide is an aqueous solution of sodium peroxide.

In another embodiment of the present invention, oxidizing a sulfide of the formula VII, II, XII, IV, XIV or VIII is carried out using a stoichiometric oxidant. Preferred stoichiometric oxidants are peroxides, oxone, MCPBA or KMnO₄. Catalytic oxidizing agents as detailed above are, however, preferable.

In an embodiment of the present invention the step of oxidizing the sulfide of the formula VII, II, XII, IV, XIV or VIII is conducted at less than 3 pH. Within this embodiment, the step of oxidizing the sulfide of the formula VII, II, XII, IV, XIV or VIII is conducted at less than 2 pH. Further within this embodiment, the step of oxidizing the sulfide of the formula VII, II, XII, IV, XIV or VIII is conducted at less than 1 pH.

In an embodiment of the present invention the step of oxidizing the sulfide of the formula VII, II, XII, IV, XIV or VIII is conducted at a temperature greater than 30⁰C (inclusive). Within this embodiment, the step of oxidizing the sulfide of the formula VII, II, XII, IV, XIV or VIII is conducted at a temperature greater than 40⁰C (inclusive). Further within this embodiment, the step of oxidizing the sulfide of the formula VII, II, XII, IV, XIV or VIII is conducted at a temperature between 40⁰C and 60⁰C (inclusive). Further within this embodiment, the step of oxidizing the sulfide of the formula VII, II, XII, TV, XIV or VIII is conducted at a temperature between 50⁰C and 55°C (inclusive).

Preferred solvents for conducting the step of oxidizing the sulfide of the formula VII, II, XII, IV, XTV or VIII comprise an aqueous solution with an organic solvent which is selected from toluene, tetrahydrofuran (THF), diethyl ether, diglyme and methyl t-butyl ether. The most preferred organic solvent is toluene.

In an embodiment of the present invention the step of catalytic reduction of the compound of the formula IX, III or XIII comprises catalytic hydrogenation. Within this embodiment, the step of catalytic reduction of the compound of the formula IX, III or XIII comprises catalytic hydrogenation with a palladium catalyst, a platinum catalyst or a ruthenium catalyst. Within this embodiment, the step of catalytic reduction of the compound of the formula IX, III or XIII comprises catalytic hydrogenation with a palladium catalyst. Within this embodiment, the step of catalytic reduction of the compound of the formula IX, III or XIII comprises catalytic hydrogenation with a palladium on carbon catalyst. Further within this embodiment, the step of catalytic reduction of the compound of the formula IX, III or XIII comprises catalytic hydrogenation with a 10% palladium on carbon catalyst or a 5% palladium on carbon catalyst.

In an alternate embodiment of the present invention the step of catalytic reduction of the compound of the formula IX, III or XIII comprises catalytic transfer hydrogenation. Within this embodiment, the step of catalytic reduction of the compound of the formula IX, III or XIII comprises catalytic transfer hydrogenation with a rhodium catalyst or a ruthenium catalyst and a hydrogen transfer source. Within this embodiment, the rhodium catalyst may be selected from bis((pentamethylcyclopentadienyl)rhodium chloride) and bis((cyclopentadienyl)rhodium chloride), optionally in the presence of alternate ligands. Within this embodiment, the ruthenium catalyst may be selected from bis((4-isopropyl-toluenyl)ruthenium chloride) and bis((cyclopenta-dienyl)ruthenium chloride), optionally in the presence of alternate ligands. Within this embodiment, the hydrogen transfer source may be an acid or an alcohol, such as formic acid, methanol, ethanol, isopropanol, isobutanol or n-butanol. In this embodiment, a base is optionally present with the hydrogen transfer source. The base may be an inorganic base such as a base selected from potassium or sodium hydroxide, potassium or sodium carbonate, potassium or sodium bicarbonate potassium or sodium alkoxides, and the like. The alkoxides can be derived from lower (C₁-C₅) or higher (>C₆) primary, secondary or tertiary alcohols.

Solvents for conducting the step of catalytic reduction of the compound of the formula IX, III or XIII include an aqueous solution with an alcohol, such as an alcohol selected from methanol, ethanol, isopropanol, isobutanol or n-butanol. Within this embodiment, the alcohol may be methanol.

