WO2006037064A2 - Mutant polymerases for sequencing and genotyping - Google Patents

Abstract

The invention relates to the discovery of novel mutant DNA polymerases that possess altered kinetics for incorporating phosphate-labeled nucleotides during polymerization. The invention further relates to the use of these mutant DNA polymerases in sequencing and genotyping methods.

Description

MUTANT POLYMERASES FOR SEQUENCING AND GENOTYPING

INCORPORATION BY REFERENCE

[0001] This application claims the benefit of U.S. Patent Application No. 60/613,560, filed September 24, 2004, entitled "Composition and Method for Nucleic Acid Sequencing," and U.S. Patent Application No. 60/626,552, filed November 10, 2004, both of which are incorporated by reference herein, in their entirety and for all purposes.

GOVERNMENT RIGHTS

[0002] The invention described herein was made with support from U.S. government grants POl HG003015-01 0003 and R44 HG002292-02. Accordingly, the U.S. government may have certain rights in the invention.

FIELD OF THE INVENTION

[0003] The invention relates to the discovery of novel mutant DNA polymerases that possess altered kinetics for incorporating phosphate-labeled nucleotides during polymerization. The invention further relates to the use of these mutant DNA polymerases in sequencing and genotyping methods.

BACKGROUND OF THE INVENTION

[0004] The primary sequences of nucleic acids are crucial for understanding the function and control of genes and for applying many of the basic techniques of molecular biology. In fact, rapid DNA sequencing has taken on a more central role after the goal to elucidate the entire human genome has been achieved. DNA sequencing is an important tool in genomic analysis as well as other applications, such as genetic identification, forensic analysis, genetic counseling, medical diagnostics, and the like. With respect to the area of medical diagnostic sequencing, disorders, susceptibilities to disorders, and prognoses of disease conditions can be correlated with the presence of particular DNA sequences, or the degree of variation (or mutation) in DNA sequences, at one or more genetic loci. Examples of such phenomena include human leukocyte antigen (HLA) typing, cystic fibrosis, tumor progression and heterogeneity, p53 proto-oncogene mutations, and ras proto-oncogene mutations (see, Gyllensten et al, PCR Methods and Applications, 1:91-98 (1991); U.S. Patent No. 5,578,443, issued to Santamaria et al; and U.S. Patent No. 5,776,677, issued to Tsui et al). [0005] Various approaches to DNA sequencing exist. The dideoxy chain termination method serves as the basis for all currently available automated DNA sequencing machines, whereby labeled DNA elongation is randomly terminated within particular base groups through the incorporation of chain-terminating inhibitors (generally dideoxynucleoside triphosphates) and size-ordered by either slab gel electrophoresis or capillary electrophoresis (see, Sanger et al, Proc. Natl. Acad. ScL, 74:5463-5467 (1977); Church et al, Science, 240:185-188 (1988); Hunkapiller et al, Science, 254:59-67 (1991)). Other methods include the chemical degradation method (see, Maxam et al, Proc. Natl Acad. ScL, 74:560-564 (1977), whole-genome approaches (see, Fleischmann et al, Science, 269:496 (1995)), expressed sequence tag sequencing (see, Velculescu et al, Science, 270 (1995)), array methods based on sequencing by hybridization (see, Koster et al , Nature Biotechnology, 14:1123 (1996)), highly parallel pyrosequencing, and single molecule sequencing (SMS) (see, Jett et al, J. Biomol. Struct. Dyn. 7:301 (1989); Schecker et al, Proc. SPIE-Int. Soc. Opt. Eng. 2386:4 (1995)).

[0006] There have been several improvements in the dideoxy chain termination method since it was first reported in the mid-1980s with enhancements in the areas of separating technologies (both in hardware formats & electrophoresis media), fluorescence dye chemistry, polymerase engineering, and applications software. The emphasis on sequencing the human genome with a greatly accelerated timetable along with the introduction of capillary electrophoresis instrumentation that permitted more automation with respect to the fragment separation process allowed the required scale-up to occur without undue pressure to increase laboratory staffing. However, despite such enhancements, the reductions in the cost of delivering finished base sequence have been marginal, at best.

[0007] In general, present approaches to improve DNA sequencing technology have either involved: (1) a continued emphasis to enhance throughput while reducing costs via the dideoxy chain termination method; or (2) a paradigm shift away from the dideoxy chain termination method such as sequencing by a non-electrophoretic method.

[0008] Although several non-electrophoretic DNA sequencing methods have been demonstrated or proposed, all are limited by short read lengths. For example, matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, which separates DNA fragments by molecular weight, is only capable of determining about 50 nucleotides of DNA sequence due to fragmentation problems associated with ionization. Other non-electrophoretic sequencing methods depend on the cyclic addition of reagents to sequentially identify bases as they are either added or removed from the subject DNA. However, these procedures all suffer from the same problem as the classical Edman degradation method for protein sequencing, namely that synchronization among molecules decays with each cycle because of incomplete reaction at each step. As a result, current non-electrophoretic sequencing methods are unsuitable for sequencing longer portions of DNA.

[0009] The DNA polymerases employed in known sequencing methods are thermophilic or thermostable DNA polymerases such as Taq DNA polymerase derived from the bacterium Thermus aquaticus, Pfu DNA polymerase derived from the bacterium Pyrococcus furiosus, TIi DNA polymerase (also called Vent polymerase) derived from the bacterium

Thermococcus litoralis and others. Thermostable DNA polymerases also play a crucial role in current methods of DNA amplification and sequencing. Some improvements in these methods have been made in recent years, particularly in DNA sequencing and the polymerase chain reaction. There are a number of mutants that have been generated, for example, DNA polymerase mutants that lack exonuclease activity {e.g., Vent_R® (exo-) DNA polymerase and Deep Vent_R™ (exo-) DNA polymerase from New England Biolabs; Therminator™ DNA polymerase from New England Biolabs; and KOD Hifi™ DNA polymerase from Novagen).

[0010] One of the most important characteristics of thermostable polymerases is their error rate. Error rates are measured using different assays, and as a result, estimates of error rates may vary, particularly from one laboratory to another. Polymerases lacking 3'→ 5' exonuclease activity generally have higher error rates than polymerases with exonuclease activity. The total error rate of Taq polymerase has been variously reported between 1 x 10^"4 to 2 x 10^"5 errors per base pair. Pfu polymerase appears to have the lowest error rate at about 1.5 x 10^"6 error per base pair, and TIi polymerase is known to be intermediate between Taq and Pfu. Although error rate is a significant factor when choosing a DNA polymerase, it is not the only factor. Reliability, stability and catalytic rate of the enzyme are equally important.

[0011] Clearly, there is an untapped potential in genetically modified DNA polymerases, which could provide significant advantages over their natural counterparts that are used today. There is indeed a need for more effective and efficient enzymes that can be used in methods of non-electrophoretic DNA sequencing. The present invention satisfies this and other needs. BRIEF SUMMARY OF THE INVENTION

[0012] The present invention provides novel mutant DNA polymerases that possess altered kinetics for incorporating phosphate-labeled nucleotides during polymerization. One major advantage of the mutant polymerases of the present invention is their faster incorporation kinetics for phosphate-labeled deoxynucleotide-triphosphates (dNTPs) during polymerization of DNA strands in comparison to native DNA polymerases. Another advantage of the present invention is that the mutant DNA polymerases reduce the cost of sequencing and genotyping due to their altered kinetics (e.g., faster kinetics). As such, the mutant DNA polymerases can be employed in various methods, including single-molecule DNA sequencing and genotyping methods.

[0013] In one embodiment, the present invention provides a mutant DNA polymerase, wherein the amino acid sequence of the phosphate region of said mutant DNA polymerase comprises two or more mutations not present in the phosphate region of the most closely related native DNA polymerase, and wherein said two or more phosphate region mutations increase the rate at which said mutant DNA polymerase incorporates phosphate-labeled nucleotides. In a related embodiment, the mutant DNA polymerase, or at least the phosphate region of said mutant polymerase, is derived from a Family A or Family B polymerase. In yet another related embodiment, the mutant DNA polymerase is a chimera combining homologous regions from distinct polymerases (as described, e.g., by Wang et al., J. Biological Chemistry, 270:26558-26564 (1995); Villbrandt et al., Protein Engineering,

13:645-654 (2000); Boudsocq et al., J. Biological Chemistry, 279:32932-32940 (2004)). For example, the phosphate region of one polymerase could be swapped for the phosphate region of another polymerase to create a new chimera.

[0014] In another embodiment, the invention provides a mutant 9°N DNA polymerase, wherein the amino acid sequence of the phosphate region of the 9⁰N DNA polymerase comprises two or more mutations not present in the phosphate region of native 9⁰N DNA polymerase, and wherein the two or more phosphate region mutations increase the rate at which said mutant DNA polymerase incorporates phosphate-labeled nucleotides. In a related embodiment, the mutant 9⁰N DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to 9°N-A485L DNA polymerase (SEQ ID NO: 2), comprises an alanine to leucine mutation at amino acid position 485, and further comprises one or more additional mutations in its phosphate region. In yet another related embodiment, the one or more additional mutations are selected from the group consisting of a mutation at amino acid position 352, 355, 408, 460, 461, 464, 480, 483, 484, and 497, and combinations thereof. In another related embodiment, the mutant 9°N DNA polymerase comprises a mutation at amino acid position 484 as one of the additional mutations. In yet another related embodiment, the additional mutations include mutations at amino acid positions 408, 464, and 484. In some embodiments of the mutant 9°N DNA polymerase of the invention, the mutation at position 408 is selected from the group consisting of tryptophan, glutamine, histidine glutamic acid, methionine, asparagine, lysine, and alanine; the mutation at position 464 is selected from the group consisting of glutamic acid and proline; and the mutation at position 485 is tryptophan. In yet another related embodiment, the amino acids at positions 408, 464, and 484 in the mutant 9°N DNA polymerase are tryptophan, glutamic acid, and , tryptophan, respectively.

[0015] In another embodiment, the invention provides a mutant DNA polymerase comprising an amino acid sequence region homologous to amino acids 325 to 340 of SEQ ID NO: 2, wherein the region contains at least one mutation and wherein the mutant DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to a 9N- A485L DNA polymerase (SEQ ID NO:2). In a preferred embodiment, the at least one mutation is at an amino acid position selected from the group consisting of amino acid positions 329, 332, 333, 336 and 338. In another preferred embodiment, the mutant DNA polymerase comprises an insertion or a deletion of at least 1 amino acid in an amino acid sequence region homologous to amino acids 325 to 340 of SEQ ID NO:2. In a related embodiment, the at least one mutation is an insertion or a deletion of at least 10 amino acids. In yet another embodiment, the at least one mutation is an insertion of amino acids REAQLSEFFPT at position 329.

[0016] In yet another embodiment, the invention provides a mutant DNA polymerase comprising an amino acid sequence region homologous to amino acids 473 to 496 of SEQ ID NO: 2, wherein the region contains at least one mutation and wherein the mutant DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to 9N- A485L DNA polymerase (SEQ ID NO: 2). In a related embodiment, the at least one mutation is at an amino acid position selected from the group consisting of amino acid positions 480, 483, 484 and 485. In another preferred embodiment, the mutant DNA polymerase comprises an insertion or a deletion of at least 1 amino acid in an amino acid sequence region homologous to amino acids 473 to 496 of SEQ ID NO:2. In a related embodiment, the at least one mutation is an insertion or a deletion of at least 10 amino acids. In yet another embodiment, the at least one mutation in the DNA polymerase is an insertion at a position corresponding to position 485 in SEQ ID NO:2 of an amino acid sequence selected from the group consisting of PIKILANSYRQRW, TIKILANSYRQRQ and PIKILANLDYRQRL. In yet another embodiment, the mutant DNA polymerase comprises the mutated sequence of amino acids found at region 473 to 496 in any of the DNA polymerase sequences set forth in SEQ ID NO: 4 through SEQ ID NO: 750, and wherein the mutant DNA polymerase comprises the mutated sequence at a region which is homologous to region 473 to 496 in SEQ ID NO: 2.

[0017] In another embodiment, the invention provides a mutant DNA polymerase, wherein the mutant DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to 9N-A485L DNA polymerase (SEQ ID NO: 2), and comprises (i) a first amino acid sequence region homologous to amino acids 325 to 340 of SEQ ID NO:2, wherein this first region contains at least one mutation; and (ii) a second amino acid sequence region homologous to amino acids 473-496 of SEQ ID NO:2, wherein this second region contains at least one mutation. In a related embodiment, the at least one mutation in the first region is at an amino acid position selected from the group consisting of amino acid positions 329, 332, 333, 336 and 338, and the at least one mutation in the second region is at an amino acid position selected from the group consisting of amino acid positions 480, 483, 484 and 485. In certain embodiments, the mutations include insertions or deletions of one or more amino acids in the two regions, including insertions or deletions of up to ten or more amino acids. In one embodiment, the mutation in the first region is an insertion of amino acids REAQLSEFFPT at the position corresponding to position 329 in SEQ ID NO: 2 and the mutation in the second region is an insertion of PIKILANSYRQRW at the position corresponding to position 485 in SEQ ID NO: 2. In yet another embodiment, the first region in the mutant polymerase comprises the mutated sequence of amino acids found at region 325 to 340 in any of the DNA polymerase sequences set forth in SEQ ED NO: 4 through SEQ ID NO: 750, and the second region comprises the mutated sequence of amino acids found at region 473 to 496 in any of the DNA polymerase sequences set forth in SEQ ID NO: 4 through SEQ ID NO: 750.

[0018] The invention also provides a mutant 9°N DNA polymerase comprising at least two mutations in the phosphate region, including an A485L mutation, wherein the mutant 9°N DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to 9°N-A485L DNA polymerase (SEQ ID NO: 2), and wherein the increased rate is at least three times, at least seven times, at least twenty times, or at least fifty times faster than that catalyzed by 9°N-A485L DNA polymerase, as based on primer extension assays analyzed on polyacrylamide gels.

[0019] In yet another embodiment, the invention provides the mutant 9°N DNA polymerase of SEQ ID NO. 568. In a related embodiment, the invention provides the mutant 9⁰N DNA polymerase of SEQ ID NO. 568, where the mutant sequence further comprises one or more additional mutations and wherein the one or more additional mutations are selected from the group consisting of an alteration in amino acid identity, an insertion of one or more amino acids, and the deletion of one or more amino acids. In yet another related embodiment, the mutant 9°N DNA polymerase includes one mutation relative to SEQ ID NO. 568, wherein said additional mutation is in the phosphate region of the mutant 9°N DNA polymerase. In a related embodiment, the additionally mutated amino acid is selected from the group consisting of the asparagine at position 491 and lysine at position 487.

[0020] In another embodiment, the invention provides a mutant 9°N DNA polymerase of SEQ ID NO. 568 and conservative modifications thereof. Examples of conservative amino acid mutations are well-known in the art and described, e.g., in U.S. Patent set forth, for instance, in U.S. Pat. No. 5,364,934. In a related embodiment, the conservative mutations lie outside the phosphate region of said mutant polymerases.

[0021] The invention also provides a mutant 9⁰N DNA polymerase with an amino acid sequence selected from the group consisting of the even-numbered SEQ ID NOs 4 through 750. In a related embodiment, the invention provides a purified nucleic acid sequence encoding the amino sequence of any of the even-numbered SEQ ID NOs: 4 through 750. In a related embodiment, the invention provides a purified nucleic acid sequence encoding a polymerase represented by the group consisting of the even-numbered SEQ TD NOs: 4 through 750. In a related embodiment, the invention provides the nucleic acids of the odd- numbered SEQ ID NOs: 3-749.

[0022] The invention also provides a method for identifying polymerases with improved suitability for a nucleotide sequencing process, wherein the improved suitability is measured relative to that of a parent polymerase, comprising: (1) assaying the rate of phosphate-labeled nucleotide incorporation by a test mutant polymerase, wherein said phosphate region of said test polymerase is at least 90% identical to said parent polymerase; (2) determining if said rate of phosphate-labeled nucleotide incorporation by said test mutant polymerase is suitable for said nucleotide sequencing process; and, if said rate of phosphate-labeled nucleotide incorporation is suitable, then identifying the test mutant polymerase as such. In a related embodiment, the method includes an additional step, wherein if said rate of phosphate- labeled nucleotide incorporation is not suitable, steps (1) and (2) are repeated with a second test mutant polymerase until a suitable polymerase is identified, hi yet another related embodiment, if said second test mutant comprises each of the mutations in the previous test mutant polymerase, and further comprises at least one additional mutation relative to the previous test mutant polymerase.

[0023] In a related embodiment of the method for identifying suitable polymerases, the parent polymerase is a thermostable polymerase, hi yet another related embodiment, the amino acid sequence of said parent polymerase is at least 90% identical to the amino acid sequence of 9°N-A485L DNA polymerase (SEQ ID NO: 2). In yet another related embodiment, the amino acid sequence of said parent polymerase is at least 95% identical to the amino acid sequence of 9°N-A485L DNA polymerase (SEQ ID NO: 2). hi yet another related embodiment, the improved polymerase is a polymerase which incorporates between 1 and 20 phosphate-labeled nucleotides per second or, preferably, between 5 and 15 phosphate- labeled nucleotides per second. In yet another embodiment of the method, the sequencing process suitable for the improved polymerase is a field-switch polynucleotide sequencing process.

[0024] hi another embodiment, the invention provides a mutant DNA polymerase, wherein the amino acid sequence of the phosphate region of the mutant DNA polymerase comprises one or more mutations not present in the phosphate region of the most closely related native DNA polymerase, and wherein the one or more phosphate region mutations increase the rate at which the mutant DNA polymerase incorporates a phosphate-labeled nucleotide. In a related embodiment, the mutant DNA polymerase is a Family A DNA polymerase, hi yet another related embodiment, the mutant DNA polymerase is a mutant Klenow DNA polymerase.

[0025] hi another related embodiment, the invention provides a mutant Klenow polymerase which incorporates phosphate-labeled nucleotides at an increased rate relative to the Klenow DNA polymerase of SEQ ID NO: 752, wherein the mutant Klenow DNA polymerase comprises one or more phosphate region mutations, hi a related embodiment, the additional mutations are selected from the group consisting of a mutation at amino acid position 423 and 504, and combinations thereof. In yet another related embodiment of the mutant Klenow DNA polymerase, the amino acid at position 423 is mutated or, alternately, the amino acid at position 504 is mutated. In certain related embodiments, the amino acid at position 423 is lysine or glutamic acid, and the amino acid at position 504 is glycine. In yet another related embodiment, the mutant Klenow DNA polymerase incorporates phosphate-labeled nucleotides at a rate at least three times faster than the Klenow polymerase of SEQ ID NO: 752. In yet another related embodiment, the invention provides the mutant Klenow DNA polymerases of SEQ ID NO: 756, 758, or 764, as well as polymerases with conservative mutations or mutations which do not substantially alter the rate at which the mutant polymerase incorporates phosphate-labeled nucleotides. In yet another related embodiment, the invention provides purified nucleic acids encoding the mutant Klenow DNA polymerases of the invention.

[0026] In another embodiment, the invention provides a mutant DNA polymerase, wherein the amino acid sequence of the phosphate region of the mutant DNA polymerase comprises one or more mutations not present in the phosphate region of the most closely related native DNA polymerase, and wherein the one or more phosphate region mutations increase the rate at which the mutant DNA polymerase incorporates a phosphate-labeled nucleotide, wherein the mutant DNA polymerase is a mutant Taq DNA polymerase. In a related embodiment, the mutant Taq DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to the Taq DNA polymerase of SEQ ID NO: 766.

[0027] In a related embodiment, the mutant Taq mutations are selected from the group consisting of a mutation at amino acid positions 589, 617, 645, 691, 673, and 726, and combinations thereof. In a related embodiment, the amino acid at position 617 is isoleucine. In yet another related embodiment, the mutated amino acid at position 645 is selected from the group consisting of histidine, phenylalanine, lysine and tryptophan. In yet another releated embodiment, the amino acid at position 691 is tyrosine. In yet another related embodiment, the amino acid at position 693 is glycine. In yet another related embodiment, the amino acid at position 726 is serine. In yet another related embodiment, the amino acid at position 589 is aspartic acid and the amino acid at position 645 is histidine. In yet another related embodiment, the mutant Taq DNA polymerase of the invention incorporates phosphate-labeled nucleotides at a rate at least two times faster, or between five and fifteen times faster, than the Taq polymerase of SEQ ID NO: 766. In yet another embodiment, the invention provides the mutant Taq DNA polymerase of SEQ ID NO: 768, 770, 772, 774, 776, 778, 780, 782 or 784, as well as derivatives of these mutant Taq DNA polymerases with additional conservative mutations or mutations which do not substantially alter the rate at which the mutant polymerase incorporates phosphate-labeled nucleotides. In yet another related embodiment, the invention provides purified nucleic acids encoding the mutant Taq DNA polymerases of the invention.

[0028] The invention additionally provides a mutant DNA polymerase selected from the group consisting of the mutant DNA polymerases represented by the even-numbered sequences of SEQ ID NOs: 4-750, 754-764, and 768-784, as well as a mutant DNA polymerase wherein the phosphate region of said mutant DNA polymerase is identical to the phosphate region of a polymerase selected from the group consisting of the mutant DNA polymerases represented by the even-numbered sequences of SEQ ID NOs: 4-750, 754-764, and 768-784. In a related embodiment, the invention provides a mutant DNA polymerase selected from the group consisting of the mutant DNA polymerases represented by the even- numbered sequences of SEQ ID NOs: 4-750, wherein the mutant DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to the DNA polymerase of SEQ ID NO: 2. In another related embodiment, the invention provides a mutant DNA polymerase selected from the group consisting of the mutant DNA polymerases represented by the even-numbered sequences of SEQ ID NOs: 754-764, wherein the mutant DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to the DNA polymerase of SEQ ID NO: 752. In yet another related embodiment, the invention provides a mutant DNA polymerase selected from the group consisting of the mutant DNA polymerases represented by the even-numbered sequences of SEQ ID NOs: 768-784, wherein said mutant DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to the DNA polymerase of SEQ ID NO: 766.

[0029] In a preferred embodiment, the phosphate-labeled nucleotides incorporated by the mutant DNA polymerases of the invention are γ-phosphate-labeled nucleotides. In one embodiment, the polymerase incorporates phosphate-labeled nucleotides in which the label is a moiety capable of complexing with DNA. The DNA-complexing moiety may include intercalating dyes (e.g., Figure 6), major-groove binders, minor-groove binders and moieties capable of covalent crosslinking to DNA. In yet another embodiment, the polymerase incorporates phosphate-labeled nucleotides where the label is a single or double-stranded oligonucleotide, i.e., an oligoLabel. In one aspect, the oligoLabel is attached to the gamma phosphate of the nucleotide triphosphate through a linker. In related embodiments, the linker may be attached to the oligoLabel by non-covalent bonds (e.g., hydrophobic or electrostatic associations, as depicted in Figure 7) or covalent bonds (e.g., an amide bond, as depicted in Figure 8).

[0030] In yet another embodiment, the invention provides mutant DNA polymerases which substantially lack exonuclease activity. In still another embodiment, the mutant DNA polymerases provided by the invention are derived from a family B polymerase. In yet another embodiment, the mutant DNA polymerases provided by the invention are derived from a family A polymerase. In a preferred embodiment, the amino acid sequence of the mutant DNA polymerase is derived from the amino acid sequence of a polymerase selected from the group consisting of a 9°N DNA polymerase derived from Thermococcus species 9°N-7; a TH DNA polymerase derived from Thermococcus litoralis; a DNA polymerase derived from Pyrococcus species GB-D; a KODl DNA polymerase derived from Thermococcus kodakaraensis; a Taq DNA polymerase derived from Thermus aquaticus; a Phi-29 polymerase derived from Bacillus subtilis phage phi-29; and a polymerase I Klenow fragment derived by proteolysis from the bacterium Escherichia coli (Henningsen, K., PNAS, 65:168 (1970); Brutlag et al., BBRC, 37:982 (1969); Setlow et al, JBC 247:224 (1972); Setlow, P. and Romberg, A., JBC, 247:232 (1972)). The sequences of these native DNA polymerases are set forth in Table 6.

[0031] In another embodiment of the invention, any of the mutant DNA polymerases set forth in SEQ ID NO: 4 through SEQ ID NO: 750 (9°N mutants), SEQ ID 754-764 (Klenow mutants) or SEQ ID NO: 767 through SEQ ID NO: 784 (Taq mutants) can be used for DNA sequencing and/or genotyping. DNA sequencing methods include, but are not limited to, single-molecule sequencing, such as field-switch sequencing, charge-switch sequencing and/or electrokinetic sequencing. See, e.g., U.S. Patent Nos. 6,232,075; 6,306,607; and

6,762,048; see also U.S. Patent Nos. 6,936,702 and 6,869,764. Preferably, the mutant DNA polymerases are used in single-molecule sequencing or single-molecule genotyping. In another preferred embodiment, the mutant polymerases selected are those which exhibit increased rates of incorporation of phosphate-labeled nucleotides relative to, e.g., the parent polymerases whose amino sequences are provided by SEQ ID NO: 2, SEQ ED NO: 752 or SEQ ID NO: 756. [0032] The instant invention also provides improved sequencing and genotyping methods that employ the mutant DNA polymerases. Particularly, the invention contemplates a method of DNA sequencing, wherein the method comprises (i) immobilizing at least one complex comprising a target nucleic acid, a primer nucleic acid, and a mutant DNA polymerase onto a surface; (ii) contacting the surface with a plurality of charged particles comprising at least one type of phosphate-labeled nucleotide triphosphate (NTP) (e.g., γ-phosphate-labeled NTP) by applying an electric field; (iii) reversing the electric field to transport unbound charged particles away from the surface; and (iv) detecting the incorporation of a phosphate-labeled NTP into a single molecule of the primer nucleic acid. The mutant DNA polymerase employed in this method can preferably be any of the mutant DNA polymerases represented by the even-numbered sequences of SEQ ID NOs: 4-750, 754-764, and 768-784. The phosphate-labeled NTPs can be further labeled with polyethylene glycol (PEG). The incorporation of an NTP can be detected by a total internal reflection fluorescent microscope or other detection devices.

[0033] The method of DNA sequencing can employ immobilizing at least one complex including a target nucleic acid, a primer nucleic acid, and a mutant DNA polymerase onto a surface that is an indium-tin oxide (ITO) electrode coated by a permeation layer. Complexes can be immobilized onto the surface by covalent bonding, non-covalent bonding, ionic bonding or the like. The method of DNA sequencing can employ contacting the surface with a plurality of charged particles. The charged particles include, but are not limited to, nanoparticles, charged polymers (e.g., DNA), and combinations thereof. The charged particles can further comprise at least one dye. In addition, the nanoparticles can be silica- DNA nanoparticles. For example, electrokinetic DNA sequencing can be performed in a two-electrode chamber such as a microtiter plate fitted with two electrodes. One advantage of this method is that over two-hundred different single DNA molecules can be sequenced simultaneously in a single well at a maximum rate of about 10 to about 200 nucleotides per second per molecule and at read lengths of 20 kilobases (kb) or more. Another advantage of this method is the lower cost of sequencing as compared to other long read approaches due to the high degree of multiplexing and the substitution of microtiter plates for expensive micro- or nano-fabricated devices.

[0034] In an additional embodiment, the invention provides mutant polymerases wherein the mutant polymerases have one, two, or more anchor sequences for immobilizing the polymerases on a solid surface and/or associating the polymerase with a target nucleic acid, in order to increase the processivity index of the polymerase. DNA polymerases comprising such anchor sequences are described, e.g., in U.S. Patent Application 10/821,689 (published as 2005/0042633A1), incorporated herein by reference.

[0035] The invention further encompasses methods of DNA genotyping. Such methods can employ genotyping by sequencing specific DNA segments from the target genome or randomly-selected DNA segments from the target genome to identify a subset of the genetic variation. Alternatively, efficient sequencing via the methods of the present invention can provide information about a complete genotype (i.e., by sequencing the entire genome). Sequence analysis performed using the polymerases and/or methods of the present invention can provide reads up to 20 kilobases and longer. Such long reads, each originating from a single DNA molecule, allow determination of haplotypes and long-range genomic rearrangements that are generally difficult to obtain with known sequencing and genotyping methods.

[0036] Other objects, features, and advantages of the present invention will be apparent to one of skill in the art from the following detailed description and figures.

BRIEF DESCRIPTION OF THE DRAWINGS

[0037] The present invention is best understood when read in conjunction with the accompanying figures which serve to illustrate the various embodiments. It is understood, however, that the invention is not limited to the specific embodiments disclosed in the figures.

[0038] Figure 1 shows an alignment of amino acid sequences of five Family B DNA polymerases. Residues conserved between the various polymerases are shown in bold. Abbreviations: 9N_pol : 9°N DNA polymerase; Kodl_pol : DNA polymerase from Thermococcus kodakaraensis; PWO : DNA polymerase from Pyrococcus woesei; Pfu: DNA polymerase from bacterium Pyrococcus furiosus; Vent: Thermococcus litoralis DNA polymerase.

[0039] Figure 2 shows a nucleotide configuration in a method of the present invention in which dNTPs are attached to a nanoparticle by a linker to the γ-phosphate group. This sort of nucleotide is included within the definition of the term "phosphate-labeled nucleotide," a substrate of the mutant DNA polymerases described herein. [0040] Figure 3 shows an electrokinetic cycle in an electrokinetic sequencing method that employs the mutant DNA polymerases. Figure 3 A illustrates the accumulation of negatively- charged particles above immobilized polymerase-DNA complexes on a positively-charged indium-tin oxide (ITO) electrode. Figure 3B illustrates the movement of unbound particles away from the ITO electrode when the electric field is reversed. The ITO electrode surface is illuminated by total internal reflection (arrows) and the particles retained by the polymerase- DNA complexes are imaged.

[0041] Figure 4 (left) shows a diagram of a circular template that is permanently associated with an anchored mutant DNA polymerase of the present invention, while still being able to slide through the DNA binding groove to permit primer extension. The tunnel formed by polymerase immobilization is roughly the same dimension as a DNA sliding clamp. Figure 4 (right) shows the crystal structure of Therminator™ polymerase with 6xHis engineered loops inserted at positions K53 and K229. The open/closed conformational change involves movement of the helices O and N as shown to admit a nucleotide to the binding pocket. DNA ("ssDNA template") in the DNA binding cleft is also shown.

[0042] Figure 5 depicts the structure of dUTP-PEG8-P2-AlexaFluor633 (a 7-labeled NTP), a nucleotide triphosphate attached to a dye and linker by a nitrogen-phosphorous bond.

[0043] Figure 6 depicts a terminal phosphate-labeled nucleotide in which the label is an intercalating dye, JOJO-I, capable of complexing with DNA.

[0044] Figure 7 depicts an oligoLabel joined to a nucleotide, wherein the oligoLabel is attached to the nucleotide (dCTP) via non-covalent interactions with JOJO-I and a linker.

[0045] Figure 8 depicts a covalent crosslinked complex between psoralen and an oligoLabel.

[0046] Figure 9 depicts steps in the enzymatic pathway of DNA replication by polymerases. The action of a variety of DNA polymerases can be defined by a reaction pathway that describes the steps involved in the process of DNA replication. This pathway is typically presented in six steps as shown in Figure 9 {see, e.g., Joyce, CM. and Benkovic, S.J., Biochemistry, 43:14317-14324 (2004)). Step 1, binding of DNA by the polymerase; Step 2, binding of dNTP by the polymerase-DNA complex; Step 3, rearrangement of secondary structure elements from "open" (Eo) to "closed" (Ec) conformation (seen in most polymerases, but not all), followed by additional unspecified conformational changes and binding Of Mg²⁺ ions to form the active site (Steps 3.1 and 3.2); Step 4, phosphoryl transfer attaching the nucleotide to the DNA; Step 5, reversal of earlier conformational changes to restore the open conformation of the enzyme; and Step 6, release of pyrophosphate (PPi). In most polymerases studied, the rate-limiting step occurs between Steps 3 and 4 (Shah et al., J. Biol. Chem., 276:10824-10831 (2001); Arndt et al., Biochemistry, 40:5368-5375 (2001); Purohit et al., Biochemistry, 42:10200-10211 (2003); Fidalgo da Silva et al., J. Biol. Chem., 277:40640-40649 (2002); Rothwell et al., Molecular Cell, 19:345-355 (2005); Yang et al., Biophysical Journal, 86:3392-3408 (2004)).

