WO2006036122A1 - Injection syringe - Google Patents

Injection syringe Download PDF

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Publication number
WO2006036122A1
WO2006036122A1 PCT/SE2005/001443 SE2005001443W WO2006036122A1 WO 2006036122 A1 WO2006036122 A1 WO 2006036122A1 SE 2005001443 W SE2005001443 W SE 2005001443W WO 2006036122 A1 WO2006036122 A1 WO 2006036122A1
Authority
WO
WIPO (PCT)
Prior art keywords
injection
ampoule
dosage
protrusion
plunger rod
Prior art date
Application number
PCT/SE2005/001443
Other languages
French (fr)
Inventor
Gerhard Andersson
Original Assignee
Red Develop Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Red Develop Ab filed Critical Red Develop Ab
Priority to EP05787443A priority Critical patent/EP1804861A1/en
Publication of WO2006036122A1 publication Critical patent/WO2006036122A1/en
Priority to US11/690,899 priority patent/US20070219506A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2496—Ampoule holder connected to rest of syringe via pivot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members

Definitions

  • the present invention relates to disassembable injection syringe, in particular suited for diabetics for the injection of insulin.
  • injection administrations of different types are carried out using different injection syringes, which generally encompass a cylindrical space, " which at one end thereof is provided with or can be provided with an injection needle suitable to the type of injection intended (e.g. s.c, i.v., i.m., i.p.), and in the other end thereof is provided a plunger with a plunger rod connected thereto.
  • injection syringes which generally encompass a cylindrical space, " which at one end thereof is provided with or can be provided with an injection needle suitable to the type of injection intended (e.g. s.c, i.v., i.m., i.p.), and in the other end thereof is provided a plunger with a plunger rod connected thereto.
  • US patent 5,197,954 discloses an injection syringe in which the injection needle is present in a front part being provided with a hinge which can be pivoted up alongside the cylindrical space in order to thus reduce the risk of damage when one handles a used syringe.
  • US patent 4,011,868 discloses an injection syringe with plunger and plunger rod wherein the plunger rod can be bent backwards and be placed alongside the cylindrical space when the plunger is present in a rear position. The bending/pivoting takes place along a bending line arranged in a separation of the plunger rod. In the discl ⁇ sure it is also described that the injection needle unit can be introduced and stored in the plunger rod.
  • the object of the invention is to make it possible having pre-filled syringes without ' risking unintended spraying of injection liquid.
  • US-A-4,221,218 discloses a syringe having an ampoule part of a piece of straight glass or tube of inert material, a rubber plunger at the end of the ampoule part, a plunger rod part being tumable 180° including a joint to be joined to the rear end of the ampoule receiving the plunger.
  • GB-A-2,233,564 discloses a medical injection syringe having a plunger rod being tumable 180° as well in relation to a plunger provided, ampoule part.
  • WO97/29798 discloses an injection syringe having an ampoule, whereby the syringe comprises an axially extending body having an axially extending hollow opening arranged to receive an ampoule part, a connecting part at the distal end to receive an injection needle, a plunger device to be brought into the proximal end, whereby the plunger is attached to the proximal end of the syringe body to provide a pivotable joint, wherein the plunger and the longitudinal axis of the plunger is turned from a first position 180° to a second position in relation to the ampoule part and the longitudinal axis of the ampoule to be positioned in a position alongside the ampoule part to facilitate the use of the plunger part to the plunger of the ampoule.
  • injection syringes thus include system to join the plunger rod to the ampoule part by means of a turning 180° over a hinge joint.
  • insulin pens i.e., an injection syringe of disposable type containing a pre- filled ampoule and a head with a dosage device for adjustment of the correct dosage, which is determined by means of a blood glucose test, done by the diabetic himself.
  • the dose is also related to an expected body activity and meals.
  • the insulin pens are rather long and fits poorly in a pocket. Even jacket inside pockets may sometimes be too shallow, The mode of today also often dictates slimmed clothes where it is difficult to hide or event be able to place an insulin pen.
  • the present invention relates to a disassembable injection syringe comprising an ampoule part and a plunger rod/dosage part, which are placed in a sidewise relationship relative each other when the injection syringe is not in use, ad which are operated to be brought together in a common axial relationship in relation to each other at use.