The term "pharmaceutically acceptable salts" refers to salts prepared from pharmaceutically acceptable non-toxic bases or acids including inorganic or organic bases and inorganic or organic acids. Salts may be prepared from pharmaceutically acceptable non-toxic acids, including inorganic and organic acids. Such acids include acetic, benzenesulfonic, benzoic, camphorsulfonic, citric, ethanesulfonic, fumaric, gluconic, glutamic, hydrobromic, hydrochloric, isethionic, lactic, maleic, malic, mandelic, methanesulfonic, mucic, nitric, pamoic, pantothenic, phosphoric, succinic, sulfuric, tartaric, p-toluenesulfonic acid, and the like. Particularly preferred are benzenesulfonic, citric, hydrobromic, hydrochloric, maleic, fumaric, succinic and tartaric acids. It will be understood that, as used herein, references to the compounds of the present invention are meant to also include the pharmaceutically acceptable salts.

The starting materials and reagents for the subject processes are either commercially available or are known in the literature or may be prepared following literature methods described for analogous compounds. The skills required in carrying out the reaction and purification of the resulting reaction products are known to those in the art. Purification procedures include crystallization, distillation, normal phase or reverse phase chromatography.

The following Examples are provided by way of illustration only, and in no way are meant to limit the scope of the invention.

EXAMPLE 1

Materials Amount Moles

2,2,6,6-tetramethylpiperidine 0.226 kg 1.6 eq

THF 0.6 L

Hex-Li (33 % in Hexane) 0.598 L 1.5 eq

1 -bromo-2-fluorobenzene 0.175 kg 1.0 eq CH3SSCH3 0.133 L 1.5 eq

THF 0.7 L

Methyl acrylate 0.180 L 2.0 eq

2 M NaOH 1.4 L 8 eq

MTBE 2 x 1, 4 L

2 M HCl 2 x l.ι 05 L

To a solution of 2,2,6,6-tetramethylpiperidine in tetrahydrofuran under nitrogen atmosphere at -50 ⁰C was added hexyllithium (- 50 ⁰C to - 30 ⁰C) The mixture was allowed to warm to ambient temperature and added to a solution of 1 -bromo-2-fluorobenzene and dimethyldisulfide in tetrahydrofuran at —78 ⁰C (- 80 ⁰C to - 60⁰C). The mixture was slowly allowed to warm to ambient temperature, cooled to 0⁰C, and quenched with methylacrylate with the reaction temperature maintained < 30 ⁰C throughout the addition followed by the addition of NaOH (2 M). The organic solvent was evaporated and the aqueous phase was extracted with tert-butyl methyl ether . The organic phase was washed with an aqueous solution of hydrochloric acid (2 M) and the combined organic phase was evaporated to dryness to give an oil. The residue was purified by column chromatography using 7 mass equivalents of silica compared to the residue and using heptane as the eluent to give the title compound. MS m/z (relative intensity, 70 eV) 222 (M+, bp), 220 (M+, 91), 189 (24), 187 (25), 126 (97).

EXAMPLE 2

Materials Amount Moles l-bromo-2-fluoro-3-(methylthio)benzene 11.0 kg 1.0 eq

THF 55 L

Hex-Li (33 % in Hexane) 14 L 1.0 eq

1 -Ethyl-4-piperidone 6.012 kg 0.95 eq

THF 2 L

MeOH 4 L

5 M HCl 44 L

Heptane 44 L

MTBE 43 L

30 % NaOH 33 L i-PrOAc 66 L

Sat NaCl 44 L

To a -78 ⁰C solution of l-bromo-2-fluoro-3-(methylthio)benzene in THF under a nitrogen atmosphere, was added hexyllithium over 50 minutes with the reaction temperature maintained < -60 ⁰C throughout the addition. The mixture was stirred for 1 min at -78 ⁰C and then 1 -ethyl-4-piperidone was added over 50 min. with the reaction temperature maintained < -60 ⁰C throughout the addition. The mixture was stirred at -75 ⁰C to - 70 ⁰C for 60 min. The reaction mixture was then quenched with MeOH at - 70 ⁰C to - 60 ⁰C over a period of 9 minutes and then brought to room temperature. The reaction mixture was treated with 5 M HCl at 0 - 15 ⁰C over a period of 50 minutes. The aqueous mixture was first extracted with heptane and then TBME. The aqueous layer was then basified with 30% NaOH at 0 - 15 ⁰C over a period of 50 minutes and then extracted with i-PrOAc. The organic layer was washed with brine and then evaporated to dryness yielding 11.2 kg of an oily residue.. MS m/z (rel. intensity, 70 eV) 269 (M+, 49), 254 (bp), 236 (36), 169 (13), 109 (17).