[0047] Figure 10 shows the results of a gel extension assay using saturating amounts of the selected purified polymerases.

[0048] Figure 11 shows the analysis of the assay described in Figure 10, including the average rate (nucleotides per second) for each of the indicated enzymes.

[0049] Figure 12 shows steps in the identification of the phosphate region of 9°N DNA polymerase {see Example 3). Figure 12a shows 9°N DNA polymerase holoenzyme (lQHT.pdb) superposed with DNA and TTP from RB69 polymerase (HG9.pdb). Figure 12b shows amino acids selected from Figure 12a by proximity to dTTP (within 15A) and constrained by location between the gamma-phosphate of the dTTP and the enzyme surface. Figure 12c shows the secondary structural elements in 9N DNA polymerase containing amino acids identified in Figure 12b.

DETAILED DESCRIPTION OF THE INVENTION

I. Definitions

[0050] The following definitions are set forth to illustrate and define the meaning and scope of the various terms used to describe the invention herein. As such, the following terms have the meanings ascribed to them unless specified otherwise.

[0051] A "native DNA polymerase," as used herein, is used to describe DNA polymerases that have not previously been genetically altered or modified as described herein. Examples of native DNA polymerases include, but are not limited to, a 9°N DNA polymerase derived from Thermococcus species 9°N-7; a TIi DNA polymerase derived from Thermococcus litoralis; a DNA polymerase derived from Pyrococcus species GB-D; a KODl DNA polymerase derived from Thermococcus kodakaraensis; a native Taq DNA polymerase derived from Thermus aquaticus; a native Phi-29 polymerase derived from Bacillus subtilis phage phi-29; and a polymerase I Klenow fragment derived from the bacterium Escherichia coli . Sequences of representative native DNA polymerase sequences are provided in Table 6. Native DNA polymerases may be used as parent polymerases in methods of the invention which relate to the identification of mutant polymerases, derived from the parent polymerases, which exhibit altered and typically improved kinetics of incorporating phosphate-labeled nucleotides.

[0052] The term "mutant DNA polymerase" refers to any DNA polymerase that has been genetically altered such that it contains one or more mutation {e.g., point mutation(s), deletion(s), insertion(s) and the like) in its polypeptide sequence compared to a native DNA polymerase of the same species.

[0053] The term "altered kinetics" means that the rate of polymerization {i.e., the incorporation of nucleotides into a DNA strand) of a DNA polymerase has been changed {e.g., increased or decreased) as compared to the rate of polymerization displayed by a naturally occurring or native DNA polymerase, and includes effects on the reaction mechanism that impact nucleotide binding and incorporation of the nucleotide.

[0054] The term "homologous position" means, for the purpose of the specification and claims, an amino acid position in a genetically altered polypeptide sequence of a specific protein {e.g., a mutant DNA polymerase) that corresponds, or is similar in position or structure, to the amino acid position of the naturally occurring or native polypeptide sequence of the specific protein {e.g., a native DNA polymerase). For example, the genetically altered polypeptide sequence of a mutant DNA polymerase can exhibit a point mutation at amino acid position N, such that the amino acid at position N is changed from, e.g. , alanine in the native polymerase sequence, to leucine in the mutant polymerase sequence. Amino acid positions identified within this document are numbered according to the reference sequence for each polymerase type unless otherwise noted, with mutants of 9°N DNA polymerase numbered according to amino acid positions of SEQ ID NO. 2, mutants of Klenow DNA polymerase according to amino acid positions of SEQ ID NO. 752, and mutants of Taq DNA polymerase according to amino acid positions of SEQ ID NO. 766. A more specific example would be the phosphate regions of DNA polymerases which, when mutated, result in altered or improved kinetics of nucleotide incorporation. The phosphate region of a DNA polymerase is described in more detail below and in the Examples provided herein. Other specific homologous positions in 9N-A485L polymerase, Taq polymerase and Klenow polymerase are shown in Table 4, below.

Table 4

Homologous Residues in Various DNA Polymerases

[0055] The term "oligonucleotide" as used herein includes oligomers of nucleotides or analogs thereof, including deoxyribonucleosides, ribonucleosides, and the like. Typically, oligonucleotides range in size from a few monomelic units, e.g., 3-4, to several hundreds of monomelic units. Whenever an oligonucleotide is represented by a sequence of letters, it will be understood that the nucleotides are in 5'-3' order from left to right and that "A" denotes deoxyadenosine, "C" denotes deoxycytidine, "G" denotes deoxyguanosine, "T" denotes thymidine, and "U" denotes deoxyuridine unless otherwise noted.

[0056] The term "nucleotide" as used herein refers to a phosphate ester of a nucleoside, e.g., mono-, di-, tri-, terra-, penta-, polyphosphate esters, wherein the most common site of esterification is the hydroxyl group attached to the C-5 position of the pentose. Nucleosides also include, but are not limited to, synthetic nucleosides having modified base moieties and/or modified sugar moieties, e.g., described generally by Scheit, Nucleotide Analogs, John Wiley, N. Y. (1980). Suitable NTPs include both naturally occurring and synthetic nucleotide triphosphates, and are not limited to, ATP, dATP, CTP, dCTP, GTP, dGTP, TTP, dTTP,

UTP, and dUTP. Preferably, the nucleotide triphosphates used in the methods of the present invention are selected from the group consisting of dATP, dCTP, dGTP, dTTP, dUTP, and combinations thereof. Preferably, nucleotide triphosphates are used, however, other phosphates such as mono-, di-, terra-, penta-, and polyphosphate esters can also be used. [0057] The terms "phosphate-labeled nucleotide triphosphate (NTP)" and "phosphate- labeled deoxynucleotide-triphosphate (dNTP)" are used interchangeably herein, and refer to any nucleotide (i.e., natural or synthetic) that contains a detectable label on any of its phosphate positions. The label, e.g., a dye, can be attached to the dNTP by a linker. The label or linker can be attached to the phosphate atom by a phosphorus-oxygen, phosphorus- nitrogen, phosphorus-sulfur, or phosphorus-carbon bond, for example, dUTP-PEG8-P2- AlexaFluor633 (see Figure 5). The dNTP can also incorporate a polyethylene glycol (PEG) in addition to a dye label. For example, the dNTP can be a PEG-modified dNTP (e.g., dNTP with a PEG linker) with or without a dye label. One example of a phosphate-labeled nucleotide is a γ-labeled nucleotide. The term "γ-labeled" refers to a detectable label or an undetectable linker attached to any of the 3 phosphates on the nucleotide. The terms "γ- phosphate-labeled nucleotide triphosphate (NTP)" or "γ-phosphate-labeled deoxynucleotide- triphosphate (dNTP)" refer to any nucleotide (i.e., natural or synthetic) that contains a detectable label on its terminal, e.g., γ-phosphate, position. Preferably, nucleotide triphosphates are used, however other phosphates such as mono-, di-, tri, tetra-, penta-, and polyphosphate esters can also be used, wherein the label is preferably attached to the terminal phosphate, but may be attached to non-terminal phosphates. Certain labeled nucleotides suitable for use in the present invention include, but are not limited to, labeled nucleotides disclosed in for example, U.S. Patent Nos. 6,232,075, 6,306,607, 6,936,702, 6,869,764, U.S. Patent Publication No. US2005/0042633, U.S. Patent Application Nos. 11/118,031, filed

April 29, 2005, 11/154,419, filed June 15, 2005 and 60/648,091, filed January 28, 2005. All of the foregoing patent publications and applications are incorporated herein by reference in their entirety.

[0058] The term "primer nucleic acid" refers to a linear oligonucleotide, which specifically anneals to a unique target nucleic acid sequence and allows for synthesis of the complement of the target nucleic acid sequence.

[0059] The phrase "target nucleic acid" refers to a nucleic acid or polynucleotide whose sequence identity or ordering or location of nucleosides is to be determined using the methods described herein.

[0060] The phrase "sequencing a nucleic acid," in reference to a target nucleic acid, includes determination of partial as well as full sequence information of the target nucleic acid. That is, the term includes sequence comparisons, fingerprinting, and like levels of information about a target nucleic acid, as well as the express identification and ordering of nucleosides, usually each nucleoside, in a target nucleic acid. The term also includes the determination of the identification, ordering, and locations of one, two, or three of the four types of nucleotides within a target nucleic acid.

II. Phosphate Region

[0061] DNA polymerases are classified into 6 families: A, B, C, X, Y and RT (Braithwaite et al, Nucleic Acids Res, 21:787 (1993); Delbos et al., J Exp Med, 201:1191 (2005); Hubscher et al., Annu Rev Biochem, 71:133 (2002); Ito and Braithwaite, Nucleic Acids Res, 19:4045 (1991); L.S. Kaguni, Annu Rev Biochem, 73:293 (2004); Southworth et al., Proc Natl Acad Sci USA, 93:5281 (1996); T.A. Steitz, J5/o/ Chem, 274:17395 (1999)). Family A polymerases perform both replication and repair functions, and include enzymes like Taq DNA polymerase, E. coli DNA polymerase I, T7 DNA polymerase and mitochondrial polymerase gamma. Family B polymerases include replicases such as the archaeal polymerase 9⁰N, the bacteriophage polymerases RB69 and phi-29, and the eukaryotic replicases alpha, delta and epsilon. Family C polymerases include bacterial replicases such as E. coli DNA polymerase III. Family X polymerases, involved in error-prone repair, include polymerases beta, lambda, mu, DP04 and terminal transferases. Finally, Family Y polymerases are the so-called lesion-bypass polymerases; they include polymerases eta, kappa, iota, and zeta. Polymerases within each family are structurally related. Structural models have been determined by x-ray crystallography for members of nearly every family.

[0062] The term "phosphate region" as used herein refers to a collection of secondary structure elements (i.e., helix, strand, coil) in a DNA polymerase which form a protein channel connecting, e.g., the γ-phosphate of a bound dNTP to the enzyme surface. As such, this channel would be occupied by a linker attached to the dNTP gamma-phosphate extending toward the enzyme surface. In one aspect of the invention described herein, DNA polymerases comprising phosphate region mutations exhibit improved utilization of phosphate-labeled dNTPs. Identification of the phosphate region of a particular polymerase is based on protein structures, which may be obtained from published databases of known structures, by x-ray crystallography, or by structural alignment to known structures.

[0063] A description of the method used to identify the phosphate region of DNA polymerases is provided in Example 3. The amino acid residues which comprise the phosphate regions of several specific DNA polymerases are listed in Table 5, below. The single-letter amino acid code and residue numbers are used to identify the regions. Letters next to the various listed regions indicate whether the secondary structure in that region is a part of a random coil (c), an α-helix (h), or β strand (s).

TABLE 5

9N (RB69DNA)* Taq Pol Beta Pol Eta I HIV-RT

(1QHT.PDB) (1QTM.PDB) (2BPF. PDB) (UIH. PDB) (1 RTD.PDB)

C Y261-V263 S G603-S612 C E147-R149 S : 25-M31 C K1-V10 h I264-T267 C Q613 S I150-R152 C N32-A33 C P14-T27

C I268-T274 h I614-L622 h E153-K168 h F34-C43 h E28-E44

C E325-F327 C S623-D625 C G179-A185 S S58-S63 C G45 h P328-I337 h E626-E634 S E186-S188 h Y64-K68 S K46-S48 h L341-V344 C G635-D637 C T273-S275 C Y69-T76 C K49-T58

C S345-S347 h I638-F647 h D276-K289 h I77-K83 S P59-K65 h S348-K363 C G648-D655 C E309-E316 C C84-L87 C K66-T69 h S407-T415 h P656-Y671 h Q317-I232 h K268-N276 S K70-D76 h F448-K468 h A675-L682 C Q324-E335 C Y277-D281 C G112-S117 h P473-L489 h Y686-Q698 S A282-V286 S V118-K126

C A490-G498 C S699-P701 C C297-E310 C Y127-A129 h A553-N568 h K702-R717 S F130-1132

C P569-L577 h A796-G809 C P133-G141

S E578-V589 C V810-L817 S K142-L149

S E818-W827 h I195-R211

C W212-P226

"Amino acid numbering references the indicated protein database files.

III. Native DNA Polymerases

[0064] Thermophilic DNA polymerases, like other DNA polymerases, catalyze template- directed synthesis of DNA from nucleotide triphosphates (NTPs). A primer having a free 3' hydroxyl is required to initiate the synthesis of the DNA strand. The DNA polymerases also require divalent metal ions to function. Native thermophilic DNA polymerases have maximal catalytic activity at about 70⁰C to about 8O⁰C. At lower temperatures their activity is reduced. For example, at 37⁰C, many DNA polymerases have only about 10% of their maximal activity. DNA polymerases lacking 3'→ 5' proofreading exonuclease activity have higher error rates than the polymerases with exonuclease activity. Table 6 depicts the nucleic acid and amino acid sequences of several exemplary native and/or wild-type DNA polymerases. [0065] Taq DNA polymerase is a highly thermostable DNA polymerase of the thermophilic bacterium Thermus aquaticus. Taq DNA Polymerase catalyzes 5'=>3' synthesis of DNA. The enzyme has no detectable 3'=>5' proofreading exonuclease activity, and possesses low 5'=>3' exonuclease activity. Native Taq DNA Polymerase is preferred for amplifications of bacterial DNA sequences homologous to those found in E.coli. The error rate of Taq polymerase is between about 1 x 10^"4 to 2 x 10^"5 errors per incorporated base.

[0066] Pfu DNA polymerases is derived from the bacterium Pyrococcus furiosus and has the lowest error rate of thermophilic DNA polymerases. Its error rate is about 1.5 x 10^"6 per base pair. Besides that, Pfu DNA polymerase is highly thermostable and possesses 3' to 5\ exonuclease proofreading activity that enables the polymerase to correct nucleotide- misincorporation errors.

[0067] The native 9°N DNA polymerase is purified from a strain of E.coli that carries a modified 9°N DNA Polymerase gene {see Southworth et al. (1996) Proc. Natl. Acad. Sd. USA 93:5281-5285) from the extremely thermophilic marine archaea Thermococcus species, strain 9°N-7. The archaea is isolated from a submarine thermal vent, at a depth of 2,500 meters, 9° north of the equator at the East Pacific Rise. The native 9⁰N DNA polymerase has 3'→ 5' proofreading exonuclease activity. A 9⁰N DNA polymerase sequence is provided in Table 6.

[0068] The native TIi DNA polymerase {see Table 6) is derived from the hyperthermophile archaea Thermococcus litoralis. This polymerase (also referred to as Vent® DNA polymerase) is extremely thermostable and contains a 3'→ 5' exonuclease activity that enhances the fidelity of replication. The extension rate of this enzyme is in the order of 1000 nucleotides per min. In addition, the synthesis by the polymerase is largely distributive, which can generate products of at least 10,000 bases. A two-amino acid substitution within the conserved exonuclease domain abolishes both double and single strand-dependent exonuclease activity, without altering kinetic parameters for polymerization on a primed single-stranded template (see Kong et al. (1993) J Biol Chem. 25;268(3): 1965-75).

[0069] Another extremely thermostable native DNA polymerase (also known as Deep Vent® DNA polymerase) {see Table 6) is purified from a strain of E. coli that carries the Deep Vent DNA polymerase gene from Pyrococcus species GB-D (see Xu et al. (1993) Cell 75:1371-1377). The native organism is isolated from a submarine thermal vent at 2010 meters (see Jannasch et al (1992) Appl. Environ. Microbiol. 58:3472-3481) and is able to grow at temperatures as high as 104°C.

[0070] The native KODl DNA polymerase {see Table 6) is derived from the archaeon Thermococcus kodakaraensis, strain KODl. This DNA polymerase contains a 3'→ 5' exonuclease activity and two in-frame intervening sequences of 1,080 bp (360 amino acids; KOD polymerase intein-1) and 1,611 bp (537 amino acids; KOD polymerase intein-2), which are located in the middle of regions conserved among eukaryotic and archaeal alpha-like DNA polymerases. The KODl DNA polymerase exhibits an extension rate (100 to 130 nucleotides per second) which is 5 times higher than that of Pfu DNA polymerase. Further, KOD l's processivity (persistence of sequential nucleotide polymerization) is 10 to 15 times higher than that of Pfu DNA polymerase (see Takagi et al (1997) Appl. Environ. Microbiol 63(11): 4504-4510).

[0071] Those of skill in the art will recognize that other DNA polymerases will represent polymerase sequences which are suitable for modification according to the methods and principles described herein. For example, E. coli Klenow polymerase and phi29 DNA polymerase {see Table 6) are two non-thermostable Family B polymerases which may be mutated to alter their kinetics of nucleotide incorporation.

IV. The Mutant DNA Polymerases

[0072] The instant invention provides novel and active mutant DNA polymerases that possess altered kinetics for incorporating phosphate-labeled nucleotides during polymerization. Some of the mutants substantially lack exonuclease activity. As such, the mutant polymerases exhibit a faster or slower incorporation kinetics for deoxynucleotide- triphosphates (dNTPs) or phosphate-labeled deoxynucleotide-triphosphate (dNTP) during polymerization of DNA strands in comparison to native DNA polymerases, depending on the method used. In a preferred embodiment, the mutant polymerases are used for single- molecule sequencing or genotyping and exhibit incorporation kinetics that differ from the kinetics of polymerases which lack the mutations, hi another preferred embodiment, the mutant DNA polymerases of the instant invention contain one or more mutation(s) {e.g., point mutations) in their polypeptide sequence. The mutant DNA polymerases are derived from wild-type polymerases or so-called native polymerases, such as those described herein.

[0073] Table 7 lists, in alternating fashion, the nucleic acid and amino acid sequences of more than 300 mutant DNA polymerases (SEQ ID NOs: 1-750) derived from a 9°N DNA polymerase, referred to herein as 9°N-A485L polymerase (SEQ ID NO: 2). 9°N -A485L polymerase is identical to the 9°N-Native polymerase (SEQ ID NO: 786) except that the native polymerase includes an alanine ("A") residue at amino acid position 485, where the polymerase of SEQ ID NO:2 includes a leucine. The odd-numbered SEQ IDs in Table 7 are nucleic acid sequences and each nucleic acid sequence is followed immediately by the amino acid sequence of the mutant DNA polymerase it encodes. For example, the 9°N-A485L amino acid sequence encoded by SEQ ID NO: 1 is described by SEQ ID NO: 2, and includes a mutation at amino acid position 485, wherein the alanine (A) at position 485 in the native 9°N sequence has been changed to leucine (L). SEQ ID NO: 4 comprises the A=>L mutation at position 485, as well as an additional mutation at position 336, where the leucine (L) at position 336 in 9N-A485L has been changed to an arginine (R).

[0074] Some of the mutant DNA polymerase sequences provided herein comprise histidine tags for facilitating their purification. Where SEQ ID NOs. of polymerases comprising a histidine tag are referred to, the polymerase sequences are intended to include the sequence of the isolated polymerase without the histidine tags, as well as polymerases with the histidine tags attached.

[0075] Mutant polymerases can also contain inserted or deleted sequences when compared to the sequences of the polymerase(s) in the organisms from which they are derived. For example, SEQ ID NO: 56 includes the inserted sequence, REAQLSEFFPT, at position 329 of 9°N-A485L, and another insert, PIKILANSYRQRW, at position 485 of 9°N-A485L. Mutant DNA polymerases lacking exonuclease activity, such as the mutant 9N polymerases in Table 1, may contain 2 additional mutations at positions 141 and 143, wherein aspartic acid (D) and glutamic acid (E) are replaced with alanine (A).

[0076] Table 1 present a summary of the positions and identity of amino acid point mutations and inserts in over several hundred different mutant 9N DNA polymerases. The location of mutated amino acid residues in the polymerases of Table 1 are indicated by reference to the sequence of 9N-A485L, which differs from the 9°N-Native sequence at one position (A485). A change in amino acid sequence relative to 9°N-A485L is indicated in Table 1 by the appearance in a column cell of a letter corresponding to the amino acid which appears at the indicated position (residue positions relative to 9°N-A485L are indicated in the top row of each column). A dash ("-") in a cell in Table 1 indicates that the identity of the amino acid at the position indicated in the column header is unchanged relative to the identity of the amino acid at the same or homologous position in 9N-A485L. Similarly, the amino acid positions of mutant polymerases 4-750 in Table 1 which are not set forth in the column headings are identical to those in the same or homologous positions in 9N-A485L.

[0077] DNA polymerases can be classified into families based on segmental amino acid sequence similarities (Ito et al. (1991) Nucleic Acids Research 19:4045-4057). Homologous regions can be identified within and between polymerase families using both sequence and structural alignments (Joyce et al (1995) Journal of Bacteriology 177(22):6321-6329). Such alignments permit the identification of corresponding amino acid positions between polymerases, both within the same polymerase family and between families. A comparison and alignment of three-dimensional structures allows for the identification of structurally homologous regions across polymerase families, and can be used apart or in conjunction with sequence alignments. As an example, Figure 1 shows an alignment of the amino acid sequence of various family B DNA polymerases suitable for modification according to the methods and principles described herein.

[0078] The mutant DNA polymerases can be derived from various native parent enzymes, including, but are not limited to, native 9⁰N DNA polymerase derived from Thermococcus species 9°N-7; native TIi DNA polymerase derived from Thermococcus litoralis; native DNA polymerase derived from Pyrococcus species GB-D; native KODl DNA polymerase derived from Thermococcus kodakaraensis; native Taq DNA polymerase derived from Thermus aquaticus; native Phi-29 polymerase derived from Bacillus subtilis phage phi-29; and polymerase I Klenow fragment derived from the bacterium Escherichia coli.

[0079] During DNA synthesis, DNA polymerase binds to a template primer and the appropriate dNTP binds with the polymerase-DNA complex. A nucleophilic attack results in phosphodiester bond formation and release of pyrophosphate (PPi). Generally, DNA binding and nucleotide binding occur rapidly. The rate-limiting step is either phosphodiester bond formation or a conformational change that precedes nucleotide incorporation. In order for nucleotides to be incorporated, it requires a dynamic interaction between the polymerase with its nucleic acid and dNTP substrates (Figure 9). Polymerases undergo conformational changes during the DNA binding step; after the dNTP binding step and prior to chemical catalysis; after nucleotide incorporation during PPi release; and during translocation towards the new primer 3'-OH terminus {see, e.g., Patel et al. (2001) J. MoI. Biol. 308:823-837). [0080] Polymerization involves the association of the DNA polymerase with the template primer. According to polymerase crystal structure comparisons, the thumb subdomain of the polymerase wraps around the DNA. More specifically, the thumb subdomain rotates towards the palm subdomain, and the conserved amino acid residues located within the tip of the thumb domain rotate in the opposite direction relative to the rest of the thumb such that the tip is in proximity to the DNA. These changes result in an approximately 30 angstrom (A) wide cylinder that almost completely engulfs the DNA and the conserved amino acid residues within the tip of the thumb subdomain grip the DNA along the minor groove. The polymerase interacts primarily with the sugar-phosphate DNA backbone along the minor groove. These interactions are associated with bending of the DNA such that it adopts an S- shaped conformation. Another conformation change occurs during dNTP binding, wherein three steps are important to achieve the "induced- fit" model for nucleotide incorporation. In the first step, structural elements within the finger domain rotate toward the 3' primer terminus, resulting in a "closed" structure. In the second step, the template base rotates back into the helix axis by greater than or equal to 90°. hi the third step, the base portion of the incoming nucleotide forms a Watson-Crick base-pair with the template base, and the triphosphate portion forms metal-mediated ionic interactions with amino acid residues of the active site. The induced-fit model for nucleotide incorporation can explain how the following three interactions with the incoming nucleotides are formed during dNTP binding, namely, there is hydrogen bonding with the template base; there are stacking interactions with planar ringed amino acid residues; and there are electrostatic interactions with negatively charged phosphate groups and charged side-chains. Thus, the induced fit model appears to allow establishment of stacking interactions and also appears to serve to bring the dNTP Di¬ phosphate close to the primer 3'-OH group, thereby promoting metal-catalyzed transfer of a nucleotide monophosphate from the dNTP to the 3'-end of the primer strand. This induced-fit mechanism for nucleotide selection also appears to restrict conformations and structures of the incoming nucleotides, promoting efficient and correct nucleotide incorporation (Patel et al, supra).

V. A Mutant DNA Polymerase Assay

[0081] An assay system has been established for identifying the mutant DNA polymerases of the instant invention. For example, a candidate mutant DNA polymerase can be tested in a primer extension assay to determine the nucleotide incorporation rate of the mutant polymerase. Briefly, this system utilizes an oligonucleotide template, a 5'- fluorescent dye labeled oligonucleotide primer, and γ-phosphate PEG-labeled dNTPs. A mutant DNA polymerase is added to the reaction mixture and the sample is incubated at 74°C for a fixed time {e.g., 30 sec). The reaction is stopped by adding EDTA and the average number of bases added to the primer is determined by quantifying bands on a fluorescence-based electrophoresis instrument {e.g., LI-COR 4200). This analysis provides the average nucleotide incorporation rate (nt /sec). Kinetic constants are determined by measuring incorporation rate as a function of nucleotide concentration as previously described (Kong, H. et al., J. Biol. Chem., 268(3): 1965-75 (1993)). An alternative primer extension assay, especially useful for high-throughput screening, is also disclosed herein. Mutant DNA polymerases that extend the primer faster than the native parent polymerases are selected.

[0082] Another system useful for testing DNA polymerase properties and kinetics is disclosed in U.S. Patent No. 5,352,778, which describes an assay wherein polymerase activity is measured by the incorporation of radioactively labeled deoxynucleotides into DNAse- treated-, or activated DNA. Following subsequent separation of the unincorporated deoxynucleotides from the DNA substrate, polymerase activity is proportional to the amount of radioactivity in the acid-insoluble fraction comprising the DNA (for a detailed description see also Lehman et al. (1958) J Biol. Chem., 233:163).

VI. Overview of Electrokinetic Sequencing

[0083] Nanoparticle Nucleotides. The mutant DNA polymerases of the instant invention can be used in electrokinetic sequencing which, in one embodiment, is based on a nucleotide configuration in which nucleotide triphosphates (NTPs) such as deoxyribonucleotide triphosphates (dNTPs) are attached to nanoparticles by a linker (Figure 2). In one embodiment, the γ-phosphate group of the NTP can be tethered via a free-jointed linker to the surface of the nanoparticle. hi a preferred embodiment, the free-jointed linker is a polyethylene glycol (PEG) linker, hi certain instances, up to about 100 NTPs {e.g., dNTPs) cover the surface of a nanoparticle {e.g., 55 nm particle). Exceptionally bright fluorescence from these nanoparticles enables a charged-couple device (CCD) camera to image from about 200-300 single DNA molecules simultaneously with millisecond exposure times. In addition to improved detectability, the nanoparticles are also capable of carrying a substantial electric charge. Both characteristics, i.e., strong fluorescence and electric charge, are elements of electrokinetic sequencing methods. [0084] Electrokinetic Cycle. In certain aspects, electrokinetic sequencing methods of the present invention comprises cycled transport of nanoparticle nucleotides between a bottom electrode and a top electrode (Figure 2). In one embodiment, the bottom electrode is the glass bottom of a microtiter well coated with electrically-conductive, optically-transparent indium-tin oxide (ITO). About 200-300 single, individual, optically resolved polymerase- DNA complexes are immobilized in the field of view at random positions on the bottom of the well, such that the majority of complexes are optically resolvable from their nearest neighbors. This allows about 200-300 different molecules to be sequenced simultaneously by imaging a 100 μm field with a CCD camera.

[0085] In certain preferred aspects, the sequencing cycle comprises a wave of particles, which is cycled between electrodes by an alternating electric field (E-field). First, particles are concentrated in a monolayer at the bottom electrode to blanket the immobilized polymerase-DNA complexes. This allows polymerases to bind the correct nucleotides for incorporation into DNA. Next, the E-field is reversed to transport unbound particles away from the surface, leaving only particles retained by the polymerases. With unbound particles now cleared from the surface (e.g., an 800 nm distance is sufficient), retained particles are imaged by evanescent wave excitation with millisecond time resolution while the catalytic reaction is in progress. Images are acquired before the catalytic reaction is completed because, after incorporation of the nucleotide into DNA, pyrophosphate and the attached nanoparticle are released from the enzyme. This completes one sequencing cycle. The timing of E-field switching and image acquisition is dictated by the duration of the catalytic cycle, and is expected to range from about 1-100 msec (Levene et al, Science, 299:682 (2003)).

[0086] Throughput. In one embodiment, when the electrokinetic cycle operates at 10 cycles/sec (i.e., 100 msec period), the maximum possible sequencing speed (or catalytic rate) is 10 bases per second. At this speed, a 20 kb DNA molecule can be sequenced in 33 min with any mutant DNA polymerase of the instant invention. In addition, net throughput can be significantly enhanced by multiplexing. For example, with an average of one polymerase- DNA complex per 50 μm² area, there are about 200 optically-resolved complexes in the optical field (100 x 100 μm) in the bottom of the microtiter well. In this embodiment, each well is used only once for a period of 33 min. to simultaneously sequence all 200 20 kb DNA molecules (i.e., 4 million bases total). Then, the next 4 million bases can be sequenced in a new well, and so on. Although it would take about 30-40 days to process one 1536 well plate, one well at a time, the plate can be processed 4 times faster (i.e., in 7-10 days) by quadruplexing the instrument optics. Under these conditions, a 1536 well micro titer plate can produce the equivalent of 2 human genomes worth of sequence (i.e., 4 million bases/well x 1536 wells = 6.1 billion bases total).

VII. Methods for Long-Read Single Molecule Sequencing

[0087] Methods for long-read sequencing that employ the mutant DNA polymerases of the instant invention generally fall into two categories, depending on whether fluorescence or electrical detection is used. Fluorescence methods monitor either nucleotide addition by polymerase or exonucleo lytic hydrolysis of prelabeled DNA. Polymerase long-read methods use phosphate-labeled nucleotides that are released after base incorporation.

[0088] Electrokinetic sequencing is an example of a single molecule sequencing method. This method utilizes dNTPs modified with a dye label on the phosphate. The labeled phosphate released after base addition allows the label to be detected before, during or after separation from unused nucleotides in a microfluidics system.

[0089] The use of 50 nm zero-mode waveguides (i.e., 50 nm diameter apertures in a metal film) for near- field detection of phosphate-labeled nucleotides bound to mutant polymerases of the instant invention during the catalytic cycle is another example of a single molecule sequencing method (see also Levene et al, Science, 299:682 (2003)). The waveguide allows the enzyme to be detected in a small volume without interference from labeled nucleotides in bulk solution. High-throughput sequencing (i.e., imaging of 200-300 polymerases simultaneously with a CCD camera) is advantageously provided by the electrokinetic sequencing methods described herein.

[0090] A third method for single molecule sequencing involves labeling the mutant DNA polymerase with a fluorophore and detecting modulation of the fluorescence signal by fluorescence resonance energy transfer (FRET) as phosphate-labeled nucleotides, labeled with quenchers or other fluorophores, transiently bind to the enzyme. Background signal from nucleotides in the bulk medium is reduced by detecting modulation of the enzyme fluorescence, instead of directly detecting the nucleotide label. Herein, the polymerase is exposed to continuous illumination.

[0091] Non-fluorescent sequencing methods propose to detect electric signals from individual bases as a DNA strand traverses through a nanopore (Deamer et al, Ace. Chem. Res., 35:817 (2002)) and can be employed with the mutant DNA polymerases of the instant invention.