  • the present invention is characterized in that an ampoule part containing a pre-filled amount of injection solution between an injection needle and a plunger, and a dosage unit containing a plunger rod, a device to adjust a dosage of injection solution and mechanism bringing the plunger rod forward, whereby the ampoule part and the dosage part are arranged releasably side-by-side parallel to each other in a first inactive position, and are arranged to be moved parallel axially relative each other adjustment into a coaxial position for an injection cooperation.
  • a preferred embodiment of the invention is characterized in that either of the ampoule part or the dosage part.
  • a preferred embodiment of the invention is characterized in that either of the ampoule part and the dosage part comprises a groove for receiving a protrusion running in parallel with the longitudinal axis of the ampoule part, or the dosage part, respectively, which protrusion is arranged dosage part, or the ampoule part, respectively, whereby the protrusion is axially displaceable and rotatable in said groove in order to bring the parts into a coaxial position in relation to each other.
  • a preferred embodiment of the invention is characterized in that the ampoule part and the dosage part comprise a pivotable lever system connecting the parts whereby the ampoule part is axially displaceable and rotatable in relation to said dosage part to bring the parts into a coaxial position relative each other, whereby the longitudinal axis of the ampoule part, and the longitudinal axis of the dosage part, respectively, are arranged to be displaced parallel axially relative each other by means of the lever system to adjustment into a coaxial position for injection cooperation.
  • Another preferred embodiment of the invention is characterized in that the syringe is intended for single use.
  • a further preferred embodiment of the invention is characterized in tht the syringe is arranged to receive an exchangeable ampoule containing an injection solution.
  • Another further preferred embodiment of the invention is characterized in that the syringe is particularly suited for diabetics for the injection of insulin.
  • FIG. 1 shows a first embodiment of an injection syringe according to the present invention arranged in a sidewise relationship.
  • FIG. 2 shows the injection syringe according to FIG. 1 in a cross-section along the line II-II
  • FIG. 3 shows the injection syringe according to FIG. 1 during joining to one unit
  • FIG. 4 shows the injection syringe according to FIG. 1 in a joined condition
  • FIG. 5 shows an injection syringe according to FIG. 1 having an outer envelope
  • FIG. 6 shows a second embodiment of an injection syringe of the present invention arranged in a sidewise relationship
  • FIG. 7 shows the injection syringe according to FIG. 6 in a cross-section along the line VII-
  • FIG. 7a shows the injection syringe according to FIG. 7 in a cross-section along line VII-VII in a partly open condition
  • FIG. 8 shows a variety of the injection syringe according to FIG. 6 in a cross-section along the line VII-VII
  • FIG. 10 shows a third embodiment of an injection syringe according to the present invention arranged in a sidewise relationship
  • FIG. 11 and 14 show the injection syringe according to FIG. 10 during joining to one unit
  • FIG. 12 shows one part of the injection syringe according to FIG. 10 to provide for a joined condition
  • FIG. 13 shows a second part of the injection syringe according to FIG. 10 to provide for a joined condition
  • FIG. 15 shows a detail of an injection syringe according to a further embodiment in a cross-section
  • FIG. 16 shows a detail of an injection syringe according to a further embodiment in a cross-section.
  • 1 denotes generally a disassembable injection syringe according to the present invention.
  • the injection syringe comprises an ampoule part 2 and a plunger rod/dosage part 3.
  • the ampoule part 2 is generally provided with, at its front end 4, an injection needle (in the picture the needle is protected by a needle protecting shield 5) of such a type being suited for the injection to be carried out, i.e., quite often a thin cannula used for subcutaneous injections och coarser cannulas for e.g., intra muscular injections.
  • the ampoule part 2 is completely or partly transparent so that its content can be controlled visually.
  • a plunger 6 is arranged which is arranged to receive or in any other way cooperate with a plunger rod 7 which will be described in closer detail below.
  • the plunger rod/dosage part 3 comprises a housing 8 which encloses a plunger rod 7 wgich is fed/moved forward via a thread system (not shown).
  • the thread system comprises an adjustment mechanism which means that a certain forward movement can be carried out after adjustment in order to administer a certain, predetermined dose when the plunger rod 7 is being moved forward.