EXAMPLE 3

A solution of l-ethyl-4-[2-fluoro-3-(methylthio)phenyl]piperidin-4-ol (42 g, 156 mmol) and sulfuric acid (18 M, 8.5 ml, 156 mmol) in toluene (200 ml) was refluxed under a Dean-Stark water separator for 15 h. The solution was cooled to ambient temperature, water was added and the phases were separated in a separation funnel. The aqueous phase was cooled to 0 ⁰C, made basic with a sodium hydroxide solution (5 M) and extracted with ethyl acetate (2 x 100 ml). The combined organic phase was dried (MgSO4) and concentrated to afford the title compound (22.6 g). MS m/z (rel. intensity, 70 eV) 251 (M+, bp), 236 (85), 147 (65), 146 (45), 110 (44).

EXAMPLE 4

Materials Amount Moles l-ethyl-4-[2-fluoro-3-(methylthio)phenyl] 11.0 kg 1.0 eq piperidin-4-ol

Trifluoroacetic acid 42 L Reactor was loaded with l-ethyl-4-[2-fluoro-3-(methylthio)phenyl]piperidin-4-ol and trifluoroacetic acid and purged with nitrogen (exothermic). The mixture was heated to 82-85 ⁰C for 20 h. The solution was then cooled to room temperature. MS m/z (rel. intensity, 70 eV) 251 (M+, bp), 236 (85), 147 (65), 146 (45), 110 (44).

EXAMPLE 5

To a solution of l-ethyl-4-[2-fluoro-3-(methylthio)phenyl]-l,2,3,6-tetrahydropyridine (22.5 g, 89.6 mmol) in sulfuric acid (1 N, 180 ml) was added sodiumtungstate dihydrate (0.29 g, 0.89 mmol), and hydrogenperoxide (30% in water, 22,9 ml, 224 mmol) was added in a rate that kept the temperature below 55 ⁰C. The mixture was stirred for 2 h and cooled to 10 ⁰C. The aqueous phase was made basic with a sodium hydroxide solution (5 M) and extracted with ethyl acetate (2 x 100 ml). The combined organic phase was dried (MgSO4), concentrated, and purified by flash column chromatography (ethylacetate/methanol 1:1) to give the title compound (17.2 g). MS m/z (rel. intensity, 70 eV) 283 (M+, 63), 282 (29), 268 (bp), 146 (51), 110 (87).

EXAMPLE 6

Materials Amount Moles l-ethyl-4-[2-fluoro-3-(methylthio)phenyl]- 23.5 L 1.0 eq 1 ,2,3 ,6-tetrahydropyridine Water 49 kg

Oxone 13.3 + 3.6 kg 1.1 + 0.1 + 0.1 + 0.1 eq

Na₂SO₃ sol (saturated) H L iPrOAc 21 L

30 % NaOH 36 L iPrOAc 2 x 21 L

NaCl sol (saturated) 32 L iPrOAc 12 L

Silica 20 kg

The solution from Example 4 was divided into two portions 23.5 L of each. The first portion was diluted with water at -3.5 ⁰C to 7.5 ⁰C (exothermic). Oxone was added during 90 min at -7 ⁰C to -8.5 ⁰C and then the reaction mixture was kept at - 7 ⁰C to 0 ⁰C for 4.5 h and then warmed to 20 ⁰C over a period of 120 min. The final reaction mixture was stirred at room temperature for 12 h. Oxone was then redosed 3 times. at room temperature in intervals of 6-10 h. The final reaction mixture was quenched with saturated sodium sulfite solution at 0⁰C. The reaction solution was extracted with iPrOAc and then basifϊed at 0 ⁰C with 30 % NaOH. The final water solution was extracted 2 times with iPrOAc and the combined organic phases were washed with brine. The solvents were evaporated and the final oily residue was purified with chromatography using heptane /EtOAc (1:1) + 5 % NEt₃ as the eluting system to give the title compound (17.2 g). MS m/z (rel. intensity, 70 eV) 283 (M+, 63), 282 (29), 268 (bp), 146 (51), 110 (87).