[0092] The electrokinetic sequencing method that employs the mutant DNA polymerases of the present invention overcomes the limitations and challenges of other single molecule sequencing methods. In addition, the mutant DNA polymerases, such as those described in Tables 1-3 which exhibit increased rates of phosphate labeled nucleotide incorporation, are suitable for use in the immobilized polymerase-DNA complexes described herein. As such, electrokinetic sequencing provides long-read high-throughput sequencing with sufficient resolution and without the need to label the polymerase. , , , ,

VIII. Topologically Linked Polymerase-DNA Complexes

[0093] In a preferred embodiment, the polymerase-DNA complexes are taught and described in U.S. Patent Publication No. 2005/0042633, published February 24, 2005, and incorporated herein by reference. As described therein, a polymerase-nucleic acid complex (PNAC), comprises: a target nucleic acid and a nucleic acid polymerase, wherein the polymerase has an attachment complex comprising at least one anchor, which at least one anchor irreversibly associates the target nucleic acid with the polymerase to increase the processivity index. As used herein, the term "processivity index" means the number of nucleotides incorporated before the polymerase dissociates from the DNA. Processivity refers to the ability of the enzyme to catalyze many different reactions without releasing its substrate. That is, the number of phosphodi ester bonds formed is greatly increased as the substrate is associated with polymerase via an anchor.

[0094] In a preferred embodiment, the polymerase is attached to the ITO permeation layer and stably associated with a DNA template to achieve long sequence reads. The polymerase can be attached to the ITO permeation layer via various linkages including, but not limited to, covalent, ionic, hydrogen bonding, Van der Waals' forces, and mechanical bonding.

Preferably, the linkage is a strong non-covalent interaction (e.g. avidin-biotin) or is covalent. In order to permanently associate the DNA template and the polymerase to the ITO permeation layer, an approach that functionally mimics the sliding clamp of a replisome, as described in Shamoo et al, Cell, 99:155 (1999), can be used.

[0095] As shown in Figure 3, the polymerase-DNA complex is covalently attached (i.e., anchored) to the ITO permeation layer through two linkers in order to irreversibly capture the DNA while still allowing it to slide through the polymerase active site. Circular in form, the DNA (-20 kb) is topologically linked to the immobilized polymerase, and therefore does not dissociate.

[0096] The methods of the present invention employ a mutant DNA polymerase such as a mutant DNA polymerase I, II, or III. Preferably, the methods employ a mutant DNA polymerase derived from family B polymerases. Suitable family B polymerases include, but are not limited to, a 9°N DNA polymerase derived from Thermococcus species 9°N-7; a TIi DNA polymerase derived from Thermococcus litoralis; a DNA polymerase derived from Pyrococcus species GB-D; a KODl DNA polymerase derived from Thermococcus kodakaraensis; a Taq DNA polymerase derived from Thermus aquaticus; a Phi-29 polymerase derived from Bacillus subtilis phage phi-29; and a polymerase I Klenow fragment derived from the bacterium Escherichia coli. Specific examples include, but are not limited to, any of the mutant DNA polymerases set forth in SEQ ID NO: 4 through SEQ ID NO: 750 (9°N mutants), SEQ ID 754-764 (Klenow mutants) or SEQ ID NO: 767 through SEQ ID NO: 784. Those of skill in the art will know of other enzymes or polymerases suitable for use in the present invention.

[0097] Examples of modified DNA polymerases that can be used with the methods of the instant invention are mutants derived from 9N-A485L (SEQ ID NO: 2; commercially available as Therminator™ (New England Biolabs, Inc)), including those listed in Table 1. The protein regions on either side of the DNA binding cleft of 9N-A485L, likely to be conformationally rigid, were identified based upon previous studies with RB69 polymerase. Loops of ten amino acids containing a 6xHis sequence at five candidate positions were inserted. Loops inserted at positions K53 and K229 of 9N-A485L (modeled in Figure 4) had no measurable effect on polymerase activity when present either individually or combined, and both were capable of binding Ni-NTA beads in an affinity purification procedure. Based upon previous studies ^"on active immobilized polymerases and other enzymes, e.g., unoriented T7 DNA polymerase (Levene et ah, Science, 299:682 (2003)), oriented EcoRI (Bircakova et al., J. MoI. Recognit., 9:683 (1996)), and solid-phase enzymes used in bioprocess engineering (Berg et al, In "Interfacial Enzyme Kinetics " John Wiley & Sons (2002)), the engineered polymerase is expected to display activity on a surface. Alternatively, non-covalent bonding is employed for attaching the polymerase via the 6xHis loops to a Ni-NT A-activated permeation layer. [0098] Suitable covalent coupling methods include, without limitation, a maleimide or thiol-activated permeation layer coupled to specific cysteine amino acids on the polymerase surface, a carboxylate permeation layer coupled to specific lysine amino acids on the polymerase surface, a hydrazine permeation layer coupled to the unnatural amino acid p- acetyl-L-phenylalanine on the polymerase surface, and the like. The latter is particularly interesting because of its high coupling specificity, long reactant shelf life, and imminent commercialization (Wang et ah, PNAS, 100:56 (2003)). Given a suitable coupling chemistry, complexes can be formed by mixing the 9N-A485L polymerase with primed circular DNA and driving them electrically to the electrode surface for covalent coupling. To ensure that most anchored 9N-A485L proteins are associated with template, DNA is used at concentrations exceeding the binding constant (Km_DNA = 5OpM for 9N; New England Biolabs Catalog). Polymerases anchored without DNA are neglected because they have no sequencing activity. When polymerase attachment is complete, the electric field is reversed to elute linear {e.g., broken) DNA templates, such that the only anchored polymerases capable of generating sequence data are those complexed with circular DNA templates. A simple computer model indicates that 200-300 polymerase-DNA complexes can be dispersed randomly in a 100 μm field of view at optically resolvable distances. The number of resolvable complexes decreases at higher densities because of overcrowding. Random dispersion on an inexpensive ITO surface provides an easy way to isolate single molecules for multiplexed, long-read sequence analysis. In another embodiment, polymerases are allowed to bind non-specifically to the ITO surface, rather than binding by specific anchors. Some of the polymerases will bind in an inactive orientation, and others will bind in an active orientation. Particularly, only those bound in an active orientation will produce signals from the sequencing reaction, while those bound in an inactive orientation will not produce signals and will therefore be undetectable.

IX. Examples

[0099] The following examples are offered to illustrate, but not to limit, the claimed invention.

Example 1. Library Screening Method

[0100] This example illustrates the screening of a mutant DNA polymerase library. The cDNA library was constructed by cloning genes of DNA polymerases {i.e., 9N-A485L DNA polymerase (SEQ ID NO: 2) and 9°N-Native DNA polymerase) into expression plasmids. The polymerase genes were mutated at specific nucleotide positions to create the mutant DNA polymerases (see Table 1 and the sequences of Table 7). A primer extension assay was used to estimate the polymerase activity of the various mutants that were generated.

[0101] Library Construction. Therminator™ DNA polymerase (i.e., 9N-A485L; SEQ ID NO: 2) and 9°N-Native DNA polymerase genes were obtained from New England Biolabs. The genes were cloned into an arabinose-inducible expression plasmid (pBAD, Invitrogen). Mutations were introduced at specific nucleotide positions using the QuikChange™ site- directed mutagenesis kit according to the manufacturer's instructions (Stratagene). Preferably, all three nucleotides of a target codon were randomized using a single degenerate oligonucleotide in order to generate the mutant DNA polymerase library containing all 20 amino acids at that position. Multiple codons were randomized using multiple degenerate oligonucleotides targeting multiple sites in a single mutagenesis reaction (Stratagene), or by randomizing a second position starting from a library already randomized at a first position.

[0102] Protein Expression And Extraction. Single colonies of library clones were grown overnight in 96- well plates containing 100 μl of growth medium per well. The clones were subcultured by diluting (overnight) cultures 100-fold into a fresh culture plate containing 100 μl of growth medium supplemented with 0.04% arabinose to induce protein expression. After 4 hour growth at 37°C, 20 μl of lysis solution (10 mM TrisCl pH 8, 0.8% IGEPAL) was added to each well, the plate was sealed with foil and heated at 75°C for 10 min. Cell lysates were stored at 4°C for up to 2 weeks with little loss of thermophilic polymerase activity.

[0103] Polymerase Assay. A primer extension assay was used to estimate polymerase activity. The primer is 5'-labeled with a fluorophore (e.g., FAM), and the template is 3'- labeled with a quencher (e.g., Black Hole Quencher I, Biosearch Technologies). Primer extension by polymerase was estimated by melt-curve analysis of the template-primer duplex using a real-time PCR instrument (Opticon I, MJ Research). The fluorescence signal increased as the duplex melted and the fluorescent primer strand separated from the template strand. As the primer is extended by polymerase, the T_m increases. Reactions were performed in duplicate, with one sample (96-well plate) containing unlabeled nucleotides and the other PEG-labeled nucleotides. Each mutant was scored by taking the ratio of activity between unlabeled and PEG-labeled nucleotides, in order to normalize for variation in the amount of polymerase in each well. Mutants showing a higher ratio of activity with PEG- labeled in comparison to unlabeled nucleotides were selected for further characterization. Alternatively, if the protein amounts were sufficiently uniform from sample to sample, improved mutants were selected based on their activity with PEG-labeled nucleotides alone.

[0104] Reactions contained 0.1 - 5.0 μl cell lysate, 0.2% NP-40 (contributed by cell lysate and supplemented as necessary, depending on lysate volume), 20 mM Tris-Cl pH 9.2, 50 mM KCl, 5 mM MgSO₄, 150 nM template (S'-CGGCTGCCTGGCGCGTCGGAGTGCTCA), 100 nM primer (S'-FAM-TGAGCACTCCGACGCGCCA), and either unlabeled nucleotides or PEG-labeled nucleotides. A chemically synthesized "full length" primer (5'-FAM- TGAGCACTCCGACGCGCCAGGCAGCCG) is utilized in a control sample as explained below. Preferably, unlabeled nucleotides were used at 1 μM each, and PEG-labeled nucleotides were at 200 μM each; a mixture of all four nucleotides A, C, G and T was used in each reaction mix. The preferred incubation temperature was 68⁰C and the preferred incubation time is 1 - 30 min. To capture mutant polymerases with low temperature activity a two stage incubation was performed (i.e., 4OC then 68C). After incubation, melting data was acquired at 1°C intervals from 65°C to 90°C. Reaction conditions (i.e., lysate amount, nucleotide concentration, incubation temperature, incubation time) were adjusted so that the primer was partly extended, allowing detection of either increased (long extension) or decreased (short extension) activity of each tested polymerase mutant.

[0105] Analysis. Melt curves are analyzed by a software program (written in the

Lab VIEW G programming language, National Instruments Inc.) as follows. The raw data comprises fluorescence F at each temperature T from 65⁰C to 9O⁰C. The F values are smoothed with the standard Lab VIEW median filter (window parameter = 2) and the first derivative dF/dT is taken at each temperature point T along the curve. The same median filter is applied to the dF/dT values, and the resulting smoothed dF/dT values are rescaled between 0-1 such that the minimum dF/dT value is 0.0 and the maximum 1.0, with all other values in between. The rescaled (0-1) dF/dT values (at each temperature T) are summed over two user-defined temperature ranges: for example, a low temperature range 68C to 77C (lowRangeSum) and a high temperature range 78C to 85C (highRangeSum). The obtained lowRangeSum and highRangeSum values are normalized such that

lowRangeSum + highRangeSum = 1.

The raw score for polymerase activity is given by

rawScore = highRangeSum - lowRangeSum where rawScore ranges -1 to +1 (the -1 extreme if lowRangeSum = 1 and highRangeSum = 0; and the +1 extreme if lowRangeSum = 0 and highRangeSum = 1).

[0106] The rawScore data for all samples is normalized between two control samples run in the same sample set as the mutant polymerases. Both controls utilize E. coli lysates from cells that express no thermostable polymerase activity. The "unextended" control contains the same primer used in the test samples, but the primer remains unextended because there is no active polymerase. The "full extension" control contains the "full length" primer sequence defined above. Each rawScore is normalized between the controls as

activityScore = (rawScore i - noExt) / (fullExt - noExt),

where activityScore is the normalized score, rawScore_i is the rawScore for the i^th sample, noExt is the rawScore of the unextended control, and fullExt is the rawScore of the full extension control. The activityScore values are used to rank mutant polymerases relative to their respective parent polymerase in order to identify mutant polymerases with improved activity.

[0107] The activityScore as defined above is a highly reproducible way to rank polymerase activity. Alternative methods include, for example, determining the melting temperature from F vs T data or dF/dT vs T data (Wittwer CT, Reed GH, Gundry CN, Vandersteen JG, Pryor RJ (2003) Clinical Chemistry 49: 853-860).

[0108] Results. Mutant polymerases selected from different libraries were compared on a single 96-well assay plate using 9N-A485L as a control. Scores were determined for PEG- labeled nucleotides only, without comparison to unlabeled nucleotides. The activityScore of each mutant were given relative to a control polymerease, e.g., 9N-A485L, where the activityScore of 9N-A485L has been normalized to 1.0. A relative score > 1.0 indicates=d an improvement over the 9N-A485L with respect to the utilization of PEG-labeled nucleotides, while a relative score < 1.0 indicated reduced activity. Corresponding rates of phosphate- labeled nucleotide incorporation were determined and the mutant 9N polymerases were sorted according to their activities relative to 9N-485L (SEQ ID NO. 2). The results are compiled in Table 1. An asterix ("*") in the score column in Table 1 means that the relative rate of nucleotide incorporation by the mutant DNA polymerase versus 9N-485L is 0.99 or less; a "+" means that the relative rate is between 1 and 2.99; a "++" means the relative rate is between 3 and 6.99; and a "+++" means the relative rate as measured by the assay (see Example 1) is between 7 and 23 times faster. [0109] Similar protocols were used to prepare and study phosphate region mutants of Taq DNA polymerase and Klenow DNA polymerase. Taq DNA polymerase mutants with improved rates of phosphate-labeled nucleotide incorporation are shown in Table 2, and Klenow DNA polymerase mutants with improved rates of phosphate-labeled nucleotide incorporation are shown in Table 3.

Table 2 Summary of Mutant Klenow DNA Polymerases

Table 3 Summary of Mutant Taq DNA Polymerases

EXAMPLE 2: Gel Extension Assay of Mutant Polymerase Activity

[0110] A gel extension assay using saturating amounts of selected purified mutant DNA polymerases was used to analyze their activity. Each enzyme was incubated at 68°C for 30 seconds with an IRDye700 labeled primer hybridized to ssM13mpl8 and saturating amounts of phosphate-labeled nucleotides. Reactions were resolved on a 10% TBE-Urea gel using a LI-COR 4200 DNA Analyzer. The average rate (nucleotides per second) for each of the indicated enzymes was calculated. The results are shown in Figures 10 and 11.

EXAMPLE 3: Defining phosphate regions of DNA polymerases

[0111] Taq DNA polymerase (Family A). Taq DNA polymerase was analyzed using public-domain software (Swiss-PDB Viewer version 3.7, http://ca.expasy.org/spdbv/). Initially, the protein (lQTM.pdb; Berman et al., Nucleic Acids Res, 28:235 (2000)) was divided into 2 regions by a plane parallel to the two paired bases in the active site {i.e., parallel to the aromatic ring moieties of both the bound dTTP and of the templating adenosine). This was accomplished in "slab" view (slab depth 100 A), by both rotating the model and translating the slab until the two bases were co-planar with the slab. The model was oriented with the phosphate groups of dTTP pointed into the display screen. The slab was then translated further into the screen to hide from view both bases as well as the alpha and beta phosphates of dTTP, so that only the gamma phosphate and amino acids between the gamma phosphate and the protein surface were visible. Then, the set of visible amino acids was further narrowed by selecting only amino acids within 15 A of the dTTP. Secondary structure elements containing amino acids of the narrowed set define the phosphate region of Taq DNA polymerase (Table 5).

[0112] 9°N polymerase (Family B). The published structure of 9⁰N polymerase (lQHT.pdb) does not contain bound dNTP or template DNA. These two elements were therefore modeled into 9°N holoenzyme by structural alignment with RB69 DNA polymerase (HG9.pdb), using the structurally conserved palm domain as described for aligning polymerases eta and T7 (Trincao et al., MoI Cell, 8:417 (2001)). Four structurally conserved beta strands in the two palm domains were visually identified and aligned between RB69 (Y619-V627, G700-T703, R707-V712, K724-K726) and 9⁰N (Y538-A546, G586-V589,

K592-I597, T604-R606) using Swiss-PDB Viewer version 3.7 (http://ca.expasy.org/spdbv/). The structures were then superimposed using the function, "Fit molecules (from selection)," giving an RMS deviation of 2.49 A for 22 aligned alpha carbon atoms. All of the amino acids of 9°N, plus the DNA and dTTP groups from RB69, were merged into a single pdb file using the function "Create merged layer from selection" (see Figure 12). The phosphate region was defined as explained in this Example with respect to Taq polymerase (Table 5).

[0113] Phosphate regions of polymerase beta, eta and HIV-RT (Families X, Y and RT). Published structures of polymerases beta (2BPF.pdb) and HIV-RT (IRTD.pdb) contain bound dNTP and template DNA, enabling both to be analyzed as Taq and 9°N DNA polymerase were analyzed. Their phosphate regions are given in Table 5. Polymerase eta (1 JIH.pdb) was merged with template and dNTP from T7 DNA polymerase (lT7P.pdb) using the conserved palm domains provided in (Trincao et ah, (2001)) for this structural alignment. The phosphate region of polymerase eta is given in Table 5.

[0114] All publications and patent applications cited in this specification are herein incorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it will be readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.

Table 1 (Cont'd)

Table 1 (Cont'd)

Table 1 (Cont'd)

Table1 (Confd)

SCORE 329 332 333 336 338 351 352 354 355 356 357 359 360 363 407 408 409 446 447 448 449 450

Table 1 (Cont'd)

Table1 (Cont'd)

SCORE 451 452 453 454 460 461 464 471 477 480 483 484 485 487 490 491 492 493 494 496 497 501 503

Table1 (Cont'd)

SCORE 329 332 333 336 338 351 352 354 355 356 357 359 360 363 407 408 409 446 447 448 449 450

σ\

_{35433603937356535352313} SCORE _{40940840763555383363333323294} ⁴ ₄₆4⁷ O (

S_QD NO ₂E _I:

Q- QO SE_IDN _158: O SE_{Q I}D N _652:

SE_{Q I}D NO_118:

> O S_QO ₆E _ID N_38: Q Έ I-

SE_{Q I}D NO _708:

SE_{Q I}D NO _200: ^<ϊ _QO ₂₄ SE _ID N_{8: Q}D NO SE _{I 596:}

CO O₉ SE_{Q I}D N _{68: Q}O SE _ID N _574:

_J SE_{Q I}D NO _680:

SE_{Q I}D NO _604:

SE_{Q I}D NO _590:

SE_{Q I}D NO _{396: Q}O ₂ SE _ID N_78:

CR O SEQ _ID N _{676: Q}O SE _ID N _212: O SE_{Q I}D N _282:

_J SE_QD NO _{74 I8: Q}O SE _ID N _270:

U- S_QO₈E _ID N _{20: Q}O SE _ID N _674: O SE_{Q I}D N _612:

B _QO SE _ID N _684:

O υ SE_{Q I}D NO _660:

LU S_QO ₂₃E _ID N4_:

S_QO ₆E _ID N_10:

I _l SEQD NO_{9 I 52:}

H

^■z.

O

_ι

_ι

σ

Έ CO

8 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Table 1 (Cont'd)

SCORE 448449450451452453454460461464471 477480483484485487490491 492493494496497501 503

4-

n o

C

3

Table 1 (Cont'd)

Table 1 (Cont'd)

Table 1 (Cont'd)

SCORE 448449450451452453454460461 464471 477480483484485487490491 492493494496497501 503

Table 1 (Cont'd)

SCORE 329 332 333 336 338 351 352 354 355 356 357 359 360 363 407 408 409 446 447

Table 1 (Cont'd)

Table 1 (Cont'd)

Table 1 (Cont'd)

Table 1 (Contd) '

SCORE 329 332 333 336 338 351 352 354 355 356 357 359 360 363 407 408 409 446 447

++ SEQ ID NO: 314 - - - - - - - - - - - - - - - W - - -

++ SEQ ID NO:488 - - - - - - - - A - - - - - - W - - -

++ SEQ ID NO:648 - - - - - - - - A - - - - - - W A - -

++ SEQ ID NO: 736 - - - - - - - - A - - - - - - W - - -

Ul

00

Table 1 (Confd)

Table1 (Cont'd)

SCORE 449 450 451 452 453 454 460 461 464 471 477 480 483 484 485 487 490 491 492 493 494 496 497 501 503

Table 1 (Conf d)

Table 1 (Conf d)

Table 1 (Conf d)

Table 1 (Confd)

Native DNA Polymerases.

Nucleic acid sequence of 9⁰N Polymerase (SEQ ID NO. 757) Comments: No inteins present in this sequence Genbank accession number U47108

TCCAGAGTTGTTTTACGAGGTTATGGGTGGTGAGTTCTCATGATTCTCGATACCGACTACATCACCGAGA ACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTTTAAAATCGAGTACGACAGAACCTT CGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCAAGAAGGTAACCGCAAAG AGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGCAGGCCGATAG AGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCACCC CGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATT CCGATGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGACATCGAAACGCTCTATCACGAGGGCGAGG AGTTCGGAACCGGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAA GAAGATTGACCTTCCGTACGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTC GTCAGGGAGAAGGACCCCGACGTGCTCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGA AGCGCTGTGAGGAACTCGGAATAAAGTTCACACTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAAT GGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCACTTCGACCTCTACCCCGTCATAAGGCGCACG ATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCTTTGGAAAGCCCAAGGAGAAGGTTT ACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTTGCAAGATACTCGATGGA GGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTCGAGGCTTATA GGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGAAGG CCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTA CGCTGGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCG CTGTATCCTTCAATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGT ACGACGTCGCCCCTGAGGTTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGG AGATTTGCTCGAGGAGAGGCAGAAGATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAA CTCCTCGATTACAGGCAGAGGGCTATCAAAATCCTCGCCAACAGCTTCTACGGCTACTACσσCTACGCCA AGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTACGGCCTGGGGAAGGGAGTATATAGAAATGGT TATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCCGATACAGACGGTCTCCATGCTACC ATTCCCGGAGCAGACσCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAAATACATTAATCCAAAAC TGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGAAGAAGAAGTA CGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGCGAG ATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTA GGATAGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGA GCAGATAACGCGCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCG GCGCGTGGAGTGAAAATCCGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAG GCGACAGGGCGATTCCAGCTGATGAGTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGA GAACCAGGTTCTCCCGGCGGTGGAGAGGATTCTAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTAC CAGAAGACGAAGCAGGTCGGCTTGGGCGCGTGGCTGAAGGTGAAGGGGAAGAAGTGAGGAAAACCCTTTT ACCCTTGCAATACAAATTGTATTTCGAG

Aminoacidsequenceof9⁰NPolymerase(SEQIDNO.758) Comments: inteinsremoved

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKD

DSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLGRPIEVWKLYFNHPQDVPAIRDRIRA

HPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFDIETLYHEGEEFGTGPILMI

SYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAY

LKKRCEELGIKFTLGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLE

AVYEAVFGKPKEKVYAEEIAQAWESGEGLERVARYSMEDAKVTYELGREFFPMEAQLS

RLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYAGGYVKEP

ERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIP

SLLGDLLEERQKIKRKMKATVD^'PLEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKE

CAESVTAWGREYIEMVIRELEEKFGFKVLYADTDGLHATIPGADAETVKKKAKEFLKY Table 6 (cont.)

INPKLpδϊiϊ,St-BΫMfeyM<3FFΛ)TJ^^ft^it)SEQKITTRσLEIVRRDWSEIAKETQA RVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAV AKRIJAARGVKIRPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPA VER I LKAFGYRKEDLRYQKTKQVGLGAWLKVKGKK

Nucleic Acid Sequence of Vent DNA Polymerase (SEQ ID NO. 759)

Comments: Vent polymerase is Polymerase gene from Thermococcus litoralis

The DNA sequence encodes wild type vent polymerase, containing exonuclease region and inteins. There are two protein sequences associated with this sequence - with and without inteins.

Genbank database - accession number M74198

GAATTCGCGATAAAATCTATTTTCTTCCTCCATTTTTCAATTTCAAAAACGTAAGCATGAGCCAAACCTC TCGCCCTTTCTCTGTCCTTCCCGCTAACCCTCTTGAAAACTCTCTCCAAAGCATTTTTTGATGAAAGCTC ACGCTCCTCTATGAGGGTCAGTATATCTGCAATGAGTTCGTGAAGGGTTATTCTGTAGAACAACTCCATG ATTTTCGATTTGGATGGGGGTTTAAAAATTTGGCGGAACTTTTATTTAATTTGAACTCCAGTTTATATCT GGTGGTATTTATGATACTGGACACTGATTACATAACAAAAGATGGCAAGCCTATAATCCGAATTTTTAAG AAAGAGAACGGGGAGTTTAAAATAGAACTTGACCCTCATTTTCAGCCCTATATATATGCTCTTCTCAAAG ATGACTCCGCTATTGAGGAGATAAAGGCAATAAAGGGCGAGAGACATGGAAAAACTGTGAGAGTGCTCGA TGCAGTGAAAGTCAGGAAAAAATTTTTGGGAAGGGAAGTTGAAGTCTGGAAGCTCATTTTCGAGCATCCC CAAGACGTTCCAGCTATGCGGGGCAAAATAAGGGAACATCCAGCTGTGGTTGACATTTACGAATATGACA TACCCTTTGCCAAGCGTTATCTCATAGACAAGGGCTTGATTCCCATGGAGGGAGACGAGGAGCTTAAGCT CCTTGCCTTTGATATTGAAACGTTTTATCATGAGGGAGATGAATTTGGAAAGGGCGAGATAATAATGATT AGTTATGCCGATGAAGAAGAGGCCAGAGTAATCACATGGAAAAATATCGATTTGCCGTATGTCGATGTTG TGTCCAATGAAAGAGAAATGATAAAGCGTTTTGTTCAAGTTGTTAAAGAAAAAGACCCCGATGTGATAAT AACTTACAATGGGGACAATTTTGATTTGCCGTATCTCATAAAACGGGCAGAAAAGCTGGGAGTTCGGCTT GTCTTAGGAAGGGACAAAGAACATCCCGAACCCAAGATTCAGAGGATGGGTGATAGTTTTGCTGTGGAAA TCAAGGGTAGAATCCACTTTGATCTTTTCCCAGTTGTGCGAAGGACGATAAACCTCCCAACGTATACσCT TGAGGCAGTTTATGAAGCAGTTTTAGGAAAAACCAAAAGCAAATTAGGAGCAGAGGAAATTGCCGCTATA TGGGAAACAGAAGAAAGCATGAAAAAACTAGCCCAGTACTCAATGGAAGATGCTAGGGCAACGTATGAGC TCGGGAAGGAATTCTTCCCCATGGAAGCTGAGCTGGCAAAGCTGATAGGTCAAAGTGTATGGGACGTCTC GAGATCAAGCACCGGCAACCTCGTGGAGTGGTATCTTTTAAGGGTGGCATACGCGAGGAATGAACTTGCA CCGAACAAACCTGATGAGGAAGAGTATAAACGGCGCTTAAGAACAACTTACCTGGGAGGATATGTAAAAG AGCCAGAAAAAGGTTTGTGGGAAAATATCATTTATTTGGATTTCCGCAGTCTGTACCCTTCAATAATAGT TACTCACAACGTATCCCCAGATACCCTTGAAAAAGAGGGCTGTAAGAATTACGATGTTGCTCCGATAGTA GGATATAGGTTCTGCAAGGACTTTCCGGGCTTTATTCCCTCCATACTCGGGGACTTAATTGCAATGAGGC AAGATATAAAGAAGAAAATGAAATCCACAATTGACCCGATCGAAAAGAAAATGCTCGATTATAGGCAAAG GGCTATTAAATTGCTTGCAAACAGCATCTTACCCAACGAGTGGTTACCAATAATTGAAAATGGAGAAATA AAATTCGTGAAAATTGGCGAGTTTATAAACTCTTACATGGAAAAACAGAAGGAAAACGTTAAAACAGTAG AGAATACTGAAGTTCTCGAAGTAAACAACCTTTTTGCATTCTCATTCAACAAAAAAATCAAAGAAAGTGA AGTCAAAAAAGTCAAAGCCCTCATAAGACATAAGTATAAAGGGAAAGCTTATGAGATTCAGCTTAGCTCT GGTAGAAAAATTAACATAACTGCTGGCCATAGTCTGTTTACAGTTAGAAATGGAGAAATAAAGGAAGTTT CTGGAGATGGGATAAAAGAAGGTGACCTTATTGTAGCACCAAAGAAAATTAAACTCAATGAAAAAGGGGT AAGCATAAACATTCCCGAGTTAATCTCAGATCTTTCCGAGGAAGAAACAGCCGACATTGTGATGACGATT TCAGCCAAGGGCAGAAAGAACTTCTTTAAAGGAATGCTGAGAACTTTAAGGTGGATGTTTGGAGAAGAAA ATAGAAGGATAAGAACATTTAATCGCTATTTGTTCCATCTCGAAAAACTAGGCCTTATCAAACTACTGCC CCGCGGATATGAAGTTACTGACTGGGAGAGATTAAAGAAATATAAACAACTTTACGAGAAGCTTGCTGGA AGCGTTAAGTACAACGGAAACAAGAGAGAGTATTTAGTAATGTTCAACGAGATCAAGGATTTTATATCTT ACTTCCCACAAAAAGAGCTCGAAGAATGGAAAATTGGAACTCTCAATGGCTTTAGAACGAATTGTATTCT CAAAGTCGATGAGGATTTTGGGAAGCTCCTAGGTTACTATGTTAGTGAGGGCTATGCAGGTGCACAAAAA AATAAAACTGGTGGTATCAGTTATTCGGTGAAGCTTTACAATGAGGACCCTAATGTTCTTGAGAGCATGA AAAATGTTGCAGAAAAATTCTTTGGCAAGGTTAGAGTTGACAGAAATTGCGTAAGTATATCAAAGAAGAT GGCATACTTAQTTATGAAATGCCTCTGTGGAGCATTAGCCGAAAACAAGAGAATTCCTTCTGTTATACTC ACCTCTCCCGAACCGGTACGGTGGTCATTTTTAGAGGCGTATTTTACAGGCGATGGAGATATACATCCAT Table 6 (cont.)

