WO2006012237A3 - Aripiprazole crystaline forms and associated methods - Google Patents

Aripiprazole crystaline forms and associated methods Download PDF

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Publication number
WO2006012237A3
WO2006012237A3 PCT/US2005/022327 US2005022327W WO2006012237A3 WO 2006012237 A3 WO2006012237 A3 WO 2006012237A3 US 2005022327 W US2005022327 W US 2005022327W WO 2006012237 A3 WO2006012237 A3 WO 2006012237A3
Authority
WO
WIPO (PCT)
Prior art keywords
aripiprazole
associated methods
crystaline
forms
crystaline forms
Prior art date
Application number
PCT/US2005/022327
Other languages
French (fr)
Other versions
WO2006012237A2 (en
Inventor
Qingwen Zhang
Yan-Yan Xu
Huilin Shi
Xia Yin
Xiaojin Xi
Dianguo Su
Original Assignee
Shanghai Inst Pharm Industry
Watson Lab Inc
Qingwen Zhang
Yan-Yan Xu
Huilin Shi
Xia Yin
Xiaojin Xi
Dianguo Su
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Inst Pharm Industry, Watson Lab Inc, Qingwen Zhang, Yan-Yan Xu, Huilin Shi, Xia Yin, Xiaojin Xi, Dianguo Su filed Critical Shanghai Inst Pharm Industry
Publication of WO2006012237A2 publication Critical patent/WO2006012237A2/en
Publication of WO2006012237A3 publication Critical patent/WO2006012237A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4

Abstract

A crystal form of anhydrous aripiprazole having good stability, which can be prepared by simple and economical processes, including such processes are disclosed and described. In one aspect, such a process may include dissolving aripiprazole in an appropriate solvent by heating, and then rapidly cooling with agitation of high speed, to cause the anhydrous aripiprazole of crystal a to swiftly and uniformly precipitate.
PCT/US2005/022327 2004-06-25 2005-06-24 Aripiprazole crystaline forms and associated methods WO2006012237A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58330304P 2004-06-25 2004-06-25
US60/583,303 2004-06-25
US16646505A 2005-06-23 2005-06-23
US11/166,465 2005-06-23

Publications (2)

Publication Number Publication Date
WO2006012237A2 WO2006012237A2 (en) 2006-02-02
WO2006012237A3 true WO2006012237A3 (en) 2006-12-21

Family

ID=35786664

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/022327 WO2006012237A2 (en) 2004-06-25 2005-06-24 Aripiprazole crystaline forms and associated methods

Country Status (1)

Country Link
WO (1) WO2006012237A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2374922T3 (en) 2003-12-16 2012-02-23 Teva Pharmaceutical Industries Ltd. ARIPIPRAZOL CRYSTAL FORMS PREPARATION PROCEDURES.
US7714129B2 (en) 2003-12-16 2010-05-11 Teva Pharmaceutical Industries Ltd. Methods of preparing anhydrous aripiprazole form II
WO2007004061A1 (en) * 2005-04-15 2007-01-11 Medichem, S.A. Syntheses and preparations of polymorphs of crystalline aripiprazole
WO2008020453A2 (en) * 2006-08-17 2008-02-21 Unichem Laboratories Limited A process for the preparation of a novel crystalline polymorph of aripiprazole
GB0618879D0 (en) 2006-09-26 2006-11-01 Zysis Ltd Pharmaceutical compositions
WO2008059518A2 (en) * 2006-09-28 2008-05-22 Cadila Healthcare Limited Process for preparing crystalline aripiprazole
WO2008051541A2 (en) 2006-10-24 2008-05-02 Cambrex Charles City, Inc. Process for preparing anhydrous aripirazole type i
EP2238976B1 (en) 2009-04-03 2012-06-27 Hexal AG Oral films comprising 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro- 1H-quinolin-2-one base or salts or hydrates thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Also Published As

Publication number Publication date
WO2006012237A2 (en) 2006-02-02

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