  • the thread mechanism contains such a function, as well, that the plunger rod can be retracted to a zero-position in order to be able to be brought forward to a prior final point of injection.
  • the thread mechanism comprises an outer injection trigger, which at an axial pressure, activates the plunger rod/plunger to be fed a determined length.
  • the ampoule part 2 has along its side a peripherally, axially to the longitudinal axis of the ampoule extending groove 9.
  • a peripherally extending protrusion 10, corresponding to the groove 9, is running.
  • the groove 9 is arranged to receive the protrusion 10 and is arranged in such a way that the protrusion 10 using simple hand power can be moved in the groove 9 (FIG. 3), whereupon the plunger rod/dosage unit 3 is turned around the protrusion 10 in the groove 9 in a plane perpendicular to the longitudinal axis of the plunger rod part, such that this will axially coincide with the ampoule part 2, whereupon the parts 2 and 3 are removably attached to each other.
  • the protrusion 10 has a length exceeding the length of the groove 9 such that the protrusion remains in the groove 9 during the turning operation, and will thereby become a guide to the turning over.
  • a predetermined injection dosage is adjusted whereby the plunger rod 7 is introduced into the ampoule part 2 and is connected to the plunger 6, the injection trigger is actuated and injection is made in an intended way.
  • the plunger rod/dosage part 3 is released and is turned back to a sidewise position and is moved down along the ampoule part 2 to form a compact unit.
  • the unit can be received in an envelope 11 if so desired.
  • the envelope 11 snaps around the injection syringe in a compressed, compact condition so that the plunger rod/dosage part 3 can be moved up and be placed over the ampoule part 2.
  • FIG. 6 shows a second embodiment of the invention where the groove 9, and the protrusion 10 respectively are placed in the respective corner of the housings of the ampoule part 2 and the plunger rod/dosage part 3, respectively.
  • a hook 21 is arranged which is either an outer hook 21 or an inner catch 22 locking the parts to each other in a compact position.
  • the respective parts have opposing plane surfaces 23 and 24 respectively.
  • a part envelope 12 receiving the lower, needle provided end 4 of the ampoule part 2, and an upper part of the upper part of the plunger rod/dosage part 3 in a compact position.
  • an exchangeable ampoule 31 can be used whereby the ampoule 31 is either loaded from above, i.e., axially into the ampoule part: or is introduced sidewise, radially into the ampoule part 2.
  • the whole side of the ampoule 2 can be a snap holder to retain the ampoule 31 or may the edge of the sidewise opened ampoule part 2 be provided with tongues/protrusions 51 forming snaps to retain the ampoule 31.
  • FIG. 10 shows a further embodiment of the invention where the ampoule part and the dosage part are joined using alever system 41.
  • a lever arm 42 is rotatably arranged between the two parts and is arranged to the respective part via a rotation axis 43 and 44 on the respective part 2, 3.
  • the parts 2, 3 are placed alongside each other, and at use the lever arm 42 and the ampoule part 2 are turned outwards so that the ampoule part 2 will be placed coaxially to the dosage part 3.
  • the lever arm has in connection with each rotation axis a cross section making them abutting the respective part to lock the same, while at the middle thereof it has a cross-section which makes it locks the parts when the coincide axially.
  • the ampoule part 2 can be introduced along an arrow towards the ampoule part or be turned simultaneously 18Oo (FIG. 11) to arrive towards the plunger rod part 3.
  • FIG. 15 shows a cross-section of an embodiment wherein the groove 9 is a more integrated part of e.g., the ampoule wall and wherein the ampoule wall and the wall of the plunger rod run against each other over a considerable surface area.
  • This embodiment forms a well coherent shape having a substantially integrated outer contour.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The present invention relates to a disassembable injection syringe (1), in particularly suited for diabetics for the administration of insulin, whereby an ampoule part (2) containing a pre-filled amount of injection solution between an injection needle and a plunger (6), and a dosage unit (3) containing a plunger rod (7), a device to adjust a dosage of injection solution and mechanism bringing the plunger rod (7) forward, whereby the ampoule part (2) and the dosage part (3) are arranged releasably side-by-side parallel to each other in a first inactive position, and are arranged to be moved parallel axially relative each other adjustment into a coaxial position for an injection cooperation.

