WO2006028745A1 - High purity, high molecular weight methoxy-polyethylenglycols (mpeg) - Google Patents
High purity, high molecular weight methoxy-polyethylenglycols (mpeg) Download PDFInfo
- Publication number
- WO2006028745A1 WO2006028745A1 PCT/US2005/030518 US2005030518W WO2006028745A1 WO 2006028745 A1 WO2006028745 A1 WO 2006028745A1 US 2005030518 W US2005030518 W US 2005030518W WO 2006028745 A1 WO2006028745 A1 WO 2006028745A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ethyleneglycol
- process according
- poly
- mpeg
- monomethoxy poly
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
Definitions
- the invention is directed toward novel high molecular weight and high purity mPEG alcohol compositions as well as a process for obtaining said compositions by removing PEG diols from the mPEG alcohol.
- the therapeutic efficacy of bioactive molecules can be improved by conjugating them with poly(ethylene glycol)(PEG).
- the PEG is often a linear poly(ethylene glycol) with one hydroxyl end group capped with a methyl group and the other hydroxyl group activated for conjugation.
- An activated mPEG is made from mPEG alcohol, which in turn is typically made by initiating anionic polymerization of ethylene oxide with methanol or its equivalent. If there is any water in the polymerization, it forms a linear PEG with hydroxyl groups on both ends. Since the PEG diol undergoes the same activation and conjugation chemistry as mPEG alcohol, it's presence in the mPEG alcohol is undesirable.
- U.S. Patent No. 6,455,639 discloses the production of mPEG alcohol by polymerization of EO under very dry conditions with molecular weights up to
- the PEG diol can be converted to its unreactive dimethyl ether. This is performed by initiating polymerization of EO with benzyl alcohol, permethylating all the hydroxyl groups (both on the benzyl PEG and PEG diol), and then removing the benzyl group to give mPEG alcohol and dimethyl PEG (U.S. 6,448,369).
- the permethylation of the PEG diol requires two additional chemistry steps, and the concentration of the desired mPEG alcohol is reduced by the presence of the dimethyl PEG.
- purification techniques for removal of excess diol have been described in the literature.
- the invention is directed toward novel high molecular weight and high purity mPEG alcohol compositions as well as a process for obtaining said compositions by using separation techniques to remove PEG diols from the mPEG.
- the invention comprises a monomethoxy poly(ethyleneglycol) of at least 95% chemical purity by weight, having a polydispersity value of less than 1.1 and having a defined molecular weight of from 10,000 Daltons to about 60,000 Daltons.
- the monomethoxy poly(ethyleneglycol) of the invention has a polydispersity value of less than 1.05.
- the invention further comprises a process for obtaining a monomethoxy poly(ethyleneglycol) of at least 95% chemical purity by weight, having a polydispersity value of less than 1.1 and having a defined molecular weight of at least 10,000 Daltons and up to around 60,000 Daltons.
- the process comprises a first step of providing an impure monomethoxy poly(ethyleneglycol) characterized as a monomethoxy poly(ethyleneglycol) having one or more impurities including poly(ethyleneglycol) [hereinfter “PEG diol”] and low molecular weight organic and inorganic molecules.
- the impure monomethoxy poly(ethyleneglycol) can be obtained according to well-known polymerization techniques as described in "Poly(Ethylene Oxide)" (F .E. Bailey, Jr. and J.V. Koleske, Academic Press, New York, 1976).
- the impure monomethoxy poly(ethyleneglycol) is directly purified by means of one or more separation techniques such as, but not limited to, polymeric adsorption/desorption, ultrafiltration, chromatography, precipitation or combinations of one or more of the above.
- the separated PEG diol and low molecular weight organic or inorganic molecules are then removed from the purified monomethoxy poly(ethyleneglycol).
- the PEG diol may be either of higher or of lower molecular weight than the purified monomethoxy poly(ethyleneglycol) thereby obtained.