GGGAATATCCTCTGTAAAGATAGGCTTTGACAGTGGGQTCTATAGAGTGTATATAAATGAAGACCTQCAA TTTCCACAAACGTCTAGGGAGAAAAACACATACTACTCTAACTTAATTCCCAAAGAGATCCTTAGGGACG TGTTTGGAAAAGAGTTCCAAAAGAACATGACGTTCAAGAAATTTAAAGAGCTTGTTGACTCTGGAAAACT TAACAGGGAGAAAGCCAAGCTCTTGGAGTTCTTCATTAATGGAGATATTGTCCTTGACAGAGTCAAAAGT GTTAAAGAAAAGGACTATGAAGGGTATGTCTATGACCTAAGCGTTGAGGATAACGAGAACTTTCTTGTTG GTTTTGGTTTGCTCTATGCTCACAACAGCTATTACGGCTATATGGGGTATCCTAAGGCAAGATGGTACTC GAAGGAATGTGCTGAAAGCGTTACCGCATGGGGGAGACACTACATAGAGATGACGATAAGAGAAATAGAG GAAAAGTTCGGCTTTAAGGTTCTTTATGCGGACAGTGTCTCAGGAGAAAGTGAGATCATAATAAGGCAAA ACGGAAAGATTAGATTTGTGAAAATAAAGGATCTTTTCTCTAAGGTGGACTACAGCATTGGCGAAAAAGA ATACTGCATTCTCGAAGGTGTTGAAGCACTAACTCTGGACGATGACGGAAAGCTTGTCTGGAAGCCCGTC CCCTACGTGATGAGGCACAGAGCGAATAAAAGAATGTTCCGCATCTGGCTGACCAACAGCTGGTATATAG ATGTTACTGAGGATCATTCTCTCATAGGCTATCTAAACACGTCAAAAACGAAAACTGCCAAAAAAATCGG GGAAAGACTAAAGGAAGTAAAGCCTTTTGAATTAGGCAAAGCAGTAAAATCGCTCATATGCCCAAATGCA CCGTTAAAGGATGAGAATACCAAAACTAGCGAAATAGCAGTAAAATTCTGGGAGCTCGTAGGATTGATTG TAGGAGATGGAAACTGGGGTGGAGATTCTCGTTGGGCAGAGTATTATCTTGGACTTTCAACAGGCAAAGA TGCAGAAGAGATAAAGCAAAAACTTCTGGAACCCCTAAAAACTTATGGAGTAATCTCAAACTATTACCCA AAAAACGAGAAAGGGGACTTCAACATCTTGGCAAAGAGCCTTGTAAAGTTTATGAAAAGGCACTTTAAGG ACGAAAAAGGAAGACGAAAAATTCCAGAGTTCATGTATGAGCTTCCGGTTACTTACATAGAGGCATTTCT ACGAGGACTGTTTTCAGCTGATGGTACTGTAACTATCAGGAAGGGAGTTCCAGAGATCAGGCTAACAAAC ATTGATGCTGACTTTCTAAGGGAAGTAAGGAAGCTTCTGTGGATTGTTGGAATTTCAAATTCAATATTTG CTGAGACTACTCCAAATCGCTACAATGGTGTTTCTACTGGAACCTACTCAAAGCATCTAAGGATCAAAAA TAAGTGGCGTTTTGCTGAAAGGATAGGCTTTTTAATCGAGAGAAAGCAGAAGAGACTTTTAGAACATTTA AAATCAGCGAGGGTAAAAAGGAATACCATAGATTTTGGCTTTGATCTTGTGCATGTGAAAAAAGTCGAAG AGATACCATACGAGGGTTACGTTTATGACATTGAAGTCGAAGAGACGCATAGGTTCTTTGCAAACAACAT CCTGGTACACAATACTGACGGCTTTTATGCCACAATACCCGGGGAAAAGCCTGAACTCATTAAAAAGAAA GCCAAGGAATTCCTAAACTACATAAACTCCAAACTTCCAGGTCTGCTTGAGCTTGAGTATGAGGGCTTTT ACTTGAGAGGATTCTTTGTTACAAAAAAGCGCTATGCAGTCATAGATGAAGAGGGCAGGATAACAACAAG GGGCTTGGAAGTAGTAAGGAGAGATTGGAGTGAGATAGCTAAGGAGACTCAGGCAAAGGTTTTAGAGGCT ATACTTAAAGAGGGAAGTGTTGAAAAAGCTGTAGAAGTTGTTAGAGATGTTGTAGAGAAAATAGCAAAAT ACAGGGTTCCACTTGAAAAGCTTGTTATCCATGAGCAGATTACCAGGGATTTAAAGGACTACAAAGCCAT TGGCCCTCATGTCGCGATAGCAAAAAGACTTGCCGCAAGAGGGATAAAAGTGAAACCGGGCACAATAATA AGCTATATCGTTCTCAAAGGGAGCGGAAAGATAAGCGATAGGGTAATTTTACTTACAGAATACGATCCTA GAAAACACAAGTACGATCCGGACTACTACATAGAAAACCAAGTTTTGCCGGCAGTACTTAGGATACTCGA AGCGTTTGGATACAGAAAGGAGGATTTAAGGTATCAAAGCTCAAAACAAACCGGCTTAGATGCATGGCTC AAGAGGTAGCTCTGTTGCTTTTTAGTCCAAGTTTCTCCGCGAGTCTCTCTATCTCTCTTTTGTATTCTGC TATGTGGTTTTCATTCACTATTAAGTAGTCCGCCAAAGCCATAACGCTTCCAATTCCAAACTTGAGCTCT TTCCAGTCTCTGGCCTCAAATTCACTCCATGTTTTTGGATCGTCGCTTCTCCCTCTTCTGCTAAGCCTCT CGAATCTTTTTCTTGGCGAAGAGTGTACAGCTATGATGATTATCTCTTCCTCTGGAAACGCATCTTTAAA CGTCTGAATTTCATCTAGAGACCTCACTCCGTCGATTATAACTGCCTTGTACTTCTTTAGTAGTTCTTTT ACCTTTGGGATCGTTAATTTTGCCACGGCATTGTCCCCAAGCTCCTGCCTAAGCTGAATGCTCACACTGT TCATACCTTCGGGAGTTCTTGGGATCC

Amino Acid Sequence of Vent DNA Polymerase containing 3 exteins and 2 inteins

(SEQ ID NO. 760)

MILDTDYITKDGKPIIRIFKKENGEFKIELDPHFQPYIYALLKD DSAIEEIKAIKGERHGKTVRVLDΆVKVRKKFLGREVEVWKLIFEHPQDVPAMRGKIRE HPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELKLLAFDIETFYHEGDEFGKGEIIMI SYADEEEARVITWKNIDLPYVDWSNEREMIKRFVQWKEKDPDVIITYNGDNFDLPY

LIKRAEKLGVRLVLGRDKEHPEPKIQRMGDSFAVEIKGRIHFDLFPWRRTINLPTYT

LEAVΎEAVLGKTKSKLGAEEIAAIWETEESMKKLAQYSMEDARATYELGKEFFPMEAE LAKLIGQSVWDVSRSSTGNLVEWYLLRVAYARNELAPNKPDEEEYKRRLRTTYLGGYV KEPEKGLWENIIYLDFRSLYPSIIVTHNVSPDTLEKEGCKNYDVAPIVGYRFCKDFPG FIPSILQDLIAMRQDIKKKMKSTIDPIEKKMLDYRQRAIKLLANSILPNEWLPIIENG Table 6 (cont)

W

Table 6 (cont)

Table 6 (cont.)

Nucleic Acid Sequence of Phi-29 DNA Polymerase (SEQ ID NO. 764)

Phi-29 polymerase

Genbank database - accession number VOl 155.1 base 1145 to 2872

ATGAAGCATATGCCGAGAAAGATGTATAGTTGTGACTTTGAGACAACTACTAAAGTGGAAGACTGTAGGGTATGGGC GTATGGTTATATGAATATAGAAGATCACAGTGAGTACAAAATAGGTAATAGCCTGGATGAGTTTATGGCGTGGGTGT TGAAGGTACAAGCTGATCTATATTTCCATAACCTCAAATTTGACGGAGCTTTTATCATTAACTGGTTGGAACGTAAT GGTTTTAAGTGGTCGGCTGACGGATTGCCAAACACATATAATACGATCATATCTCGCATGGGACAATGGTACATGAT TGATATATGTTTAGGCTACAAAGGGAAACGTAAGATACATACAGTGATATATGACAGCTTAAAGAAACTACCGTTTC CTGTTAAGAAGATAGCTAAAGACTTTAAACTAACTGTTCTTAAAGGTGATATTGATTACCACAAAGAAAGACCAGTC

GTTTAAGCAAGGTTTAGACCGGATGACAGCAGGCAQTGACAGTCTAAAAGGTTTCAAGGATATTATAACCACTAAGA AATTCAAAAAGGTGTTTCCTACATTGAGTCTTGGACTCGATAAGGAAGTGAGATACGCCTATAGAGGTGGTTTTACA

GATGTATAGTCGTCTCCTTCCATATGGTGAACCTATAGTATTCGAGGGTAAATACGTTTGGGACGAAGATTACCCAC TACACATACAGCATATCAGATGTGAGTTCGAATTGAAAGAGGGCTATATACCCACTATACAGATAAAAAGAAGTAGG

ATTAATGAAAGAACACTACGATTTATATAACGTTGAATATATCAGCGGCTTAAAATTTAAAGCAACTACAGGTTTGT

TTAAACAGTCTATACGGTAAATTCGCTAGTAACCCTGATGTTACAGGGAAAGTCCCTTATTTAAAAGAGAATGGGGC GCTAGGTTTCAGACTTGGAGAAGAGGAAACAAAAGACCCTGTTTATACACCTATGGGCGTTTTCATCACTGCATGGG CTAGATACACGACAATTACAGCGGCACAGGCTTGTTATGATCGGATAATATACTGTGATACTGACAGCATACATTTA

GGTTCTGGTTGATGACACATTCACAATCAAATAA

Amino Acid Sequence of Phi-29 DNA Polymerase (SEQ ID NO. 765)

MKHMPRKMYSCDFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSL

DEFMAWVLKVQADLYFHNLKFDGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYM

IDICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPVGYKITP

EEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITTKKFKKVFPTLSLGL

DKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLYPAQMYSRLLPYGEPIVFEGKYV

WDEDYPLHIQHIRCEFELKEGYIPTIQIKRSRFYKGNEYLKSSGGEIADLWLSNVDLE

LMKEHYDLYNVEYISGLKFKATTGLFKDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGK

FASNPDVTGKVPYLKENGALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYD

RIIYCDTDSIHLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKE

VDGKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQVPGGW

LVDDTFTIK

Nucleic Acid Sequence of Ecoli DNA Polymerase I ((SEQ ID NO. 766)

Comments: E.coli polymerase I contains both 3'to 5' and 5'to 3' exonuclease activity. The Kl enow native polymerase is contained within this sequence and does not contain the 5'to 3' exonuclease region. Genbank database - Accession number V00317 Table6(cont.)

ATCC

TGGAT¹TTATTTTTAACTGCATGAAAAACAAAGACAAACATCATGCTGTAAAAAGCATGATAATAAATTAA

AAGCGATGTAAATAATTTATGCACAAAGTTATCCACATGACGATTTGCGAGCGATCCAGAAGATCTACAA

AAGATTTTCACGAAAAGCGGTGAAAAACTCATGTTTTCATCCTGTCTGTGGCATCCTTTACCCATAATCT

GATAAACAGGCACGGACATTATGGTTCAGATCCCCCAAAATCCACTTATCCTTGTAGATGGTTCATCTTA

TCTTTATCGCGCATATCACGCGTTTCCCCCGCTGACTAACAGCGCAGGCGAGCCGACCGGTGCGATGTAT

GGTGTCCTCAACATGCTGCGCAGTCTGATCATGCAATATAAACCGACGCATGCAGCGGTGGTCTTTGACG

CCAAGGGAAAAACCTTTCGTGATGAACTGTTTGAACATTACAAATCACATCGCCCGCCAATGCCGGACGA

TCTGCGTGCACAAATCGAACCCTTGCACGCGATGGTTAAAGCGATGGGACTGCCGCTGCTGGCGGTTTCT

GGCGTAGAAGCGGACGACGTTATCGGTACTCTGGCGCGCGAAGCCGAAAAAGCCGGGCGTCCGGTGCTGA

TCAGCACTGGCGATAAAGATATGGCGCAGCTGGTGACGCCAAATATTACGCTTATCAATACCATGACGAA

TACCATCCTCGGACCGGAAGAGGTGGTGAATAAGTACGGCGTGCCGCCAGAACTGATCATCGATTTCCTG

GCGCTGATGGGTGACTCCTCTGATAACATTCCTGGCGTACCGGGCGTCGGTGAAAAAACCGCGCAGGCAT

TGCTGCAAGGTCTTGGCGGACTGGATACGCTGTATGCCGAGCCAGAAAAAATTGCTGGGTTGAGCTTCCG

TGGCGCGAAAACAATGGCAGCGAAGCTCGAGCAAAACAAAGAAGTTGCTTATCTCTCATACCAGCTGGCG

ACGATTAAAACCGACGTTGAACTGGAGCTGACCTGTGAACAACTGGAAGTGCAGCAACCGGCAGCGGAAG

AGTTGTTGGGGCTGTTCAAAAAGTATGAGTTCAAACGCTGGACTGCTGATGTCGAAGCGGGCAAATGGTT

ACAGGCCAAAGGGGCAAAACCAGCCGCGAAGCCACAGGAAACCAGTGTTGCAGACGAAGCACCAGAAGTG

ACGGCAACGGTGATTTCTTATGACAACTACGTCACCATCCTTGATGAAGAAACACTGAAAGCGTGGATTG

CGAAGCTGGAAAAAGCGCCGGTATTTGCATTTGATACCGAAACCGACAGCCTTGATAACATCTCTGCTAA

CCTGGTCGGGCTTTCTTTTGCTATCGAGCCAGGCGTAGCGGCATATATTCCGGTTGCTCATGATTATCTT

GATGCGCCCGATCAAATCTCTCGCGAGCGTGCACTCGAGTTGCTAAAACCGCTGCTGGAAGATGAAAAGG

CGCTGAAGGTCGGGCAAAACCTGAAATACGATCGCGGTATTCTGGCGAACTACGGCATTGAACTGCGTGG

GATTGCGTTTGATACCATGCTGGAGTCCTACATTCTCAATAGCGTTGCCGGGCGTCACGATATGGACAGC

CTCGCGGAACGTTGGTTGAAGCACAAAACCATCACTTTTGAAGAGATTGCTGGTAAAGGCAAAAATCAAC

TGACCTTTAACCAGATTGCCCTCGAAGAAGCCGGACGTTACGCCGCCGAAGATGCAGATGTCACCTTGCA

GTTGCATCTGAAAATGTGGCCGGATCTGCAAAAACACAAAGGGCCGTTGAACGTCTTCGAGAATATCGAA

ATGCCGCTGGTGCCGGTGCTTTCACGCATTGAACGTAACGGTGTGAAGATCGATCCGAAAGTGCTGCACA

ATCATTCTGAAGAGCTCACCCTTCGTCTGGCTGAGCTGGAAAAGAAAGCGCATGAAATTGCAGGTGAGGA

ATTTAACCTTTCTTCCACCAAGCAGTTACAAACCATTCTCTTTGAAAAACAGGGCATTAAACCGCTGAAG

AAAACGCCGGGTGGCGCGCCGTCAACGTCGGAAGAGGTACTGGAAGAACTGGCGCTGGACTATCCGTTGC

CAAAAGTGATTCTGGAGTATCGTGGTCTGGCGAAGCTGAAATCGACCTACACCGACAAGCTGCCGCTGAT

GATCAACCCGAAAACCGGGCGTGTGCATACCTCTTATCACCAGGCAGTAACTGCAACGGGACGTTTATCG

TCAACCGATCCTAACCTGCAAAACATTCCGGTGCGTAACGAAGAAGGTCGTCGTATCCGCCAGGCGTTTA

TTGCGCCAGAGGATTATGTGATTGTCTCAGCGGACTACTCGCAGATTGAACTGCGCATTATGGCGCATCT

TTCGCGTGACAAAGGCTTGCTGACCGCATTCGCGGAAGGAAAAGATATCCACCGGGCAACGGCGGCAGAA

GTGTTTGGTTTGCCACTGGAAACCGTCACCAGCGAGCAACGCCGTAGCGCGAAAGCGATCAACTTTGGTC

TGATTTATGGCATGAGTGCTTTCGGTCTGGCGCGGCAATTGAACATTCCACGTAAAGAAGCGCAGAAGTA

CATGGACCTTTACTTCGAACGCTACCCTGGCGTGCTGGAGTATATGGAACGCACCCGTGCTCAGGCGAAA

GAGCAGGGCTACGTTGAAACGCTGGACGGACGCCGTCTGTATCTGCCGGATATCAAATCCAGCAATGGTG

CTCGTCGTGCAGCGGCTGAACGTGCAGCCATTAACGCGCCAATGCAGGGAACCGCCGCCGACATTATCAA

ACGGGCGATGATTGCCGTTGATGCGTGGTTACAGGCTGAGCAACCGCGTGTACGTATGATCATGCAGGTA

CACGATGAACTGGTATTTGAAGTTCATAAAGATGATGTTGATGCCGTCGCGAAGCAGATTCATCAACTGA

TGGAAAACTGTACCCGTCTGGATGTGCCGTTGCTGGTGGAAGTGGGGAGTGGCGAAAACTGGGATCAGGC

GCACTAAGATTCGCCTGAACATGCCTTTTTTCGTAAGTAAGCAACATAAGCTGTCACGTTTTGTGATGGC

TATTAGAAATTCCTATGCAACAACTGAAAAAAAATTACAA

AminoAcidSequenceofEcoliDNAPolymeraseI(SEQIDNO.767)

MVQIPQNPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLN

MLRSLIMQYKPTHAAWFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAM

GLPLLAVSGVEADDVIGTLAREAEKAGRPVLISTGDKDMAQLVTPNITLINTMTNTIL

GPEEWNKYGVPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEP

EKIAGLSFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVELELTCEQLEVQQPAAEELL

GLFKKYEFKRWTADVEAGKWLQAKGAKPAAKPQETSVADEAPEVTATVISYDNYVTIL

DEETLKAWIAKLEKAPVFAFDTETDSLDNISANLVGLSFAIEPGVAAYIPVAHDYLDA

TABLE 7 9°N-A485L and 9°N Mutant DNA Polymerases

SEQ ID NO: 1

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

CCATCATCATCATCATCATTGA

SEQ ID NO: 2

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 3

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAACTTTC GAGGAGAATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 4

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRRIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 5

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA Table7(cont.)

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 6

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRRIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 7 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA SEQ ID NO: 8

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKR YLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV Table 7 (cont.)

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKR^'LAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 9

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCAfCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGAGCGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 10

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPSEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRRIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 11

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA Table7(cont.)

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGACAGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGGGGATCAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CCATCATCATCATCATCATTGA

SEQ ID NO: 12

MILDTDYITENGKPVIRVFKKENGEFKI EYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAE KVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPTEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRGIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 13 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGCAAGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCGCATCAAAAT Table7(cont.)

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 14

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPQEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRRIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 15 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

RPIEWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPIEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRKIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 17

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGCACGAGGCCCAGCTTTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 18

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPHEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRFIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 19 Table7(cont.)

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGACAGAGGCCCAGCTTTC GAGGGGTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 20

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPTEAQLSRGIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 21 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGGTTGAGGCCCAGCTTTC

CGA( Table7(cont.)

AGGCifcTlU:mGAMMffi⁽SAfflOTCd⁽i!;&<Mi3MCAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT, GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 22

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPVEAQLSRAIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 23 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATTGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table 7 (cont.)

GTTCG^'AlδeGGACθAPieGAGΘIGCTA'CtlΛifOΘCJΘΑATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAσGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 24

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKPLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMIIAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPIEAQLSRSIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 25 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA

SEQ ID NO: 26

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPTEAQLSRTIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table7(cont.)

EIAKETβARVLEAΪ&RMilWEEA^'i^^

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 27

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGGTCGAAGCCCAGCTTTC

GAGGTCGATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAG

GTGAAGGGGAAGAAGGGTACCG*

CCATCATCATCATCATCATTGA

SEQ ID NO: 28

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPVEAQLSRSIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTvisYivLKGSGRiGDRAiPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 29 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC Table7(cont.)

CTCQGCAGGGACSGGAGCGAGCCGMJMTA'C^GCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGCCTGAGGCCCAGCTTTC GAGGCGTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 30

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPPEAQLSRRIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 31

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGTGGATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA Table7(cont.)

AGM0M-GmeGCTGT©ATAζiAg!3AW^GK|QβAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 32

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPEEAQLSRWIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 33 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGACGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 34

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT Table7(cont.)

LGRD^isfePKlQ^tlDl'^^SVkG^ll&DLYP^tRRTINLPTYTLEAVYEAVFGKPKEKV^yAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPTEAQLSRKIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 35

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CCATCATCATCATCATCATTGA

SEQ ID NO: 36

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRGIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 37

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC Table7(cont.)

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGAAAATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCAAATCAAAAT

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 38

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRKIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRQIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 39 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG Table7(cont.)

ATAAAiGeGGMGAΦG^δGGΑAGβdiT'BAlGiCfeGCTGGAGAAGAAACTCCTCGATTACAσGCAGAGGCAAATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 40

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRFIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRQIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 41 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGAAAATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

GTGAAGGGGAAGAAGGGTACCG? CCATCATCATCATCATCATTGA Table 7 (cont.)

SEQ ID NO : 42

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVT AKRHGTWKVKRAE KVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRKISQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRKIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 43 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 44

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRSIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table 7 (cont.)

SEQ tD"^OV' 4S"

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 46

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRWIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRFIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVisYiVLKGSGRiGDRAiPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 47

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCGCCTTTC Table7(cont.)

GAGGCTΦAT'AGGeCA^βMeeT^'CΫδόδS^d-^'ΦdΦCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGGCCATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 48

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPA WDIYEYDIPFAKR YLIDKGLI PMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEARLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 49

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC Table7(cont.)

CGGCtfc^diACGδtGAϊAAδCtAέAt^'CΪiS^GiΦAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 50

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAVLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRRIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 51

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

GAGGCTTATAGGCCAGAGCCTCTGGGATGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 52

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAELSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRGIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table7(cont.)

DTDG^HATiPGADAETVKKKA^FXWiM^

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 53

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCσCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCACCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 54

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAHLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSILITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 55

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC Table 7 (cont.)

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGCGCGAGGCCCAGCTTTC GGAGTTCTTCCCGACGGAGGCCCAGCTTTCGAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCG GAAATTTGGTGGAGTGGTTCCTCCTGCGGAAGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGG GAGCTCGCGAGACGGCGCGGGGGCTACGCTGGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGT GTATTTAGACTTCCGCTCGCTGTATCCTTCAATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGG GCTGTAAAGAGTACGACGTCGCCCCTGAGGTTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTC CTGGGAGATTTGCTCGAGGAGAGGCAGAAGATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACT CCTCGATTACAGGCAGAGGCCGATCAAAATCCTCGCCAACAGTTACAGGCAGAGGTGGATCAAAATCCTCGCCAACA GCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTACGGCCTGGGGA AGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCCGATACAGACGG TCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAAATACATTAATC

GCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGCGAGATAGCGAA GGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGATAGTCAAGGAAG

GATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATCCGGCCCGGCAC

GGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAGGTGAAGGGGAA ATCATCATTGA

SEQ ID NO: 56

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPREAQLSEFFPTEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDER

LGDLLEERQKIKRKMKATVDPLEKKLLDYRQRPIKILANSYRQRWIKILANSFYGYYGYAKARWYCKECAESVTAWG

AVIDEEGKITTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLR DYKATGPHVAVAKRLAARGVKIRPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAF GYRKEDLRYQKTKQVGSGAWLKVKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 57

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCGGCCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCCCATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC Table7(cont.)

GATACAGACGGTCTCeATaG¹PAGG¹OTfTGOGtSIGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 58

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAGLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRPIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA SEQ ID NO: 60 Table7(cont.)

MILώtϋYlfl^dK&VrkVFlKkEN&BtlkIfe^iiTFEPYFyALLKDDSAIEDVKKVTAKRHGTVVK^KRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMIiAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAWLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 61

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACσCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGGAAATCAAAAT

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 62

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEARVSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQREIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 63 Table7(cont.)

ATGA!WeτCtaAτACceA*fl.CAΕ⁽IMd^C^CGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCGACCTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ■TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 64

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEARPSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRHIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 65

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCAGGGTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA Table7(cont.)

AGGtfCfACAA;δAGi3^C'GAδCT<^dt⁽13iεAMeAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACσC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCσCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 66

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEARVSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 61 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table 7 (cont.)

GTT(5MeCCGAdi3-mi3ekeCGC'PAOGAⁱt¹⁽Sfe⁽S⁽-iAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 68

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAI EDVKKVTAKRHGTWKVKRAE KVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEARDSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRFIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 69

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 70

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAAPSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRQRRIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS Table 7 (cont.)

EIAKtetfQARVLEA'TLKHGDVEEAVRΪVKEVTBKLSKYEVPPEKXVI^^

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHR YDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 71

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCTGTATATC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CCATCATCATCATCATCATTGA

SEQ ID NO: 72

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEACISRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRGIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 73 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA Table7(com.)

CTCfiδeπGGGACdm^d^'CtiAGCCG^Qk'rkeΑGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGTCGGAGGCCCAGCTTTC GAGGTGGATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 74

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWICVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEBLTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPSEAQLSRWIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 75 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGAGAATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA Table7(cont.)

AGAAGfAAGTACGWGtGATAGACGiAdGWyiSlGC^AGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 76

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPTEAQLSRRIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 77

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGTCAGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCσCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCσCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 78

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKR YLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT Table7(cont.)

ARYSMEDAKVTYELGREFPPSEAQLSRRIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 79

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 80

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPIEAQLSRTIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 81

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA Table7(cont.)

CCCdS^'dteTΪ'cόT^tøfcX'ϊ'CMCGAG'tl^'άάAciTACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGAAAATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGTTTATCAAAAT

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CCATCATCATCATCATCATTGA

SEQ ID NO: 82

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRKIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRFIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 83

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGATTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG Table7(cont.)

ATAAΗ3GGβAAGⁱA^!T<3iB-AOGCiU^^

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 84

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRIIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRTIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTViSYIVLKGSGRiGDRAiPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 85 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGTTGATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

GTGAAGGGGAAGAAGGGTACCG?

CCATCATCATCATCATCATTGA Table 7 (cont.)

SEQ ID NO : 86

M I LDTDY I TENGKPVI RVFKKENGE FKI EYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAE KVQKKFLG

RPIEVW KLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKR YLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAKLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 87

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA SEQ ID NO: 88

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEASLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRRIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table7(cont.)

SEQ¹¹ID¹¹NO: 89

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAACTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCGAATCAAAAT

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA SEQ ID NO: 90

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRRIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 91

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCACGCTTTC Table7(cont.)

GAGdCTΪAfAiSGϋcSb^'SfeC&ΪCTfeGGJΛC^cfCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGAAAATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 92

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEATLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRKIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTViSYiVLKGSGRiGDRAiPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* SEQ ID NO: 93

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC Table 7 (cont.)

CGGUrCfcGGbACOOtOSfMGCTAcAftfdfcdTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 94

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAICRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAKLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRQIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 95 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGTTTATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 96

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAYLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRFIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table 7 (cont.)

DTDOLI^TΪI^sGAlB^TVkK^'liAKΪ:!FL¹kΫΪ&&KtPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQAR VLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 97

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 98

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAALSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRRIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 99 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC Table7(cont.)

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCGGGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCGAATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 100

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAGLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRRIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 101

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCGTATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA Table7(cont.)

ATACAtTA^TCCAftMCTdfCCCtfGOCT^ISCtCbAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 102

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEADLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRRIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 103

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 104

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVW KLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATL YHEGEEFGT Table7(cont.)

_GPIL'tørsYAUGSEAKVΪTWKKIDfiPΫVϋW^

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEARLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 105

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 106

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPDEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 107

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC Table7(cont.)

AGGCCGATAGAGGTCTGGAAGCTCTΆCTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCTCCGTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGACAATCAAAAT

CCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTACGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAA

ACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGCGAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGAT CGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGCGCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCC TGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGAGTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACA

ACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGACCATCATCATCATCATCATTGA

SEQ ID NO : 108

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVT AKRHGTWKVKRAE KVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEASVSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRTIKILANSYRQRQIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRE LEEKFGFKVLYADTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKIT TRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVA VAKRLAARGVKIRPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQ KTKQVGSGAWLKVKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 109

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGATCTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table7(cont.)

TTGΘACACAAGTTCTGCATVGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCCGATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 110

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQISRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRPIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 111 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGATCTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table7(cont.)

GTGMG^GAAGMGGGTACCGAAGCTTA^afiAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 112

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQISRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 113 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 114

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRTIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI Table 7 (cont.)

RPGTWSYΪVLKGSGRΪGDRAIPADEFD PTKHR YD AEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 115

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 116

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRSIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 117

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCσCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGTGGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 118

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 119

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCσCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCTATGGCTTATAAAAAT

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC Table7(cont.)

GAGATAGCGAAGGAGACCCAGGGtAiSGGftTtAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCσCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 120

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 121

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CCATCATCATCATCATCATTGA

SEQ ID NO: 122

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVW KLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKR YLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV Table7(cont.)

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 123

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CCATCATCATCATCATCATTGA

SEQ ID NO: 124

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 125

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA Table7(cont.)

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGTATTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

CCATCATCATCATCATCATTGA

SEQ ID NO: 126

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 127 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT Table7(cont.)

CCTCGCCAACAGCTTCTACGGCfACTACCSGCtACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 128

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPTEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 129

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SBQ"ΠΓ.NO: i^'3ό^"

MIIiDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPPEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 131 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGAGCGAGGCCCAGCTTTC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 132

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPSEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 133 Table7(cont.)

ATGATfCTClG^'ATSCC^'GAGTAfcATCA&CiSAd^CGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGACGGAGGCCCAGCGTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 134

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPTEAQRSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 135

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGACGGAGGCCCAGCGCTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA Table7(cont.)

AGGdbτXfcAA<3AδδiOVC^'δAδCTCdcδddiitociAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCσCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 136

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPTEAQRSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 137

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table7(cont.)

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 138

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAFLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 139

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 140

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAGLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS Table 7 (cont.)

EIArafQARVLEAILIOIGDVEEΪ-^ΪVkMfEiαjSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 141

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCGTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 142

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQRSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 143

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA Table7(cont.)

CTCOGCfAGOGACGGGAGCGAGdGbAXGAfACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAAGACTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 144

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQDSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 145

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCGCTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA Table7(cont.)

AGAAGAAGTACGCTGTGAT^'^

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 146

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQRSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 147

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCCGTC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 148

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT Table7(cont.)

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQPSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRAIKILANSFYGYYOYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 149

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 150

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQGSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRAIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 151

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA Table 7 (cont.)

CCCCGCTGTCGTtGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCfCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGATAATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 152

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKR YLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRI IGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPS I I ITHNVSPDTLNREGCKE YDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKR KMKATVDPLEKKLLD YRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQAR VLEAILKHGDVE EAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 153

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGTCCATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG Table7(cont.)

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC σCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 154

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVT AKRHGTWKVKRAE KVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRSIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 155 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID NO: 156

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRFWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 157

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGTGGTTGATCAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 158

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPIEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table7(cont.)

SEQ ID NO: 159

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGAAAATCAAAAT

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 160

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRKIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 161

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCσCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC Table7(cont.)

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGCAGAGGCAAATCAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 162

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRQIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 163

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCCGATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGA CGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAAATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTG AGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGAAGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATA ACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGCGAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGC GATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGATAGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGG

:GCG< Table7(cont.)

GCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATCCGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGG CTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGAGTTCGACCCGACGAAGCACCGCTACGATGCGGAATACT ACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTCTAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTAC CAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAGGTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACA AAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGACCATCATCATCATCATCATTGA

SEQ ID NO: 164

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRQRPIKILANLDYRQRLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIR

TTRGLEIVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHV AVAKRLAARGVKIRPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRY QKTKQVGSGAWLKVKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 165

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 166

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYKGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table 7 (cont.)

DTDGLHATIPGADAETVKKKAKEFLKYINPICLPGLLELEYEGFYWGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAICETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 167

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTfCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 168

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 169

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC Table7(cont.)

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCσCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGATGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CCATCATCATCATCATCATTGA

SEQ ID NO: 170

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVICEPERGLWDNIVYLDFRSMYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 171

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA Table7(cont.)

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC σCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 172

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEJCVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSEYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 173

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 174

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

GPl^'iiMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 175 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCATTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CCATCATCATCATCATCATTGA

SEQ ID NO: 176

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSHYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 177

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC Table7(cont.)

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGGAGTATCCTTC

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGGTGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 178

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSEYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 179

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCAGATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACσCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table7(cont.)

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 180

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRQIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 181

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG fable7(cont.)

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 182

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGSYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 183 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 184

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSEYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI Table7(cont.)

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 185

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 186

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 187

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

CTTCGACCTCTACCCCGTCATAAGGC^'GC&CGJ-fAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGGCTCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 188

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWALLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 189

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCσCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC Table7(cont.)

GAGATAGCGAAGGAGACCCAGGCCAGGeTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 190

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWQLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 191

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAG

GTGAAGGGGAAGAAGGGTACCG;

CCATCATCATCATCATCATTGA

SEQ ID NO : 192

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV Table 7 (cont.)

ARYSMEDAKVTVELGREFFPMEAQL≤R^'Ll&ζjSi. WDVSRSSTGNLVEWSLLRKAYKRNEIiAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSI IITHNVSPDTLNREGCKE YDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 193

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

CCATCATCATCATCATCATTGA

SEQ ID NO: 194

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGMIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 195 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

!TTCC Table7(cont.)

TGGAOGeCGACGAC^XeCTtMCGAWdTCGeCtTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AGGccTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCGTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 196

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 197 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT Table7(cont.)

CCTCGCCAACAGCACCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 198

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 199 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACCTCAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCTATCCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID NO: 200

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYLRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFYPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 201

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 202

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYARNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 203 Table 7 (cont.)

