WO2006012642A3 - Pyrrole derivatives as pharmaceutical agents - Google Patents

Pyrrole derivatives as pharmaceutical agents Download PDF

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Publication number
WO2006012642A3
WO2006012642A3 PCT/US2005/026916 US2005026916W WO2006012642A3 WO 2006012642 A3 WO2006012642 A3 WO 2006012642A3 US 2005026916 W US2005026916 W US 2005026916W WO 2006012642 A3 WO2006012642 A3 WO 2006012642A3
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WO
WIPO (PCT)
Prior art keywords
pharmaceutical agents
pyrrole derivatives
receptors
activity
modulating
Prior art date
Application number
PCT/US2005/026916
Other languages
French (fr)
Other versions
WO2006012642A2 (en
Inventor
Bannen Lynne Canne
Jeff Chen
Lisa Esther Dalrymple
Brenton T Flatt
Timothy Patrick Forsyth
Xiao-Hu Gu
Morrison B Mac
Larry W Mann
Grace Mann
Richard Martin
Raju Mohan
Brett Murphy
Michael Charles Nyman
William C Stevens Jr
Tie-Lin Wang
Yong Wang
Jason H Wu
Original Assignee
Exelixis Inc
Bannen Lynne Canne
Jeff Chen
Lisa Esther Dalrymple
Brenton T Flatt
Timothy Patrick Forsyth
Xiao-Hu Gu
Morrison B Mac
Larry W Mann
Grace Mann
Richard Martin
Raju Mohan
Brett Murphy
Michael Charles Nyman
William C Stevens Jr
Tie-Lin Wang
Yong Wang
Jason H Wu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US59243904P priority Critical
Priority to US59246904P priority
Priority to US60/592,439 priority
Priority to US60/592,469 priority
Application filed by Exelixis Inc, Bannen Lynne Canne, Jeff Chen, Lisa Esther Dalrymple, Brenton T Flatt, Timothy Patrick Forsyth, Xiao-Hu Gu, Morrison B Mac, Larry W Mann, Grace Mann, Richard Martin, Raju Mohan, Brett Murphy, Michael Charles Nyman, William C Stevens Jr, Tie-Lin Wang, Yong Wang, Jason H Wu filed Critical Exelixis Inc
Priority claimed from CN200580026842.3A external-priority patent/CN101006052B/en
Publication of WO2006012642A2 publication Critical patent/WO2006012642A2/en
Publication of WO2006012642A3 publication Critical patent/WO2006012642A3/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • C07D207/402,5-Pyrrolidine-diones
    • C07D207/4162,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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Abstract

Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
PCT/US2005/026916 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents WO2006012642A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US59243904P true 2004-07-30 2004-07-30
US59246904P true 2004-07-30 2004-07-30
US60/592,439 2004-07-30
US60/592,469 2004-07-30

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
DK05803281.4T DK1773768T3 (en) 2004-07-30 2005-07-30 PYRROLD DERIVATIVES AS PHARMACEUTICAL AGENTS
CA2573426A CA2573426C (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
KR1020077004302A KR101155288B1 (en) 2004-07-30 2005-07-30 Pyrrole Derivatives as Pharmaceutical Agents
ES05803281T ES2697524T3 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
JP2007523832A JP4703649B2 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
RU2007107388/04A RU2470916C2 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as medicinal substances
CN200580026842.3A CN101006052B (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
NZ552632A NZ552632A (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
BRPI0513677A BRPI0513677B8 (en) 2004-07-30 2005-07-30 pyrrole derivatives as pharmaceutical agents
LTEP05803281.4T LT1773768T (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
EP05803281.4A EP1773768B8 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
AU2005266890A AU2005266890C1 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
US11/572,962 US8026237B2 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
PL05803281T PL1773768T3 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
SI200532237T SI1773768T1 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
IL180630A IL180630A (en) 2004-07-30 2007-01-10 Pyrrole derivatives as pharmaceutical agents
NO20070910A NO344324B1 (en) 2004-07-30 2007-02-16 Pyrrole derivatives as pharmaceuticals
US13/214,665 US8367667B2 (en) 2004-07-30 2011-08-22 Pyrrole derivatives as pharmaceutical agents
CY181101235T CY1120922T1 (en) 2004-07-30 2018-11-21 PYRROL PRODUCTS AS PHARMACEUTICAL AGENTS

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/572,962 A-371-Of-International US8026237B2 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents
US13/214,665 Division US8367667B2 (en) 2004-07-30 2011-08-22 Pyrrole derivatives as pharmaceutical agents

Publications (2)

Publication Number Publication Date
WO2006012642A2 WO2006012642A2 (en) 2006-02-02
WO2006012642A3 true WO2006012642A3 (en) 2006-07-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/026916 WO2006012642A2 (en) 2004-07-30 2005-07-30 Pyrrole derivatives as pharmaceutical agents

Country Status (21)

Country Link
US (2) US8026237B2 (en)
EP (1) EP1773768B8 (en)
JP (2) JP4703649B2 (en)
KR (1) KR101155288B1 (en)
AU (1) AU2005266890C1 (en)
BR (1) BRPI0513677B8 (en)
CA (1) CA2573426C (en)
CY (1) CY1120922T1 (en)
DK (1) DK1773768T3 (en)
ES (1) ES2697524T3 (en)
HU (1) HUE041596T2 (en)
IL (1) IL180630A (en)
LT (1) LT1773768T (en)
NO (1) NO344324B1 (en)
NZ (1) NZ552632A (en)
PL (1) PL1773768T3 (en)
PT (1) PT1773768T (en)
RU (1) RU2470916C2 (en)
SG (1) SG155188A1 (en)
SI (1) SI1773768T1 (en)
WO (1) WO2006012642A2 (en)

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HUE027546T2 (en) 2003-08-29 2016-10-28 The Brigham And Women's Hospital Inc Hydantoin derivatives as inhibitors of cellular necrosis
SE0302573D0 (en) 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
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