WO2006009694A2 - Crystal of egfr extracellular domain and cetuximab fab fragment and uses thereof - Google Patents

Abstract

The present invention relates to co-crystals of cetuximab Fab in a complex with extracellular domain of EGFR, and structure coordinates obtained from such crystal. Such coordinates are useful for identifying mimetics that bind to the extracellular domain of EGFR. Such mimetics may for example inhibit binding of ligand to EGFR, inhibit activation of EGFR, and/or reduce proliferation of tumor cells.

Description

CRYSTAL OF EGFR EXTRACELLULAR DOMAIN AND CETUXIMAB FAB FRAGMENT AND USES THEREOF

Field of the Invention

[0001] The present invention relates to co-crystals of cetuximab Fab in a complex with extracellular domain of EGFR, and structure coordinates obtained from such crystal. Such coordinates are useful for identifying mimetics, preferably EGFR antagonists, that bind to the extracellular domain of EGFR. Such mimetics may for example inhibit binding of ligand to EGFR, inhibit activation of EGFR, and/or reduce proliferation of tumor cells.

Background of the Invention

[0002] Although normal cells proliferate by the highly controlled activation of growth factor receptor tyrosine kinases ("RTKs") by their respective ligands, cancer cells also proliferate by the activation of growth factor receptors, but lose the careful control of normal proliferation. The loss of control may be caused by numerous factors, such as the overexpression of growth factors and/or receptors, and autonomous activation of biochemical pathways regulated by growth factors. Some examples of RTKs involved in tumorigenesis are the receptors for epidermal growth factor receptor (EGFR) (also known as human EGF receptor- 1 (HERl)), platelet-derived growth factor (PDGFR), insulin-like growth factor (IGFR), nerve growth factor (NGFR), and fibroblast growth factor (FGF). Binding of growth factors to these cell surface receptors induces receptor activation, which initiates and modifies signal transduction pathways and leads to cell proliferation and differentiation.

[0003] Generally, RTKs have an extracellular region, a transmembrane hydrophobic region, and an intracellular region bearing a kinase domain. The first step in the activation of an RTK is ligand-induced dimerization leading to exposure of phosphorylation sites, activation of the intracellular kinase domain and recruitment of down-stream signaling molecules. The most commonly observed mode of RTK dimerization involves the "crosslinking" of two receptors having exposed dimerization interfaces by binding of a bivalent ligand. For EGFR, structural data published in recent years have led to the proposal of quite a different mechanism. In the absence of ligand, a distinct configuration of the receptor monomer occludes the dimerization interface of the receptor by burying it in an intramolecular "tether." Ligand binding induces a conformational change in EGFR that exposes this dimerization site, promoting dimerization and receptor activation.

[0004] EGFR is a 170 kD membrane-spanning glycoprotein with an extracellular ligand binding domain, a transmembrane region and a cytoplasmic protein tyrosine kinase domain. Examples of ligands that stimulate EGFR include epidermal growth factor (EGF), transforming growth factor-α (TGF-α), heparin-binding growth factor (HBGF), β-cellulin, and Cripto-1. Binding of specific ligands results in EGFR autophosphorylation, activation of the receptor's cytoplasmic tyrosine kinase domain and initiation of multiple signal transduction pathways that regulate tumor growth and survival.

[0005] Growth factors that activate EGFR are also thought to play a role in tumor angiogenesis. Angiogenesis, which refers to the formation of capillaries from pre-existing vessels in the embryo and adult organism, is known to be a key element in tumor growth, survival and metastasis. It has been reported that EGFR mediated stimulation of tumor cells leads to increased expression of the angiogenic factors vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), and basic fibroblast growth factor (bFGF), which can lead to activation of tumor-associated vascular endothelial cells. Stimulation of rumor associated vascular endothelial cells may also occur through activation of their own EGF receptors, by tumor produced growth factors such as TGF-α and EGF.

[0006] It has been reported that many human tumors express or overexpress EGFR. Expression of EGFR is correlated with poor prognosis, decreased survival, and/or increased metastasis. EGFR, because of this involvement in tumorigenesis, has been specifically targeted for anticancer therapies. These therapies have predominantly included either a monoclonal antibody that blocks binding of ligand to the extracellular domain of the receptor or a synthetic tyrosine kinase inhibitor that acts directly on the intracellular region to prevent signal transduction.

[0007] Cetuximab MAb (ERBITUX^®) is a recombinant, human/mouse chimeric, monoclonal antibody composed of the Fv regions of a murine anti-EGFR antibody with human IgGl heavy and kappa light chain constant regions and has an approximate molecular weight of 152 kDa. Cetuximab binds specifically to the extracellular domain of the human EGFR, and is an EGFR antagonist, which blocks ligand binding to EGFR, prevents receptor activation, and inhibits growth of tumor cells that express EGFR. Cetuximab has been approved for use in combination with or without irinotecan in the treatment of patients with epidermal growth factor receptor-expressing, metastatic colorectal cancer who are refractory or can not tolerate irinotecan-based chemotherapy. Cetuximab has been shown to be effective for treatment of psoriasis.

[0008] The crystal structure of an EGF-EGFR extracellular domain complex, wherein the receptor domain exists in dimeric form, has been provided Ogiso, H. et al., 2002, Cell 110, 775-787. The structure of an EGF-EGFR extracellular domain complex obtained by crystallization at low, non-physiological pH, wherein the receptor exists in monomelic form has also been provided Ferguson, K.M. et al., 2003, MoI Cell 11, 507-517. The structure of a transforming growth factor alpha (TGF-α)-EGFR extracellular domain complex in dimeric form has also been determined (Garrett, T.P. et al., 2002, Cell 110, 763-773).

[0009] However, the crystal structure of EGFR with an antagonist, particularly cetuximab Fab, has not been previously determined. The invention disclosed herein provides for the first time crystals and atomic coordinates of a complex of an EGFR extracellular domain and cetuximab Fab. Accordingly, the present invention provides methods for identifying potential mimetics by screening against at least a subset of the coordinates obtained from such a crystal. Mimetics may be assayed for biological activities to obtain EGFR antagonists useful for treatment of EGFR dependent conditions or diseases. EGFR antagonists interact with the receptor to inhibit EGFR tyrosine kinase activity, without limitation, by blocking ligand binding, inhibiting receptor dimerization, ultimately inhibiting receptor substrate phosphorylation, gene activation, and cellular proliferation. Preferably, the antagonists have substantially similar or improved effectiveness as compared to cetuximab. The antagonists are used for treatment of conditions associated with EGFR expression. Such diseases include tumors that express, or overexpress EGFR and which may be stimulated by a ligand of EGFR. Also included are hyperproliferative diseases stimulated by a ligand of EGFR.

Summary of the Invention

[0010] In one aspect, the present invention provides a crystal of a receptor-antibody complex comprising a receptor-antibody complex of an epidermal growth factor receptor (EGFR) extracellular domain and cetuximab Fab, wherein the crystal has a resolution determined by X-ray crystallography of better than about 5.0 Angstroms. Preferably, the crystal has a resolution determined by X-ray crystallography of better than about 4.0 Angstroms, more preferably better than about 3.0 Angstroms. Preferably the crystal belongs to space group P2i and has unit cell dimensions a = 77.8 A, b = 70.9 A, c = 147.1 A, and β = 102.5°. Preferably, the crystal has atomic coordinates provided in Table 2.

[0011] In another aspect, the present invention provides a method for preparing a crystal of a complex of an epidermal growth factor receptor (EGFR) extracellular domain and cetuximab Fab comprising preparing a solution containing the extracellular domain of EGFR and cetuximab Fab fragment, and growing the crystal. Preferably the pH of the solution is about 6.0 to about 8.0.

[0012] In another aspect, the present invention provides a method of identifying a mimetic of cetuximab comprising comparing a three-dimensional structure of the mimetic with a three-dimensional structure determined for the above crystal complex. Preferably, the three dimensional structure of the mimetic is compared with at least a subset of the coordinates provided in Table 2.

[0013] In one embodiment, identifying a mimetic is carried out by comparing the three- dimensional structure of the mimetic against the coordinates of at least one EGFR amino acid bound by cetuximab Fab. Such EGFR amino acid is selected from the group consisting of GIn 384, GIn 408, Ser 418, Ser 440, Lys 465, Ser 468, and Asn 469. In one embodiment, the locations of atoms of the mimetic that contact EGFR correspond to atoms of cetuximab that contact EGFR. In yet another embodiment, screening is carried out by comparing a three dimensional structure of a mimetic with the atomic coordinates of a region of EGFR selected from the group consisting of about amino acid residue 350 to about amino acid residue 354, about amino acid residue 380 to about amino acid residue 385, about amino acid residue 405 to about amino acid residue 420, about amino acid residue 435 to about amino acid residue 475 and combinations thereof.

[0014] The mimetic may be a small molecule, a peptide, or a polypeptide, preferably an antibody or a fragment thereof. [0015] In another aspect of the invention, a mimetic that is an antibody or a fragment thereof is identified by introducing one or more substitutions in at least a single CDR region of cetuximab and/or at non-CDR amino acids of the antibody that interact with the CDR and affect its conformation. In one embodiment, at most a single substitution is made in each CDR. In another embodiment, substitution are made solely in CDR3 or at amino acids that affect the conformation of CDR3.

[0016] In another aspect, the present invention provides the above methods carried out with use of a computer.

[0017] The invention further provides a method for synthesizing the mimetic and assaying its binding or physiological activity to select EGFR antagonists useful for inhibiting EGFR function and treating EGFR-associated diseases or conditions. In an aspect of the invention, a mimetic is provided that inhibits tyrosine kinase activity of the receptor. In another aspect of the invention, the mimetic inhibits dimerization of EGFR expressed by a cell. Preferably, the mimetic blocks binding of EGF to EGFR. Mimetics of the invention bind to EGFR and inhibit EGFR functional activity, preferably to a similar or greater extent than cetuximab.

[0018] In another aspect, the present invention provides a computer-assisted method for identifying a mimetic of cetuximab comprising a processor, a data storage system, an input device, and an output device, comprising: inputting into the programmed computer through said input device data comprising the three-dimensional coordinates of at least a subset of the atoms of EGFR as set out in Table 2; providing a database of chemical and peptide structures stored in said computer data storage system; selecting from said database, using computer methods, structures having a portion that is structurally similar to said criteria data set; and outputting to said output device the selected chemical structures having a portion similar to said criteria data set.

[0019] In another aspect, the present invention provides a machine-readable medium having stored thereon a plurality of executable instructions to perform a method to identify a mimetic of cetuximab using a crystal of a receptor-antibody complex comprising a receptor- antibody complex of an epidermal growth factor receptor (EGFR) extracellular domain and cetuximab Fab, the method comprising: comparing a three-dimensional structure of a mimetic with a three dimensional structure an epidermal growth factor receptor (EGFR) extracellular domain and cetuximab Fab having an X-ray crystallography resolution of better than about 5.0 Angstroms.

[0020] Preferably the EGFR coordinates comprise at least a subset of the atomic coordinates of Table 2. In one embodiment, identifying a mimetic comprises comparing the three-dimensional structure of a mimetic with a three-dimensional structure of at least one EGFR amino acid bound by cetuximab Fab. In another embodiment identifying a mimetic comprises comparing a three dimensional structure of a mimetic with the atomic coordinates of a region of EGFR selected from the group consisting of about amino acid residue 350 to about amino acid residue 354, about amino acid residue 380 to about amino acid residue 385, about amino acid residue 405 to about amino acid residue 420, about amino acid residue 435 to about amino acid residue 475 and combinations thereof.

[0021] In another aspect, the present invention provides a machine-readable medium having stored thereon a plurality of executable instructions to perform a method for identifying a mimetic of cetuximab, the method comprising: introducing in silico substitutions in at least a single CDR region of cetuximab to obtain a pool of variants; and using a computer and at least a subset of the EGFR coordinates provided in Table 2 to select a variant with improved EGFR binding characteristics.

[0022] In another aspect, the present invention provides a cetuximab mimetic identified by any of the above methods.

[0023] In another aspect, the present invention provides a method of inhibiting EGFR comprising administering the identified mimetic.

[0024] hi another aspect, the present invention provides a method of treating a disease or condition associated with EGFR expression comprising administering the identified mimetic. In one non-limiting embodiment, the present invention provides a method of inhibiting growth of a tumor cell that expresses EGFR comprising administering the above identified mimetics. hi another embodiment, the present invention provides a method of treating a hyperproliferative diseases stimulated by a ligand of EGFR. [0025] In another aspect, the present invention provides a method of treating psoriasis comprising administering the above identified mimetics.

Brief Description of the Figures

[0026] Figure 1 provides pictures of the crystals of the present invention. In this figure crystals on the left (Ia) are representative of those used to collect the data and solve the structure. On the right (Ib) are examples of crystals grown from the same condition except without CdCl₂, which are substantially identical to that obtained in the presence of CdCl₂.

[0027] Figure 2 provides various characteristics of the crystals of the present invention.

[0028] Figure 3 provides crystal structures of EGFR and cetuximab Fab complex.

[0029] Figure 4 provides graphs depicting affinity of cetuximab Fab, and affinity of EGFR ligands for EGFR, and also provides a competition assay. Additional details are provided in the example below having the heading "BIAcore binding studies."

Detailed Description of the Invention

[0030] The present invention provides a co-crystal of EGFR extracellular domain and cetuximab Fab fragment with a resolution that is preferably greater than about 5 A, more preferably greater than about 4A and most preferably greater than about 3 A. The crystal preferably has a space group P2i and unit cell dimensions of a = 77.8 A, b = 70.9 A, c = 147.1 A; and β = 102.5°.

[0031 ] To obtain the crystal for which structural coordinates are shown Table 2, the entire extracellular region (i.e., amino acids 1-618 of mature EGFR, including domains I, II, III and IV) is used, plus a C-terminal hexa-histidine tag (Ferguson, K.M. et al., 2000, Embo J 19, 4632-4643; Ferguson, K.M. et al., 2003, MoI Cell 11, 507-517). (See GenBank Accession No. INQLA). Cetuximab Fab contains the Fab fragment of Cetuximab, i.e., the heavy and light chain variable region sequences of murine antibody M225 (U.S. App. Ser. No. 2004/0006212, incorporated herein by reference) with human IgGl CHI heavy and kappa light chain constant domains. (Cetuximab includes all three IgGl heavy chain constant domains.) The CDR regions of the heavy chain of Cetuximab have the following sequences: a CDRl region with a sequence of N Y G V H, a CDR2 region with a sequence ofV I W S G G N T D Y N T P F T S, and a CDR3 region with a sequence of A L T Y Y D Y E F A Y. The CDR regions of the light chain of Cetuximab have the following sequences: a CDRl region with a sequence of R A S Q S I G T N I H, a CDR2 region with a sequence of Y A S E S I S, and a CDR3 region with a sequence of Q Q N N N W P T T.

[0032] The sequences of the proteins in the crystal, i.e., cetuximab Fab and the extracellular domain of EGFR, are also reported with the atomic coordinates of Table 2, except for amino acid positions at which the electron density map was insufficient to place all atoms of the actual amino acid side chain. At those positions, other amino acid side chains are designated.

[0033] Crystallization of the EGFR:cetuximab Fab complex may be carried out from a solution of cetuximab Fab and EGFR with various techniques, such as microbatch, hanging drop, sitting drop, sandwich drop, seeding and dialysis. The solution is prepared by combining EGFR extracellular domain with cetuximab Fab in a suitable buffer. A standard buffering agent such as Hepes, Tris, MES and acetate may be used. The buffer system may also be manipulated by addition of a salt such as sodium chloride, ammonium sulfate, sodium/potassium phosphate, ammonium acetate among others. Imidazole may also be used as a buffer. The concentration of the salt is preferably about 1OmM to about 50OmM, more preferably about 25 mM to about 10OmM, and most preferably about 5OmM. The pH of the buffer is preferably about 6 to about 8, more preferably about 7 to about 8. The concentration of the protein in the solution is preferably that of super-saturation to allow precipitation. The solution may optionally contain a protein stabilizing agent.

[0034] In one embodiment, the crystal is precipitated by contacting the solution with a reservoir that reduces the solubility of the proteins due to presence of precipitants, i.e., reagents that induce precipitation. Such contacting may be carried out through vapor diffusion. Examples of precipitants include ammonium sulfate, ethanol, 3-ethyl-2,4 pentanediol, and glycols, particularly polyethanol glycol (PEG). The PEG utilized preferably has a molecular weight of about 400 to about 20,000, more preferably about 3000 Da, with a concentration of about 10 % to about 20 % , more preferably about 15 % (w/v). Some precipitants may act by making the buffer pH unfavorable for protein solubility.

[0035] The temperature during crystallization is preferably of about 0°C to about 30°C, more preferably about 2O⁰C to about 30°C, and most preferably about 25°C. In addition to generation of structure, the crystallization technique of the invention may also be used to increase purity of proteins.

[0036] Precipitation may also be carried out in the presence of a heavy metal such as cadmium to further improve analysis of the crystal after precipitation.

[0037] In one embodiment illustrated in the example, about 0.5 μl (or microliter) protein at 11 mg/ml in 10 mM Hepes, 50 mM NaCl, pH 7.5 is contacted with 0.5 μl (or microliter) reservoir solution of about 15 % PEG 3350, about 250 mM ammonium sulfate, about 10 mM cadmium chloride, about 100 mM imidazole and about pH 7.5. Essentially the same crystals are obtained without use of cadmium chloride. Crystals have also been grown at 15 % PEG 3450, 100 mM CaCl₂, 50 mM Sodium acetate, pH 5.0 and 15 % PEG 3450, 100 mM ammonium acetate, 50 mM sodium citrate, pH 5.0.

[0038] The atomic coordinates of the crystal of the present invention are disclosed in Table 2. The coordinates provide a three dimensional structure of the EGFR extracellular domainicetuximab Fab complex of the crystal. The cetuximab Fab includes the portion of cetuximab which binds to the extracellular region of EGFR, and can be used to model the interaction of cetuximab and EGFR. Accordingly, the crystal and the deduced atomic coordinates allows for studying the binding interaction of cetuximab with EGFR and EGFR inhibition. The three dimensional structure further allows for identifying potential mimetics by screening potential mimetics against at least part of the structure (a subset of atoms provided in Table 2).

[0039] The three dimensional structure of EGFR: cetuximab Fab complex as defined by atomic coordinates is obtained from the X-ray diffraction pattern of the crystal and the electron density map derived therefrom. One method for determining the three dimensional structure is by molecular replacement which involves use of the structure of a closely related molecule or receptor ligand complex. An alternative method employs heavy atom derivatives.

[0040] One of skill in the art will also appreciate that the atomic coordinates provided are not precise, but are obtained from electron density measured for the crystal. Initial coordinates are determined by matching the protein backbone and side chains to the electron density map. The coordinates are refined by minimizing the overall energy of the protein (e.g., by adjusting bond lengths and angles), in view of the determined electron density. In some locations in the atomic structure, atoms of amino acid side chains may not be fully resolved due to, for example, solvent interactions and the like. Accordingly, the side chain that is modeled may differ from the actual side chain at that amino acid position. For the atomic coordinates set forth in Table 2, Arg 18 of the light chain and GIn 1 of the heavy chain of cetuximab Fab are modeled as Alanine. The present invention encompasses structures having root mean square deviations of backbone atoms of not more than about 1.5 A, or more preferably not more than about 1.0 A, or most preferably, not more than about 0.5 A for residues of EGFR extracellular domain or cetuximab Fab that are used in identifying mimetics. The present invention encompasses variations within acceptable standards of error in the art for a crystal with the resolution disclosed herein.

[0041] It will also be appreciated that the origin of the atomic coordinates is arbitrarily defined. Accordingly, the same atomic structure can be represented by sets of coordinates that are numerically different, but that identify the same atomic positions. The present invention encompasses such alternative coordinate sets.

[0042] Identification of mimetics of cetuximab may be carried out with only a subset of the coordinates provided, such as those of amino acid residues of EGFR or cetuximab Fab that are associated in the complex.

[0043] Potential mimetics are examined against EGFR, particularly one or more of the above residues, through the use of computer modeling using a docking program. Such computer modeling allows for obtaining a positive initial indication of binding before synthesis and testing of the compound. If the testing shows sufficient interaction, then the compound may be synthesized and tested as a potential candidate. There is no limitation to the source of potential mimetics. For example, potential mimetics include structural databases of small molecules and other ligands represented in silico, as well as commercially available libraries of small molecules that can be similarly modeled. Potential mimetics further include peptides and macromolecules such as proteins, polypeptides, preferably antibodies or antibody fragments, synthetic polymer backbones having amino acid-like functional groups, and the like. Such potential mimetics may have defined structure, or be modeled on the basis of their similarity to other macromolecules of known structure. Iterative methods may be employed to vary one or more of the functional groups to improve the fit of the potential mimetic with EGFR. Those substances identified as mimetics, if not otherwise available to be tested for EGFR antagonist activity, may be synthesized.

[0044] In preferred embodiments, the locations of at least some atoms of cetuximab mimetics that contact EGFR correspond to the locations of atoms of cetuximab that contact EGFR. The correspondence is preferably within about 2.0 A, more preferably within about 1.0 A, and most preferably with about 0.5 A. The atoms usually interact with EGFR in a manner similar to the corresponding atoms of cetuximab Fab (i.e., polar, basic, acidic, hydrophobic). The mimetics may contain various numbers of such corresponding atoms, and binding of the mimetic to EGFR may be completely or only partially dependent on such corresponding interactions. In certain embodiments, such atomic interactions with EGFR may be supplemented by interactions of other atoms of the mimetic that also interact with EGFR. The binding ability of the mimetics can be evaluated by various computer programs as disclosed herein.

[0045] Docking may be accomplished by using software such as Quanta and Sybyl (manual model building software), followed by energy minimization and molecular dynamics with standard molecular mechanics force fields, such as CHARMM and AMBER. Specialized programs for docking include GRAM, GRID, Flexx, Glide, GOLD, MCSS, DOCK or AUTODOCK (See e.g. USP 5,856,116 and 6,087,478; Jorgensen W.L., 2004, Science 303, 1813-1818). Such procedure includes computer fitting of potential antagonists to EGFR to determine how the three dimensional structure of EGFR and the chemical properties of each amino acid interfere with EGFR activation, and to estimate attraction, repulsion and steric hindrance of the binding. Generally, tighter fits are preferred in that they are more likely to be effective when administered in vivo, and would be more selective for EGFR, minimizing binding to other receptors. Many of these programs also consider adsorption, distribution, metabolic and excretion characteristics of the molecules.

[0046] The docking program may be connected to a structure generator (such as SYNOPSIS) to perform de novo screening. An alternative to de novo screening, is creation of structures based on the binding site such as with programs including LUDI, SPROUT and BOMB, which allow a user to put a substituent in a binding site and then build up the substituent (Jorgensen W.L., 2004).

[0047] One of skill in the art would appreciate that the above screening methods may also be carried out manually, by building an actual three dimensional model based on the coordinates, and then determining desirable antagonists based on that model visually.

[0048] Of particular interest for designing mimetics are those amino acids that overlap with the binding site of EGR or TGF-α to EGFR. Such binding may interfere with the ligand- induced dimerization of the receptor or inhibit binding of the ligand to EGFR altogether.

[0049] Domains I and III of EGFR are responsible for binding of EGF to the receptor, and are of interest in designing antagonists. Of the amino acids of EGFR, some are involved in direct hydrogen bonding with cetuxiniab Fab. These amino acids include Ser 468, Asn 469, Arg 353, GIn 384, GIn 408, Ser 418, Ser 440 and/or Lys 465. Ser468 and Asn 469 are involved in main-chain hydrogen bonds, i.e., the nature of the side chain is not directly relevant. Antagonists may be designed to bind to a few, most or none of these amino acids. Other amino acids of EGFR are in contact to some lesser degree with cetuximab Fab. These amino acids include: Pro 349, Arg 353, Leu 382, His 409, Phe 412, VaI 417, Ser 418, He 438, GIy 441, Lys 443, He 466, He 467, GIn 471 and Asn 473. Of the nine amino acids between 465 and 473, eight of them are in some contact with cetuximab Fab. This region of EGFR is also ideal for screening of antagonists, particularly since residues 467 and 468 are in contact with both the heavy and light chains of cetuximab.

[0050] Cetuximab Fab does not bind to amino acids at positions 325, 346, 348, 350, 354- 357 and 411, despite these amino acids being involved in EGF/TGF-α binding. Screening may be carried out against these positions, or only for the positions bound by cetuximab Fab, or both. If screening is carried out based on the binding of cetuximab Fab to EGFR, such screening may be carried out in regions of amino acids of about 350 to about 354, amino acids of about 380 to about 385, amino acids of about 405 to about 420, amino acids of about 435 to about 475 and combinations thereof. One of skill in the art would appreciate that screening may simply be carried out against domains I and III of EGFR based on the crystal structure provided, and general area of the binding pocket, without focus on any particular amino acids bound by cetuximab Fab and/or ligands. [0051] The mimetics, both peptides and small organic molecules, preferably antibody and antibody fragments, bind to EGFR and mimic effects of cetuximab both in vivo and in vitro. In addition to peptides and small organic molecules, the mimetic may be a sugar. The mimetic may also be a combination of peptides/small molecules/sugars, such as a peptide having a synthetic backbone. The mimetic may be designed based on criteria such as affinity for EGFR, desirable efficacy and/or desirable selectivity. These mimetics have at least a single physiological or binding activity of cetuximab, which activity can be tested by assays provided further below.

[0052] As used herein, "mimetics" include cetuximab mimetics with modifications that retain specificity for EGFR. Such modifications include, but are not limited to, conjugation to an effector molecule such as a chemotherapeutic agent {e.g., cisplatin, taxol, doxorubicin) or cytotoxin (e.g., a protein, or a non-protein organic chemotherapeutic agent). The mimetics can be modified by conjugation to detectable reporter moieties. Also included are mimetics with alterations that affect non-binding characteristics such as half-life (e.g., pegylation).

[0053] Proteins and non-protein agents may be conjugated to the mimetics by methods that are known in the art. Conjugation methods include direct linkage, linkage via covalently attached linkers, and specific binding pair members (e.g., avidin-biotin). Such methods include, for example, that described by Greenfield et al., Cancer Research 50, 6600-6607 (1990) for the conjugation of doxorubicin and those described by Arnon et al., Adv. Exp. Med. Biol. 303, 79- 90 (1991) and by Kiseleva et al., MoI. Biol. (USSR)25, 508-514 (1991) for the conjugation of platinum compounds.

[0054] In one embodiment, a library of small organic molecules is used to screen for mimetics in silico. In another embodiment, cetuximab is used as a starting candidate, and varied to generate a cetuximab variant with desirable properties. Such variant of cetuximab may be a scFv, a Fab, diabody, or IgG. For example, conservative amino acid substitutions may be made at one or more of residues of cetuximab Fab which bind EGFR: light chain (LC) residues Asn 91, Trp 94; heavy chain (HC) residues GIy 54, Tyr 102, Trp 52, Asp 103.

[0055] A conservative amino acid substitution is defined as a change in the amino acid composition by way of changing one or two amino acids of a peptide, polypeptide or protein, or fragment thereof. The substitution is of amino acids with generally similar properties (e.g., acidic, basic, aromatic, size, positively or negatively charged, polarity, non-polarity) such that the substitutions do not substantially alter peptide, polypeptide or protein characteristics (e.g., charge, isoelectric point, affinity, avidity, conformation, solubility) or activity. Typical substitutions that may be performed for such conservative amino acid substitution may be among the groups of amino acids as follows: glycine (G), alanine (A), valine (V), leucine (L) and isoleucine (I); aspartic acid (D) and glutamic acid (E); alanine (A), serine (S) and threonine (T); histidine (H), lysine (K) and arginine (R): asparagine (N) and glutamine (Q); phenylalanine (F), tyrosine (Y) and tryptophan (W).

[0056] If the binding is not as tight in regard to one or more of the residues, less conservative substitutions may be made at those residues to optimize the binding. For example, an amino acid with a hydrophilic group may be substituted for one with a hydrophobic group.

[0057] In one embodiment, a mixture of all or some amino acids is introduced to synthesize variants of cetuximab randomly at specified positions in silico: Tyr 102 (HC), Trp 52 (HC), and Asp 103 (HC) of cetuximab. Only these amino acid residues are involved in side chain hydrogen bonds, and thus are candidates for specific mutations aimed at modifying direct interactions. Such variation, where all 20 amino acids are used, would result in about 20³ valiants which can then be screened. If only conservative substitutions are made, the variation would be much less, about 3 . Conservative and non-conservative substitutions at other positions in the CDRs of cetuximab that do not bind to EGFR directly should also be considered. For example, direct interactions between contact residues {e.g., main chain - main chain, main chain - side chain, side chain - side chain contacts) can be modified by introducing changes at amino acid positions that affect the position of cetuximab side chain and main chain atoms involved in direct interactions with EGFR. In one embodiment, at most a single substitution is made in each CDR. hi another embodiment a single substitution is made in the heavy chain CDR3 region of cetuximab.

[0058] After such screening and selection, the selected mimetic may be synthesized, and various assays carried out to measure the biological or physiological activity of the mimetic to select an EGFR antagonist. A preferred EGFR antagonist has one or more of the following properties: inhibits EGFR tyrosine kinase activity; blocks ligand binding to EGFR; inhibits EGFR dimerization (homodimerization with EGFR or heterodimerization with another EGFR family receptor subunit); inhibits EGFR substrate phosphorylation; inhibits EGFR mediated gene activation; inhibits growth or proliferation of a cell the expresses EGFR. Preferably, the antagonist has substantially similar or improved effectiveness as an EGFR antagonist as compared to Cetuximab.

[0059] Tyrosine kinase inhibition can be determined using well-known methods; for example, by measuring the autophosphorylation level of recombinant kinase receptor, and/or phosphorylation of natural or synthetic substrates. Thus, phosphorylation assays are useful in determining EGFR antagonists of the present invention. Phosphorylation can be detected, for example, using an antibody specific for phosphotyrosine in an ELISA assay or on a western blot. Some assays for tyrosine kinase activity are described in Panek et al., J. Pharmacol. Exp. Thera. (1997) 283: 1433-44 and Batley et al, Life Sci. (1998) 62: 143-50.

[0060] In addition, methods for detection of protein expression can be utilized to determine EGFR antagonists, wherein the proteins being measured are regulated by EGFR tyrosine kinase activity. These methods include immunohistochemistry (IHC) for detection of protein expression, fluorescence in situ hybridization (FISH) for detection of gene amplification, competitive radioligand binding assays, solid matrix blotting techniques, such as Northern and Southern blots, reverse transcriptase polymerase chain reaction (RT-PCR) and ELISA. See, e.g., Grandis et al., Cancer, (1996) 78:1284-92; Shimizu et al., Japan J. Cancer Res., (1994) 85:567-71; Sauter et al., Am. J. Path., (1996) 148:1047-53; Collins, Glia, (1995) 15:289-96; Radinsky et al., Clin. Cancer Res., (1995) 1 :19-31; Petrides et al., Cancer Res., (1990) 50:3934- 39; Hoffmann et al., Anticancer Res., (1997) 17:4419-26; Wikstrand et al., Cancer Res., (1995) 55:3140-48.

[0061 ] The ability of a mimetic to block ligand binding can be measured, for example, by an in vitro competitive assay such as is illustrated in Figure 4. In this assay, a ligand of EGFR such as EGF is immobilized, and a binding assay is carried to determine the effectiveness of the mimetic to competitively inhibit binding of EGFR to the immobilized ligand. [0062] In vivo assays can also be utilized to determine EGFR antagonists. For example, receptor tyrosine kinase inhibition can be observed by mitogenic assays using cell lines stimulated with receptor ligand in the presence and absence of inhibitor. For example, A431 cells (American Type Culture Collection (ATCC), Rockville, MD) stimulated with EGF can be used to assay EGFR inhibition. Another method involves testing for inhibition of growth of EGFR-expressing tumor cells, using for example, human tumor cells injected into a mouse. See U.S. Patent No. 6,365,157 (Rockwell et al.).

[0063] The present invention provides for coordinates of the co-crystal of the present invention on a computer readable format such as a magnetic disk, CD-ROM or a hard drive.

[0064] In another aspect, the present invention provides methods of treating EGFR- dependent diseases and conditions in mammals by administering a therapeutically effective amount of a mimetic of cetuximab. One skilled in the art would easily be able to diagnose such conditions and disorders using known, conventional tests. Treatment means any treatment of a disease in an animal and includes: (1) preventing the disease from occurring in a mammal which may be predisposed to the disease but does not yet experience or display symptoms of the disease; e.g., prevention of the outbreak of the clinical symptoms; (2) inhibiting the disease, e.g., arresting its development; or (3) relieving the disease, e.g., causing regression of the symptoms of the disease. Therapeutically effective amount for the treatment of a disease means that amount which, when administered to a mammal in need thereof, is sufficient to effect treatment, as defined above, for that disease. A cetuximab mimetic of the invention may be administered with an antineoplastic agent such as, for example, a chemotherapeutic.

[0065] Cetuximab mimetics of the present invention are useful for treating tumors that express EGFR. EGFR expressing tumors are characteristically sensitive to EGF present in their environment, and can further be stimulated by tumor produced EGF or TGF-α. While not intending to be bound to any particular mechanism, the diseases and conditions that may be treated or prevented by the present methods include, for example, those in which tumor growth is stimulated through an EGFR paracrine and/or autocrine loop. The method is therefore effective for treating a solid tumor that is not vascularized, or is not yet substantially vascularized. [0066] In another aspect of the invention, cetuximab mimetics are used to inhibit tumor- associated angiogenesis. EGFR stimulation of vascular endothelium is associated with vascularization of tumors. Typically, vascular endothelium is stimulated in a paracrine fashion by EGF and/or TGF-α from other sources (e.g., tumor cells). Accordingly, the cetuximab mimetics are effective for treating subjects with vascularized tumors or neoplasms.

[0067] Tumors that may be treated include primary tumors and metastatic tumors, as well as refractory tumors. Refractory tumors include tumors that fail to respond or are resistant to treatment with chemotherapeutic agents alone, antibodies alone, radiation alone or combinations thereof. Refractory tumors also encompass tumors that appear to be inhibited by treatment with such agents, but recur up to five years, sometimes up to ten years or longer after treatment is discontinued. The tumors may express EGFR at normal levels or they may overexpress EGFR at levels, for example, that are at least 10, 100, or 1000 times normal levels.

[0068] Examples of tumor that express EGFR and are stimulated by a ligand of EGFR include carcinomas, gliomas, sarcomas, adenocarcinomas, adenosarcomas, and adenomas. Such rumors can occur in virtually all parts of the body, including, for example, breast, heart, lung, small intestine, colon, spleen, kidney, bladder, head and neck, ovary, prostate, brain, pancreas, skin, bone, bone marrow, blood, thymus, uterus, testicles, cervix or liver. Some tumors observed to overexpress EGFR that may be treated according to the present invention include, but are not limited to, colorectal and head and neck tumors, especially squamous cell carcinoma of the head and neck, brain tumors such as glioblastomas, and rumors of the lung, breast, pancreas, esophagus, bladder, kidney, ovary, cervix, and prostate. Non-limiting examples of tumors observed to have constitutively active (i.e., unregulated) receptor tyrosine kinase activity include gliomas, non-small-cell lung carcinomas, ovarian carcinomas and prostate carcinomas. Other examples of tumors include Kaposi's sarcoma, CNS neoplasms, neuroblastomas, capillary hemangioblastomas, meningiomas and cerebral metastases, melanoma, gastrointestinal and renal carcinomas and sarcomas, rhabdomyosarcoma, glioblastoma, preferably glioblastoma multiforme, and leiomyosarcoma.

[0069] The present invention also provides a method of treating a non-cancer hyperproliferative disease in a mammal comprising administering to the mammal an effective amount of the antibody of the present invention. As disclosed herein, "hyperproliferative disease" is defined as a condition caused by excessive growth of non-cancer cells that express a member of the EGFR family of receptors. The excess cells generated by a hyperproliferative disease express EGFR at normal levels or they may overexpress EGFR.

[0070] The types of hyperproliferative diseases that can be treated in accordance with the invention are any hyperproliferative diseases that are stimulated by a ligand of EGFR or mutants of such ligands. Examples of hyperproliferative disease include psoriasis, actinic keratoses, and seborrheic keratoses, warts, keloid scars, and eczema. Also included are hyperproliferative diseases caused by virus infections, such as papilloma virus infection. For example, psoriasis comes in many different variations and degrees of severity. Different types of psoriasis display characteristics such as pus-like blisters (pustular psoriasis), severe sloughing of the skin (erythrodermic psoriasis), drop-like dots (guttae psoriasis) and smooth inflamed lesions (inverse psoriasis). The treatment of all types of psoriasis (e. g., psoriasis vulgaris, psoriasis pustulosa, psoriasis erythrodermica, psoriasis arthropathica, parapsoriasis, palmoplantar pustulosis) is contemplated by the invention.

[0071] Administering the cetuximab mimetic includes delivering the mimetic to a mammal by any method that may achieve the result sought. The term mammal as used herein is intended to include, but is not limited to, humans, laboratory animals, domestic pets and farm animals. The mimetic may be administered, for example, orally, parenterally (intravenously or intramuscularly), topically, transdermally or by inhalation. Topical administration may be preferred for certain hyperproliferative disorders.

[0072] In an embodiment of the invention, cetuximab mimetic can be administered in combination with one or more other anti-neoplastic agents, such as chemotherapeutic agents. Radiation can also be employed. For examples of combination therapies, see, e.g., U.S. Patent No. 6,217,866 (Schlessinger et al.) (Anti-EGFR antibodies in combination with anti-neoplastic agents); WO 99/60023 (Waksal et al.) (Anti-EGFR antibodies in combination with radiation). Any suitable anti-neoplastic agent can be used, such as a chemotherapeutic agent, radiation or combinations thereof. The anti-neoplastic agent can be an alkylating agent or an anti¬ metabolite. Examples of alkylating agents include, but are not limited to, cisplatin, cyclophosphamide, melphalan, and dacarbazine. Examples of anti-metabolites include, but not limited to, doxorubicin, daunorubicin, paclitaxel, irinotecan (CPT-11), and topotecan. When the agent is radiation, the source of the radiation can be either external (external beam radiation therapy - EBRT) or internal (brachytherapy - BT) to the patient being treated. The dosage administered depends on numerous factors, including, for example, the type of agent, the type and severity tumor being treated and the route of administration of the agent. It should be emphasized, however, that the present invention is not limited to any particular dose.

[0073] For treatment of hyperproliferative disease, the cetuximab mimetic can be combined with any conventional treatment agent. For example, when the hyperproliferative disease is psoriasis, there are a variety of conventional systemic and topical agents available. Systemic agents for psoriasis include methotrexate, and oral retinoids, such as acitretin, etretinate, and isotretinoin. Other systemic treatments of psoriasis include hydroxyurea, NSAIDS, sulfasalazine, and 6-thioguanine. Antibiotics and antimicrobials can be used to treat or prevent infection that can cause psoriasis to flare and worsen. Topical agents for psoriasis include anthralin, calcipotriene, coal tar, corticosteroids, retinoids, keratolytics, and tazarotene. Topical steroids are one of the most common therapies prescribed for mild to moderate psoriasis. Topical steroids are applied to the surface of the skin, but some are injected into the psoriasis lesions.

[0074] Hyperproliferative disease treatments further include administration of the cetuximab mimetic in combination with phototherapy. Phototherapy includes administration of any wavelength of light that reduces symptoms of the hyperproliferative disease, as well as photoactivation of a chemotherapeutic agent (photochemotherapy). For further discussion of treatment of hyperproliferative disorders, see WO 02/11677 (Teufel et al.) (Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists).

[0075] In certain embodiments of the invention, cetuximab mimetics of the invention can be administered with EGFR antagonists and/or antagonists of other receptors involved in tumor growth or angiogenesis. The receptor antagonists may bind to the receptor or the ligand to block receptor-ligand binding, or the receptor antagonists may otherwise neutralize the receptor tyrosine kinase. Ligands of EGFR include, for example, EGF, TGF-α amphiregulin, heparin-binding EGF (HB-EGF) and betacellulin. EGF and TGF-α are thought to be the main endogenous ligands that result in EGFR-mediated stimulation, although TGF-α has been shown to be more potent in promoting angiogenesis. Accordingly, EGFR antagonists include antibodies that bind to such ligands and thereby block binding to and activation of EGFR.

[0076] The cetuximab mimetic can be used in combination with a VEGFR antagonist. In one embodiment of the invention, a cetuximab mimetic is used in combination with a receptor antagonist that binds specifically to VEGFR-2/KDR receptor (PCT7TJS92/01300, filed Feb. 20, 1992; Terman et al., Oncogene 6: 1677-1683 (1991)). In another embodiment of the invention, a cetuximab mimetic is used in combination with a receptor antagonist that binds specifically to VEGFR-l/Flt-1 receptor (Shibuya M. et al., Oncogene 5, 519-524 (1990)). In another embodiment, a cetuximab mimetic is used in combination with a receptor antagonist that binds to a VEGFR ligand. For example, Avastin^® (bevacizumab) is an antibody that binds VEGF. Particularly preferred are antigen-binding proteins that bind to the extracellular domain of VEGFR-I or VEGFR-2 and block binding by ligand (VEGF or PlGF), and/or neutralize VEGF- induced or PlGF-induced activation. For example, Mab IMC-1121 binds to soluble and cell surface-expressed KDR. Mab IMC-1121 comprises the V_H and V_L domains obtained from a human Fab phage display library. (See WO 03/075840) hi another example, ScFv 6.12 binds to soluble and cell surface-expressed FIt-I. ScFv 6.12 comprises the V_H and V_L domains of mouse monoclonal antibody MAb 6.12. A hybridoma cell line producing MAb 6.12 has been deposited as ATCC number PTA-3344.

[0077] In another embodiment, a cetuximab mimetic is administered with an antagonist of insulin-like growth factor receptor (IGFR). In certain tumor cells, inhibition of EGFR function can be compensated by upregulation of other growth factor receptor signaling pathways, and particularly by IGFR stimulation. Further, inhibition of IGFR signaling results in increased sensitivity of tumor cells to certain therapeutic agents. Stimulation of either EGFR or IGFR results in phosphorylation of common downstream signal transduction molecules, including Akt and p44/42, although to different extents. Accordingly, in an embodiment of the invention, an IGFR antagonist (e.g., an antibody that binds to IGF or IGFR and neutralizes the receptor) is coadministered with a cetuximab mimetic of the invention, thereby blocking a second input into the common downstream signaling pathway (e.g., inhibiting activation of Akt and/or p44/42). An example of a human antibody specific for IGFR is IMC-Al 2 (See WO 2005/016970). [0078] Other examples of growth factor receptors involved in tumorigenesis against which antagonists may be directed are the receptors for platelet-derived growth factor (PDGFR), hepatocyte growth factor (HGFR), nerve growth factor (NGFR), fibroblast growth factor (FGFR), and macrophage stimulating protein (RON).

[0079] The cetuximab mimetics can also be administered with intracellular RTK antagonists that inhibit activity of RTKs or their associated downstream signaling elements that are involved in tumor growth or tumor-associated angiogenesis. The intracellular RTK antagonists are preferably small molecules. Some examples of small molecules include organic compounds, organometallic compounds, salts of organic compounds and organometallic compounds, and inorganic compounds. Atoms in a small molecule are linked together via covalent and ionic bonds; the former is typical for small organic compounds such as small molecule tyrosine kinase inhibitors and the latter is typical of small inorganic compounds. The arrangement of atoms in a small organic molecule may represent a chain, e.g. a carbon-carbon chain or carbon-heteroatom chain or may represent a ring containing carbon atoms, e.g. benzene or a policyclic system, or a combination of carbon and heteroatoms, i.e., heterocycles such as a pyrimidine or quinazoline. Although small molecules can have any molecular weight, they generally include molecules that would otherwise be considered biological molecules, except their molecular weight is not greater than 650 D. Small molecules include both compounds found in nature, such as hormones, neurotransmitters, nucleotides, amino acids, sugars, lipids, and their derivatives as well as compounds made synthetically, either by traditional organic synthesis, bio-mediated synthesis, or a combination thereof. See e.g. Ganesan, Drug Doscov. Today 7(1): 47-55 (Jan. 2002); Lou, Drug Discov. Today, 6(24): 1288-1294 (Dec. 2001).

[0080] More preferably, the small molecule to be used as an intracellular RTK antagonist according to the present invention is an intracellular EGFR antagonist that competes with ATP for binding to EGFR's intracellular binding region having a kinase domain or to proteins involved in the signal transduction pathways of EGFR activation. Examples of such signal transduction pathways include the ras-mitogen activated protein kinase (MAPK) pathway, the ρhosphatidylinosital-3 kinase (P13K)-Akt pathway, the stress-activated protein kinase (SAPK) pathway, and the signal transducers and activators of transcription (STAT) pathways. Non-limiting examples of proteins involved in such pathways (and to which a small molecule EGFR antagonist according to the present invention can bind) include GRB-2, SOS, Ras, Raf, MEK, MAPK, and matrix metalloproteinases (MMPs).

[0081] One example of a small molecule EGFR antagonist is IRESSA™ (ZD1939), which is a quinozaline derivative that functions as an ATP -mimetic to inhibit EGFR. See U.S. Patent No. 5,616,582 (Zeneca Limited); WO 96/33980 (Zeneca Limited) at p. 4; see also, Rowinsky et ah, Abstract 5 presented at the 37th Annual Meeting of ASCO, San Francisco, CA, 12-15 May 2001; Anido et ah, Abstract 1712 presented at the 37th Annual Meeting of ASCO, San Francisco, CA, 12-15 May 2001. Another example of a small molecule EGFR antagonist is TARCEVA™ (OSI-774), which is a 4-(substitutedphenylamino)quinozaline derivative [6,7- Bis(2-methoxy-ethoxy)-quinazolin-4-yl]- (3-ethynyl-phenyl)amine hydrochloride] EGFR inhibitor. See WO 96/30347 (Pfizer Inc.) at, for example, page 2, line 12 through page 4, line 34 and page 19, lines 14-17. See also Moyer et ah, Cancer Res., 57: 4838-48 (1997); Pollack et ah, J. Pharmacol., 291 : 739-48 (1999). TARCEVA™ may function by inhibiting phosphorylation of EGFR and its downstream PI3/Akt and MAP (mitogen activated protein) kinase signal transduction pathways resulting in p27-mediated cell-cycle arrest. See Hidalgo et ah, Abstract 281 presented at the 37th Annual Meeting of ASCO, San Francisco, CA, 12-15 May 2001.