Description

TITLE
INJECTION SYRINGE
DESCRIPTION
Technical field
The present invention relates to disassembable injection syringe, in particular suited for diabetics for the injection of insulin.
Background of the invention
Injection administrations of different types are carried out using different injection syringes, which generally encompass a cylindrical space, "which at one end thereof is provided with or can be provided with an injection needle suitable to the type of injection intended (e.g. s.c, i.v., i.m., i.p.), and in the other end thereof is provided a plunger with a plunger rod connected thereto.
In most cases an injection solution is drawn up from a bottle /vial) into the cylindrical space prior to an injection or an ampoule is connected into a cylindrical space.bejng a syringe body, into which the plunger rod is arranged to operate. A great number of different solutions of the design of injection syringes have thus been proposed during the years. . .
US patent 5,197,954 discloses an injection syringe in which the injection needle is present in a front part being provided with a hinge which can be pivoted up alongside the cylindrical space in order to thus reduce the risk of damage when one handles a used syringe.
US patent 4,011,868 discloses an injection syringe with plunger and plunger rod wherein the plunger rod can be bent backwards and be placed alongside the cylindrical space when the plunger is present in a rear position. The bending/pivoting takes place along a bending line arranged in a separation of the plunger rod. In the discløsure it is also described that the injection needle unit can be introduced and stored in the plunger rod. The object of the invention is to make it possible having pre-filled syringes without' risking unintended spraying of injection liquid. US-A-4,221,218 discloses a syringe having an ampoule part of a piece of straight glass or tube of inert material, a rubber plunger at the end of the ampoule part, a plunger rod part being tumable 180° including a joint to be joined to the rear end of the ampoule receiving the plunger.
GB-A-2,233,564 discloses a medical injection syringe having a plunger rod being tumable 180° as well in relation to a plunger provided, ampoule part.
WO97/29798 discloses an injection syringe having an ampoule, whereby the syringe comprises an axially extending body having an axially extending hollow opening arranged to receive an ampoule part, a connecting part at the distal end to receive an injection needle, a plunger device to be brought into the proximal end, whereby the plunger is attached to the proximal end of the syringe body to provide a pivotable joint, wherein the plunger and the longitudinal axis of the plunger is turned from a first position 180° to a second position in relation to the ampoule part and the longitudinal axis of the ampoule to be positioned in a position alongside the ampoule part to facilitate the use of the plunger part to the plunger of the ampoule.
These injection syringes thus include system to join the plunger rod to the ampoule part by means of a turning 180° over a hinge joint.
To diabetics who have to inject themselves several times a day with a solution of insulin and thereby permanently have to bring with them a syringe or syringes there is today that which is called insulin pens, i.e., an injection syringe of disposable type containing a pre- filled ampoule and a head with a dosage device for adjustment of the correct dosage, which is determined by means of a blood glucose test, done by the diabetic himself. The dose is also related to an expected body activity and meals. The insulin pens are rather long and fits poorly in a pocket. Even jacket inside pockets may sometimes be too shallow, The mode of today also often dictates slimmed clothes where it is difficult to hide or event be able to place an insulin pen.
Many insulin pens are besides, rather coarse i.e., have a significant diameter Summary of the present invention
The present invention relates to a disassembable injection syringe comprising an ampoule part and a plunger rod/dosage part, which are placed in a sidewise relationship relative each other when the injection syringe is not in use, ad which are operated to be brought together in a common axial relationship in relation to each other at use.
In particular the present invention is characterized in that an ampoule part containing a pre-filled amount of injection solution between an injection needle and a plunger, and a dosage unit containing a plunger rod, a device to adjust a dosage of injection solution and mechanism bringing the plunger rod forward, whereby the ampoule part and the dosage part are arranged releasably side-by-side parallel to each other in a first inactive position, and are arranged to be moved parallel axially relative each other adjustment into a coaxial position for an injection cooperation.