ATGATTCfCGAfAd^'CόAdfA^'dATCXtddlAb'kλcδGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACGGAAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 204

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYGRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 205

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA Table7(cont.)

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGCGTCTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 206

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 207

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table7(cont.)

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 208

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRMWLIKILANSIYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 209 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 210

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNMVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

LEYE Table7(cont.)

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 211

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CCATCATCATCATCATCATTGA SEQ ID NO: 212

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLYKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 213

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA Table7(cont.)

CTCGffCAGGGACGGGAGCGAGCCGAAiGXTXeftOCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCTACCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 214

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSYLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* SEQ ID NO: 215

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA Table 7 (cont.)

AGAAGAAGTACGCTGTGATAGACGAδeASGσdAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC σCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 216

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPPEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 217 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 218 _;

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPICEKVyAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGLLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 219

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 220

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFQLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 221

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA Table7(cont.)

CCCCσClK3fCGTTGfi!CATrTACGAGϊΑfclSλ§ΑTACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCTGGCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 222

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFWLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 223

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCGAGCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG Table7(cont.)

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAG_ATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 224

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFELRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 225

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID NO: 226

MILDTDYITENGKPVIRVFKICENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFKLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 227

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCΪCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACσC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 228

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRVWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table7(cont.)

SEQ ID NO: 229

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCGCACTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT

CCATCATCATCATCATCATTGA

SEQ ID NO: 230

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATIiYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRALYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 231

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT Table7(cont.)

GAGGCTTATAGGCCArøGCCTCΪGGGACGTCfCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACGGTTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 232

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAE KVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDL YPVIRRTINLPTYTLEAVYEAVFGKP KE KVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKE YDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 233 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCTTCTACGGCCTTTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAQGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC Table7(cont.)

CGGCCeGGCACGGTGATAAGCTaCATCGftrC^rAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 234

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGLYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 235 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 236

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYQGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table 7 (cont.)

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 237

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCσCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 238

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 239 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC Table7(cont.)

TCAfCfeCCTACAACGCCGACAfiCTTCGftCUTfCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGATGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAG

GTGAAGGGGAAGAAGGGTACCσ;

CCATCATCATCATCATCATTGA

SEQ ID NO: 240

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVMWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 241

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ACGC Table7(cont.)

ATAUA^TIPTAlAfCCAAM'CTόCC^GeOTdfΛlj'GAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 242

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWCLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 243

CCATCATCATCATCATCATTGA

SEQ ID NO : 244

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

GPlLMrSYADGSEΑRVITWKKIDLPYVDVVS'ΪΕKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWHLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 245 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CCATCATCATCATCATCATTGA

SEQ ID NO: 246

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWYLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 247 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC Table7(cont.)

AGdCdGAfAGAGGTCTGGAAGCTCtAtWC^ACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCACGTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 248

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKWAKRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSTYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 249

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table7(cont.)

TTG6ACACAAGfϊdϊGCiAAyGA'e'τfC(!!'c'fc6GfcτTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACACTGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACσCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 250

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYTGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 251

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG Table 7 (cont.)

GTGSAGGdbMOMGGOTSCCGSAOCWVWfcG^AGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 252

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFYPSLLGDLLEERQK

IKRKMKATVR)PLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 253

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGTGGCTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 254

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKWLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI Table 7 (cont.)

RPdfV¹ΪSΛtπ_JkOSeMGβ^rP'A^]3g^^'rκ!kRyDAEYYIENQλ^LPAVERILKAFGYRKEDLRyQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 255

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO : 256

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPI EVWKLYFNHPQDVPAIRDRIRAHPAWD I YEYD I PFAKRYL IDKGL I PMEGDEELTMLAFAI ATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRWIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSII ITHNVSPDTLNREGCKE YDVAP EVGHKFCKDFPGFIPSLLGDLLEERQK IKRKM KATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

E IAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO : 257

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGTTCATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 258

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRFIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 259

ATGATTCTCGATACC

TAAAATCGAGTACG/

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCAACTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC Table7(cont.)

GAGATSGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC ΣCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCΣCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 260

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFQLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 261 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 262

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAE KVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATL YHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV Table7(cont.)

ARΫfeMEbAKVTYELGREFF&M-SΑQLg^'bLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSFYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 263

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 264

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLRGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 265

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA Table7(cont.)

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCATGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

CCATCATCATCATCATCATTGA

SEQ ID NO: 266

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLHGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT Table7(cont.)

CCTfcGCCAACAGCTTCTACGGCTACfACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACσC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 268

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPEEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLΈKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 269

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGTCAGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID NO: 270

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPSEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 271 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

CCATCATCATCATCATCATTGA SEQ ID NO: 272

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFILSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 273 Table 7 (cont.)

ATGATTCTCGATACCGACTACATCACCGAGA^VCGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 274

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAE KVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPA WDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATL YHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKE KVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEARLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPS IIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFI PSLLGDLLEERQK IKR KMKATVDPLEKKLL VYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHR YDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKL I S EEDLNS AVDHHHHHH*

SEQ ID NO : 275

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCTGGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA Table7(cont.)

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA SEQ ID NO: 276

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAWLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 277 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCτCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCTCTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table 7 (cont.)

GTTfcGACCCGACGAAGCACCGdΪACGATGCGGAATACTACATCGAGAACCAGC-lTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 278

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKE KVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKE YDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK I KRKMKATVDPLEKKLLVYRLWL I KILANS FYGYYGYAKARWYCKECAES VTAWGREY I EMVIRELEEKFGFKVL YA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 279

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CCATCATCATCATCATCATTGA SEQ ID NO: 280

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRFWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS Table7(cont.)

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 281

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 282

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRALYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 283

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA Table7(cont.)

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTCGTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 284

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGSYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 285 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCACATACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GAGT Table7(cont.)

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 286

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYPYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGTYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 287

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO : 288

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVT AKRHGTWKVKRAE KVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATL YHEGEEFGT

KRFI Table7(cont.)

LGRbGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGHYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 289

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 290

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGIYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 291 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA Table7(cont.)

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG CCTCGCCAACAGCTTCTACGGCATGTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CCATCATCATCATCATCATTGA

SEQ ID NO: 292

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGMYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 293 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ACC; Table7(cont.)

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 294

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLPDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* SEQ ID NO: 295

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCAGATAAAAAT

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID NO: 296

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLVYRQWQIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 297 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 298

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKALWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table7(cont.)

SEQ" ID NO: 299

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 300

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPPLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 301

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC Table7(cont.)

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCACTAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 302

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAE KVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATL YHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNL VEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSI I ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFI PSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 303

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC Table 7 (cont.)

CGGt&eifcGCi*A:c<5κ3T(5MAAGCTACS1'β3'!-"ceTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 304

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPS I I ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGKI PSLLGDLLEERQK

I KRKMKAT¹VDPLEKKLLDYRMWLIKI LANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 305

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 306

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

^ΓAKA] Table7(cont.)

DTDGLHATlPGAD^Wkk'l^KllttWΪWiPKliPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 307

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCσCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 308

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 309

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC Table7(cont.)

TC^CMCtTAdW^^dfefc'fekCAAt^Cbέϊiϊfef.TCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTC/.

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT

CCTCGCCAACAGCCACTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAG

GTGAAGGGGAAGAAGGGTACCG^

CCATCATCATCATCATCATTGA

SEQ ID NO: 310

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 311

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCσCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCGTGTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA Table 7 (cont.)

ATACΪAfϊAA't'CCAAAACTGClCCG'ϋd'CΪ&^'έ'Te&AACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 312

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAE KVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVD VVSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPS I I ITHNVSPDTLNREGCKE YDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 313

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

CCATCATCATCATCATCATTGA SEQ ID NO: 314

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

GPlfMSYkDG£&$^^

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAWEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRMWLIKILANSTYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 315

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 316

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFKPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 317

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC Table7(cont.)

AGGCCGOTAGAGCTCTGGSAGCTCTkeftCMcCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCTCACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

CCATCATCATCATCATCATTGA

SEQ ID NO: 318

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPyFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFSPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 319

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GCGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table 7 (cont.)

TTGGACACAAGTTCTGCAAGGACTTCeCeGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA SEQ ID NO: 320

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRSAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSI I ITHNVSPDTLNREGCKE YDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 321 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGbcAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC Table7(cont.)

GTGAAGGGGAAGAAGGGTACCGAAGCTTA^'CGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 322

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYLRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 323

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 324

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYGRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI Table7(cont.)

RPGI¹VISYiVLKGSGRIGDRAIPADEE¹IDPfKJiRYDAEYYIENQVLPAVERiLKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 325

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CCATCATCATCATCATCATTGA

SEQ ID NO: 326

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 327 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATACACCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA

SEQ ID NO: 328

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 329

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC Table7(cont.)

GAG^TAGCGAAGGAGACCCAGGCCAGδGffdfTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 330

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 331

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA

SEQ ID NO : 332

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAE KVQKKFLG RPI EVWKLYFNHPQDVPAI RDRI RAHPAWD I YEYD I PFAKRYL IDKGL I PMEGDEELTMLAFAI ATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV Table7(cont.)

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNL¹VEWFLLRKAyKRNELAPNKPDERELARRRGGyA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 333

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CCATCATCATCATCATCATTGA SEQ ID NO: 334

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNHVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 335

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA Table7(cont.)

TGGAiSdGCOACGAGCAGCTtACGATGCfC(SCCi¹TTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAG

GTGAAGGGGAAGAAGGGTACCGP

CCATCATCATCATCATCATTGA

SEQ ID NO: 336

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFICSLLGDLLEERQK IKRKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 337

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT Table7(cont.)

CCTeGCCA^CAISCTTCTAeGSCI¹ACTKCiSGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 338

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEASLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 339

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ^"ID NO: 340

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERDK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 341

ATGATTCTCGATACC TAAAATCGAGTACG; AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CCATCATCATCATCATCATTGA SEQ ID NO: 342

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEKQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 343 Table7(cont.)

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGCCACAGAAG CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA

SEQ ID NO: 344

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPA WDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKI QRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKE KVY AEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSI I ITHNVSPDTLNREGCKE YDVAPEVGHKFCKDFPGFIPSLLGDLLEEPQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 345 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA Table7(cont.)

AGGtfCl%CAAGAG^'6^CGffiCTCt5Ct:eeMft<SAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGTCCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 346

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEVQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 347

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table7(cont.)

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 348

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEELQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 349

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 350

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEGQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS Table 7 (cont.)

EIAKETQAR VLEAILKHGDVEEAVR'IVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKL I S EEDLNS AVDHHHHHH *

SEQ ID NO: 351

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 352

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 353 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA Table7(cont.)

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAAAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACACGGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 354

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 355

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCTTCTACGGCTACCAAGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA Table 7 (cont.)

AGAAGAAGTACGCTGTGATAGACGAGGAGGC-ΪCAAσATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 356

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IKRKMKATVDPLEKKLLDYRMWLIKILANSFYGYQGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 357 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

CCTCACTAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 358

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

LGRϋbS'te^KlORl^Dft&AV^VKGliflSyβϊΫP^RRTINLPTYTLEAλryEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILTNSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 359 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 360

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVAAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 361 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCσCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA Table7(cont.)

CCCiGCTGtCGTTdSGSTCtACGAGfftCGACfiTACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGCCGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA

SEQ ID NO: 362

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVPAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 363

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG Table7(cont.)

ATAdkGCGGAAGATGMGGCiu^iSόGΪfd^dCdGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 364

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAKLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 365

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table 7 (cont.)

SEQ ID NO : 366

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVT AKRHGTWKVKRAE KVQKKPLG

_RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT _LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV _ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEASLLRKAYKRNELAPNKPDERELARRRGGYA G_GYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* SEQ ID NO: 367

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 368

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAELLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table7(cont.)

SEQ ^"ID NO: 369

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

CCATCATCATCATCATCATTGA SEQ ID NO: 370

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSVYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 371

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT Table 7 (cont.)

GAGdCtΪATAGGCCAGAGCCTCTδG'GKfcGtCΪCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCTGGTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 372

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAI EDVKKVTAKRHGTWKVKRAE KVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKE KVYAEE IAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPS I I ITHNVS PDTLNREGCKEYDVAPEVGHKFCKDFPWF I PSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKAR WYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHR YDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 373

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCAGTCCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCCACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC Table7(cont.)

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 374

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFSPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGHYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 375

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAGTCAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCσCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 376

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIVILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table 7 (cont.)

DTDGLHATIPGADAETVKKKAKB^LRtIMIJICI-¹PGLLELEYEGFYVRGFFVTKKKYAViDEEGKITTRGLEiVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 377

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 378

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIYILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 379

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA Table7(cont.)

TCATCACCTACAACGOCCSCi^ACT^TCUS^fcttuacCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATATGGAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAA'TC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 380

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIWILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 381

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC Table7(cont.)

ATACATTMT^'CCSA^etGtCCGOCCtOi-rtCClAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 382

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVICRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 383

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGGAGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 384

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSEYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 385

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA SEQ ID NO: 386

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSHYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVOSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 387

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC Table7(cont.)

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 388

MILDTDYITENGKPVIRVFKKENGEFKI EYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAE KVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYE YDIPFAKR YLIDKGLI PMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKE KVY AEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSMYPS I I ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKM KATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO : 389

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGGCATATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table7(cont.)

TTGGACACAAGTTCTGCMGGACTTCCm-GeTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCPTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 390

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSAYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 391 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGAACTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG Table7(cont.)

GTGAAGGGGAAGAAGGGTXCCGAAGeTT⁸A¹CiGT¹AGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 392

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSNYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 393

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 394

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSKYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI Table 7 (cont.)

RPGTV rSΥIVLKGSGRTGDRAIPADE^'PβP^'TrøRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKL I S EEDLNS AVDHHHHHH *

SEQ ID NO: 395

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA SEQ ID NO: 396

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSYYPS 11 ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 397

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

CTTCGACCTCTACCCCGfCATAΛGibdb^'t!Α⁽!.6A*AAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGCTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 398

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSCYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 399 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCAATATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC Table7(cont.)

GAGA^Aδfcd^GδAtiA^eidGCdAdddW'TTΑGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 400

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSQYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 401

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCTACCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACσC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 402

M I LDTDYI TENGKP VI RVFKKENGE FKI E YDRTFEP YF YALLKDDS AI ED VKKVTAKRHGT WKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATL YHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV Table7(cont.)

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSYLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 403

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 404

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFLGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 405

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA Table7(cont.)

TGGXbdSCcSAdGSGcSAeeftACGATOWddfcCrtTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCAACGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCσCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 406

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFNGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 407

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT Table7(cont.)

CCTCGCCAACAGCTTCTACOGCTACTAeGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 408

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERYK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 409

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGCTGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ IU NO: 410

MILDTDYITENGKPVIRVF-OCENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IERKMKATTDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 411

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCTTCTACGGCCATTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 412

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRI-HFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGHYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 413 Table7(cont.)

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCGTGTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CCATCATCATCATCATCATTGA

SEQ ID NO: 414

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 415

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA Table7(cont.)

AGGCCTXcAAGAe^'GSAOiSl&^'CTCiScfcό^'CAώiLCΪAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGσCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCATCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 416

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 417

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCσCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCCACTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table7(cont.)

GTTCGACCCGACGAAGCACCGCTACGATGCGeAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 418

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSHYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 419

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATGACGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 420

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNDVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS Table7(cont.)

EIAI^QAI^EA'itLΪd-GB^^

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 421

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGGCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCCGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 422

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAPLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 423

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA Table7(cont.)

CTCGGCAGGGACGGGAGCGAGCCGAAGATACA'GCGAATGGGCOACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCCGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATACCTCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 424

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMIiAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAPLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 425

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCGATCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA Table 7 (cont.)

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 426

MILDTDYITENGKPVIRVPKKENGEFKIEYDRTFEPYFyALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEADLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 427 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCACACTTTC

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO : 428

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

KRFL Table7(cont.)

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEATLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 429

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 430

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAVLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 431

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA Table7(cont.)

CCCdGCΪfGtC^'GTΪG^cXϊd^ACiSλGT&tirGiC^TACCCTTCGCCAAGCGCTACCTCATCGACAAGGσCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 432

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERLK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 433

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGTCAAAG Table7(cont.)

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 434

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVK-CVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRIJAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 435

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGGTAAAG CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID NO: 436

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKOTA1<_RHGTWICVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERVK

IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 437

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGGACAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 438

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERDK

IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table7(cont.)

SEQ ID NO: 439

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGGTCAGAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 440

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEGQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 441

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC Table7(cont.)

GAGGCTTAfAGeCCAiSXfeeiiTCTOGfeXU^CfCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGCCGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 442

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMIfJYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEPQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 443 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAAACAGAAG CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC Table7(cont.)

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 444

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEKQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 445

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCσCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 446

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEESQK IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table 7 (cont.)

DTDGIIHATIPGADABTVKKKAKEFLKYIKPKIIPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKL I S EEDLNSAVDHHHHHH *

SEQ ID NO: 447

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG CCTCGCCAACAGCTTCTACGGCTACAGTGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 448

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYSGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVσSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 449

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC Table7(cont.)

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGQAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACσCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACACAGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 450

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 451

CCCCσCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCCTTTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA Table7(cont.)

ATACATTAATCCAAAACTGCCCGGCCT⁽SUtCSAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCσCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 452

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSLYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 453

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCσCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 454

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSCYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 455

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCATCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 456

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSIYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 457

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

U3GT< Table7(cont.)

AGGCOGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCCATTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 458

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSHYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 459

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table 7 (cont.)

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCACCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 460

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSTYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 461

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCGTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG Table 7 (cont.)

CCATCATCATCATCATCATTGA

SEQ ID NO : 462

MILDTDYITENGKPVIRVFKICENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSVYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 463

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCTGTCTTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 464

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEACLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI Table 7 (cont.)

RPGTVlSYlVLKtfSdRYGDl&rPADEFDPTKHRYD AEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 465

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 466

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEASLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 467

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

CTTtCGACdtCTAUCCOOTdATAAtfSCdtfAitGlkTAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCGACCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCσCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 468

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEADLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 469 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC Table7(cont.)

GAGATAGCGAAdGAGXtfdC^^

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCσCGGCGCGTGGAGTGAAAATC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 470

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAICRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAPLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 471

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 472

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV Table7(cont.)

ARYSMBDAKVTtfβEQI^KFPMEALΪiδ^

GGYVKEPERGLWDNIVYLDFRSWYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 473

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACσCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCσCCCCTGAGG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 474

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERAK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 475

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA Table7(cont.)

TGG.^3⁽^C⁽3ACdft^W⁽3CWACGATG^⁽!S;i3CG!TTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA SEQ ID NO: 476

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 477 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGCCCCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT Table7(cont.)

CCTCXSCG-AAICAG(STTOTAGGGCTACTACUOOGaPACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 478

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEPQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 479

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAG.CCCGACGAGAGGGAGCTCGCGAOACGGCGCGGGGGCTACGCT

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

GTGAAGGGGAAGAAGGGTACCG;

CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ΪD NO: 480

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMIiAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEKQK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 481 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 482

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEESQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTviSYivLKGSGRiGDRAiPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 483 Table 7 (cont.)

ATGAΪT^CfeATAdCXSACAteATfiidC^ffiy^ACGGGAAGCCCGTGATAAGGGTCTTCAAσAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGGGCAGAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 484

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVT AKRHGTWKVKRAE KVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVWEKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEE IAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEGQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 485 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA Table7(cont.)

AGGCCTACAAGAG&UΪC<3A<$CTCX^

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CCTCGCCAACAGCTTCTACGGCTACACAGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 486

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK lERKMKATVDPLEKKLLVYRQWLIKILANSFYGYTGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 487

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACATGGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACσC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table 7 (cont.)

GTTCC3ACCCGACGfelAGCACC⁽3CTftC©A1?GlSeeΑATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 488

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVWEKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYMGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 489

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 490

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYLGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS Table 7 (cont.)

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKL I SEEDLNS AVDHHHHHH *

SEQ ID NO: 491

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CCTCGCCAACAGCTTCTACGGCTACAGTGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 492

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYSGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 493

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA Table7(cont.)

CTCGUCAGGGAC^Qft(M(3AG^'ce«Md-MISdAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTACGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 494

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNYVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 495

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA Table7(cont.)

AGAAGAAGΪACGiΞΦG-T(5AΦAG^'A(S<5Ae(SM(3βΘAAGATAACCACGAGGGGTCTTGAσATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 496

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNQVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 497 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO : 498

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPI EVWKLYFNHPQDVPAI RDR IRAHPAWD I YE YD I PFAKRYL I DKGL I PMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVWEKDPDVLITYNGDNFDFAYLKKRCEELGIKFT Table7(cont.)

LGRD<fSI.PKΪQRtfGb#E^

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNYVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSVYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 499

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

CAGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 500

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVT AKRHGTWKVKRAE KVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNYVEWFLLRSAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 501

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA Table7(cont.)

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTACGTGGAGTGGTTCCTCCTGCGGG ACGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

CCATCATCATCATCATCATTGA SEQ ID NO: 502

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNYVEWFLLRDAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 503

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTACGTGGAGTGGTTCCTCCTGCGGA TGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG Table7(cont.)

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 504

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNYVEWFLLRMAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 505

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTACGTGGAGTGGTTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCσCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table 7 (cont.)

SEQ ID NO : 506

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPI EVWKLYFNHPQDVPAI RDR IRAHPAWD I YE YD I PFAKRYLIDKGL I PMEGDEELTMLAFAI ATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPV_IRR_TINL_PTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEALLSRLIGQSLWDVSRSSTGNYVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKL I S EEDLNSAVDHHHHHH *

SEQ ID NO : 507

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTACGTGGAGTGGTTCCTCCTGCGGA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA

SEQ ID NO: 508

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEATLSRLIGQSLWDVSRSSTGNYVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table7(cont.)

SEQ ΪD NO: 509

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCGTGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 510

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAVLSRLIGQSLWDVSRSSTGNYVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 511 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCGACCTTTC Table7(cont.)

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCσCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCσCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 512

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEADLSRLIGQSLWDVSRSSTGNYVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 513

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTACGTGGAGTGGTTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAAGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC Table7(cont.)

CGGCCCGGCACGGϊGAΪAAόCTACAteόfCΪCtAAAQGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 514

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNYVEWFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEKQK

IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 515

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTACGTGGAGTGGTTCCTCCTGCGGA

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG CCTCGCCAACAGCTTCTACGGCTACACGGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 516

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNYVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSFYGYTGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table 7 (cont.)

DTDβLIffiTI PGABXE WadCAK^ EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRIJAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 517

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 518

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSVYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 519

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC Table7(cont.)

TCATCACCTACMCGGCfiACAAC'ΪTeGAC'tTCΪGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCATCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 520

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERSK IERKMKATVDPLEKKLLVYRQWLIKILANSIYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 521 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA Table 7 (cont.)

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 522

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSAYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 523 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGC

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 524

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

GPIIJMISYADGSE^RVrTWKKIDIl'PYVD^ArsTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRRAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERSK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 525

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCσCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGC GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 526

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRLAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERSK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 527

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACσCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC Table7(cont.)

AGGCCGATAGAGGTCTCS^'GJiAOCf^'CTAdTl'eMCCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGG TGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 528

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRVAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 529

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

CGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

AATCATCATAACCCACAACGTCTCσCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table7(cont.)

TTGGACAO^GTTCtGCMSGACfTCCCddlSCitTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 530

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRTAYKRNELAPNKPDERELARRRGGYA

IERKMKA¹TVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 531

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

CAGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC Table7(cont.)

GTGAAGGGGAAGAAGGGTACCGAAGCffASdi AGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 532

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRAAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERSK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 533

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 534

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERSK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYQGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI Table 7 (cont.)

RPGTVISYIVLKGSGRrcSDl^IP^βrøWlMRYDAEyYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 535

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 536

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNSVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 537 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

CTTCόACCTCTACCύϋdfiC^AAG'όCGCkfcδK't'AAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCGACCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 538

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEADLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 539 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCσCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC Table7(cont.)

GAGATAGCGAAGGAGACCόΑόGd^'eAόG^'QT^'eiWAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 540

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEACLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERSK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 541

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCσCCCCTGAGG

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO : 542

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATIJ YHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV Table7(cont.)

ARYSMEDAKVTYEI-GKE^FΒMEAHLSRT'ΪD'OSLWDVSRSSTGNLVEAFLLRKAYKIMEIAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERSK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 543

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCσCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 544

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEATLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 545

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA Table7(cont.)

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCCCCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAG

GTGAAGGGGAAGAAGGGTACCGiS

CCATCATCATCATCATCATTGA

SEQ ID NO: 546

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAPLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 547

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCTTCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT Table7(cont.)

CCTCGCCAACAGCTTCTACGGCTACTACdCSU¹I¹ACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 548 MILDTDYITENGKPVIRVFKKENGEPKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPiEvwKLYFNHPQDVPAiRDRiRAHPAVVDiYEYDiPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEALLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDEREIIARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 549

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGCAAAGCAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID^"NO^": ^"5S¹B

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEQSK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 551

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAG

GTGAAGGGGAAGAAGGGTACCG^

CCATCATCATCATCATCATTGA

SEQ ID NO: 552

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 553 Table7(cont.)

ATGAlTCJTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGGCAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 554

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVWEKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEGSK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 555

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

:τcGi Table7(cont.)

AGGCCTACΛAGAGGMCeAlόCTCCΪCόάciiώiftdkAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGATGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 556

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 557 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCσCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

CCTCGCCAACAGCTTCTACGGCTACATGGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table 7 (cont.)

GTTCGACCCGACGAAeGACiCOCTSCOATGIUG⁽SAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 558

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERSK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYMGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 559 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 560

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSILGDLLEERSK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYLGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS Table 7 (cont.)

EIAKETQΪ^RVLEAILiαiGϋVESAVRΪVKΪ^VTBΪCLSKYEVPPEKLVIHEQITRDLRDyKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHR YDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKL I SEEDLNSAVDHHHHHH *

SEQ ID NO: 561

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA

SEQ ID NO: 562

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYKGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 563

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA Table7(cont.)

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCσCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACCTAGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 564

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERSK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYLGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 565 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACACAGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA Table7(cont.)

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 566

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERSK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYTGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 567

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 568

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT Table7(cont.)

LGiωόSE&KlQRMeDRF'XVEiVKG^lliF'D'L'ΫWΪRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 569

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG CCTCGCCAACAGCCATTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CCATCATCATCATCATCATTGA

SEQ ID NO: 570

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNYVEWFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK IERKMKATVDPLEKKLLDYRMWLIKILANSHYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 571

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA Table7(cont.)

CCCCGCTGTCGTTGACAfCfXCGAGtAcϊό^CiiTACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTACGTGGAGTGGTTCCTCCTGCGGA CCGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGAGGCAGAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGATTACAGGATGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 572

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNYVEWFLLRTAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEERQK

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 573

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG Table7(cont.)

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAGCAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 574

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLISILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* .

SEQ ID NO: 575

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCσCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAATCAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

GTGAAGGGGAAGAAGGGTACCG;

CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID NO: 576

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIIILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 577

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAG

GTGAAGGGGAAGAAGGGTACCG^

CCATCATCATCATCATCATTGA

SEQ ID NO: 578

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLILILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table7(cont.)

SEQ ^"ID NO: 579

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAACTAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 580

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLITILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 581

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC Table7(cont.)

GAGGCTTATAGGCCAGAGCCTCTGGGAICdTC'I'CGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATACATAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 582

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYPYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIHILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 583 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATATGTAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC Table7(cont.)

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 584

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLICILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 585 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 586

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIFILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table 7 (cont.)

EIAKETQARVLEAILKHGDVEEAWIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 587

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCσCTTCCTCCσCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATACGGAT

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 588

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIRILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 589

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC Table7(cont.)

TCATCArcmCAACGGCdΑdMCΦTOGACΪTteGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATACAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA

SEQ ID NO: 590

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIQILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 591

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATACCAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCσCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA Table7(cont.)

ATACATTAATCCAMΑCTGCt^'CGGtdTddϊCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCσCACGTTGCCGTTGCGAAGAGGCTCσCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 592

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKWAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIPILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 593

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 594

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

GPILMl≤YAbόSfiΑRVrTWIQCΪDlil'YWWSTέKEMIKEFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIWILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 595

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAGCTAT CCTCσCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCσCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 596

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIAILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 597

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC Table7(cont.)

AGGCfcGM^bAGdϊόϊά^'dA.iόCTdTl^WAAfcCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAGAAAT

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 598

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIEILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 599

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table7(cont.)

TTGGACACAAGTf^tG^AA^GACTT^

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAGTAAT

CCTCσCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 600

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIVILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 601 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG Table 7 (cont.)

GTGAΑGtSGGAAGMGCόfsdCGA^GdiffiidGfXGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 602

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMIiAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIYILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVisYiVLKGSGRiGDRAiPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 603 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 604

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIMILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI Table7(cont.)

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 605

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAGGTAT

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 606

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIGILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 607

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

CTTCd!ACfcTdTA<ϊbtcl!3¥fcAΪAAΘfeC^⁽SλΘ§AiAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCACGAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCσCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 608

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILATSFYGYYOYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 609 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG CCTCGCCGATAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC Table 7 (cont.)

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCσCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 610

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMIiAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILADSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 611 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 612

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV Table7(cont.)

GGYVKEPERGLWDNIVYLDFRSWYPS11ITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILAFSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 613

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAGAAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 614

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMIiAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILARSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 615 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA Table7(cont.)

TGGAGGGCGACGAGGAGCtfAtGStGOfeOticrfTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCσCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCGGCAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

CCATCATCATCATCATCATTGA

SEQ ID NO: 616

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILAGSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 617

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT Table7(cont.)

CCTCGCCTTGAGCTTCfΑC^'όGCfΑC'ϊ'iϊCfd CT'ACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACσC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 618

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILALSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 619 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID NO^": ^"620

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILAISFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 621

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCσCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 622

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILAASFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 623 Table7(cont.)

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 624

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILACSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 625

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA Table7(cont.)

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAAAAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 626

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILAKSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 627

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCCAGAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table 7 (cont.)

GTTCGACCCGACGAAGCACCGCTA^'CGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 628

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILAQSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 629

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CCATCATCATCATCATCATTGA SEQ ID NO: 630

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILAVSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS Table 7 (cont.)

EIAKETQARVLEAILKHGDVEEA^ΪVKSVTE.aSKYEVPPEKLVIHEQITRDLRDYKATGPI.VAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

£3EQ ID NO : 631

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCΣCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG CCTCGCCGAGAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 632

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILAESFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 633 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA Table7(cont.)

CTCGdCAeGόACGiSδSGCGSGCCαΑAδATftCAσCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCATGAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 634

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILAMSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 635 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA Table7(cont.)

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 636

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILASSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 637

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

CCTCGCCTGGAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 638

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT Table7(cont.)

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLΫPVΪRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILAWSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 639

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG CCTCGCCCCGAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA SEQ ID NO: 640

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMIIAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILAPSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 641

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA Table7(cont.)

CCCCGCTOTOdTTCSACAftTACGAfel'AtOACA'i'ACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACσCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCTACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CCATCATCATCATCATCATTGA

SEQ ID NO: 642

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILAYSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 643 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG Table7(cont.)

CCTCGCCCACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 644

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA lERKMKATVDPLEKKLLVYRQWLIKILAHSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 645

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGAGCCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID NO: 646

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKPLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWSPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 647

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 648 '

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table 7 (cont.)

SEQ ID NO : " ^49'"

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGAAGCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 650

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWKPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 651

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC Table7(cont.)

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGCAACCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 652

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWQPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 653

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACσCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC Table7(cont.)

CGGCCCGGCACGGTGATAAGCTACATCdItC¹CI¹A-^AGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 654

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWWPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 655

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 656

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table7(cont.)

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEPDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 657

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 658

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWEPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 659

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC Table7(cont.)

TCATClCCΪTAέAACJ^Iai^Αti^C^'TTfiftΛWTlSόicTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGACCCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO : 660

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAE KVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKR YLIDKGLIPMEGDEELTMLAFAIATL YHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 661

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGAGGCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC Table7(cont.)