[0082] Other small molecules are also reported to inhibit EGFR, many of which are thought to being to the tyrosine kinase domain of an EGFR. Some examples of such small molecule EGFR antagonists are described in WO 91/116051, WO 96/30347, WO 96/33980, WO 97/27199 (Zeneca Limited). WO 97/30034 (Zeneca Limited), WO 97/42187 (Zeneca Limited), WO 97/49688 (Pfizer Inc.), WO 98/33798 (Warner Lambert Company), WO 00/18761 (American Cyanamid Company), and WO 00/31048 (Warner Lambert Company). Examples of specific small molecule EGFR antagonists include Cl-1033 (Pfizer), which is a quinozaline (N- [4-(3 -chloro-4-fluoro-phenylamino)-7-(3 -morpholin-4-yl-propoxy)-quinazolin-6-yl] -acrylamide) inhibitor of tyrosine kinases, particularly EGFR and is described in WO 00/31048 at page 8, lines 22-6; PKIl 66 (Novartis), which is a pyrrolopyrimidine inhibitor of EGFR and is described in WO 97/27199 at pages 10-12; GW2016 (GlaxoSmithKline), which is an inhibitor of EGFR and HER2; EKB569 (Wyeth), which is reported to inhibit the growth of rumor cells that overexpress EGFR or HER2 in vitro and in vivo; AG-1478 (Tryphostin), which is a quinazoline small molecule that inhibits signaling from both EGFR and erbB-2; AG-1478 (Sugen), which is bisubstrate inhibitor that also inhibits protein kinase CK2; PD 153035 (Parke-Davis) which is reported to inhibit EGFR kinase activity and tumor growth, induce apoptosis in cells in culture, and enhance the cytotoxicity of cytotoxic chemotherapeutic agents; SPM-924 (Schwarz Pharma), which is a tyrosine kinase inhibitor targeted for treatment of prostrate cancer; CP- 546,989 (OSI Pharmaceuticals), which is reportedly an inhibitor of angiogenesis for treatment of solid tumors; ADL-681, which is a EGFR kinase inhibitor targeted for treatment of cancer; PD 158780, which is a pyridopyrimidine that is reported to inhibit the tumor growth rate of A4431 xenografts in mice; CP-358,774, which is a quinzoline that is reported to inhibit autophosphorylation in HN5 xenografts in mice; ZD 1839, which is a quinzoline that is reported to have antitumor activity in mouse xenograft models including vulvar, NSCLC, prostrate, ovarian, and colorectal cancers; CGP 59326A, which is a pyrrolopyrimidine that is reported to inhibit growth of EGFR-positive xenografts in mice; PD 165557 (Pfizer); CGP54211 and CGP53353 (Novartis), which are dianilnophthalimides. Naturally derived EGFR tyrosine kinase inhibitors include genistein, herbimycin A, quercetin, and erbstatin.

[0083] Further small molecules reported to inhibit EGFR and that are therefore within the scope of the present invention are tricyclic compounds such as the compounds described in U.S. Patent No. 5,679,683; quinazoline derivatives such as the derivatives described in U.S. Patent No. 5,616,582; and indole compounds such as the compounds described in U.S. Patent No. 5,196,446.

[0084] In another embodiment, the EGFR antagonist can be administered in combination with one or more suitable adjuvants, such as, for example, cytokines (IL-10 and IL- 13, for example) or other immune stimulators, such as, but not limited to, chemokine, tumor-associated antigens, and peptides. See, e.g., Larrivee et al., supra. It should be appreciated, however, that administration of only a cetuximab mimetic is sufficient to prevent, inhibit, or reduce the progression of the tumor in a therapeutically effective manner.

[0085] For combination therapies, the cetuximab mimetic and anti-neoplastic agent or receptor antagonist may be administered concomitantly or sequentially.

[0086] This invention also provides a pharmaceutical composition/formulation containing a cetuximab mimetic and a pharmaceutically acceptable carrier. Carrier as used herein include pharmaceutically acceptable carriers, excipients, or stabilizers which are nontoxic to the cell or mammal being exposed thereto at the dosages and concentrations employed. Often the physiologically acceptable carrier is an aqueous pH buffered solution. Examples of physiologically acceptable carriers include buffers such as phosphate, citrate and other organic acids; antioxidants including ascorbic acid; low molecular weight (less than about 10 residues) polypeptide; proteins, such as serum albumin, gelatin; hydrophilic polymers such as polyvinylpyrrolidone; amino acids such as glycine, glutamine, asparagine, arginine or lysine; monosaccharides, disaccharides, and other carbohydrates including glucose, mannose, or dextrins; chelating agents such as EDTA; sugar alcohols such as mannitol or sorbitol; salt forming counterions such as sodium; and/or nonionic surfactants such as TWEEN®, polyethylene glycol (PEG), and PLURONICS®.

[0087] The active ingredients may also be entrapped in microcapsules prepared, for example, by interfacial polymerization, for example, hydroxymethylcellulose or gelatin- microcapsules and poly(methylmethacylate) microcapsules, respectively, in colloidal drug delivery systems (for example, liposomes, albumin microspheres, microemulsions, nano- particles, and nanocapsules) or in macroemulsions. The formulations to be used for in vivo administration must be sterile. This is readily accomplished by filtration through sterile filtration membranes. Sustained-release preparations may be prepared. Suitable examples of sustained-release preparations include semipermeable matrices of solid hydrophobic polymers containing the antibody, which matrices are in the form of shaped articles, e.g., Sims, or microcapsules. Examples of sustained-release matrices include polyesters, hydrogels (for example, poly(2-hydroxyethyl-methacrylate), or poly(vinylalcohol)), polylactides (U.S. Pat. No. 3,773,919), copolymers of L-glutamic acid and γ- ethyl-L-glutamate, non-degradable ethylene- vinyl acetate, degradable lactic acid-glycolic acid copolymers such as the LUPRON DEPOT® (injectable microspheres composed of lactic acid-glycolic acid copolymer and leuprolide acetate), and poly-D-(-)-3-hydroxybutyric acid. While polymers such as ethylene- vinyl acetate and lactic acid-glycolic acid enable release of molecules for over 100 days, certain hydrogels release proteins for shorter time periods.

[0088] The present invention also includes kits for inhibiting tumor growth and/or tumor-associated angiogenesis comprising a therapeutically effective amount of a cetuximab mimetic. The kits can further contain any suitable antagonist of, for example, another growth factor receptor involved in tumorigenesis or angiogenesis (e.g., VEGFR-I /Flt-1, VEGFR-2, PDGFR, IGFR, NGFR, FGFR, etc, as described above). Alternatively, or in addition, the kits of the present invention can further comprise an anti-neoplastic agent. Examples of suitable anti¬ neoplastic agents in the context of the present invention have been described herein. The kits of the present invention can further comprise an adjuvant; examples have also been described above.

[0089] Moreover, included within the scope of the present invention is use of the present antibodies in vivo and in vitro for investigative or diagnostic methods, which are well known in the art. The diagnostic methods include kits, which contain mimetics of the present invention.

[0090] Accordingly, the mimetics can be used in vivo and in vitro for investigative, diagnostic, prophylactic, or treatment methods, which are well known in the art. Of course, it is to be understood and expected that variations in the principles of invention herein disclosed can be made by one skilled in the art and it is intended that such modifications are to be included within the scope of the present invention.

[0091] All references mentioned herein are incorporated by reference. EXAMPLES

[0092] The following examples are offered for illustrative purposes only, and are not intended to limit the scope of the present invention in any way.

[0093] Protein expression and purification. sEGFR was produced and purified from baculovirus-infected Sf9 cells as described by Ferguson, K.M. et al., 2000, Embo J 19, 4632- 4643, and was used without modification of its glycosylation state. This sEGFR was further purified by size exclusion chromatography (SEC) using a SEC250 column (BioRad) pre- equilibrated with 25 niM HEPES, 100 mM NaCl, pH 7.5 and concentrated to 6.2 mg/ml. Cetuximab Fab fragment was prepared by treatment of the IgG protein with papain. The IgG protein (20 mg/ml) was incubated with papain (1:1000 w:w) at 37⁰C for one hour and the digestion was terminated by addition of iodoacetemide (75 mM final concentration). The reaction mixture was loaded onto a Protein-A column and the flow-through fraction containing the Fab fragments was collected and concentrated. The cetuximab Fab was fractionated by SEC and mixed with sEGFR to give a two fold molar excess of Fab over sEGFR. Excess Fab was separated from the sEGFR:Fab complex using the same SEC column. The peak fractions containing the sEGFR:Fab complex (as confirmed by SDS-PAGE), were concentrated to 11 mg/ml.

[0094] Crystallization and data collection. The sEGFR:Fab complex was buffer- exchanged into 25mM HEPES, pH 7.5, containing 5OmM NaCl, and crystallized by the hanging drop method from a drop containing equal parts of a 78 μM sEGFR:Fab complex solution and reservoir solution of 15 % PEG3350, 250 rnM (NH₄)₂SO₄, 100 mM imidazole, 10 mM CdCl₂, pH 7.5. Streak seeding was used to produce large (0.08 X 0.08 X 0.6 mm) single crystals. Crystals were cryo-stabilized with a brief exposure to 15 % PEG3350, 15 % Ethylene Glycol, 250 mM (NH₄)₂SO₄, 100 mM imidazole, 10 mM CdCl₂, pH 7.5, and were flash frozen in liquid nitrogen. Data were collected at CHESS beamline Al, using an ADSC Quantum-210 CCD detector, and were processed using HKL2000 (See, Otwinowski, Z., and Minor, W. (1997). Processing of X-ray Diffraction Data Collected in Oscillation Mode. In Macromolecular Crystallography, Volume 276, CW. Carter Jr. and R.M. Sweet, eds. (New York: Academic Press), pp. 307-326.

[0095] Structure determination and refinement. Search models for molecular replacement were derived from the coordinates of tethered sEGFR (pdb id. INQL;. Ferguson, K.M. et al., 2003) and those of the structure of the Fab fragment alone (P. Jeffrey and P. Kussie unpublished data). An initial solution was found for a domain I/II fragment (amino acids 5 - 240) combined with a domain III fragment of sEGFR using the dyad option of MOLREP (The CCP4 Suite: Programs for Protein Crystallography. Acta Cryst. D50, 760-763 (1990)) to search for the best relative orientation of these two fragments. With the solution for these fragments fixed it was possible to find a solution for the Fab fragment. Rigid body refinement with CNS was used to optimize the orientation of the individual sub-domains of the Fab. Following several rounds of model building using 'O' (Jones, T.A. et al., 1991, Acta Crystallogr A 47 (Pt 2), 110-119) and refinement using CNS (Brunger, A.T. et al., 1998, Acta Crystallogr D Biol Crystallogr 54 (Pt 5), 905-921), interpretable density for the remaining portions of sEGFR (C- terminal part of domain II and domain IV) could be seen in composite simulated-annealing omit-maps (calculated with CNS). The final stages of refinement employed TLS refinement (Winn, M.D. et al., 2001, Acta Crystallogr D Biol Crystallogr 57, 122-133) with anisotropic motion tensors refined for each of the four domains of sEGFR and each of the domains of the Fab, using REFMAC5 (The CCP4 Suite: Programs for Protein Crystallography. Acta Cryst. D50, 760-763 (1990).

[0096] BIAcore binding studies. Surface plasmon resonance binding experiments, performed using a BIAcore 3000 instrument, were performed in 1OmM Hepes buffer, pH 8.0, that contained 15OmM NaCl, 3mM EDTA, and 0.005% Tween 20 (HBS-EP8) at 25°C. EGF- agonists (200 μg/ml) were coupled to a CM5 BIAcore sensor chip using standard amine coupling. Optimal coupling was obtained in 10 niM sodium acetate at pH 4.0 for EGF and TGFα and at pH 6.0 for HB-EGF. Binding of sEGFR to these immobilized ligands was performed and analyzed exactly as described in Ferguson, K.M. et al., 2000 (Figure 4c). The Fab fragment of cetuximab was coupled to a separate sensor chip using amine coupling. The Fab was diluted to 50 μg/ml in 10 niM sodium acetate at pH 5.5 and passed over the activated surface for 5 minute at a flow rate 10 μl/minute. The binding of sEGFR to this surface was determined exactly as for sEGFR binding to immobilized EGF (Ferguson, K.M. et al., 2000 ) with the following modifications; a long contact time was used (10 μl/min for 20 minutes; 200 μl injection) to ensure that equilibrium was reached in binding of sEGFR to the surface even at low concentration, the surface was regenerated between data points with two 5 μl injections of 10 mM glycine, IM NaCl (pH 3.0) to rapidly remove residual bound sEGFR. This regeneration does not impair the binding of sEGFR to the Fab; the observed response for a control sEGFR sample is constant over multiple cycles of binding and regeneration (Figure 4(a)).

[0097] The effect of added Fab upon the binding of sEGFR to immobilized ligand was determined using the same EGF-agonist chip described above. A series of samples were prepared that contained 600 nM sEGFR and increasing amounts of Fab. The fraction of the maximal response in the absence of added Fab is plotted for each ligand (Figure 4(b)).

[0098] EGFR: Cetuximab Fab Interface. The following amino acids are involved in direct hydrogen bonds with the Fab (3.25 A cut-off, calculated using the program CONTACT (CCP4)): sEGFR Cetuximab* Cetuximab* Type

Light Chain Heavy Chain

Ser 468 Asn 91 Main chain - main chain

Asn 469 Trp 94 Main chain — main chain

Arg 353 GIy 54 Side chain — main chain

GIn 384 Tyr lO2 Side chain — side chain

GIn 408 Tyr lO2 Side chain - side chain

Ser 418 Trp 52 Side chain - side chain

Ser 440 Tyr lO2 Side chain - main chain

Lys 465 Asp 103 Side chain — side chain

*amino acids in the Fab are numbered in a simple sequential manner.

Additional amino acids that are close (4 A cut-off) are shown on the following sequence.

310 320 330 340 350 360 Bl RKVCNGIGIG EFKDSLSINA TNIKHFKNCT SISGDLHILP VAFRGDSFTH TPPLDPQELD

370 380 390 400 410 420 ILKTVKEITG FLLIQAWPEN RTDLHAFENL EIIRGRTKQH GQFSLAWSL NITSLGLRSL

430 440 450 460 470 KEISDGDVII SGNKNLCYAN TINWKKLFGT SGQKTKIISN RGENSCKA

Bold Fab Heavy chain

Underlined and Italic Fab Light chain Italic Both chains of Fab

The binding site for cetuximab Fab is partially over-lapping with the ligand binding site. The following amino acids are involved in contact to TGFα or EGF, as reported by Garrett et al. and Ogiso et al.

310 320 330 340 350 360 Bl RKVCNGIGIG EFKDSLSINA TNIKHFKNCT SISGDLHILP VAFRGDSFTH TPPLDPQELD

370 380 390 400 410 420 ILKTVKEITG FLLIQAWPEN RTDLHAFENL EIIRGRTKQH GQFSLAVVSL NITSLGLRSL

430 440 450 460 470 KEISDGDVII !3GNKNLCYAN TINWKKLFGT SGQKTKIISN RGENSCKA

Underlined EGF/TGFα Table 1. Data collection and refinement statistics

Data Collection Statistics³

Space group P2i

Unique cell dimensions a = 77.8 A, b = 70.9 A, c = 147.1 A; β = 102.5°

X-ray source CHESS Al

Resolution limit 2.8A

Observed/unique 1411,255/38,478

Completeness 99.8 (90.6)

•K-sym 0.03 (0.33)

<I/σ> 17 (5.6)

Refinement Statistics

Resolution limits 500-2.8A

No. of reflections/no, test set 38098/1900

R factor (R_free)^c 0.22 (0.27)

Model

Protein sEGFR - aa 1-614

Fab: Light chain; aa 1-211, Heavy Chain; aa 1-220,

25 saccharide units

Total number of atoms 8131

RMSD bond lengths (A) 0.028 A RMSD bond angles (°) 2.63° a Numbers in parentheses refer to last resolution shell b R_sy_m ⁼ ∑jlh-^<l_h ^>]/∑l_h5 where <I_h> = average intensity over symmetry equivalent measurements c R factor = Σ|F₀-F₀|/ΣF₀, where summation is over data used in the refinement; R_free includes only 5% of the data excluded from the refinement Table 2:

HEADER HORMONE/GROWTH FACTOR RECEPTOR

TITLE STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN EPIDERMAL

TITLE 2 GROWTH FACTOR (EGF) RECEPTOR IN AN COMPLEX WITH IMC-C225

TITLE 3 (CETUXIMBA/ERBITUX) .

COMPND MOL_ID: 1;

COMPND 2 MOLECULE: EPIDERMAL GROWTH FACTOR RECEPTOR;

COMPND 3 CHAIN: A;

COMPND 4 FRAGMENT: EXTRACELLULAR DOMAIN;

COMPND 5 ENGINEERED: YES;

COMPND 6 MOL_ID: 2;

COMPND 7 MOLECULE: FAB FRAGMENT FROM CETUXIMAB;

COMPND 8 CHAIN: C;

COMPND 9 CHAIN: D;

COMPND 10 SYNONYM: IMC-C225, ERBITUX;

COMPND 11 ENGINEERED: YES

SOURCE MOL_ID: 1;

SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;

SOURCE 3 ORGANISM_COMMON: HUMAN;

SOURCE 4 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;

SOURCE 5 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;

SOURCE 6 EXPRESSION_SYSTEM_STRAIN: VIRUS;

SOURCE 7 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;

SOURCE 8 MOL_ID: 2;

SOURCE PROVIDED BY IMCLONE INC. AS FAB FRAGMENT

EXPDTA X-RAY DIFFRACTION

REMARK 1

REMARK 2 RESOLUTION. 2.80 ANGSTROMS.

REMARK REFINEMENT.

REMARK PROGRAM REFMAC 5.1.24

REMARK AUTHORS MURSHUDOV,VAGIN,DODSON

REMARK

REMARK REFINEMENT TARGET : MAXIMUM LIKELIHOOD

REMARK

REMARK DATA USED IN REFINEMENT.

REMARK RESOLUTION RANGE HIGH (ANGSTROMS) : 2.81

REMARK RESOLUTION RANGE LOW (ANGSTROMS) : 50.00

REMARK DATA CUTOFF (SIGMA(F)) : NONE

REMARK COMPLETENESS FOR RANGE (%) : 99.44

REMARK NUMBER OF REFLECTIONS : 36547

REMARK

REMARK FIT TO DATA USED IN REFINEMENT.

REMARK CROSS-VALIDATION METHOD THROUGHOUT

REMARK FREE R VALUE TEST SET SELECTION RANDOM

REMARK R VALUE (WORKING + TEST SET) 0.22623

REMARK R VALUE (WORKING SET) 0.22396

REMARK FREE R VALUE 0.26877

REMARK FREE R VALUE TEST SET SIZE (%) 5.0

REMARK FREE R VALUE TEST SET COUNT 1931

REMARK

REMARK FIT IN THE HIGHEST RESOLUTION BIN.

REMARK TOTAL NUMBER OF BINS USED 20

REMARK BIN RESOLUTION RANGE HIGH 2.805

REMARK BIN RESOLUTION RANGE LOW 2.878

REMARK REFLECTION IN BIN (WORKING SET) 2605

REMARK BIN R VALUE (WORKING SET) 0.335

REMARK BIN FREE R VALUE SET COUNT 141

REMARK BIN FREE R VALUE 0.381

REMARK

REMARK NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.

REMARK ALL ATOMS : 8131

REMARK

REMARK B VALUES.

REMARK FROM WILSON PLOT (A**2) NULL

REMARK MEAN B VALUE (OVERALL, A**2) 7.403

REMARK OVERALL ANISOTROPIC B VALUE. REMARK BIl (A**2) 1.07

REMARK B22 (A**2) 0.32

REMARK B33 (A**2) -1 ,83

REMARK B12 (A**2) 0.00

REMARK B13 (A**2) -1 ,01

REMARK B23 (A**2) 0.00

REMARK

REMARK ESTIMATED OVERALL COORDINATE ERROR.

REMARK ESU BASED ON R VALUE (A): 0.910

REMARK ESU BASED ON FREE R VALUE (A): 0.362

REMARK ESU BASED ON MAXIMUM LIKELIHOOD (A): 0.295

REMARK ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2) : 15.477

REMARK

REMARK CORRELATION COEFFICIENTS.

REMARK CORRELATION COEFFICIENT FO-FC : 0.925

REMARK CORRELATION COEFFICIENT FO-FC FREE : 0.888

REMARK

REMARK RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT

REMARK BOND LENGTHS REFINED ATOMS (A) 8349 0.028 0 . 021

REMARK BOND LENGTHS OTHERS (A) 7109 0.002 0 . 020

REMARK BOND ANGLES REFINED ATOMS (DEGREES) 11411 2.623 1 . 993

REMARK BOND ANGLES OTHERS (DEGREES) 16529 1.130 3 . 000

REMARK TORSION ANGLES, PERIOD 1 (DEGREES) 1042 9.222 5 . 000

REMARK CHIRAL-CENTER RESTRAINTS (A**3) 1349 0.132 0 . 200

REMARK GENERAL PLANES REFINED ATOMS (A) 9136 0 009 0 . 020

REMARK GENERAL PLANES OTHERS (A) 1532 0.007 0 . 020

REMARK NON-BONDED CONTACTS REFINED ATOMS (A) 1896 0.255 0 . 200

REMARK NON-BONDED CONTACTS OTHERS (A) 8610 0.250 0 . 200

REMARK NON-BONDED TORSION OTHERS (A) 5383 0.106 0 . 200

REMARK H-BOND (X...Y) REFINED ATOMS (A) 146 0.207 0 . 200

REMARK SYMMETRY VDW REFINED ATOMS (A) 11 0.149 0 . 200

REMARK SYMMETRY VDW OTHERS (A) 51 0.288 0 . 200

REMARK SYMMETRY H-BOND REFINED ATOMS (A) 3 0.346 0 . 200

REMARK

REMARK ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT

REMARK MAIN-CHAIN BOND REFINED ATOMS (A**2) : 5197 ; 0.717 1 . 500

REMARK MAIN-CHAIN ANGLE REFINED ATOMS (A**2) : 8355 ; 1.289 2 . 000

REMARK SIDE-CHAIN BOND REFINED ATOMS (A**2) : 3152 ; 2.076 3 . 000

REMARK SIDE-CHAIN ANGLE REFINED ATOMS (A**2) : 3056 ; 3.116 4 . 500

REMARK

REMARK NCS RESTRAINTS STATISTICS

REMARK NUMBER OF NCS GROUPS : NULL

REMARK

REMARK BULK SOLVENT MODELLING.

REMARK METHOD USED : BABINET MODEL WITH MASK

REMARK PARAMETERS FOR MASK CALCULATION

REMARK VDW PROBE RADIUS 40

REMARK ION PROBE RADIUS 80

REMARK SHRINKAGE RADIUS 80

REMARK

REMARK OTHER REFINEMENT REMARKS:

REMARK HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

REMARK

LINK Cl NAG E3281 1.439 ND2 ASN A 328 NAG- -ASN

LINK Cl NAG E3371 1.439 ND2 ASN A 337 NAG- ^■ASN

LINK Cl NAG E3891 1.439 ND2 ASN A 389 NAG- ^■ASN

LINK Cl NAG E5441 1.439 ND2 ASN A 544 NAG- ^■ASN

LINK Cl NAG E5791 1.439 ND2 ASN A 579 NAG- ^■ASN

LINK Cl NAG E 881 1.439 ND2 ASN D 88 NAG- ^•ASN

LINK 03 NAG E 321 N2 NAG E 322 NAG- ^■NAG

LINK 03 NAG E 321 C7 NAG E 322 NAG- NAGl

LINK 03 NAG E 321 07 NAG E 322 NAG- ^■NAG2

LINK 02 MAN E 324 1.080 02 MAN E 323 MAN- ^■MAN

CISPEP 1 SER C 7 PRO C 8 0. 00

CISPEP 2 TYR C 140 PRO C 1 0. 00

CISPEP 3 PHE D 152 PRO D 3 0. 00

CISPEP 4 GLU D 154 PRO D 5 0. 00

LINK NAG E3281 NAG E3282 BETAl- 4 LINK NAG E3282 MAN E3283 BETAl-4

LINK MAN E3283 MAN E3284 BETAl-6

LINK MAN E3284 MAN E3287 ALPHAl-3

LINK MAN E3287 MAN E3288 BETA1-2

LINK MAN E3: 283 MAN E3285 ALPHAl-3

LINK MAN E3285 MAN E3286 BETAl-2

LINK MAN E3284 MAN E3289 ALPHAl-6

LINK NAG E3371 NAG E3372 ALPHAl-4

LINK NAG E3372 MAN E3373 ALPHAl-4

LINK MAN E3373 MAN E3374 BETAl-3

LINK NAG E4201 NAG E4202 ALPHAl-4

LINK NAG E4202 MAN E4203 ALPHAl-4

SSBOND 1 CYS A 34 CYS A 7

SSBOND 2 CYS A 163 CYS A 133

SSBOND 3 CYS A 175 CYS A 166

SSBOND 4 CYS A 183 CYS A 170

SSBOND 5 CYS A 207 CYS A 195

SSBOND 6 CYS A 216 CYS A 208

SSBOND 7 CYS A 224 CYS A 212

SSBOND 8 CYS A 236 CYS A 227

SSBOND 9 CYS A 283 CYS A 271

SSBOND 10 CYS A 302 CYS A 287

SSBOND 11 CYS A 309 CYS A 305

SSBOND 12 CYS A 338 CYS A 313

SSBOND 13 CYS A 499 CYS A 486

SSBOND 14 CYS A 511 CYS A 502

SSBOND 15 CYS A 531 CYS A 515

SSBOND 16 CYS A 547 CYS A 534

SSBOND 17 CYS A 555 CYS A 538

SSBOND 18 CYS A 567 CYS A 558

SSBOND 19 CYS A 593 CYS A 571

SSBOND 20 CYS A 604 CYS A 596

SSBOND 21 CYS A 612 CYS A 600

SSBOND 22 CYS A 446 CYS A 475

SSBOND 23 CYS A 482 CYS A 491

SSBOND 24 CYS A 199 CYS A 191

SSBOND 25 CYS C 88 CYS C 23

SSBOND 26 CYS C 194 CYS C 134

SSBOND 27 CYS D 95 CYS D 22

SSBOND 28 CYS D 202 CYS D 146

MODRES NAG E 321 NAG-b-D RENAME

MODRES NAG E 322 NAG-b-D RENAME

MODRES MAN E 323 MAN-b-D RENAME

MODRES MAN E 324 MAN-b-D RENAME

MODRES NAG E 3281 NAG-b-D RENAME

MODRES NAG E 3282 NAG-b-D RENAME

MODRES MAN E 3283 MAN-b-D RENAME

MODRES MAN E 3284 MAN-b-D RENAME

MODRES MAN E 3287 MAN-a-D RENAME

MODRES MAN E 3288 MAN-b-D RENAME

MODRES MAN E 3285 MAN-a-D RENAME

MODRES MAN E 3286 MAN-b-D RENAME

MODRES MAN E 3289 MAN-a-D RENAME

MODRES NAG E 3371 NAG-b-D RENAME

MODRES NAG E 3372 NAG-a-D RENAME

MODRES MAN E 3373 MAN-a-D RENAME

MODRES MAN E 3374 MAN-b-D RENAME

MODRES NAG E 3891 NAG-b-D RENAME

MODRES NAG E 3892 NAG-b-D RENAME

MODRES NAG E 4201 NAG-b-D RENAME

MODRES NAG E 4202 NAG-a-D RENAME

MODRES MAN E 4203 MAN-a-D RENAME

MODRES NAG E 5041 NAG-b-D RENAME

MODRES NAG E 5441 NAG-b-D RENAME

MODRES NAG E 5791 NAG-b-D RENAME

MODRES NAG E 881 NAG-b-D RENAME

CRYSTl 77 .823 70.861 147.122 90.00 102 .48 90.00 P 1 21 1

SCALEl 0.012850 0 .000000 0.002844 0.00000 SCALE2 0.000000 0.014112 0.000000 0.00000

SCALE3 0. 000000 0. 000000 0.006962 0.00000

ATOM 1 N LEU A 1 13.360 2.249 11.251 1.00100.92 N

ATOM 3 CA LEU A 1 12.773 1.470 12.398 1.00105.53 C

ATOM 5 CB LEU A 1 11.965 0.248 11.865 1.00108.08 C

ATOM 8 CG LEU A 1 10.656 -0.207 12.561 1.00114.07 C

ATOM 10 CDl LEU A 1 9.579 0.912 12.805 1.00118.27 C

ATOM 14 CD2 LEU A 1 10.023 -1.358 11.772 1.00115.39 C

ATOM 18 C LEU A 1 13.923 1.032 13.354 1.00103.08 C

ATOM 19 O LEU A 1 13.913 1.330 14.572 1.00105.39 O

ATOM 22 N GLU A 2 14.904 0.333 12.772 1.00 98.75 N

ATOM 24 CA GLU A 2 16.143 -0.038 13.449 1.00 95.06 C

ATOM 26 CB GLU A 2 16.981 -0.917 12.518 1.00 90.85 C

ATOM 29 CG GLU A 2 18.025 -1.714 13.253 1.00 89.57 C

ATOM 32 CD GLU A 2 19.160 -2.205 12.358 1.00 88.28 C

ATOM 33 OEl GLU A 2 19.720 -1.403 11.495 1.00 84.21 O

ATOM 34 OE2 GLU A 2 19.493 -3.427 12.562 1.00 89.66 O

ATOM 35 C GLU A 2 16.965 1.207 13.819 1.00 92.58 C

ATOM 36 O GLU A 2 17.201 2.090 12.955 1.00 90.00 O

ATOM 37 N GLU A 3 17.396 1.261 15.096 1.00 93.29 N

ATOM 39 CA GLU A 3 18.416 2.250 15.593 1.00 90.23 C

ATOM 41 CB GLU A 3 18.082 2.630 17.081 1.00 94.21 C

ATOM 44 CG GLU A 3 16.599 3.021 17.380 1.00100.00 C

ATOM 47 CD GLU A 3 16.165 2.910 18.872 1.00105.60 C

ATOM 48 OEl GLU A 3 16.983 2.478 19.722 1.00104.83 O

ATOM 49 OE2 GLU A 3 14.991 3.253 19.229 1.00109.98 O

ATOM 50 C GLU A 3 19.925 1.714 15.412 1.00 84.70 C

ATOM 51 O GLU A 3 20.405 0.936 16.274 1.00 85.80 O

ATOM 52 N LYS A 4 20.618 2.086 14.305 1.00 79.39 N

ATOM 54 CA LYS A 4 21.994 1.608 13.949 1.00 74.36 C

ATOM 56 CB LYS A 4 22.472 2.211 12.626 1.00 70.99 C

ATOM 59 CG LYS A 4 21.654 1.834 11.436 1.00 73.21 C

ATOM 62 CD LYS A 4 22.526 1.263 10.289 1.00 71.25 C

ATOM 65 CE LYS A 4 21.667 0.401 9.254 1.00 75.31 C

ATOM 68 NZ LYS A 4 21.491 1.128 7.883 1.00 76.46 N

ATOM 72 C LYS A 4 23.090 2.043 14.898 1.00 72.83 C

ATOM 73 O LYS A 4 23.169 3.249 15.216 1.00 73.52 O

ATOM 74 N LYS A 5 24.009 1.129 15.248 1.00 70.16 N

ATOM 76 CA LYS A 5 24.974 1.410 16.328 1.00 68.70 C

ATOM 78 CB LYS A 5 25.338 0.124 17.092 1.00 69.57 C

ATOM 81 CG LYS A 5 24.052 -0.768 17.413 1.00 75.20 C

ATOM 84 CD LYS A 5 23.641 -0.893 18.917 1.00 79.29 C

ATOM 87 CE LYS A 5 22.196 -0.390 19.171 1.00 83.67 C

ATOM 90 NZ LYS A 5 21.488 -1.198 20.194 1.00 91.94 N

ATOM 94 C LYS A 5 26.206 2.153 15.828 1.00 64.30 C

ATOM 95 O LYS A 5 26.682 1.926 14.749 1.00 61.85 O

ATOM 96 N VAL A 6 26.724 3.047 16.647 1.00 64.34 N

ATOM 98 CA VAL A 6 27.596 4.114 16.203 1.00 61.78 C

ATOM 100 CB VAL A 6 26.890 5.440 16.468 1.00 63.52 C

ATOM 102 CGl VAL A 6 27.642 6.564 15.784 1.00 61.56 C

ATOM 106 CG2 VAL A 6 25.473 5.382 15.997 1.00 66.36 C

ATOM 110 C VAL A 6 28.801 4.255 17.058 1.00 61.00 C

ATOM 111 O VAL A 6 28.640 4.254 18.203 1.00 63.87 O

ATOM 112 N CYS A 7 29.982 4.525 16.546 1.00 58.45 N

ATOM 114 CA CYS A 7 31.094 4.807 17.432 1.00 59.36 C

ATOM 116 CB CYS A 7 31.943 3.561 17.567 1.00 57.65 C

ATOM 119 SG CYS A 7 32.512 2.903 16.006 1.00 58.73 S

ATOM 120 C CYS A 7 31.926 5.983 16.972 1.00 58.39 C

ATOM 121 O CYS A 7 31.955 6.264 15.829 1.00 57.51 O

ATOM 122 N GLN A 8 32.585 6.702 17.874 1.00 61.38 N

ATOM 124 CA GLN A 8 33.635 7.683 17.502 1.00 61.54 C

ATOM 126 CB GLN A 8 34.054 8.482 18.741 1.00 63.20 C

ATOM 129 CG GLN A 8 32.927 9.373 19.254 1.00 67.39 C

ATOM 132 CD GLN A 8 32.574 10.563 18.334 1.00 70.24 C

ATOM 133 OEl GLN A 8 33.273 10.818 17.335 1.00 70.24 O

ATOM 134 NE2 GLN A 8 31.479 11.300 18.673 1.00 75.33 N

ATOM 137 C GLN A 8 34.857 6.935 16.978 1.00 60.56 C

ATOM 138 O GLN A 8 35.205 5.857 17.449 1.00 63.77 O ATOM 139 N GLY A 9 35.579 7.394 16.026 1.00 58.91 N

ATOM 141 CA GLY A 9 36.720 6.527 15.726 1.00 57.92 C

ATOM 144 C GLY A 9 38.036 7.249 15.990 1.00 60.20 C

ATOM 145 O GLY A 9 38.259 8.517 15.590 1.00 64.00 O

ATOM 146 N THR A 10 38.926 6.543 16.652 1.00 59.60 N

ATOM 148 CA THR A 10 40.369 6.891 16.558 00 60.20 C

ATOM 150 CB THR A 10 41.078 5.669 16.340 1.00 59.09 C

ATOM 152 OGl THR A 10 40.256 4.658 16.885 1.00 66.90 O

ATOM 154 CG2 THR A 10 42.281 5.634 17.296 1.00 61.60 C

ATOM 158 C THR A 10 40.998 7.884 15.538 1.00 57.46 C

ATOM 159 O THR A 10 40.657 7.865 14.372 1.00 55.26 O

ATOM 160 N SER A 11 41.945 8.692 16.037 1.00 57.21 N

ATOM 162 CA SER A 11 42.838 9.479 15.220 1.00 56.01 C

ATOM 164 CB SER A 11 42.438 10.930 15.303 1.00 58.10 C

ATOM 167 OG SER A 11 41.073 11.006 15.003 1.00 58.88 O

ATOM 169 C SER A 11 44.237 9.330 15.720 1.00 56.12 C

ATOM 170 O SER A 11 44.916 10.266 16.008 1.00 56.39 O

ATOM 171 N ASN A 12 44.687 8.118 15.834 1.00 55.44 N

ATOM 173 CA ASN A 12 46.051 7.926 16.295 1.00 58.03 C

ATOM 175 CB ASN A 12 46.089 6.865 17.413 1.00 58.48 C

ATOM 178 CG ASN A 12 44.886 6.955 18.346 1.00 59.19 C

ATOM 179 ODl ASN A 12 44.347 8.062 18.563 1.00 59.90 O

ATOM 180 ND2 ASN A 12 44.426 5.784 18.880 1.00 56.12 N

ATOM 183 C ASN A 12 47.084 7.624 15.172 1.00 57.48 C

ATOM 184 O ASN A 12 48.285 7.497 15.459 1.00 60.22 O

ATOM 185 N LYS A 13 46.655 7.497 13.923 1.00 54.67 N

ATOM 187 CA LYS A 13 47.614 7.192 12.876 1.00 55.14 C

ATOM 189 CB LYS A 13 48.381 8.476 12.501 1.00 57.96 C

ATOM 192 CG LYS A 13 47.420 9.634 12.179 1.00 57.91 C

ATOM 195 CD LYS A 13 48.048 10.642 11.298 1.00 60.41 C

ATOM 198 CE LYS A 13 47.075 11.808 10.983 1.00 63.26 C

ATOM 201 NZ LYS A 13 47.797 13.059 10.472 1.00 67.44 N

ATOM 205 C LYS A 13 48.582 6.093 13.297 1.00 56.16 C

ATOM 206 O LYS A 13 48.171 4.995 13.766 1.00 56.29 O

ATOM 207 N LEU A 14 49.880 6.360 13.196 1.00 57.76 N

ATOM 209 CA LEU A 14 50.813 5.266 13.406 1.00 57.81 C

ATOM 211 CB LEU A 14 51.985 5.375 12.424 1.00 58.72 C

ATOM 214 CG LEU A 14 51.524 5.396 10.955 1.00 56.05 C

ATOM 216 CDl LEU A 14 52.683 5.353 9.975 1.00 57.66 C

ATOM 220 CD2 LEU A 14 50.536 4.287 10.645 1.00 53.10 C

ATOM 224 C LEU A 14 51.243 5.154 14.855 1.00 60.01 C

ATOM 225 O LEU A 14 52.038 4. .261 15.187 1.00 61.31 O

ATOM 226 N THR A 15 50.731 6..037 15.716 1.00 60.49 N

ATOM 228 CA THR A 15 50.925 5..854 17.142 1.00 63.51 C

ATOM 230 CB THR A 15 50.300 6.950 17.944 1.00 64.28 C

ATOM 232 OGl THR A 15 50.825 8.199 17.543 1.00 65.35 O

ATOM 234 CG2 THR A 15 50.791 6.867 19.429 1.00 69.05 C

ATOM 238 C THR A 15 50.397 4.495 17.648 1.00 63.38 C

ATOM 239 O THR A 15 49.322 4.011 17.232 1.00 61.95 O

ATOM 240 N GLN A 16 51.190 3.874 18.517 1.00 66.09 N

ATOM 242 CA GLN A 16 50.868 2.561 19.107 1.00 66.17 C

ATOM 244 CB GLN A 16 52.007 1.560 18.862 1.00 67.19 C

ATOM 247 CG GLN A 16 51.728 0.217 19.455 1.00 66.47 C

ATOM 250 CD GLN A 16 52.838 -0.766 19.295 1.00 66.59 C

ATOM 251 OEl GLN A 16 53.535 -0.791 18.274 1.00 64.81 O

ATOM 252 NE2 GLN A 16 52.984 -1.624 20.293 1.00 68.23 N

ATOM 255 C GLN A 16 50.617 2.737 20.632 1.00 69.21 C

ATOM 256 O GLN A 16 51.390 3.422 21.325 1.00 73.28 O

ATOM 257 N LEU A 17 49.533 2.144 21.148 1.00 67.72 N

ATOM 259 CA LEU A 17 49.033 2.455 22.486 1.00 69.49 C

ATOM 261 CB LEU A 17 47.504 2.620 22.478 1.00 67.31 C

ATOM 264 CG LEU A 17 46.923 3.591 21.437 1.00 64.82 C

ATOM 266 CDl LEU A 17 45.375 3.565 21.397 1.00 62.29 C

ATOM 270 CD2 LEU A 17 47.487 5.032 21.639 1.00 66.62 C

ATOM 274 C LEU A 17 49.450 1.295 23.363 1.00 71.74 C

ATOM 275 O LEU A 17 48.609 0.497 23.794 1.00 71.04 O

ATOM 276 N GLY A 18 50.764 1.193 23.572 1.00 73.66 N

ATOM 278 CA GLY A 18 51.329 0.265 24.520 1.00 76.87 C ATOM 281 C GLY A 18 51.609 -1.038 23.830 1.00 75.65 C

ATOM 282 O GLY A 18 51.968 -1.022 22.636 1.00 72.82 O

ATOM 283 N THR A 19 51.451 -2.140 24.593 1.00 77.55 N

ATOM 285 CA THR A 19 51.581 -3.516 24.099 1.00 76.35 C

ATOM 287 CB THR A 19 51.171 -4.562 25.154 1.00 79.33 C

ATOM 289 OGl THR A 19 51.943 -4.422 26.343 1.00 83.29 O

ATOM 291 CG2 THR A 19 51.574 -5.993 24.734 1.00 82.13 C

ATOM 295 C THR A 19 50.703 -3.715 22.916 1.00 71.66 C

ATOM 296 O THR A 19 49.617 -3.221 22.854 1.00 69.09 O

ATOM 297 N PHE A 20 51.211 -4.445 21.952 1.00 71.13 N

ATOM 299 CA PHE A 20 50.404 -4.916 20.873 1.00 68.02 C

ATOM 301 CB PHE A 20 51.089 -6.099 20.219 1.00 69.47 C

ATOM 304 CG PHE A 20 52.300 -5.752 19.353 1.00 70.89 C

ATOM 305 CDl PHE A 20 53.413 -6.599 19.350 1.00 74.82 C

ATOM 307 CEl PHE A 20 54.500 -6.334 18.562 1.00 76.46 C

ATOM 309 CZ PHE A 20 54.491 -5.207 17.726 1.00 74.93 C

ATOM 311 CE2 PHE A 20 53.391 -4.360 17.707 1.00 69.96 C

ATOM 313 CD2 PHE A 20 52.303 -4.641 18.517 1.00 69.30 C

ATOM 315 C PHE A 20 49.083 -5.409 21.417 1.00 67.44 C

ATOM 316 O PHE A 20 48.034 -5. .063 20.903 1.00 63.96 O

ATOM 317 N GLϋ A 21 49.124 -6.245 22.449 1.00 71.20 N

ATOM 319 CA GLϋ A 21 47.872 -6.628 23.125 1.00 71.94 C

ATOM 321 CB GLU A 21 48.020 -7.643 24.239 1.00 75.53 C

ATOM 324 CG GLU A 21 46.614 -8.017 24.681 1.00 77.19 C

ATOM 327 CD GLU A 21 46.443 -9.456 25.095 1.00 84.24 C

ATOM 328 OEl GLU A 21 46.760 -9.761 26.300 1.00 86.94 O

ATOM 329 OE2 GLU A 21 45.962 -10.251 24.217 1.00 85.07 O

ATOM 330 C GLU A 21 47.004 -5.473 23.632 1.00 71.25 C

ATOM 331 O GLU A 21 45.855 -5.383 23.189 1.00 69.23 O

ATOM 332 N ASP A 22 47.496 -4.605 24.525 1.00 73.11 N

ATOM 334 CA ASP A 22 46.671 -3.422 24.914 1.00 72.68 C

ATOM 336 CB ASP A 22 47.456 -2.386 25.699 1.00 75.14 C

ATOM 339 CG ASP A 22 48.062 -2.919 26.931 1.00 79.93 C

ATOM 340 ODl ASP A 22 47.490 -3.833 27.552 1.00 82.29 O

ATOM 341 OD2 ASP A 22 49.142 -2.460 27.345 1.00 83.24 O

ATOM 342 C ASP A 22 46.054 -2.652 23.717 1.00 68.07 C

ATOM 343 O ASP A 22 44.945 -2.133 23.790 1.00 67.64 O

ATOM 344 N HIS A 23 46.807 -2.553 22.638 1.00 65.04 N

ATOM 346 CA HIS A 23 46.409 -1.772 21.532 1.00 61.33 C

ATOM 348 CB HIS A 23 47.586 -1.723 20.576 1.00 60.16 C

ATOM 351 CG HIS A 23 47.430 -0.802 19.398 1.00 57.41 C

ATOM 352 NDl HIS A 23 47.673 0.552 19.463 1.00 58.45 N

ATOM 354 CEl HIS A 23 47.519 1.098 18.275 1.00 53.82 C

ATOM 356 NE2 HIS A 23 47.197 0.141 17.433 1.00 55.61 N

ATOM 358 CD2 HIS A 23 47.171 -1.062 18.100 1.00 54.92 C

ATOM 360 C HIS A 23 45.178 -2.497 21.012 1.00 59.61 C

ATOM 361 O HIS A 23 44.118 -1.917 20.865 1.00 59.40 O

ATOM 362 N PHE A 24 45.286 -3.789 20.800 1.00 59.94 N

ATOM 364 CA PHE A 24 44.165 -4.543 20.272 1.00 58.09 C

ATOM 366 CB PHE A 24 44.597 -5.974 19.965 1.00 58.40 C

ATOM 369 CG PHE A 24 43.471 -6.884 19.627 1.00 56.74 C

ATOM 370 CDl PHE A 24 43.023 -6.988 18.340 1.00 54.72 C

ATOM 372 CEl PHE A 24 41.961 -7.863 18.065 1.00 55.93 C

ATOM 374 CZ PHE A 24 41.358 614 19.113 1.00 55.91 C

ATOM 376 CE2 PHE A 24 41.803 486 20.339 1.00 56.90 C

ATOM 378 CD2 PHE A 24 42.844 -7 634 20.609 1.00 56.82 C

ATOM 380 C PHE A 24 42.939 -4.503 21.203 1.00 59.52 C

ATOM 381 O PHE A 24 41.843 -4.307 20.754 1.00 58.02 O

ATOM 382 N LEU A 25 43.108 -4, 645 22.501 1.00 63.07 N

ATOM 384 CA LEU A 25 41.933 -4.666 23.381 1.00 65.30 C

ATOM 386 CB LEU A 25 42.314 -4.821 24.840 1.00 68.45 C

ATOM 389 CG LEU A 25 43.082 -6.114 25.072 1.00 72.33 C

ATOM 391 CDl LEU A 25 43.607 -6.190 26.513 1.00 78.48 C

ATOM 395 CD2 LEU A 25 42.279 -7 433 24.705 1.00 72.81 C

ATOM 399 C LEU A 25 41.117 -3 401 23.190 1.00 64.01 C

ATOM 400 O LEU A 25 39.876 -3 424 23.279 1.00 63.70 O

ATOM 401 N SER A 26 41.826 -2.309 22.885 1.00 63.31 N

ATOM 403 CA SER A 26 41.237 -0.975 22.871 1.00 63.14 C ATOM 405 CB SER A 26 42.233 0 . 064 23.416 1.00 64.86 C

ATOM 408 OG SER A 26 42.684 0 . 916 22.406 1.00 65.68 O

ATOM 410 C SER A 26 40.693 ^■0 . 634 21.502 1.00 59.23 C

ATOM 411 O SER A 26 39.666 0. 067 21.392 1.00 58.89 O

ATOM 412 N LEO A 27 41.375 •1. 155 20.478 1.00 56.73 N

ATOM 414 CA LEU A 27 40.789 -1 286 19.177 1.00 53.81 C

ATOM 416 CB LEU A 27 41.575 ■2 .211 18.289 1.00 52.35 C

ATOM 419 CG LEU A 27 41.132 •2 . 136 16.819 1.00 49.44 C

ATOM 421 CDl LEU A 27 41.376 •0 . 797 16.298 1.00 46.75 C

ATOM 425 CD2 LEU A 27 41.881 -3 150 15.889 1.00 49.11 C

ATOM 429 C LEU A 27 39.461 -1 . 911 19.358 1.00 54.56 C

ATOM 430 O LEU A 27 38.466 -1 . 407 18.837 1.00 55.41 O

ATOM 431 N GLN A 28 39.456 -3 . 009 20.096 1.00 55.62 N

ATOM 433 CA GLN A 28 38.281 -3 . 800 20.297 1.00 56.39 C

ATOM 435 CB GLN A 28 38.618 -5 . 091 21.063 1.00 59.09 C

ATOM 438 CG GLN A 28 37.773 ^■6. 291 20.641 1.00 60.00 C

ATOM 441 CD GLN A 28 38.007 •7 . 567 21.488 1.00 64.33 C

ATOM 442 OEl GLN A 28 38.723 ^■7 . 563 22.480 1.00 64.48 O

ATOM 443 NE2 GLN A 28 37.405 8 . 649 21.059 1.00 65.54 N

ATOM 446 C GLN A 28 37.210 -3 034 21.026 1.00 57.59 C

ATOM 447 O GLN A 28 36.029 ^■3 . 157 20.656 1.00 57.19 O

ATOM 448 N ARG A 29 37.594 •2 . 271 22.063 1.00 59.69 N

ATOM 450 CA ARG A 29 36.584 ^■1 . 653 22.971 1.00 62.22 C

ATOM 452 CB ARG A 29 37.133 ^■1 . 079 24.311 1.00 64.71 C

ATOM 461 C ARG A 29 35.845 0 . 627 22.145 1.00 60.09 C

ATOM 462 O ARG A 29 34.649 ^■0 . 509 22.287 1.00 61.92 O

ATOM 463 N MET A 30 36.547 0 . 031 21.226 1.00 57.09 N

ATOM 465 CA MET A 30 35.975 1 . 057 20.390 1.00 55.26 C

ATOM 467 CB MET A 30 37.106 1 . 794 19.716 1.00 53.16 C

ATOM 470 CG MET A 30 36.722 2 . 870 18.699 1.00 51.84 C

ATOM 473 SD MET A 30 35.550 4 . 071 19.326 1.00 54.54 S

ATOM 474 CE MET A 30 36.573 5 . 055 20.420 1.00 55.60 C

ATOM 478 C MET A 30 35.059 0 . 480 19.332 1.00 53.92 C

ATOM 479 O MET A 30 33.907 0 . 863 19.200 1.00 55.74 O

ATOM 480 N PHE A 31 35.550 ^■0 . 468 18.559 1.00 52.04 N

ATOM 482 CA PHE A 31 34.781 •0 . 943 17.430 1.00 49.68 C

ATOM 484 CB PHE A 31 35.756 ■1 . 193 16.273 1.00 47.66 C

ATOM 487 CG PHE A 31 36.433 0 . 085 15.783 1.00 46.71 C

ATOM 488 CDl PHE A 31 37.781 0. 305 15.979 1.00 46.45 C

ATOM 490 CEl PHE A 31 38.321 1 . 541 15.566 1.00 47.62 C

ATOM 492 CZ PHE A 31 37.509 2 . 502 14.959 1.00 44.30 C

ATOM 494 CE2 PHE A 31 36.194 2 . 278 14.788 1.00 42.28 C

ATOM 496 CD2 PHE A 31 35.663 1.104 15.190 1.00 44.72 C

ATOM 498 C PHE A 31 33.789 -2 089 17.673 1.00 50.47 C

ATOM 499 O PHE A 31 33.081 -2.417 16.777 1.00 48.38 O

ATOM 500 N ASN A 32 33.613 -2.585 18.890 1.00 53.44 N

ATOM 502 CA ASN A 32 32.885 -3.794 19.024 1.00 56.24 C

ATOM 504 CB ASN A 32 32.747 -4.260 20.430 1.00 59.73 C

ATOM 507 CG ASN A 32 32.163 -5.711 20.520 1.00 62.37 C

ATOM 508 ODl ASN A 32 32.440 -6.605 19.743 1.00 58.57 O

ATOM 509 ND2 ASN A 32 31.353 -5.911 21.504 1.00 72.53 N

ATOM 512 C ASN A 32 31.558 -3.958 18.295 1.00 58.05 C

ATOM 513 O ASN A 32 31.416 -4.866 17.436 1.00 59.26 O

ATOM 514 N ASN A 33 30.525 -3.217 18.586 1.00 60.46 N

ATOM 516 CA ASN A 33 29.286 -3.562 17.838 1.00 61.41 C

ATOM 518 CB ASN A 33 28.089 -3.573 18.789 1.00 65.21 C

ATOM 521 CG ASN A 33 28.127 -4.776 19.664 1.00 67.90 C

ATOM 522 ODl ASN A 33 28.491 -5.890 19.232 1.00 63.09 O

ATOM 523 ND2 ASN A 33 27.793 -4.578 20.898 1.00 73.36 N

ATOM 526 C ASN A 33 29.053 -2.692 16.659 1.00 59.01 C

ATOM 527 O ASN A 33 27.930 -2.561 16.195 1.00 60.95 O

ATOM 528 N CYS A 34 30.114 -2.094 16.167 1.00 55.98 N

ATOM 530 CA CYS A 34 29.963 -0.850 15.449 1.00 55.77 C

ATOM 532 CB CYS A 34 31.281 -0.106 15.502 1.00 54.43 C

ATOM 535 SG CYS A 34 31.232 1.564 14.851 1.00 57.88 S

ATOM 536 C CYS A 34 29.476 -0.995 13.995 1.00 54.12 C

ATOM 537 O CYS A 34 30.046 -1.728 13.154 1.00 52.55 O

ATOM 538 N GLU A 35 28.408 -0.279 13.701 1.00 54.92 N ATOM 540 CA GLU A 35 27.854 -0.268 12.353 1.00 54.01 C

ATOM 542 CB GLU A 35 26.296 -0.439 12.423 1.00 57.63 C

ATOM 545 CG GLU A 35 25.807 -1.904 12.595 1.00 60.04 C

ATOM 548 CD GLU A 35 24.265 -2.089 12.755 1.00 66.48 C

ATOM 549 OEl GLU A 35 23.430 -1.283 12.291 1.00 69.81 O

ATOM 550 OE2 GLU A 35 23.846 -3.086 13.360 1.00 69.46 O

ATOM 551 C GLU A 35 28.366 0.985 11.531 1.00 50.84 C

ATOM 552 O GLU A 35 28.835 0.861 10.394 1.00 47.39 O

ATOM 553 N VAL A 36 28.298 2.154 12.164 1.00 51.35 N

ATOM 555 CA VAL A 36 28.759 3..440 11.634 1.00 49.75 C

ATOM 557 CB VAL A 36 27.613 4, .468 11.651 1.00 52.18 C

ATOM 559 CGl VAL A 36 28.075 5..785 11.084 1.00 50.62 C

ATOM 563 CG2 VAL A 36 26.441 3..964 10.857 1.00 53.96 C

ATOM 567 C VAL A 36 29.898 4..062 12.454 1.00 48.86 C

ATOM 568 O VAL A 36 29.810 4.215 13.664 1.00 50.58 O

ATOM 569 N VAL A 37 30.955 4.440 11.786 1.00 46.36 N

ATOM 571 CA VAL A 37 32.030 5.169 12.417 1.00 46.84 C

ATOM 573 CB VAL A 37 33.361 4.637 11.878 1.00 44.64 C

ATOM 575 CGl VAL A 37 34.537 5.214 12.638 1.00 45.69 C

ATOM 579 CG2 VAL A 37 33.372 3.171 11.950 1.00 43.09 C

ATOM 583 C VAL A 37 31.876 6.682 12.091 1.00 47.84 C

ATOM 584 O VAL A 37 32.128 7.150 10.959 1.00 47.48 O

ATOM 585 N LEU A 38 31.406 7.446 13.057 1.00 49.78 N

ATOM 587 CA LEU A 38 31.412 8.917 12.977 1.00 50.77 C

ATOM 589 CB LEU A 38 31.068 9.494 14.341 1.00 53.03 C

ATOM 592 CG LEU A 38 29.739 9.093 14.919 1.00 54.79 C

ATOM 594 CDl LEU A 38 29.401 10.042 16.017 1.00 57.99 C

ATOM 598 CD2 LEU A 38 28.708 9.110 13.851 1.00 54.29 C

ATOM 602 C LEU A 38 32.752 9.540 12.550 1.00 49.42 C

ATOM 603 O LEU A 38 32.748 10.523 11.843 1.00 50.78 O

ATOM 604 N GLY A 39 33.862 8.991 13.049 1.00 48.45 N

ATOM 606 CA GLY A 39 35.219 9.454 12.840 1.00 47.35 C

ATOM 609 C GLY A 39 35.961 8.563 11.878 1.00 45.06 C

ATOM 610 O GLY A 39 35.409 8.141 10.867 1.00 45.58 O

ATOM 611 N ASN A 40 37.225 8.286 12.136 1.00 44.47 N

ATOM 613 CA ASN A 40 37.921 7.385 11.256 1.00 42.80 C

ATOM 615 CB ASN A 40 39.282 7.891 10.781 1.00 43.45 C

ATOM 618 CG ASN A 40 39.429 9.389 10.797 1.00 44.32 C

ATOM 619 ODl ASN A 40 38.929 10.062 9.935 1.00 45.99 O

ATOM 620 ND2 ASN A 40 40.205 9.897 11.734 1.00 44.54 N

ATOM 623 C ASN A 40 38.159 6.049 11.918 1.00 42.57 C

ATOM 624 O ASN A 40 38.211 5.931 13.148 1.00 44.09 O

ATOM 625 N LEU A 41 38.390 5.082 11.046 1.00 40.76 N

ATOM 627 CA LEU A 41 38.610 3.727 11.369 1.00 40.75 C

ATOM 629 CB LEU A 41 37.822 2.850 10.400 1.00 39.36 C

ATOM 632 CG LEU A 41 38.090 1.346 10.561 1.00 40.49 C

ATOM 634 CDl LEU A 41 37.763 0.779 11.990 1.00 44.00 C

ATOM 638 CD2 LEU A 41 37.247 0.567 9.646 1.00 41.86 C

ATOM 642 C LEU A 41 40.058 3.488 11.150 1.00 40.97 C

ATOM 643 O LEU A 41 40.525 3.672 10.045 1.00 41.21 O

ATOM 644 N GLU A 42 40.785 3.046 12.166 1.00 42.33 N

ATOM 646 CA GLU A 42 42.201 2.775 12.003 1.00 42.70 C

ATOM 648 CB GLU A 42 43.020 3.721 12.808 1.00 44.36 C

ATOM 651 CG GLU A 42 42.695 5.159 12.455 1.00 47.91 C

ATOM 654 CD GLU A 42 43.418 6.201 13.308 1.00 51.77 C

ATOM 655 OEl GLU A 42 43.332 6.066 14.581 1.00 51.29 O

ATOM 656 OE2 GLU A 42 44.027 7.154 12.688 1.00 51.12 O

ATOM 657 C GLU A 42 42.486 1.426 12.488 1.00 43.28 C

ATOM 658 O GLU A 42 42.282 1.164 13.667 1.00 45.62 O

ATOM 659 N ILE A 43 42.979 0.557 11.605 1.00 42.12 N

ATOM 661 CA ILE A 43 43.421 -0.746 12.046 1.00 42.21 C

ATOM 663 CB ILE A 43 42.633 -1.771 11.341 1.00 40.74 C

ATOM 665 CGl ILE A 43 41.166 -1.548 11.668 1.00 39.80 C

ATOM 668 ^■ CDl ILE A 43 40.301 -1.940 10.641 1.00 39.39 C

ATOM 672 CG2 ILE A 43 43.052 -3.107 11.840 1.00 43.58 C

ATOM 676 C ILE A 43 44.919 -0.912 11.876 1.00 42.70 C

ATOM 677 O ILE A 43 45.477 -0.694 10.858 1.00 42.81 O

ATOM 678 N THR A 44 45.555 -1.355 12.916 1.00 44.98 N ATOM 680 CA THR A 44 46. 888 -0. 922 13 .235 1. 00 46. 86 C

ATOM 682 CB THR A 44 46.703 0. 473 13.748 1.00 47.31 C

ATOM 684 OGl THR A 44 46. 847 1. 369 12.637 1.00 48.62 O

ATOM 686 CG2 THR A 44 47 . 744 0. 877 14.643 1.00 49.36 C

ATOM 690 C THR A 44 47 . 609 -1.798 14.277 1.00 49.13 C

ATOM 691 O THR A 44 47 .102 -2.055 15.380 1.00 49.25 O

ATOM 692 N TYR A 45 48.794 -2.258 13.899 1.00 50.28 N

ATOM 694 CA TYR A 45 49. 613 -3.069 14.773 1.00 52.93 C

ATOM 696 CB TYR A 45- 50.095 -2.247 15.992 1.00 55.11 C

ATOM 699 CG TYR A 45 50. 992 -1 .106 15.593 1.00 55.23 C

ATOM 700 CDl TYR A 45 50.530 0 .165 15.617 1.00 54.89 C

ATOM 702 CEl TYR A 45 51.299 1.209 15.259 1.00 54.93 C

ATOM 704 CZ TYR A 45 52.553 0. 999 14.808 1.00 56.32 C

ATOM 705 OH TYR A 45 53.273 2. 109 14.459 1.00 62.09 O

ATOM 707 CE2 TYR A 45 53.066 -0.250 14.754 1.00 56.10 C

ATOM 709 CD2 TYR A 45 52.279 -1.306 15.143 1.00 56.61 C

ATOM 711 C TYR A 45 48. 946 -4 .393 15.189 1.00 53.13 C

ATOM 712 O TYR A 45 49.477 -5.102 16.030 1.00 56.05 O

ATOM 713 N VAL A 46 47 . 843 -4.775 14.559 1.00 50.80 N

ATOM 715 CA VAL A 46 47 .215 -6. 039 14.908 1.00 51.76 C

ATOM 717 CB VAL A 46 45. 861 -6.206 14.238 1.00 49.39 C

ATOM 719 CGl VAL A 46 45.204 -7 .480 14.608 1.00 50.02 C

ATOM 723 CG2 VAL A 46 44 . 963 -5. 087 14.699 1.00 51.23 C

ATOM 727 C VAL A 46 48 . 118 -7 .153 14.509 1.00 53.22 C

ATOM 728 O VAL A 46 48.496 -7..203 13.361 1.00 53.23 O

ATOM 729 N GLN A 47 48 . 430 -8.050 15.436 1.00 56.14 N

ATOM 731 CA GLN A 47 49.344 -9.151 15.162 1.00 59.49 C

ATOM 733 CB GLN A 47 50.283 -9.340 16.373 1.00 63.39 C

ATOM 736 CG GLN A 47 51.212 -8.130 16.701 1.00 64.49 C

ATOM 739 CD GLN A 47 52.252 -7.834 15.592 1.00 64.62 C

ATOM 740 OEl GLN A 47 52.947 -8.741 15.096 1.00 64.30 O

ATOM 741 NE2 GLN A 47 52.335 -6.564 15.191 1.00 65.38 N

ATOM 744 C GLN A 47 48.684 -10.517 14.730 1.00 60.25 C

ATOM 745 O GLN A 47 47.461 -10.670 14.710 1.00 59.39 O

ATOM 746 N ARG A 48 49.500 -11.502 14.381 1.00 62.64 N

ATOM 748 CA ARG A 48 48.950 -12.787 13.940 1.00 64.49 C

ATOM 750 CB ARG A 48 50.048 -13.799 13.534 1.00 67.77 C

ATOM 753 CG ARG A 48 50.278 -13.822 12.038 1.00 68.04 C

ATOM 756 CD ARG A 48 51.286 -14.816 11.673 1.00 74.89 C

ATOM 759 NE ARG A 48 50.712 -15.969 10.921 1.00 78.86 N

ATOM 761 CZ ARG A 48 50.734 -17.271 11.322 1.00 76.74 C

ATOM 762 NHl ARG A 48 51.286 -17.691 12.474 1.00 78.50 N

ATOM 765 NH2 ARG A 48 50.196 -18.159 10.526 1.00 78.65 N

ATOM 768 C ARG A 48 48.077 -13.463 14.977 1.00 65.82 C

ATOM 769 O ARG A 48 48.387 -13.433 16.148 1.00 69.06 O

ATOM 770 N ASN A 49 47.020 -14.120 14.508 1.00 64.58 N

ATOM 772 CA ASN A 49 46.070 -14.867 15.340 1.00 65.41 C

ATOM 774 CB ASN A 49 46.724 -16.066 16.015 1.00 69.43 C

ATOM 777 CG ASN A 49 47.310 -16.988 15.043 1.00 70.04 C

ATOM 778 ODl ASN A 49 46.635 -17.426 14.102 1.00 68.58 O

ATOM 779 ND2 ASN A 49 48.587 -17.271 15.207 1.00 73.31 N

ATOM 782 C ASN A 49 45.334 -14.079 16.368 1.00 64.69 C

ATOM 783 O ASN A 49 44.878 -14.646 17.355 1.00 66.94 O

ATOM 784 N TYR A 50 45.214 -12.785 16.166 1.00 61.48 N

ATOM 786 CA TYR A 50 44.278 -12.059 16.973 1.00 62.03 C

ATOM 788 CB TYR A 50 44.795 -10.662 17.261 1.00 61.43 C

ATOM 791 CG TYR A 50 45.768 -10.556 18.432 1.00 64.24 C

ATOM 792 CDl TYR A 50 47.030 -11.118 18.363 1.00 65.32 C

ATOM 794 CEl TYR A 50 47.922 -10.989 19.436 1.00 69.50 C

ATOM 796 CZ TYR A 50 47.553 -10.279 20.561 1.00 70.19 C

ATOM 797 OH TYR A 50 48.425 -10.156 21.594 1.00 74.47 O

ATOM 799 CE2 TYR A 50 46.328 -9.705 20.642 1.00 67.54 C

ATOM 801 CD2 TYR A 50 45.446 -9.818 19.573 1.00 64.01 C

ATOM 803 C TYR A 50 42.992 -11.996 16.156 1.00 59.86 C

ATOM 804 O TYR A 50 43.082 -11.703 15.011 1.00 57.85 O

ATOM 805 N ASP A 51 41.818 -12.223 16.752 1.00 61.02 N

ATOM 807 CA ASP A 51 40.540 -12.225 16.037 1.00 59.60 C

ATOM 809 CB ASP A 51 39.472 -12.905 16.896 1.00 62.57 C ATOM 812 CG ASP A 51 38.272 -13.445 16.079 1.00 61.90 C

ATOM 813 ODl ASP A 51 38.043 -13.027 14.914 1.00 53.66 O

ATOM 814 OD2 ASP A 51 37.498 -14.330 16.570 1.00 65.06 O

ATOM 815 C ASP A 51 40.013 -10.838 15.775 1.00 57.33 C

ATOM 816 O ASP A 51 39.564 -10.219 16.717 1.00 59.76 O

ATOM 817 N LEU A 52 39.985 -10.397 14.519 1.00 54.26 N

ATOM 819 CA LEU A 52 39.331 -9.145 14.121 1.00 52.34 C

ATOM 821 CB LEQ A 52 40.110 -8.415 13.029 1.00 49.67 C

ATOM 824 CG LEU A 52 41.456 -7..893 13.423 1.00 50.34 C

ATOM 826 CDl LEU A 52 42.092 -7..459 12.115 1.00 49.85 C

ATOM 830 CD2 LEU A 52 41.305 -6.728 14.427 1.00 50.52 C

ATOM 834 C LEU A 52 37.948 -9.321 13.542 1.00 51.96 C

ATOM 835 O LEU A 52 37.444 -I .450 12.848 1.00 50.66 O

ATOM 836 N SER A 53 37.293 -10.399 13.864 1.00 54.16 N

ATOM 838 CA SER A 53 36.003 -10.618 13.274 1.00 54.53 C

ATOM 840 CB SER A 53 35.526 -12.042 13.555 1.00 56.90 C