A preferred embodiment of the invention is characterized in that either of the ampoule part or the dosage part.
A preferred embodiment of the invention is characterized in that either of the ampoule part and the dosage part comprises a groove for receiving a protrusion running in parallel with the longitudinal axis of the ampoule part, or the dosage part, respectively, which protrusion is arranged dosage part, or the ampoule part, respectively, whereby the protrusion is axially displaceable and rotatable in said groove in order to bring the parts into a coaxial position in relation to each other.
A preferred embodiment of the invention is characterized in that the ampoule part and the dosage part comprise a pivotable lever system connecting the parts whereby the ampoule part is axially displaceable and rotatable in relation to said dosage part to bring the parts into a coaxial position relative each other, whereby the longitudinal axis of the ampoule part, and the longitudinal axis of the dosage part, respectively, are arranged to be displaced parallel axially relative each other by means of the lever system to adjustment into a coaxial position for injection cooperation.
Another preferred embodiment of the invention is characterized in that the syringe is intended for single use. A further preferred embodiment of the invention is characterized in tht the syringe is arranged to receive an exchangeable ampoule containing an injection solution.
Another further preferred embodiment of the invention is characterized in that the syringe is particularly suited for diabetics for the injection of insulin.
Detailed description of the present invention
The present invention will be described more in detail in the following with reference to the accompanying drawing, wherein FIG. 1 shows a first embodiment of an injection syringe according to the present invention arranged in a sidewise relationship.
FIG. 2 shows the injection syringe according to FIG. 1 in a cross-section along the line II-II
FIG. 3 shows the injection syringe according to FIG. 1 during joining to one unit
FIG. 4 shows the injection syringe according to FIG. 1 in a joined condition FIG. 5 shows an injection syringe according to FIG. 1 having an outer envelope
FIG. 6 shows a second embodiment of an injection syringe of the present invention arranged in a sidewise relationship
FIG. 7 shows the injection syringe according to FIG. 6 in a cross-section along the line VII-
VII FIG. 7a shows the injection syringe according to FIG. 7 in a cross-section along line VII-VII in a partly open condition
FIG. 8 shows a variety of the injection syringe according to FIG. 6 in a cross-section along the line VII-VII
FIG. 10 shows a third embodiment of an injection syringe according to the present invention arranged in a sidewise relationship
FIG. 11 and 14 show the injection syringe according to FIG. 10 during joining to one unit
FIG. 12 shows one part of the injection syringe according to FIG. 10 to provide for a joined condition
FIG. 13 shows a second part of the injection syringe according to FIG. 10 to provide for a joined condition
FIG. 15 shows a detail of an injection syringe according to a further embodiment in a cross-section
FIG. 16 shows a detail of an injection syringe according to a further embodiment in a cross-section. 1 denotes generally a disassembable injection syringe according to the present invention. The injection syringe comprises an ampoule part 2 and a plunger rod/dosage part 3.
The ampoule part 2 is generally provided with, at its front end 4, an injection needle (in the picture the needle is protected by a needle protecting shield 5) of such a type being suited for the injection to be carried out, i.e., quite often a thin cannula used for subcutaneous injections och coarser cannulas for e.g., intra muscular injections. The ampoule part 2 is completely or partly transparent so that its content can be controlled visually. In the rear part of the ampoule 2 a plunger 6 is arranged which is arranged to receive or in any other way cooperate with a plunger rod 7 which will be described in closer detail below.