ATACATTAATCCAAAACTGCtCGGCCtdCiffCtealkcTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 662

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 663

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 664

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKR YLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

GPILMlsVADGSEAWiTteMDLP

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWLPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 665

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGA^'CCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTGCCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 666

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWCPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 667 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA Table7(cont.)

AGGC^Gkt^biG^CfOdAioCTdfiifWBi^bCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGGTGCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CCATCATCATCATCATCATTGA SEQ ID NO: 668

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 669

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGCCACCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table7(cont.)

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 670

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 671

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG Table7(cont.)

CCATCATCATCATCATCATTGA

SEQ ID NO: 672

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAKKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWGPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 673 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 674

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWMPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI Table 7 (cont.)

RPGrVrSYIVLKσ-SGKΪGDRAIPADEPDPtKSRYDAEYYIENQVLPAVKRILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 675

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGATCCCTTC TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 676

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWIPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 677

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCσCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCσCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTTTCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 678

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 679

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGGACCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC Table 7 (cont.)

GAGiϊϊAσCδAAC^ACΪΛ^dΑόGeCΑGCS^ΪtJT't'AGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 680

MILDTDYITENGKPVIRVPKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLK-KRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 681 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCATCGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 682

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV Table7(cont.)

ARYM-tøAKVTΫtøiG^'KElFFiPMBA^'Φ^^^

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTTJNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMICATVDPLEKKLLVYRQWLIKILANSFIGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 683

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG CCTCGCCAACAGCTTCTGGGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 684

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFWGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 685

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA Table7(cont.)

TGG^CSGGCGACOAGΘAGGTTAGβATGeTGGGCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

CCTCGCCAACAGCTTCCGTGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 686

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFRGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 687 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT Table7(cont.)

CCTdGdCAAcAddWi^bdbOCTlKS^AtGfectACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 688

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFPGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 689 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID¹¹WO¹: '69O'

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFVGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 691

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 692

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFNGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 693 Table7(cont.)

ATGAΪT^TCGAl'kCCiSAfcTACATeAeόCSACilAϊL'CGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

CCTCGCCAACAGCTTCAGCGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 694

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFSGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 695

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA Table7(cont.)

AGGCt:TAeiUV6A(3^'6iiAd(3Ai3CTCl3^'CCCCASAcAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCGGGGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

CCATCATCATCATCATCATTGA

SEQ ID NO: 696

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDEREIiARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFGGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 697

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT GGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCσCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA Table7(cont.)

GTTC^fcCdGΑC&MδδACέόCΪ^CόA^dtfσdλATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 698

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFLGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 699

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAG

GTGAAGGGGAAGAAGGGTACCG?

CCATCATCATCATCATCATTGA

SEQ ID NO: 700

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFTGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table 7 (cont.)

EIAKfcTQMvLEAtLimGDVEEAVRlVKEWgKLSKYEVPPEK^^

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 701

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCATGGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 702

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFMGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 703

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA Table7(cont.)

CTCdbcl^Gkcd^'GGAO^'&G^GCCGAAO^f^C^GCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCGCTGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACσCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 704

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA lERKMKATVDPLEKKLLVYRQWLIKILANSFAGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 705

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCGAGGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA Table7(cont.)

AGAAβAAGTAeGCTOTCMΪAOA∞AαOAlG^eΑAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 706

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKICVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDVVSTEKEMIKRFLRVVREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFEGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 707

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCAAGGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA

SEQ ID NO: 708

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT Table7(cont.)

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFKGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 709

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 710

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFCGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 711

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA Table7(cont.)

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCCACGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCσCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 712

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFHGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 713

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGOAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table7(cont.)

ATAGaI(SSCMAAO-MJSaB^

CCTCGCCAACAGCTTCGATGGCTACTACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 714

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFDGYYGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 715

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG CCTCGCCAACAGCTTCTACGGCTACTTTGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

GTGAAGGGGAAGAAGGGTACCGi!

CCATCATCATCATCATCATTGA Table7(cont.)

SEQ ID NO: 716

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYFGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 717

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 718

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYQGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH* Table 7 (cont.)

SEQ ΪD "'NO^i!: - 1 ±$ '

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

CCTCGCCAACAGCTTCTACGGCTACATTGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG CCATCATCATCATCATCATTGA

SEQ ID NO: 720

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYIGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI

RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 721 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC Table7(cont.)

GAGGISTtAfAOGtCAeMCdTCTGGeACIGT¹CYtGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACCGTGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 722

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYRGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 723 TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC Table7(cont.)

CGGCec^CΑCGόfGΛfSAβCTACΑTC^βTiødΦAAAGσGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 724

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYAGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK

VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 725 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 726

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV

ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYNGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA Table 7 (cont.)

DTDGLHATIPGAI^TVI&I&^Ft^

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGWISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKL I SEEDLNS AVDHHHHHH *

SEQ ID NO: 727

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCσCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 728

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYSGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 729 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA Table7(cont.)

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAG^QTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACACTGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 730

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYTGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 731

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACCATGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA Table7(cont.)

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

TAAAAGCCfTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 732

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYHGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 733

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

CCATCATCATCATCATCATTGA

SEQ ID NO : 734

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKR YLIDKGLIPMEGDEELTMLAFAIATL YHEGEEFGT Table7(cont.)

GPILMISYADGSEARVlWKKIDiLF^

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDEREIiARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYGGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 735

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 736

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYWGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 737

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC Table7(cont.)

AGGC(!GA^AGAGG¥cfteGM^T(&Ae*T<^

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG

TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT

CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

CCATCATCATCATCATCATTGA

SEQ ID NO: 738

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKI⁾DSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRVWEKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYLGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 739

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG Table7(cont.)

TTGGA&ACAiGl'frrG'd^ΘfeACTrøfciCci^SϊTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACCCCGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 740

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA

IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYPGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 741

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCσCTGTGAGGAACTCGGAATAAAGTTCACA CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC

GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC Table 7 (cont.)

GTGi^GteGOAAGMGUftfAeGGAAGeffAeGT^GAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 742

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT GPILMISYADGSEARVITWKKIDLPYVDWSTEKEMIKRFLRWREKDPDVLITYNGDNFDFAYLKKRCEELGIKFT LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYKGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 743

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA

GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG

CCATCATCATCATCATCATTGA SEQ ID NO: 744

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYVGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA DTDGLHATIPGADAETVKKKAKEFLKYINPKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWS EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI Table 7 (cont.)

RPGWΪSYΪVLKGiSGR'ΪGD&AI PADEPDPΪKSΕ YD AE YYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 745

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

CTTCGACCTCTACCCCGTCATAAGGCGCACGATAAACCTCCCGACCTACACCCTTGAGGCCGTTTACGAGGCCGTCT

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT

GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT

AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACGACGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA

GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 746

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG

RPIEWKLYFNHPQDVPAIPJ⁾RIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYDGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 747

ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

TAAAATCGAGTACGACAGAACCTTCGAGCCCTACTTCTACGCCCTTCTGAAGGACGATTCTGCGATAGAGGACGTCA

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC

AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA

CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA

TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC

GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA

CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

TCATCACCTACAACGGCGACAACTTCGACTTCGCCTACCTGAAGAAGCGCTGTGAGGAACTCGGAATAAAGTTCACA

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA Table7(cont.)

TTGGAAAGCCCAAGGAGAAGGTTTACGCAQAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA AGGCCTACAAGAGGAACGAGCTCGCCCCAAACAAGCCCGACGAGAGGGAGCTCGCGAGACGGCGCGGGGGCTACGCT GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG ATAGAGCGGAAGATGAAGGCAACGGTTGACCCGCTGGAGAAGAAACTCCTCGTGTACAGGCAGTGGCTTATAAAAAT CCTCGCCAACAGCTTCTACGGCTACTGCGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA CGGCCTGGGGAAGGGAGTATATAGAAATGGTTATCCGGGAACTCGAAGAAAAATTCGGTTTTAAAGTTCTCTATGCC GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGCCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC

GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO: 748

MILDTDyiTENGKPVIRVFKKENGEFKIEYDRTFEPyFYALLKDDSAIEDVKKVTAKRHGTWKVKRAEKVQKKFLG RPIEVWKLYFNHPQDVPAIRDRIRAHPAWDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATLYHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEEIAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GGYVKEPERGLWDNIVYLDFRSWYPSIIITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYCGYAKARWYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKLISEEDLNSAVDHHHHHH*

SEQ ID NO: 749 ATGATTCTCGATACCGACTACATCACCGAGAACGGGAAGCCCGTGATAAGGGTCTTCAAGAAGGAGAACGGCGAGTT

AGAAGGTAACCGCAAAGAGGCACGGAACGGTTGTCAAGGTGAAGCGCGCCGAGAAGGTGCAGAAGAAGTTCCTCGGC AGGCCGATAGAGGTCTGGAAGCTCTACTTCAACCATCCTCAGGACGTCCCGGCGATTCGAGACAGGATACGCGCCCA CCCCGCTGTCGTTGACATCTACGAGTACGACATACCCTTCGCCAAGCGCTACCTCATCGACAAGGGCCTGATTCCGA TGGAGGGCGACGAGGAGCTTACGATGCTCGCCTTCGCGATCGCAACCCTCTATCACGAGGGCGAGGAGTTCGGAACC GGGCCGATTCTCATGATAAGCTACGCCGACGGGAGCGAGGCGAGGGTGATAACCTGGAAGAAGATTGACCTTCCGTA CGTTGACGTCGTCTCGACCGAGAAGGAGATGATTAAGCGCTTCCTCCGCGTCGTCAGGGAGAAGGACCCCGACGTGC

CTCGGCAGGGACGGGAGCGAGCCGAAGATACAGCGAATGGGCGACCGCTTTGCCGTTGAGGTGAAGGGCAGGATTCA

TTGGAAAGCCCAAGGAGAAGGTTTACGCAGAGGAGATAGCGCAGGCCTGGGAGAGCGGGGAGGGCCTTGAAAGGGTT GCAAGATACTCGATGGAGGACGCTAAGGTGACCTACGAGCTGGGAAGGGAGTTCTTCCCGATGGAGGCCCAGCTTTC GAGGCTTATAGGCCAGAGCCTCTGGGACGTCTCGCGCTCGAGCACCGGAAATTTGGTGGAGGCATTCCTCCTGCGGA

GGCGGGTACGTTAAGGAACCAGAGCGGGGATTGTGGGACAACATTGTGTATTTAGACTTCCGCTCGTGGTATCCTTC AATCATCATAACCCACAACGTCTCGCCGGATACCCTCAACCGCGAGGGCTGTAAAGAGTACGACGTCGCCCCTGAGG TTGGACACAAGTTCTGCAAGGACTTCCCCGGCTTCATACCAAGCCTCCTGGGAGATTTGCTCGAGGAGGCGAGCAAG

CCTCGCCAACAGCTTCTACGGCTACATGGGCTACGCCAAGGCCCGGTGGTACTGCAAGGAGTGCGCCGAGAGCGTTA

GATACAGACGGTCTCCATGCTACCATTCCCGGAGCAGACGCTGAAACAGTCAAGAAAAAAGCAAAGGAGTTCTTAAA ATACATTAATCCAAAACTGCCCGGCCTGCTCGAACTTGAGTACGAGGGCTTCTACGTGAGGGGCTTCTTCGTCACGA AGAAGAAGTACGCTGTGATAGACGAGGAGGGCAAGATAACCACGAGGGGTCTTGAGATTGTGAGGCGCGACTGGAGC GAGATAGCGAAGGAGACCCAGGeCAGGGTCTTAGAGGCGATACTCAAGCACGGTGACGTCGAGGAGGCCGTTAGGAT AGTCAAGGAAGTGACGGAAAAGCTGAGCAAGTATGAGGTCCCGCCCGAGAAGCTGGTAATCCACGAGCAGATAACGC GCGATTTGAGGGATTACAAAGCCACCGGCCCGCACGTTGCCGTTGCGAAGAGGCTCGCGGCGCGTGGAGTGAAAATC CGGCCCGGCACGGTGATAAGCTACATCGTCCTAAAGGGCTCTGGAAGGATAGGCGACAGGGCGATTCCAGCTGATGA GTTCGACCCGACGAAGCACCGCTACGATGCGGAATACTACATCGAGAACCAGGTTCTCCCGGCGGTGGAGAGGATTC TAAAAGCCTTCGGCTATCGGAAGGAGGATTTGCGCTACCAGAAGACGAAGCAGGTCGGCTCGGGCGCGTGGCTGAAG GTGAAGGGGAAGAAGGGTACCGAAGCTTACGTAGAACAAAAACTCATCTCAGAAGAGGATCTGAATAGCGCCGTCGA CCATCATCATCATCATCATTGA

SEQ ID NO : 750

MILDTDYITENGKPVIRVFKKENGEFKIEYDRTFEPYFYALLKDDSAIEDVKKVTAKRHGTVVKVKRAEKVQKKFLG RPIEWKLYFNHPQDVPAIRDRIRAHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELTMLAFAIATL YHEGEEFGT

LGRDGSEPKIQRMGDRFAVEVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGKPKEKVYAEE IAQAWESGEGLERV ARYSMEDAKVTYELGREFFPMEAQLSRLIGQSLWDVSRSSTGNLVEAFLLRKAYKRNELAPNKPDERELARRRGGYA GG YVKEPERGLWDNIVYLD FRSWYPS I IITHNVSPDTLNREGCKEYDVAPEVGHKFCKDFPGFIPSLLGDLLEEASK IERKMKATVDPLEKKLLVYRQWLIKILANSFYGYMGYAKAR WYCKECAESVTAWGREYIEMVIRELEEKFGFKVLYA

EIAKETQARVLEAILKHGDVEEAVRIVKEVTEKLSKYEVPPEKLVIHEQITRDLRDYKATGPHVAVAKRLAARGVKI RPGTVISYIVLKGSGRIGDRAIPADEFDPTKHRYDAEYYIENQVLPAVERILKAFGYRKEDLRYQKTKQVGSGAWLK VKGKKGTEAYVEQKL I S EEDLNSAVDHHHHHH *

Table 8 (cont.)

TABLE 8 Klenow Exo- Polymerase and Mutants

SEQ ID NO: 751

ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGCATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

CGACGATGACGATAAGGATCCGAGCTCGACCATGGTGATTTCTTATGACAACTACGTCACCATCCTTGATGAAGAAA

CACTGAAAGCGTGGATTGCGAACGTGGAAAAAGCGCCGGTATTTGCATTTGCTACCGCAACCGACAGCCTTGATAAC

ATCTCTGCTAACCTGGTCGGGCTTTCTTTTGCTATCGAGCCAGGCGTAGCGGCATATATTCCGGTTGCTCATGATTA

TCTTGATGCGCCCGATCAAATCTCTCGCGAGCGTGCACTCGAGTTGCTAAAACCGCTGCTGGAAGATGAAAAGGCGC

TGAAGGTCGGGCAAAACCTGAAATACGATCGCGGTATTCTGGCGAACTACGGCATTGAACTGCGTGGGATTGCGTTT

GATACCATGCTGGAGTCCTACATTCTCAATAGCGTTGCCGGGCGTCACGATATGGACAGCCTCGCGGAACGTTGGTT

GAAGCACAAAACCATCACTTTTGAAGAGATTGCTGGTAAAGGCAAAAATCAACTGACCTTTAACCAGATTGCCCTCG

AAGAAGCCGGACGTTACGCCGCCGAAGATGCAGATGTCACCTTGCAGTTGCATCTGAAAATGTGGCCGGATCTGCAA

AAACACAAAGGGCCGTTGAACGTCTTCGAGAATATCGAAATGCCGCTGGTGCCGGTGCTTTCACGCATTGAACGTAA

AAGCGCATGAAATTGCAGGTGAGGAATTTAACCTTtCTTCCACCAAGCAGTTACAAACCATTCTCTTTGAAAAACAG GGCATTAAACCGCTGAAGAAAACGCCGGGTGGCGCGCCGTCAACGTCGGAAGAGGTACTGGAAGAACTGGCGCTGGA CTATCCGTTGCCAAAAGTGATTCTGGAGTATCGTGGTCTGGCGAAGCTGAAATCGACCTACACCGACAAGCTGCCGC

ACCGATCCTAACCTGCAAAACATTCCGGTGCGTAACGAAGAAGGTCGTCGTATCCGCCAGGCGTTTATTGCGCCAGA

GTCACCAGCGAGCAACGCCGTAGCGCGAAAGCGATCAACTTTGGTCTGATTTATGGCATGAGTGCTTTCGGTCTGGC GCGGCAATTGAACATTCCACGTAAAGAAGCGCAGAAGTACATGGACCTTTACTTCGAACGCTACCCTGGCGTGCTGG

CTAA

SEQ ID NO: 752

MGGSHHHHHHGMASMTGGQQMGRDLYDDDDKDPSSTMVISYDNYVTILDEETLKAWIANVEKAPVFAFATATDSLDN ISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAF DTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQ KHKGPLNVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQ GIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSS TDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLET VTSEQRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYL PDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQIHQ LMENCTRLDVPLLVEVGSGENWDQAH*

SEQ ID NO: 753

ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGCATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

CGACGATGACGATAAGGATCCGAGCTCGACCATGGTGATTTCTTATGACAACTACGTCACCATCCTTGATGAAGAAA

ATCTCTGCTAACCTGGTCGGGCTTTCTTTTGCTATCGAGCCAGGCGTAGCGGCATATATTCCGGTTGCTCATGATTA

TGAAGGTCGGGCAAAACCTGAAATACGATCGCGGTATTCTGGCGAACTACGGCATTGAACTGCGTGGGATTGCGTTT GATACCATGCTGGAGTCCTACATTCTCAATAGCGTTGCCGGGCGTCACGATATGGACAGCCTCGCGGAACGTTGGTT GAAGCACAAAACCATCACTTTTGAAGAGATTGCTGGTAAAGGCAAAAATCAACTGACCTTTAACCAGATTGCCCTCG

AAACACAAAGGGCCGTTGAACGTCTTCGAGAATATCGAAATGCCGCTGGTGCCGGTGCTTTCACGCATTGAACGTAA CGGTGTGAAGATCGATCCGAAAGTGCTGCACAATCATTCTGAAGAGCTCACCCTTCGTCTGGCTGAGCTGGAAAAGA AAGCGCATGAAATTGCAGGTGAGGAATTTAACCTTTCTTCCACCAAGCAGTTACAAACCATTCTCTTTGAAAAACAG GGCATTAAACCGCTGAAGAAAACGCCGGGTGGCGCGCCGTCAACGTCGGAAGAGGTACTGGAAGAACTGGCGCTGGA CTATCCGTTGCCAAAAGTGATTCTGGAGTATCGTGGTCTGGCGAAGCTGAAATCGACCTACACCGACAAGCTGCCGC TGATGATCAACCCGAAAACCGGGCGTGTGCATACCTCTTATCACCAGGCAGTAACTGCAACGGGACGTTTATCGTCA ACCGATCCTAACCTGCAAAACATTCCGTGTCGTAACGAAGAAGGTCGTCGTATCCGCCAGGCGTTTATTGCGCCAGA Table8(cont.)

GGATTATGTGATTGTCTCAGCGGACTACTCGCAGATTGAACTGCGCATTATGGCGCATCTTTCGCGTGACAAAGGCT TGCTGACCGCATTCGCGGAAGGAAAAGATATCCACCGGGCAACGGCGGCAGAAGTGTTTGGTTTGCCACTGGAAACC GTCACCAGCGAGCAACGCCGTAGCGCGAAAGCGATCAACTTTGGTCTGATTTATGGCATGAGTGCTTTCGGTCTGGC GCGGCAATTGAACATTCCACGTAAAGAAGCGCAGAAGTACATGGACCTTTACTTCGAACGCTACCCTGGCGTGCTGG AGTATATGGAACGCACCCGTGCTCAGGCGAAAGAGCAGGGCTACGTTGAAACGCTGGACGGACGCCGTCTGTATCTG CCGGATATCAAATCCAGCAATGGTGCTCGTCGTGCAGCGGCTGAACGTGCAGCCATTAACGCACCAATGCAGGGAAC CGCCGCCGACATTATCAAACGGGCGATGATTGCCGTTGATGCGTGGTTACAGGCTGAGCAACCGCGTGTACGTATGA TCATGCAGGTACACGATGAACTGGTATTTGAAGTTCATAAAGATGATGTTGATGCCGTCGCGAAGCAGATTCATCAA CTGATGGAAAACTGTACCCGTCTGGATGTGCCGTTGCTGGTGGAAGTGGGGAGTGGCGAAAACTGGGATCAGGCGCA CTAA

SEQ ID NO: 754

MGGSHHHHHHGMASMTGGQQMGRDLYDDDDKDPSSTMVISYDNYVTILDEETLKAWIANVEKAPVFAFATATDSLDN

ISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAF

DTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQ

KHKGPLNVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQ

GIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSS

TDPNLQNIPCRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLET

VTSEQRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYL

PDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQIHQ

LMENCTRLDVPLLVEVGSGENWDQAH*

SEQ ID NO: 755 CGACGATGACGATAAGGATCCGAGCTCGACCATGGTGATTTCTTATGACAACTACGTCACCATCCTTGATGAAGAAA

ATCTCTGCTAACCTGGTCGGGCTTTCTTTTGCTATCGAGCCAGGCGTAGCGGCATATATTCCGGTTGCTCATGATTA TCTTGATGCGCCCGATCAAATCTCTCGCGAGCGTGCACTCGAGTTGCTAAAACCGCTGCTGGAAGATGAAAAGGCGC

3TTT 3GTT GAAGCACAAAACCATCACTTTTGAAGAGATTGCTGGTAAAGGCAAAAATCAACTGACCTTTAACCAGATTGCCCTCG

AAGCGCATGAAATTGCAGGTGAGGAATTTAACCTTTCTTCCACCAAGCAGTTACAAACCATTCTCTTTGAAAAACAG

GGATTATGTGATTGTCTCAGCGGACTACTCGCAGAAGGAACTGCGCATTATGGCGCATCTTTCGCGTGACAAAGGCT GTCACCAGCGAGCAACGCCGTAGCGCGAAAGCGATCAACTTTGGTCTGATTTATGGCATGAGTGCTTTCGGTCTGGC AGTATATGGAACGCACCCGTGCTCAGGCGAAAGAGCAGGGCTACGTTGAAACGCTGGACGGACGCCGTCTGTATCTG CGCCGCCGACATTATCAAACGGGCGATGATTGCCGTTGATGCGTGGTTACAGGCTGAGCAACCGCGTGTACGTATGA

CTGATGGAAAACTGTACCCGTCTGGATGTGCCGTTGCTGGTGGAAGTGGGGAGTGGCGAAAACTGGGATCAGGCGCA CTAA

SEQ ID NO: 756

MGGSHHHHHHGMASMTGGQQMGRDLYDDDDKDPSSTMVISYDNYVTILDEETLKAWIANVEKAPVFAFATATDSLDN ISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAF DTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQ KHKGPLNVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQ GIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSS TDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQKELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLET VTSEQRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYL PDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQIHQ LMENCTRLDVPLLVEVGSGENWDQAH* Table8(cont.)

SEQ ¹IC-NO':' 757"

ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGCATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

CGACGATGACGATAAGGATCCGAGCTCGACCATGGTGATTTCTTATGACAACTACGTCACCATCCTTGATGAAGAAA

CACTGAAAGCGTGGATTGCGAACGTGGAAAAAGCGCCGGTATTTGCATTTGCTACCGCAACCGACAGCCTTGATAAC

ATCTCTGCTAACCTGGTCGGGCTTTCTTTTGCTATCGAGCCAGGCGTAGCGGCATATATTCCGGTTGCTCATGATTA

TCTTGATGCGCCCGATCAAATCTCTCGCGAGCGTGCACTCGAGTTGCTAAAACCGCTGCTGGAAGATGAAAAGGCGC

TGAAGGTCGGGCAAAACCTGAAATACGATCGCGGTATTCTGGCGAACTACGGCATTGAACTGCGTGGGATTGCGTTT

GATACCATGCTGGAGTCCTACATTCTCAATAGCGTTGCCGGGCGTCACGATATGGACAGCCTCGCGGAACGTTGGTT

GAAGCACAAAACCATCACTTTTGAAGAGATTGCTGGTAAAGGCAAAAATCAACTGACCTTTAACCAGATTGCCCTCG

AAGAAGCCGGACGTTACGCCGCCGAAGATGCAGATGTCACCTTGCAGTTGCATCTGAAAATGTGGCCGGATCTGCAA

AAACACAAAGGGCCGTTGAACGTCTTCGAGAATATCGAAATGCCGCTGGTGCCGGTGCTTTCACGCATTGAACGTAA

CGGTGTGAAGATCGATCCGAAAGTGCTGCACAATCATTCTGAAGAGCTCACCCTTCGTCTGGCTGAGCTGGAAAAGA

AAGCGCATGAAATTGCAGGTGAGGAATTTAACCTTTCTTCCACCAAGCAGTTACAAACCATTCTCTTTGAAAAACAG

GGCATTAAACCGCTGAAGAAAACGCCGGGTGGCGCGCCGTCAACGTCGGAAGAGGTACTGGAAGAACTGGCGCTGGA

CTATCCGTTGCCAAAAGTGATTCTGGAGTATCGTGGTCTGGCGAAGCTGAAATCGACCTACACCGACAAGCTGCCGC

TGATGATCAACCCGAAAACCGGGCGTGTGCATACCTCTTATCACCAGGCAGTAACTGCAACGGGACGTTTATCGTCA

ACCGATCCTAACCTGCAAAACATTCCGGTGCGTAACGAAGAAGGTCGTCGTATCCGCCAGGCGTTTATTGCGCCAGA

GGATTATGTGATTGTCTCAGCGGACTACTCGCAGGAAGAACTGCGCATTATGGCGCATCTTTCGCGTGACAAAGGCT

TGCTGACCGCATTCGCGGAAGGAAAAGATATCCACCGGGCAACGGCGGCAGAAGTGTTTGGTTTGCCACTGGAAACC

AGTATATGGAACGCACCCGTGCTCAGGCGAAAGAGCAGGGCTACGTTGAAACGCTGGACGGACGCCGTCTGTATCTG CGCCGCCGACATTATCAAACGGGCGATGATTGCCGTTGATGCGTGGTTACAGGCTGAGCAACCGCGTGTACGTATGA

CTAA

SEQ ID NO: 758

MGGSHHHHHHGMASMTGGQQMGRDLYDDDDKDPSSTMVISYDNYVTILDEETLKAWIANVEKAPVFAFATATDSL₁DN

ISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAF

DTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQ

KHKGPLNVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQ

GIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSS

TDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQEELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLET

VTSEQRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYL

PDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQIHQ

LMENCTRLDVPLLVEVGSGENWDQAH*

SEQ ID NO: 759

CGACGATGACGATAAGGATCCGAGCTCGACCATGGTGATTTCTTATGACAACTACGTCACCATCCTTGATGAAGAAA ATCTCTGCTAACCTGGTCGGGCTTTCTTTTGCTATCGAGCCAGGCGTAGCGGCATATATTCCGGTTGCTCATGATTA TGAAGGTCGGGCAAAACCTGAAATACGATCGCGGTATTCTGGCGAACTACGGCATTGAACTGCGTGGGATTGCGTTT

AAGAAGCCGGACGTTACGCCGCCGAAGATGCAGATGTCACCTTGCAGTTGCATCTGAAAATGTGGCCGGATCTGCAA

CGGTGTGAAGATCGATCCGAAAGTGCTGCACAATCATTCTGAAGAGCTCACCCTTCGTCTGGCTGAGCTGGAAAAGA AAGCGCATGAAATTGCAGGTGAGGAATTTAACCTTTCTTCCACCAAGCAGTTACAAACCATTCTCTTTGAAAAACAG

ACCGATCCTAACCTGCAAAACATTCCGGTGCGTAACGAAGAAGGTCGTCGTATCCGCCAGGCGTTTATTGCGCCAGA TGCTGACCGCATTCGCGGAAGGAAAAGATATCCACCGGGCAACGGCGGCAGAAGTGTTTGGTTTGCCACTGGAAACC

GCGGCAATTGAACATTCCACGTAAAGAAGCGCAGAAGTACATGGACCTTTACTTCGAACGCTACCCTGGCGTGCTGG AGTATATGGAACGCACCCGTGCTCAGGCGAAAGAGCAGGGCTACGTTGAAACGCTGGACGGACGCCGTCTGTATCTG Table8(cont.)

CGCCGCCGACATTATCAAACGGGCGATGATTGCCGTTGATGCGTGGTTACAGGCTGAGCAACCGCGTGTACGTATGA TCATGCAGGTACACGATGAACTGGTATTTGAAGTTCATAAAGATGATGTTGATGCCGTCGCGAAGCAGATTCATCAA CTGATGGAAAACTGTACCCGTCTGGATGTGCCGTTGCTGGTGGAAGTGGGGAGTGGCGAAAACTGGGATCAGGCGCA CTAA

SEQ ID NO: 760

MGGSHHHHHHGMASMTGGQQMGRDLYDDDDKDPSSTMVISYDNYVTILDEETLKAWIANVEKAPVFAFATATDSLDN

ISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAF

DTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQ

KHKGPLNVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQ

GIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSS

TDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLET

VTSEQRISAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYL

PDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQIHQ

LMENCTRLDVPLLVEVGSGENWDQAH*

SEQ ID NO: 761 ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGCATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

GTCACCAGCGAGCAACGCCGTAGCTCGAAAGCGATCAACTTTGGTCTGATTTATGGCATGAGTGCTTTCGGTCTGGC

CCGGATATCAAATCCAGCAATGGTGCTCGTCGTGCAGCGGCTGAACGTGCAGCCATTAACGCACCAATGCAGGGAAC TCATGCAGGTACACGATGAACTGGTATTTGAAGTTCATAAAGATGATGTTGATGCCGTCGCGAAGCAGATTCATCAA CTAA

SEQ ID NO: 762

MGGSHHHHHHGMASMTGGQQMGRDLYDDDDKDPSSTMVISYDNYVTILDEETLKAWIANVEKAPVFAFATATDSLDN

ISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAF

DTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQ

KHKGPLNVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQ

GIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSS

TDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLET

VTSEQRRSSKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYL

PDIKSSNGARRAAAERAAINAPMQGTAAD11KRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQIHQ

LMENCTRLDVPLLVEVGSGENWDQAH*

SEQ ID NO: 763

ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGCATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

CGACGATGACGATAAGGATCCGAGCTCGACCATGGTGATTTCTTATGACAACTACGTCACCATCCTTGATGAAGAAA

CACTGAAAGCGTGGATTGCGAACGTGGAAAAAGCGCCGGTATTTGCATTTGCTACCGCAACCGACAGCCTTGATAAC

ATCTCTGCTAACCTGGTCGGGCTTTCTTTTGCTATCGAGCCAGGCGTAGCGGCATATATTCCGGTTGCTCATGATTA Table8(cont.)