ATOM 843 OG SER A 53 35.460 -12.203 14.922 1.00 58.05 O

ATOM 845 C SER A 53 34.947 -9.619 13.758 1.00 55.01 C

ATOM 846 O SER A 53 33.897 -9.595 13.168 1.00 56.80 O

ATOM 847 N PHE A 54 35.168 -8.820 14.802 1.00 54.98 N

ATOM 849 CA PHE A 54 34.142 -7.845 15.190 1.00 55.18 C

ATOM 851 CB PHE A 54 34.467 -7.156 16.478 1.00 55.26 C

ATOM 854 CG PHE A 54 35.840 -6.619 16.535 1.00 53.23 C

ATOM 855 CDl PHE A 54 36.104 -5.318 16.141 1.00 55.25 C

ATOM 857 CEl PHE A 54 37.420 -4.754 16.207 1.00 53.92 C

ATOM 859 CZ PHE A 54 38.446 -5.524 16.671 1.00 56.11 C

ATOM 861 CE2 PHE A 54 38.166 -6.881 17.085 1.00 54.50 C

ATOM 863 CD2 PHE A 54 36.883 -7.395 16.974 1.00 53.07 C

ATOM 865 C PHE A 54 33.936 -6.763 14.167 1.00 54.02 C

ATOM 866 O PHE A 54 32.946 -6.016 14.274 1.00 56.54 O

ATOM 867 N LEU A 55 34.895 -6.616 13.233 1.00 51.66 N

ATOM 869 CA LEU A 55 34.779 -5.672 12.103 1.00 48.92 C

ATOM 871 CB LEU A 55 36.115 -5.550 11.426 1.00 46.55 C

ATOM 874 CG LEU A 55 37.205 -5.064 12.318 1.00 46.74 C

ATOM 876 CDl LEU A 55 38.490 -5.184 11.621 1.00 45.91 C

ATOM 880 CD2 LEU A 55 36.962 -3.616 12.600 1.00 47.82 C

ATOM 884 C LEU A 55 33.821 -6.095 10.989 1.00 48.78 C

ATOM 885 O LEU A 55 33.656 -5.390 9.989 1.00 49.08 O

ATOM 886 N LYS A 56 33.230 -7.274 11.090 1.00 50.51 N

ATOM 888 CA LYS A 56 32.248 -7. , 667 10.096 1.00 50.35 C

ATOM 890 CB LYS A 56 31.836 -9.114 10.238 1.00 52.48 C

ATOM 893 CG LYS A 56 32.973 -10.132 10.110 1.00 53.73 C

ATOM 896 CD LYS A 56 32.484 -11.607 9.798 1.00 58.55 C

ATOM 899 CE LYS A 56 33.628 -12.680 9.390 1.00 59.21 C

ATOM 902 NZ LYS A 56 33.071 -13.963 8.832 1.00 61.23 N

ATOM 906 C LYS A 56 31.048 -6.741 10.221 1.00 50.84 C

ATOM 907 O LYS A 56 30.296 -6.625 9.287 1.00 51.82 O

ATOM 908 N THR A 57 30.905 -6.036 11.339 1.00 51.04 N

ATOM 910 CA THR A 57 29.736 -5.205 11.583 1.00 52.25 C

ATOM 912 CB THR A 57 29.699 -4.985 13.031 1.00 53.38 C

ATOM 914 OGl THR A 57 29.273 -6.173 13.594 1.00 54.50 O

ATOM 916 CG2 THR A 57 28.567 -4.211 13.417 1.00 58.64 C

ATOM 920 C THR A 57 29.757 -3.823 10.876 1.00 50.73 C

ATOM 921 O THR A 57 28.726 -3.142 10.690 1.00 50.93 O

ATOM 922 N ILE A 58 30.947 -3.412 10.510 1.00 48.03 N

ATOM 924 CA ILE A 58 31.102 -2.105 10.062 1.00 47.21 C

ATOM 926 CB ILE A 58 32.545 -1..755 10.092 1.00 45.62 C

ATOM 928 CGl ILE A 58 32.947 ,611 11.543 1.00 47.30 C

ATOM 931 CDl ILE A 58 34.411 -1.176 11.687 1.00 48.07 C

ATOM 935 CG2 ILE A 58 32.779 -0.361 9.424 1.00 45.43 C

ATOM 939 C ILE A 58 30.472 -1.946 8.683 1.00 46.76 C

ATOM 940 O ILE A 58 30.884 -2.571 7.729 1.00 46.94 O

ATOM 941 N GLN A 59 29.457 -1.091 8.633 1.00 47.32 N

ATOM 943 CA GLN A 59 28.765 -0.744 7.433 1.00 46.32 C

ATOM 945 CB GLN A 59 27.308 -0.535 7.789 1.00 49.40 C

ATOM 948 CG GLN A 59 26.460 -1. 801 748 1.00 50.88 C

ATOM 951 CD GLN A 59 25.154 -1.630 8.490 1.00 56.62 C

ATOM 952 OEl GLN A 59 24.282 -0.851 8.084 1.00 61.17 O ATOM 953 NE2 GLN A 59 25.029 -2.319 9.621 1.00 62.39 N

ATOM 956 C GLN A 59 29.328 0.491 6.793 1.00 43.74 C

ATOM 957 O GLN A 59 29.321 0.621 5..609 1.00 42.04 O

ATOM 958 N GLU A 60 29.790 1.437 7..575 1.00 43.80 N

ATOM 960 CA GLO A 60 30.199 2.713 6.964 1.00 43.43 C

ATOM 962 CB GLO A 60 28.983 3.525 6.485 1.00 45.57 C

ATOM 965 CG GLO A 60 27.904 3.828 7.486 1.00 49.95 C

ATOM 968 CD GLO A 60 26.781 4.755 6.943 1.00 55.76 C

ATOM 969 OEl GLU A 60 25.747 4.155 6.484 1.00 53.00 O

ATOM 970 OE2 GLU A 60 26.933 6.058 7.002 1.00 55.62 O

ATOM 971 C GLU A 60 31.110 3.560 7.813 1.00 41.36 C

ATOM 972 O GLO A 60 31.060 3.489 8.959 1.00 41.52 O

ATOM 973 N VAL A 61 31.956 4.343 7.171 1.00 40.34 N

ATOM 975 CA VAL A 61 32.955 5.212 7.787 1.00 40.06 C

ATOM 977 CB VAL A 61 34.383 4.620 7.589 1.00 38.27 C

ATOM 979 CGl VAL A 61 35.479 5.597 8.136 1.00 38.94 C

ATOM 983 CG2 VAL A 61 34.453 3.245 8.246 1.00 36.00 C

ATOM 987 C VAL A 61 32.892 6.673 7.263 1.00 41.13 C

ATOM 988 O VAL A 61 33.035 7.009 6.073 1.00 40.36 O

ATOM 989 N ALA A 62 32.717 7.588 8.167 1.00 43.43 N

ATOM 991 CA ALA A 62 32.644 8.993 7.741 1.00 44.23 C

ATOM 993 CB ALA A 62 32.068 9.827 8.844 1.00 45.33 C

ATOM 997 C ALA A 62 34.000 9.548 7.301 1.00 42.41 C

ATOM 998 O ALA A 62 34.058 10.357 6.397 1.00 43.72 O

ATOM 999 N GLY A 63 35.062 9.160 7.984 1.00 41.42 N

ATOM 1001 CA GLY A 63 36.337 9.844 7.875 1.00 41.84 C

ATOM 1004 C GLY A 63 37.229 9.070 6.951 1.00 40.75 C

ATOM 1005 O GLY A 63 36.820 8.695 5.882 1.00 40.21 O

ATOM 1006 N TYR A 64 38.425 8.717 7.359 1.00 40.83 N

ATOM 1008 CA TYR A 64 39.185 7.771 6.561 1.00 39.12 C

ATOM 1010 CB TYR A 64 40.559 8.330 6.344 1.00 40.77 C

ATOM 1013 CG TYR A 64 41.366 8.605 7.595 1.00 40.87 C

ATOM 1014 CDl TYR A 64 42.182 7.617 8.184 1.00 42.70 C

ATOM 1016 CEl TYR A 64 42.969 7.892 9.305 1.00 44.16 C

ATOM 1018 CZ TYR A 64 42.910 9.171 9.833 1.00 42.92 C

ATOM 1019 OH TYR A 64 43.627 9.512 10.935 1.00 43.56 O

ATOM 1021 CE2 TYR A 64 42.090 10.108 9.279 1.00 43.84 C

ATOM 1023 CD2 TYR A 64 41.353 9.838 8.153 1.00 43.12 C

ATOM 1025 C TYR A 64 39.325 6.394 7.210 1.00 39.09 C

ATOM 1026 O TYR A 64 39.007 6.183 8.369 1.00 40.13 O

ATOM 1027 N VAL A 65 39.833 5.469 6.425 1.00 37.79 N

ATOM 1029 CA VAL A 65 40.165 4.157 6.845 1.00 37.58 C

ATOM 1031 CB VAL A 65 39.451 3.155 5.959 1.00 36.44 C

ATOM 1033 CGl VAL A 65 39.941 1.695 6.176 1.00 35.49 C

ATOM 1037 CG2 VAL A 65 38.020 3.234 6.276 1.00 38.10 C

ATOM 1041 C VAL A 65 41.665 4.017 6.681 1.00 38.37 C

ATOM 1042 O VAL A 65 42.169 4.112 5.579 1.00 38.62 O

ATOM 1043 N LEO A 66 42.377 3.760 7.760 1.00 38.89 N

ATOM 1045 CA LEU A 66 43.750 3.428 7.621 1.00 40.32 C

ATOM 1047 CB LEU A 66 44.519 4.432 8.405 1.00 42.88 C

ATOM 1050 CG LEU A 66 45.904 4.043 8.875 1.00 45.09 C

ATOM 1052 CDl LEO A 66 46.821 3.880 7.728 1.00 44.69 C

ATOM 1056 CD2 LEU A 66 46.373 5.153 9.836 1 1..00 48.02 C

ATOM 1060 C LEU A 66 44.042 2.058 8.155 11..00 40.80 C

ATOM 1061 O LEU A 66 43.832 1.757 9.314 1.00 42.77 O

ATOM 1062 N ILE A 67 44.576 1.198 7.326 1.00 40.95 N

ATOM 1064 CA ILE A 67 45.001 -0.132 7.747 1.00 40.61 C

ATOM 1066 CB ILE A 67 44.324 -1.113 6.861 1.00 39.42 C

ATOM 1068 CGl ILE A 67 42.836 -1.076 7.096 1.00 37.05 C

ATOM 1071 CDl ILE A 67 42.129 -1.575 5.966 1.00 36.61 C

ATOM 1075 CG2 ILE A 67 44.845 -2.486 7.132 1.00 42.01 C

ATOM 1079 C ILE A 67 46.526 -0.226 7.596 1.00 42.09 C

ATOM 1080 O ILE A 67 47.035 -0.356 6.481 1.00 42.06 O

ATOM 1081 N ALA A 68 47.252 -0.097 8.693 1.00 43.71 N

ATOM 1083 CA ALA A 68 48.691 -0.174 8.634 1.00 46.04 C

ATOM 1085 CB ALA A 68 49.231 1.175 8.518 1.00 46.74 C

ATOM 1089 C ALA A 68 49.421 -0.962 9.771 1.00 48.21 C

ATOM 1090 O ALA A 68 48.939 -1.126 10.901 1.00 47.90 O ATOM 1091 N LED A 69 50.597 -1.464 9.396 1.00 50.08 N

ATOM 1093 CA LEU A 69 51.542 -2.143 10.292 1.00 52.36 C

ATOM 1095 CB LEO A 69 52.199 -1.127 11.234 1.00 53.98 C

ATOM 1098 CG LEU A 69 52.815 0.105 10.537 1.00 54.54 C

ATOM 1100 CDl LEU A 69 53.048 1.269 11.481 1.00 55.84 C

ATOM 1104 CD2 LEU A 69 54.114 -0.210 9.926 1.00 56.72 C

ATOM 1108 C LEU A 69 50.917 -3.355 10.993 1.00 51.43 C

ATOM 1109 O LEU A 69 51.253 -3.718 12.102 1.00 52.82 O

ATOM 1110 N ASN A 70 50.034 -3. .989 10.254 1.00 49.53 N

ATOM 1112 CA ASN A 70 49.288 -5.146 10.709 1.00 49.78 C

ATOM 1114 CB ASN A 70 47.887 -5.148 10.071 1.00 47.45 C

ATOM 1117 CG ASN A 70 47.025 -4.054 10.557 1.00 45.01 C

ATOM 1118 ODl ASN A 70 46.654 -4.043 11.719 1.00 45.13 O

ATOM 1119 ND2 ASN A 70 46.719 -3.102 9.690 1.00 43.78 N

ATOM 1122 C ASN A 70 49.990 -6.380 10.192 1.00 51.18 C

ATOM 1123 O ASN A 70 50.449 -6.375 9.044 1.00 50.13 O

ATOM 1124 N THR A 71 50.106 -7.425 11.001 1.00 53.00 N

ATOM 1126 CA THR A 71 50.513 -8.709 10.427 1.00 55.45 C

ATOM 1128 CB THR A 71 51.718 -9.356 11.116 1.00 58.70 C

ATOM 1130 OGl THR A 71 51.432 -9.593 12.492 1.00 59.65 O

ATOM 1132 CG2 THR A 71 52.909 -8.463 11.068 1.00 60.02 C

ATOM 1136 C THR A 71 49.382 -9.714 10.440 1.00 55.26 C

ATOM 1137 O THR A 71 49.550 -10.818 9.952 1.00 55.74 O

ATOM 1138 N VAL A 72 48.242 -9.316 11.005 1.00 53.94 N

ATOM 1140 CA VAL A 72 47.114 -10.219 11.120 1.00 53.04 C

ATOM 1142 CB VAL A 72 45.909 -9.515 11.839 1.00 51.69 C

ATOM 1144 CGl VAL A 72 45.385 -8.312 11.059 1.00 47.61 C

ATOM 1148 CG2 VAL A 72 44.786 -10.530 12.214 1.00 51.56 C

ATOM 1152 C VAL A 72 46.800 -10.776 9.727 1.00 51.50 C

ATOM 1153 O VAL A 72 46.932 -10.096 8.734 1.00 50.25 O

ATOM 1154 N GLU A 73 46.456 -12.047 9.672 1.00 53.42 N

ATOM 1156 CA GLU A 73 46.307 -12.720 8.413 1.00 53.56 C

ATOM 1158 CB GLU A 73 46.091 -14.219 8.575 1.00 55.45 C

ATOM 1161 CG GLU A 73 46.005 -14.829 7.190 1.00 57.21 C

ATOM 1164 CD GLU A 73 46.159 -16.328 7.121 1.00 65.02 C

ATOM 1165 OEl GLU A 73 46.539 -16.914 8.248 1.00 68.29 O

ATOM 1166 OE2 GLU A 73 45.894 -16.869 5.933 1.00 62.47 O

ATOM 1167 C GLU A 73 45.169 -12.057 7.647 1.00 51.07 C

ATOM 1168 O GLU A 73 45.351 -11.655 6.539 1.00 49.97 O

ATOM 1169 N ARG A 74 44.011 -11.888 8.257 1.00 50.85 N

ATOM 1171 CA ARG A 74 42.877 -11.303 7.545 1.00 49.00 C

ATOM 1173 CB ARG A 74 41.874 -12.437 7.294 1.00 49.93 C

ATOM 1176 CG ARG A 74 40.411 -12.118 7.396 1 1..0000 51.98 C

ATOM 1179 CD ARG A 74 39.468 -13.326 7.038 1.00 54.93 C

ATOM 1182 NE ARG A 74 39.084 -13.105 5.645 1.00 59.31 N

ATOM 1184 CZ ARG A 74 38.269 -13.895 4.959 1.00 62.52 C

ATOM 1185 NHl ARG A 74 37.762 -14.941 5.616 1.00 65.45 N

ATOM 1188 NH2 ARG A 74 37.967 -13.648 3.635 1.00 58.43 N

ATOM 1191 C ARG A 74 42.266 -10.058 8.264 1.00 46.63 C

ATOM 1192 O ARG A 74 42.386 -9.919 9.436 1.00 46.29 O

ATOM 1193 N ILE A 75 41.684 -9.133 7.517 1.00 44.98 N

ATOM 1195 CA ILE A 75 40.955 -7.991 8.086 1.00 43.65 C

ATOM 1197 CB ILE A 75 41.725 -6.736 7.884 1.00 42.04 C

ATOM 1199 CGl ILE A 75 42.831 -6. .684 8.929 1.00 43.21 C

ATOM 1202 CDl ILE A 75 44.040 -5.756 8.633 1.00 42.89 C

ATOM 1206 CG2 ILE A 75 40.805 -5.538 8.084 1.00 42.87 C

ATOM 1210 C ILE A 75 39.538 -7.913 7.476 1.00 42.35 C

ATOM 1211 O ILE A 75 39.350 -7.353 6.451 1.00 39.45 O

ATOM 1212 N PRO A 76 38.576 -8.592 8.099 1.00 43.86 N

ATOM 1213 CA PRO A 76 37.285 -8.857 7.461 1.00 43.31 C

ATOM 1215 CB PRO A 76 36.796 -10.049 8.210 1.00 43.97 C

ATOM 1218 CG PRO A 76 37.340 -9.772 9.568 1.00 45.76 C

ATOM 1221 CD PRO A 76 38.691 -9.247 9.406 1.00 44.45 C

ATOM 1224 C PRO A 76 36.324 -7.728 7.568 1.00 42.78 C

ATOM 1225 O PRO A 76 35.396 -7.831 8.333 1.00 45.44 O

ATOM 1226 N LEU A 77 36.535 -6.697 6.748 1.00 41.49 N

ATOM 1228 CA LEU A 77 35.641 -5.567 6.537 1.00 39.87 C

ATOM 1230 CB LEU A 77 36.546 -4.409 6.198 1.00 38.77 C ATOM 1233 CG LEU A 77 37.158 -3.827 7.512 1.00 41.18 C

ATOM 1235 CDl LEU A 77 38.215 -2.809 7.271 1.00 41.61 C

ATOM 1239 CD2 LEU A 77 36.111 -3.156 8.502 1.00 40.56 C

ATOM 1243 C LEU A 77 34.637 -5.929 5.427 1.00 41.28 C

ATOM 1244 O LEU A 77 34.447 -5.251 4.413 1.00 42.53 O

ATOM 1245 N GLU A 78 33.972 -7.055 5.647 1.00 43.65 N

ATOM 1247 CA GLU A 78 33.051 -7.679 4.726 1.00 44.72 C

ATOM 1249 CB GLU A 78 32.625 -9.074 5.243 1.00 47.90 C

ATOM 1252 CG GLU A 78 33.638 -10.261 5.125 1.00 49.04 C

ATOM 1255 CD GLU A 78 33.290 -11.463 6.010 1.00 57.37 C

ATOM 1256 OEl GLU A 78 32.198 -11.438 6.698 1.00 60.60 O

ATOM 1257 OE2 GLU A 78 34.099 -12.458 6.053 1.00 64.67 O

ATOM 1258 C GLU A 78 31.804 -6.852 4.471 1.00 45.32 C

ATOM 1259 O GLU A 78 31.180 -7.118 3.483 1.00 48.23 O

ATOM 1260 N ASN A 79 31.427 -5.864 5.300 1.00 45.00 N

ATOM 1262 CA ASN A 79 30.167 -5.128 5.064 1.00 45.06 C

ATOM 1264 CB ASN A 79 29.175 -5.520 6.123 1.00 47.94 C

ATOM 1267 CG ASN A 79 28.893 -7.032 6.112 1.00 46.44 C

ATOM 1268 ODl ASN A 79 28.282 -7.536 5.190 1.00 48.09 O

ATOM 1269 ND2 ASN A 79 29.350 -7.723 7.101 1.00 45.47 N

ATOM 1272 C ASN A 79 30.263 -3.572 4.936 1.00^x44.03 C

ATOM 1273 O ASN A 79 29.243 -2. .882 4.734 1.00 44.31 O

ATOM 1274 N LEU A 80 31.505 -3, .086 4.968 1.00 41.14 N

ATOM 1276 CA LEU A 80 31.853 .726 4.783 1.00 39.81 C

ATOM 1278 CB LEU A 80 33.381 -1.607 4.910 1.00 35.95 C

ATOM 1281 CG LEU A 80 33.900 -0.184 4.736 1.00 39.21 C

ATOM 1283 CDl LEU A 80 33.164 0.825 5.606 1.00 37.81 C

ATOM 1287 CD2 LEU A 80 35.397 0.048 4.966 1.00 41.93 C

ATOM 1291 C LEU A 80 31.377 -1..250 3.421 1.00 40.93 C

ATOM 1292 O LEU A 80 32.049 -1..496 2.469 1.00 42.60 O

ATOM 1293 N GLN A 81 30.255 -0.537 3.300 1.00 42.84 N

ATOM 1295 CA GLN A 81 29.796 -0.098 1.984 1.00 43.93 C

ATOM 1297 CB GLN A 81 28.269 0.058 1.841 1.00 46.43 C

ATOM 1300 CG GLN A 81 27.410 -0.770 2.822 1.00 53.59 C

ATOM 1303 CD GLN A 81 25.871 -0.694 2.613 1.00 59.31 C

ATOM 1304 OEl GLN A 81 25.397 -0.526 1.466 1.00 64.23 O

ATOM 1305 NE2 GLN A 81 25.105 -0.867 3.707 1.00 58.31 N

ATOM 1308 C GLN A 81 30.427 1.192 1.574 1.00 43.10 C

ATOM 1309 O GLN A 81 30.390 1.526 0.406 1.00 44.40 O

ATOM 1310 N ILE A 82 30.926 1.983 2.500 1.00 42.20 N

ATOM 1312 CA ILE A 82 31.227 3.374 2.148 1.00 41.78 C

ATOM 1314 CB ILE A 82 29.952 4.210 2.093 1.00 43.88 C

ATOM 1316 CGl ILE A 82 30.226 5.693 1.936 1.00 44.99 C

ATOM 1319 CDl ILE A 82 28.980 6.417 1.322 1.00 47.81 C

ATOM 1323 CG2 ILE A 82 29.181 4.105 3.300 1.00 46.56 C

ATOM 1327 C ILE A 82 32.123 4.000 3.099 1.00 40.42 C

ATOM 1328 O ILE A 82 31.890 3.965 4.277 1.00 40.10 O

ATOM 1329 N ILE A 83 33.149 4.590 2.559 1.00 40.78 N

ATOM 1331 CA ILE A 83 33.982 5.550 3.268 1.00 41.60 C

ATOM 1333 CB ILE A 83 35.472 5.198 2.997 1.00 40.44 C

ATOM 1335 CGl ILE A 83 35.765 3.848 3.622 1.00 40.01 C

ATOM 1338 CDl ILE A 83 36.743 3.034 2.815 1.00 42.41 C

ATOM 1342 CG2 ILE A 83 36.410 6.236 3.487 1.00 38.30 C

ATOM 1346 C ILE A 83 33.669 6.893 2.695 1.00 42.50 C

ATOM 1347 O ILE A 83 33.999 7.150 1.579 1.00 43.19 O

ATOM 1348 N ARG A 84 33.018 7.761 3.415 1.00 44.85 N

ATOM 1350 CA ARG A 84 32.956 9.181 2.954 1.00 47.16 C

ATOM 1352 CB ARG A 84 31.957 9.935 3.837 1.00 48.61 C

ATOM 1355 CG ARG A 84 30.620 9.238 4.016 1.00 46.73 C

ATOM 1358 CD ARG A 84 29.729 9.845 5.062 1.00 47.11 C

ATOM 1361 NE ARG A 84 28.625 8.937 5.218 1.00 49.65 N

ATOM 1363 CZ ARG A 84 27.542 8.873 4.460 1.00 52.43 C

ATOM 1364 NHl ARG A 84 27.321 9'.737 3.523 1.00 56.44 N

ATOM 1367 NH2 ARG A 84 26.651 7.905 4.649 1.00 56.44 N

ATOM 1370 C ARG A 84 34.366 9.791 3.133 1.00 47.81 C

ATOM 1371 O ARG A 84 35.119 9.296 3.931 1.00 49.72 O

ATOM 1372 N GLY A 85 34.798 10.845 2.512 1.00 49.39 N

ATOM 1374 CA GLY A 85 36.098 11.343 3.004 1.00 49.30 C ATOM 1377 C GLY A 85 36.067 12.641 3.784 1.00 51.38 C

ATOM 1378 O GLY A 85 36.672 13.702 3.350 1.00 54.87 O

ATOM 1379 N ASN A 86 35.350 12.634 4.894 1.00 50.44 N

ATOM 1381 CA ASN A 86 35.247 13.909 5.616 1.00 53.16 C

ATOM 1383 CB ASN A 86 34.137 13.970 6.662 1.00 54.49 C

ATOM 1386 CG ASN A 86 32.855 13.473 6.133 1.00 56.57 C

ATOM 1387 ODl ASN A 86 32.589 13.516 4.880 1.00 57.07 O

ATOM 1388 ND2 ASN A 86 32.041 12.937 7.053 1.00 58.10 N

ATOM 1391 C ASN A 86 36.544 14.299 6.243 1.00 52.27 C

ATOM 1392 O ASN A 86 36.736 15.441 6.387 1.00 54.97 O

ATOM 1393 N MET A 87 37.376 13.355 6.672 1.00 49.69 N

ATOM 1395 CA MET A 87 38.812 13.569 6.874 1.00 50.28 C

ATOM 1397 CB MET A 87 39.369 13.214 8.246 1.00 50.21 C

ATOM 1400 CG MET A 87 38.562 13.459 9.436 1.00 54.83 C

ATOM 1403 SD MET A 87 39.259 14.846 10.126 1.00 63.81 S

ATOM 1404 CE MET A 87 38.913 15.937 8.831 1.00 64.30 C

ATOM 1408 C MET A 87 39.563 12.647 5..990 1.00 48.04 C

ATOM 1409 O MET A 87 39.001 11.677 5..499 1.00 46.37 O

ATOM 1410 N TYR A 88 40.857 12.939 5..889 1.00 49.45 N

ATOM 1412 CA TYR A 88 41.828 12.188 5..123 1.00 49.57 C

ATOM 1414 CB TYR A 88 42.405 13.024 3..985 1.00 50.98 C

ATOM 1417 CG TYR A 88 41.429 13.553 2, .930 1.00 53.15 C

ATOM 1418 CDl TYR A 88 41.227 14.877 2.711 1.00 57.66 C

ATOM 1420 CEl TYR A 88 40.400 15.281 1.763 1.00 56.97 C

ATOM 1422 CZ TYR A 88 39.767 14.410 0.984 1.00 52.93 C

ATOM 1423 OH TYR A 88 38.880 14.736 0.021 1.00 53.52 O

ATOM 1425 CE2 TYR A 88 39.952 13.177 1.150 1.00 52.34 C

ATOM 1427 CD2 TYR A 88 40.787 12.717 2.112 1.00 54.43 C

ATOM 1429 C TYR A 88 43.005 11.772 5.994 1.00 50.38 C

ATOM 1430 O TYR A 88 43.540 12.623 6.636 1.00 51.81 O

ATOM 1431 N TYR A 89 43.461 10.494 6.003 1.00 49.68 N

ATOM 1433 CA TYR A 89 44.851 10.226 6.458 1.00 51.12 C

ATOM 1435 CB TYR A 89 45.199 8.793 6.230 1.00 48.69 C

ATOM 1438 CG TYR A 89 46.550 8.377 6.698 1.00 49.97 C

ATOM 1439 CDl TYR A 89 46.788 8.184 7.998 1.00 52.94 C

ATOM 1441 CEl TYR A 89 48.046 7.787 8.456 1.00 54.76 C

ATOM 1443 CZ TYR A 89 49.063 7.565 7.595 1.00 53.29 C

ATOM 1444 OH TYR A 89 50.254 7.164 8.142 1.00 54.86 O

ATOM 1446 CE2 TYR A 89 48.855 7.728 6.279 1.00 52.09 C

ATOM 1448 CD2 TYR A 89 47.581 8.133 5.832 1.00 52.11 C

ATOM 1450 C TYR A 89 45.758 11.121 5.592 1.00 54.75 C

ATOM 1451 O TYR A 89 45.311 11.553 4.499 1.00 57.07 O

ATOM 1452 N GLU A 90 46.990 11.416 6.012 1.00 56.38 N

ATOM 1454 CA GLU A 90 47.978 12.129 5.116 1.00 58.43 C

ATOM 1456 CB GLU A 90 49.394 11.443 5.224 1.00 60.02 C

ATOM 1459 CG GLϋ A 90 49.655 10.346 4.183 1.00 63.93 C

ATOM 1462 CD GLU A 90 51.108 9.763 4.087 1.00 72.04 C

ATOM 1463 OEl GLU A 90 52.082 10.496 4.526 1.00 73.67 O

ATOM 1464 OE2 GLU A 90 51.246 8.551 3.534 1.00 70.25 O

ATOM 1465 C GLU A 90 47.584 12.478 3.607 1.00 56.72 C

ATOM 1466 O GLU A 90 47.069 11.643 2.909 1.00 53.74 O

ATOM 1467 N ASN A 91 47.844 13.712 3.136 1.00 59.85 N

ATOM 1469 CA ASN A 91 47.846 14.086 1.691 1.00 61.10 C

ATOM 1471 CB ASN A 91 48.956 13.309 0.852 1.00 62.38 C

ATOM 1474 CG ASN A 91 50.403 13.342 1.452 1.00 66.43 C

ATOM 1475 ODl ASN A 91 51.269 14.148 1.040 1.00 66.35 O

ATOM 1476 ND2 ASN A 91 50.692 12.379 2.344 1.00 68.77 N

ATOM 1479 C ASN A 91 46.511 13.735 1.008 1.00 57.87 C

ATOM 1480 O ASN A 91 46.489 13.144 -0.104 1.00 58.73 O

ATOM 1481 N SER A 92 45.373 13.936 1.639 1.00 54.13 N

ATOM 1483 CA SER A 92 44.142 13.510 0.901 1.00 50.01 C

ATOM 1485 CB SER A 92 43.991 14.441 -0.308 1.00 53.39 C

ATOM 1488 OG SER A 92 44.397 13.795 -1.479 1.00 55.51 O

ATOM 1490 C SER A 92 43.861 11.994 0.390 1.00 45.90 C

ATOM 1491 O SER A 92 43.244 11.776 -0.632 1.00 45.63 O

ATOM 1492 N TYR A 93 44.238 11.012 1.185 1.00 44.30 N

ATOM 1494 CA TYR A 93 43.804 9.637 0.991 1.00 42.94 C

ATOM 1496 CB TYR A 93 44.955 8.620 1.158 1.00 41.72 C ATOM 1499 CG TYR A 93 46.166 8.787 0.278 1.00 43.87 C

ATOM 1500 CDl TYR A 93 47.407 9.146 0.829 1.00 46.10 C

ATOM 1502 CEl TYR A 93 48.541 9.327 0.012 1.00 50.76 C

ATOM 1504 CZ TYR A 93 48.439 9.139 -1.371 1.00 48.97 C

ATOM 1505 OH TYR A 93 49.527 9.284 -2.159 1.00 51.85 O

ATOM 1507 CE2 TYR A 93 47.228 8.775 -1.937 1.00 47.04 C

ATOM 1509 CD2 TYR A 93 46.087 8.588 -1.104 1.00 44.48 C

ATOM 1511 C TYR A 93 42.754 9.357 2.068 1.00 42.52 C

ATOM 1512 O TYR A 93 43.009 9.539 3.289 1.00 42.34 O

ATOM 1513 N ALA A 94 41.585 8.947 1.581 1.00 42.12 N

ATOM 1515 CA ALA A 94 40.467 8.458 .386 1.00 41.29 C

ATOM 1517 CB ALA A 94 39.124 8.712 .688 1.00 41.93 C

ATOM 1521 C ALA A 94 40.538 7.046 .741 1.00 36.58 C

ATOM 1522 O ALA A 94 39.832 6.652 .648 1.00 38.88 O

ATOM 1523 N LEU A 95 41.322 6.287 .976 1.00 37.35 N

ATOM 1525 CA LEU A 95 41.677 4.889 .345 1.00 36.53 C

ATOM 1527 CB LEU A 95 40.838 .878 .575 1.00 35.59 C

ATOM 1530 CG LED A 95 41.249 .405 .730 1.00 38.72 C

ATOM 1532 CDl LEU A 95 40.952 .856 .092 1.00 38.41 C

ATOM 1536 CD2 LEU A 95 40.553 .538 0.725 1.00 40.76 C

ATOM 1540 C LEU A 95 43.155 .620 097 1.00 36.96 C

ATOM 1541 O LEU A 95 43.702 .902 040 1.00 36.85 O

ATOM 1542 N ALA A 96 43.811 .030 064 1.00 36.75 N

ATOM 1544 CA ALA A 96 45.256 .954 964 1.00 39.78 C

ATOM 1546 CB ALA A 96 45.925 5.164 605 1.00 41.49 C

ATOM 1550 C ALA A 96 45.666 2.689 629 1.00 40.17 C

ATOM 1551 O ALA A 96 45.306 2.465 4.723 1.00 39.98 O

ATOM 1552 N VAL A 97 46.352 1.827 ,908 1.00 41.75 N

ATOM 1554 CA VAL A 97 46.585 0.484 .341 1.00 42.09 C

ATOM 1556 CB VAL A 97 45.788 ^■0.476 .463 1.00 41.49 C

ATOM 1558 CGl VAL A 97 46.026 -1 918 .852 1.00 42.14 C

ATOM 1562 CG2 VAL A 97 44.323 ■0.177 2.615 1.00 41.22 C

ATOM 1566 C VAL A 97 48.086 0.352 3.161 1.00 44.34 C

ATOM 1567 O VAL A 97 48.554 0.134 2.051 1.00 45.40 O

ATOM 1568 N LEU A 98 48.818 0.528 4.272 1.00 45.17 N

ATOM 1570 CA LEU A 98 50.276 0.703 4.325 1.00 46.32 C

ATOM 1572 CB LEU A 98 50.596 2.056 4.941 1.00 47.45 C

ATOM 1575 CG LEU A 98 49.900 3.267 4.427 1.00 46.46 C

ATOM 1577 CDl LEU A 98 50.711 4.432 4.845 1.00 49.07 C

ATOM 1581 CD2 LEU A 98 49.904 3.181 2.962 1.00 49.37 C

ATOM 1585 C LEU A 98 51.052 •0.301 5.190 1.00 46.58 C

ATOM 1586 O LEU A 98 50.744 ^■0.562 6.346 1.00 44.34 O

ATOM 1587 N SER A 99 52.121 ^■0.774 4.585 1.00 48.54 N

ATOM 1589 CA SER A 99 53.196 ^■1.505 5.215 1.00 51.61 C

ATOM 1591 CB SER A 99 54.303 0.529 5.593 1.00 54.70 C

ATOM 1594 OG SER A 99 53.951 0.131 6.737 1.00 56.30 O

ATOM 1596 C SER A 99 52.781 ^■2.478 6.314 1.00 50.51 C

ATOM 1597 O SER A 99 53.385 ^■2.555 7.367 1.00 51.44 O

ATOM 1598 N ASN A 100 51.810 •3.301 5.909 1.00 48.91 N

ATOM 1600 CA ASN A 100 51.163 4.336 6.673 1.00 48.16 C

ATOM 1602 CB ASN A 100 49.731 596 6.150 1.00 45.34 C

ATOM 1605 CG ASN A 100 48.753 488 6.537 1.00 43.98 C

ATOM 1606 ODl ASN A 100 48.493 220 7.752 1.00 44.49 O

ATOM 1607 ND2 ASN A 100 48.219 820 5.529 1.00 40.05 N

ATOM 1610 C ASN A 100 51.948 611 6.590 1.00 50.03 C

ATOM 1611 O ASN A 100 51.466 6.581 6.059 1.00 49.67 O

ATOM 1612 N TYR A 101 53.167 5.561 7.095 1.00 52.63 N

ATOM 1614 CA TYR A 101 54.057 6.682 7.206 1.00 55.81 C

ATOM 1616 CB TYR A 101 54.935 6.876 5.957 1.00 57.44 C

ATOM 1619 CG TYR A 101 55.910 5.739 5.711 1.00 61.09 C

ATOM 1620 CDl TYR A 101 57.282 -5 915 5.822 1.00 65.26 C

ATOM 1622 CEl TYR A 101 58.178 ■4.835 5.598 1.00 67.71 C

ATOM 1624 CZ TYR A 101 57.689 ^•3.571 5.279 1.00 66.52 C

ATOM 1625 OH TYR A 101 58.504 -2 489 5.080 1.00 66.74 O

ATOM 1627 CE2 TYR A 101 56.339 3.370 5.169 1.00 63.37 C

ATOM 1629 CD2 TYR A 101 55.450 4.453 5.380 1.00 61.79 C

ATOM 1631 C TYR A 101 54.922 6.375 8.399 1.00 59.02 C

ATOM 1632 O TYR A 101 54.849 5.281 8.984 1.00 59.11 O ATOM 1633 N ASP A 102 55.740 -7.351 8.775 1.00 62.99 N

ATOM 1635 CA ASP A 102 56.695 -7. 200 9.858 1.00 66.01 C

ATOM 1637 CB ASP A 102 56.193 -7.849 11.169 1.00 66.35 C

ATOM 1640 CG ASP A 102 56.362 -9.374 11.239 1.00 70.03 C

ATOM 1641 ODl ASP A 102 56.452 -10.092 10.212 1.00 73.62 O

ATOM 1642 OD2 ASP A 102 56.400 -9.961 12.340 1.00 72.18 O

ATOM 1643 C ASP A 102 58.069 -7.681 9.459 1.00 69.88 C

ATOM 1644 O ASP A 102 58.284 -8.255 8.390 1.00 69.60 O

ATOM 1645 N ALA A 103 59.005 -7.382 10.340 1.00 73.77 N

ATOM 1647 CA ALA A 103 60.390 -7.786 10.188 1.00 78.79 C

ATOM 1649 CB ALA A 103 61.234 -7.388 11.471 1.00 82.44 C

ATOM 1653 C ALA A 103 60.469 -9.265 9.936 1.00 80.28 C

ATOM 1654 O ALA A 103 61.349 -9.677 9.202 1.00 83.58 O

ATOM 1655 N ASN A 104 59.535 -10.036 10.519 1.00 78.84 N

ATOM 1657 CA ASN A 104 59.562 -11.517 10.518 1.00 81.30 C

ATOM 1659 CB ASN A 104 58.700 -12.058 11.667 1.00 80.83 C

ATOM 1662 CG ASN A 104 59.503 -12.368 12.896 1.00 85.11 C

ATOM 1663 ODl ASN A 104 60.124 -13.432 12.973 1.00 88.51 O

ATOM 1664 ND2 ASN A 104 59.490 -11.439 13.881 1.00 83.35 N

ATOM 1667 C ASN A 104 59.156 -12.295 9.262 1.00 80.02 C

ATOM 1668 O ASN A 104 59.059 -13.525 9.360 1.00 81.89 O

ATOM 1669 N ALA A 105 58.967 -11.613 8.120 1.00 77.36 N

ATOM 1671 CA ALA A 105 58.482 -12.224 6.874 1.00 76.38 C

ATOM 1673 CB ALA A 105 59.452 -13.356 6.374 1.00 80.34 C

ATOM 1677 C ALA A 105 57.000 -12.731 6.961 1.00 73.17 C

ATOM 1678 O ALA A 105 56.718 -13.889 6.700 1.00 73.97 O

ATOM 1679 N THR A 106 56.081 -11.824 7.298 1.00 69.66 N

ATOM 1681 CA THR A 106 54.660 -12.097 7.532 1.00 66.80 C

ATOM 1683 CB THR A 106 54.420 -12.371 9.047 1.00 68.37 C

ATOM 1685 OGl THR A 106 55.307 -13.390 9.523 1.00 72.58 O

ATOM 1687 CG2 THR A 106 52.978 -12.913 9.329 1.00 67.58 C

ATOM 1691 C THR A 106 53.902 -10.812 7.270 1.00 62.45 C

ATOM 1692 O THR A 106 54.416 -9.762 7.574 1.00 62.25 O

ATOM 1693 N GLY A 107 52.673 -10.886 6.782 1.00 58.72 N

ATOM 1695 CA GLY A 107 51.864 -9.712 6.675 1.00 55.00 C

ATOM 1698 C GLY A 107 50.400 -9.905 6.384 1.00 53.15 C

ATOM 1699 O GLY A 107 49.843 -10.953 6.433 1.00 53.80 O

ATOM 1700 N LEU A 108 49.751 -8.814 6.049 1.00 52.41 N

ATOM 1702 CA LEU A 108 48.340 -8.814 5.782 1.00 50.68 C

ATOM 1704 CB LEU A 108 47.813 -7.395 5.753 1.00 47.39 C

ATOM 1707 CG LEU A 108 46.336 -7.409 5.418 1.00 45.14 C

ATOM 1709 CDl LEU A 108 45.449 -8.110 6.475 1.00 45.32 C

ATOM 1713 CD2 LEU A 108 45.931 -5.996 5.325 1.00 43.71 C

ATOM 1717 C LEU A 108 48.153 -9.472 4.422 1.00 52.50 C

ATOM 1718 O LEU A 108 48.849 -9.151 3.447 1.00 55.00 O

ATOM 1719 N LYS A 109 47.179 -10.355 4.355 1.00 52.74 N

ATOM 1721 CA LYS A 109 46.955 -11.238 3.229 1.00 53.15 C

ATOM 1723 CB LYS A 109 47.638 -12.559 3.644 1.00 55.47 C

ATOM 1726 CG LYS A 109 47.261 -13.758 2.850 1.00 58.35 C

ATOM 1729 CD LYS A 109 47.898 -15.038 3.348 1.00 64.60 C

ATOM 1732 CE LYS A 109 47.531 -16.247 2.-344 1.00 68.67 C

ATOM 1735 NZ LYS A 109 48.322 -17.517 2.627 1.00 71.64 N

ATOM 1739 C LYS A 109 45.472 -11.376 3.326 1.00 51.57 C

ATOM 1740 O LYS A 109 45.043 -11.938 4.301 1.00 55.49 O

ATOM 1741 N GLU A 110 44.629 -10.868 .482 1.00 48.33 N

ATOM 1743 CA GLU A 110 43.162 -10.946 .841 1.00 47.27 C

ATOM 1745 CB GLU A 110 42.668 -12.235 .564 1.00 48.52 C

ATOM 1748 CG GLU A 110 42.930 -13.571 .828 1.00 52.86 C

ATOM 1751 CD GLU A 110 42.513 -14.864 .570 1.00 55.78 C

ATOM 1752 OEl GLU A 110 41.488 -14.854 .321 1.00 53.35 O

ATOM 1753 OE2 GLU A 110 43.190 -15.927 3.337 1.00 63.72 O

ATOM 1754 C GLU A 110 42.519 -9.791 3.590 1.00 44.72 C

ATOM 1755 O GLU A 110 42.327 -9.843 4.769 1.00 44.16 O

ATOM 1756 N LEU A 111 42.058 -8.851 2.780 1.00 42.81 N

ATOM 1758 CA LEU A 111 41.322 -7.684 3.153 1.00 41.48 C

ATOM 1760 CB LEU A 111 42.164 -6.445 2.787 1.00 40.76 C

ATOM 1763 CG LEU A 111 41.578 -5.068 2.935 1.00 39.62 C

ATOM 1765 CDl LEU A 111 41.011 -4.863 4.331 1.00 41.72 C ATOM 1769 CD2 LEU A 111 42.691 -4.060 2.710 1.00 39.92 C

ATOM 1773 C LEU A 111 40.103 -7.645 2.272 1.00 41.38 C

ATOM 1774 O LEU A 111 40.014 -6.823 1.395 1.00 42.26 O

ATOM 1775 N PRO A 112 39.179 -8.521 2.525 1.00 41.64 N

ATOM 1776 CA PRO A 112 38.060 -8.786 1.640 1.00 42.53 C

ATOM 1778 CB PRO A 112 37.638 -10.175 2.115 1.00 44.60 C

ATOM 1781 CG PRO A 112 37.805 -10.066 3.588 1.00 43.64 C

ATOM 1784 CD PRO A 112 39.114 -9.318 3.760 1.00 43.26 C

ATOM 1787 C PRO A 112 36.845 -7.849 1.760 1.00 42.22 C

ATOM 1788 O PRO A 112 35.765 -8.273 2.247 1.00 43.92 O

ATOM 1789 N MET A 113 36.976 -6.650 1.225 1.00 41.57 N

ATOM 1791 CA MET A 113 35.973 -5.586 1.353 1.00 41.49 C

ATOM 1793 CB MET A 113 36.676 -4.230 1.468 1.00 40.58 C

ATOM 1796 CG MET A 113 37.824 -4, 291 2.459 1.00 41.70 C

