WO2006031764A3 - Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates - Google Patents

Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates Download PDF

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Publication number
WO2006031764A3
WO2006031764A3 PCT/US2005/032473 US2005032473W WO2006031764A3 WO 2006031764 A3 WO2006031764 A3 WO 2006031764A3 US 2005032473 W US2005032473 W US 2005032473W WO 2006031764 A3 WO2006031764 A3 WO 2006031764A3
Authority
WO
WIPO (PCT)
Prior art keywords
piperidines
processes
prepating
intermediates
substituted arylmethyl
Prior art date
Application number
PCT/US2005/032473
Other languages
French (fr)
Other versions
WO2006031764A2 (en
Inventor
Jaidev Goudar
David S Rosen
Guozhi Wang
Qun Zhang
Russell Patera
Original Assignee
Fmc Corp
Jaidev Goudar
David S Rosen
Guozhi Wang
Qun Zhang
Russell Patera
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Corp, Jaidev Goudar, David S Rosen, Guozhi Wang, Qun Zhang, Russell Patera filed Critical Fmc Corp
Priority to EP05798202A priority Critical patent/EP1794144A2/en
Priority to BRPI0515275-5A priority patent/BRPI0515275A/en
Priority to JP2007531438A priority patent/JP2008512495A/en
Publication of WO2006031764A2 publication Critical patent/WO2006031764A2/en
Publication of WO2006031764A3 publication Critical patent/WO2006031764A3/en
Priority to IL181102A priority patent/IL181102A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Improved processes are described for preparing compounds of formulae: (B, C, F, H) wherein R1, R2, B and Z are defined herein. These compounds are useful in the preparation of N-(substituted arylmethyl)-4­(disubstituted methyl)piperidines.
PCT/US2005/032473 2004-09-13 2005-09-12 Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates WO2006031764A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP05798202A EP1794144A2 (en) 2004-09-13 2005-09-12 Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates
BRPI0515275-5A BRPI0515275A (en) 2004-09-13 2005-09-12 processes for the preparation of n- (substituted arylmethyl) -4- (methyl disubstituted) piperidines and intermediates
JP2007531438A JP2008512495A (en) 2004-09-13 2005-09-12 Process for preparing N- (substituted arylmethyl) -4- (disubstituted methyl) piperidines and intermediates
IL181102A IL181102A0 (en) 2004-09-13 2007-02-01 Processes for preparing n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60953904P 2004-09-13 2004-09-13
US60/609,539 2004-09-13

Publications (2)

Publication Number Publication Date
WO2006031764A2 WO2006031764A2 (en) 2006-03-23
WO2006031764A3 true WO2006031764A3 (en) 2006-07-13

Family

ID=36060625

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/032473 WO2006031764A2 (en) 2004-09-13 2005-09-12 Processes for prepating n-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and intermediates

Country Status (9)

Country Link
EP (1) EP1794144A2 (en)
JP (1) JP2008512495A (en)
KR (1) KR20070052319A (en)
CN (1) CN101018776A (en)
AR (1) AR052977A1 (en)
BR (1) BRPI0515275A (en)
IL (1) IL181102A0 (en)
TW (1) TW200621747A (en)
WO (1) WO2006031764A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1314955A (en) * 1970-11-27 1973-04-26 Richardson Merrell Inc 4-4-alpha-hydroxybenzyl piperidino 4-fluorobutyrophenone derivative
WO2004060371A1 (en) * 2002-12-18 2004-07-22 Fmc Corporation N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1314955A (en) * 1970-11-27 1973-04-26 Richardson Merrell Inc 4-4-alpha-hydroxybenzyl piperidino 4-fluorobutyrophenone derivative
WO2004060371A1 (en) * 2002-12-18 2004-07-22 Fmc Corporation N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHANKLIN J.R. ET AL.: "Synthesis, Calcium-Channel-Blocking Activity, and Antihypertensive Activity of 4-(Diarylmethyl)-1-[3-(aryloxy)propyl]piperidines and Structurally Related Compounds", J. MED. CHEM., vol. 34, May 1991 (1991-05-01), pages 3011 - 3022, XP002241320 *

Also Published As

Publication number Publication date
WO2006031764A2 (en) 2006-03-23
KR20070052319A (en) 2007-05-21
CN101018776A (en) 2007-08-15
BRPI0515275A (en) 2008-07-15
TW200621747A (en) 2006-07-01
IL181102A0 (en) 2007-07-04
EP1794144A2 (en) 2007-06-13
JP2008512495A (en) 2008-04-24
AR052977A1 (en) 2007-04-18

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