- the separation technique comprises polymeric adsorption/desorption.
- the polymeric adsorption/desorption preferably comprises treatment of the impure mPEG alcohol with a polymer containing repeating pendant functional groups capable of hydrogen bonding with the ether oxygen atoms of mPEG alcohol and/or PEG diol, in the presence of a protic solvent.
- the pendant functional groups are selected from the group consisting of CO 2 H, SO 3 H, PO 3 H 2 , NH, NH 2 , OH and SH.
- the polymer is a polyacid. More preferably, the polymer is a poly(carboxylic acid). Most preferably, the polymer is a crosslinked poly(carboxylic acid) resin.
- the protic solvent is selected from the group comprising water, a C 1-3 alcohol or a mixture thereof. More preferably, the protic solvent is water.
- the separation technique comprises ultrafiltration.
- Ultrafiltration comprises contacting an impure mPEG alcohol solution with a membrane of the appropriate pore size as to allow materials of lower molecular weight to pass through the membrane and be removed.
- the separation technique of chromatography comprises placing the polymer on one end of a column packed with an active support, passing a suitable solvent through the column, and collecting fractions at the other end of the column. The various components of the impure alcohol are separated on the column and collected in separate fractions. Analysis of the mPEG polymer for PEG diol content is determined by critical condition HPLC analysis (Gorshkov; J. Chrom. 523, 91 (1990); Kazanskii et al, Polymer Science Ser.
- Critical condition chromatography is useful in this application for analytical separation of the mPEG from PEG diol as the retention time of the polymer is independent of molecular weight, and is only a function of polymer end groups.
- the mPEG and PEG diol polymers are derivatized with 3,5-dinitrobenzoyl chloride and separated at the critical point on a reversed phase analytical column with UV detection.
- the separation technique of precipitation comprises the successive precipitation of polymer from a solution by addition of a miscible nonsolvent, by controlled cooling, or by controlled evaporation of solvent.
- the process further includes the step of isolating the pure monomethoxy poly(ethyleneglycol) composition from aqueous solution by an isolation technique selected from the group consisting of spray drying, addition of a non-solvent, extraction into a good solvent followed by addition of a non- solvent and evaporation of solvent under vacuum.
- an isolation technique selected from the group consisting of spray drying, addition of a non-solvent, extraction into a good solvent followed by addition of a non- solvent and evaporation of solvent under vacuum.
- the more preferred isolation technique comprises spray drying.
- the step of spray drying comprises spraying a solution of polymer into a chamber to form droplets, the solvent of which is evaporated in a flow of hot air to give a dry powder.
- a 3.8 kg sample of crude mPEG (Mp 31,491, 5.0 mol% diol) was dissolved in about 75 kg of DI water and loaded to the ultrafiltration feed tank.
- An Osmonics 2.5 m 1OK MWCO membrane (model # PW2540F1080) was installed.
- the recirculation pump was turned on at 28% output.
- the retentate and permeate back pressure valves were adjusted to achieve a retentate flowrate of 15 lpm with a 30 psi transmembrane pressure.
- the tank volume was initially concentrated down to about 40 liters, at which time DI water was continuously added in order to maintain a constant tank volume.
- a total of 303 kg of permeate was collected at an average rate of about 0.4 lpm.
- GPC analysis of a composite sample indicated the permeate contained 0.7 kg of mPEG.
- the GPC profile of the permeate was noticeably skewed to the lower molecular weight material.
- the retentate fraction in the feed tank was further concentrated to about 33 liters and then drained through a 0.2 micron polypropylene polish filter.
- the final 32.9 kg retentate sample contained 7.6% mPEG by GPC (2.5 kg mPEG). DI water was loaded to the feed tank and recirculated for about 15 minutes to rinse the membrane and piping.
- GPC analysis indicated the 36.3 kg rinse sample contained an additional 0.6 kg of mPEG.
- the mPEG in the final retentate sample was isolated using a spray dryer. The diol concentration in the final isolated product was 2.7 mol%.