ATOM 1799 SD MET A 113 38.645 -2, 730 2.961 1.00 44.40 S

ATOM 1800 CE MET A 113 38.085 -1.709 1.780 1.00 48.11 C

ATOM 1804 C MET A 113 35.088 -5.639 0.146 1.00 42.26 C

ATOM 1805 O MET A 113 35.080 -4.740 -0.708 1.00 42.73 O

ATOM 1806 N ARG A 114 34.344 -6.726 0.053 1.00 42.70 N

ATOM 1808 CA ARG A 114 33.513 -6.960 -1.108 1.00 43.40 C

ATOM 1810 CB ARG A 114 33.165 -8.423 -1.136 1.00 45.30 C

ATOM 1813 CG ARG A 114 32.163 -8.694 -0.123 1.00 48.87 C

ATOM 1816 CD ARG A 114 32.431 -9.967 0.498 1.00 54.37 C

ATOM 1819 NE ARG A 114 31.551 -10.186 1.603 1.00 56.34 N

ATOM 1821 CZ ARG A 114 31.514 -11.297 2.263 1.00 55.48 C

ATOM 1822 NHl ARG A 114 32.344 -12.304 1.982 1.00 51.37 N

ATOM 1825 NH2 ARG A 114 30.674 -11.331 3.277 1.00 60.58 N

ATOM 1828 C ARG A 114 32.209 -6.193 -1.176 1.00 42.43 C

ATOM 1829 O ARG A 114 31.422 -6.405 -2.096 1.00 43.72 O

ATOM 1830 N ASN A 115 31.936 -5.385 -0.165 1.00 41.74 N

ATOM 1832 CA ASN A 115 30.800 -4.474 -0.183 1.00 42.25 C

ATOM 1834 CB ASN A 115 29.944 -4.676 1.039 1.00 43.29 C

ATOM 1837 CG ASN A 115 29.106 -5.845 0.914 1.00 44.56 C

ATOM 1838 ODl ASN A 115 28.419 -6.041 -0.040 1.00 47.36 O

ATOM 1839 ND2 ASN A 115 29.181 -6.668 1.865 1.00 52.65 N

ATOM 1842 C ASN A 115 31.177 -3.013 -0.329 1.00 40.39 C

ATOM 1843 O ASN A 115 30.332 -2.226 -0.638 1.00 41.23 O

ATOM 1844 N LEU A 116 32.440 -2.683 -0.159 1.00 38.95 N

ATOM 1846 CA LEU A 116 32.917 -1.357 -0.384 1.00 39.18 C

ATOM 1848 CB LEU A 116 34.415 -1.245 -0.029 1.00 37.99 C

ATOM 1851 CG LEU A 116 34.961 0.166 -0.304 1.00 38.33 C

ATOM 1853 CDl LEU A 116 34.239 1.149 0.563 1.00 39.42 C

ATOM 1857 CD2 LEU A 116 36.421 0.263 -0.035 1.00 38.20 C

ATOM 1861 C LEU A 116 32.611 -0.853 -1.839 1.00 40.77 C

ATOM 1862 O LEU A 116 33.220 -1.240 -2.811 1.00 41.13 O

ATOM 1863 N GLN A 117 31.641 0.020 -1.950 1.00 41.94 N

ATOM 1865 CA GLN A 117 31.185 0.433 -3.228 1.00 44.45 C

ATOM 1867 CB GLN A 117 29.790 -0.099 -3.459 1.00 46.41 C

ATOM 1870 CG GLN A 117 29.915 -1.437 -4.132 1.00 50.06 C

ATOM 1873 CD GLN A 117 28.659 -2.188 -4.162 1.00 54.73 C

ATOM 1874 OEl GLN A 117 27.898 -2.178 -3.185 1.00 56.09 O

ATOM 1875 NE2 GLN A 117 28.436 -2.883 -5.252 1.00 56.36 N

ATOM 1878 C GLN A 117 31.319 1.908 -3.539 1.00 44.91 C

ATOM 1879 O GLN A 117 31.561 2.178 -4.686 1.00 47.48 O

ATOM 1880 N GLU A 118 31.246 2.824 -2.567 1.00 43.90 N

ATOM 1882 CA GLU A 118 31.630 4.203 -2.827 1.00 44.87 C

ATOM 1884 CB GLU A 118 30.338 5.058 -3.007 1.00 48.13 C

ATOM 1887 CG GLU A 118 30.326 6.583 -3.040 1.00 50.77 C

ATOM 1890 CD GLU A 118 30.632 7.244 -4.365 1.00 56.86 C

ATOM 1891 OEl GLU A 118 31.202 6.589 -5.234 1.00 65.98 O

ATOM 1892 OE2 GLU A 118 30.462 8.468 -4.540 1.00 58.62 O

ATOM 1893 C GLU A 118 32.606 4.742 -1.785 1.00 42.40 C

ATOM 1894 O GLU A 118 32.534 4.414 -0.641 1.00 40.40 O

ATOM 1895 N ILE A 119 33.550 5.555 -2.272 1.00 42.58 N

ATOM 1897 CA ILE A 119 34.382 6.462 -1.481 1.00 41.49 C

ATOM 1899 CB ILE A 119 35.884 6.155 -1.688 1.00 40.87 C

ATOM 1901 CGl ILE A 119 36.283 4.839 -1.043 1.00 40.15 C

ATOM 1904 CDl ILE A 119 37.837 4.504 -1.293 1.00 40.31 C ATOM 1908 CG2 ILE A 119 36.808 7.251 1.096 1.00 40.44 C

ATOM 1912 C ILE A 119 34.012 7.873 1.961 1.00 41.94 C

ATOM 1913 O ILE A 119 34.441 8.325 3.039 1.00 44.53 O

ATOM 1914 N LEU A 120 33.182 8.572 1.200 1.00 42.54 N

ATOM 1916 CA LEU A 120 32.619 9.831 1.705 1.00 46.08 C

ATOM 1918 CB LEU A 120 31.798 10.529 0.657 1.00 47.62 C

ATOM 1921 CG LEU A 120 30.428 10.004 0.329 1.00 50.88 C

ATOM 1923 CDl LEU A 120 29.763 11.116 0.529 1.00 54.37 C

ATOM 1927 CD2 LEU A 120 29.652 9.701 1.610 1.00 50.49 C

ATOM 1931 C LEU A 120 33.658 10.830 2.141 1.00 46.27 C

ATOM 1932 O LEU A 120 33.462 11.522 3.112 1.00 48.50 O

ATOM 1933 N HIS A 121 34.737 10.906 1.361 1.00 45.34 N

ATOM 1935 CA HIS A 121 35.891 11.734 1.632 1.00 45.38 C

ATOM 1937 CB HIS A 121 35.889 12.961 0.796 1.00 47.60 C

ATOM 1940 CG HIS A 121 34.582 13.616 0.646 1.00 47.72 C

ATOM 1941 NDl HIS A 121 34.347 14.891 1.097 1.00 49.72 N

ATOM 1943 CEl HIS A 121 33.129 15.251 0.758 1.00 50.90 C

ATOM 1945 NE2 HIS A 121 32.577 14.277 0.081 1.00 49.78 N

ATOM 1947 CD2 HIS A 121 33.480 13.248 0.038 1.00 47.09 C

ATOM 1949 C HIS A 121 37.208 11.131 1.263 1.00 44.24 C

ATOM 1950 O HIS A 121 37.331 10.470 0.247 1.00 43.40 O

ATOM 1951 N GLY A 122 38.215 11.496 2.036 1.00 46.45 N

ATOM 1953 CA GLY A 122 39.568 11.184 1.687 1.00 46.38 C

ATOM 1956 C GLY A 122 40.066 10.056 2.530 1.00 46.66 C

ATOM 1957 O GLY A 122 39.309 9.308 3.132 1.00 44.50 O

ATOM 1958 N ALA A 123 41.369 9.924 2.491 1.00 47.30 N

ATOM 1960 CA ALA A 123 42.029 8.889 3.172 1.00 47.38 C

ATOM 1962 CB ALA A 123 43.273 9.481 3.863 1.00 49.98 C

ATOM 1966 C ALA A 123 42.350 7.675 2.244 1.00 44.62 C

ATOM 1967 O ALA A 123 41.818 7.512 1.158 1.00 43.85 O

ATOM 1968 N VAL A 124 43.114 6.733 2.791 1.00 45.41 N

ATOM 1970 CA VAL A 124 43.423 5.507 2.138 1.00 43.66 C

ATOM 1972 CB VAL A 124 42.721 4.412 2.827 1.00 42.78 C

ATOM 1974 CGl VAL A 124 43.053 3.093 2.159 1.00 44.72 C

ATOM 1978 CG2 VAL A 124 41.231 4.593 2.655 1.00 42.04 C

ATOM 1982 C VAL A 124 44.902 5.256 2.142 1.00 44.48 C

ATOM 1983 O VAL A 124 45.611 5.612 3.083 1.00 46.68 O

ATOM 1984 N ARG A 125 45.391 4.622 1.099 1.00 43.14 N

ATOM 1986 CA ARG A 125 46.761 4.216 1.137 1.00 44.94 C

ATOM 1988 CB ARG A 125 47.589 5.115 0.277 1.00 47.27 C

ATOM 1991 CG ARG A 125 49.029 4.742 0.264 1.00 51.74 C

ATOM 1994 CD ARG A 125 49.897 5.906 0.139 1.00 57.79 C

ATOM 1997 NE ARG A 125 51.268 5.694 0.336 1.00 64.37 N

ATOM 1999 CZ ARG A 125 52.378 5.749 0.419 1.00 67.82 C

ATOM 2000 NHl ARG A 125 52.312 6.066 1.746 1.00 67.17 N

ATOM 2003 NH2 ARG A 125 53.565 5.492 0.178 1.00 68.87 N

ATOM 2006 C ARG A 125 46.936 2.808 0.655 1.00 43.08 C

ATOM 2007 O ARG A 125 46.596 2.460 0.469 1.00 39.00 O

ATOM 2008 N PHE A 126 47.508 2.011 1.552 1.00 44.38 N

ATOM 2010 CA PHE A 126 48.137 0.783 1.167 1.00 44.03 C

ATOM 2012 CB PHE A 126 47.510 -0.344 1.926 1.00 43.71 C

ATOM 2015 CG PHE A 126 46.218 -0.807 1.391 1.00 40.01 C

ATOM 2016 CDl PHE A 126 45.108 -0.080 1.549 1.00 40.92 C

ATOM 2018 CEl PHE A 126 43.887 -0.550 1.063 1.00 39.27 C

ATOM 2020 CZ PHE A 126 43.775 -1.763 0.456 1.00 38.94 C

ATOM 2022 CE2 PHE A 126 44.833 -2.509 0.371 1.00 42.57 C

ATOM 2024 CD2 PHE A 126 46.088 -2.034 0.854 1.00 42.75 C

ATOM 2026 C PHE A 126 49.648 0.852 1.465 1.00 46.82 C

ATOM 2027 O PHE A 126 50.036 1.090 2.614 1.00 47.64 O

ATOM 2028 N SER A 127 50.476 0.631 0.423 1.00 47.70 N

ATOM 2030 CA SER A 127 51.910 0.385 0.566 1.00 51.19 C

ATOM 2032 CB SER A 127 52.649 1.696 0.466 1.00 54.02 C

ATOM 2035 OG SER A 127 53.034 1.883 0.885 1.00 57.27 O

ATOM 2037 C SER A 127 52.481 -0.594 0.485 1.00 51.56 C

ATOM 2038 O SER A 127 52.047 -0.628 1.604 1.00 49.36 O

ATOM 2039 N ASN A 128 53.468 -1.391 0.078 1.00 54.77 N

ATOM 2041 CA ASN A 128 54.264 -2.229 0.968 1.00 56.21 C

ATOM 2043 CB ASN A 128 55.137 -1.373 1.877 1.00 58.23 C ATOM 2046 CG ASN A 128 56.046 -0.407 1.097 1..00 62.17 C

ATOM 2047 ODl ASN A 128 57.182 -0.758 0.790 1..00 66.14 O

ATOM 2048 ND2 ASN A 128 55.556 0.817 0.799 1..00 58.01 N

ATOM 2051 C ASN A 128 53.402 -3.228 1.755 1..00 54.35 C

ATOM 2052 O ASN A 128 53.461 -3.340 2.990 1..00 53.42 O

ATOM 2053 N ASN A 129 52.624 -3.990 0.999 1..00 53.03 N

ATOM 2055 CA ASN A 129 51.809 -5.034 1.562 1..00 51.72 C

ATOM 2057 CB ASN A 129 50.355 -4.712 1.281 1..00 48.91 C

ATOM 2060 CG ASN A 129 49.950 -3.386 1.877 1..00 48.71 C

ATOM 2061 ODl ASN A 129 49.956 -3.219 3.097 1..00 46.84 O

ATOM 2062 ND2 ASN A 129 49.620 -2.425 1.021 1..00 49.70 N

ATOM 2065 C ASN A 129 52.142 -6.394 0.988 1..00 53.27 C

ATOM 2066 O ASN A 129 51.301 -6.990 0.376 1..00 52.88 O

ATOM 2067 N PRO A 130 53.322 -6.931 1.248 1.00 55.86 N

ATOM 2068 CA PRO A 130 53.849 -8.030 0.441 1.00 58.30 C

ATOM 2070 CB PRO A 130 55.334 -8.067 0.806 .00 61.57 C

ATOM 2073 CG PRO A 130 55.422 -7.439 2.170 .00 61.58 C

ATOM 2076 CD PRO A 130 54.194 -6.614 2.386 00 57.72 C

ATOM 2079 C PRO A 130 53.194 -9.378 0.718 00 58.29 C

ATOM 2080 O PRO A 130 53.617 -10.382 0.197 00 60.97 O

ATOM 2081 N ALA A 131 52.151 -9.438 1.513 00 55.73 N

ATOM 2083 CA ALA A 131 51.452 -10.692 1..621 00 54.80 C

ATOM 2085 CB ALA A 131 51.407 -11.073 3..006 00 54.50 C

ATOM 2089 C ALA A 131 50.056 -10.559 1..046 00 52.04 C

ATOM 2090 O ALA A 131 49.305 -11.499 1..010 1.00 52.22 O

ATOM 2091 N LEO A 132 49.731 -9.399 0.527 1.00 50.22 N

ATOM 2093 CA LEO A 132 48.347 -9.100 0.235 1.00 48.25 C

ATOM 2095 CB LEO A 132 48.111 -7.577 0.094 1.00 46.58 C

ATOM 2098 CG LEO A 132 46.693 -7.049 -0.140 1.00 42.72 C

ATOM 2100 CDl LEO A 132 45.792 -7.428 0.981 1.00 41.93 C

ATOM 2104 CD2 LEO A 132 46.701 -5.522 -0.330 1.00 41.41 C

ATOM 2108 C LEO A 132 47.923 -9.826 .003 00 49.53 C

ATOM 2109 O LEO A 132 48.735 -10.093 .883 00 51.28 O

ATOM 2110 N CYS A 133 46.636 -10.148 .031 1.00 49.32 N

ATOM 2112 CA CYS A 133 46.017 -10.944 .085 1.00 51.07 C

ATOM 2114 CB CYS A 133 45.605 -12.286 -1.533 1.00 51.93 C

ATOM 2117 SG CYS A 133 47.113 -13.311 -1.525 00 58.93 S

ATOM 2118 C CYS A 133 44.814 -10.287 -2.732 00 49.03 C

ATOM 2119 O CYS A 133 44.089 -9.538 -2.070 00 47.78 O

ATOM 2120 N ASN A 134 44.660 -10.569 -4.026 00 48.89 N

ATOM 2122 CA ASN A 134 43.496 -10.312 -4.800 00 47.55 C

ATOM 2124 CB ASN A 134 42.304 -11.082 -4.237 00 46.96 C

ATOM 2127 CG ASN A 134 42.563 -12.593 4.084 00 49.52 C

ATOM 2128 ODl ASN A 134 42.816 -13.265 5.038 00 51.07 O

ATOM 2129 ND2 ASN A 134 42.457 -13.112 2.870 00 48.52 N

ATOM 2132 C ASN A 134 43.169 -8.832 5.039 00 45.92 C

ATOM 2133 O ASN A 134 42.597 -8.494 ^■6.061 00 45.65 O

ATOM 2134 N VAL A 135 43.530 -7.933 ^■4.135 00 45.56 N

ATOM 2136 CA VAL A 135 42.985 -6.552 ^■4.156 00 43.82 C

ATOM 2138 CB VAL A 135 43.400 -5.780 2.932 00 42.47 C

ATOM 2140 CGl VAL A 135 43.037 -4.266 3.017 00 41.77 C

ATOM 2144 CG2 VAL A 135 42.786 -6.384 ^■1.737 00 41.35 C

ATOM 2148 C VAL A 135 43.493 -5.880 ^■5.431 00 45.40 C

ATOM 2149 O VAL A 135 42.723 -5.205 ^■6.070 00 45.40 O

ATOM 2150 N GLO A 136 44.755 -6.158 5.796 00 46.87 N

ATOM 2152 CA GLO A 136 45.404 -5.750 -7 035 00 49.44 C

ATOM 2154 CB GLO A 136 46.677 -6.586 7.316 00 52.90 C

ATOM 2157 CG GLU A 136 47.654 -6.085 8.413 00 57.64 C

ATOM 2160 CD GLU A 136 48.784 -7.097 8.714 00 66.03 C

ATOM 2161 OEl GLO A 136 49.015 -7.981 -7 798 00 68.30 O

ATOM 2162 OE2 GLO A 136 49.415 -7.041 9.837 00 70.61 O

ATOM 2163 C GLO A 136 44.526 -5.895 8.238 00 50.26 C

ATOM 2164 O GLO A 136 44.781 -5.226 ■9.234 00 52.27 O

ATOM 2165 N SER A 137 43.516 -6.745 ■8.189 00 49.34 N

ATOM 2167 CA SER A 137 42.673 -6.934 9.365 00 51.02 C

ATOM 2169 CB SER A 137 42.120 -8.342 9.390 00 51.77 C

ATOM 2172 OG SER A 137 41.372 -8.537 8.213 00 49.79 O

ATOM 2174 C SER A 137 41.521 -5.953 ^■9.408 1.00 49.35 C ATOM 2175 O SER A 137 40.737 5.909 -10.335 1.00 50.09 O

ATOM 2176 N ILE A 138 41.427 5.128 - -88..442200 1.00 47.68 N

ATOM 2178 CA ILE A 138 40.207 4.429 - -88..227722 1.00 47.46 C

ATOM 2180 CB ILE A 138 39.947 4.236 - -66..883300 1.00 45.92 C

ATOM 2182 CGl ILE A 138 39.161 5.479 - -66..440022 1.00 50.04 C

ATOM 2185 CDl ILE A 138 38.907 5.482 - -44..997799 1.00 52.31 C

ATOM 2189 CG2 ILE A 138 39.130 3.036 - -66..553355 1.00 44.29 C

ATOM 2193 C ILE A 138 40.270 3.168 - -99..001144 1 .00 48.13 C

ATOM 2194 O ILE A 138 41.305 2.535 - -99..006600 1.00 49.23 O

ATOM 2195 N GLN A 139 39.110 2.834 - -99..556677 1.00 48.49 N

ATOM 2197 CA GLN A 139 38.826 1.708 -10.439 1.00 48.81 C

ATOM 2199 CB GLN A 139 37.724 2.104 -11.446 1.00 50.08 C

ATOM 2202 CG GLN A 139 38.234 3.051 -12.588 1.00 52.30 C

ATOM 2205 CD GLN A 139 37.175 3.535 -13.588 1.00 54.29 C

ATOM 2206 OEl GLN A 139 36.906 2.864 -14.560 1.00 59.63 O

ATOM 2207 NE2 GLN A 139 36.617 4.708 -13.361 1.00 52.60 N

ATOM 2210 C GLN A 139 38.326 - 00..555533 -9.603 1.00 48.02 C

ATOM 2211 O GLN A 139 37.130 - 00..440099 -9.361 1.00 48.86 O

ATOM 2212 N TRP A 140 39.238 0 0..227799 -9.138 00 47.32 N

ATOM 2214 CA TRP A 140 38.876 1 1..441166 -8.309 1.00 45.95 C

ATOM 2216 CB TRP A 140 40.180 2.000 -7.785 1.00 46.14 C

ATOM 2219 CG TRP A 140 40.885 0.963 -6.994 1.00 46.00 C

ATOM 2220 CDl TRP A 140 41.802 0.118 -7.451 1.00 49.63 C

ATOM 2222 NEl TRP A 140 42.183 -0.754 -6.450 1.00 52.-24 N

ATOM 2224 CE2 TRP A 140 41.481 -0.469 -5.318 1.00 45.13 C

ATOM 2225 CD2 TRP A 140 40.644 0.601 -5.619 1.00 46.06 C

ATOM 2226 CE3 TRP A 140 39.843 1.122 -4.603 1. 0000 47.07 C

ATOM 2228 CZ3 TRP A 140 39.902 0.531 -3.331 1.0000 46.32 C

ATOM 2230 CH2 TRP A 140 40.751 -0.540 -3.099 1.00 44.90 C

ATOM 2232 CZ2 TRP A 140 41.559 -1.032 -4..085 1.00 44.06 C

ATOM 2234 C TRP A 140 37.958 2.468 .988 1.00 46.64 C

ATOM 2235 O TRP A 140 37.156 3.152 .417 1.00 47.16 O

ATOM 2236 N ARG A 141 38.039 2.549 -10.251 1.00 49.56 N

ATOM 2238 CA ARG A 141 37.281 3.487 -11.006 1.00 51.70 C

ATOM 2240 CB ARG A 141 37.690 3.287 -12.479 1.00 54.96 C

ATOM 2243 CG ARG A 141 37.314 4.259 -13.453 1.00 59.89 C

ATOM 2246 CD ARG A 141 37.332 3.683 -14.883 1.00 68.80 C

ATOM 2249 NE ARG A 141 36.925 4.702 -15.900 1.00 76.88 N

ATOM 2251 CZ ARG A 141 36.168 .420 -16.981 1.00 79.58 C

ATOM 2252 NHl ARG A 141 35.680 .165 -17.156 1.00 77.54 N

ATOM 2255 NH2 ARG A 141 35.910 .388 -17.889 1.00 83.87 N

ATOM 2258 C ARG A 141 35.805 3.315 -10.714 1.00 51.04 C

ATOM 2259 O ARG A 141 35.077 4.284 -10.763 1.00 52.62 O

ATOM 2260 N ASP A 142 35.337 2.129 -10.354 1.00 50.38 N

ATOM 2262 CA ASP A 142 33.936 2.014 -9.928 1.00 50.96 C

ATOM 2264 CB ASP A 142 33.502 0.590 -9.927 1.00 51.24 C

ATOM 2267 CG ASP A 142 32.027 0.437 -9.613 1.00 56.27 C

ATOM 2268 ODl ASP A 142 31.590 0.872 -8.537 1.00 64.27 O

ATOM 2269 OD2 ASP A 142 31.195 -0.113 -10.333 1.00 62.04 O

ATOM 2270 C ASP A 142 33.730 2.575 -E .491 1.00 48.89 C

ATOM 2271 O ASP A 142 32.639 3.015 .113 1.00 47.96 O

ATOM 2272 N ILE A 143 34.781 2.510 -7.685 1.00 47.20 N

ATOM 2274 CA ILE A 143 34.745 2.956 -6.294 1.00 44.55 C

ATOM 2276 CB ILE A 143 35.712 2.142 -5.533 1.00 42.17 C

ATOM 2278 CGl ILE A 143 35.086 0.768 -5.327 1.00 40.78 C

ATOM 2281 CDl ILE A 143 36.133 -0.301 -5.046 1.00 40.44 C

ATOM 2285 CG2 ILE A 143 36.018 2.787 -4.247 1.00 41.34 C

ATOM 2289 C ILE A 143 35.044 4.401 -6.069 1.00 44.56 C

ATOM 2290 O ILE A 143 34.327 5.095 -5.380 1.00 44.62 O

ATOM 2291 N VAL A 144 36.124 4.863 -6.630 1.00 45.00 N

ATOM 2293 CA VAL A 144 3,6.509 6.218 -6.403 1.00 45.50 C

ATOM 2295 CB VAL A 144 38.028 6.287 -6.507 1.00 45.97 C

ATOM 2297 CGl VAL A 144 38.574 .708 -6.491 1.00 48.38 C

ATOM 2301 CG2 VAL A 144 38.596 .619 -5.328 1.00 43.75 C

ATOM 2305 C VAL A 144 35.797 .249 -7.293 1.00 48.79 C

ATOM 2306 O VAL A 144 35.338 .047 -8.422 1.00 49.84 O

ATOM 2307 N SER A 145 35.723 8.445 -6.763 1.00 51.81 N

ATOM 2309 CA SER A 145 35.288 9.568 -7.616 1.00 54.78 C ATOM 2311 CB SER A 145 34.926 10.760 -6.750 1.00 54.47 C

ATOM 2314 OG SER A 145 34.427 11.741 -7.626 1.00 59.24 O

ATOM 2316 C SER A 145 36.287 9.966 -8.735 1.00 56.23 C

ATOM 2317 O SER A 145 37.469 10.176 -8.515 1.00 55.05 O

ATOM 2318 N SER A 146 35.814 10.152 -9.935 1.00 58.67 N

ATOM 2320 CA SER A 146 36.764 10.567 -10.927 1.00 61.98 C

ATOM 2322 CB SER A 146 36.061 10.701 -12.244 1.00 65.22 C

ATOM 2325 OG SER A 146 35.229 11.815 -12.148 1.00 69.73 O

ATOM 2327 C SER A 146 37.586 11.851 -10.591 1.00 63.73 C

ATOM 2328 O SER A 146 38.718 12.001 -11.061 1.00 66.06 O

ATOM 2329 N ASP A 147 37.110 12.782 -9.776 1.00 63.35 N

ATOM 2331 CA ASP A 147 38.047 13.855 -9.448 1.00 64.51 C

ATOM 2333 CB ASP A 147 37.388 14.938 -8.643 1.00 65.88 C

ATOM 2336 CG ASP A 147 36.191 15.484 -9.315 1.00 70.56 C

ATOM 2337 ODl ASP A 147 36.324 15.944 -10.449 1.00 76.86 O

ATOM 2338 OD2 ASP A 147 35.062 15.475 -8.799 1.00 74.60 O

ATOM 2339 C ASP A 147 39.320 13.451 -8.694 1.00 61.87 C

ATOM 2340 O ASP A 147 40.181 14.271 -8.574 1.00 64.00 O

ATOM 2341 N PHE A 148 39.443 12.235 -8.160 1.00 58.00 N

ATOM 2343 CA PHE A 148 40.589 11.831 -7.323 1.00 55.65 C

ATOM 2345 CB PHE A 148 40.100 11.392 -5.912 1.00 52.67 C

ATOM 2348 CG PHE A 148 39.418 12.463 -5.124 1.00 52.51 C

ATOM 2349 CDl PHE A 148 38.059 12.760 -5.313 1.00 55.87 C

ATOM 2351 CEl PHE A 148 37.408 13.812 -4.627 1.00 53.04 C

ATOM 2353 CZ PHE A 148 38.100 14.471 -3.764 1.00 53.77 C

ATOM 2355 CE2 PHE A 148 39.466 14.202 -3.553 1.00 50.27 C

ATOM 2357 CD2 PHE A 148 40.105 13.203 -4.221 1.00 53.15 C

ATOM 2359 C PHE A 148 41.411 10.674 -7.958 1.00 55.84 C

ATOM 2360 O PHE A 148 42.390 10.172 -7.375 1.00 54.76 O

ATOM 2361 N LEU A 149 40.992 10.208 -9.141 1.00 57.46 N

ATOM 2363 CA LEU A 149 41.756 9.207 -9.902 1.00 57.20 C

ATOM 2365 CB LEU A 149 41.124 8.951 -11.285 1.00 58.59 C

ATOM 2368 CG LEU A 149 39.781 8.163 -11.362 1.00 57.42 C

ATOM 2370 CDl LEU A 149 39.542 7.556 -12.713 1.00 59.65 C

ATOM 2374 CD2 LEU A 149 39.590 7.015 -10.313 1.00 54.35 C

ATOM 2378 C LEU A 149 43.154 9.743 -10.028 1.00 59.44 C

ATOM 2379 O LEU A 149 44.122 9.110 -9.706 1.00 57.88 O

ATOM 2380 N SER A 150 43.237 10.997 -10.427 1.00 63.31 N

ATOM 2382 CA SER A 150 44.517 11.658 -10.439 1.00 65.95 C

ATOM 2384 CB SER A 150 44.345 13.107 -10.848 1.00 69.04 C

ATOM 2387 OG SER A 150 44.468 13.155 -12.260 1.00 74.02 O

ATOM 2389 C SER A 150 45.359 11.553 -9.165 1.00 64.15 C

ATOM 2390 O SER A 150 46.550 11.630 -9.276 1.00 66.94 O

ATOM 2391 N ASN A 151 44.802 11.413 -7.962 1.00 60.55 N

ATOM 2393 CA ASN A 151 45.676 11.373 -6.785 1.00 59.05 C

ATOM 2395 CB ASN A 151 45.280 12.526 -5.824 1.00 58.72 C

ATOM 2398 CG ASN A 151 45.979 13.869 -6.202 1.00 65.21 C

ATOM 2399 ODl ASN A 151 45.616 14.591 -7.128 1.00 66.28 O

ATOM 2400 ND2 ASN A 151 47.026 14.157 -5.506 1.00 72.90 N

ATOM 2403 C ASN A 151 45.879 9.943 -6.181 1.00 55.44 C

ATOM 2404 O ASN A 151 46.471 9.774 -5.128 1.00 53.43 O

ATOM 2405 N MET A 152 45.499 8.901 -6.932 1.00 54.65 N

ATOM 2407 CA MET A 152 45.653 7.496 -6.467 1.00 52.66 C

ATOM 2409 CB MET A 152 44.910 6.533 -7.366 1.00 51.86 C

ATOM 2412 CG MET A 152 43.443 6.813 -7.552 1.00 52.03 C

ATOM 2415 SD MET A 152 42.338 6.049 -6.388 1.00 50.06 S

ATOM 2416 CE MET A 152 42.743 4.273 -6.557 1.00 48.82 C

ATOM 2420 C MET A 152 47.124 7.024 -6.371 1.00 54.06 C

ATOM 2421 O MET A 152 47.951 7.492 -7.134 1.00 56.68 O

ATOM 2422 N SER A 153 47.449 6.144 -5.399 1.00 52.56 N

ATOM 2424 CA SER A 153 48.828 5.589 -5.246 1.00 54.12 C

ATOM 2426 CB SER A 153 49.601 6.341 -4.187 1.00 54.43 C

ATOM 2429 OG SER A 153 50.968 6.247 -4.512 1.00 56.90 O

ATOM 2431 C SER A 153 48.953 4.069 -4.949 1.00 52.77 C

ATOM 2432 O SER A 153 49.268 3.659 -3.817 1.00 52.35 O

ATOM 2433 N MET A 154 48.749 3.276 -5.995 1.00 52.33 N

ATOM 2435 CA MET A 154 48.550 1.862 -5.893 1.00 50.75 C

ATOM 2437 CB MET A 154 47.455 1.440 -6.811 1.00 49.97 C ATOM 2440 CG MET A 154 46.216 2.318 -6.656 1..00 50.89 C

ATOM 2443 SD MET A 154 45.282 1.929 148 1..00 58.01 S

ATOM 2444 CE MET A 154 45.749 3.387 448 1..00 57.15 C

ATOM 2448 C MET A 154 49.802 1.157 -6.255 1..00 52.92 C

ATOM 2449 O MET A 154 50.276 1.278 -7 330 1..00 54.18 O

ATOM 2450 N ASP A 155 50.346 0.414 5.315 1..00 53.59 N

ATOM 2452 CA ASP A 155 51.559 -0.296 ^■5.564 1..00 57.73 C

ATOM 2454 CB ASP A 155 52.786 0.526 ^■5.195 1..00 60.70 C

ATOM 2457 CG ASP A 155 54.088 -0.300 5.273 1..00 67.99 C

ATOM 2458 ODl ASP A 155 54.469 -0.830 6.389 1..00 70.11 O

ATOM 2459 OD2 ASP A 155 54.773 -0.487 4.215 1..00 74.44 O

ATOM 2460 C ASP A 155 51.489 -1.670 4.882 1..00 56.85 C

ATOM 2461 O ASP A 155 51.675 -1.845 3.662 1..00 55.16 O

ATOM 2462 N PHE A 156 51.232 -2.651 -5.733 1.00 57.62 N

ATOM 2464 CA PHE A 156 50.904 -3.965 -5.298 1.00 57.25 C

ATOM 2466 CB PHE A 156 49.701 -4.410 -6.080 .00 55.63 C

ATOM 2469 CG PHE A 156 48.424 -3.817 -5.645 .00 51.82 C

ATOM 2470 CDl PHE A 156 47.824 -2.852 -6.408 .00 48.57 C

ATOM 2472 CEl PHE A 156 46.643 -2.329 -6.067 .00 48.09 C

ATOM 2474 CZ PHE A 156 46.005 -2.746 -4 921 00 49.29 C

ATOM 2476 CE2 PHE A 156 46.573 -3.759 •4.128 00 49.85 C

ATOM 2478 CD2 PHE A 156 47.775 -4.298 ^•4.513 00 51.25 C

ATOM 2480 C PHE A 156 52.031 -4.922 ^■5.663 00 62.02 C

ATOM 2481 O PHE A 156 52.258 -5.121 6.862 00 65.96 O

ATOM 2482 N GLN A 157 52.711 -5.558 4.693 00 63.64 N

ATOM 2484 CA GLN A 157 53.730 -6.585 ^■5.019 00 67.83 C

ATOM 2486 CB GLN A 157 55.158 -6.019 ^•5.121 1.00 71.20 C

ATOM 2489 CG GLN A 157 55.232 -4.741 ■5.955 00 74.76 C

ATOM 2492 CD GLN A 157 56.512 -3.922 5.738 00 81.43 C

ATOM 2493 OEl GLN A 157 57.596 -4.501 5.524 00 84.93 O

ATOM 2494 NE2 GLN A 157 56.394 -2.570 5.832 00 80.80 N

ATOM 2497 C GLN A 157 53.694 -7.701 ^■3.995 1.00 67.85 C

ATOM 2498 O GLN A 157 54.239 -7.549 •2.884 00 68.89 O

ATOM 2499 N ASN A 158 53.049 -8.824 ^■4.343 00 67.34 N

ATOM 2501 CA ASN A 158 52.985 -9.931 3.387 00 66.37 C

ATOM 2503 CB ASN A 158 51.748 -10.825 ■3.573 00 65.25 C

ATOM 2506 CG ASN A 158 51.555 -11.805 -2 408 00 65.80 C

ATOM 2507 ODl ASN A 158 52.434 -12.615 -2.126 1.00 69.30 O

ATOM 2508 ND2 ASN A 158 50.396 -11.749 -1.760 .00 62.84 N

ATOM 2511 C ASN A 158 54.252 -10.683 -3.607 .00 68.88 C

ATOM 2512 O ASN A 158 54.482 -11.075 -4.714 .00 71.15 O

ATOM 2513 N HIS A 159 55.079 -10.768 -2.562 .00 68.92 N

ATOM 2515 CA HIS A 159 56.367 -11.474 -2.511 .00 72.75 C

ATOM 2517 CB HIS A 159 57.529 -10.454 -2.416 .00 74.34 C

ATOM 2525 C HIS A 159 56.430 -12.503 -1.321 1.00 73.55 C

ATOM 2526 O HIS A 159 57.483 -13.106 -1.060 1.00 77.25 O

ATOM 2527 N LEϋ A 160 55.312 -12.726 -0.620 1.00 70.71 N

ATOM 2529 CA LEU A 160 55.300 -13.613 0.558 .00 71.96 C

ATOM 2531 CB LEϋ A 160 54.955 -12.858 1.835 .00 69.16 C

ATOM 2534 CG LEU A 160 56.170 -12.018 2.242 .00 72.49 C

ATOM 2536 CDl LEU A 160 55.879 -11.038 3.417 .00 70.29 C

ATOM 2540 CD2 LEU A 160 57.406 -12.963 2.560 .00 78.18 C

ATOM 2544 C LEU A 160 54.436 -14.860 0.466 .00 72.80 C

ATOM 2545 O LEU A 160 54.715 -15.905 1.146 .00 76.27 O

ATOM 2546 N GLY A 161 53.426 -14.830 -0.387 1.00 70.92 N

ATOM 2548 CA GLY A 161 52.682 -16.052 -0.588 1.00 71.53 C

ATOM 2551 C GLY A 161 52.337 -16.324 -2 010 1.00 72.10 C

ATOM 2552 O GLY A 161 52.925 -15.725 •2.936 1.00 73.91 O

ATOM 2553 N SER A 162 51.354 -17.218 ■2.151 1.00 71.50 N

ATOM 2555 CA SER A 162 50.850 -17.612 -3.430 .00 71.80 C

ATOM 2557 CB SER A 162 51.072 -19.072 -3.631 .00 75.27 C

ATOM 2560 OG SER A 162 49.976 -19.671 -3.029 .00 75.08 O

ATOM 2562 C SER A 162 49.382 -17.287 -3.697 .00 68.40 C

ATOM 2563 O SER A 162 49.076 -17.118 -4.826 .00 71.58 O

ATOM 2564 N CYS A 163 48.443 -17.195 -2.785 .00 64.77 N

ATOM 2566 CA CYS A 163 47.190 -16.558 -3 248 1.00 62.32 C

ATOM 2568 CB CYS A 163 47.482 -15.350 4.121 1.00 60.54 C

ATOM 2571 SG CYS A 163 48.195 -14.039 3.164 1.00 65.07 S ATOM 2572 C CYS A 163 46.203 -17.327 -4.092 1.00 62.09 C ATOM 2573 O CYS A 163 46.486 -17.842 -5.125 1.00 64.63 O ATOM 2574 N GLN A 164 44.966 -17.252 -3.712 1.00 59.87 N ATOM 2576 CA GLN A 164 43.963 -17.875 -4.490 1.00 59.87 C ATOM 2578 CB GLN A 164 42.775 -18.151 -3.577 1.00 58.78 C ATOM 2581 CG GLN A 164 43.135 -19.114 -2.394 1.00 60.45 C ATOM 2584 CD GLN A 164 42.289 -18.848 -1.173 1.00 58.32 C ATOM 2585 OEl GLN A 164 41.246 -19.446 -1.065 1.00 62.19 O ATOM 2586 NE2 GLN A 164 42.706 -17.902 -0.272 00 60.77 N ATOM 2589 C GLN A 164 43.615 -17.003 -5.717 1.00 58.68 C ATOM 2590 O GLN A 164 44.054 -15.875 -5.910 1.00 55.31 O ATOM 2591 N LYS A 165 42.840 -17.597 -6.587 1.00 60.41 N ATOM 2593 CA LYS A 165 42.374 -16.938 -7.780 00 59.80 C ATOM 2595 CB LYS A 165 42.587 -17.888 -8.966 00 63.00 C ATOM 2598 CG LYS A 165 44.023 -18.081 -9.347 00 64.02 C ATOM 2601 CD LYS A 165 44.046 -18.676 -10.685 00 70.24 C ATOM 2604 CE LYS A 165 45.354 -19.359 -10.979 1.00 75.93 C ATOM 2607 NZ LYS A 165 45.322 -20.005 -12.321 00 78.93 N ATOM 2611 C LYS A 165 -7..632 00 57.91 C ATOM 2612 O LYS A 165 40.082 -17.115 -6.894 00 57.15 O ATOM 2613 N CYS A 166 40.574 -15.429 -8.331 00 56.63 N ATOM 2615 CA CYS A 166 39.229 -14.949 -8.421 00 56.14 C ATOM 2617 CB CYS A 166 39.265 -13.725 -9.280 1.00 56.07 C ATOM 2620 SG CYS A 166 39.966 -12.314 -8.384 ,00 60.17 S ATOM 2621 C CYS A 166 38.278 -15.928 -9.059 .00 58.20 C ATOM 2622 O CYS A 166 38.612 -16.593 -9.993 ,00 60.87 O ATOM 2623 N ASP A 167 37.054 -15.995 -8.604 1.00 58.01 N ATOM 2625 CA ASP A 167 36.071 -16.803 -9.313 1.00 62.21 C ATOM 2627 CB ASP A 167 34.731 -16.757 -8.577 1.00 61.75 C ATOM 2630 CG ASP A 167 33.981 -18.042 -8.691 1.00 67.21 C ATOM 2631 ODl ASP A 167 33.252 -18.146 -9.682 1.00 71.66 O ATOM 2632 OD2 ASP A 167 34.098 -19.030 -7.887 1.00 71.36 O ATOM 2633 C ASP A 167 35.907 -16.370 -10.772 1.00 64.34 C ATOM 2634 O ASP A 167 35.932 -15.189 -11.077 1.00 64.04 O ATOM 2635 N PRO A 168 35.733 -17.276 -11.712 1.00 69.18 N ATOM 2636 CA PRO A 168 35.529 -16.843 -13.117 1.00 71.67 C ATOM 2638 CB PRO A 168 35.482 -18.135 -13.880 1.00 75.31 C ATOM 2641 CG PRO A 168 34.937 -19.094 -12.867 1.00 75.75 C ATOM 2644 CD PRO A 168 35.648 -18.736 -11.577 1.00 72.39 C ATOM 2647 C PRO A 168 34.190 -16.113 -13.277 1.00 72.13 C ATOM 2648 O PRO A 168 33.980 -15.434 -14.273 1.00 74.17 O ATOM 2649 N SER A 169 33.333 -16.243 -12.263 1.00 70.78 N ATOM 2651 CA SER A 169 32.029 -15.649 -12.196 1.00 70.36 C ATOM 2653 CB SER A 169 31.448 -16.185 -10.906 1.00 69.09 C ATOM 2656 OG SER A 169 30.162 -15.740 -10.627 1.00 69.59 O ATOM 2658 C SER A 169 32.176 -14.099 -12.189 1.00 68.96 C ATOM 2659 O SER A 169 31.369 -13.354 -12.767 1.00 69.80 O ATOM 2660 N CYS A 170 33.235 -13.645 -11.522 1.00 66.34 N ATOM 2662 CA CYS A 170 33.585 -12.257 -11.389 1.00 64.17 C ATOM 2664 CB CYS A 170 35.009 -12.194 -10.803 1.00 62.64 C ATOM 2667 SG CYS A 170 35.099 -12.706 -9.064 1.00 65.28 S ATOM 2668 C CYS A 170 33.626 -11.532 -12.691 1.00 64.97 C ATOM 2669 O CYS A 170 34.036 -12.154 -13.644 1.00 67.60 O ATOM 2670 N PRO A 171 33.293 -10.224 -12.709 1.00 63.33 N ATOM 2671 CA PRO A 171 33.587 -9.309 -13.840 1.00 63.95 C ATOM 2673 CB PRO A 171 32.709 -8.083 -13.545 1.00 62.43 C ATOM 2676 CG PRO A 171 32.618 -8.081 -12.137 1.00 60.40 C ATOM 2679 CD PRO A 171 32.609 -9.504 -11.624 1.00 60.72 C ATOM 2682 C PRO A 171 35.056 -8.844 -13.952 1.00 62.28 C ATOM 2683 O PRO A 171 35.613 -8.339 -12.977 1.00 58.36 O ATOM 2684 N ASN A 172 35.651 -9.053 -15.137 1.00 64.60 N ATOM 2686 CA ASN A 172 37.014 -8.626 -15.469 1.00 64.03 C ATOM 2688 CB ASN A 172 37.092 -7.107 -15.494 1.00 63.31 C ATOM 2691 CG ASN A 172 36.067 -6.493 -16.417 1.00 64.86 C ATOM 2692 ODl ASN A 172 36.063 -6.769 -17.588 1.00 68.52 O ATOM 2693 ND2 ASN A 172 35.183 -5.689 -15.884 1.00 63.98 N ATOM 2696 C ASN A 172 38.072 -9.188 -14.525 1.00 62.11 C ATOM 2697 O ASN A 172 39.141 -8.611 -14.391 1.00 60.44 O ATOM 2698 N GLY A 173 37.760 -10.330 -13.891 1.00 61.90 N