EXAMPLE 7

A mixture of l-ethyl-4-[2-fluoro-3-(methylsulfonyl)phenyl]-l,2,3,6-tetrahydropyridine (5.0 g, 17.7 mmol), palladium on carbon (1.1 g) and formic acid (3.4 ml) in 2-propanol (50 ml) was hydrogenated under hydrogen at 50 psi for 15 h. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated and evaporated to dryness. Aqueous sodium carbonate (10%, 100 ml) and ethylacetate (100 ml) was added and the phases were separated. The aqueous phase was extracted with ethylacetate (2x50 ml) and the combined organic phases was dried (MgSO4) and evaporated under reduced pressure to give an oil. Purification by flash column chromatography (ethylacetate/methanol, 1:1) gave the title compound: 2.5 g (50%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 279-280 ⁰C. MS m/z (relative intensity, 70 eV) 285 (M+, 12), 271 (15), 270 (bp), 147 (7) 133 (8).

EXAMPLE 8

Materials Amount Moles l-ethyl-4-[2-fluoro-3-(methylthio)phenyl]-l-l,2,3,6- 5.308 kg 1.0 eq tetrahydropyridine

10% Pd/C (55-57% wet, type 87L paste from JM) 4.533 kg

Ca(OAc)2 296 g 0.1 eq

Ethanol 53 L

Acetic Acid 5.4 L 5.0 eq

H2 1150 L

Celite 5.335 kg

Ethanol 10 + 26 L

TBME 53 L

NaOH (5 M ) 21 L

TBME 26.4 L

Sat NaCl 21 + 21 L

TBME 5 L

Silica gel 42 kg

EtOH 9O L

HCl (1.25 M in EtOH) 6.35 L The reactor was loaded with Pd/C catalyst and Ca(O Ac)2. Then the reactor was purged with nitrogen followed by addition of l-ethyl-4-[2-fluoro-3-(methylsulfonyl)phenyl]-l,2,3,6-tetrahydropyridine, EtOH and acetic acid. The mixture was hydrogenated with hydrogen gas over a period of 12 h. The mixture was then filtered through a pad of celite which was then rinsed with EtOH. The EtOH was then evaporated and the remaining residue treated with 5 M NaOH solution. The water phase was then extracted with TBME. The combined organic phases were washed with brine and then concentrated to yield an oily residue which was purified with chromatography using heptane /EtOAc (1 : 1) + 5 % NEt₃ as the eluting system to give the title compound. The amine was then dissolved in EtOH and HCl in EtOH was added at 60 ⁰C. The final solution was slowly cooled to 20 ⁰C and the crystallisation started. The final suspension was stirred for 1 h at 20 ⁰C and then the crystals were filtered off and dried to yield 3.2 kg of final product. M.p. 284 ⁰C. MS m/z (relative intensity, 70 eV) 285 (M+, 12), 271 (15), 270 (bp), 147 (7) 133 (8).

EXAMPLE 9

To a solution of l-bromo-3,5-difluorobenzene (5.0 g, 25.9 mmol) in dimethylformamide (40 ml) was added sodiumthiomethylate (1.81 g, 25.9 mmol), and the mixture was heated to 150 ⁰C for 10 min. The reaction mixture was brought to ambient temperature, quenched with saturated aqueous ammonium chloride (100 ml) and extracted with ethylacetate (3x100 ml). The combined organic phases was dried (MgSO4) and concentrated in vacuo to receive the pure title compound (3.84 g). MS m/z (rel. intensity, 70 eV) 222 (M+, 100), 220 (M+, 100), 189 ^'(49), 187 (50), 126 (75). EXAMPLE 10

Preparation according Example 2: l-bromo-3-fluoro-5-(methylthio)benzene (3.8 g, 17.4 mmol), dry tetrahydrofuran (70 ml), n-butyllithium (2.5 M in hexane, 7.7 ml, 19.1 mmol), l-ethyl-4-piperidone (2.2 g, 17.4 mmol). Yield: 4.7 g. MS m/z (rel. intensity, 70 eV) 269 (M+, 73), 254 (bp), 236 (34), 109 (136), 84 (75).