- the filtrate was added back to the reactor along with 91g of fresh PAA (enough to complex greater than 75% of the mPEG).
- the reaction mixture was stirred at 61oC for 32 hours.
- the PAA resin containing the mPEG was collected by filtration and the filtrate (7872g) was discarded.
- 115g of the PAA resin wetcake (containing mPEG) were washed with deionized water and added back to the reactor along with 237g of 30% aqueous tetrahydrofuran (THF).
- THF aqueous tetrahydrofuran
- a Buchi B-191 Mini Spray dryer was set up with the following operating parameters: nitrogen flow was 700 L/h, inlet temperature was 95 "C 5 vacuum aspirator was 50% of the maximum speed, and DI water was fed at 15% of the maximum rate. After the system was equilibrated for 30 minutes, the outlet temperature was 36 0 C. A 951-g aqueous solution containing 3.0 wt% of mPEG (28.5 g) was loaded at 15% of the maximum rate. Over the course of the 3 hour and 10 minute addition, the inlet temperature was adjusted to 97, then 99 °C. The outlet temperature ranged from 36 to 38 °C. A total of 9.5 g of mPEG was collected as a fluffy white powder from the cyclone. The mPEG contained 0.31 wt% water by Karl Fisher titration. Example 4 - PAA, Ultrafiltration, and Spray Drying.
- a sample of mPEG (Mp 28164, 3.6 mol% PEG diol) was treated with PAA as described above to provide 15.2-kg of anaqueous solution containing 92.7 g of polymer.
- the solution was subjected to ultrafiltration using an Osmonics 1OK MWCO polyethersulfone membrane as described above to provide a 3.2-kg aqueous solution containing 67.7 g of polymer.
- a portion of the aqueous solution was spray dried as described above to provide 9.1 g of mPEG polymer (Mp 29178) containing 1.3 mol% of PEG diol.
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Polyethers (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05792760A EP1789473A1 (en) | 2004-09-01 | 2005-08-25 | High purity, high molecular weight methoxy-polyethylenglycols (mpeg) |
CN2005800346808A CN101068850B (en) | 2004-09-01 | 2005-08-25 | High purity, high molecular weight methoxy-polyethyleneglycols (MPEG) |
JP2007530186A JP2008511729A (en) | 2004-09-01 | 2005-08-25 | High purity high molecular weight methoxypolyethylene glycol (MPEG) |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/932,629 US20060045866A1 (en) | 2004-09-01 | 2004-09-01 | Novel high purity and high molecular weight mPEG alcohol compositions |
US10/932629 | 2004-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006028745A1 true WO2006028745A1 (en) | 2006-03-16 |
Family
ID=35355094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/030518 WO2006028745A1 (en) | 2004-09-01 | 2005-08-25 | High purity, high molecular weight methoxy-polyethylenglycols (mpeg) |
Country Status (6)
Country | Link |
---|---|
US (2) | US20060045866A1 (en) |
EP (1) | EP1789473A1 (en) |
JP (1) | JP2008511729A (en) |
KR (1) | KR20070058549A (en) |
CN (1) | CN101068850B (en) |
WO (1) | WO2006028745A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009179646A (en) * | 2008-01-29 | 2009-08-13 | Sanyo Chem Ind Ltd | Method for manufacturing polyoxyalkylene ether composition |
WO2010114073A1 (en) | 2009-03-31 | 2010-10-07 | 日油株式会社 | Method for purifying high molecular weight polyoxyalkylene derivative |
WO2010146082A1 (en) * | 2009-06-18 | 2010-12-23 | Basf Se | Method for producing monohydroxypolyalkylene oxides |