ATOM 2700 CA GLY A 173 38.676 -11.067 -13.029 1.00 60.44 C

ATOM 2703 C GLY A 173 38.962 -10.365 -11.733 1.00 56.68 C

ATOM 2704 O GLY A 173 39.958 -10.665 -11.056 1.00 54.88 O

ATOM 2705 N SER A 174 38.081 -9.436 -11.392 1.00 54.92 N

ATOM 2707 CA SER A 174 38.350 -8.556 -10.289 1.00 53.27 C

ATOM 2709 CB SER A 174 38.094 -7.084 -10.657 1.00 54.14 C

ATOM 2712 OG SER A 174 37.408 -6.922 -11.890 1.00 61.12 O

ATOM 2714 C SER A 174 37.560 -8.949 -9.069 1.00 51.33 C

ATOM 2715 O SER A 174 36.354 -9.118 -9.128 1.00 51.96 O

ATOM 2716 N CYS A 175 38.277 -9.140 -7.965 1.00 50.14 N

ATOM 2718 CA CYS A 175 37.716 -9.660 -6.724 1.00 49.06 C

ATOM 2720 CB CYS A 175 37.668 -11.161 -6.785 1.00 51.08 C

ATOM 2723 SG CYS A 175 39.237 -11.989 -6.497 1.00 54.98 S

ATOM 2724 C CYS A 175 38.552 -9.228 -5.541 1.00 46.28 C

ATOM 2725 O CYS A 175 39.663 -8.727 -5.713 1.00 45.60 O

ATOM 2726 N TRP A 176 38.009 -9.415 -4.342 1.00 44.79 N

ATOM 2728 CA TRP A 176 38.693 -9.052 -3.078 1.00 42.74 C

ATOM 2730 CB TRP A 176 37.714 -8.389 -2.131 1.00 40.96 C

ATOM 2733 CG TRP A 176 37.119 -7.038 -2.642 1.00 40.42 C

ATOM 2734 CDl TRP A 176 35.982 -6.870 -3.326 1.00 39.92 C

ATOM 2736 NEl TRP A 176 35.755 -5.544 -3..560 1.00 41.12 N

ATOM 2738 CE2 TRP A 176 36.782 -4.827 -3..009 1.00 41.59 C

ATOM 2739 CD2 TRP A 176 37.639 -5.735 -2.393 1.00 38.66 C

ATOM 2740 CE3 TRP A 176 38.790 -5.256 -1.764 1.00 39.18 C

ATOM 2742 CZ3 TRP A 176 39.040 -3.931 -1.766 1.00 36.89 C

ATOM 2744 CH2 TRP A 176 38.161 -3.054 -2.364 1.00 40.57 C

ATOM 2746 CZ2 TRP A 176 37.023 -3.483 -3.010 1.00 40.72 C

ATOM 2748 C TRP A 176 39.264 -10.290 -2.369 1.00 43.56 C

ATOM 2749 O TRP A 176 39.952 -10.188 -1.370 1.00 42.95 O

ATOM 2750 N GLY A 177 38.981 -11.465 -2.907 1.00 45.37 N

ATOM 2752 CA GLY A 177 39.457 -12.658 -2.312 1.00 45.99 C

ATOM 2755 C GLY A 177 38.797 -13.810 -2.985 1.00 49.26 C

ATOM 2756 O GLY A 177 38.184 -13.706 -4.041 1.00 50.81 O

ATOM 2757 N ALA A 178 38.914 -14.939 -2.328 1.00 50.26 N

ATOM 2759 CA ALA A 178 38.527 -16.179 -2.908 1.00 53.28 C

ATOM 2761 CB ALA A 178 39.129 -17.222 -2.129 1.00 55.32 C

ATOM 2765 C ALA A 178 37.029 -16.275 -2.878 1.00 53.36 C

ATOM 2766 O ALA A 178 36.440 -15.593 -2.110 1.00 50.54 O

ATOM 2767 N GLY A 179 36.414 -17.067 -3.747 1.00 55.92 N

ATOM 2769 CA GLY A 179 34.974 -17.248 -3.736 1.00 57.34 C

ATOM 2772 C GLY A 179 34.100 -16.268 -4.495 1.00 56.65 C

ATOM 2773 O GLY A 179 34.480 -15.136 -4.759 1.00 53.03 O

ATOM 2774 N GLD A 180 32.925 -16.772 -4.873 1.00 59.51 N

ATOM 2776 CA GLU A 180 31.983 -16.075 -5.712 1.00 60.69 C

ATOM 2778 CB GLϋ A 180 30.822 -16.977 -6.100 1.00 64.23 C

ATOM 2781 CG GLU A 180 30.038 -16.423 -7.273 1.00 69.05 C

ATOM 2784 CD GLU A 180 28.984 -17.373 -7.882 1.00 79.34 C

ATOM 2785 OEl GLU A 180 27.807 -16.913 -7.924 1.00 83.24 O

ATOM 2786 OE2 GLU A 180 29.287 -18.553 -8.346 1.00 85.62 O

ATOM 2787 C GLU A 180 31.425 -14.874 -4.965 1.00 58.20 C

ATOM 2788 O GLU A 180 31.056 -13.872 -5.585 1.00 55.67 O

ATOM 2789 N GLU A 181 31.338 -15.008 -3.639 1.00 57.72 N

ATOM 2791 CA GLU A 181 30.851 -13.919 -2.784 1.00 56.13 C

ATOM 2793 CB GLU A 181 30.543 -14.432 -1.393 1.00 56.53 C

ATOM 2796 CG GLU A 181 31.761 -14.311 -0.500 1.00 56.15 C

ATOM 2799 CD GLU A 181 31.764 -15.221 0.695 1.00 58.93 C

ATOM 2800 OEl GLU A 181 30.689 -15.799 0.952 1.00 63.12 O

ATOM 2801 OE2 GLU A 181 32.849 -15.341 1..348 1.00 58.06 O

ATOM 2802 C GLU A 181 31.802 -12.698 -2,,640 1.00 52.53 C

ATOM 2803 O GLU A 181 31.385 -11.655 -2.106 1.00 51.74 O

ATOM 2804 N ASN A 182 33.061 -12.845 -3.073 1.00 51.13 N

ATOM 2806 CA ASN A 182 34.102 -11.813 -2.936 1.00 47.84 C

ATOM 2808 CB ASN A 182 35.396 -12.431 -2.392 1.00 46.56 C

ATOM 2811 CG ASN A 182 35.351 -12.667 -0.891 1.00 46.60 C

ATOM 2812 ODl ASN A 182 34.761 -11.922 -0.093 1.00 45.34 O

ATOM 2813 ND2 ASN A 182 36.004 -13.707 -0.499 1.00 47.84 N

ATOM 2816 C ASN A 182 34.383 -11.183 -4.272 1.00 Al.11 C ATOM 2817 O ASN A 182 35.383 -10.470 -4.441 1.00 45.91 O

ATOM 2818 N CYS A 183 33.503 -11.480 -5.236 1.00 50.13 N

ATOM 2820 CA CYS A 183 33.545 -10.849 -6.567 1.00 51.09 C

ATOM 2822 CB CYS A 183 32.578 -11.504 -7.579 1.00 53.48 C

ATOM 2825 SG CYS A 183 33.164 -13.146 -8.334 1.00 63.64 S

ATOM 2826 C CYS A 183 33.204 -9.376 -6.289 1.00 48.00 C

ATOM 2827 O CYS A 183 32.345 -9.091 -5.454 1.00 45.84 O

ATOM 2828 N GLN A 184 33.937 -8.507 -6.987 1.00 46.92 N

ATOM 2830 CA GLN A 184 33.621 -7.097 -7.082 1.00 47.29 C

ATOM 2832 CB GLN A 184 34.702 -6.286 -7.837 1.00 45.60 C

ATOM 2835 CG GLN A 184 34.313 -4.821 -8.086 1.00 46.53 C

ATOM 2838 CD GLN A 184 35.490 -3.732 -8.235 1.00 45.39 C

ATOM 2839 OEl GLN A 184 36.557 -3.993 -8.815 1.00 43.19 O

ATOM 2840 NE2 GLN A 184 35.226 -2.509 -7..721 1.00 41.52 N

ATOM 2843 C GLN A 184 32.209 -6.922 -7..643 1.00 49.85 C

ATOM 2844 O GLN A 184 31.887 -7.418 -8.732 1.00 53.03 O

ATOM 2845 N LYS A 185 31.342 -6.271 -6.868 1.00 49.27 N

ATOM 2847 CA LYS A 185 30.086 -5.798 -7.441 1.00 51.63 C

ATOM 2849 CB LYS A 185 29.023 -5.620 -6.343 1.00 52.06 C

ATOM 2852 CG LYS A 185 28.517 -6.901 -5.629 1.00 53.93 C

ATOM 2855 CD LYS A 185 28.156 -6.583 -4.065 1.00 53.03 C

ATOM 2858 CE LYS A 185 28.695 -7.612 -3..059 1.00 49.07 C

ATOM 2861 NZ LYS A 185 27.572 -8.323 -2..540 1.00 54.03 N

ATOM 2865 C LYS A 185 30.318 -4.457 -8.218 1.00 50.18 C

ATOM 2866 O LYS A 185 30.983 -3.581 -7.726 1.00 49.13 O

ATOM 2867 N LEU A 186 29.780 -4 279 -9.412 1.00 52.33 N

ATOM 2869 CA LEU A 186 29.967 -3.001 -10.114 1.00 52.28 C

ATOM 2871 CB LEU A 186 30.613 -3.131 -11.493 1.00 53.18 C

ATOM 2874 CG LEU A 186 32.019 -3.758 -11.492 1.00 52.36 C

ATOM 2876 CDl LEU A 186 32.537 -4.107 -12.914 1.00 54.00 C

ATOM 2880 CD2 LEU A 186 33.021 -2 930 -10.768 00 48.37 C

ATOM 2884 C LEU A 186 28.654 -2.280 -10.199 1.00 54.66 C

ATOM 2885 O LEU A 186 27.611 -2.903 -10.407 1.00 56.57 O

ATOM 2886 N THR A 187 28.725 -0.964 -9.972 1.00 54.57 N

ATOM 2888 CA THR A 187 27.587 -0.095 -10.035 1.00 57.60 C

ATOM 2890 CB THR A 187 27.054 0.099 -8.609 1.00 56.84 C

ATOM 2892 OGl THR A 187 28.131 0.506 -7.763 1.00 56.81 O

ATOM 2894 CG2 THR A 187 26.549 •1.189 -7.960 1.00 55.84 C

ATOM 2898 C THR A 187 27.833 1.310 -10.662 1.00 59.12 C

ATOM 2899 O THR A 187 26.885 2.106 -10.684 1.00 60.17 O

ATOM 2900 N LYS A 188 29.051 1.629 -11.153 1.00 59.07 N

ATOM 2902 CA LYS A 188 29.350 2.969 -11.776 1.00 60.11 C

ATOM 2904 CB LYS A 188 30.430 3.762 -10.957 1.00 57.60 C

ATOM 2907 CG LYS A 188 30.704 5.336 -11.208 1.00 53.08 C

ATOM 2910 CD LYS A 188 31.704 6.033 -10.139 1.00 50.46 C

ATOM 2913 CE LYS A 188 32.508 7.420 -10.695 1.00 62.36 C

ATOM 2916 NZ LYS A 188 32.092 9.158 -10.925 1.00 56.57 N

ATOM 2920 C LYS A 188 29.771 2.735 -13.239 1.00 63.34 C

ATOM 2921 O LYS A 188 29.111 3.149 -14.157 1.00 66.50 O

ATOM 2922 N ILE A 189 30.843 1.998 -13.440 1.00 63.68 N

ATOM 2924 CA ILE A 189 31.424 1.690 -14.765 1.00 67.03 C

ATOM 2926 CB ILE A 189 32.738 0.990 -14.377 1.00 65.88 C

ATOM 2928 CGl ILE A 189 33.814 2.078 -14.376 1.00 68.15 C

ATOM 2931 CDl ILE A 189 34.948 1.628 -13.491 1.00 70.37 C

ATOM 2935 CG2 ILE A 189 33.099 -0.237 -15.182 1.00 66.88 C

ATOM 2939 C ILE A 189 30.607 0.832 -15.788 1.00 70.02 C

ATOM 2940 O ILE A 189 30.992 0.629 -16.920 1.00 72.11 O

ATOM 2941 N ILE A 190 29.476 0.336 -15.338 1.00 70.44 N

ATOM 2943 CA ILE A 190 28.701 -0.687 -15.994 1.00 72.98 C

ATOM 2945 CB ILE A 190 28.515 -1.794 -14.937 1.00 70.63 C

ATOM 2947 CGl ILE A 190 29.637 -2.783 -15.140 1.00 71.22 C

ATOM 2950 CDl ILE A 190 29.307 -4.255 -14.645 1.00 76.22 C

ATOM 2954 CG2 ILE A 190 27.125 -2.377 -14.917 1.00 71.99 C

ATOM 2958 C ILE A 190 27.366 -0.090 -16.413 1.00 76.24 C

ATOM 2959 O ILE A 190 26.564 -0.726 -17.119 1.00 79.79 O

ATOM 2960 N CYS A 191 27.136 1.143 -15.996 1.00 75.30 N

ATOM 2962 CA CYS A 191 25.844 1.785 -16.157 1.00 78.23 C

ATOM 2964 CB CYS A 191 25.752 2.923 -15.123 1.00 76.32 C ATOM 2967 SG CYS A 191 26.102 2.238 -13.446 1.00 74.45 S

ATOM 2968 C CYS A 191 25.605 2.255 ^■17.601 1.00 81.91 C

ATOM 2969 O CYS A 191 26.543 2.581 18.338 1.00 82.17 O

ATOM 2970 N ALA A 192 24.346 2.227 18.012 00 .89 N

ATOM 2972 CA ALA A 192 23.966 2.868 ^■19.251 00 .58 C

ATOM 2974 CB ALA A 192 22.450 2.842 ^•19.400 1.00 93.30 C

ATOM 2978 C ALA A 192 24.506 4.339 19.275 1.00 89.64 C

ATOM 2979 O ALA A 192 24.639 4.980 ^•18.201 1.00 85.53 O

ATOM 2980 N GLN A 193 24.836 4.846 ^•20.484 1.00 93.10 N

ATOM 2982 CA GLN A 193 25.353 6.215 ^■20.616 1.00 94.09 C

ATOM 2984 CB GLN A 193 25.538 6.634 ^■22.098 1.00 99.22 C

ATOM 2987 CG GLN A 193 26.163 8.062 ^■22.297 1.00 99.92 C

ATOM 2990 CD GLN A 193 25.933 8.638 ^■23.692 1.00108.02 C

ATOM 2991 OEl GLN A 193 25.886 7.901 •24.675 1.00115.13 O

ATOM 2992 NE2 GLN A 193 25.800 9.955 ^•23.788 1.00112.64 N

ATOM 2995 C GLN A 193 24.388 7.177 •19.901 1.00 94.51 C

ATOM 2996 O GLN A 193 24.827 8.100 19.208 1.00 92.51 O

ATOM 2997 N GLN A 194 23.086 6.891 ^•20.050 1.00 97.35 N

ATOM 2999 CA GLN A 194 21.973 7.735 ^■19.591 1.00 99.21 C

ATOM 3001 CB GLN A 194 20.667 7.116 ^•20.142 1.00103.46 C

ATOM 3008 C GLN A 194 21.839 8.015 ^•18.057 1.00 95.71 C

ATOM 3009 O GLN A 194 21.013 8.809 ^■17.645 1.00 97.16 O

ATOM 3010 N CYS A 195 22.633 7.364 17.216 1.00 91.62 N

ATOM 3012 CA CYS A 195 22.490 7.526 ^■15.791 1.00 88.83 C

ATOM 3014 CB CYS A 195 22.917 6.292 ^■15.017 1.00 85.27 C

ATOM 3017 SG CYS A 195 21.902 4.815 ^■15.196 1.00 90.56 S

ATOM 3018 C CYS A 195 23.412 8.598 ^•15.346 1.00 86.94 C

ATOM 3019 O CYS A 195 24.607 8.599 15.680 1.00 85.07 O

ATOM 3020 N SER A 196 22.858 9.456 ^■14.507 1.00 87.22 N

ATOM 3022 CA SER A 196 23.627 10.438 13.814 1.00 85.77 C

ATOM 3024 CB SER A 196 22.648 11.354 ^■13.047 1.00 87.93 C

ATOM 3027 OG SER A 196 22.540 11.018 ^■11.651 1.00 86.76 O

ATOM 3029 C SER A 196 24.677 9.843 ^■12.839 1.00 81.16 C

ATOM 3030 O SER A 196 25.573 10.557 12.395 1.00 81.13 O

ATOM 3031 N GLY A 197 24.538 8.580 12.438 1.00 78.73 N

ATOM 3033 CA GLY A 197 25.334 8.000 ^■11.342 1.00 73.56 C

ATOM 3036 C GLY A 197 24.830 6.601 ^■11.007 1.00 72.09 C

ATOM 3037 O GLY A 197 23.864 6.111 -11 623 1.00 75.94 O

ATOM 3038 N ARG A 198 25.480 5.936 -10.068 1.00 67.34 N

ATOM 3040 CA ARG A 198 25.152 4.530 -9.712 1.00 65.41 C

ATOM 3042 CB ARG A 198 24.991 4.402 -8.192 1.00 63.68 C

ATOM 3045 CG ARG A 198 26.212 4.737 -7.348 1.00 57.45 C

ATOM 3048 CD ARG A 198 27.428 4.201 -7.931 1.00 54.35 C

ATOM 3051 NE ARG A 198 28.605 4.632 -7.227 1.00 49.75 N

ATOM 3053 CZ ARG A 198 29.670 3.892 -7. 060 1.00 48.00 C

ATOM 3054 NHl ARG A 198 29.696 2.647 -7.498 1.00 51.64 N

ATOM 3057 NH2 ARG A 198 30.717 4.384 -6.450 1.00 45.20 N

ATOM 3060 C ARG A 198 23.916 3.831 10.309 1.00 67.96 C

ATOM 3061 O ARG A 198 22.865 4.429 10.482 1.00 69.74 O

ATOM 3062 N CYS A 199 24.066 2.517 - 10.533 1.00 68.17 N

ATOM 3064 CA CYS A 199 22.980 1.584 ^•11.035 1.00 70.76 C

ATOM 3066 CB CYS A 199 23.028 1.453 12.552 1.00 73.17 C

ATOM 3069 SG CYS A 199 24.620 0.814 ^•13.123 1.00 70.86 S

ATOM 3070 C CYS A 199 23.083 0.184 •10.385 1.00 68.65 C

ATOM 3071 O CYS A 199 23.915 -0.044 -9.450 1.00 65.70 O

ATOM 3072 N ARG A 200 22.214 -0.730 ^■10.837 1.00 70.83 N

ATOM 3074 CA ARG A 200 22.179 -2.148 ^•10.359 1.00 69.39 C

ATOM 3076 CB ARG A 200 21.098 -2.232 -9.299 1.00 70.45 C

ATOM 3079 CG ARG A 200 19.798 -1.633 -9.740 1.00 73.74 C

ATOM 3082 CD ARG A 200 18.746 -1.838 -8.754 1.00 76.36 C

ATOM 3085 NE ARG A 200 17.429 -1.744 -9.348 1.00 82.84 N

ATOM 3087 CZ ARG A 200 16.411 -2.522 -9.015 1.00 86.81 C

ATOM 3088 NHl ARG A 200 16.540 -3.467 -8.083 1.00 85.55 N

ATOM 3091 NH2 ARG A 200 15.245 -2.346 -9.616 1.00 92.94 N

ATOM 3094 C ARG A 200 21.932 -3.214 ^■11.467 1.00 71.45 C

ATOM 3095 O ARG A 200 21.777 -4.416 11.236 1.00 71.97 O

ATOM 3096 N GLY A 201 21.869 -2.714 ^■12.673 1.00 73.31 N

ATOM 3098 CA GLY A 201 21.586 -3.476 ^■13.847 1.00 77.37 C ATOM 3101 C GLY A 201 22.227 -2.705 -14.954 1.00 78.01 C

ATOM 3102 O GLY A 201 22.616 -1.565 -14.732 1.00 76.98 O

ATOM 3103 N LYS A 202 22.386 -3.322 -16.117 1.00 80.54 N

ATOM 3105 CA LYS A 202 23.135 -2.699 -17.185 1.00 81.72 C

ATOM 3107 CB LYS A 202 23.959 -3.720 -18.012 1.00 81.81 C

ATOM 3114 C LYS A 202 22.129 -1.884 -17.999 1.00 86.87 C

ATOM 3115 O LYS A 202 22.526 -1.153 -18.906 1.00 88.82 O

ATOM 3116 N SER A 203 20.842 -1.953 -17.613 1.00 89.89 N

ATOM 3118 CA SER A 203 19.704 -1.280 -18.316 1.00 94.97 C

ATOM 3120 CB SER A 203 18.414 -2.065 -18.031 1.00 98.06 C

ATOM 3123 OG SER A 203 18.209 -2.178 -16.619 1.00 96.46 O

ATOM 3125 C SER A 203 19.442 0.215 -17.938 1.00 94.60 C

ATOM 3126 O SER A 203 19.990 0.716 -16.921 1.00 89.96 O

ATOM 3127 N PRO A 204 18.628 0.908 -18.767 1.00 99.08 N

ATOM 3128 CA PRO A 204 18.061 2.235 -18.420 1.00 99.90 C

ATOM 3130 CB PRO A 204 17.375 2.695 -19.710 1.00105.95 C

ATOM 3133 CG PRO A 204 17.293 1.497 -20.624 1.00108.00 C

ATOM 3136 CD PRO A 204 18.277 0.493 -20.142 1.00103.68 C

ATOM 3139 C PRO A 204 17.048 2.246 -17.273 1.00100.16 C

ATOM 3140 O PRO A 204 17.060 3.133 -16.434 1.00 98.31 O

ATOM 3141 N SER A 205 16.173 1.267 -17.206 1.00102.97 N

ATOM 3143 CA SER A 205 15.376 1.118 -15.992 1.00103.18 C

ATOM 3145 CB SER A 205 14.395 -0.004 -16.148 1.00107.04 C

ATOM 3148 OG SER A 205 15.123 -1.122 -16.565 1.00106.57 O

ATOM 3150 C SER A 205 16.237 0.823 -14.770 1.00 97.64 C

ATOM 3151 O SER A 205 15.875 1.164 -13.651 1.00 97.84 O

ATOM 3152 N ASP A 206 17.401 0.227 -14.948 1.00 94.14 N

ATOM 3154 CA ASP A 206 18.244 -0.075 -13.781 1.00 88.73 C

ATOM 3156 CB ASP A 206 19.266 -1.183 -14.155 1.00 86.17 C

ATOM 3162 C ASP A 206 18.926 1.144 -13.099 1.00 84.68 C

ATOM 3163 O ASP A 206 19.810 0.969 -12.300 1.00 80.94 O

ATOM 3164 N CYS A 207 18.545 2.373 -13.378 1.00 86.84 N

ATOM 3166 CA CYS A 207 19.279 3.512 -12.786 1.00 84.84 C

ATOM 3168 CB CYS A 207 19.006 4.782 -13.567 1.00 88.15 C

ATOM 3171 SG CYS A 207 19.830 4.949 -15.177 1.00 93.16 S

ATOM 3172 C CYS A 207 18.945 3.809 -11.311 1.00 82.80 C

ATOM 3173 O CYS A 207 17.821 3.524 -10.885 1.00 85.48 O

ATOM 3174 N CYS A 208 19.915 4.385 -10.561 1.00 78.90 N

ATOM 3176 CA CYS A 208 19.749 4.786 -9.117 1.00 76.99 C

ATOM 3178 CB CYS A 208 20.959 4.473 -8.200 1.00 71.82 C

ATOM 3181 SG CYS A 208 21.335 2.712 -7.852 1.00 71.46 S

ATOM 3182 C CYS A 208 19.496 6.275 -9.006 1.00 77.75 C

ATOM 3183 O CYS A 208 20.107 7.074 -9.710 1.00 76.69 O

ATON 3184 N HIS A 209 18.607 6.637 -8.092 1.00 79.28 N

ATOM 3186 CA HIS A 209 18.280 8.040 -7.879 1.00 81.28 C

ATOM 3188 CB HIS A 209 17.372 8.223 -6.680 1.00 82.57 C

ATOM 3191 CG HIS A 209 16.907 9.628 -6.497 1.00 86.38 C

ATOM 3192 NDl HIS A 209 15.853 10.170 -7.198 1.00 94.24 N

ATOM 3194 CEl HIS A 209 15.655 11.421 -6.809 1.00 96.56 C

ATOM 3196 NE2 HIS A 209 16.568 11.718 -5.902 1.00 91.93 N

ATOM 3198 CD2 HIS A 209 17.357 10.610 -5.691 1.00 86.90 C

ATOM 3200 C HIS A 209 19.551 8.845 -7.694 1.00 78.10 C

ATOM 3201 O HIS A 209 20.510 8.343 -7.144 1.00 73.89 O

ATOM 3202 N ASN A 210 19.543 10.089 -8.168 1.00 80.56 N

ATOM 3204 CA ASN A 210 20.717 10.936 -8.164 1.00 78.95 C

ATOM 3206 CB ASN A 210 20.251 12.335 -8.576 1.00 83.73 C

ATOM 3209 CG ASN A 210 21.408 13.355 -8.850 1.00 85.95 C

ATOM 3210 ODl ASN A 210 22.542 13.249 -8.323 1.00 81.95 O

ATOM 3211 ND2 ASN A 210 21.065 14.416 -9.643 1.00 92.19 N

ATOM 3214 C ASN A 210 21.360 10.886 -6.758 1.00 75.18 C

ATOM 3215 O ASN A 210 22.583 10.777 -6.639 1.00 72.10 O

ATOM 3216 N GLN A 211 20.516 10.873 -5.716 1.00 75.07 N

ATOM 3218 CA GLN A 211 20.930 10.869 -4.335 1.00 71.75 C

ATOM 3220 CB GLN A 211 19.728 11.029 -3.403 1.00 73.99 C

ATOM 3223 CG GLN A 211 18.918 12.325 -3.575 1.00 77.34 C

ATOM 3226 CD GLN A 211 19.620 13.572 -3.094 1.00 73.73 C

ATOM 3227 OEl GLN A 211 20.318 13.552 -2.113 1.00 70.44 O

ATOM 3228 NE2 GLN A 211 19.431 14.657 -3.802 1.00 77.44 N ATOM 3231 C GLN A 211 21.690 9.671 -3.809 1.00 68.89 C

ATOM 3232 O GLN A 211 22.103 9.730 2.654 1.00 68.37 O

ATOM 3233 N CYS A 212 21.895 8.585 4.561 1.00 68.32 N

ATOM 3235 CA CYS A 212 22.445 7.341 -3.952 1.00 65.45 C

ATOM 3237 CB CYS A 212 21.877 6.071 4.588 1.00 66.69 C

ATOM 3240 SG CYS A 212 20.095 5.933 4.285 1.00 74.19 S

ATOM 3241 C CYS A 212 23.942 7.262 3.984 1.00 61.86 C

ATOM 3242 O CYS A 212 24.613 7.907 -4.833 1.00 61.22 O

ATOM 3243 N ALA A 213 24.468 6.458 -3.056 1.00 59.19 N

ATOM 3245 CA ALA A 213 25.877 6.519 -2.765 1.00 56.34 C

ATOM 3247 CB ALA A 213 26.105 6.720 -1 392 1.00 55.01 C

ATOM 3251 C ALA A 213 26.611 5.295 3.245 1.00 54.74 C

ATOM 3252 O ALA A 213 27.718 5.456 3.821 1.00 54.91 O

ATOM 3253 N ALA A 214 26.052 4.111 3.043 1.00 54.09 N

ATOM 3255 CA ALA A 214 26.786 2.893 -3 436 1.00 52.51 C

ATOM 3257 CB ALA A 214 26.982 2.055 -2 300 1.00 50.79 C

ATOM 3261 C ALA A 214 26.086 2.088 -4.486 1.00 55.33 C

ATOM 3262 O ALA A 214 26.726 1.278 .148 1.00 55.72 O

ATOM 3263 N GLY A 215 24.783 2.329 .653 1.00 58.27 N

ATOM 3265 CA GLY A 215 23.914 1.484 .445 1.00 60.72 C

ATOM 3268 C GLY A 215 22.512 1.447 .858 00 63.18 C

ATOM 3269 O GLY A 215 22.195 2.220 .951 00 62.63 O

ATOM 3270 N CYS A 216 21.657 0.574 .394 00 65.69 N

ATOM 3272 CA CYS A 216 20.258 0.586 .964 00 69.24 C

ATOM 3274 CB CYS A 216 19.535 1.716 .650 00 72.29 C

ATOM 3277 SG CYS A 216 19.657 1.623 7.430 00 74.13 S

ATOM 3278 C CYS A 216 19.447 -0.665 5.227 00 71.77 C

ATOM 3279 O CYS A 216 19.886 -1.583 5.916 00 71.93 O

ATOM 3280 N THR A 217 18.233 -0.626 4.696 00 73.98 N

ATOM 3282 CA THR A 217 17.304 -1.724 4.665 00 76.58 C

ATOM 3284 CB THR A 217 16.933 -1.861 3.231 00 76.60 C

ATOM 3286 OGl THR A 217 18.073 -2.376 2.558 00 71.61 O

ATOM 3288 CG2 THR A 217 15.797 -2.863 -2 987 00 81.96 C

ATOM 3292 C THR A 217 16.089 -1.360 5.465 00 81.10 C

ATOM 3293 O THR A 217 15.039 -1.958 5.310 00 84.07 O

ATOM 3294 N GLY A 218 16.232 -0.341 6.305 00 81.30 N

ATOM 3296 CA GLY A 218 15.083 0.262 6.937 00 86.06 C

ATOM 3299 C GLY A 218 15.298 1.697 7.356 00 85.69 C

ATOM 3300 O GLY A 218 16.323 2.320 7.062 00 81.26 O

ATOM 3301 N PRO A 219 14.270 2.229 8.003 1.00 90.50 N

ATOM 3302 CA PRO A 219 14.353 .496 8.749 1.00 91.95 C

ATOM 3304 CB PRO A 219 12.956 .600 9.384 1.00 98.27 C

ATOM 3307 CG PRO A 219 12.042 .762 8.489 1.00 99.76 C

ATOM 3310 CD PRO A 219 12.909 656 8.018 1.00 95.47 C

ATOM 3313 C PRO A 219 14.624 4.769 7.946 1.00 90.33 C

ATOM 3314 O PRO A 219 15.405 5.591 8.349 00 88.23 O

ATOM 3315 N ARG A 220 13.981 4.904 6.810 00 91.91 N

ATOM 3317 CA ARG A 220 13.738 6.217 6.233 1.00 93.99 C

ATOM 3319 CB ARG A 220 12.218 6.360 904 1.00100.22 C

ATOM 3322 CG ARG A 220 11.634 5.167 100 1.00102.19 C

ATOM 3325 CD ARG A 220 10.103 5.144 836 1.00109.43 C

ATOM 3328 NE ARG A 220 9.740 3.785 386 1.00111.00 N

ATOM 3330 CZ ARG A 220 8.505 3.358 4.091 1.00115.28 C

ATOM 3331 NHl ARG A 220 7.446 4.179 - 4.177 1.00118.66 N

ATOM 3334 NH2 ARG A 220 8.347 2.087 -3 696 1.00114.53 N

ATOM 3337 C ARG A 220 14.631 6.612 5.014 1.00 89.71 C

ATOM 3338 O ARG A 220 15.450 5.829 4.543 1.00 86.23 O

ATOM 3339 N GLU A 221 14.468 7.873 4.587 1.00 90.79 N

ATOM 3341 CA GLϋ A 221 14.998 8.469 3.350 1.00 88.14 C

ATOM 3343 CB GLU A 221 14.054 9.612 2.885 1.00 92.21 C

ATOM 3346 CG GLU A 221 13.975 10.853 3.765 1.00 95.00 C

ATOM 3349 CD GLU A 221 12.697 10.962 -4 627 1.00103.69 C

ATOM 3350 OEl GLU A 221 12.320 9.931 5.267 1.00106.17 O

ATOM 3351 OE2 GLU A 221 12.071 12.079 - 4.702 1.00106.53 O

ATOM 3352 C GLU A 221 15.116 7.478 -2.181 1.00 86.16 C

ATOM 3353 O GLU A 221 16.103 7.484 -1.457 1.00 82.16 O

ATOM 3354 N SER A 222 14.086 6.661 -1.965 1.00 89.43 N

ATOM 3356 CA SER A 222 14.027 5.806 -0.769 1.00 88.57 C ATOM 3358 CB SER A 222 12.580 683 ^•0.281 .00 93.94 C

ATOM 3361 OG SER A 222 11.809 919 ^•1.194 .00 96.86 O

ATOM 3363 C SER A 222 14.640 4.395 0.949 .00 85.65 C

ATOM 3364 O SER A 222 14.676 3.619 0.016 .00 85.41 O

ATOM 3365 N ASP A 223 15.135 4.061 ^■2.150 .00 83.69 N

ATOM 3367 CA ASP A 223 15.657 2.711 ^•2.417 .00 80.96 C

ATOM 3369 CB ASP A 223 15.185 2.195 3.776 .00 83.33 C

ATOM 3372 CG ASP A 223 13.703 2.299 3.944 .00 89.14 C

ATOM 3373 ODl ASP A 223 12.981 1.875 3.024 1.00 91.08 O

ATOM 3374 OD2 ASP A 223 13.165 2.800 4.951 1.00 92.92 O

ATOM 3375 C ASP A 223 17.171 2.672 2.346 1.00 75.27 C

ATOM 3376 O ASP A 223 17.825 1.737 2.855 1.00 73.21 O

ATOM 3377 N CYS A 224 17.746 3.656 -1 683 1.00 72.71 N

ATOM 3379 CA CYS A 224 19.181 3.736 -1.655 1.00 67.99 C

ATOM 3381 CB CYS A 224 19.598 5.080 -1.135 1.00 67.67 C

ATOM 3384 SG CYS A 224 19.506 6.395 -2.344 1.00 70.46 S

ATOM 3385 C CYS A 224 19.754 2.694 -0.764 1.00 64.94 C

ATOM 3386 O CYS A 224 19.110 2.246 0.162 1 .00 65.66 O

ATOM 3387 N LEU A 225 20.979 2.321 -1.078 1.00 61.70 N

ATOM 3389 CA LEU A 225 21.782 1.447 -0.245 1.00 59.61 C

ATOM 3391 CB LEU A 225 22.986 0.868 023 1.00 56.35 C

ATOM 3394 CG LEU A 225 22.685 -0.402 891 1.00 56.31 C

ATOM 3396 CDl LEU A 225 23.880 -0.866 679 1.00 51.61 C

ATOM 3400 CD2 LEU A 225 22.126 -1.570 021 1.00 56.37 C

ATOM 3404 C LEU A 225 22.260 2.296 0.878 1.00 59.46 C

ATOM 3405 O LEU A 225 22.097 1.964 2.032 1.00 60.50 O

ATOM 3406 N VAL A 226 22.876 3.410 0.501 1.00 59.46 N

ATOM 3408 CA VAL A 226 23.450 4.366 1.417 1.00 58.35 C

ATOM 3410 CB VAL A 226 25.010 4.197 1.616 1.00 54.93 C

ATOM 3412 CGl VAL A 226 25.384 4.755 2.905 1.00 57.11 C

ATOM 3416 CG2 VAL A 226 25.449 2.804 1.665 1.00 54.18 C

ATOM 3420 C VAL A 226 23.165 5.729 0.779 1.00 59.60 C

ATOM 3421 O VAL A 226 22.958 5.810 -0.407 1.00 60.42 O

ATOM 3422 N CYS A 227 23.138 6.793 1.574 1.00 60.27 N

ATOM 3424 CA CYS A 227 22.873 8.110 1.052 1.00 62.07 C

ATOM 3426 CB CYS A 227 22.091 8.926 2.031 .00 64.54 C

ATOM 3429 SG CYS A 227 20.427 8.315 2.115 .00 71.77 S

ATOM 3430 C CYS A 227 24.164 8.781 0.891 .00 59.58 C

ATOM 3431 O CYS A 227 25.088 8.519 1.662 .00 57.51 O

ATOM 3432 N ARG A 228 24.235 9.677 -0.087 1.00 60.72 N

ATOM 3434 CA ARG A 228 25.465 10.401 -0.289 1.00 58.88 C

ATOM 3436 CB ARG A 228 25.938 10.420 -1.728 1.00 58.79 C

ATOM 3439 CG ARG A 228 25.066 10.857 -2.770 1.00 60.60 C

ATOM 3442 CD ARG A 228 25.870 11.291 -4.034 1.00 60.85 C

ATOM 3445 NE ARG A 228 25.464 12.688 -4.273 1.00 66.58 N

ATOM 3447 CZ ARG A 228 25.007 13.147 -5.391 1.00 68.99 C

ATOM 3448 NHl ARG A 228 24.950 12.391 -6.479 1.00 73.85 N

ATOM 3451 NH2 ARG A 228 24.612 14.369 -5 438 1.00 73.63 N

ATOM 3454 C ARG A 228 25.487 11.753 0.315 1.00 60.04 C

ATOM 3455 O ARG A 228 26.542 12.340 0.407 1 .00 59.64 O

ATOM 3456 N LYS A 229 24.352 12.222 0.791 1.00 62.48 N

ATOM 3458 CA LYS A 229 24.353 13.442 1.549 1.00 63.66 C

ATOM 3460 CB LYS A 229 23.648 14.573 0.792 1.00 67.05 C

ATOM 3463 CG LYS A 229 24.518 15.066 ^■0.385 1.00 67.47 C

ATOM 3466 CD LYS A 229 23.831 16.061 -1.381 1.00 73.70 C

ATOM 3469 CE LYS A 229 24.848 16.474 -2.543 1.00 75.33 C

ATOM 3472 NZ LYS A 229 24.415 17.315 -3.811 1.00 79.07 N

ATOM 3476 C LYS A 229 23.794 13.092 2.898 1.00 63.63 C

ATOM 3477 O LYS A 229 24.536 12.696 3.782 1.00 61.98 O

ATOM 3478 N PHE A 230 22.501 13.163 3.054 1.00 66.52 N

ATOM 3480 CA PHE A 230 21.906 12.856 4.332 1.00 68.08 C

ATOM 3482 CB PHE A 230 21.322 14.129 4.906 1.00 71.57 C

ATOM 3485 CG PHE A 230 22.344 15.070 5.540 1.00 72.46 C

ATOM 3486 CDl PHE A 230 22.787 16.209 4.888 1.00 74.10 C

ATOM 3488 CEl PHE A 230 23.692 17.117 5.502 1.00 74.49 C

ATOM 3490 CZ PHE A 230 24.146 16.887 6.773 1.00 74.16 C

ATOM 3492 CE2 PHE A 230 23.716 15.748 7.443 1.00 73.51 C

ATOM 3494 CD2 PHE A 230 22.800 14.859 6.831 1.00 74.05 C ATOM 3496 C PHE A 230 20.816 11.770 4.136 1.00 69.44 C

ATOM 3497 O PHE A 230 20.160 11.708 3. .069 1.00 71.17 O

ATOM 3498 N ARG A 231 20.676 10.891 5..130 1.00 68.61 N

ATOM 3500 CA ARG A 231 19.584 9.915 5.195 1.00 70.29 C

ATOM 3502 CB ARG A 231 20.074 8.526 5.708 1.00 67.41 C

ATOM 3511 C ARG A 231 18.552 10.519 6.134 1.00 74.06 C

ATOM 3512 O ARG A 231 18.922 11.069 7.149 1.00 73.47 O

ATOM 3513 N ASP A 232 17.274 10.431 5.798 1.00 78.37 N

ATOM 3515 CA ASP A 232 16.234 10.971 6.662 1.00 84.33 C

ATOM 3517 CB ASP A 232 15.144 11.728 5.891 1.00 88.64 C

ATOM 3520 CG ASP A 232 14.232 12.510 6.806 1.00 92.77 C

ATOM 3521 ODl ASP A 232 14.285 12.270 8.018 1.00 92.46 O

ATOM 3522 OD2 ASP A 232 13.441 13.392 6.417 1.00 96.60 O

ATOM 3523 C ASP A 232 15.612 9.869 7.492 1.00 87.11 C

ATOM 3524 O ASP A 232 15.962 9.695 8.668 1.00 88.04 O

ATOM 3525 N GLO A 233 14.665 9.150 6.910 1.00 89.56 N

ATOM 3527 CA GLU A 233 13.976 8.117 7.627 1.00 91.75 C

ATOM 3529 CB GLD A 233 12.599 8.613 8.111 1.00 97.99 C

ATOM 3532 CG GLU A 233 12.519 8.786 9.622 1.00100.66 C

ATOM 3535 CD GLU A 233 11.380 9.704 10.061 1.00109.45 C

ATOM 3536 OEl GLU A 233 10.502 9.995 9.208 1.00113.90 O

ATOM 3537 OE2 GLϋ A 233 11.348 10.144 11.258 1.00112.63 O

ATOM 3538 C GLU A 233 13.901 7.127 6.539 1.00 90.22 C

ATOM 3539 O GLϋ A 233 12.882 6.953 5..916 1.00 94.09 O

ATOM 3540 N ALA A 234 15.026 6.560 6..197 1.00 85.19 N

ATOM 3542 CA ALA A 234 15.025 5.743 4.982 1.00 84.82 C

ATOM 3544 CB ALA A 234 13.817 4.741 5.027 1.00 88.93 C

ATOM 3548 C ALA A 234 15.060 6.514 3.595 1.00 84.64 C

ATOM 3549 O ALA A 234 15.340 5.900 2.543 1.00 83.37 O

ATOM 3550 N THR A 235 14.790 7.827 3.601 1.00 85.96 N

ATOM 3552 CA THR A 235 14.869 8.675 402 1.00 85.56 C

ATOM 3554 CB THR A 235 13.751 9.674 489 1.00 90.41 C

ATOM 3556 OGl THR A 235 12.551 8.977 820 1.00 94.00 O

ATOM 3558 CG2 THR A 235 13.455 10.298 1.155 1.00 91.65 C

ATOM 3562 C THR A 235 16.208 9.413 2.264 1.00 81.37 C

ATOM 3563 O THR A 235 16.840 9.680 3.237 1.00 80.40 O

ATOM 3564 N CYS A 236 16.631 9.764 1.059 1.00 80.26 N

ATOM 3566 CA CYS A 236 17.911 10.456 0.845 1.00 76.60 C

ATOM 3568 CB CYS A 236 18.705 9.695 -0.191 1.00 73.69 C

ATOM 3571 SG CYS A 236 19.452 8.145 0.356 1.00 71.68 S

ATOM 3572 C CYS A 236 17.771 11.919 0.358 1.00 78.31 C

ATOM 3573 O CYS A 236 17.255 12.169 -0.717 1.00 80.49 O

ATOM 3574 N LYS A 237 18.295 12.873 1.114 1.00 77.15 N

ATOM 3576 CA LYS A 237 18.017 14.294 0.879 1.00 79.48 C

ATOM 3578 CB LYS A 237 17.178 14.842 2.038 1.00 82.43 C

ATOM 3581 CG LYS A 237 16.038 13.951 2.407 1.00 84.83 C

ATOM 3584 CD LYS A 237 15.070 14.580 3.357 1.00 90.16 C

ATOM 3587 CE LYS A 237 13.746 13.819 3.358 1.00 94.88 C

ATOM 3590 NZ LYS A 237 12.689 14.539 4.103 1.00102.61 N

ATOM 3594 C LYS A 237 19.292 15.106 0.759 1.00 76.46 C

ATOM 3595 O LYS A 237 20.312 14.741 1.276 1.00 72.36 O

ATOM 3596 N ASP A 238 19.216 16.234 0.079 1.00 78.98 N

ATOM 3598 CA ASP A 238 20.321 17.193 0.047 1.00 77.64 C

ATOM 3600 CB ASP A 238 19.975 18.348 -0.895 1.00 81.85 C

ATOM 3603 CG ASP A 238 19.772 17.891 -2.338 1.00 82.50 C

ATOM 3604 ODl ASP A 238 20.406 16.888 -2.690 1.00 80.05 O

ATOM 3605 OD2 ASP A 238 19.015 18.454 -3.170 1.00 84.38 O

ATOM 3606 C ASP A 238 20.641 17.763 1..424 1.00 76.62 C

ATOM 3607 O ASP A 238 21.770 18.114 1..707 1.00 73.74 O

ATOM 3608 N THR A 239 19.645 17.833 2..290 1.00 79.33 N

ATOM 3610 CA THR A 239 19.820 18.465 3..586 1.00 80.08 C

ATOM 3612 CB THR A 239 19.799 20.008 3.363 1.00 84.18 C

ATOM 3614 OGl THR A 239 20.373 20.685 4.484 1.00 83.41 O

ATOM 3616 CG2 THR A 239 18.371 20.544 3.222 1.00 88.96 C

ATOM 3620 C THR A 239 18.769 18.064 4.591 1.00 82.04 C

ATOM 3621 O THR A 239 17.690 17.627 4.250 1.00 84.18 O

ATOM 3622 N CYS A 240 19.076 18.261 5.847 1.00 82.76 N

ATOM 3624 CA CYS A 240 18.073 18.046 6.850 1.00 87.41 C ATOM 3626 CB CYS A 240 18.686 17.977 8.227 1.00 85.89 C

ATOM 3629 SG CYS A 240 19.820 16.589 8.264 1.00 84.87 S

ATOM 3630 C CYS A 240 17.039 19.132 6.784 1.00 93.59 C

ATOM 3631 O CYS A 240 17.356 20.313 6.683 1.00 95.73 O

ATOM 3632 N PRO A 241 15.780 18.740 6.812 1.00 55.04 N

ATOM 3633 CA PRO A 241 14.682 19.707 6.985 1.00 56.88 C

ATOM 3635 CB PRO A 241 13.431 18.836 7.235 1.00 58.19 C

ATOM 3638 CG PRO A 241 13.919 17.393 7.321 1.00 57.06 C

ATOM 3641 CD PRO A 241 15.281 17.357 6.687 1.00 54.91 C

ATOM 3644 C PRO A 241 14.936 20.540 8.198 1.00 57.83 C

ATOM 3645 O PRO A 241 15.201 20.028 9.281 1.00 57.58 O

ATOM 3646 N PRO A 242 14.852 21.827 8.038 1.00 58.40 N

ATOM 3647 CA PRO A 242 15.392 22.690 9.071 1.00 59.18 C

ATOM 3649 CB PRO A 242 15.812 23.929 8.325 1.00 59.59 C

ATOM 3652 CG PRO A 242 15.087 23.771 6.931 1.00 60.42 C

ATOM 3655 CD PRO A 242 14.198 22.555 6.961 1.00 58.64 C

ATOM 3658 C PRO A 242 14.349 22.986 10.097 1.00 60.49 C

ATOM 3659 O PRO A 242 13.169 22.609 9.956 1.00 58.83 O

ATOM 3660 N LEU A 243 14.859 23.681 11.113 1.00 61.42 N

ATOM 3662 CA LED A 243 14.198 23.925 12.387 1.00 63.21 C

ATOM 3664 CB LEU A 243 15.253 24.301 13.402 1.00 63.51 C

ATOM 3667 CG LEU A 243 16.030 23.016 13.747 1.00 64.54 C

ATOM 3669 CDl LEU A 243 17.404 23.380 14.430 1.00 64.32 C

ATOM 3673 CD2 LEU A 243 15.119 21.989 14.577 1.00 64.65 C

ATOM 3677 C LEU A 243 13.212 25.037 12.331 1.00 64.28 C

ATOM 3678 O LEU A 243 12.271 25.089 13.119 1.00 65.42 O

ATOM 3679 N MET A 244 13.425 25.919 11.372 1.00 63.70 N

ATOM 3681 CA MET A 244 12.606 27.066 11.251 1.00 65.18 C

ATOM 3683 CB MET A 244 13.312 28.151 11.980 1.00 65.81 C

ATOM 3686 CG MET A 244 13.551 27.784 13.412 1.00 66.25 C

ATOM 3689 SD MET A 244 13.078 29.142 14.347 1.00 72.32 S

ATOM 3690 CE MET A 244 11.731 28.403 15.295 1.00 73.17 C

ATOM 3694 C MET A 244 12.399 27.474 9.833 1.00 65.08 C

ATOM 3695 O MET A 244 13.312 27.447 9.054 1.00 63.58 O

ATOM 3696 N LEU A 245 11.177 27.876 9.529 1.00 67.08 N

ATOM 3698 CA LEU A 245 10.803 28.355 8.241 1.00 67.76 C

ATOM 3700 CB LEU A 245 9.739 27.435 7.703 1.00 68.55 C

ATOM 3703 CG LEU A 245 10.253 26.021 7.432 1.00 67.01 C

ATOM 3705 CDl LEU A 245 9.067 25.110 7.212 1.00 68.07 C

ATOM 3709 CD2 LEU A 245 11.186 25.963 6.238 1.00 65.23 C

ATOM 3713 C LEU A 245 10.185 29.719 8.344 1.00 70.42 C

ATOM 3714 O LEU A 245 9.435 29.957 9.281 1.00 71.97 O

ATOM 3715 N TYR A 246 10.457 30.590 7.355 1.00 70.54 N

ATOM 3717 CA TYR A 246 9.619 31.746 7.100 1.00 72.93 C

ATOM 3719 CB TYR A 246 10.028 32.498 5.833 1.00 72.99 C

ATOM 3722 CG TYR A 246 9.424 33.903 5.785 1.00 76.04 C

ATOM 3723 CDl TYR A 246 10.123 34.980 6.284 1.00 76.12 C

ATOM 3725 CEl TYR A 246 9.595 36.220 6.294 1.00 78.89 C

ATOM 3727 CZ TYR A 246 8.358 36.417 5.810 1.00 80.72 C

ATOM 3728 OH TYR A 246 7.871 37.715 5.849 1.00 84.16 O

ATOM 3730 CE2 TYR A 246 7.616 35.344 5.325 1.00 79.96 C

ATOM 3732 CD2 TYR A 246 8.134 34.126 5.310 1.00 76.25 C

ATOM 3734 C TYR A 246 8.167 31.318 6.950 1.00 75.65 C

ATOM 3735 O TYR A 246 7..842 30.513 6.113 1.00 75.18 O

ATOM 3736 N ASN A 247 7.289 31.893 7.749 1.00 79.06 N

ATOM 3738 CA ASN A 247 5..865 31.606 7.710 1.00 81.97 C

ATOM 3740 CB ASN A 247 5.369 31.485 9.144 1.00 83.33 C

ATOM 3743 CG ASN A 247 4.117 30.711 9.248 1.00 86.35 C

ATOM 3744 ODl ASN A 247 3.048 31.184 8.805 1.00 90.91 O

ATOM 3745 ND2 ASN A 247 4.212 29.494 9.824 1.00 83.97 N

ATOM 3748 C ASN A 247 5.152 32.746 7.008 1.00 84.93 C

ATOM 3749 O ASN A 247 5.206 33.878 7.458 1.00 85.90 O

ATOM 3750 N PRO A 248 4.500 32.451 5.903 1.00 86.39 N

ATOM 3751 CA PRO A 248 3.782 33.478 5.096 1.00 90.09 C

ATOM 3753 CB PRO A 248 3.144 32.675 3.968 1.00 90.03 C

ATOM 3756 CG PRO A 248 3.918 31.316 3.957 1.00 86.36 C

ATOM 3759 CD PRO A 248 4.423 31.092 5.346 1.00 84.43 C

ATOM 3762 C PRO A 248 2.673 34.251 5.837 1.00 94.90 C ATOM 3763 O PRO A 248 2.511 35.494 5. 1.00 96.88 O

ATOM 3764 N THR A 249 1.905 33.491 6.619 1.00 96.37 N

ATOM 3766 CA THR A 249 0.842 34.054 7.446 1.00101.00 C

ATOM 3768 CB THR A 249 -0.184 32.930 7.919 1.00102.23 C

ATOM 3770 OGl THR A 249 -1.321 32.895 7.044 1.00104.68 O

ATOM 3772 CG2 THR A 249 -0.848 33.250 9.282 1.00105.46 C

ATOM 3776 C THR A 249 1.457 34.842 8.633 1.00100.86 C

ATOM 3777 O THR A 249 1.021 35.972 8.921 1.00104.58 O

ATOM 3778 N THR A 250 2.463 34.262 9.304 1.00 96.81 N

ATOM 3780 CA THR A 250 3.064 34.893 10.490 1.00 95.38 C

ATOM 3782 CB THR A 250 3.973 33.896 11.305 1. 00 91.35 C

ATOM 3784 OGl THR A 250 3.395 32.584 11.401 1.00 90.19 O

ATOM 3786 CG2 THR A 250 4.032 34.315 12.723 1.00 91.91 C

ATOM 3790 C THR A 250 3..893 36.124 10.108 1.00 94.90 C

ATOM 3791 O THR A 250 4..075 37.028 10.936 1.00 96.04 O

ATOM 3792 N TYR A 251 4..380 36.156 8.861 1.00 93.34 N

ATOM 3794 CA TYR A 251 5.414 37.103 8.412 1.00 92.01 C

ATOM 3796 CB TYR A 251 4.905 38.559 8.423 1.00 95.71 C

ATOM 3799 CG TYR A 251 3.736 38.867 7.485 1.00100.54 C

ATOM 3800 CDl TYR A 251 2.415 38.810 7.927 1.00103.41 C

ATOM 3802 CEl TYR A 251 1.387 39.090 7.079 1.00106.88 C

ATOM 3804 CZ TYR A 251 1.655 39.462 5.781 1.00106.57 C

ATOM 3805 OH TYR A 251 0.633 39.762 4.918 1.00110.34 O

ATOM 3807 CE2 TYR A 251 2.937 39.552 5.333 1.00102.86 C

ATOM 3809 CD2 TYR A 251 3.962 39.262 6.165 1.00100.61 C

ATOM 3811 C TYR A 251 6.699 36.995 9.259 1.00 88.23 C

ATOM 3812 O TYR A 251 7.362 37.985 9.536 1.00 88.44 O

ATOM 3813 N GLN A 252 7.059 35.806 9.697 1.00 84.91 N

ATOM 3815 CA GLN A 252 8.325 35.701 10.397 1.00 81.92 C

ATOM 3817 CB GLN A 252 8.134 36.158 11.840 1.00 82.92 C

ATOM 3820 CG GLN A 252 7.289 35.204 12.679 1.00 84.45 C

ATOM 3823 CD GLN A 252 6.830 35.822 13.980 1.00 88.01 C

ATOM 3824 OEl GLN A 252 7.570 36.606 14.587 1.00 89.53 O

ATOM 3825 NE2 GLN A 252 5.603 35.504 14.406 1.00 89.99 N

ATOM 3828 C GLN A 252 8.961 34.304 10.327 1.00 78.33 C

ATOM 3829 O GLN A 252 8.474 33.408 9.676 1.00 76.85 O

ATOM 3830 N MET A 253 10.095 34.153 10.987 1.00 76.53 N

ATOM 3832 CA MET A 253 10.666 32.843 11.258 1.00 74.03 C

ATOM 3834 CB MET A 253 12.137 32.999 11.601 1.00 71.87 C

ATOM 3837 CG MET A 253 12.931 33.489 10.435 1.00 71.14 C

ATOM 3840 SD MET A 253 12.878 32.239 9.059 1.00 75.45 S

ATOM 3841 CE MET A 253 12.407 33.204 7.938 1.00 75.10 C

ATOM 3845 C MET A 253 9.874 32.178 12.387 1.00 75.06 C

ATOM 3846 O MET A 253 9.697 32.729 13.464 1.00 76.02 O

ATOM 3847 N ASP A 254 9.369 30.994 12.098 1.00 75.32 N

ATOM 3849 CA ASP A 254 8.560 30.212 13.023 1.00 76.65 C

ATOM 3851 CB ASP A 254 7.086 30.304 12.587 1.00 79.52 C

ATOM 3854 CG ASP A 254 6.174 30.884 13.663 1.00 82.89 C

ATOM 3855 ODl ASP A 254 6.563 30.843 14.866 1.00 82.32 O

ATOM 3856 OD2 ASP A 254 5.037 31.370 13.376 1.00 86.13 O

ATOM 3857 C ASP A 254 9.022 28.724 13.021 1.00 74.63 C

ATOM 3858 O ASP A 254 9.382 28.192 11.985 1.00 73.66 O

ATOM 3859 N VAL A 255 8.988 28.059 14.174 1.00 74.49 N

ATOM 3861 CA VAL A 255 9.301 26.612 14.277 1.00 72.81 C

ATOM 3863 CB VAL A 255 8.787 25.976 15.627 1.00 73.73 C

ATOM 3865 CGl VAL A 255 9.722 24.890 16.070 1.00 72.16 C

ATOM 3869 CG2 VAL A 255 8.622 27.020 16.785 1.00 76.62 C

ATOM 3873 C VAL A 255 8.707 25.762 13.148 1.00 72.23 C

ATOM 3874 O VAL A 255 7.497 25.708 12.977 1.00 73.53 O

ATOM 3875 N ASN A 256 9.566 25.088 12.389 1.00 70.27 N

ATOM 3877 CA ASN A 256 9.101 24.122 11.380 1.00 70.31 C

ATOM 3879 CB ASN A 256 10.182 23.791 10.348 1.00 67.62 C

ATOM 3882 CG ASN A 256 9.858 22.537 9.502 1.00 65.90 C

ATOM 3883 ODl ASN A 256 8.855 21.859 9.709 1.00 65.23 O

ATOM 3884 ND2 ASN A 256 10.740 22.225 8.558 1.00 63.09 N

ATOM 3887 C ASN A 256 8.719 22.844 12.077 1.00 71.03 C

ATOM 3888 O ASN A 256 9.570 22.241 12.710 1.00 68.99 O

ATOM 3889 N PRO A 257 7.457 22.424 11.954 1.00 74.05 N ATOM 3890 CA PRO A 257 7.007 21.212 12.660 1.00 74.85 C

ATOM 3892 CB PRO A 257 5.467 21.181 12.420 1.00 77.52 C

ATOM 3895 CG PRO A 257 5.247 21.916 11.101 1.00 78.04 C

ATOM 3898 CD PRO A 257 6.380 23.014 11.114 1.00 76.18 C

ATOM 3901 C PRO A 257 7.711 19.971 12.080 1.00 72.67 C

ATOM 3902 O PRO A 257 8.226 19.202 12.894 1.00 73.12 O

ATOM 3903 N GLU A 258 7.762 19.793 10.752 1.00 71.09 N

ATOM 3905 CA GLU A 258 8.441 18.626 10.148 1.00 68.98 C

ATOM 3907 CB GLU A 258 8.100 18.532 8.631 1.00 68.15 C

ATOM 3914 C GLU A 258 9.997 18.534 10.399 1.00 66.74 C

ATOM 3915 O GLU A 258 10.638 17.563 9.979 1.00 65.05 O

ATOM 3916 N GLY A 259 10.584 19.518 11.105 1.00 66.61 N

ATOM 3918 CA GLY A 259 12.031 19.749 11.122 1.00 64.31 C

ATOM 3921 C GLY A 259 12.826 18.787 11.970 1.00 63.46 C

ATOM 3922 O GLY A 259 12.237 18.134 12.863 1.00 64.80 O

ATOM 3923 N LYS A 260 14.148 18.732 11.713 1.00 61.22 N

ATOM 3925 CA LYS A 260 15.061 17.684 12.239 1.00 59.87 C

ATOM 3927 CB LYS A 260 15.012 16.435 11.361 1.00 58.96 C

ATOM 3930 CG LYS A 260 13.635 15.850 11.292 1.00 61.80 C

ATOM 3933 CD LYS A 260 13.592 14.414 10.821 1.00 63.51 C

ATOM 3936 CE LYS A 260 12.464 14.188 9.801 1.00 64.20 C

ATOM 3939 NZ LYS A 260 11.982 12.820 9.961 1.00 68.50 N

ATOM 3943 C LYS A 260 16.528 18.103 12.418 1.00 57.61 C

ATOM 3944 O LYS A 260 17.017 18.961 11.792 1.00 57.42 O

ATOM 3945 N TYR A 261 17.211 17.436 13.305 1.00 56.94 N

ATOM 3947 CA TYR A 261 18.543 17.762 13.716 1.00 55.87 C

ATOM 3949 CB TYR A 261 18.663 17.429 15.213 1.00 56.86 C

ATOM 3952 CG TYR A 261 17.714 18.203 16.097 1.00 58.81 C

ATOM 3953 CDl TYR A 261 16.747 17.586 16.878 1.00 62.63 C

ATOM 3955 CEl TYR A 261 15.864 18.338 17.722 1.00 63.21 C

ATOM 3957 CZ TYR A 261 15.972 19.694 17.733 1.00 64.10 C

ATOM 3958 OH TYR A 261 15.188 20.526 18.498 1.00 67.69 O

ATOM 3960 CE2 TYR A 261 16.924 20.311 16.958 1.00 64.45 C

ATOM 3962 CD2 TYR A 261 17.785 19.570 16.154 1.00 61.93 C

ATOM 3964 C TYR A 261 19.496 16.898 12.904 1.00 54.12 C

ATOM 3965 O TYR A 261 19.153 15.858 12.422 1.00 53.80 O

ATOM 3966 N SER A 262 20.729 17.298 12.811 1.00 53.84 N

ATOM 3968 CA SER A 262 21.669 16.598 12.024 1.00 53.32 C

ATOM 3970 CB SER A 262 22.452 17.594 11.178 1.00 52.59 C