EXAMPLE I l

To a solution of l-ethyl-4-[3-fluoro-5-(methylthio)phenyl]piperidin-4-ol (8.3 g, 30.7 mmol) in methylene chloride (40 ml), acetonitrile (40 ml) and water (80 ml), was added sodium periodate (19.7 g, 92.1 mmol) and ruthenium (III) chloride (15 mg, 0.05 mol%). The mixture was stirred for 0.5 h, made basic with with a sodium hydroxide solution (1 M, 50 ml) and extracted with ethyl acetate (2 x 100 ml). The combined organic phase was dried (MgSO4) and concentrated to give the title compound (5.2 g). MS m/z (rel. intensity, 70 eV) 301 (M+, 21), 287 (16), 286 (bp), 256 (64), 84 (42). EXAMPLE 12

A mixture of l-ethyl-4-[3-fluoro-5-(methylsulfonyl)phenyl]piperidin-4-ol (5.2 g, 17.3 mmol) and polyphosphoric acid (15 ml) was heated at HO⁰C for 1 h. The mixture was poured on to ice and was basified with 5 M sodium hydroxide. The mixture was extracted with ethylacetate (3x100 ml) and the combined organic phases was dried (MgSO4), filtered and evaporated to dryness to give an oil. The crude product was purified by flash column chromatography (ethylacetate/methanol 1:1) to give the title compound (2.2 g). MS m/z (rel. intensity, 70 eV) 283 (M+, 76), 282 (36), 268 (bp), 146 (18), 110 (19).

EXAMPLE 13:

Preparation according to example 1: l-ethyl-4-[3-fluoro-5-(methylsulfonyl)phenyl]-l,2,3,6- tetrahydropyridine (2.2 g, 7.7 mmol), palladium on carbon (0.43 g), formic acid (1.5 ml) and 2-propanol (50 ml). Yield: 1.9 g (87%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 176-178 ⁰C. MS m/z (relative intensity, 70 eV) 285 (M+, 15), 284 (16), 271 (16), 270 (bp), 84 (15).

While the invention has been described and illustrated with reference to certain particular embodiments thereof, those skilled in the art will appreciate that various adaptations, changes, modifications, substitutions, deletions, or additions of procedures and protocols may be made without departing from the spirit and scope of the invention. For example, reaction conditions other than the particular conditions as set forth herein above may be applicable as a consequence of variations in the reagents or methodology to prepare the compounds from the processes of the invention indicated above. Likewise, the specific reactivity of starting materials may vary according to and depending upon the particular substituents present or the conditions of manufacture, and such expected variations or differences in the results are contemplated in accordance with the objects and practices of the present invention. It was intended, therefore, that the invention be defined by the scope of the claims which follow.

Claims

WHAT IS CLAIMED IS:

1. A process for preparing a compound of the formula VI:

VI wherein:

Rl is selected from the group consisting of:

(1) -CH₃, and (2) -CH₂CH₃;

R2 is selected from the group consisting of:

(1) -CH₂CH₃,

(2) -CH₂CH₂CH₃,

(3) -CH₂CH₂CH₂CH₃, (4) -CH(CH₃)CH₂CH₃,

(5) -CH₂CH(CH₃)₂,

(6) -CH₂CH₂OCH₃, and

(7) -CH₂CH=CH₂;

Its is selected from the group consisting of: (1) hydrogen, and

(2) fluoro;

R4 is selected from the group consisting of:

(3) hydrogen, and

(4) fluoro; and pharmaceutically acceptable salts thereof; which comprises oxidizing a sulfide of the formula VII or VlII:

VII VIII

to give a compound of the formula IX or X, respectively:

VI or a pharmaceutically acceptable salt thereof.