TGAAGGTCGGGCAAAACCTGAAATACGATCGCGGTATTCTGGCGAACTACGGCATTGAACTGCGTGGGATTGCGTTT GATACCATGCTGGAGTCCTACATTCTCAATAGCGTTGCCGGGCGTCACGATATGGACAGCCTCGCGGAACGTTGGTT GAAGCACAAAACCATCACTTTTGAAGAGATTGCTGGTAAAGGCAAAAATCAACTGACCTTTAACCAGATTGCCCTCG AAGAAGCCGGACGTTACGCCGCCGAAGATGCAGATGTCACCTTGCAGTTGCATCTGAAAATGTGGCCGGATCTGCAA AAACACAAAGGGCCGTTGAACGTCTTCGAGAATATCGAAATGCCGCTGGTGCCGGTGCTTTCACGCATTGAACGTAA CGGTGTGAAGATCGATCCGAAAGTGCTGCACAATCATTCTGAAGAGCTCACCCTTCGTCTGGCTGAGCTGGAAAAGA AAGCσCATGAAATTGCAGGTGAGGAATTTAACCTTTCTTCCACCAAGCAGTTACAAACCATTCTCTTTGAAAAACAG GGCATTAAACCGCTGAAGAAAACGCCGGGTGGCGCGCCGTCAACGTCGGAAGAGGTACTGGAAGAACTGGCGCTGGA CTATCCGTTGCCAAAAGTGATTCTGGAGTATCGTGGTCTGGCGAAGCTGAAATCGACCTACACCGACAAGCTGCCGC TGATGATCAACCCGAAAACCGGGCGTGTGCATACCTCTTATCACCAGGCAGTAACTGCAACGGGACGTTTATCGTCA ACCGATCCTAACCTGCAAAACATTCCGGTGCGTAACGAAGAAGGTCGTCGTATCCGCCAGGCGTTTATTGCGCCAGA GGATTATGTGATTGTCTCAGCGGACTACTCGCAGATTGAACTGCGCATTATGGCGCATCTTTCGCGTGACAAAGGCT TGCTGACCGCATTCGCGGAAGGAAAAGATATCCACCGGGCAACGGCGGCAGAAGTGTTTGGTTTGCCACTGGAAACC GTCACCAGCGAGCAACGCCGTAGCGCGAAAGCGATCAACTTTGGTCTGATTTATGGCATGAGTGCTTTCGGTCTGGC GCGGCAATT₁GAACATTCCACGTAAAGAAGCGCAGAAGTACATGGACGGGTACTTCGAACGCTACCCTGGCGTGCTGG AGTATATGGAACGCACCCGTGCTCAGGCGAAAGAGCAGGGCTACGTTGAAACGCTGGACGGACGCCGTCTGTATCTG

CGCCGCCGACATTATCAAACGGGCGATGATTGCCGTTGATGCGTGGTTACAGGCTGAGCAACCGCGTGTACGTATGA

CTGATGGAAAACTGTACCCGTCTGGATGTGCCGTTGCTGGTGGAAGTGGGGAGTGGCGAAAACTGGGATCAGGCGCA CTAA

SEQ ID NO: 764

MGGSHHHHHHGMASMTGGQQMGRDLYDDDDKDPSSTMVISYDNYVTILDEETLKAWIANVEKAPVFAFATATDSLDN

ISANLVGLSFAIEPGVAAYIPVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAF

DTMLESYILNSVAGRHDMDSLAERWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPDLQ

KHKGPLNVFENIEMPLVPVLSRIERNGVKIDPKVLHNHSEELTLRLAELEKKAHEIAGEEFNLSSTKQLQTILFEKQ

GIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSS

TDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLET

VTSEQRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDGYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYL

PDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDELVFEVHKDDVDAVAKQIHQ

LMENCTRLDVPLLVEVGSGENWDQAH*

Table 9 (cont.)

TABLE 9 Taq Polymerase and Mutants

SEQ ID NO: 765

ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGAATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

CGACGATGACGATAAGATGAGAGGGATGCTGCCCCTCTTTGAGCCCAAGGGCCGGGTCCTCCTGGTGGACGGCCACC

ACCTGGCCTACCGCACCTTCCACGCCCTGAAGGGCCTCACCACCAGCCGGGGGGAGCCGGTGCAGGCGGTCTACGGC

TTCGCCAAGAGCCTCCTCAAGGCCCTCAAGGAGGACGGGGACGCGGTGATCGTGGTCTTTGACGCCAAGGCCCCCTC

CTTCCGCCACGAGGCCTACGGGGGGTACAAGGCGGGCCGGGCCCCCACGCCGGAGGACTTTCCCCGGCAACTCGCCC

TCATCAAGGAGCTGGTGGACCTCCTGGGGCTGGCGCGCCTCGAGGTCCCGGGCTACGAGGCGGACGACGTCCTGGCC

AGCCTGGCCAAGAAGGCGGAAAAGGAGGGCTACGAGGTCCGCATCCTCACCGCCGACAAAGACCTTTACCAGCTCCT

GAGAAGACGGCGAGGAAGCTTCTGGAGGAGTGGGGGAGCCTGGAAGCCCTCCTCAAGAACCTGGACCGGCTGAAGCC CGCCATCCGGGAGAAGATCCTGGCCCACATGGACGATCTGAAGCTCTCCTGGGACCTGGCCAAGGTGCGCACCGACC TGCCCCTGGAGGTGGACTTCGCCAAAAGGCGGGAGCCCGACCGGGAGAGGCTTAGGGCCTTTCTGGAGAGGCTTGAG TTTGGCAGCCTCCTCCACGAGTTCGGCCTTCTGGAAAGCCCCAAGGCCCTGGAGGAGGCCCCCTGGCCCCCGCCGGA AGGGGCCTTCGTGGGCTTTGTGCTTTCCCGCAAGGAGCCCATGTGGGCCGATCTTCTGGCCCTGGCCGCCGCCAGGG GGGGCCGGGTCCACCGGGCCCCCGAGCCTTATAAAGCCCTCAGGGACCTGAAGGAGGCGCGGGGGCTTCTCGCCAAA

GGACCCTTCCAACACCACCCCCGAGGGGGTGGCCCGGCGCTACGGCGGGGAGTGGACGGAGGAGGCGGGGGAGCGGG GAGGTGGAGAGGCCCCTTTCCGCTGTCCTGGCCCACATGGAGGCCACGGGGGTGCGCCTGGACGTGGCCTATCTCAG

GTACCGGGAGCTCACCAAGCTGAAGAGCACCTACATTGACCCCTTGCCGGACCTCATCCACCCCAGGACGGGCCGCC TCCACACCCGCTTCAACCAGACGGCCACGGCCACGGGCAGGCTAAGTAGCTCCGATCCCAACCTCCAGAACATCCCC GTACGCACCCCGCTTGGGCAGAGGATCCGCCGGGCCTTCATCGCCGAGGAGGGGTGGCTATTGGTGGCCCTGGACTA TAGCCAGATAGAGCTCAGGGTGCTGGCCCACCTCTCCGGCGACGAGAACCTGATCCGGGTCTTCCAGGAGGGGCGGG

AAGACCATCAACTTCGGGGTCCTCTACGGCATGTCGGCCCACCGCCTCTCCCAGGAGCTAGCCATCCCTTACGAGGA GGCCCAGGCCTTCATTGAGCGCTACTTTCAGAGCTTCCCCAAGGTGCGGGCCTGGATTGAGAAGACCCTGGAGGAGG GCAGGAGGCGGGGGTACGTGGAGACCCTCTTCGGCCGCCGCCGCTACGTGCCAGACCTAGAGGCCCGGGTGAAGAGC GTGCGGGAGGCGGCCGAGCGCATGGCCTTCAACATGCCCGTCCAGGGCACCGCCGCCGACCTCATGAAGCTGGCTAT GGTGAAGCTCTTCCCCAGGCTGGAGGAAATGGGGGCCAGGATGCTCCTTCAGGTCCACGACGAGCTGGTCCTCGAGG CCCCAAAAGAGAGGGCGGAGGCCGTGGCCCGGCTGGCCAAGGAGGTCATGGAGGGGGTGTATCCCCTGGCCGTGCCC CTGGAGGTGGAGGTGGGGATAGGGGAGGACTGGCTCTCCGCCAAGGAGTGA

SEQ ID NO: 766

MGGSHHHHHHGMARMTGGQQMGRDLYDDDDKMRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYG

FAKSLLKALKEDGDAVIWFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLA

SLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIG

EKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLKLSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLE

FGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAK

DLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYR

EVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEK

TGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIP

VRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAA

KTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS

VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP

LEVEVGIGEDWLSAKE*

SEQ ID NO: 767

ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGAATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

CGACGATGACGATAAGATGAGAGGGATGCTGCCCCTCTTTGAGCCCAAGGGCCGGGTCCTCCTGGTGGACGGCCACC

ACCTGGCCTACCGCACCTTCCACGCCCTGAAGGGCCTCACCACCAGCCGGGGGGAGCCGGTGCAGGCGGTCTACGGC

TTCGCCAAGAGCCTCCTCAAGGCCCTCAAGGAGGACGGGGACGCGGTGATCGTGGTCTTTGACGCCAAGGCCCCCTC

CTTCCGCCACGAGGCCTACGGGGGGTACAAGGCGGGCCGGGCCCCCACGCCGGAGGACTTTCCCCGGCAACTCGCCC

TCATCAAGGAGCTGGTGGACCTCCTGGGGCTGGCGCGCCTCGAGGTCCCGGGCTACGAGGCGGACGACGTCCTGGCC Table 9 (cont.)

AGCC*GβcdAAGMG<3<Mσ;ilA_^(M$<^

TTCCGACCGCATCCACGTCCTCCACCCCGAGGGGTACCTCATCACCCCGGCCTGGCTTTGGGAAAAGTACGGCCTGA GGCCCGACCAGTGGGCCGACTACCGGGCCCTGACCGGGGACGAGTCCGACAACCTTCCCGGGGTCAAGGGCATCGGG GAGAAGACGGCGAGGAAGCTTCTGGAGGAGTGGGGGAGCCTGGAAGCCCTCCTCAAGAACCTGGACCGGCTGAAGCC CGCCATCCGGGAGAAGATCCTGGCCCACATGGACGATCTGAAGCTCTCCTGGGACCTGGCCAAGGTGCGCACCGACC TGCCCCTGGAGGTGGACTTCGCCAAAAGGCGGGAGCCCGACCGGGAGAGGCTTAGGGCCTTTCTGGAGAGGCTTGAG TTTGGCAGCCTCCTCCACGAGTTCGGCCTTCTGGAAAGCCCCAAGGCCCTGGAGGAGGCCCCCTGGCCCCCGCCGGA AGGGGCCTTCGTGGGCTTTGTGCTTTCCCGCAAGGAGCCCATGTGGGCCGATCTTCTGGCCCTGGCCGCCGCCAGGG GGGGCCGGGTCCACCGGGCCCCCGAGCCTTATAAAGCCCTCAGGGACCTGAAGGAGGCGCGGGGGCTTCTCGCCAAA GACCTGAGCGTTCTGGCCCTGAGGGAAGGCCTTGGCCTCCCGCCCGGCGACGACCCCATGCTCCTCGCCTACCTCCT GGACCCTTCCAACACCACCCCCGAGGGGGTGGCCCGGCGCTACGGCGGGGAGTGGACGGAGGAGGCGGGGGAGCGGG CCGCCCTTTCCGAGAGGCTCTTCGCCAACCTGTGGGGGAGGCTTGAGGGGGAGGAGAGGCTCCTTTGGCTTTACCGG GAGGTGGAGAGGCCCCTTTCCGCTGTCCTGGCCCACATGGAGGCCACGGGGGTGCGCCTGGACGTGGCCTATCTCAG GGCCTTGTCCCTGGAGGTGGCCGAGGAGATCGCCCGCCTCGAGGCCGAGGTCTTCCGCCTGGCCGGCCACCCCTTCA ACCTCAACTCCCGGGACCAGCTGGAAAGGGTCCTCTTTGACGAGCTAGGGCTTCCCGCCATCGGCAAGACGGAGAAG ACCGGCAAGCGCTCCACCAGCGCCGCCGTCCTGGAGGCCCTCCGCGAGGCCCACCCCATCGTGGAGAAGATCCTGCA GTACCGGGAGCTCACCAAGCTGAAGAGCACCTACATTGACCCCTTGCCGGACCTCATCCACCCCAGGACGGGCCGCC

GTACGCACCCCGCTTGGGCAGAGGATCCGCCGGGCCTTCATCGCCGAGGAGGGGTGGCTATTGGTGGCCCTGGACTA TAGCCAGATAGAGCTCAGGGTGCTGGCCCACCTCTCCGGCGACGAGAACCTGATCCGGGTCTTCCAGGAGGGGCGGG ACATCCACACGGAGACCGCCAGCTGGATGTTCGGGGTCCCGCGGGAGGCCGTGGACCCCCTGATGCGCTACGCGGCC

GGCCCAGGCCTTCATTGAGCGCTACTTTCAGAGCTTCCCCAAGGTGCGGGCCTGGATTGAGAAGACCCTGGAGGAGG GCAGGAGGCGGGGGTACGTGGAGACCCTCTTCGGCCGCCGCCGCTACGTGCCAGACCTAGAGGCCCGGGTGAAGAGC GTGCGGGAGGCGGCCGAGCGCATGGCCTTCAACATGCCCGTCCAGGGCACCGCCGCCGACCTCATGAAGCTGGCTAT

CTGGAGGTGGAGGTGGGGATAGGGGAGGACTGGCTCTCCGCCAAGGAGTGA

SEQ ID NO : 768

MGGSHHHHHHGMARMTGGQQMGRDLYDDDDKMRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYG FAKSLLKALKEDGDAVIWFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLA SLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIG

EVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEK TGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIP VRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRYAA KTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP LEVEVGIGEDWLSAKE*

SEQ ID NO: 769

ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGAATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

CGACGATGACGATAAGATGAGAGGGATGCTGCCCCTCTTTGAGCCCAAGGGCCGGGTCCTCCTGGTGGACGGCCACC

ACCTGGCCTACCGCACCTTCCACGCCCTGAAGGGCCTCACCACCAGCCGGGGGGAGCCGGTGCAGGCGGTCTACGGC

TTCGCCAAGAGCCTCCTCAAGGCCCTCAAGGAGGACGGGGACGCGGTGATCGTGGTCTTTGACGCCAAGGCCCCCTC

CTTCCGCCACGAGGCCTACGGGGGGTACAAGGCGGGCCGGGCCCCCACGCCGGAGGACTTTCCCCGGCAACTCGCCC

TCATCAAGGAGCTGGTGGACCTCCTGGGGCTGGCGCGCCTCGAGGTCCCGGGCTACGAGGCGGACGACGTCCTGGCC

TTCCGACCGCATCCACGTCCTCCACCCCGAGGGGTACCTCATCACCCCGGCCTGGCTTTGGGAAAAGTACGGCCTGA GGCCCGACCAGTGGGCCGACTACCGGGCCCTGACCGGGGACGAGTCCGACAACCTTCCCGGGGTCAAGGGCATCGGG GAGAAGACGGCGAGGAAGCTTCTGGAGGAGTGGGGGAGCCTGGAAGCCCTCCTCAAGAACCTGGACCGGCTGAAGCC CGCCATCCGGGAGAAGATCCTGGCCCACATGGACGATCTGAAGCTCTCCTGGGACCTGGCCAAGGTGCGCACCGACC TGCCCCTGGAGGTGGACTTCGCCAAAAGGCGGGAGCCCGACCGGGAGAGGCTTAGGGCCTTTCTGGAGAGGCTTGAG

AGGGGCCTTCGTGGGCTTTGTGCTTTCCCGCAAGGAGCCCATGTGGGCCGATCTTCTGGCCCTGGCCGCCGCCAGGG

GACCTGAGCGTTCTGGCCCTGAGGGAAGGCCTTGGCCTCCCGCCCGGCGACGACCCCATGCTCCTCGCCTACCTCCT GGACCCTTCCAACACCACCCCCGAGGGGGTGGCCCGGCGCTACGGCGGGGAGTGGACGGAGGAGGCGGGGGAGCGGG Table9(cont.)

CCGdfcdTtTCCGAfeXOStT^fTCiSCaMdciTdTGGGGGAGGCTTGAGGGGGAGGAGAGGCTCCTTTGGCTTTACCGG GAGGTGGAGAGGCCCCTTTCCGCTGTCCTGGCCCACATGGAGGCCACGGGGGTGCGCCTGGACGTGGCCTATCTCAG GGCCTTGTCCCTGGAGGTGGCCGAGGAGATCGCCCGCCTCGAGGCCGAGGTCTTCCGCCTGGCCGGCCACCCCTTCA ACCTCAACTCCCGGGACCAGCTGGAAAGGGTCCTCTTTGACGAGCTAGGGCTTCCCGCCATCGGCAAGACGGAGAAG ACCGGCAAGCGCTCCACCAGCGCCGCCGTCCTGGAGGCCCTCCGCGAGGCCCACCCCATCGTGGAGAAGATCCTGCA GTACCGGGAGCTCACCAAGCTGAAGAGCACCTACATTGACCCCTTGCCGGACCTCATCCACCCCAGGACGGGCCGCC TCCACACCCGCTTCAACCAGACGGCCACGGCCACGGGCAGGCTAAGTAGCTCCGATCCCAACCTCCAGAACATCCCC GTACGCACCCCGCTTGGGCAGAGGATCCGCCGGGCCTTCATCGCCGAGGAGGGGTGGCTATTGGTGGCCCTGGACTA TAGCCAGATAGAGCTCAGGGTGCTGGCCCACCTCTCCGGCGACGAGAACCTGATCCGGGTCTTCCAGGAGGGGCGGG ACATCCACACGGAGACCGCCAGCTGGATGTTCGGGGTCCCGCGGGAGGCCGTGGACCCCCTGATGCGCCGGGCGGGT AAGACCATCAACTTCGGGGTCCTCTACGGCATGTCGGCCCACCGCCTCTCCCAGGAGCTAGCCATCCCTTACGAGGA GGCCCAGGCCTTCATTGAGCGCTACTTTCAGAGCTTCCCCAAGGTGCGGGCCTGGATTGAGAAGACCCTGGAGGAGG GCAGGAGGCGGGGGTACGTGGAGACCCTCTTCGGCCGCCGCCGCTACGTGCCAGACCTAGAGGCCCGGGTGAAGAGC GTGCGGGAGGCGGCCGAGCGCATGGCCTTCAACATGCCCGTCCAGGGCACCGCCGCCGACCTCATGAAGCTGGCTAT GGTGAAGCTCTTCCCCAGGCTGGAGGAAATGGGGGCCAGGATGCTCCTTCAGGTCCACGACGAGCTGGTCCTCGAGG 'CCCCAAAAGAGAGGGCGGAGGCCGTGGCCCGGCTGGCCAAGGAGGTCATGGAGGGGGTGTATCCCCTGGCCGTGCCC CTGGAGGTGGAGGTGGGGATAGGGGAGGACTGGCTCTCCGCCAAGGAGTGA

SEQ ID NO: 770

MGGSHHHHHHGMARMTGGQQMGRDLYDDDDKMRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYG

FAKSLLKALKEDGDAVIWFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLA

SLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIG

EKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLKLSWDLAKVRTDIiPLEVDFAKRREPDRERLRAFLERLE

DLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYR EVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEK TGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIP VRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAG KTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP LEVEVGIGEDWLSAKE*

SEQ ID NO: 771 CGACGATGACGATAAGATGAGAGGGATGCTGCCCCTCTTTGAGCCCAAGGGCCGGGTCCTCCTGGTGGACGGCCACC

TTCGCCAAGAGCCTCCTCAAGGCCCTCAAGGAGGACGGGGACGCGGTGATCGTGGTCTTTGACGCCAAGGCCCCCTC CTTCCGCCACGAGGCCTACGGGGGGTACAAGGCGGGCCGGGCCCCCACGCCGGAGGACTTTCCCCGGCAACTCGCCC

AGCCTGGCCAAGAAGGCGGAAAAGGAGGGCTACGAGGTCCGCATCCTCACCGCCGACAAAGACCTTTACCAGCTCCT

GAGAAGACGGCGAGGAAGCTTCTGGAGGAGTGGGGGAGCCTGGAAGCCCTCCTCAAGAACCTGGACCGGCTGAAGCC TGCCCCTGGAGGTGGACTTCGCCAAAAGGCGGGAGCCCGACCGGGAGAGGCTTAGGGCCTTTCTGGAGAGGCTTGAG

AGGGGCCTTCGTGGGCTTTGTGCTTTCCCGCAAGGAGCCCATGTGGGCCGATCTTCTGGCCCTGGCCGCCGCCAGGG GGGGCCGGGTCCACCGGGCCCCCGAGCCTTATAAAGCCCTCAGGGACCTGAAGGAGGCGCGGGGGCTTCTCGCCAAA GACCTGAGCGTTCTGGCCCTGAGGGAAGGCCTTGGCCTCCCGCCCGGCGACGACCCCATGCTCCTCGCCTACCTCCT GGACCCTTCCAACACCACCCCCGAGGGGGTGGCCCGGCGCTACGGCGGGGAGTGGACGGAGGAGGCGGGGGAGCGGG

GAGGTGGAGAGGCCCCTTTCCGCTGTCCTGGCCCACATGGAGGCCACGGGGGTGCGCCTGGACGTGGCCTATCTCAG

ACCTCAACTCCCGGGACCAGCTGGAAAGGGTCCTCTTTGACGAGCTAGGGCTTCCCGCCATCGGCAAGACGGAGAAG ACCGGCAAGCGCTCCACCAGCGCCGCCGTCCTGGAGGCCCTCCGCGAGGCCCACCCCATCGTGGAGAAGATCCTGCA GTACCGGGAGCTCACCAAGCTGAAGAGCACCTACATTGACCCCTTGCCGGACCTCATCCACCCCAGGACGGGCCGCC TCCACACCCGCTTCAACCAGACGGCCACGGCCACGGGCAGGCTAAGTAGCTCCGATCCCAACCTCCAGAACATCCCC GTACGCACCCCGCTTGGGCAGAGGATCCGCCGGGCCTTCATCGCCGAGGAGGGGTGGCTATTGGTGGCCCTGGACTA TAGCCAGATAGAGCTCAGGGTGCTGGCCCACCTCTCCGGCGACGAGAACCTGATCCGGGTCTTCCAGGAGGGGCGGG ACATCCACACGGAGACCGCCAGCTGGATGTTCGGGGTCCCGCGGGAGGCCGTGGACCCCCTGATGCGCCGGGCGGCC AAGACCATCAACTTCGGGGTCCTCTACGGCATGTCGGCCCACCGCCTCTCCCAGGAGCTAGCCATCCCTTACGAGGA Table9(cont.)

GGCCCAGGCCTTCATTGAGTCGTACTTTCAGAGCTTCCCCAAGGTGCGGGCCTGGATTGAGAAGACCCTGGAGGAGG GCAGGAGGCGGGGGTACGTGGAGACCCTCTTCGGCCGCCGCCGCTACGTGCCAGACCTAGAGGCCCGGGTGAAGAGC GTGCGGGAGGCGGCCGAGCGCATGGCCTTCAACATGCCCGTCCAGGGCACCGCCGCCGACCTCATGAAGCTGGCTAT GGTGAAGCTCTTCCCCAGGCTGGAGGAAATGGGGGCCAGGATGCTCCTTCAGGTCCACGACGAGCTGGTCCTCGAGG CCCCAAAAGAGAGGGCGGAGGCCGTGGCCCGGCTGGCCAAGGAGGTCATGGAGGGGGTGTATCCCCTGGCCGTGCCC CTGGAGGTGGAGGTGGGGATAGGGGAGGACTGGCTCTCCGCCAAGGAGTGA

SEQ ID NO: 772

MGGSHHHHHHGMARMTGGQQMGRDLYDDDDKMRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYG FAKSLLKALKEDGDAVIWFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLA SLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIG EKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLKLSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLE FGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAK

EVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEK TGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIP VRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAA KTINFGVLYGMSAHRLSQELAIPYEEAQAFIESYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP LEVEVGIGEDWLSAKE*

SEQ ID NO: 773

ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGAATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

CGACGATGACGATAAGATGAGAGGGATGCTGCCCCTCTTTGAGCCCAAGGGCCGGGTCCTCCTGGTGGACGGCCACC

ACCTGGCCTACCGCACCTTCCACGCCCTGAAGGGCCTCACCACCAGCCGGGGGGAGCCGGTGCAGGCGGTCTACGGC

TTCGCCAAGAGCCTCCTCAAGGCCCTCAAGGAGGACGGGGACGCGGTGATCGTGGTCTTTGACGCCAAGGCCCCCTC

TCATCAAGGAGCTGGTGGACCTCCTGGGGCTGGCGCGCCTCGAGGTCCCGGGCTACGAGGCGGACGACGTCCTGGCC

TTCCGACCGCATCCACGTCCTCCACCCCGAGGGGTACCTCATCACCCCGGCCTGGCTTTGGGAAAAGTACGGCCTGA GGCCCGACCAGTGGGCCGACTACCGGGCCCTGACCGGGGACGAGTCCGACAACCTTCCCGGGGTCAAGGGCATCGGG GAGAAGACGGCGAGGAAGCTTCTGGAGGAGTGGGGGAGCCTGGAAGCCCTCCTCAAGAACCTGGACCGGCTGAAGCC

TTTGGCAGCCTCCTCCACGAGTTCGGCCTTCTGGAAAGCCCCAAGGCCCTGGAGGAGGCCCCCTGGCCCCCGCCGGA

GACCTGAGCGTTCTGGCCCTGAGGGAAGGCCTTGGCCTCCCGCCCGGCGACGACCCCATGCTCCTCGCCTACCTCCT GGACCCTTCCAACACCACCCCCGAGGGGGTGGCCCGGCGCTACGGCGGGGAGTGGACGGAGGAGGCGGGGGAGCGGG CCGCCCTTTCCGAGAGGCTCTTCGCCAACCTGTGGGGGAGGCTTGAGGGGGAGGAGAGGCTCCTTTGGCTTTACCGG

GGCCTTGTCCCTGGAGGTGGCCGAGGAGATCGCCCGCCTCGAGGCCGAGGTCTTCCGCCTGGCCGGCCACCCCTTCA

ACCGGCAAGCGCTCCACCAGCGCCGCCGTCCTGGAGGCCCTCCGCGAGGCCCACCCCATCGTGGAGAAGATCCTGCA GTACCGGGAGCTCACCAAGCTGAAGAGCACCTACATTGACCCCTTGCCGGACCTCATCCACCCCAGGACGGACCGCC TCCACACCCGCTTCAACCAGACGGCCACGGCCACGGGCAGGCTAAGTAGCTCCGATCCCAACCTCCAGAACATCCCC GTACGCACCCCGCTTGGGCAGAGGATCCGCCGGGCCTTCATCGCCGAGGAGGGGTGGCTATTGGTGGCCCTGGACTA TAGCCAGCACGAGCTCAGGGTGCTGGCCCACCTCTCCGGCGACGAGAACCTGATCCGGGTCTTCCAGGAGGGGCGGG ACATCCACACGGAGACCGCCAGCTGGATGTTCGGGGTCCCGCGGGAGGCCGTGGACCCCCTGATGCGCCGGGCGGCC AAGACCATCAACTTCGGGGTCCTCTACGGCATGTCGGCCCACCGCCTCTCCCAGGAGCTAGCCATCCCTTACGAGGA GGCCCAGGCCTTCATTGAGCGCTACTTTCAGAGCTTCCCCAAGGTGCGGGCCTGGATTGAGAAGACCCTGGAGGAGG GCAGGAGGCGGGGGTACGTGGAGACCCTCTTCGGCCGCCGCCGCTACGTGCCAGACCTAGAGGCCCGGGTGAAGAGC GTGCGGGAGGCGGCCGAGCGCATGGCCTTCAACATGCCCGTCCAGGGCACCGCCGCCGACCTCATGAAGCTGGCTAT GGTGAAGCTCTTCCCCAGGCTGGAGGAAATGGGGGCCAGGATGCTCCTTCAGGTCCACGACGAGCTGGTCCTCGAGG CCCCAAAAGAGAGGGCGGAGGCCGTGGCCCGGCTGGCCAAGGAGGTCATGGAGGGGGTGTATCCCCTGGCCGTGCCC CTGGAGGTGGAGGTGGGGATAGGGGAGGACTGGCTCTCCGCCAAGGAGTGA

SEQ ID NO : 774

MGGSHHHHHHGMARMTGGQQMGRDLYDDDDKMRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYG FAKSLLKALKEDGDAVIWFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLA SLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIG Table9(cont.)

EKTAllKLLEEWSSLEALLKMDRLKPAfgEW

FGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAK

DLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYR

EVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEK

TGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTDRLHTRFNQTATATGRLSSSDPNLQNIP

VRTPLGQRIRRAFIAEEGWLLVALDYSQHELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAA

KTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS

VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP

LEVEVGIGEDWLSAKE*

SEQ ID NO: 775

ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGAATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

CGACGATGACGATAAGATGAGAGGGATGCTGCCCCTCTTTGAGCCCAAGGGCCGGGTCCTCCTGGTGGACGGCCACC

ACCTGGCCTACCGCACCTTCCACGCCCTGAAGGGCCTCACCACCAGCCGGGGGGAGCCGGTGCAGGCGGTCTACGGC

TTCGCCAAGAGCCTCCTCAAGGCCCTCAAGGAGGACGGGGACGCGGTGATCGTGGTCTTTGACGCCAAGGCCCCCTC

CTTCCGCCACGAGGCCTACGGGGGGTACAAGGCGGGCCGGGCCCCCACGCCGGAGGACTTTCCCCGGCAACTCGCCC

TCATCAAGGAGCTGGTGGACCTCCTGGGGCTGGCGCGCCTCGAGGTCCCGGGCTACGAGGCGGACGACGTCCTGGCC

AGCCTGGCCAAGAAGGCGGAAAAGGAGGGCTACGAGGTCCGCATCCTCACCGCCGACAAAGACCTTTACCAGCTCCT

TTCCGACCGCATCCACGTCCTCCACCCCGAGGGGTACCTCATCACCCCGGCCTGGCTTTGGGAAAAGTACGGCCTGA

GGCCCGACCAGTGGGCCGACTACCGGGCCCTGACCGGGGACGAGTCCGACAACCTTCCCGGGGTCAAGGGCATCGGG

GAGAAGACGGCGAGGAAGCTTCTGGAGGAGTGGGGGAGCCTGGAAGCCCTCCTCAAGAACCTGGACCGGCTGAAGCC

CGCCATCCGGGAGAAGATCCTGGCCCACATGGACGATCTGAAGCTCTCCTGGGACCTGGCCAAGGTGCGCACCGACC

TGCCCCTGGAGGTGGACTTCGCCAAAAGGCGGGAGCCCGACCGGGAGAGGCTTAGGGCCTTTCTGGAGAGGCTTGAG

GGGGCCGGGTCCACCGGGCCCCCGAGCCTTATAAAGCCCTCAGGGACCTGAAGGAGGCGCGGGGGCTTCTCGCCAAA GACCTGAGCGTTCTGGCCCTGAGGGAAGGCCTTGGCCTCCCGCCCGGCGACGACCCCATGCTCCTCGCCTACCTCCT

CCGCCCTTTCCGAGAGGCTCTTCGCCAACCTGTGGGGGAGGCTTGAGGGGGAGGAGAGGCTCCTTTGGCTTTACCGG GAGGTGGAGAGGCCCCTTTCCGCTGTCCTGGCCCACATGGAGGCCACGGGGGTGCGCCTGGACGTGGCCTATCTCAG GGCCTTGTCCCTGGAGGTGGCCGAGGAGATCGCCCGCCTCGAGGCCGAGGTCTTCCGCCTGGCCGGCCACCCCTTCA ACCTCAACTCCCGGGACCAGCTGGAAAGGGTCCTCTTTGACGAGCTAGGGCTTCCCGCCATCGGCAAGACGGAGAAG

TAGCCAGTTCGAGCTCAGGGTGCTGGCCCACCTCTCCGGCGACGAGAACCTGATCCGGGTCTTCCAGGAGGGGCGGG AAGACCATCAACTTCGGGGTCCTCTACGGCATGTCGGCCCACCGCCTCTCCCAGGAGCTAGCCATCCCTTACGAGGA

GCAGGAGGCGGGGGTACGTGGAGACCCTCTTCGGCCGCCGCCGCTACGTGCCAGACCTAGAGGCCCGGGTGAAGAGC GTGCGGGAGGCGGCCGAGCGCATGGCCTTCAACATGCCCGTCCAGGGCACCGCCGCCGACCTCATGAAGCTGGCTAT GGTGAAGCTCTTCCCCAGGCTGGAGGAAATGGGGGCCAGGATGCTCCTTCAGGTCCACGACGAGCTGGTCCTCGAGG CCCCAAAAGAGAGGGCGGAGGCCGTGGCCCGGCTGGCCAAGGAGGTCATGGAGGGGGTGTATCCCCTGGCCGTGCCC CTGGAGGTGGAGGTGGGGATAGGGGAGGACTGGCTCTCCGCCAAGGAGTGA

SEQ ID NO: 776

MGGSHHHHHHGMARMTGGQQMGRDLYDDDDKMRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYG

FAKSLLKALKEDGDAVIWFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLA

SLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIG

EKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLKLSWDI-AKVRTDLPLEVDFAKRREPDRERLRAFLERLE

DLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYR EVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEK TGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIP VRTPLGQRIRRAFIAEEGWLLVALDYSQFELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAA KTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP LEVEVGIGEDWLSAKE*

SEQ ID NO: 777 Table9(cont.)