ATOM 3973 OG SER A 262 23.776 17.761 11.661 1.00 53.41 O

ATOM 3975 C SER A 262 22.566 15.727 12.939 1.00 54.56 C

ATOM 3976 O SER A 262 23.248 16.220 13.815 1.00 55.50 O

ATOM 3977 N PHE A 263 22.561 14.423 12.719 1.00 55.44 N

ATOM 3979 CA PHE A 263 23.483 13.544 13.407 1.00 58.17 C

ATOM 3981 CB PHE A 263 22.733 12.590 14.327 1.00 59.86 C

ATOM 3984 CG PHE A 263 23.613 11.673 15.142 1.00 61.87 C

ATOM 3985 CDl PHE A 263 24.705 12.159 15.826 1.00 62.54 C

ATOM 3987 CEl PHE A 263 25.441 11.352 16.570 1.00 64.60 C

ATOM 3989 CZ PHE A 263 25.119 10.015 16.657 1.00 67.48 C

ATOM 3991 CE2 PHE A 263 24.039 9.515 16.003 1.00 65.99 C

ATOM 3993 CD2 PHE A 263 23.287 10.334 15.264 1.00 63.61 C

ATOM 3995 C PHE A 263 24.214 12.764 12.367 1.00 58.42 C

ATOM 3996 O PHE A 263 23.644 11.903 11.736 1.00 57.38 O

ATOM 3997 N GLY A 264 25.513 13.051 12.319 1.00 60.11 N

ATOM 3999 CA GLY A 264 26.439 12.853 11.228 1.00 59.81 C

ATOM 4002 C GLY A 264 25.990 12.114 10.022 1.00 58.59 C

ATOM 4003 O GLY A 264 26.208 10.919 9.926 1.00 61.26 O

ATOM 4004 N ALA A 265 25.426 12.803 9.068 1.00 56.84 N

ATOM 4006 CA ALA A 265 24.939 12.139 7.818 1.00 55.65 C

ATOM 4008 CB ALA A 265 25.948 11.151 7.134 1.00 55.54 C

ATOM 4012 C ALA A 265 23.642 11.468 8.026 1.00 54.37 C

ATOM 4013 O ALA A 265 23.287 10.620 7.246 1.00 54.14 O

ATOM 4014 N THR A 266 22.924 11.936 9.029 1.00 54.84 N

ATOM 4016 CA THR A 266 21.622 11.451 9.350 1.00 54.78 C

ATOM 4018 CB THR A 266 21.814 10.371 10.300 1.00 56.35 C

ATOM 4020 OGl THR A 266 21.628 9.203 9.556 1.00 55.31 O

ATOM 4022 CG2 THR A 266 20.782 10.293 11.424 1.00 58.51 C

ATOM 4026 C THR A 266 20.750 12.549 9.891 1.00 55.45 C ATOM 4027 O THR A 266 21.247 13.566 10.359 1.00 55.61 O

ATOM 4028 N CYS A 267 19.445 12.342 9.755 1.00 55.64 N

ATOM 4030 CA CYS A 267 18.432 13.347 10.049 1.00 56.01 C

ATOM 4032 CB CYS A 267 17.598 13.692 8.831 1.00 54.41 C

ATOM 4035 SG CYS A 267 18.513 14.786 7.754 1.00 52.64 S

ATOM 4036 C CYS A 267 17.547 12.698 11.016 1.00 57.94 C

ATOM 4037 O CYS A 267 17.059 11.627 10.716 1.00 58.45 O

ATOM 4038 N VAL A 268 17.273 13.378 12.130 1.00 59.39 N

ATOM 4040 CA VAL A 268 16.860 12.719 13.344 1.00 61.02 C

ATOM 4042 CB VAL A 268 18.164 12.290 14.042 1.00 61.46 C

ATOM 4044 CGl VAL A 268 18.230 12.613 15.536 1.00 61.61 C

ATOM 4048 CG2 VAL A 268 18.399 10.822 13.748 1.00 62.00 C

ATOM 4052 C VAL A 268 16.000 13.647 14.197 1.00 62.66 C

ATOM 4053 O VAL A 268 16.450 14.752 14.458 1.00 62.80 O

ATOM 4054 N LYS A 269 14.799 13.212 14.646 1.00 63.83 N

ATOM 4056 CA LYS A 269 13.909 14.122 15.410 1.00 65.02 C

ATOM 4058 CB LYS A 269 12.413 13.700 15.399 1.00 65.91 C

ATOM 4065 C LYS A 269 14.398 14.338 16.842 1.00 65.84 C

ATOM 4066 O LYS A 269 14.126 15.373 17.438 1.00 65.90 O

ATOM 4067 N LYS A 270 15.099 13.359 17.404 1.00 66.46 N

ATOM 4069 CA LYS A 270 15.659 13.544 18.749 1.00 67.95 C

ATOM 4071 CB LYS A 270 14.794 12.868 19.835 1.00 68.78 C

ATOM 4078 C LYS A 270 17.118 13.048 18.735 1.00 67.52 C

ATOM 4079 O LYS A 270 17.418 12.037 18.093 1.00 67.82 O

ATOM 4080 N CYS A 271 18.029 13.792 19.378 1.00 67.18 N

ATOM 4082 CA CYS A 271 19.404 13.329 19.533 1.00 67.14 C

ATOM 4084 CB CYS A 271 20.298 14.392 20.163 1.00 67.37 C

ATOM 4087 SG CYS A 271 20.613 15.867 19.148 1.00 64.80 S

ATOM 4088 C CYS A 271 19.474 12.059 20.385 1.00 69.08 C

ATOM 4089 O CYS A 271 18.591 11.760 21.157 1.00 69.41 O

ATOM 4090 N PRO A 272 20.500 11.265 20.163 1.00 70.38 N

ATOM 4091 CA PRO A 272 20.849 10.151 21.051 1.00 72.24 C

ATOM 4093 CB PRO A 272 22.117 9.577 20.427 1.00 72.83 C

ATOM 4096 CG PRO A 272 22.339 10.261 19.105 1.00 71.30 C

ATOM 4099 CD PRO A 272 21.334 11.334 18.950 1.00 69.52 C

ATOM 4102 C PRO A 272 21.148 10.500 22.518 1.00 74.35 C

ATOM 4103 O PRO A 272 21.335 11.680 22.899 1.00 72.50 O

ATOM 4104 N ALA A 273 21.207 9.460 23.360 1.00 76.92 N

ATOM 4106 CA ALA A 273 21.336 9.770 24.770 1.00 79.31 C

ATOM 4108 CB ALA A 273 21.267 8.471 25.704 1.00 81.70 C

ATOM 4112 C ALA A 273 22.660 10.549 24.920 1.00 80.08 C

ATOM 4113 O ALA A 273 23.657 10.214 24.269 1.00 81.25 O

ATOM 4114 N ALA A 274 22.643 11.606 25.731 1.00 80.37 N

ATOM 4116 CA ALA A 274 23.873 12.309 26.180 1.00 80.79 C

ATOM 4118 CB ALA A 274 24.953 11.284 26.709 1.00 82.92 C

ATOM 4122 C ALA A 274 24.467 13.290 25.124 1.00 79.12 C

ATOM 4123 O ALA A 274 25.525 13.931 25.359 1.00 80.24 O

ATOM 4124 N TYR A 275 23.770 13.426 23.984 1.00 76.37 N

ATOM 4126 CA TYR A 275 24.059 14.488 23.006 1.00 73.46 C

ATOM 4128 CB TYR A 275 23.851 13.945 21.589 1.00 72.66 C

ATOM 4131 CG TYR A 275 24.943 13.029 21.067 1.00 73.61 C

ATOM 4132 CDl TYR A 275 24.814 11.666 21.160 1.00 75.81 C

ATOM 4134 CEl TYR A 275 25.821 10.768 20.623 1.00 78.82 C

ATOM 4136 CZ TYR A 275 26.949 11.265 19.972 1.00 77.14 C

ATOM 4137 OH TYR A 275 27.922 10.378 19.496 1.00 74.15 O

ATOM 4139 CE2 TYR A 275 27.068 12.649 19.842 1.00 76.49 C

ATOM 4141 CD2 TYR A 275 26.066 13.529 20.396 1.00 74.32 C

ATOM 4143 C TYR A 275 23.253 15.819 23.224 1.00 70.60 C

ATOM 4144 O TYR A 275 22.179 15.869 23.817 1.00 69.08 O

ATOM 4145 N VAL A 276 23.819 16.887 22.710 1.00 68.49 N

ATOM 4147 CA VAL A 276 23.309 18.203 22.896 1.00 66.88 C

ATOM 4149 CB VAL A 276 24.361 19.009 23.644 1.00 67.40 C

ATOM 4151 CGl VAL A 276 24.077 20.468 23.538 1.00 66.99 C

ATOM 4155 CG2 VAL A 276 24.424 18.581 25.105 1.00 69.12 C

ATOM 4159 C VAL A 276 23.119 18.799 21.516 1.00 65.33 C

ATOM 4160 O VAL A 276 23.945 18.554 20.648 1.00 64.97 O

ATOM 4161 N VAL A 277 22.077 19.608 21.316 1.00 64.18 N

ATOM 4163 CA VAL A 277 21.895 20.312 20.051 1.00 63.43 C ATOM 4165 CB VAL A 277 20.423 20.537 19.793 00 63.64 C

ATOM 4167 CGl VAL A 277 20.178 21.579 18.660 00 63.81 C

ATOM 4171 CG2 VAL A 277 19.719 19.232 19.503 00 63.12 C

ATOM 4175 C VAL A 277 22.591 21.672 20.042 00 63.46 C

ATOM 4176 O VAL A 277 22.630 22.344 20.998 00 64.27 O

ATOM 4177 N THR A 278 23.107 22.065 18.912 00 64.13 N

ATOM 4179 CA THR A 278 23.883 23.273 18.716 00 65.38 C

ATOM 4181 CB THR A 278 24.924 22.973 17.652 1.00 65.09 C

ATOM 4183 OGl THR A 278 25.926 22.130 18.219 1.00 66.18 O

ATOM 4185 CG2 THR A 278 25.683 24.189 17.208 1.00 67.03 C

ATOM 4189 C THR A 278 22.963 24.272 18.124 1.00 66.33 C

ATOM 4190 O THR A 278 21.894 23.912 17.678 1.00 66.13 O

ATOM 4191 N ASP A 279 23.387 25.530 18.075 1..0 000 68.38 N

ATOM 4193 CA ASP A 279 22.622 26.565 17.371 .0 000 69.35 C

ATOM 4195 CB ASP A 279 23.231 27.974 17.663 1..0 000 70.17 C

ATOM 4198 CG ASP A 279 22.622 28.619 18.927 1..0 000 74.12 C

ATOM 4199 ODl ASP A 279 21.509 28.147 19.255 1..0 000 80.61 O

ATOM 4200 OD2 ASP A 279 23.129 29.541 19.668 1..0 000 75.22 O

ATOM 4201 C ASP A 279 22.387 26.333 15.837 1. 00 68.57 C

ATOM 4202 O ASP A 279 21.493 26.966 15.271 1. 00 69.77 O

ATOM 4203 N HIS A 280 23.158 25.484 15.155 1. 00 67.36 N

ATOM 4205 CA HIS A 280 22.837 25.161 13.757 1. 00 66.40 C

ATOM 4207 CB HIS A 280 24.111 24.930 12.934 1. 00 67.43 C

ATOM 4210 CG HIS A 280 25.044 26.101 12.966 1 1. 00 75.84 C

ATOM 4211 NDl HIS A 280 24.803 27.271 12.246 1 1. 00 83.72 N

ATOM 4213 CEl HIS A 280 25.755 28.167 12.529 1 1. 00 86.54 C

ATOM 4215 NE2 HIS A 280 26.613 27.618 13.393 1 1. 00 86.77 N

ATOM 4217 CD2 HIS A 280 26.187 26.325 13.689 1.00 82.80 C

ATOM 4219 C HIS A 280 21.928 23.935 13.660 1 .00 63.82 C

ATOM 4220 O HIS A 280 21.670 23.449 12.583 1.00 62.82 O

ATOM 4221 N GLY A 281 21.454 23.433 14.786 1.00 62.07 N

ATOM 4223 CA GLY A 281 20.711 22.192 14.803 1.00 60.37 C

ATOM 4226 C GLY A 281 21.450 20.874 14.599 00 58.17 C

ATOM 4227 O GLY A 281 20.872 19.957 14.053 00 54.70 O

ATOM 4228 N SER A 282 22.674 20.769 15.099 00 58.36 N

ATOM 4230 CA SER A 282 23.451 19.518 14.988 00 59.80 C

ATOM 4232 CB SER A 282 24.823 19.766 14.377 00 59.16 C

ATOM 4235 OG SER A 282 25.214 21.051 14.795 1.00 62.95 O

ATOM 4237 C SER A 282 23.673 18.870 16.322 00 60.81 C

ATOM 4238 O SER A 282 23.983 19.548 17.275 00 61.77 O

ATOM 4239 N CYS A 283 23.563 17.547 16.351 1.00 61.19 N

ATOM 4241 CA CYS A 283 23.886 16.751 17.517 00 62.86 C

ATOM 4243 CB CYS A 283 23.288 15.378 17.378 00 62.70 C

ATOM 4246 SG CYS A 283 21.524 15.593 17.275 1.00 63.42 S

ATOM 4247 C CYS A 283 25.378 16.643 17.738 1.00 64.27 C

ATOM 4248 O CYS A 283 26.086 15.979 17.042 1.00 64.51 O

ATOM 4249 N VAL A 284 25.827 17.322 18.756 1.00 65.87 N

ATOM 4251 CA VAL A 284 27.194 17.333 19.161 1.00 67.25 C

ATOM 4253 CB VAL A 284 27.645 18.783 19.075 1.00 66.98 C

ATOM 4255 CGl VAL A 284 28.287 19.308 20.427 1.00 69.20 C

ATOM 4259 CG2 VAL A 284 28.515 18.989 17.847 1.00 65.40 C

ATOM 4263 C VAL A 284 27.288 16.742 20.591 1 00 69.52 C

ATOM 4264 O VAL A 284 26.303 16.509 21.280 1 ,00 68.60 O

ATOM 4265 N ARG A 285 28.494 16.492 21.043 1.00 72.61 N

ATOM 4267 CA ARG A 285 28.679 15.718 22.271 1.00 75.24 C

ATOM 4269 CB ARG A 285 30.043 15.046 22.222 1.00 77.38 C

ATOM 4272 CG ARG A 285 30.241 14.309 20.879 1.00 77.58 C

ATOM 4275 CD ARG A 285 31.506 13.520 20.741 1.00 79.64 C

ATOM 4278 NE ARG A 285 31.750 12.663 21.889 1.00 81.81 N

ATOM 4280 CZ ARG A 285 32.836 11.910 21.998 1.00 88.43 C

ATOM 4281 NHl ARG A 285 33.742 11.916 21.013 1.00 89.46 N

ATOM 4284 NH2 ARG A 285 33.035 11.135 23.078 1.00 92.89 N

ATOM 4287 C ARG A 285 28.524 16.617 23.501 1.00 75.88 C

ATOM 4288 O ARG A 285 27.908 16.216 24.524 1.00 76.68 O

ATOM 4289 N ALA A 286 29.080 17.833 23.386 1.00 75.41 N

ATOM 4291 CA ALA A 286 29.095 18.805 24.477 1.00 74.95 C

ATOM 4293 CB ALA A 286 30.314 18.614 25.312 1.00 77.22 C

ATOM 4297 C ALA A 286 29.079 20.218 23.942 1.00 73.45 C ATOM 4298 O ALA A 286 29.676 20.530 22.894 1.00 72.96 O

ATOM 4299 N CYS A 287 28.406 21.073 24.681 1.00 72.05 N

ATOM 4301 CA CYS A 287 28.399 22.468 24.351 1.00 71.75 C

ATOM 4303 CB CYS A 287 27.642 23.229 25.427 1.00 71.31 C

ATOM 4306 SG CYS A 287 25.875 22.940 25.188 1.00 73.43 S

ATOM 4307 C CYS A 287 29.768 23.066 24.284 1.00 72.75 C

ATOM 4308 O CYS A 287 30.617 22.701 25.063 1.00 73.85 O

ATOM 4309 N GLY A 288 29.938 24.051 23.398 1 1..0000 7 722..69 N

ATOM 4311 CA GLY A 288 31.088 24.947 23.428 1 1..0000 7 744..02 C

ATOM 4314 C GLY A 288 31.303 25.704 24.750 1 1..0000 7 755..81 C

ATOM 4315 O GLY A 288 30.500 25.659 25.739 1.00 76.26 O

ATOM 4316 N ALA A 289 32.440 26.388 24.813 1.00 77.00 N

ATOM 4318 CA ALA A 289 32.570 27.523 25.728 1.00 76.07 C

ATOM 4320 CB ALA A 289 34.065 27.885 25.926 1.00 78.28 C

ATOM 4324 C ALA A 289 31.802 28.638 25.003 1.00 73.43 C

ATOM 4325 O ALA A 289 31.441 28.499 23.823 1.00 72.51 O

ATOM 4326 N GLU A 290 31.556 29.741 25.680 1.00 71.93 N

ATOM 4328 CA GLU A 290 30.674 30.784 25.138 1.00 69.93 C

ATOM 4330 CB GLU A 290 30.933 31.060 23.638 1.00 69.55 C

ATOM 4337 C GLU A 290 29.204 30.388 25.378 1.00 68.43 C

ATOM 4338 O GLU A 290 28.304 31.263 25.434 1.00 66.42 O

ATOM 4339 N SER A 291 28.965 29.076 25.564 1.00 68.05 N

ATOM 4341 CA SER A 291 27.586 28.561 25.670 1.00 66.93 C

ATOM 4343 CB SER A 291 27.133 27.982 24.310 1.00 66.63 C

ATOM 4346 OG SER A 291 27.904 26.832 23.974 1.00 70.01 O

ATOM 4348 C SER A 291 27.418 27.540 26.790 1.00 65.49 C

ATOM 4349 O SER A 291 28.386 27.171 27.433 1.00 65.82 O

ATOM 4350 N TYR A 292 26.187 27.099 27.003 1.00 63.29 N

ATOM 4352 CA TYR A 292 25.873 26.244 28.114 1.00 63.59 C

ATOM 4354 CB TYR A 292 25.605 27.105 29.361 1.00 63.27 C

ATOM 4357 CG TYR A 292 24.345 27.900 29.346 1.00 61.34 C

ATOM 4358 CDl TYR A 292 23.232 27.426 29.953 1.00 61.28 C

ATOM 4360 CEl TYR A 292 22.064 28.124 29.961 1.00 62.43 C

ATOM 4362 CZ TYR A 292 21.969 29.333 29.317 1.00 63.33 C

ATOM 4363 OH TYR A 292 20.753 30.010 29.369 1.00 61.75 O

ATOM 4365 CE2 TYR A 292 23.089 29.833 28.659 1.00 61.75 C

ATOM 4367 CD2 TYR A 292 24.269 29.109 28.695 1.00 61.15 C

ATOM 4369 C TYR A 292 24.680 25.364 27.824 1.00 63.55 C

ATOM 4370 O TYR A 292 23.902 25.665 26.944 1.00 61.46 O

ATOM 4371 N GLU A 293 24.514 24.283 28.594 1.00 65.22 N

ATOM 4373 CA GLU A 293 23.421 23.337 28.343 1.00 64.96 C

ATOM 4375 CB GLU A 293 23.822 21.946 28.802 1.00 66.42 C

ATOM 4378 CG GLU A 293 22.814 20.850 28.461 1.00 66.78 C

ATOM 4381 CD GLU A 293 23.357 19.453 28.686 1.00 68.32 C

ATOM 4382 OEl GLU A 293 24.573 19.284 28.917 1.00 66.66 O

ATOM 4383 OE2 GLU A 293 22.541 18.514 28.585 1.00 72.49 O

ATOM 4384 C GLU A 293 22.180 23.740 29.062 1.00 64.18 C

ATOM 4385 O GLU A 293 22.258 24.258 30.131 1.00 64.53 O

ATOM 4386 N MET A 294 21.037 23.444 28.482 1.00 64.06 N

ATOM 4388 CA MET A 294 19.735 23.773 29.048 1.00 64.77 C

ATOM 4390 CB MET A 294 19.444 25.230 28.817 1.00 64.63 C

ATOM 4393 CG MET A 294 19.548 25.564 27.386 1.00 65.21 C

ATOM 4396 SD MET A 294 18.161 26.233 26.768 1.00 67.82 S

ATOM 4397 CE MET A 294 18.225 27.967 27.430 1.00 68.39 C

ATOM 4401 C MET A 294 18.693 22.959 28.335 1.00 65.12 C

ATOM 4402 O MET A 294 19.053 22.135 27.553 1.00 66.70 O

ATOM 4403 N GLU A 295 17.409 23.178 28.560 1.00 66.08 N

ATOM 4405 CA GLU A 295 16.403 22.270 28.025 1.00 66.85 C

ATOM 4407 CB GLU A 295 16.105 21.144 29.030 1.00 68.03 C

ATOM 4410 CG GLU A 295 15.320 19.987 28.420 1.00 70.00 C

ATOM 4413 CD GLU A 295 15.183 18.715 29.276 1.00 72.37 C

ATOM 4414 OEl GLU A 295 15.186 18.767 30.490 1.00 69.76 O

ATOM 4415 OE2 GLU A 295 15.049 17.605 28.700 1.00 77.58 O

ATOM 4416 C GLU A 295 15.120 22.957 27.586 1.00 67.10 C

ATOM 4417 O GLU A 295 14.683 23.903 28.155 1.00 66.08 O

ATOM 4418 N GLU A 296 14.521 22.402 26.557 1.00 68.39 N

ATOM 4420 CA GLU A 296 13.398 22.997 25.876 1.00 69.98 C

ATOM 4422 CB GLU A 296 13.906 24.045 24.880 1.00 69.31 C ATOM 4425 CG GLO A 296 12.939 25.175 24.543 00 71.32 C

ATOM 4428 CD GLO A 296 13.505 26.317 23.613 00 72.51 C

ATOM 4429 OEl GLO A 296 14.592 26.270 22.931 00 67.50 O

ATOM 4430 OE2 GLO A 296 12.790 27.333 23.556 00 76.03 O

ATOM 4431 C GLO A 296 12.649 21.830 25.194 00 71.02 C

ATOM 4432 O GLO A 296 13.163 21.119 24.332 00 69.99 O

ATOM 4433 N ASP A 297 11.435 21.621 25.654 00 72.87 N

ATOM 4435 CA ASP A 297 10.564 20.526 25.225 00 74.19 C

ATOM 4437 CB ASP A 297 9.775 20.856 23.925 00 74.54 C

ATOM 4440 CG ASP A 297 8.253 20.479 24.078 1.00 78.91 C

ATOM 4441 ODl ASP A 297 7.709 19.556 23.383 00 80.68 O

ATOM 4442 OD2 ASP A 297 7.528 21.033 24.964 00 83.36 O

ATOM 4443 C ASP A 297 11.184 19.131 25.212 00 73.07 C

ATOM 4444 O ASP A 297 10.949 18.325 24.330 00 72.94 O

ATOM 4445 N GLY A 298 11.922 18.833 26.251 00 72.78 N

ATOM 4447 CA GLY A 298 12.585 17.537 26.330 00 72.97 C

ATOM 4450 C GLY A 298 13.754 17.408 25.377 00 71.57 C

ATOM 4451 O GLY A 298 14.020 16.324 24.868 00 72.37 O

ATOM 4452 N VAL A 299 14.432 18.524 25.111 00 70.39 N

ATOM 4454 CA VAL A 299 15.601 18.557 24.223 1.00 68.75 C

ATOM 4456 CB VAL A 299 15.264 19.209 22.862 1.00 .23 C

ATOM 4458 CGl VAL A 299 16.357 18.967 21.894 1.00 67.60 C

ATOM 4462 CG2 VAL A 299 13.917 18.716 22.298 1.00 68.94 C

ATOM 4466 C VAL A 299 16.718 19.382 24.871 1.00 67.74 C

ATOM 4467 O VAL A 299 16.573 20.574 25.068 1.00 66.87 O

ATOM 4468 N ARG A 300 17.821 18.729 25.220 1.00 67.57 N

ATOM 4470 CA ARG A 300 19.013 19.425 25.667 1.00 66.47 C

ATOM 4472 CB ARG A 300 19.957 18.390 26.324 1.00 67.22 C

ATOM 4481 C ARG A 300 19.626 20.231 24.437 1.00 64.86 C

ATOM 4482 O ARG A 300 19.911 19.629 23.366 1.00 63.66 O

ATOM 4483 N LYS A 301 19.757 21.576 24.594 1.00 63.56 N

ATOM 4485 CA LYS A 301 20.400 22.506 23.623 1.00 62.09 C

ATOM 4487 CB LYS A 301 19.365 23.446 23.014 1.00 61.81 C

ATOM 4490 CG LYS A 301 18.004 22.874 22.945 1.00 62.27 C

ATOM 4493 CD LYS A 301 17.127 23.599 21.987 1.00 62.22 C

ATOM 4496 CE LYS A 301 15.767 22.883 21.889 1.00 64.18 C

ATOM 4499 NZ LYS A 301 14.711 23.900 21.583 1.00 68.36 N

ATOM 4503 C LYS A 301 21.474 23.415 24.208 1.00 61.40 C

ATOM 4504 O LYS A 301 21.486 23.655 25.364 1.00 61.73 O

ATOM 4505 N CYS A 302 22.354 23.943 23.380 1.00 60.84 N

ATOM 4507 CA CYS A 302 23.324 24.956 23.768 1.00 61.35 C

ATOM 4509 CB CYS A 302 24.550 24.881 22.905 1.00 60.99 C

ATOM 4512 SG CYS A 302 25.368 23.314 23.146 1.00 67.99 S

ATOM 4513 C CYS A 302 22.794 26.275 23.482 1.00 60.63 C

ATOM 4514 O CYS A 302 22.523 26.536 22.363 1.00 62.04 O

ATOM 4515 N ALA A 303 22.657 27.119 24.472 1.00 60.94 N

ATOM 4517 CA ALA A 303 22.390 28.522 24.292 1.00 60.90 C

ATOM 4519 CB ALA A 303 21.236 28.950 25.251 1.00 60.91 C

ATOM 4523 C ALA A 303 23.723 29.290 24.565 1.00 61.01 C

ATOM 4524 O ALA A 303 24.608 28.755 25.162 1.00 61.07 O

ATOM 4525 N LYS A 304 23.867 30.532 24.114 1.00 61.74 N

ATOM 4527 CA LYS A 304 25.101 31.306 24.314 1.00 62.76 C

ATOM 4529 CB LYS A 304 25.383 32.328 23.177 1.00 62.14 C

ATOM 4536 C LYS A 304 24.981 32.007 25.672 1.00 63.58 C

ATOM 4537 O LYS A 304 23.927 32.573 26.016 1.00 62.97 O

ATOM 4538 N CYS A 305 26.067 31.947 26.441 1.00 64.37 N

ATOM 4540 CA CYS A 305 26.054 32.434 27.809 1.00 64.66 C

ATOM 4542 CB CYS A 305 27.392 32.217 28.470 1.00 65.21 C

ATOM 4545 SG CYS A 305 27.739 30.498 28.766 1.00 63.94 S

ATOM 4546 C CYS A 305 25.781 33.878 27.864 1.00 64.83 C

ATOM 4547 O CYS A 305 26.343 34.630 27.095 1.00 64.68 O

ATOM 4548 N GLO A 306 24.936 34.253 28.814 1.00 66.05 N

ATOM 4550 CA GLO A 306 24.524 35.644 29.001 1.00 66.80 C

ATOM 4552 CB GLO A 306 23.563 35.751 30.202 1.00 66.67 C

ATOM 4559 C GLO A 306 25.812 36.489 29.193 1.00 67.43 C

ATOM 4560 O GLO A 306 26.353 37.052 28.177 1.00 68.24 O

ATOM 4561 N GLY A 307 26.321 36.534 30.441 1.00 65.77 N

ATOM 4563 CA GLY A 307 27.647 37.068 30.683 1.00 65.67 C ATOM 4566 C GLY A 307 28.789 36.058 30.514 1 . 00 65 . 77 C

ATOM 4567 O GLY A 307 28.749 35.218 29.655 1 . 00 66. 29 O

ATOM 4568 N PRO A 308 29.826 36.129 31.345 00 65 . 73 N

ATOM 4569 CA PRO A 308 30.736 34.998 31.452 00 65 . 66 C

ATOM 4571 CB PRO A 308 31.671 35.399 32.609 00 66. 34 C

ATOM 4574 CG PRO A 308 31.364 36.818 32.999 00 65.33 C

ATOM 4577 CD PRO A 308 30.197 37.256 32.246 00 65.52 C

ATOM 4580 C PRO A 308 29.978 33.708 31.807 00 64 . 49 C

ATOM 4581 O PRO A 308 29.013 33.700 32.535 00 63. 44 O

ATOM 4582 N CYS A 309 30.438 32.594 31.299 00 64 . 85 N

ATOM 4584 CA CYS A 309 29.805 31.354 31.627 00 64 . 54 C

ATOM 4586 CB CYS A 309 30.386 30.212 30.830 00 65.21 C

ATOM 4589 SG CYS A 309 29.788 30.212 29.155 00 66.57 S

ATOM 4590 C CYS A 309 29.997 31.025 33.032 00 64 . 83 C

ATOM 4591 O CYS A 309 30.976 31.344 33.634 00 65. 61 O

ATOM 4592 N ARG A 310 29.058 30.285 33.547 00 60.31 N

ATOM 4594 CA ARG A 310 29.113 29.882 34.923 00 57 . 41 C

ATOM 4596 CB ARG A 310 27.799 29.192 35.275 00 58. 70 C

ATOM 4599 CG ARG A 310 27.864 28.223 36.449 00 59.00 C

ATOM 4602 CD ARG A 310 26.495 27.931 37.089 00 61. 96 C

ATOM 4605 NE ARG A 310 26.526 28.291 38.498 00 59. 13 N

ATOM 4607 CZ ARG A 310 26.658 27.437 39.485 00 58. 19 C

ATOM 4608 NHl ARG A 310 26.733 26.108 39.288 00 62.56 N

ATOM 4611 NH2 ARG A 310 26.687 27.939 40.688 00 54 . 22 N

ATOM 4614 C ARG A 310 30.266 28.956 35.092 00 56.38 C

ATOM 4615 O ARG A 310 30.384 27.970 34.367 00 60. 06 O

ATOM 4616 N LYS A 311 31.077 29.253 36.067 00 52. 95 N

ATOM 4618 CA LYS A 311 32.237 28.466 36.405 00 53.16 C

ATOM 4620 CB LYS A 311 33.489 29.100 35.809 1.00 53.22 C

ATOM 4623 CG LYS A 311 34.691 28.185 35.636 .00 54 .72 C

ATOM 4626 CD LYS A 311 35.994 28.877 36.020 .00 54 . 84 C

ATOM 4629 CE LYS A 311 37.190 28.137 35.562 .00 55. 94 C

ATOM 4632 NZ LYS A 311 37.492 28.559 34.153 .00 61.52 N

ATOM 4636 C LYS A 311 32.370 28.399 37.919 1.00 51. 04 C

ATOM 4637 O LYS A 311 32.461 29.412 38.626 1.00 48. 96 O

ATOM 4638 N VAL A 312 32.389 27.190 38.441 1.00 52.10 N

ATOM 4640 CA VAL A 312 32.387 27.022 39.879 1.00 49. 43 C

ATOM 4642 CB VAL A 312 31.419 25.856 40.214 1.00 51. 43 C

ATOM 4644 CGl VAL A 312 31.644 25.299 41.629 1.00 51.31 C

ATOM 4648 CG2 VAL A 312 29.941 26.303 40.019 00 51. 87 C

ATOM 4652 C VAL A 312 33.810 26.792 40.321 00 47 . 46 C

ATOM 4653 O VAL A 312 34.534 26.134 39.633 00 48. 81 O

ATOM 4654 N CYS A 313 34.224 27.342 41.452 00 45. 64 N

ATOM 4656 CA CYS A 313 35.603 27.139 41.985 00 46.21 C

ATOM 4658 CB CYS A 313 36.533 28.305 41.639 00 45. 10 C

ATOM 4661 SG CYS A 313 36.511 28.703 39.843 00 55 . 4 6 S

ATOM 4662 C CYS A 313 35.674 26.972 43.482 00 44 . 15 C

ATOM 4663 O CYS A 313 35.043 27.684 44.222 1.00 44 .. 97 O

ATOM 4664 N ASN A 314 36.502 26.078 43.951 1.00 44 . 46 N

ATOM 4666 CA ASN A 314 36.817 25.995 45.346 1.00 42 .36 C

ATOM 4668 CB ASN A 314 37.915 24.968 45.553 1.00 43. 90 C

ATOM 4671 CG ASN A 314 37.515 23.563 45.052 1.00 46. 81 C

ATOM 4672 ODl ASN A 314 36.465 23.016 45.453 1.00 50.58 O

ATOM 4673 ND2 ASN A 314 38.309 23.026 44.099 1.00 49.45 N

ATOM 4676 C ASN A 314 37.278 27.306 45.972 1.00 40. 41 C

ATOM 4677 O ASN A 314 37.974 28.140 45.385 1.00 40. 47 O

ATOM 4678 N GLY A 315 36.860 27.494 47.209 1.00 39. 42 N

ATOM 4680 CA GLY A 315 37.329 28.597 47.998 1.00 36. 84 C

ATOM 4683 C GLY A 315 38.633 28.342 48.697 1.00 36.39 C

ATOM 4684 O GLY A 315 39.321 27.340 48.580 1.00 36.34 O

ATOM 4685 N ILE A 316 38.975 29.319 49.483 1.00 35. 62 N

ATOM 4687 CA ILE A 316 40.197 29.200 50.208 1.00 36. 69 C

ATOM 4689 CB ILE A 316 40.615 30.542 50.613 1.00 34 . 84 C

ATOM 4691 CGl ILE A 316 41.327 31.048 49.383 1.00 37 . 92 C

ATOM 4694 CDl ILE A 316 41.400 32.434 49.319 1.00 40. 69 C

ATOM 4698 CG2 ILE A 316 41.647 30.485 51.734 1.00 34 . 92 C

ATOM 4702 C ILE A 316 40.093 28.246 51.344 00 37 . 13 C

ATOM 4703 O ILE A 316 39.246 28.398 52.197 1.00 36. 17 O ATOM 4704 N GLY A 317 40.969 27.271 51.351 1.00 38.50 N

ATOM 4706 CA GLY A 317 40.937 26.289 52.410 1.00 40.78 C

ATOM 4709 C GLY A 317 40.864 24.924 51.786 1.00 43.80 C

ATOM 4710 O GLY A 317 41.628 23.995 52.149 1.00 46.54 O

ATOM 4711 N ILE A 318 40.026 24.860 50.760 1.00 43.85 N

ATOM 4713 CA ILE A 318 39.762 23.645 49.983 1.00 46.17 C

ATOM 4715 CB ILE A 318 38.287 23.658 49.611 1.00 45.60 C

ATOM 4717 CGl ILE A 318 37.441 23.639 50.888 1.00 43.98 C

ATOM 4720 CDl ILE A 318 36.125 24.137 50.662 1.00 43.89 C

ATOM 4724 CG2 ILE A 318 38.020 22.487 48.661 1.00 47.89 C

ATOM 4728 C ILE A 318 40.520 23.509 48.639 1.00 47.63 C

ATOM 4729 O ILE A 318 40.833 24.543 48.012 1.00 46.75 O

ATOM 4730 N GLY A 319 40.735 22.254 48.176 1.00 49.13 N

ATOM 4732 CA GLY A 319 41.097 21.976 46.806 1.00 49.93 C

ATOM 4735 C GLY A 319 42.480 22.498 46.473 1.00 50.82 C

ATOM 4736 O GLY A 319 43.460 22.255 47.179 1.00 50.60 O

ATOM 4737 N GLU A 320 42.574 23.195 45.349 1.00 51.94 N

ATOM 4739 CA GLU A 320 43.811 23.859 44.916 1.00 52.89 C

ATOM 4741 CB GLU A 320 43.504 24.771 43.735 1.00 53.88 C

ATOM 4744 CG GLU A 320 42.802 24.123 42.555 1.00 59.54 C

ATOM 4747 CD GLU A 320 41.252 24.262 42.562 1.00 63.07 C

ATOM 4748 OEl GLU A 320 40.603 24.715 43.485 1.00 57.30 O

ATOM 4749 OE2 GLU A 320 40.630 23.836 41.573 1.00 75.97 O

ATOM 4750 C GLU A 320 44.342 24.781 46.010 1.00 50.87 C

ATOM 4751 O GLU A 320 45.521 25.097 46.022 1.00 52.50 O

ATOM 4752 N TYR A 321 43.445 25.243 46.893 1.00 47.74 N

ATOM 4754 CA TYR A 321 43.796 25.996 48.048 1.00 45.39 C

ATOM 4756 CB TYR A 321 42.903 27.163 48.113 1.00 43.88 C

ATOM 4759 CG TYR A 321 42.549 27.735 46.790 1.00 47.78 C

ATOM 4760 CDl TYR A 321 41.299 27.545 46.250 1.00 51.91 C

ATOM 4762 CEl TYR A 321 40.963 28.042 45.044 1.00 54.97 C

ATOM 4764 CZ TYR A 321 41.861 28.800 44.366 1.00 58.00 C

ATOM 4765 OH TYR A 321 41.452 29.315 43.136 1.00 61.65 O

ATOM 4767 CE2 TYR A 321 43.129 29.019 44.881 1.00 55.75 C

ATOM 4769 CD2 TYR A 321 43.461 28.453 46.077 1.00 54.38 C

ATOM 4771 C TYR A 321 43.715 25.308 49.398 1.00 45.37 C

ATOM 4772 O TYR A 321 43.438 25.950 50.371 1.00 42.50 O

ATOM 4773 N LYS A 322 44.043 24.018 49.489 1.00 49.57 N

ATOM 4775 CA LYS A 322 44.267 23.354 50.814 1.00 50.70 C

ATOM 4777 CB LYS A 322 44.619 21.795 50.737 1.00 52.77 C

ATOM 4784 C LYS A 322 45.384 24.199 51.513 1.00 49.99 C

ATOM 4785 O LYS A 322 46.427 24.525 50.921 1.00 51.02 O

ATOM 4786 N ASP A 323 45.144 24.600 52.746 1.00 48.30 N

ATOM 4788 CA ASP A 323 46.253 25.036 53.583 1.00 47.80 C

ATOM 4790 CB ASP A 323 47.442 24.075 53.481 1.00 51.14 C

ATOM 4793 CG ASP A 323 47.180 22.729 54.109 1.00 53.64 C

ATOM 4794 ODl ASP A 323 46.376 22.621 55.075 1.00 52.75 O

ATOM 4795 OD2 ASP A 323 47.796 21.713 53.701 1.00 58.75 O

ATOM 4796 C ASP A 323 46.770 26.367 53.240 1.00 45.65 C

ATOM 4797 O ASP A 323 47.821 26.714 53.723 1.00 47.47 O

ATOM 4798 N SER A 324 46.044 27.125 52.438 1.00 43.32 N

ATOM 4800 CA SER A 324 46.390 28.510 52.161 1.00 41.79 C

ATOM 4802 CB SER A 324 46.201 28.796 50.677 1.00 42.47 C

ATOM 4805 OG SER A 324 45.674 27.663 50.062 1.00 45.77 O

ATOM 4807 C SER A 324 45.537 29.476 52.905 1.00 37.75 C

ATOM 4808 O SER A 324 44.411 29.412 52.773 1.00 37.31 O

ATOM 4809 N LEU A 325 46.096 30.432 53.610 1.00 37.13 N

ATOM 4811 CA LEU A 325 45.334 31.298 54.493 1.00 35.04 C

ATOM 4813 CB LEU A 325 46.238 32.059 55.405 1.00 35.20 C

ATOM 4816 CG LEU A 325 47.124 31.230 56.304 1.00 38.21 C

ATOM 4818 CDl LEU A 325 48.006 32.088 57.155 1.00 38.14 C

ATOM 4822 CD2 LEU A 325 46.216 30.335 57.130 1.00 38.92 C

ATOM 4826 C LEU A 325 44.533 32.325 53.776 1.00 33.99 C

ATOM 4827 O LEU A 325 43.445 32.619 54.178 1.00 32.49 O

ATOM 4828 N SER A 326 45.048 32.884 52.693 1.00 35.06 N

ATOM 4830 CA SER A 326 44.248 33.883 51.961 1.00 32.80 C

ATOM 4832 CB SER A 326 44.583 35.203 52.587 1.00 31.79 C

ATOM 4835 OG SER A 326 44.971 36.156 51.666 1.00 32.01 O ATOM 4837 C SER A 326 44.404 33.929 50.432 1.00 33.06 C

ATOM 4838 O SER A 326 45.192 33.247 49.857 1.00 33.84 O

ATOM 4839 N ILE A 327 43.595 34.725 49.773 1.00 32.82 N

ATOM 4841 CA ILE A 327 43.767 34.943 48.360 1.00 34.47 C

ATOM 4843 CB ILE A 327 42.689 35.862 47.848 1.00 34.82 C

ATOM 4845 CGl ILE A 327 41.498 35.102 47.344 1.00 36.75 C

ATOM 4848 CDl ILE A 327 40.210 35.936 47.450 1.00 39.37 C

ATOM 4852 CG2 ILE A 327 43.072 36.537 46.591 1.00 38.67 C

ATOM 4856 C ILE A 327 45.050 35.640 48.320 1.00 34.57 C

ATOM 4857 O ILE A 327 45.288 36.446 49.182 1.00 34.42 O

ATOM 4858 N ASN A 328 45.886 35.347 47.332 1.00 36.41 N

ATOM 4860 CA ASN A 328 47.298 35.754 47.372 1.00 37.37 C

ATOM 4862 CB ASN A 328 48.002 35.038 48.522 1.00 37.48 C

ATOM 4865 CG ASN A 328 48.542 33.692 48.173 1.00 39.49 C

ATOM 4866 ODl ASN A 328 49.033 33.448 47.064 1.00 46.88 O

ATOM 4867 ND2 ASN A 328 48.542 32.803 49.165 1.00 39.97 N

ATOM 4870 C ASN A 328 48.051 35.653 46.050 1.00 39.52 C

ATOM 4871 O ASN A 328 47.569 35.036 45.117 1.00 40.76 O

ATOM 4872 N ALA A 329 49.204 36.297 45.922 1.00 41.21 N

ATOM 4874 CA ALA A 329 49.894 36.340 44.585 1.00 44.38 C

ATOM 4876 CB ALA A 329 51.307 36.867 44.702 1.00 46.80 C

ATOM 4880 C ALA A 329 49.981 35.028 43.836 1.00 45.40 C

ATOM 4881 O ALA A 329 49.799 34.986 42.642 1.00 45.54 O

ATOM 4882 N THR A 330 50.308 33.986 44.577 1.00 45.70 N

ATOM 4884 CA THR A 330 50.416 32.677 44.025 1.00 48.70 C

ATOM 4886 CB THR A 330 50.997 31.669 45.089 1.00 49.87 C

ATOM 4888 OGl THR A 330 52.331 32.048 45.543 1.00 51.51 O

ATOM 4890 CG2 THR A 330 51.204 30.298 44.458 1.00 50.43 C

ATOM 4894 C THR A 330 49.057 32.212 43.479 1.00 47.89 C

ATOM 4895 O THR A 330 48.914 31.950 42.295 1.00 51.27 O

ATOM 4896 N ASN A 331 48.053 32.168 44.321 1.00 44.82 N

ATOM 4898 CA ASN A 331 46.806 31.518 43.978 1.00 43.96 C

ATOM 4900 CB ASN A 331 46.163 30.942 45.241 1.00 41.18 C

ATOM 4903 CG ASN A 331 45.825 32.001 46.294 1.00 38.02 C

ATOM 4904 ODl ASN A 331 45.247 33.040 46.021 1.00 35.91 O

ATOM 4905 ND2 ASN A 331 46.133 31.684 47.528 1.00 38.74 N

ATOM 4908 C ASN A 331 45.750 32.358 43.246 1.00 44.04 C

ATOM 4909 O ASN A 331 44.746 31.828 42.838 1.00 43.86 O

ATOM 4910 N ILE A 332 45.930 33.662 43.099 1.00 43.98 N

ATOM 4912 CA ILE A 332 44.823 34.466 42.632 1.00 42.84 C

ATOM 4914 CB ILE A 332 45.126 35.929 42.836 1.00 42.58 C

ATOM 4916 CGl ILE A 332 44.037 36.797 42.283 1.00 44.23 C

ATOM 4919 CDl ILE A 332 43.052 37.052 43.195 1.00 43.72 C

ATOM 4923 CG2 ILE A 332 46.249 36.384 42.012 1.00 47.11 C

ATOM 4927 C ILE A 332 44.578 34.128 41.178 1.00 45.50 C

ATOM 4928 O ILE A 332 43.489 34.240 40.691 1.00 45.59 O

ATOM 4929 N LYS A 333 45.597 33.700 40.442 1.00 49.20 N

ATOM 4931 CA LYS A 333 45.375 33.357 39.021 1.00 51.11 C

ATOM 4933 CB LYS A 333 46.690 33.013 38.339 1.00 54.36 C

ATOM 4936 CG LYS A 333 47.406 31.694 38.725 1.00 57.01 C

ATOM 4939 CD LYS A 333 48.821 31.590 37.959 1.00 62.54 C

ATOM 4942 CE LYS A 333 49.910 30.629 38.656 1.00 65.67 C

ATOM 4945 NZ LYS A 333 50.727 29.668 37.638 1.00 68.40 N

ATOM 4949 C LYS A 333 44.323 32.280 38.822 1.00 50.34 C

ATOM 4950 O LYS A 333 43.582 32.338 37.868 1.00 51.26 O

ATOM 4951 N HIS A 334 44.258 31.317 39.738 1.00 49.08 N

ATOM 4953 CA HIS A 334 43.312 30.206 39.685 1.00 49.27 C

ATOM 4955 CB HIS A 334 43.659 29.165 40.744 1.00 48.44 C

ATOM 4958 CG HIS A 334 44.980 28.524 40.539 1.00 53.18 C

ATOM 4959 NDl HIS A 334 45.158 27.442 39.698 1.00 59.88 N

ATOM 4961 CEl HIS A 334 46.441 27.119 39.674 1.00 62.27 C

ATOM 4963 NE2 HIS A 334 47.095 27.941 40.481 1.00 59.52 N

ATOM 4965 CD2 HIS A 334 46.199 28.819 41.045 1.00 54.75 C

ATOM 4967 C HIS A 334 41.853 30.601 39.909 1.00 47.75 C

ATOM 4968 O HIS A 334 40.986 29.750 39.847 1.00 48.67 O

ATOM 4969 N PHE A 335 41.579 31.874 40.217 1.00 46.14 N

ATOM 4971 CA PHE A 335 40.196 32.413 40.254 1.00 44.55 C

ATOM 4973 CB PHE A 335 40.053 33.427 41.378 1.00 41.24 C ATOM 4976 CG PHE A 335 40.055 32.827 42.681 1..00 39.32 C

ATOM 4977 CDl PHE A 335 41.223 32.551 43.307 1..00 39.57 C

ATOM 4979 CEl PHE A 335 41.222 31.936 44.525 1..00 40.84 C

ATOM 4981 CZ PHE A 335 40.043 31.617 45.104 1..00 41.14 C

ATOM 4983 CE2 PHE A 335 38.863 31.842 44.455 1..00 40.09 C

ATOM 4985 CD2 PHE A 335 38.876 32.428 43.255 1..00 40.14 C

ATOM 4987 C PHE A 335 39.687 33.101 38.960 1..00 46.58 C

ATOM 4988 O PHE A 335 38.620 33.706 39.041 1..00 45.62 O

ATOM 4989 N LYS A 336 40.399 32.984 37.819 1..00 48.98 N

ATOM 4991 CA LYS A 336 40.046 33.678 36.590 1..00 51.49 C

ATOM 4993 CB LYS A 336 41.121 33.576 35.481 1..00 53.28 C

ATOM 5000 C LYS A 336 38.721 33.111 36.086 1..00 53.24 C

ATOM 5001 O LYS A 336 38.578 31.885 35.942 1..00 55.91 O

ATOM 5002 N ASN A 337 37.749 33.990 35.837 1..00 52.95 N

ATOM 5004 CA ASN A 337 36.461 33.566 35.321 1..00 54.28 C

ATOM 5006 CB ASN A 337 36.652 32.725 34.105 1..00 57.90 C

ATOM 5009 CG ASN A 337 37.513 33.373 33.127 1..00 61.13 C

ATOM 5010 ODl ASN A 337 37.278 34.525 32.791 1..00 60.64 O

ATOM 5011 ND2 ASN A 337 38.553 32.662 32.664 1..00 67.20 N

ATOM 5014 C ASN A 337 35.581 32.785 36.259 1..00 52.45 C

ATOM 5015 O ASN A 337 34.540 32.290 35.832 1..00 52.89 O

ATOM 5016 N CYS A 338 35.970 32.691 37.527 1..00 49.80 N

ATOM 5018 CA CYS A 338 35.126 32.034 38.473 1..00 49.56 C

ATOM 5020 CB CYS A 338 35.803 31.803 39.799 1..00 47.52 C

ATOM 5023 SG CYS A 338 37.211 30.611 39.508 1..00 59.20 S

ATOM 5024 C CYS A 338 33.979 32.932 38.628 1..00 47.35 C

ATOM 5025 O CYS A 338 34.130 34.149 38.726 1..00 46.23 O

ATOM 5026 N THR A 339 32.834 32.301 38.627 1..00 46.93 N

ATOM 5028 CA THR A 339 31.599 32.968 38.809 .00 47.23 C

ATOM 5030 CB THR A 339 30.770 32.593 37.622 .00 50.51 C

ATOM 5032 OGl THR A 339 30.642 33.782 36.857 1.00 53.34 O

ATOM 5034 CG2 THR A 339 29.337 32.064 37.962 1.00 50.61 C

ATOM 5038 C THR A 339 30.930 32.648 40.135 1.00 45.18 C

ATOM 5039 O THR A 339 30.247 33.470 40.689 1.00 44.47 O

ATOM 5040 N SER A 340 31.129 31.439 40.632 1.00 45.15 N

ATOM 5042 CA SER A 340 30.623 31.025 41.933 1.00 43.31 C

ATOM 5044 CB SER A 340 29.379 30.132 41.733 1.00 45.83 C

ATOM 5047 OG SER A 340 29.249 29.081 42.698 1.00 44.04 O

ATOM 5049 C SER A 340 31.702 30.248 42.678 1.00 41.72 C

ATOM 5050 O SER A 340 32.352 29.358 42.130 1.00 43.56 O

ATOM 5051 N ILE A 341 31.840 30.554 43.938 1.00 38.97 N

ATOM 5053 CA ILE A 341 32.891 30.013 44.722 1.00 38.11 C

ATOM 5055 CB ILE A 341 33.577 31.124 45.410 00 36.26 C

ATOM 5057 CGl ILE A 341 34.447 31.785 44.365 00 37.48 C

ATOM 5060 CDl ILE A 341 34.986 32.997 44.783 1.00 39.65 C

ATOM 5064 CG2 ILE A 341 34.370 30.578 46.573 00 36.38 C

ATOM 5068 C ILE A 341 32.279 29.147 45.704 00 38.22 C

ATOM 5069 O ILE A 341 31.424 29.588 46.497 1.00 36.50 O

ATOM 5070 N SER A 342 32.702 27.897 45.679 1.00 40.02 N

ATOM 5072 CA SER A 342 32.138 26.946 46.612 1.00 41.56 C

ATOM 5074 CB SER A 342 31.753 25.639 45.909 1.00 44.24 C

ATOM 5077 OG SER A 342 32.513 24.550 46.357 1.00 49.61 O

ATOM 5079 C SER A 342 33.114 26.871 47.782 1.00 39.51 C

ATOM 5080 O SER A 342 34.143 26.269 47.719 1.00 40.40 O

ATOM 5081 N GLY A 343 32.762 27.578 48.840 00 38.27 N

ATOM 5083 CA GLY A 343 33.645 27.834 49.938 00 37.00 C

ATOM 5086 C GLY A 343 33.681 29.322 50.263 1.00 35.53 C

ATOM 5087 O GLY A 343 32.754 30.074 49.877 1.00 34.59 O

ATOM 5088 N ASP A 344 34.775 29.727 50.970 1.00 34.54 N

ATOM 5090 CA ASP A 344 34.920 31.070 51.544 00 32.00 C

ATOM 5092 CB ASP A 344 35.234 30.977 53.032 00 31.72 C

ATOM 5095 CG ASP A 344 34.574 29.830 53.703 00 34.32 C

ATOM 5096 ODl ASP A 344 33.317 29.772 53.622 00 41.66 O

ATOM 5097 OD2 ASP A 344 35.178 28.928 54.346 1.00 35.55 O

ATOM 5098 C ASP A 344 36.025 31.826 50.797 00 30.48 C

ATOM 5099 O ASP A 344 36.853 31.209 50.204 00 31.17 O

ATOM 5100 N LED A 345 35.995 33.146 50.824 1.00 28.65 N

ATOM 5102 CA LEU A 345 37.056 33.969 50.344 1.00 29.65 C ATOM 5104 CB LEU A 345 36.479 34.951 49.381 1.00 31.28 C

ATOM 5107 CG LEU A 345 36.877 35.111 47.916 1.00 34.49 C

ATOM 5109 CDl LEU A 345 37.260 33.825 47.393 1.00 39.14 C

ATOM 5113 CD2 LEU A 345 35.690 35.571 47.155 1.00 33.77 C

ATOM 5117 C LEU A 345 37.580 34.737 51.548 1.00 29.18 C

ATOM 5118 O LEU A 345 36.784 35.296 52.295 1.00 29.37 O

ATOM 5119 N HIS A 346 38.882 34.655 51.810 1.00 29.00 N

ATOM 5121 CA HIS A 346 39.552 35.409 52.838 1.00 28.13 C

ATOM 5123 CB HIS A 346 40.486 34.542 53.655 1.00 29.47 C

ATOM 5126 CG HIS A 346 39.875 33.338 54.278 1.00 30.10 C

ATOM 5127 NDl HIS A 346 38.833 33.396 55.118 1.00 35.14 N

ATOM 5129 CEl HIS A 346 38.538 32.196 55.572 1.00 35.47 C

ATOM 5131 NE2 HIS A 346 39.391 31.361 55.089 1.00 32.97 N

ATOM 5133 CD2 HIS A 346 40.268 32.060 54.311 1.00 36.36 C

ATOM 5135 C HIS A 346 40.552 36.345 52.173 1.00 29.15 C

ATOM 5136 O HIS A 346 41.448 35.896 51.405 1.00 29.88 O

ATOM 5137 N ILE A 347 40.509 37.629 52.497 1.00 28.56 N

ATOM 5139 CA ILE A 347 41.537 38.505 52.005 1.00 28.80 C

ATOM 5141 CB ILE A 347 40.914 39.548 51.175 1.00 28.20 C

ATOM 5143 CGl ILE A 347 40.355 38.876 49.939 1.00 28.97 C

ATOM 5146 CDl ILE A 347 39.286 39.729 49.225 1.00 31.16 C

ATOM 5150 CG2 ILE A 347 41.951 40.589 50.781 1.00 29.70 C

ATOM 5154 C ILE A 347 42.248 39.072 53.183 1.00 28.89 C

ATOM 5155 O ILE A 347 41.697 39.924 53.810 1.00 29.99 O

ATOM 5156 N LEU A 348 43.443 38.605 53.524 1.00 30.00 N

ATOM 5158 CA LEU A 348 44.077 39.025 54.787 1.00 30.57 C

ATOM 5160 CB LEU A 348 44.555 37.886 55.605 1.00 30.53 C

ATOM 5163 CG LEU A 348 43.596 36.715 55.576 1.00 31.50 C

ATOM 5165 CDl LEU A 348 44.246 35.482 56.211 1.00 32.92 C

ATOM 5169 CD2 LEU A 348 42.330 37.083 56.215 1.00 31.99 C

ATOM 5173 C LEU A 348 45.246 39.881 54.475 1.00 32.43 C

ATOM 5174 O LEU A 348 45.607 39.970 53.337 1.00 34.49 O

ATOM 5175 N PRO A 349 45.778 40.592 55.455 1.00 32.87 N

ATOM 5176 CA PRO A 349 46.973 41.381 55.264 1.00 33.99 C

ATOM 5178 CB PRO A 349 47.271 41.886 56.659 1.00 34.22 C

ATOM 5181 CG PRO A 349 45.966 42.137 57.153 1.00 34.18 C

ATOM 5184 CD PRO A 349 45.163 40.881 56.755 1.00 32.82 C

ATOM 5187 C PRO A 349 48.124 40.614 54.726 1.00 35.54 C

ATOM 5188 O PRO A 349 48.893 41.228 53.933 1.00 37.23 O

ATOM 5189 N VAL A 350 48.295 39.356 55.124 1.00 35.44 N

ATOM 5191 CA VAL A 350 49.450 38.608 54.559 1.00 37.52 C

ATOM 5193 CB VAL A 350 49.454 37.117 54.856 1.00 37.63 C

ATOM 5195 CGl VAL A 350 50.325 36.871 55.983 1.00 39.53 C

ATOM 5199 CG2 VAL A 350 48.030 36.560 55.008 1.00 35.14 C

ATOM 5203 C VAL A 350 49.551 38.672 53.016 1.00 37.28 C

ATOM 5204 O VAL A 350 50.644 38.668 52.452 1.00 37.00 O

ATOM 5205 N ALA A 351 48.386 38.692 52.387 1.00 34.61 N

ATOM 5207 CA ALA A 351 48.304 38.858 50.982 1.00 35.88 C

ATOM 5209 CB ALA A 351 46.880 39.055 50.584 1.00 34.44 C

ATOM 5213 C ALA A 351 49.136 40.024 50.514 1.00 37.47 C

ATOM 5214 O ALA A 351 50.006 39.864 49.710 1.00 38.97 O

ATOM 5215 N PHE A 352 48.843 41.210 51.010 1.00 37.79 N

ATOM 5217 CA PHE A 352 49.495 42.407 50.491 1.00 39.28 C

ATOM 5219 CB PHE A 352 48.674 43.607 50.839 1.00 37.35 C

ATOM 5222 CG PHE A 352 47.296 43.459 50.390 1.00 35.68 C

ATOM 5223 CDl PHE A 352 46.310 43.146 51.249 1.00 35.62 C

ATOM 5225 CEl PHE A 352 45.040 42.971 50.821 1.00 35.56 C

ATOM 5227 CZ PHE A 352 44.760 43.037 49.504 1.00 37.20 C

ATOM 5229 CE2 PHE A 352 45.774 43.277 48.616 1.00 38.11 C

ATOM 5231 CD2 PHE A 352 47.016 43.468 49.070 1.00 38.39 C

ATOM 5233 C PHE A 352 50.912 42.564 50.942 1.00 42.10 C

ATOM 5234 O PHE A 352 51.661 43.264 50.308 1.00 45.13 O

ATOM 5235 N ARG A 353 51.318 41.916 52.018 1.00 42.10 N

ATOM 5237 CA ARG A 353 52.706 42.048 52.408 1.00 44.35 C

ATOM 5239 CB ARG A 353 52.810 42.476 53.863 1.00 44.18 C

ATOM 5242 CG ARG A 353 52.838 41.475 54.889 1.00 45.56 C

ATOM 5245 CD ARG A 353 52.340 41.993 56.328 1.00 46.05 C

ATOM 5248 NE ARG A 353 51.908 40 . 792 57 . 076 1 . 00 48 . 23 N ATOM 5250 CZ ARG A 353 50.904 40.702 57.958 1.00 49.69 C