EP2476430A1 (en) | 2008-06-13 | 2012-07-18 | Eli Lilly and Company | Pegylated insulin lispro compounds |
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JP5543068B2 (en) * | 2004-12-30 | 2014-07-09 | スリーエム イノベイティブ プロパティズ カンパニー | Chiral fused [1,2] imidazo [4,5-c] cyclic compound |
US8222039B2 (en) * | 2007-02-22 | 2012-07-17 | Biovectra Inc. | Process for purification of water soluble polymers |
KR100922113B1 (en) * | 2007-12-29 | 2009-10-16 | 아이디비켐(주) | A New Preparing Method of Benzyloxypolyethyleneglycol and its derivatives |
JP5569787B2 (en) * | 2009-03-31 | 2014-08-13 | 日油株式会社 | Purification method of high molecular weight polyethylene glycol compound |
JP2013530271A (en) | 2010-05-21 | 2013-07-25 | ゼフィロス インコーポレイテッド | Structural material application method |
GB201207481D0 (en) | 2012-04-26 | 2012-06-13 | Zephyros Inc | Applying flowable materials to synthetic substrates |
CN107321128B (en) * | 2017-05-31 | 2020-11-03 | 南京威尔药业集团股份有限公司 | Reaction system for producing high-purity monomethoxy polyethylene glycol |
US10988489B2 (en) * | 2018-11-27 | 2021-04-27 | Clark Atlanta University | Organoboranes useful as electrolytes for lithium batteries |
CN112724396A (en) * | 2020-12-28 | 2021-04-30 | 苏州欣影生物医药技术有限公司 | Purification method for improving molecular weight distribution of polyethylene glycol derivatives |
CN114636773B (en) * | 2022-05-23 | 2022-08-23 | 广东国标医药科技有限公司 | Method for measuring content of polyethylene glycol monomethyl ether 2000 in pharmaceutic adjuvant |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0824126A1 (en) * | 1995-05-15 | 1998-02-18 | Enzon, Inc. | Preparation of carboxylic acid-containing polyether and biologically active substances derived thereof |
EP0985697A1 (en) * | 1998-03-24 | 2000-03-15 | Nof Corporation | Oxirane derivatives and process for producing the same |
WO2002059179A2 (en) * | 2000-12-18 | 2002-08-01 | Shearwater Corporation | Synthesis of high molecular weight non-peptidic polymer derivatives |
WO2005010075A2 (en) * | 2003-07-22 | 2005-02-03 | Nektar Therapeutics Al, Corporation | Method for preparing functionalized polymers from polymer alcohols |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2983763A (en) * | 1956-04-12 | 1961-05-09 | Jefferson Chem Co Inc | Decolorizing the product of reacting an alkylene oxide with a hydroxylcontaining organic compound in the presence of an alkaline reacting catalyst |
US3974127A (en) * | 1973-09-17 | 1976-08-10 | E. I. Du Pont De Nemours And Company | Alkylene oxide condensates of tetramethylpiperidine alcohols or glycols |
US4911926A (en) * | 1988-11-16 | 1990-03-27 | Mediventures Inc. | Method and composition for reducing postsurgical adhesions |
FR2686088B1 (en) * | 1992-01-10 | 1995-06-23 | Atochem Elf Sa | PROCESS FOR THE MANUFACTURE OF MULTI-SEQUENCE POLYCONDENSATES, IN STAR OR IN NETWORKS BY COUPLING USING DI- OR MULTI-ALDEHYDES, AND POLYCONDENSATES OBTAINED THEREBY. |
FR2689895A1 (en) * | 1992-04-10 | 1993-10-15 | Chryso | Process for the preparation of polyoxyalkyl amines |
US5348569A (en) * | 1993-06-30 | 1994-09-20 | Praxair Technology, Inc. | Modified poly(phenylene oxide) based membranes for enhanced fluid separation |
US5308881A (en) * | 1993-10-25 | 1994-05-03 | The Celotex Corporation | Surfactant for polyisocyanurate foams made with alternative blowing agents |
