WO2006024414A3 - Verfahren zur herstellung einer ingwer-fraktion und deren verwendung zur inhibierung humaner cyp enzyme - Google Patents

Verfahren zur herstellung einer ingwer-fraktion und deren verwendung zur inhibierung humaner cyp enzyme Download PDF

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Publication number
WO2006024414A3
WO2006024414A3 PCT/EP2005/009020 EP2005009020W WO2006024414A3 WO 2006024414 A3 WO2006024414 A3 WO 2006024414A3 EP 2005009020 W EP2005009020 W EP 2005009020W WO 2006024414 A3 WO2006024414 A3 WO 2006024414A3
Authority
WO
WIPO (PCT)
Prior art keywords
producing
inhibiting human
cyp enzymes
fraction
human cyp
Prior art date
Application number
PCT/EP2005/009020
Other languages
English (en)
French (fr)
Other versions
WO2006024414A2 (de
Inventor
Thomas Ebner
Eva Ludwig-Schwellinger
Stefan Matthias Blech
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Pharma
Thomas Ebner
Eva Ludwig-Schwellinger
Stefan Matthias Blech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Pharma, Thomas Ebner, Eva Ludwig-Schwellinger, Stefan Matthias Blech filed Critical Boehringer Ingelheim Int
Priority to CA002575797A priority Critical patent/CA2575797A1/en
Priority to EP05776543A priority patent/EP1786447A2/de
Priority to JP2007528710A priority patent/JP2008511566A/ja
Publication of WO2006024414A2 publication Critical patent/WO2006024414A2/de
Publication of WO2006024414A3 publication Critical patent/WO2006024414A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung einer Ingwer-Fraktion, die mittels dieses Verfahrens hergestellte Fraktion sowie deren Verwendung allein oder in Kombination mit Arzneimitteln zur Inhibierung humaner Cytochrom P450 (CYP) Enzyme (insbesondere Cytochrom P450 3A4, CYP3A4) zur positiven Beeinflussung der oralen Bioverfügbarkeit und Pharmakokinetik von Wirkstoffen.
PCT/EP2005/009020 2004-08-28 2005-08-20 Verfahren zur herstellung einer ingwer-fraktion und deren verwendung zur inhibierung humaner cyp enzyme WO2006024414A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002575797A CA2575797A1 (en) 2004-08-28 2005-08-20 Method for producing a ginger fraction and the use thereof for inhibiting human cyp enzymes
EP05776543A EP1786447A2 (de) 2004-08-28 2005-08-20 Verfahren zur herstellung einer ingwer-fraktion und deren verwendung zur inhibierung humaner cyp enzyme
JP2007528710A JP2008511566A (ja) 2004-08-28 2005-08-20 ショウガ画分の調製方法およびヒトｃｙｐ酵素を阻害するためのその使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004041716A DE102004041716A1 (de) 2004-08-28 2004-08-28 Verfahren zur Herstellung einer Ingwer-Fraktion und deren Verwendung zur Inhibierung humaner CYP Enzyme
DE102004041716.4 2004-08-28

Publications (2)

Publication Number Publication Date
WO2006024414A2 WO2006024414A2 (de) 2006-03-09
WO2006024414A3 true WO2006024414A3 (de) 2006-06-15

Family

ID=35106705

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/009020 WO2006024414A2 (de) 2004-08-28 2005-08-20 Verfahren zur herstellung einer ingwer-fraktion und deren verwendung zur inhibierung humaner cyp enzyme

Country Status (6)

Country Link
US (1) US20060051437A1 (de)
EP (1) EP1786447A2 (de)
JP (1) JP2008511566A (de)
CA (1) CA2575797A1 (de)
DE (1) DE102004041716A1 (de)
WO (1) WO2006024414A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005062144A1 (de) * 2005-12-22 2007-08-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ingwerfraktion zur Inhibierung humaner CYP Enzyme
DE102005062145A1 (de) * 2005-12-22 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ingwerextrakt zur Inhibierung humaner Arzneistofftransporter
CN100429517C (zh) * 2006-09-29 2008-10-29 暨南大学 筛选中药抗血小板聚集作用活性成分的细胞膜固相色谱法模型的建立方法
JP5103296B2 (ja) * 2008-06-23 2012-12-19 花王株式会社 ジンジャーオレオレジン精製物の製造方法
KR101235811B1 (ko) * 2011-08-11 2013-02-21 한국기초과학지원연구원 Ｃｙｐ４ａ 저해제를 유효성분으로 함유하는 당뇨병의 치료 또는 예방용 약학적 조성물
JP5808772B2 (ja) * 2013-05-13 2015-11-10 株式会社エヌ・エル・エー 肝細胞内のミトコンドリアの活性化方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003045411A2 (de) * 2001-11-26 2003-06-05 Finzelberg Gmbh & Co. Kg Ingwer-extraktzubereitung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2224227A1 (en) * 1995-06-07 1996-12-19 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
US5665386A (en) * 1995-06-07 1997-09-09 Avmax, Inc. Use of essential oils to increase bioavailability of oral pharmaceutical compounds
JP4759182B2 (ja) * 2001-08-03 2011-08-31 花王株式会社 水溶性ショウキョウエキス

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003045411A2 (de) * 2001-11-26 2003-06-05 Finzelberg Gmbh & Co. Kg Ingwer-extraktzubereitung

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GOPALAM A ET AL: "ESSENTIAL OILS OF GINGER", 1989, INDIAN PERFUMER, VOL. 33, NR. 1, PAGE(S) 63-69, ISSN: 0019-607X, XP009063900 *
GOVINDARAJAN B ET AL: "EVALUATION OF SPICES AND OLEORESINS - VII - IMPROVED SEPARATION AND ESTIMATION OF PUNGENT AND RELATED COMPONENTS OF GINGER BY THIN-LAYER CHROMATOGRAPHY", JOURNAL OF FOOD QUALITY, FOOD AND NUTRITION PRESS, TRUMBULL, CT, US, vol. 2, no. 3, 1979, pages 205 - 217, XP009056090, ISSN: 0146-9428 *
KAWAKISHI S ET AL: "CHEMISTRY OF GINGER COMPONENTS AND INHIBITORY FACTORS OF THE ARACHIDONIC ACID CASCADE", ACS SYMPOSIUM SERIES, WASHINGTON, DC, US, vol. 547, 1994, pages 244 - 250, XP009056089, ISSN: 0097-6156 *
SALZER U -J: "Analytical evaluation of seasoning extracts (oleoresins) and essential oils from seasonings. II.", 1975, INTERNATIONAL FLAVOURS AND FOOD ADDITIVES 1975 HAARMANN & REIMER GMBH, D-345 HOLZMINDEN, FEDERAL REPUBLIC OF GERMANY, VOL. 6, NR. 4, PAGE(S) 206, XP009056048 *

Also Published As

Publication number Publication date
DE102004041716A1 (de) 2006-03-09
WO2006024414A2 (de) 2006-03-09
EP1786447A2 (de) 2007-05-23
JP2008511566A (ja) 2008-04-17
US20060051437A1 (en) 2006-03-09
CA2575797A1 (en) 2006-03-09

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