ATG(^di∞fTCT'tΑτt;ΑtCAfαV^l!-'CAf(ΪAf(3<§TATGGCTAGAATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA CGACGATGACGATAAGATGAGAGGGATGCTGCCCCTCTTTGAGCCCAAGGGCCGGGTCCTCCTGGTGGACGGCCACC ACCTGGCCTACCGCACCTTCCACGCCCTGAAGGGCCTCACCACCAGCCGGGGGGAGCCGGTGCAGGCGGTCTACGGC TTCGCCAAGAGCCTCCTCAAGGCCCTCAAGGAGGACGGGGACGCGGTGATCGTGGTCTTTGACσCCAAGGCCCCCTC CTTCCGCCACGAGGCCTACGGGGGGTACAAGGCGGGCCGGGCCCCCACGCCGGAGGACTTTCCCCGGCAACTCGCCC TCATCAAGGAGCTGGTGGACCTCCTGGGGCTGGCGCGCCTCGAGGTCCCGGGCTACGAGGCGGACGACGTCCTGGCC AGCCTGGCCAAGAAGGCGGAAAAGGAGGGCTACGAGGTCCGCATCCTCACCGCCGACAAAGACCTTTACCAGCTCCT TTCCGACCGCATCCACGTCCTCCACCCCGAGGGGTACCTCATCACCCCGGCCTGGCTTTGGGAAAAGTACGGCCTGA GGCCCGACCAGTGGGCCGACTACCGGGCCCTGACCGGGGACGAGTCCGACAACCTTCCCGGGGTCAAGGGCATCGGG GAGAAGACGGCGAGGAAGCTTCTGGAGGAGTGGGGGAGCCTGGAAGCCCTCCTCAAGAACCTGGACCGGCTGAAGCC CGCCATCCGGGAGAAGATCCTGGCCCACATGGACGATCTGAAGCTCTCCTGGGACCTGGCCAAGGTGCGCACCGACC TGCCCCTGGAGGTGGACTTCGCCAAAAGGCGGGAGCCCGACCGGGAGAGGCTTAGGGCCTTTCTGGAGAGGCTTGAG TTTGGCAGCCTCCTCCACGAGTTCGGCCTTCTGGAAAGCCCCAAGGCCCTGGAGGAGGCCCCCTGGCCCCCGCCGGA

GACCTGAGCGTTCTGGCCCTGAGGGAAGGCCTTGGCCTCCCGCCCGGCGACGACCCCATGCTCCTCGCCTACCTCCT

CCGCCCTTTCCGAGAGGCTCTTCGCCAACCTGTGGGGGAGGCTTGAGGGGGAGGAGAGGCTCCTTTGGCTTTACCGG GAGGTGGAGAGGCCCCTTTCCGCTGTCCTGGCCCACATGGAGGCCACGGGGGTGCGCCTGGACGTGGCCTATCTCAG

ACCTCAACTCCCGGGACCAGCTGGAAAGGGTCCTCTTTGACGAGCTAGGGCTTCCCGCCATCGGCAAGACGGAGAAG ACCGGCAAGCGCTCCACCAGCGCCGCCGTCCTGGAGGCCCTCCGCGAGGCCCACCCCATCGTGGAGAAGATCCTGCA GTACCGGGAGCTCACCAAGCTGAAGAGCACCTACATTGACCCCTTGCCGGACCTCATCCACCCCAGGACGGGCCGCC

TAGCCAGCACGAGCTCAGGGTGCTGGCCCACCTCTCCGGCGACGAGAACCTGATCCGGGTCTTCCAGGAGGGGCGGG AAGACCATCAACTTCGGGGTCCTCTACGGCATGTCGGCCCACCGCCTCTCCCAGGAGCTAGCCATCCCTTACGAGGA

GCAGGAGGCGGGGGTACGTGGAGACCCTCTTCGGCCGCCGCCGCTACGTGCCAGACCTAGAGGCCCGGGTGAAGAGC GTGCGGGAGGCGGCCGAGCGCATGGCCTTCAACATGCCCGTCCAGGGCACCGCCGCCGACCTCATGAAGCTGGCTAT

CCCCAAAAGAGAGGGCGGAGGCCGTGGCCCGGCTGGCCAAGGAGGTCATGGAGGGGGTGTATCCCCTGGCCGTGCCC CTGGAGGTGGAGGTGGGGATAGGGGAGGACTGGCTCTCCGCCAAGGAGTGA

SEQ ID NO: 778

MGGSHHHHHHGMARMTGGQQMGRDLYDDDDKMRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYG FAKSLLKALKEDGDAVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLA SLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIG

DLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYR EVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEK

TGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIP VRTPLGQRIRRAFIAEEGWLLVALDYSQHELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAA KTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP LEVEVGIGEDWLSAKE*

SEQ ID NO: 779 ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGAATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

TTCGCCAAGAGCCTCCTCAAGGCCCTCAAGGAGGACGGGGACGCGGTGATCGTGGTCTTTGACGCCAAGGCCCCCTC

TCATCAAGGAGCTGGTGGACCTCCTGGGGCTGGCGCGCCTCGAGGTCCCGGGCTACGAGGCGGACGACGTCCTGGCC AGCCTGGCCAAGAAGGCGGAAAAGGAGGGCTACGAGGTCCGCATCCTCACCGCCGACAAAGACCTTTACCAGCTCCT TTCCGACCGCATCCACGTCCTCCACCCCGAGGGGTACCTCATCACCCCGGCCTGGCTTTGGGAAAAGTACGGCCTGA GGCCCGACCAGTGGGCCGACTACCGGGCCCTGACCGGGGACGAGTCCGACAACCTTCCCGGGGTCAAGGGCATCGGG GAGAAGACGGCGAGGAAGCTTCTGGAGGAGTGGGGGAGCCTGGAAGCCCTCCTCAAGAACCTGGACCGGCTGAAGCC CGCCATCCGGGAGAAGATCCTGGCCCACATGGACGATCTGAAGCTCTCCTGGGACCTGGCCAAGGTGCGCACCGACC Table9(cont.)

TTTGGCAGCCTCCTCCACGAGTTCGGCCTTCTGGAAAGCCCCAAGGCCCTGGAGGAGGCCCCCTGGCCCCCGCCGGA

AGGGGCCTTCGTGGGCTTTGTGCTTTCCCGCAAGGAGCCCATGTGGGCCGATCTTCTGGCCCTGGCCGCCGCCAGGG

GGGGCCGGGTCCACCGGGCCCCCGAGCCTTATAAAGCCCTCAGGGACCTGAAGGAGGCGCGGGGGCTTCTCGCCAAA

GACCTGAGCGTTCTGGCCCTGAGGGAAGGCCTTGGCCTCCCGCCCGGCGACGACCCCATGCTCCTCGCCTACCTCCT

GGACCCTTCCAACACCACCCCCGAGGGGGTGGCCCGGCGCTACGGCGGGGAGTGGACGGAGGAGGCGGGGGAGCGGG

CCGCCCTTTCCGAGAGGCTCTTCGCCAACCTGTGGGGGAGGCTTGAGGGGGAGGAGAGGCTCCTTTGGCTTTACCGG

GAGGTGGAGAGGCCCCTTTCCGCTGTCCTGGCCCACATGGAGGCCACGGGGGTGCGCCTGGACGTGGCCTATCTCAG

GGCCTTGTCCCTGGAGGTGGCCGAGGAGATCGCCCGCCTCGAGGCCGAGGTCTTCCGCCTGGCCGGCCACCCCTTCA

ACCTCAACTCCCGGGACCAGCTGGAAAGGGTCCTCTTTGACGAGCTAGGGCTTCCCGCCATCGGCAAGACGGAGAAG

ACCGGCAAGCGCTCCACCAGCGCCGCCGTCCTGGAGGCCCTCCGCGAGGCCCACCCCATCGTGGAGAAGATCCTGCA

GTACCGGGAGCTCACCAAGCTGAAGAGCACCTACATTGACCCCTTGCCGGACCTCATCCACCCCAGGACGGGCCGCC

TCCACACCCGCTTCAACCAGACGGCCACGGCCACGGGCAGGCTAAGTAGCTCCGATCCCAACCTCCAGAACATCCCC

GTACGCACCCCGCTTGGGCAGAGGATCCGCCGGGCCTTCATCGCCGAGGAGGGGTGGCTATTGGTGGCCCTGGACTA

TAGCCAGAAAGAGCTCAGGGTGCTGGCCCACCTCTCCGGCGACGAGAACCTGATCCGGGTCTTCCAGGAGGGGCGGG

ACATCCACACGGAGACCGCCAGCTGGATGTTCGGGGTCCCGCGGGAGGCCGTGGACCCCCTGATGCGCCGGGCGGCC

AAGACCATCAACTTCGGGGTCCTCTACGGCATGTCGGCCCACCGCCTCTCCCAGGAGCTAGCCATCCCTTACGAGGA

GGCCCAGGCCTTCATTGAGCGCTACTTTCAGAGCTTCCCCAAGGTGCGGGCCTGGATTGAGAAGACCCTGGAGGAGG

GCAGGAGGCGGGGGTACGTGGAGACCCTCTTCGGCCGCCGCCGCTACGTGCCAGACCTAGAGGCCCGGGTGAAGAGC

GGTGAAGCTCTTCCCCAGGCTGGAGGAAATGGGGGCCAGGATGCTCCTTCAGGTCCACGACGAGCTGGTCCTCGAGG CCCCAAAAGAGAGGGCGGAGGCCGTGGCCCGGCTGGCCAAGGAGGTCATGGAGGGGGTGTATCCCCTGGCCGTGCCC CTGGAGGTGGAGGTGGGGATAGGGGAGGACTGGCTCTCCGCCAAGGAGTGA

SEQ ID NO: 780

MGGSHHHHHHGMARMTGGQQMGRDLYDDDDKMRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYG FAKSLLKALKEDGDAVIWFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLA SLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIG

EVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEK TGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIP VRTPLGQRIRRAFIAEEGWLLVALDYSQKELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAA KTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP LEVEVGIGEDWLSAKE*

SEQ ID NO: 781 ATGGGGGGTTCTCATCATCATCATCATCATGGTATGGCTAGAATGACTGGTGGACAGCAAATGGGTCGGGATCTGTA

ACCTGGCCTACCGCACCTTCCACGCCCTGAAGGGCCTCACCACCAGCCGGGGGGAGCCGGTGCAGGCGGTCTACGGC

CTTCCGCCACGAGGCCTACGGGGGGTACAAGGCGGGCCGGGCCCCCACGCCGGAGGACTTTCCCCGGCAACTCGCCC TCATCAAGGAGCTGGTGGACCTCCTGGGGCTGGCGCGCCTCGAGGTCCCGGGCTACGAGGCGGACGACGTCCTGGCC

TTCCGACCGCATCCACGTCCTCCACCCCGAGGGGTACCTCATCACCCCGGCCTGGCTTTGGGAAAAGTACGGCCTGA GGCCCGACCAGTGGGCCGACTACCGGGCCCTGACCGGGGACGAGTCCGACAACCTTCCCGGGGTCAAGGGCATCGGG GAGAAGACGGCGAGGAAGCTTCTGGAGGAGTGGGGGAGCCTGGAAGCCCTCCTCAAGAACCTGGACCGGCTGAAGCC CGCCATCCGGGAGAAGATCCTGGCCCACATGGACGATCTGAAGCTCTCCTGGGACCTGGCCAAGGTGCGCACCGACC TGCCCCTGGAGGTGGACTTCGCCAAAAGGCGGGAGCCCGACCGGGAGAGGCTTAGGGCCTTTCTGGAGAGGCTTGAG TTTGGCAGCCTCCTCCACGAGTTCGGCCTTCTGGAAAGCCCCAAGGCCCTGGAGGAGGCCCCCTGGCCCCCGCCGGA

GGGGCCGGGTCCACCGGGCCCCCGAGCCTTATAAAGCCCTCAGGGACCTGAAGGAGGCGCGGGGGCTTCTCGCCAAA GACCTGAGCGTTCTGGCCCTGAGGGAAGGCCTTGGCCTCCCGCCCGGCGACGACCCCATGCTCCTCGCCTACCTCCT GGACCCTTCCAACACCACCCCCGAGGGGGTGGCCCGGCGCTACGGCGGGGAGTGGACGGAGGAGGCGGGGGAGCGGG CCGCCCTTTCCGAGAGGCTCTTCGCCAACCTGTGGGGGAGGCTTGAGGGGGAGGAGAGGCTCCTTTGGCTTTACCGG GAGGTGGAGAGGCCCCTTTCCGCTGTCCTGGCCCACATGGAGGCCACGGGGGTGCGCCTGGACGTGGCCTATCTCAG GGCCTTGTCCCTGGAGGTGGCCGAGGAGATCGCCCGCCTCGAGGCCGAGGTCTTCCGCCTGGCCGGCCACCCCTTCA ACCTCAACTCCCGGGACCAGCTGGAAAGGGTCCTCTTTGACGAGCTAGGGCTTCCCGCCATCGGCAAGACGGAGAAG ACCGGCAAGCGCTCCACCAGCGCCGCCGTCCTGGAGGCCCTCCGCGAGGCCCACCCCATCGTGGAGAAGATCCTGCA Table9(cont.)

GTACeGiSGAGCTCΑ^'CC^G^'iΛGΑ^Gkδϋii.όCfACATTGACCCCTTGCCGGACCTCATCCACCCCAGGACGGσCCGCC TCCACACCCGCTTCAACCAGACGGCCACGGCCACGGGCAGGCTAAGTAGCTCCGATCCCAACCTCCAGAACATCCCC ATCCGCACCCCGCTTGGGCAGAGGATCCGCCGGGCCTTCATCGCCGAGGAGGGGTGGCTATTGGTGGCCCTGGACTA TAGCCAGATAGAGCTCAGGGTGCTGGCCCACCTCTCCGGCGACGAGAACCTGATCCGGGTCTTCCAGGAGGGGCGGG ACATCCACACGGAGACCGCCAGCTGGATGTTCGGGGTCCCGCGGGAGGCCGTGGACCCCCTGATGCGCCGGGCGGCC

GGCCCAGGCCTTCATTGAGCGCTACTTTCAGAGCTTCCCCAAGGTGCGGGCCTGGATTGAGAAGACCCTGGAGGAGG GCAGGAGGCGGGGGTACGTGGAGACCCTCTTCGGCCGCCGCCGCTACGTGCCAGACCTAGAGGCCCGGGTGAAGAGC GTGCGGGAGGCGGCCGAGCGCATGGCCTTCAACATGCCCGTCCAGGGCACCGCCGCCGACCTCATGAAGCTGGCTAT GGTGAAGCTCTTCCCCAGGCTGGAGGAAATGGGGGCCAGGATGCTCCTTCAGGTCCACGACGAGCTGGTCCTCGAGG CCCCAAAAGAGAGGGCGGAGGCCGTGGCCCGGCTGGCCAAGGAGGTCATGGAGGGGGTGTATCCCCTGGCCGTGCCC CTGGAGGTGGAGGTGGGGATAGGGGAGGACTGGCTCTCCGCCAAGGAGTGA

SEQ ID NO: 782

MGGSHHHHHHGMARMTGGQQMGRDLYDDDDKMRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYG FAKSLLKALKEDGDAVIWFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLA SLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIG

FGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAK

EVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEK TGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIP IRTPLGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAA KTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP LEVEVOIGEDWLSAKE*

SEQ ID NO: 783

TTCGCCAAGAGCCTCCTCAAGGCCCTCAAGGAGGACGGGGACGCGGTGATCGTGGTCTTTGACGCCAAGGCCCCCTC TCATCAAGGAGCTGGTGGACCTCCTGGGGCTGGCGCGCCTCGAGGTCCCGGGCTACGAGGCGGACGACGTCCTGGCC TTCCGACCGCATCCACGTCCTCCACCCCGAGGGGTACCTCATCACCCCGGCCTGGCTTTGGGAAAAGTACGGCCTGA

GAGAAGACGGCGAGGAAGCTTCTGGAGGAGTGGGGGAGCCTGGAAGCCCTCCTCAAGAACCTGGACCGGCTGAAGCC CGCCATCCGGGAGAAGATCCTGGCCCACATGGACGATCTGAAGCTCTCCTGGGACCTGGCCAAGGTGCGCACCGACC

TTTGGCAGCCTCCTCCACGAGTTCGGCCTTCTGGAAAGCCCCAAGGCCCTGGAGGAGGCCCCCTGGCCCCCGCCGGA GGGGCCGGGTCCACCGGGCCCCCGAGCCTTATAAAGCCCTCAGGGACCTGAAGGAGGCGCGGGGGCTTCTCGCCAAA GGACCCTTCCAACACCACCCCCGAGGGGGTGGCCCGGCGCTACGGCGGGGAGTGGACGGAGGAGGCGGGGGAGCGGG GAGGTGGAGAGGCCCCTTTCCGCTGTCCTGGCCCACATGGAGGCCACGGGGGTGCGCCTGGACGTGGCCTATCTCAG ACCTCAACTCCCGGGACCAGCTGGAAAGGGTCCTCTTTGACGAGCTAGGGCTTCCCGCCATCGGCAAGACGGAGAAG

GTACCGGGAGCTCACCAAGCTGAAGAGCACCTACATTGACCCCTTGCCGGACCTCATCCACCCCAGGACGGGCCGCC TCCACACCCGCTTCAACCAGACGGCCACGGCCACGGGCAGGCTAAGTAGCTCCGATCCCAACCTCCAGAACATCCCC GTACGCACCCCGCTTGGGCAGAGGATCCGCCGGGCCTTCATCGCCGAGGAGGGGTGGCTATTGGTGGCCCTGGACTA TAGCCAGTGGGAGCTCAGGGTGCTGGCCCACCTCTCCGGCGACGAGAACCTGATCCGGGTCTTCCAGGAGGGGCGGG ACATCCACACGGAGACCGCCAGCTGGATGTTCGGGGTCCCGCGGGAGGCCGTGGACCCCCTGATGCGCCGGGCGGCC AAGACCATCAACTTCGGGGTCCTCTACGGCATGTCGGCCCACCGCCTCTCCCAGGAGCTAGCCATCCCTTACGAGGA GGCCCAGGCCTTCATTGAGCGCTACTTTCAGAGCTTCCCCAAGGTGCGGGCCTGGATTGAGAAGACCCTGGAGGAGG GCAGGAGGCGGGGGTACGTGGAGACCCTCTTCGGCCGCCGCCGCTACGTGCCAGACCTAGAGGCCCGGGTGAAGAGC GTGCGGGAGGCGGCCGAGCGCATGGCCTTCAACATGCCCGTCCAGGGCACCGCCGCCGACCTCATGAAGCTGGCTAT GGTGAAGCTCTTCCCCAGGCTGGAGGAAATGGGGGCCAGGATGCTCCTTCAGGTCCACGACGAGCTGGTCCTCGAGG Table9(cont.)

CCCCAAflAGAGAGGGCGGAGGCCGTGGCCCGGCTGGCCAAGGAGGTCATGGAGGGGGTGTATCCCCTGGCCGTGCCC CTGGAGGTGGAGGTGGGGATAGGGGAGGACTGGCTCTCCGCCAAGGAGTGA

SEQ ID NO: 784

MGGSHHHHHHGMARMTGGQQMGRDLYDDDDKMRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYG FAKSLLKALKEDGDAVIWFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLA SLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWADYRALTGDESDNLPGVKGIG EKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLKLSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLE FGSLLHEFGLLESPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAK DLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYR EVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAIGKTEK TGKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIP VRTPLGQRIRRAFIAEEGWLLVALDYSQWELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRRAA KTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVP LEVEVGIGEDWLSAKE*

Claims

WHAT IS CLAIMED IS

L A mutant DNA polymerase, wherein the amino acid sequence of the phosphate region of said mutant DNA polymerase comprises two or more mutations not present in the phosphate region of the most closely related native DNA polymerase, and wherein said two or more phosphate region mutations increase the rate at which said mutant DNA polymerase incorporates a phosphate-labeled nucleotide.

2 . The mutant DNA polymerase of claim 1, wherein said mutant DNA polymerase, or at least the phosphate region of said mutant polymerase, is derived from a Family A or Family B polymerase.

3. The mutant DNA polymerase of claim 2, wherein said mutant polymerase is a Family B polymerase. .

4. The mutant DNA polymerase of claim 3, wherein said mutant polymerase is a 9°N DNA polymerase.

5. The mutant DNA polymerase of claim 4, wherein said mutant 9°N DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to 9°N-A485L DNA polymerase (SEQ ID NO: 2); and wherein said mutant 9⁰N DNA polymerase comprises an alanine to leucine mutation at amino acid position 485; and wherein said mutant 9⁰N DNA polymerase further comprises one or more additional mutations in the phosphate region of said mutant 9⁰N DNA polymerase.

6. The mutant 9°N DNA polymerase of claim 5, wherein said one or more additional mutations are selected from the group consisting of a mutation at amino acid position 352, 355, 408, 460, 461, 464, 480, 483, 484, and 497, and combinations thereof.

7. The mutant 9°N DNA polymerase of claim 5, wherein said one or more additional mutations comprises a mutation at amino acid position 484.

8. The mutant 9°N DNA polymerase of claim 5, wherein said one or more additional mutations includes mutations at amino acid positions 408, 464, and 484.

9. The mutant 9°N DNA polymerase of claim 8, wherein said mutation at position 408 is selected from the group consisting of tryptophan, glutamine, histidine glutamic acid, methionine, asparagine, lysine, and alanine; and wherein said mutation at position 464 is selected from the group consisting of glutamic acid and proline; and wherein said mutation at position 485 is tryptophan.

10. The mutant 9⁰N DNA polymerase of claim 8, wherein said amino acids at positions 408, 464, and 484 are tryptophan, glutamic acid, and tryptophan, respectively.

11. The mutant 9⁰N DNA polymerase of claim 5, wherein said mutant 9°N DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to 9°N-A485L DNA polymerase (SEQ ID NO: 2), and wherein said rate is at least three times faster than that catalyzed by 9°N-A485L DNA polymerase.

12. The mutant 9⁰N DNA polymerase of claim 5, wherein said mutant 9°N DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to 9°N-A485L DNA polymerase (SEQ ID NO: 2), and wherein said rate is at least seven times faster than that catalyzed by 9°N-A485L DNA polymerase.

13. The mutant 9°N DNA polymerase of claim 5, wherein said mutant 9°N DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to 9°N-A485L DNA polymerase (SEQ ID NO: 2), and wherein said rate is at least twenty times faster than that catalyzed by 9°N-A485L DNA polymerase.

14. The mutant 9°N DNA polymerase of claim 5, wherein said mutant 9°N DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to 9°N-A485L DNA polymerase (SEQ ID NO: 2), and wherein said rate is at least fifty times faster than that catalyzed by 9°N-A485L DNA polymerase.

15. The mutant 9°N DNA polymerase of SEQ ID NO. 568.

16. The mutant 9°N DNA polymerase of SEQ ID NO. 568, further comprising one or more additional mutations, wherein said one or more additional mutations are selected from the group consisting of an alteration in amino acid identity, an insertion of one or more amino acids, and the deletion of one or more amino acids.

17. The mutant 9°N DNA polymerase of SEQ ID NO. 568 and conservative modifications thereof.

18. The mutant 9°N DNA polymerase of claim 17, further comprising one or more additional mutations, wherein at least one additional mutation is in the phosphate region of said mutant 9⁰N DNA polymerase.

19. The mutant 9°N DNA polymerase of claim 18, wherein the additionally mutated amino acid is selected from the group consisting of the asparagine at position 491 and lysine at position 487.

20. A mutant 9⁰N DNA polymerase with an amino acid sequence selected from the group consisting of the even-numbered SEQ ID NOs 4 through 750.

21. A purified nucleic acid sequence encoding a polymerase of claim 20.

22. A method for identifying polymerases with improved suitability for a nucleotide sequencing process, wherein the improved suitability is measured relative to that of a parent polymerase, comprising: (1) assaying the rate of phosphate-labeled nucleotide incorporation by a test mutant polymerase, wherein said phosphate region of said test polymerase is at least 90% identical to said parent polymerase; (2) determining if said rate of phosphate-labeled nucleotide incorporation by said test mutant polymerase is suitable for said nucleotide sequencing process; and, if said rate of phosphate-labeled nucleotide incorporation is suitable, then identifying the test mutant polymerase as such.

23. The method of claim 22, wherein if said rate of phosphate-labeled nucleotide incorporation is not suitable, repeating steps (1) and (2) with a second test mutant polymerase until a suitable polymerase is identified.

24. The method of claim 23, wherein said second test mutant comprises each of the mutations in the previous test mutant polymerase, and further comprises at least one additional mutation relative to the previous test mutant polymerase.

25 . The method of claim 22, wherein said polymerase is a thermostable polymerase.

26. The method of claim 22, wherein the amino acid sequence of said parent polymerase is at least 90% identical to the amino acid sequence of 9°N-A485L DNA polymerase (SEQ ID NO: 2).

27. The method of claim 22, wherein the amino acid sequence of said parent polymerase is at least 95% identical to the amino acid sequence of 9°N-A485L DNA polymerase (SEQ ID NO: 2).

28. The method of claim 26, wherein said improved polymerase is a polymerase which incorporates between 1 and 20 phosphate-labeled nucleotides per second.

29. The method of claim 28, wherein said improved polymerase is a polymerase which incorporates between 5 and 15 phosphate-labeled nucleotides per second.

30. The method of claim 29, wherein said nucleotide sequencing process is a field-switch polynucleotide sequencing process.

31. A mutant polymerase identified by the method of claim 24.

32. A mutant polymerase identified by the method of claim 27.

33. A mutant DNA polymerase, wherein the amino acid sequence of the phosphate region of said mutant DNA polymerase comprises one or more mutations not present in the phosphate region of the most closely related native DNA polymerase, and wherein said one or more phosphate region mutations increase the rate at which said mutant DNA polymerase incorporates a phosphate-labeled nucleotide.

34. The mutant DNA polymerase of claim 33, wherein said mutant DNA polymerase is a Family A DNA polymerase.

35. The mutant DNA polymerase of claim 35, wherein said mutant polymerase is a mutant Klenow DNA polymerase.

36. The mutant DNA polymerase of claim 35, wherein said mutant Klenow polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to the Klenow DNA polymerase of SEQ ID NO: 752; and wherein said mutant Klenow DNA polymerase comprises one or more phosphate region mutations.

37. The mutant Klenow DNA polymerase of claim 36, wherein said one or more additional mutations are selected from the group consisting of a mutation at amino acid position 423 and 504, and combinations thereof.

38. The mutant Klenow DNA polymerase of claim 37, wherein the amino acid at position 423 is mutated.

39. The mutant Klenow DNA polymerase of claim 38, wherein the amino acid at position 504 is mutated.

40. The mutant Klenow DNA polymerase of claim 39, wherein the amino acid at position 423 is lysine or glutamic acid.

41. The mutant Klenow DNA polymerase of claim 40, wherein the amino acid at position 504 is glycine.

42. The mutant Klenow DNA polymerase of claim 41 , wherein said mutant polymerase incorporates phosphate-labeled nucleotides at a rate at least three times faster than the Klenow polymerase of SEQ ID NO: 752.

43. The mutant Klenow DNA polymerase of SEQ ID NO: 756, 758, or 764.

44. A purified nucleotide acid encoding a mutant Klenow DNA polymerase of claim 43.

45. The mutant DNA polymerase of claim 34, wherein said mutant polymerase is a mutant Taq DNA polymerase.

46. The mutant DNA polymerase of claim 43, wherein said mutant Taq DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to the Taq DNA polymerase of SEQ ID NO: 766; and wherein said mutant Taq DNA polymerase comprises one or more phosphate region mutations.

47. The mutant Taq DNA polymerase of claim 46, wherein said one or more additional mutations are selected from the group consisting of a mutation at amino acid positions 589, 617, 645, 691, 673, and 726, and combinations thereof.

48. The mutant Taq DNA polymerase of claim 47, wherein the amino acid at position 617 is isoleucine. . ,

49. The mutant Taq DNA polymerase of claim 47, wherein the amino acid at position 645 is selected from the group consisting of histidine, phenylalanine, lysine and tryptophan.

50. The mutant Taq DNA polymerase of claim 47, wherein the amino acid at position 691 is tyrosine.

51. The mutant Taq DNA polymerase of claim 47, wherein the amino acid at position 693 is glycine.

52. The mutant Taq DNA polymerase of claim 47, wherein the amino acid at position 726 is serine.

53. The mutant Taq DNA polymerase of claim 47, wherein the amino acid at position 589 is aspartic acid and the amino acid at position 645 is histidine.

54. The mutant Taq DNA polymerase of claim 47, wherein said mutant polymerase incorporates phosphate-labeled nucleotides at a rate at least two times faster than the Taq polymerase of SEQ ID NO: 766.

55. The mutant Taq DNA polymerase of claim 47, wherein said mutant polymerase incorporates phosphate-labeled dinucleotides at a rate between five and fifteen times faster than the Taq polymerase of SEQ ID NO: 766.

56. The mutant Taq DNA polymerase of SEQ ID NO: 768, 770, 772, 774, 776, 778, 780, 782 or 784.

57. A purified nucleic acid encoding a mutant Taq DNA polymerase of claim 56.

58. ' A mutant DNA polymerase selected from the group consisting of the mutant DNA polymerases represented by the even-numbered sequences of SEQ ID NOs: 4- 750, 754-764, and 768-784.

59. A mutant DNA polymerase wherein the phosphate region of said mutant DNA polymerase is identical to the phosphate region of a polymerase selected from the group consisting of the mutant DNA polymerases represented by the even-numbered sequences of SEQ ID NOs: 4-750, 754-764, and 768-784.

60. A mutant DNA polymerase selected from the group consisting of the mutant DNA polymerases represented by the even-numbered sequences of SEQ ED NOs: 4- 750, wherein said mutant DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to the DNA polymerase of SEQ ID NO: 2.

61. A mutant DNA polymerase selected from the group consisting of the mutant DNA polymerases represented by the even-numbered sequences of SEQ ID NOs: 754-764, wherein said mutant DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to the DNA polymerase of SEQ ID NO: 752.

62. A mutant DNA polymerase selected from the group consisting of the mutant DNA polymerases represented by the even-numbered sequences of SEQ ID NOs: 768-784, wherein said mutant DNA polymerase incorporates phosphate-labeled nucleotides at an increased rate relative to the DNA polymerase of SEQ ID NO: 766.

63. The mutant polymerase of claims 60, 61 or 62, further comprising at least one anchor for attachment to a solid surface.

64. The mutant polymerase of claim 63, wherein said polymerase has at least two anchors.

65. The mutant DNA polymerase of claim 63, wherein said mutant DNA polymerase is used for DNA sequencing and genotyping.

66. The mutant DNA polymerase of claim 65, wherein said DNA sequencing is selected from the group consisting of charge-switch sequencing and electrokinetic sequencing.

67. The mutant DNA polymerase of claim 65, wherein said DNA sequencing is single DNA molecule sequencing.

68. The mutant DNA polymerase of claim 65, wherein said DNA genotyping is single DNA molecule genotyping.

69. A method of DNA sequencing, said method comprising: (i) providing at least one complex comprising a target nucleic acid, a primer nucleic acid, and a mutant DNA polymerase; (ii) contacting the complex with a plurality of charged particles comprising at least one type of phosphate-labeled nucleotide triphosphate (NTP) by applying an electric field; (iii) reversing the electric field to transport unbound charged particles away from the surface; and (iv) detecting the incorporation of said at least one type of γ-phosphate- labeled NTP into a single molecule of the primer nucleic acid.

70. The method of claim 69, wherein said mutant DNA polymerase is selected from the group consisting of any of the mutants set forth in claims 5, 36, and 46.

71. The method of claim 69, wherein said phosphate-labeled NTP is a γ- phosphate-labeled NTP.

72. The method of claim 71, wherein said γ-phosphate-labeled NTP is further labeled with polyethylene glycol (PEG).