WO2006023576A3 - Etablissement de profils pharmacologiques de medicaments avec des dosages a base de cellules - Google Patents

Etablissement de profils pharmacologiques de medicaments avec des dosages a base de cellules Download PDF

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Publication number
WO2006023576A3
WO2006023576A3 PCT/US2005/029278 US2005029278W WO2006023576A3 WO 2006023576 A3 WO2006023576 A3 WO 2006023576A3 US 2005029278 W US2005029278 W US 2005029278W WO 2006023576 A3 WO2006023576 A3 WO 2006023576A3
Authority
WO
WIPO (PCT)
Prior art keywords
drugs
amount
protein
profile
cell
Prior art date
Application number
PCT/US2005/029278
Other languages
English (en)
Other versions
WO2006023576A2 (fr
Inventor
Marnie L Macdonald
John K Westwick
Helen Yu
Original Assignee
Odyssey Thera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US60231704P priority Critical
Priority to US60/602,317 priority
Priority to US11/205,021 priority patent/US20060040338A1/en
Application filed by Odyssey Thera Inc filed Critical Odyssey Thera Inc
Publication of WO2006023576A2 publication Critical patent/WO2006023576A2/fr
Publication of WO2006023576A3 publication Critical patent/WO2006023576A3/fr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5035Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5097Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving plant cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00Post-translational modifications [PTMs] in chemical analysis of biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/10Post-translational modifications [PTMs] in chemical analysis of biological material acylation, e.g. acetylation, formylation, lipoylation, myristoylation, palmitoylation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/12Post-translational modifications [PTMs] in chemical analysis of biological material alkylation, e.g. methylation, (iso-)prenylation, farnesylation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/36Post-translational modifications [PTMs] in chemical analysis of biological material addition of addition of other proteins or peptides, e.g. SUMOylation, ubiquitination
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/38Post-translational modifications [PTMs] in chemical analysis of biological material addition of carbohydrates, e.g. glycosylation, glycation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells

Abstract

La présente invention concerne une technique permettant d'établir des profils d'innocuité de composés chimiques ainsi que d'établir des profils pharmacologiques. Cette technique consiste (A) à tester les effets de ces composés chimiques sur la quantité et/ou des modifications post-translationnelles d'au moins deux macromolécules dans des cellules intactes, (B) à construire un profil pharmacologique fondé sur les résultats de ces tests et, (C) à comparer ce profil au(x) profil(s) des médicaments dont les caractéristiques d'innocuité sont établies. Par ailleurs, cette invention concerne aussi une composition comprenant un panneau de dosage, ce panneau comprenant au moins un dosage de grande densité de la quantité et/ou de la modification post-translationnelle d'une protéine et au moins un dosage de grande densité de la quantité et/ou de la localisation subcellulaire d'une interaction protéine-protéine.
PCT/US2005/029278 2004-08-18 2005-08-18 Etablissement de profils pharmacologiques de medicaments avec des dosages a base de cellules WO2006023576A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US60231704P true 2004-08-18 2004-08-18
US60/602,317 2004-08-18
US11/205,021 US20060040338A1 (en) 2004-08-18 2005-08-17 Pharmacological profiling of drugs with cell-based assays

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AU2005277446A AU2005277446A1 (en) 2004-08-18 2005-08-18 Pharmacological profiling of drugs with cell-based assays
EP05788134A EP1784642A4 (fr) 2004-08-18 2005-08-18 Etablissement de profils pharmacologiques de medicaments avec des dosages a base de cellules
CA 2577152 CA2577152A1 (fr) 2004-08-18 2005-08-18 Etablissement de profils pharmacologiques de medicaments avec des dosages a base de cellules
JP2007527980A JP2008510963A (ja) 2004-08-18 2005-08-18 細胞ベースアッセイを用いた薬物の薬理学的プロファイリング

Publications (2)

Publication Number Publication Date
WO2006023576A2 WO2006023576A2 (fr) 2006-03-02
WO2006023576A3 true WO2006023576A3 (fr) 2006-07-06

Family

ID=35910070

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029278 WO2006023576A2 (fr) 2004-08-18 2005-08-18 Etablissement de profils pharmacologiques de medicaments avec des dosages a base de cellules

Country Status (6)

Country Link
US (1) US20060040338A1 (fr)
EP (3) EP2341345A1 (fr)
JP (2) JP2008510963A (fr)
AU (1) AU2005277446A1 (fr)
CA (1) CA2577152A1 (fr)
WO (1) WO2006023576A2 (fr)

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US7695926B2 (en) 2001-07-10 2010-04-13 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting receptor-ligand interactions in single cells
US7381535B2 (en) * 2002-07-10 2008-06-03 The Board Of Trustees Of The Leland Stanford Junior Methods and compositions for detecting receptor-ligand interactions in single cells
US7393656B2 (en) * 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
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US20060160109A1 (en) * 2004-11-22 2006-07-20 Odyssey Thera, Inc. Harnessing network biology to improve drug discovery
EP1842147A2 (fr) * 2005-01-24 2007-10-10 The Board of Trustees of The Leland Stanford Junior University Utilisation de reseaux de bayes afin de modeliser des systemes de signalisation des cellules
US9862770B2 (en) * 2005-10-19 2018-01-09 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
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WO2009134944A2 (fr) * 2008-04-29 2009-11-05 Nodality, Inc. Procédés de détermination de l'état de santé d'un individu
US20090291458A1 (en) * 2008-05-22 2009-11-26 Nodality, Inc. Method for Determining the Status of an Individual
US8399206B2 (en) 2008-07-10 2013-03-19 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
US8227202B2 (en) * 2008-07-10 2012-07-24 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
WO2010045651A1 (fr) * 2008-10-17 2010-04-22 Nodality, Inc. Procédés d’analyse de réponse à un médicament
AU2012229102B2 (en) 2011-03-17 2016-02-04 Cernostics, Inc. Systems and compositions for diagnosing Barrett's esophagus and methods of using the same
US8937213B2 (en) 2011-05-21 2015-01-20 Christopher E. Hopkins Transgenic biosensors

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Also Published As

Publication number Publication date
JP2014016337A (ja) 2014-01-30
JP2008510963A (ja) 2008-04-10
EP1784642A4 (fr) 2008-10-22
EP2363496A1 (fr) 2011-09-07
EP2341345A1 (fr) 2011-07-06
CA2577152A1 (fr) 2006-03-02
WO2006023576A2 (fr) 2006-03-02
US20060040338A1 (en) 2006-02-23
EP1784642A2 (fr) 2007-05-16
AU2005277446A1 (en) 2006-03-02

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