2. A process according to claim 1 for preparing a compound of the formula VI:

VI

wherein Rl, R^, R3 and R4 are as defined in claim 1, and pharmaceutically acceptable salts thereof; which comprises oxidizing a sulfide of the formula VII:

VII

to give a compound of the formula IX:

IX

followed by catalytic reduction of the compound of the formula IX to give the compound of the formula VI:

VI or a pharmaceutically acceptable salt thereof.

3. The process according to claim 2, which further comprises dehydrating an alcohol of the formula VIII:

VIII wherein Rl, R2, R3 and R4 are as defined in claim 1, and pharmaceutically acceptable salts thereof; with a strong acid to give a sulfide of the formula VII:

VII

followed by the steps defined in claim 2, to give the compound of the formula VI:

VI or a pharmaceutically acceptable salt thereof.

4. The process according to claim 3 wherein the strong acid is selected from sulfuric acid, hydrochloric acid, hydrofluoric acid, nitric acid and trifluoroacetic acid.

5. The process according to any of claims 3-4 wherein the dehydration of the alcohol of the formula VIII with a strong acid is conducted in solvent selected from toluene, xylene, hexanes and water.

6. The process according to any of claims 3-5 wherein the step of oxidizing the sulfide of the formula VII is conducted at less than 2 pH.

7. The process according to any of claims 1-6, in which Rl is -CH₃, R.2 is ■

CH₂CH₃, R3 is F and R4 is H.

8. The process according to any of claims 1-6, in which Rl is -CH₃, R2 is ■ CH₂CH₃, R3 is H and R4 is F.

9. A process according to claim 1 for preparing a compound of the formula VI:

VI wherein Rl, R², R³ and R⁴ are as defined in claim 1, and pharmaceutically acceptable salts thereof; which comprises oxidizing a sulfide of the formula VIII:

VIII

to give a compound of the formula X:

X

followed by dehydration of the compound of formula X to give a compound of formula IX

IX

followed by catalytic reduction of the compound of formula IX to give the compound of the formula VI:

VI

or a pharmaceutically acceptable salt thereof.

10. The process according to claim 9, in which Rl is -CH₃, R2 is -CH₂CH₃, R^ is F and R4 is H.

11. The process according to claim 9, in which Rl is -CH₃, R2 is -CH₂CH₃, R3 is H and R4 is F.

12. The process according to any of claims 1-11, wherein oxidizing a sulfide of the formula VII or formula VIII is carried out using a catalytic oxidizing agent and an oxidant.

13. The process according to claim 12 wherein the catalytic oxidizing agent is a tungsten, ruthenium, rhenium, molybdenum, osmium, silicotungstate or chromium oxidizing agent.

14. The process according to claim 13 wherein the catalytic oxidizing agent is a tungsten oxidizing agent such as e.g. sodium tungstate.

15. The process according to claim 14 wherein the oxidant is a peroxide.

16. The process according to claim 15 wherein the peroxide is sodium peroxide, hydrogen peroxide, sodium hypochlorite, sodium bromate, sodium periodate, peroxyacetic acid or peroxybenzoic acid.

17. The process according to any of claims 1-11, wherein oxidizing a sulfide of the formula VII or formula VIII is carried out using a stoichiometric oxidant.

18. The process according to claim 17 wherein the oxidant is a peroxide, oxone, MCPBA or KMnO₄.

19. The process according to any of claims 1-18 wherein the step of oxidizing the sulfide of the formula II is conducted at a temperature between 40⁰C and 60⁰C.

20. The process according to any of claims 1-19 wherein the catalytic reduction of the compound of the formula IX comprises catalytic hydrogenation with a palladium catalyst, a platinum catalyst or a ruthenium catalyst.

21. The process according to claim 20 wherein the catalytic reduction of the compound of the formula IX comprises catalytic hydrogenation with a palladium catalyst.

22. The process according to claim 20 wherein the catalytic reduction of the compound of the formula IX comprises catalytic hydrogenation with a palladium on carbon catalyst.

23. The process according to claim 22 wherein the catalytic reduction of the compound of the formula III comprises catalytic hydrogenation with a 10% palladium on carbon catalyst.

24. The process according to any of claims 20-23 wherein the step of catalytic reduction of the compound of the formula III is conducted in an aqueous solution with an alcohol.