The plunger rod/dosage part 3 comprises a housing 8 which encloses a plunger rod 7 wgich is fed/moved forward via a thread system (not shown). The thread system comprises an adjustment mechanism which means that a certain forward movement can be carried out after adjustment in order to administer a certain, predetermined dose when the plunger rod 7 is being moved forward. The thread mechanism contains such a function, as well, that the plunger rod can be retracted to a zero-position in order to be able to be brought forward to a prior final point of injection. Finally, the thread mechanism comprises an outer injection trigger, which at an axial pressure, activates the plunger rod/plunger to be fed a determined length.
The ampoule part 2 has along its side a peripherally, axially to the longitudinal axis of the ampoule extending groove 9. On the side of the plunger rod/dosage unit 3 a peripherally extending protrusion 10, corresponding to the groove 9, is running. The groove 9 is arranged to receive the protrusion 10 and is arranged in such a way that the protrusion 10 using simple hand power can be moved in the groove 9 (FIG. 3), whereupon the plunger rod/dosage unit 3 is turned around the protrusion 10 in the groove 9 in a plane perpendicular to the longitudinal axis of the plunger rod part, such that this will axially coincide with the ampoule part 2, whereupon the parts 2 and 3 are removably attached to each other. Hereby the protrusion 10 has a length exceeding the length of the groove 9 such that the protrusion remains in the groove 9 during the turning operation, and will thereby become a guide to the turning over. Then a predetermined injection dosage is adjusted whereby the plunger rod 7 is introduced into the ampoule part 2 and is connected to the plunger 6, the injection trigger is actuated and injection is made in an intended way. When the injection is finished the plunger rod is returned, the plunger rod/dosage part 3 is released and is turned back to a sidewise position and is moved down along the ampoule part 2 to form a compact unit. The unit can be received in an envelope 11 if so desired. The envelope 11 snaps around the injection syringe in a compressed, compact condition so that the plunger rod/dosage part 3 can be moved up and be placed over the ampoule part 2.
FIG. 6 shows a second embodiment of the invention where the groove 9, and the protrusion 10 respectively are placed in the respective corner of the housings of the ampoule part 2 and the plunger rod/dosage part 3, respectively. In the opposite corner of the plunger rod part 3 a hook 21 is arranged which is either an outer hook 21 or an inner catch 22 locking the parts to each other in a compact position. Hereby, the respective parts have opposing plane surfaces 23 and 24 respectively. In the embodiment shown there is a part envelope 12 receiving the lower, needle provided end 4 of the ampoule part 2, and an upper part of the upper part of the plunger rod/dosage part 3 in a compact position.
According to a variety of this embodiment (FIG. 16) an exchangeable ampoule 31 can be used whereby the ampoule 31 is either loaded from above, i.e., axially into the ampoule part: or is introduced sidewise, radially into the ampoule part 2. In the later case the whole side of the ampoule 2 can be a snap holder to retain the ampoule 31 or may the edge of the sidewise opened ampoule part 2 be provided with tongues/protrusions 51 forming snaps to retain the ampoule 31.
FIG. 10 shows a further embodiment of the invention where the ampoule part and the dosage part are joined using alever system 41. Hereby a lever arm 42 is rotatably arranged between the two parts and is arranged to the respective part via a rotation axis 43 and 44 on the respective part 2, 3. In a non-use position the parts 2, 3 are placed alongside each other, and at use the lever arm 42 and the ampoule part 2 are turned outwards so that the ampoule part 2 will be placed coaxially to the dosage part 3. The lever arm has in connection with each rotation axis a cross section making them abutting the respective part to lock the same, while at the middle thereof it has a cross-section which makes it locks the parts when the coincide axially. This means that one has a double snapping function, one in an inactive position, and one in an active position. Depending on the geometrical design of the lever system the ampoule part 2 can be introduced along an arrow towards the ampoule part or be turned simultaneously 18Oo (FIG. 11) to arrive towards the plunger rod part 3.
FIG. 15 shows a cross-section of an embodiment wherein the groove 9 is a more integrated part of e.g., the ampoule wall and wherein the ampoule wall and the wall of the plunger rod run against each other over a considerable surface area. This embodiment forms a well coherent shape having a substantially integrated outer contour.