US5752991A (en) * | 1995-12-29 | 1998-05-19 | Chevron Chemical Company | Very long chain alkylphenyl polyoxyalkylene amines and fuel compositions containing the same |
US6280745B1 (en) * | 1997-12-23 | 2001-08-28 | Alliance Pharmaceutical Corp. | Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions |
US6168719B1 (en) * | 1996-12-27 | 2001-01-02 | Kao Corporation | Method for the purification of ionic polymers |
CA2288992C (en) * | 1997-04-30 | 2012-06-12 | Enzon, Inc. | Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof |
US6642422B2 (en) * | 1998-06-17 | 2003-11-04 | Nof Corporation | Polyoxyalkylene monoalkyl ether, process for producing the same, polymerizable polyoxyalkylene monoalky ether derivative, polymer of said derivative and dispersant comprising said polymer |
-
2004
- 2004-09-01 US US10/932,629 patent/US20060045866A1/en not_active Abandoned
-
2005
- 2005-08-25 KR KR1020077007148A patent/KR20070058549A/en not_active Application Discontinuation
- 2005-08-25 JP JP2007530186A patent/JP2008511729A/en active Pending
- 2005-08-25 EP EP05792760A patent/EP1789473A1/en not_active Withdrawn
- 2005-08-25 CN CN2005800346808A patent/CN101068850B/en not_active Expired - Fee Related
- 2005-08-25 WO PCT/US2005/030518 patent/WO2006028745A1/en active Application Filing
-
2009
- 2009-10-22 US US12/603,708 patent/US20100041160A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0824126A1 (en) * | 1995-05-15 | 1998-02-18 | Enzon, Inc. | Preparation of carboxylic acid-containing polyether and biologically active substances derived thereof |
EP0985697A1 (en) * | 1998-03-24 | 2000-03-15 | Nof Corporation | Oxirane derivatives and process for producing the same |
WO2002059179A2 (en) * | 2000-12-18 | 2002-08-01 | Shearwater Corporation | Synthesis of high molecular weight non-peptidic polymer derivatives |
WO2005010075A2 (en) * | 2003-07-22 | 2005-02-03 | Nektar Therapeutics Al, Corporation | Method for preparing functionalized polymers from polymer alcohols |
Non-Patent Citations (1)
Title |
---|
A. V. GORSHKOV ET AL: "Chromatographic investigations of macromolecules in the "critical range" of liquid chromatography", JOURNAL OF CHROMATOGRAPHY, vol. 523, 1990, Amsterdam, pages 91 - 102, XP002355585 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009179646A (en) * | 2008-01-29 | 2009-08-13 | Sanyo Chem Ind Ltd | Method for manufacturing polyoxyalkylene ether composition |
EP2476430A1 (en) | 2008-06-13 | 2012-07-18 | Eli Lilly and Company | Pegylated insulin lispro compounds |
WO2010114073A1 (en) | 2009-03-31 | 2010-10-07 | 日油株式会社 | Method for purifying high molecular weight polyoxyalkylene derivative |
US8097692B2 (en) | 2009-03-31 | 2012-01-17 | Nof Corporation | Purification method of high-molecular-weight polyoxyalkylene derivative |
WO2010146082A1 (en) * | 2009-06-18 | 2010-12-23 | Basf Se | Method for producing monohydroxypolyalkylene oxides |
EP2275470A1 (en) * | 2009-06-18 | 2011-01-19 | Basf Se | Method for manufacturing monohydroxypolyalkylene oxides |
US9920164B2 (en) | 2009-06-18 | 2018-03-20 | Basf Se | Method for producing monohydroxypolyalkylene oxides |
Also Published As
Publication number | Publication date |
---|---|
KR20070058549A (en) | 2007-06-08 |
US20100041160A1 (en) | 2010-02-18 |
US20060045866A1 (en) | 2006-03-02 |
JP2008511729A (en) | 2008-04-17 |
EP1789473A1 (en) | 2007-05-30 |
CN101068850B (en) | 2011-09-28 |
CN101068850A (en) | 2007-11-07 |
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