Claims

1. A disassembable injection syringe (1), characterized in an ampoule part (2) containing a pre-filled amount of injection solution between an injection needle and a plunger (6), and a dosage unit (3) containing a plunger rod (7), a device to adjust a dosage of injection solution and mechanism bringing the plunger rod (7) forward, whereby the ampoule part (2) and the dosage part (3) are arranged releasably side-by-side parallel to each other in a first inactive position, and are arranged to be moved parallel axially relative each other adjustment into a coaxial position for an injection cooperation.
2. An injection syringe according to claim 1, characterized in that either of the ampoule part (2) or the dosage part (3) comprises a groove (9) for receiving a protrusion (10) running in parallel with the longitudinal axis of the ampoule part (2), or the dosage part (3), respectively, which protrusion (10) is arranged to the dosage part (3), or the ampoule part (2), respectively, whereby the protrusion (10) is axially displaceable.
3. An injection syringe according to claims 1-2, characterized in that either of the ampoule part (2) and the dosage part (3) comprises a groove (9) for receiving a protrusion (10) running in parallel with the longitudinal axis of the ampoule part (2), or the dosage part (3), respectively, which protrusion (10) is arranged to the dosage part (3), or the ampoule part (2), respectively, whereby the protrusion (10) is axially displaceable and rotatable in said groove (9) in order to bring the parts (2, 3) into a coaxial position in relation to each other.
4. An injection syringe according to claims 1-2, characterized in that the ampoule part (2) and the dosage part (3) comprise a pivotable lever system (41) connecting the parts
(2,3) whereby the ampoule part (2) is axially displaceable and rotatable in relation to said dosage part (3) to bring the parts (2, 3) into a coaxial position relative each other, whereby the longitudinal axis of the ampoule part (2), and the longitudinal axis of the dosage part (3), respectively, are arranged to be displaced parallel axially relative each other by means of the lever system (41) to adjustment into a coaxial position for injection cooperation.
5. An injection syringe according to claims 1-4, characterized in that the syringe is intended for single use.
6. An injection syringe according to one or more of claims 1-5, characterized in that the syringe is arranged to receive an exchangeable ampoule containing an injection solution.
7. An injection syringe according to one or more of claims 1-6, characterized in that the syringe is particularly suited for diabetics for the injection of insulin.
8. An injection syringe according to one or more of claims 1-7, characterized in that the ampoule part (2) and the dosage part (3) are contained in a connecting envelope.
PCT/SE2005/001443 2004-09-29 2005-09-29 Injection syringe WO2006036122A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05787443A EP1804861A1 (en) 2004-09-29 2005-09-29 Injection syringe
US11/690,899 US20070219506A1 (en) 2004-09-29 2007-03-26 Injection syringe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0402361A SE528173C2 (en) 2004-09-29 2004-09-29 Separable syringe
SE0402361-0 2004-09-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/690,899 Continuation US20070219506A1 (en) 2004-09-29 2007-03-26 Injection syringe

Publications (1)

Publication Number Publication Date
WO2006036122A1 true WO2006036122A1 (en) 2006-04-06

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ID=33414862

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Application Number Title Priority Date Filing Date
PCT/SE2005/001443 WO2006036122A1 (en) 2004-09-29 2005-09-29 Injection syringe

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US (1) US20070219506A1 (en)
EP (1) EP1804861A1 (en)
SE (1) SE528173C2 (en)
WO (1) WO2006036122A1 (en)

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EP2502643A1 (en) * 2011-03-22 2012-09-26 Sanofi-Aventis Deutschland GmbH Drug delivery device with pack size reduction
WO2013048870A1 (en) * 2011-09-30 2013-04-04 Becton Dickinson France S.A.S. Syringe having a removable cover for use as a plunger rod in rotational engagement
EP2214755A4 (en) * 2007-11-06 2015-09-09 Hospira Inc Injection device and method of assembly and activation

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JP2009518080A (en) * 2005-12-05 2009-05-07 中山博泰薬械有限公司 Automatic syringe
US8632519B2 (en) * 2009-08-21 2014-01-21 Becton Dickinson France, S.A.S. Syringe having a collapsible plunger rod
US8636702B2 (en) * 2009-08-21 2014-01-28 Beckton Dickinson France, S.A.S. Magnifying collapsed plunger rod
WO2011101651A1 (en) * 2010-01-19 2011-08-25 Cambridge Enterprise Limited Apparatus and methods

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US4221218A (en) * 1979-01-18 1980-09-09 Pfleger Frederick W Disposable hypodermic syringe
US4581023A (en) * 1985-02-12 1986-04-08 Kuntz David H Hypodermic syringe assembly
GB2233564A (en) * 1989-06-30 1991-01-16 Jonathan George Denham Medical syringe with linked barrel and plunger
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Publication number Priority date Publication date Assignee Title
EP2214755A4 (en) * 2007-11-06 2015-09-09 Hospira Inc Injection device and method of assembly and activation
EP2502643A1 (en) * 2011-03-22 2012-09-26 Sanofi-Aventis Deutschland GmbH Drug delivery device with pack size reduction
WO2013048870A1 (en) * 2011-09-30 2013-04-04 Becton Dickinson France S.A.S. Syringe having a removable cover for use as a plunger rod in rotational engagement
US8882719B2 (en) 2011-09-30 2014-11-11 Becton Dickinson France S.A.S. Syringe having a removable cover for use as a plunger rod in rotational engagement

Also Published As

Publication number Publication date
SE0402361D0 (en) 2004-09-29
SE0402361L (en) 2006-03-30
US20070219506A1 (en) 2007-09-20
EP1804861A1 (en) 2007-07-11
SE528173C2 (en) 2006-09-19

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