ATOM 5251 NHl ARG A 353 50.159 41.766 58.367 1.00 48.00 N

ATOM 5254 NH2 ARG A 353 50.644 39.490 58.462 1.00 51.85 N

ATOM 5257 C ARG A 353 53.606 40.883 52.034 1.00 45.87 C

ATOM 5258 O ARG A 353 54.793 40.995 52.113 1.00 49.79 O

ATOM 5259 N GLY A 354 53.077 39.819 51.471 1.00 44.58 N

ATOM 5261 CA GLY A 354 53.844 38.608 51.326 1.00 45.57 C

ATOM 5264 C GLY A 354 54.077 37.881 52.646 1.00 45.59 C

ATOM 5265 O GLY A 354 53.795 38.404 53.757 1.00 44.40 O

ATOM 5266 N ASP A 355 54.560 36.657 52.489 1.00 47.02 N

ATOM 5268 CA ASP A 355 54.875 35.747 53.559 1.00 49.26 C

ATOM 5270 CB ASP A 355 53.675 34.810 53.761 1.00 47.45 C

ATOM 5273 CG ASP A 355 53.819 33.857 54.999 1.00 52.55 C

ATOM 5274 ODl ASP A 355 54.748 33.966 55.843 1.00 52.58 O

ATOM 5275 OD2 ASP A 355 52.964 32.945 55.218 1.00 57.12 O

ATOM 5276 C ASP A 355 56.184 34.963 53.184 1.00 52.90 C

ATOM 5277 O ASP A 355 56.230 34.283 52.193 1.00 53.38 O

ATOM 5278 N SER A 356 57.257 35.097 53.951 1.00 55.22 N

ATOM 5280 CA SER A 356 58.449 34.379 53.620 1.00 59.39 C

ATOM 5282 CB SER A 356 59.693 35.013 54.276 1.00 62.91 C

ATOM 5285 OG SER A 356 59.657 34.911 55.688 1.00 63.67 O

ATOM 5287 C SER A 356 58.280 32.920 54.042 1.00 59.92 C

ATOM 5288 O SER A 356 58.935 31.998 53.497 1.00 62.62 O

ATOM 5289 N PHE A 357 57.411 32.695 55.015 1.00 57.30 N

ATOM 5291 CA PHE A 357 57.303 31.355 55.591 1.00 58.59 C

ATOM 5293 CB PHE A 357 56.605 31.427 56.964 1.00 57.36 C

ATOM 5296 CG PHE A 357 57.294 32.421 57.919 1.00 60.90 C

ATOM 5297 CDl PHE A 357 56.748 33.697 58.164 1.00 59.90 C

ATOM 5299 CEl PHE A 357 57.381 34.597 59.001 1.00 62.61 C

ATOM 5301 CZ PHE A 357 58.620 34.277 59.612 1.00 66.42 C

ATOM 5303 CE2 PHE A 357 59.197 33.034 59.358 1.00 70.78 C

ATOM 5305 CD2 PHE A 357 58.530 32.102 58.516 1.00 68.20 C

ATOM 5307 C PHE A 357 56.638 30.400 54.612 1.00 57.26 C

ATOM 5308 O PHE A 357 56.959 29.213 54.566 1.00 59.38 O

ATOM 5309 N THR A 358 55.781 30.990 53.792 1.00 53.74 N

ATOM 5311 CA THR A 358 54.993 30.317 52.788 1.00 52.07 C

ATOM 5313 CB THR A 358 53.638 30.968 52.871 1.00 48.69 C

ATOM 5315 OGl THR A 358 52.917 30.251 53.847 1.00 49.41 O

ATOM 5317 CG2 THR A 358 52.782 30.701 51.766 1.00 49.09 C

ATOM 5321 C THR A 358 55.512 30.469 51.384 1.00 52.42 C

ATOM 5322 O THR A 358 54.936 29.873 50.469 1.00 50.78 O

ATOM 5323 N HIS A 359 56.595 31.258 51.252 1.00 53.66 N

ATOM 5325 CA HIS A 359 57.166 31.739 49.989 1.00 54.99 C

ATOM 5327 CB HIS A 359 57.756 30.604 49.243 1.00 57.50 C

ATOM 5330 CG HIS A 359 58.370 29.588 50.107 1.00 58.68 C

ATOM 5331 NDl HIS A 359 59.709 29.584 50.363 1.00 63.58 N

ATOM 5333 CEl HIS A 359 60.000 28.539 51.119 1.00 64.70 C

ATOM 5335 NE2 HIS A 359 58.883 27.896 51.392 1.00 61.34 N

ATOM 5337 CD2 HIS A 359 57.855 28.510 50.738 1.00 58.13 C

ATOM 5339 C HIS A 359 56.194 32.451 49.042 1.00 52.38 C

ATOM 5340 O HIS A 359 56.192 32.210 47.892 1.00 53.48 O

ATOM 5341 N THR A 360 55.402 33.359 49.534 1.00 50.00 N

ATOM 5343 CA THR A 360 54.434 34.040 48.722 1.00 48.70 C

ATOM 5345 CB THR A 360 53.195 33.835 49.430 1.00 45.16 C

ATOM 5347 OGl THR A 360 52.938 32.444 49.359 1.00 46.70 O

ATOM 5349 CG2 THR A 360 52.036 34.453 48.731 1.00 44.91 C

ATOM 5353 C THR A 360 54.786 35.512 48.561 1.00 48.92 C

ATOM 5354 O THR A 360 54.978 36.188 49.533 1.00 48.33 O

ATOM 5355 N PRO A 361 55.010 35.986 47.351 1.00 50.79 N

ATOM 5356 CA PRO A 361 55.426 37.375 47.190 1.00 51.83 C

ATOM 5358 CB PRO A 361 55.759 37.484 45.706 1.00 54.65 C

ATOM 5361 CG PRO A 361 55.333 36.260 45.089 1.00 54.61 C

ATOM 5364 CD PRO A 361 55.017 35.248 46.088 1.00 52.35 C

ATOM 5367 C PRO A 361 54.285 38.263 47.500 1.00 48.71 C

ATOM 5368 O PRO A 361 53.182 37.783 47.427 1.00 47.40 O

ATOM 5369 N PRO A 362 54.507 39.526 47.794 1.00 48.27 N

ATOM 5370 CA PRO A 362 53.421 40.468 47.950 1.00 46.05 C

ATOM 5372 CB PRO A 362 54.162 41.791 48.029 1.00 47.43 C ATOM 5375 CG PRO A 362 55.417 41.523 47.789 1.00 49.64 C

ATOM 5378 CD PRO A 362 55.780 40.167 48.028 1.00 50.35 C

ATOM 5381 C PRO A 362 52.473 40.437 46.765 1.00 45.74 C

ATOM 5382 O PRO A 362 52.943 40.284 45.696 1.00 49.40 O

ATOM 5383 N LEU A 363 51.189 40.595 46.966 1.00 44.33 N

ATOM 5385 CA LEU A 363 50.174 40.533 45.920 1.00 44.66 C

ATOM 5387 CB LEU A 363 48.831 40.112 46.510 1.00 41.08 C

ATOM 5390 CG LEU A 363 47.517 40.078 45.722 1.00 40.32 C

ATOM 5392 CDl LEU A 363 47.505 39.026 44.654 1.00 41.76 C

ATOM 5396 CD2 LEU A 363 46.293 39.759 46.643 1.00 37.90 C

ATOM 5400 C LEU A 363 49.957 41.904 45.321 1.00 46.91 C

ATOM 5401 O LEU A 363 49.602 42.858 46.011 1.00 46.28 O

ATOM 5402 N ASP A 364 50.142 41.990 44.006 1.00 50.07 N

ATOM 5404 CA ASP A 364 49.742 43.191 43.278 1.00 50.91 C

ATOM 5406 CB ASP A 364 50.197 43.079 41.819 1.00 54.23 C

ATOM 5409 CG ASP A 364 49.881 44.322 40.987 1.00 56.02 C

ATOM 5410 ODl ASP A 364 49.213 45.282 41.502 1.00 50.42 O

ATOM 5411 OD2 ASP A 364 50.278 44.378 39.776 1.00 60.00 O

ATOM 5412 C ASP A 364 48.221 43.399 43.404 1.00 47.27 C

ATOM 5413 O ASP A 364 47.433 42.672 42.883 1.00 45.88 O

ATOM 5414 N PRO A 365 47.821 44.436 44.058 1.00 46.25 N

ATOM 5415 CA PRO A 365 46.404 44.751 44.166 1.00 45.25 C

ATOM 5417 CB PRO A 365 46.408 46.030 44.972 1.00 45.77 C

ATOM 5420 CG PRO A 365 47.706 45.971 45.683 1.00 46.71 C

ATOM 5423 CD PRO A 365 48.660 45.428 44.709 1.00 47.17 C

ATOM 5426 C PRO A 365 45.610 45.003 42.889 1.00 47.18 C

ATOM 5427 O PRO A 365 44.431 44.806 43.003 1.00 46.77 O

ATOM 5428 N GLN A 366 46.155 45.502 41.778 1.00 50.90 N

ATOM 5430 CA GLN A 366 45.415 45.498 40.507 1.00 52.74 C

ATOM 5432 CB GLN A 366 46.289 45.759 39.264 1.00 56.32 C

ATOM 5439 C GLN A 366 44.779 44.131 40.329 1.00 51.62 C

ATOM 5440 O GLN A 366 43.737 44.006 39.686 1.00 53.12 O

ATOM 5441 N GLU A 367 45.392 43.090 40.873 1.00 49.93 N

ATOM 5443 CA GLU A 367 44.957 41.743 40.530 1.00 49.07 C

ATOM 5445 CB GLU A 367 46.016 40.748 40.955 1.00 49.47 C

ATOM 5448 CG GLU A 367 47.254 40.827 40.170 1.00 55.32 C

ATOM 5451 CD GLU A 367 47.521 39.537 39.415 1.00 65.30 C

ATOM 5452 OEl GLU A 367 47.045 39.472 38.236 1.00 71.91 O

ATOM 5453 OE2 GLU A 367 48.219 38.601 39.984 1.00 69.48 O

ATOM 5454 C GLU A 367 43.609 41.341 41.121 1.00 44.37 C

ATOM 5455 O GLU A 367 43.026 40.320 40.783 1.00 43.44 O

ATOM 5456 N LEU A 368 43.146 42.122 42.045 1.00 41.59 N

ATOM 5458 CA LEU A 368 41.862 41.872 42.622 1.00 39.34 C

ATOM 5460 CB LEU A 368 41.649 42.755 43.821 1.00 37.40 C

ATOM 5463 CG LEU A 368 42.571 42.306 44.922 1.00 37.05 C

ATOM 5465 CDl LEU A 368 42.591 43.311 46.006 1.00 37.85 C

ATOM 5469 CD2 LEU A 368 42.136 40.982 45.456 1.00 37.21 C

ATOM 5473 C LEU A 368 40.775 42.088 41.612 1.00 40.58 C

ATOM 5474 O LEU A 368 39.749 41.513 41.759 1.00 39.88 O

ATOM 5475 N ASP A 369 41.013 42.861 40.558 1.00 44.30 N

ATOM 5477 CA ASP A 369 40.101 42.958 39.417 1.00 46.16 C

ATOM 5479 CB ASP A 369 40.752 43.678 38.251 1.00 50.23 C

ATOM 5482 CG ASP A 369 41.010 45.227 38.506 1.00 55.84 C

ATOM 5483 ODl ASP A 369 40.507 45.849 39.505 1.00 57.91 O

ATOM 5484 OD2 ASP A 369 41.782 45.893 37.753 1.00 60.79 O

ATOM 5485 C ASP A 369 39.621 41.612 38.939 1.00 45.71 C

ATOM 5486 O ASP A 369 38.531 41.537 38.475 1.00 46.84 O

ATOM 5487 N ILE A 370 40.412 40.553 39.067 1.00 45.58 N

ATOM 5489 CA ILE A 370 40.011 39.148 38.769 1.00 46.13 C

ATOM 5491 CB ILE A 370 41.135 38.210 39.219 1.00 46.46 C

ATOM 5493 CGl ILE A 370 42.075 37.803 38.072 1.00 50.66 C

ATOM 5496 CDl ILE A 370 43.582 37.835 38.532 1.00 51.51 C

ATOM 5500 CG2 ILE A 370 40.622 36.949 39.735 1.00 47.70 C

ATOM 5504 C ILE A 370 38.727 38.626 39.419 1.00 43.97 C

ATOM 5505 O ILE A 370 37.935 37.986 38.824 1.00 45.31 O

ATOM 5506 N LEU A 371 38.532 38.885 40.675 1.00 41.68 N

ATOM 5508 CA LEU A 371 37.290 38.530 41.354 1.00 39.69 C

ATOM 5510 CB LEU A 371 37.476 38.789 42.863 1.00 37.02 C ATOM 5513 CG LEU A 371 38.785 38.136 43.352 1.00 36.34 C

ATOM 5515 CDl LEU A 371 39.215 38.574 44.651 1.00 34.34 C

ATOM 5519 CD2 LEU A 371 38.586 36.658 43.371 1.00 38.01 C

ATOM 5523 C LEU A 371 36.031 39.257 40.875 1.00 40.31 C

ATOM 5524 O LEU A 371 34.962 38.940 41.363 1.00 38.85 O

ATOM 5525 N LYS A 372 36.131 40.222 39.959 1.00 42.21 N

ATOM 5527 CA LYS A 372 34.932 40.898 39.422 1.00 43.84 C

ATOM 5529 CB LYS A 372 35.285 41.942 38.377 1.00 46.36 C

ATOM 5532 CG LYS A 372 35.513 43.305 38.954 1.00 47.88 C

ATOM 5535 CD LYS A 372 36.436 44.155 38.058 1.00 51.39 C

ATOM 5538 CE LYS A 372 36.918 45.449 38.779 1.00 53.07 C

ATOM 5541 NZ LYS A 372 38.090 46.150 38.045 1.00 59.80 N

ATOM 5545 C LYS A 372 33.950 39.980 38.766 1.00 44.83 C

ATOM 5546 O LYS A 372 32.860 40.345 38.495 1.00 45.62 O

ATOM 5547 N THR A 373 34.355 38.775 38.458 1.00 46.35 N

ATOM 5549 CA THR A 373 33.487 37.815 37.799 1.00 47.94 C

ATOM 5551 CB THR A 373 34.382 36.802 37.192 1.00 48.66 C

ATOM 5553 OGl THR A 373 35.052 37.419 36.130 1.00 51.06 O

ATOM 5555 CG2 THR A 373 33.564 35.865 36.391 1.00 55.55 C

ATOM 5559 C THR A 373 32.508 37.084 38.700 1.00 45.96 C

ATOM 5560 O THR A 373 31.617 36.372 38.216 1.00 48.41 O

ATOM 5561 N VAL A 374 32.706 37.253 39.998 1.00 42.63 N

ATOM 5563 CA VAL A 374 32.140 36.424 41.020 1.00 40.86 C

ATOM 5565 CB VAL A 374 33.088 36.339 42.283 1.00 38.33 C

ATOM 5567 CGl VAL A 374 32.534 35.381 43.293 1.00 37.92 C

ATOM 5571 CG2 VAL A 374 34.458 35.804 41.921 1.00 38.98 C

ATOM 5575 C VAL A 374 30.751 36.893 41.416 1.00 40.06 C

ATOM 5576 O VAL A 374 30.539 38.005 41.826 1.00 39.99 O

ATOM 5577 N LYS A 375 29.823 35.983 41.353 1.00 40.81 N

ATOM 5579 CA LYS A 375 28.452 36.273 41.649 1.00 42.35 C

ATOM 5581 CB LYS A 375 27.541 35.795 40.477 1.00 46.59 C

ATOM 5584 CG LYS A 375 27.777 36.549 39.090 1.00 50.24 C

ATOM 5587 CD LYS A 375 26.669 36.227 38.059 1.00 57.80 C

ATOM 5590 CE LYS A 375 27.128 36.178 36.545 1.00 62.46 C

ATOM 5593 NZ LYS A 375 26.016 36.062 35.526 1.00 61.68 N

ATOM 5597 C LYS A 375 28.008 35.654 42.952 1.00 40.06 C

ATOM 5598 O LYS A 375 27.173 36.205 43.624 1.00 39.08 O

ATOM 5599 N GLU A 376 28.528 34.503 43.309 1.00 39.23 N

ATOM 5601 CA GLU A 376 28.081 33.914 44.552 1.00 39.53 C

ATOM 5603 CB GLU A 376 26.947 32.867 44.334 1.00 41.78 C

ATOM 5606 CG GLU A 376 27.373 31.519 43.819 1.00 44.47 C

ATOM 5609 CD GLU A 376 26.253 30.494 43.764 1.00 47.77 C

ATOM 5610 OEl GLU A 376 25.436 30.495 44.646 1.00 51.29 O

ATOM 5611 OE2 GLU A 376 26.180 29.681 42.851 1.00 49.03 O

ATOM 5612 C GLU A 376 29.214 33.326 45.341 1.00 37.53 C

ATOM 5613 O GLU A 376 30.135 32.819 44.752 1.00 38.28 O

ATOM 5614 N LEU A 377 29.159 33.465 46.662 1.00 35.71 N

ATOM 5616 CA LEU A 377 29.980 32.695 47.555 1.00 35.03 C

ATOM 5618 CB LEU A 377 30.888 33.582 48.445 1.00 32.95 C

ATOM 5621 CG LEU A 377 31.383 34.875 Al.122 1.00 32.32 C

ATOM 5623 CDl LEU A 377 32.373 35.705 48.488 1.00 30.13 C

ATOM 5627 CD2 LEU A 377 32.034 34.537 46.491 1.00 36.27 C

ATOM 5631 C LEU A 377 29.001 31.854 48.361 1.00 36.88 C

ATOM 5632 O LEU A 377 28.064 32.351 48.983 1.00 37.14 O

ATOM 5633 N THR A 378 29.199 30.548 48.278 1.00 38.82 N

ATOM 5635 CA THR A 378 28.558 29.513 49.108 1.00 39.57 C

ATOM 5637 CB THR A 378 29.221 28.290 48.593 1.00 41.13 C

ATOM 5639 OGl THR A 378 28.353 27.866 47.593 1.00 41.94 O

ATOM 5641 CG2 THR A 378 29.395 27.056 49.550 1.00 44.08 C

ATOM 5645 C THR A 378 28.753 29.721 50.604 1.00 37.78 C

ATOM 5646 O THR A 378 27.843 29.535 51.415 1.00 36.72 O

ATOM 5647 N GLY A 379 29.962 30.195 50.908 1.00 36.56 N

ATOM 5649 CA GLY A 379 30.487 30.357 52.264 1.00 35.72 C

ATOM 5652 C GLY A 379 30.468 31.774 52.761 1.00 33.26 C

ATOM 5653 O GLY A 379 29.453 32.421 52.744 1.00 34.48 O

ATOM 5654 N PHE A 380 31.604 32.269 53.181 1.00 31.43 N

ATOM 5656 CA PHE A 380 31.641 33.606 53.748 1.00 30.14 C

ATOM 5658 CB PHE A 380 31.949 33.563 55.237 1.00 29.78 C ATOM 5661 CG PHE A 380 33.326 33.040 55.606 1.00 28.19 C

ATOM 5662 CDl PHE A 380 34.468 33.856 55.512 1.00 26.22 C

ATOM 5664 CEl PHE A 380 35.680 33.405 55.974 1.00 25.15 C

ATOM 5666 CZ PHE A 380 35.755 32.140 56.510 1.00 26.34 C

ATOM 5668 CE2 PHE A 380 34.631 31.325 56.573 1.00 27.52 C

ATOM 5670 CD2 PHE A 380 33.459 31.771 56.148 1.00 27.63 C

ATOM 5672 C PHE A 380 32.649 34.455 53.086 1.00 28.80 C

ATOM 5673 O PHE A 380 33.535 33.928 52.414 1.00 30.25 O

ATOM 5674 N LEU A 381 32.580 35.737 53.345 1.00 26.76 N

ATOM 5676 CA LEU A 381 33.462 36.629 52.687 1.00 27.56 C

ATOM 5678 CB LEU A 381 32.671 37.545 51.773 1.00 27.59 C

ATOM 5681 CG LEU A 381 33.418 38.759 51.282 1.00 28.54 C

ATOM 5683 CDl LEU A 381 34.748 38.298 50.721 1.00 30.46 C

ATOM 5687 CD2 LEU A 381 32.616 39.439 50.209 1.00 32.21 C

ATOM 5691 C LEU A 381 34.189 37.411 53.743 1.00 27.21 C

ATOM 5692 O LEU A 381 33.594 38.246 54.431 1.00 28.39 O

ATOM 5693 N LEU A 382 35.471 37.202 53.868 1.00 26.93 N

ATOM 5695 CA LEU A 382 36.188 37.838 54.953 1.00 27.83 C

ATOM 5697 CB LEU A 382 36.849 36.750 55.764 1.00 28.01 C

ATOM 5700 CG LEU A 382 37.909 37.206 56.753 1.00 29.87 C

ATOM 5702 CDl LEU A 382 37.249 38.057 57.829 1.00 31.23 C

ATOM 5706 CD2 LEU A 382 38.571 36.020 57.423 1.00 29.60 C

ATOM 5710 C LEU A 382 37.239 38.826 54.424 1.00 27.94 C

ATOM 5711 O LEU A 382 38.189 38.425 53.770 1.00 28.55 O

ATOM 5712 N ILE A 383 37.106 40.104 54.738 1.00 28.44 N

ATOM 5714 CA ILE A 383 37.992 41.136 54.168 1.00 29.01 C

ATOM 5716 CB ILE A 383 37.182 42.076 53.298 1.00 30.11 C

ATOM 5718 CGl ILE A 383 36.362 41.266 52.311 1.00 31.00 C

ATOM 5721 CDl ILE A 383 35.938 42.136 51.127 1.00 32.70 C

ATOM 5725 CG2 ILE A 383 38.119 43.072 52.508 1.00 29.84 C

ATOM 5729 C ILE A 383 38.695 41.952 55.210 1.00 28.25 C

ATOM 5730 O ILE A 383 38.130 42.865 55.743 1.00 27.90 O

ATOM 5731 N GLN A 384 39.944 41.635 55.486 1.00 28.72 N

ATOM 5733 CA GLN A 384 40.640 42.232 56.611 1.00 28.78 C

ATOM 5735 CB GLN A 384 41.213 41.148 57.429 1.00 28.34 C

ATOM 5738 CG GLN A 384 40.192 40.473 58.315 1.00 27.69 C

ATOM 5741 CD GLN A 384 40.787 39.489 59.310 1.00 25.79 C

ATOM 5742 OEl GLN A 384 41.947 39.167 59.277 1.00 29.42 O

ATOM 5743 NE2 GLN A 384 39.997 39.070 60.220 1.00 29.85 N

ATOM 5746 C GLN A 384 41.735 43.122 56.073 1.00 30.69 C

ATOM 5747 O GLN A 384 42.402 43.817 56.826 1.00 33.98 O

ATOM 5748 N ALA A 385 41.892 43.164 54.756 1.00 30.13 N

ATOM 5750 CA ALA A 385 42.856 44.036 54.126 1.00 30.49 C

ATOM 5752 CB ALA A 385 44.242 43.332 54.044 1.00 30.62 C

ATOM 5756 C ALA A 385 42.348 44.372 52.728 1.00 31.09 C

ATOM 5757 O ALA A 385 41.586 43.598 52.083 1.00 30.22 O

ATOM 5758 N TRP A 386 42.808 45.504 52.232 1.00 32.17 N

ATOM 5760 CA TRP A 386 42.343 45.986 50.991 1.00 33.08 C

ATOM 5762 CB TRP A 386 40.903 46.412 51.231 1.00 32.74 C

ATOM 5765 CG TRP A 386 40.173 46.579 50.012 1.00 36.40 C

ATOM 5766 CDl TRP A 386 39.885 47.756 49.354 1.00 40.08 C

ATOM 5768 NEl TRP A 386 39.158 47.478 48.227 1.00 40.21 N

ATOM 5770 CE2 TRP A 386 39.049 46.114 48.114 1.00 40.12 C

ATOM 5771 CD2 TRP A 386 39.676 45.539 49.213 1.00 35.62 C

ATOM 5772 CE3 TRP A 386 39.657 44.174 49.339 1.00 34.88 C

ATOM 5774 CZ3 TRP A 386 39.049 43.446 48.400 1.00 37.08 C

ATOM 5776 CH2 TRP A 386 38.429 44.025 47.329 1.00 39.08 C

ATOM 5778 CZ2 TRP A 386 38.425 45.359 47.159 1.00 42.51 C

ATOM 5780 C TRP A 386 43.127 47.177 50.563 1.00 34.61 C

ATOM 5781 O TRP A 386 43.390 48.039 51.341 1.00 37.82 O

ATOM 5782 N PRO A 387 43.434 47.332 49.320 1.00 36.03 N

ATOM 5783 CA PRO A 387 44.281 48.435 48.949 1.00 38.07 C

ATOM 5785 CB PRO A 387 44.323 48.312 47.443 1.00 39.84 C

ATOM 5788 CG PRO A 387 43.252 47.516 47.081 1.00 38.50 C

ATOM 5791 CD PRO A 387 42.989 46.569 48.156 1.00 36.66 C

ATOM 5794 C PRO A 387 43.736 49.784 49.409 1.00 39.23 C

ATOM 5795 O PRO A 387 42.603 50.184 49.169 1.00 39.83 O

ATOM 5796 N GLU A 388 44.573 50.483 50.137 1.00 41.44 N ATOM 5798 CA GLU A 388 44.233 51.765 50.763 1.00 43.29 C

ATOM 5800 CB GLU A 388 45.383 52.255 51.622 1.00 45.21 C

ATOM 5803 CG GLU A 388 45.567 51.443 52.897 1.00 45.28 C

ATOM 5806 CD GLU A 388 46.796 51.891 53.654 1.00 52.65 C

ATOM 5807 OEl GLU A 388 47.893 51.297 53.459 1.00 53.52 O

ATOM 5808 OE2 GLU A 388 46.653 52.891 54.420 1.00 57.96 O

ATOM 5809 C GLU A 388 43.796 52.887 49.862 1.00 45.35 C

ATOM 5810 O GLU A 388 43.063 53.764 50.284 1.00 45.89 O

ATOM 5811 N ASN A 389 44.170 52.836 48.609 1.00 47.38 N

ATOM 5813 CA ASN A 389 43.678 53.842 47.663 1.00 50.51 C

ATOM 5815 CB ASN A 389 44.805 54.240 46.668 1.00 54.16 C

ATOM 5818 CG ASN A 389 45.254 53.045 45.796 1.00 56.14 C

ATOM 5819 ODl ASN A 389 45.805 52.052 46.328 1.00 62.07 O

ATOM 5820 ND2 ASN A 389 44.886 53.055 44.521 1.00 57.83 N

ATOM 5823 C ASN A 389 42.455 53.391 46.860 1.00 49.44 C

ATOM 5824 O ASN A 389 42.303 53.859 45.756 1.00 52.95 O

ATOM 5825 N ARG A 390 41.611 52.494 47.344 1.00 46.09 N

ATOM 5827 CA ARG A 390 40.371 52.217 46.649 1.00 46.76 C

ATOM 5829 CB ARG A 390 40.234 50.742 46.244 1.00 45.10 C

ATOM 5832 CG ARG A 390 41.217 50.172 45.285 1.00 47.34 C

ATOM 5835 CD ARG A 390 41.438 50.956 43.977 1.00 53.54 C

ATOM 5838 NE ARG A 390 40.695 50.412 42.824 1.00 53.39 N

ATOM 5840 CZ ARG A 390 39.518 50.880 42.393 1.00 54.47 C

ATOM 5841 NHl ARG A 390 38.862 51.878 43.014 1.00 59.31 N

ATOM 5844 NH2 ARG A 390 38.951 50.325 41.362 1.00 52.63 N

ATOM 5847 C ARG A 390 39.172 52.536 47.545 1.00 46.14 C

ATOM 5848 O ARG A 390 38.999 51.940 48.589 1.00 44.17 O

ATOM 5849 N THR A 391 38.283 53.411 47.114 1.00 48.34 N

ATOM 5851 CA THR A 391 37.246 53.899 48.039 1.00 47.56 C

ATOM 5853 CB THR A 391 36.645 55.201 47.543 1.00 50.22 C

ATOM 5855 OGl THR A 391 35.870 54.878 46.403 1.00 51.02 O

ATOM 5857 CG2 THR A 391 37.689 56.203 47.035 1.00 51.77 C

ATOM 5861 C THR A 391 36.102 52.893 48.239 1.00 45.74 C

ATOM 5862 O THR A 391 35.269 53.087 49.121 1.00 45.03 O

ATOM 5863 N ASP A 392 36.052 51.812 47.467 1.00 44.71 N

ATOM 5865 CA ASP A 392 35.129 50.743 47.833 1.00 42.13 C

ATOM 5867 CB ASP A 392 33.840 50.977 47.144 1.00 43.91 C

ATOM 5870 CG ASP A 392 33.994 51.000 45.722 1.00 45.23 C

ATOM 5871 ODl ASP A 392 35.000 50.496 45.229 1.00 45.27 O

ATOM 5872 OD2 ASP A 392 33.161 51.519 45.017 1.00 46.76 O

ATOM 5873 C ASP A 392 35.663 49.385 47.506 1.00 40.51 C

ATOM 5874 O ASP A 392 36.837 49.268 47.180 1.00 42.21 O

ATOM 5875 N LEU A 393 34.839 48.351 47.691 1.00 39.13 N

ATOM 5877 CA LEU A 393 35.208 46.964 47.389 1.00 37.38 C

ATOM 5879 CB LEU A 393 34.402 45.992 48.238 1.00 35.46 C

ATOM 5882 CG LEU A 393 34.425 46.226 49.733 1.00 34.54 C

ATOM 5884 CDl LEU A 393 33.565 45.205 50.454 1.00 34.20 C

ATOM 5888 CD2 LEU A 393 35.810 46.075 50.173 1.00 34.63 C

ATOM 5892 C LEU A 393 34.967 46.666 45.901 1.00 38.22 C

ATOM 5893 O LEU A 393 34.103 45.865 45.572 1.00 38.13 O

ATOM 5894 N HIS A 394 35.752 47.300 45.025 1.00 38.65 N

ATOM 5896 CA HIS A 394 35.460 47.287 43.607 1.00 40.24 C

ATOM 5898 CB HIS A 394 36.506 48.073 42.878 1.00 41.20 C

ATOM 5901 CG HIS A 394 37.873 47.539 43.061 1.00 43.28 C

ATOM 5902 NDl HIS A 394 38.577 47.684 44.242 1.00 44.16 N

ATOM 5904 CEl HIS A 394 39.754 47.091 44.108 1.00 44.04 C

ATOM 5906 NE2 HIS A 394 39.820 46.535 42.906 1.00 44.28 N

ATOM 5908 CD2 HIS A 394 38.649 46.787 42.240 1.00 44.56 C

ATOM 5910 C HIS A 394 35.397 45.864 43.053 1.00 39.79 C

ATOM 5911 O HIS A 394 34.658 45.565 42.118 1.00 39.77 O

ATOM 5912 N ALA A 395 36.186 44.971 43.639 1.00 38.62 N

ATOM 5914 CA ALA A 395 36.342 43.675 43.038 1.00 38.76 C

ATOM 5916 CB ALA A 395 37.493 43.036 43.581 1.00 37.86 C

ATOM 5920 C ALA A 395 35.102 42.811 43.228 1.00 38.35 C

ATOM 5921 O ALA A 395 34.964 41.819 42.513 1.00 39.40 O

ATOM 5922 N PHE A 396 34.194 43.239 44.111 1.00 36.67 N

ATOM 5924 CA PHE A 396 32.986 42.520 44.416 1.00 36.80 C

ATOM 5926 CB PHE A 396 32.934 42.244 45.922 1.00 35.11 C ATOM 5929 CG PHE A 396 34.060 41.284 46.399 1.00 34.66 C

ATOM 5930 CDl PHE A 396 35.141 41.734 47.116 1.00 31.86 C

ATOM 5932 CEl PHE A 396 36.149 40.871 47.508 1.00 30.93 C

ATOM 5934 CZ PHE A 396 36.112 39.574 47.201 1.00 31.65 C

ATOM 5936 CE2 PHE A 396 35.056 39.084 46.528 1.00 33.87 C

ATOM 5938 CD2 PHE A 396 34.020 39.942 46.097 1.00 34.52 C

ATOM 5940 C PHE A 396 31.709 43.215 43.939 1.00 38.98 C

ATOM 5941 O PHE A 396 30.598 42.884 44.347 1.00 40.05 O

ATOM 5942 N GLU A 397 31.828 44.157 43.030 1.00 41.06 N

ATOM 5944 CA GLO A 397 30.664 44.849 42.495 1.00 43.09 C

ATOM 5946 CB GLϋ A 397 31.192 45.871 41.507 1.00 45.95 C

ATOM 5949 CG GLU A 397 31.738 45.211 40.255 1.00 49.91 C

ATOM 5952 CD GLU A 397 32.326 46.179 39.236 1.00 58.00 C

ATOM 5953 OEl GLU A 397 31.536 46.971 38.642 1.00 63.84 O

ATOM 5954 OE2 GLU A 397 33.574 46.098 38.994 1.00 59.87 O

ATOM 5955 C GLU A 397 29.588 43.961 41.771 1.00 44.36 C

ATOM 5956 O GLU A 397 28.513 44.449 41.344 1.00 45.29 O

ATOM 5957 N ASN A 398 29.882 42.681 41.554 1.00 43.83 N

ATOM 5959 CA ASN A 398 28.902 41.797 40.905 1.00 44.75 C

ATOM 5961 CB ASN A 398 29.486 41.235 39.638 1.00 46.12 C

ATOM 5964 CG ASN A 398 29.691 42.290 38.613 1.00 46.75 C

ATOM 5965 ODl ASN A 398 28.812 43.035 38.309 1.00 50.16 O

ATOM 5966 ND2 ASN A 398 30.866 42.371 38.097 1.00 47.71 N

ATOM 5969 C ASN A 398 28.408 40.673 41.794 1.00 43.09 C

ATOM 5970 O ASN A 398 27.632 39.847 41.387 1.00 44.84 O

ATOM 5971 N LEU A 399 28.830 40.707 43.033 1.00 40.07 N

ATOM 5973 CA LEU A 399 28.488 39.731 43.975 1.00 38.64 C

ATOM 5975 CB LEU A 399 29.387 39.940 45.179 1.00 35.59 C

ATOM 5978 CG LEU A 399 29.067 39.022 46.299 1.00 34.56 C

ATOM 5980 CDl LEU A 399 29.351 37.598 45.883 1.00 36.89 C

ATOM 5984 CD2 LEU A 399 29.858 39.414 47.436 1.00 34.33 C

ATOM 5988 C LEU A 399 27.014 39.935 44.321 1.00 41.17 C

ATOM 5989 O LEU A 399 26.567 40.998 44.836 1.00 42.73 O

ATOM 5990 N GLU A 400 26.261 38.884 44.057 1.00 42.86 N

ATOM 5992 CA GLU A 400 24.817 38.875 44.151 1.00 44.43 C

ATOM 5994 CB GLU A 400 24.277 38.174 42.923 1.00 46.71 C

ATOM 5997 CG GLU A 400 24.484 39.044 41.719 1.00 50.19 C

ATOM 6000 CD GLU A 400 24.161 38.401 40.366 1.00 56.20 C

ATOM 6001 OEl GLU A 400 23.095 37.786 40.242 1.00 56.23 O

ATOM 6002 OE2 GLU A 400 24.980 38.579 39.408 1.00 58.34 O

ATOM 6003 C GLU A 400 24.316 38.192 45.421 1.00 43.67 C

ATOM 6004 O GLU A 400 23.233 38.518 45.885 1.00 44.99 O

ATOM 6005 N ILE A 401 25.130 37.306 46.011 1.00 41.83 N

ATOM 6007 CA ILE A 401 24.737 36.490 47.162 1.00 40.84 C

ATOM 6009 CB ILE A 401 23.734 35.422 46.710 1.00 42.90 C

ATOM 6011 CGl ILE A 401 23.449 34.429 47.814 1.00 43.25 C

ATOM 6014 CDl ILE A 401 22.256 33.586 47.448 1.00 45.27 C

ATOM 6018 CG2 ILE A 401 24.253 34.643 45.619 1.00 44.73 C

ATOM 6022 C ILE A 401 25.897 35.831 47.895 1.00 38.33 C

ATOM 6023 O ILE A 401 26.794 35.247 47.303 1.00 37.78 O

ATOM 6024 N ILE A 402 25.857 35.927 49.206 1.00 37.64 N

ATOM 6026 CA ILE A 402 26.758 35.219 50.099 1.00 35.89 C

ATOM 6028 CB ILE A 402 27.313 36.190 51.117 1.00 33.76 C

ATOM 6030 CGl ILE A 402 28.327 37.122 50.428 1.00 33.45 C

ATOM 6033 CDl ILE A 402 28.729 38.356 51.238 1.00 30.73 C

ATOM 6037 CG2 ILE A 402 27.959 35.445 52.248 1.00 33.22 C

ATOM 6041 C ILE A 402 25.872 34.221 50.789 1.00 38.27 C

ATOM 6042 O ILE A 402 25.042 34.590 51.611 1.00 40.21 O

ATOM 6043 N ARG A 403 25.961 32.954 50.440 1.00 39.72 N

ATOM 6045 CA ARG A 403 25.029 31.971 51.036 1.00 41.41 C

ATOM 6047 CB ARG A 403 25.094 30.665 50.280 1.00 42.06 C

ATOM 6050 CG ARG A 403 24.566 30.759 48.913 1.00 42.50 C

ATOM 6053 CD ARG A 403 24.271 29.361 48.306 1.00 45.57 C

ATOM 6056 NE ARG A 403 23.861 29.447 46.910 1.00 46.93 N

ATOM 6058 CZ ARG A 403 22.741 30.008 46.512 1.00 49.93 C

ATOM 6059 NHl ARG A 403 21.876 30.503 47.387 1.00 52.29 N

ATOM 6062 NH2 ARG A 403 22.461 30.068 45.235 1.00 52.68 N

ATOM 6065 C ARG A 403 25.272 31.712 52.541 1.00 40.44 C ATOM 6066 O ARG A 403 24.332 31.432 53.262 1.00 41.87 O

ATOM 6067 N GLY A 404 26.520 31.772 52.979 1.00 38.47 N

ATOM 6069 CA GLY A 404 26.841 31.694 54.394 1.00 38.72 C

ATOM 6072 C GLY A 404 26.779 30.296 55.021 1.00 40.86 C

ATOM 6073 O GLY A 404 26.528 30.097 56.219 1.00 42.25 O

ATOM 6074 N ARG A 405 26.982 29.284 54.204 1.00 41.64 N

ATOM 6076 CA ARG A 405 26.955 27.903 54.687 1.00 43.01 C

ATOM 6078 CB ARG A 405 27.068 27.061 53.455 1.00 44.80 C

ATOM 6081 CG ARG A 405 25.790 26.999 52.727 1.00 46.83 C

ATOM 6084 CD ARG A 405 25.923 26.159 51.460 1.00 49.83 C

ATOM 6087 NE ARG A 405 24.656 26.202 50.690 1.00 54.46 N

ATOM 6089 CZ ARG A 405 24.534 25.597 49.539 1.00 55.52 C

ATOM 6090 NHl ARG A 405 25.589 24.930 49.073 1.00 55.71 N

ATOM 6093 NH2 ARG A 405 23.379 25.608 48.890 1.00 59.28 N

ATOM 6096 C ARG A 405 28.043 27.497 55.659 1.00 40.66 C

ATOM 6097 O ARG A 405 27.881 26.744 56.531 1.00 41.11 O

ATOM 6098 N THR A 406 29.194 27.962 55.351 1.00 40.05 N

ATOM 6100 CA THR A 406 30.381 28.035 56.186 1.00 40.02 C

ATOM 6102 CB THR A 406 31.557 27.731 55.244 1.00 39.43 C

ATOM 6104 OGl THR A 406 31.310 26.463 54.715 1.00 43.84 O

ATOM 6106 CG2 THR A 406 32.910 27.424 55.938 1.00 43.39 C

ATOM 6110 C THR A 406 30.393 29.475 56.679 1.00 37.35 C

ATOM 6111 O THR A 406 29.970 30.388 55.965 1.00 36.01 O

ATOM 6112 N LYS A 407 30.744 29.669 57.936 1.00 38.03 N

ATOM 6114 CA LYS A 407 30.913 31.032 58.480 1.00 37.24 C

ATOM 6116 CB LYS A 407 29.808 31.396 59.427 1.00 38.61 C

ATOM 6119 CG LYS A 407 28.408 31.305 58.843 1.00 39.27 C

ATOM 6122 CD LYS A 407 27.467 30.706 59.864 1.00 41.05 C

ATOM 6125 CE LYS A 407 26.150 30.400 59.316 1.00 44.32 C

ATOM 6128 NZ LYS A 407 25.229 31.288 60.019 1.00 52.24 N

ATOM 6132 C LYS A 407 32.218 31.114 59.237 1.00 37.24 C

ATOM 6133 O LYS A 407 32.849 30.135 59.489 1.00 40.60 O

ATOM 6134 N GLN A 408 32.674 32.299 59.552 1.00 36.38 N

ATOM 6136 CA GLN A 408 33.979 32.465 60.158 1.00 34.55 C

ATOM 6138 CB GLN A 408 34.581 33.801 59.825 1.00 32.09 C

ATOM 6141 CG GLN A 408 35.948 33.899 60.498 1.00 31.64 C

ATOM 6144 CD GLN A 408 36.473 35.248 60.620 1.00 30.23 C

ATOM 6145 OEl GLN A 408 35.772 36.221 60.467 1.00 39.71 O

ATOM 6146 NE2 GLN A 408 37.680 35.336 60.852 1.00 26.16 N

ATOM 6149 C GLN A 408 33.734 32.402 61.666 1.00 35.59 C

ATOM 6150 O GLN A 408 32.869 33.106 62.167 1.00 34.95 O

ATOM 6151 N HIS A 409 34.501 31.551 62.338 1.00 35.68 N

ATOM 6153 CA HIS A 409 34.305 31.239 63.709 1.00 36.96 C

ATOM 6155 CB HIS A 409 34.594 32.495 64.525 1.00 36.30 C

ATOM 6158 CG HIS A 409 35.974 32.999 64.388 1.00 32.03 C

ATOM 6159 NDl HIS A 409 37.046 32.335 64.885 1.00 36.03 N

ATOM 6161 CEl HIS A 409 38.149 32.995 64.602 1.00 32.96 C

ATOM 6163 NE2 HIS A 409 37.823 34.099 63.993 1.00 29.44 N

ATOM 6165 CD2 HIS A 409 36.464 34.108 63.819 1.00 33.90 C

ATOM 6167 C HIS A 409 32.898 30.688 63.922 1.00 38.45 C

ATOM 6168 O HIS A 409 32.282 30.785 64.967 1.00 39.82 O

ATOM 6169 N GLY A 410 32.341 30.135 62.879 1.00 39.18 N

ATOM 6171 CA GLY A 410 30.948 29.727 62.974 1.00 40.64 C

ATOM 6174 C GLY A 410 30.003 30.872 63.123 1.00 39.89 C

ATOM 6175 O GLY A 410 28.908 30.596 63.288 1.00 40.91 O

ATOM 6176 N ASN A 411 30.443 32.129 63.096 1.00 39.05 N

ATOM 6178 CA ASN A 411 29.582 33.303 63.276 1.00 39.30 C

ATOM 6180 CB ASN A 411 30.176 34.429 64.213 1.00 39.22 C

ATOM 6183 CG ASN A 411 30.202 34.049 65.693 1.00 44.51 C

ATOM 6184 ODl ASN A 411 29.929 32.909 65.994 1.00 52.63 O

ATOM 6185 ND2 ASN A 411 30.548 34.986 66.614 1.00 41.99 N

ATOM 6188 C ASN A 411 29.312 33.940 61.907 1.00 37.22 C

ATOM 6189 O ASN A 411 28.194 33.948 61.435 1.00 37.23 O

ATOM 6190 N PHE A 412 30.342 34.474 61.278 1.00 34.68 N

ATOM 6192 CA PHE A 412 30.135 35.478 60.287 1.00 33.77 C

ATOM 6194 CB PHE A 412 31.294 36.438 60.393 1.00 32.92 C

ATOM 6197 CG PHE A 412 31.440 37.028 61.750 1.00 33.90 C

ATOM 6198 CDl PHE A 412 32.607 36.831 62.507 1.00 34.35 C ATOM 6200 CEl PHE A 412 32.708 37.353 63.793 1.00 31.85 C

ATOM 6202 CZ PHE A 412 31.688 38.084 64.275 1.00 33.72 C

ATOM 6204 CE2 PHE A 412 30.575 38.290 63.552 1.00 33.28 C

ATOM 6206 CD2 PHE A 412 30.419 37.748 62.306 1.00 32.58 C

ATOM 6208 C PHE A 412 30.053 34.983 58.856 1.00 33.95 C

ATOM 6209 O PHE A 412 30.865 34.164 58.410 1.00 34.69 O

ATOM 6210 N SER A 413 29.101 35.512 58.088 1.00 34.35 N

ATOM 6212 CA SER A 413 29.154 35.319 56.617 1.00 33.33 C

ATOM 6214 CB SER A 413 27.803 34.919 56.082 1.00 34.29 C

ATOM 6217 OG SER A 413 26.927 35.986 56.195 1.00 34.47 O

ATOM 6219 C SER A 413 29.711 36.474 55.800 1.00 31.62 C

ATOM 6220 O SER A 413 29.980 36.268 54.679 1.00 30.19 O

ATOM 6221 N LEO A 414 29.810 37.698 56.361 1.00 32.41 N

ATOM 6223 CA LEO A 414 30.474 38.882 55.716 1.00 31.11 C

ATOM 6225 CB LEU A 414 29.458 39.830 55.119 1.00 32.13 C

ATOM 6228 CG LEU A 414 29.895 41.226 54.590 1.00 33.57 C

ATOM 6230 CDl LEU A 414 31.044 41.176 53.529 1.00 33.54 C

ATOM 6234 CD2 LEU A 414 28.737 41.998 53.991 1.00 34.32 C

ATOM 6238 C LEU A 414 31.241 39.660 56.755 1.00 30.16 C

ATOM 6239 O LEU A 414 30.616 40.240 57.603 1.00 31.21 O

ATOM 6240 N ALA A 415 32.565 39.668 56.721 1.00 28.59 N

ATOM 6242 CA ALA A 415 33.347 40.421 57.709 1.00 28.16 C

ATOM 6244 CB ALA A 415 34.171 39.540 58.506 1.00 27.51 C

ATOM 6248 C ALA A 415 34.233 41.399 56.975 1.00 28.12 C

ATOM 6249 O ALA A 415 34.998 41.005 56.099 1.00 28.60 O

ATOM 6250 N VAL A 416 34.077 42.689 57.294 1.00 28.48 N

ATOM 6252 CA VAL A 416 34.865 43.768 56.701 1.00 27.99 C

ATOM 6254 CB VAL A 416 33.940 44.600 55.867 1.00 28.89 C

ATOM 6256 CGl VAL A 416 34.667 45.745 55.232 1.00 29.37 C

ATOM 6260 CG2 VAL A 416 33.294 43.709 54.828 1.00 29.55 C

ATOM 6264 C VAL A 416 35.492 44.588 57.822 1.00 27.40 C

ATOM 6265 O VAL A 416 34.788 45.252 58.514 1.00 28.63 O

ATOM 6266 N VAL A 417 36.805 44.579 57.982 1.00 26.45 N

ATOM 6268 CA VAL A 417 37.390 45.086 59.181 1.00 27.04 C

ATOM 6270 CB VAL A 417 37.707 43.940 60.175 1.00 27.03 C

ATOM 6272 CGl VAL A 417 38.177 44.508 61.435 1.00 31.02 C

ATOM 6276 CG2 VAL A 417 36.616 43.085 60.494 1.00 25.94 C

ATOM 6280 C VAL A 417 38.700 45.849 58.959 1.00 27.79 C

ATOM 6281 O VAL A 417 39.729 45.304 58.592 1.00 28.44 O

ATOM 6282 N SER A 418 38.659 47.118 59.304 1.00 29.69 N

ATOM 6284 CA SER A 418 39.783 48.037 59.273 1.00 29.96 C

ATOM 6286 CB SER A 418 40.834 47.559 60.216 1.00 30.43 C

ATOM 6289 OG SER A 418 41.770 48.555 60.517 1.00 34.34 O

ATOM 6291 C SER A 418 40.320 48.213 57.889 1.00 30.06 C

ATOM 6292 O SER A 418 41.441 48.007 57.668 1.00 30.27 O

ATOM 6293 N LEU A 419 39.473 48.581 56.934 1.00 30.95 N

ATOM 6295 CA LEU A 419 39.881 49.016 55.578 1.00 30.62 C

ATOM 6297 CB LEU A 419 38.974 48.380 54.560 1.00 29.76 C

ATOM 6300 CG LEU A 419 38.564 46.915 54.692 1.00 27.89 C

ATOM 6302 CDl LEU A 419 37.844 46.349 53.455 1.00 26.37 C

ATOM 6306 CD2 LEU A 419 39.796 46.136 54.942 1.00 30.27 C

ATOM 6310 C LEU A 419 39.787 50.520 55.513 1.00 31.84 C

ATOM 6311 O LEU A 419 39.248 51.129 56.415 1.00 34.04 O

ATOM 6312 N ASN A 420 40.347 51.141 54.505 1.00 32.95 N

ATOM 6314 CA ASN A 420 40.409 52.602 54.421 1.00 35.62 C

ATOM 6316 CB ASN A 420 41.682 53.008 53.739 1.00 37.74 C

ATOM 6319 CG ASN A 420 41.961 54.452 53.815 1.00 40.33 C

ATOM 6320 ODl ASN A 420 41.713 55.072 54.796 1.00 41.29 O

ATOM 6321 ND2 ASN A 420 42.543 54.991 52.774 1.00 42.87 N

ATOM 6324 C ASN A 420 39.322 53.016 53.519 1.00 38.01 C

ATOM 6325 O ASN A 420 39.319 54.112 53.010 1.00 41.16 O

ATOM 6326 N ILE A 421 38.383 52.103 53.301 1.00 37.63 N

ATOM 6328 CA ILE A 421 37.280 52.252 52.393 1.00 38.22 C

ATOM 6330 CB ILE A 421 36.767 50.873 52.179 1.00 36.26 C

ATOM 6332 CGl ILE A 421 36.784 50.662 50.724 1.00 40.93 C

ATOM 6335 CDl ILE A 421 36.644 49.237 50.423 1.00 45.47 C

ATOM 6339 CG2 ILE A 421 35.404 50.467 52.732 1.00 34.04 C

ATOM 6343 C ILE A 421 36.263 53.290 52.797 1.00 40.58 C ATOM 6344 O ILE A 421 36.203 53.706 53.954 1.00 42.88 O

ATOM 6345 N THR A 422 35.511 53.755 51.814 1.00 42.92 N

ATOM 6347 CA THR A 422 34.541 54.868 51.949 1.00 44.98 C

ATOM 6349 CB THR A 422 34.870 55.912 50.914 1.00 47.73 C

ATOM 6351 OGl THR A 422 36.200 56.430 51.181 1.00 49.14 O

ATOM 6353 CG2 THR A 422 33.950 57.054 51.018 1.00 49.95 C

ATOM 6357 C THR A 422 33.106 54.418 51.763 1.00 44.41 C

ATOM 6358 O THR A 422 32.230 54.898 52.433 1.00 46.45 O

ATOM 6359 N SER A 423 32.878 53.462 50.889 1.00 42.64 N

ATOM 6361 CA SER A 423 31.626 52.762 50.831 1.00 41.79 C

ATOM 6363 CB SER A 423 30.874 53.300 49.666 1.00 44.68 C

ATOM 6366 OG SER A 423 31.655 53.146 48.490 1.00 46.25 O

ATOM 6368 C SER A 423 31.838 51.294 50.560 1.00 38.94 C

ATOM 6369 O SER A 423 32.862 50.907 50.044 1.00 37.59 O

ATOM 6370 N LEU A 424 30.846 50.468 50.858 1.00 38.17 N

ATOM 6372 CA LEU A 424 31.038 49.034 50.632 1.00 36.68 C

ATOM 6374 CB LEU A 424 29.949 48.233 51.394 1.00 35.68 C

ATOM 6377 CG LEU A 424 30.177 48.127 52.916 1.00 36.14 C

ATOM 6379 CDl LEU A 424 28.913 47.658 53.776 1.00 34.01 C

ATOM 6383 CD2 LEU A 424 31.441 47.302 53.250 1.00 33.86 C

ATOM 6387 C LEU A 424 31.090 48.724 49.078 1.00 36.95 C

ATOM 6388 O LEU A 424 31.909 48.010 48.555 1.00 33.92 O

ATOM 6389 N GLY A 425 30.182 49.314 48.364 1.00 38.75 N

ATOM 6391 CA GLY A 425 30.155 49.084 46.969 1.00 40.99 C

ATOM 6394 C GLY A 425 29.443 47.814 46.622 1.00 41.20 C

ATOM 6395 O GLY A 425 29.472 47.443 45.460 1.00 44.17 O

ATOM 6396 N LEU A 426 28.805 47.141 47.566 1.00 40.36 N

ATOM 6398 CA LEU A 426 28.240 45.842 47.258 1.00 39.92 C

ATOM 6400 CB LEU A 426 28.082 45.026 48.527 1.00 37.76 C

ATOM 6403 CG LEU A 426 29.426 44.744 49.170 1.00 36.86 C

ATOM 6405 CDl LEU A 426 29.176 43.892 50.403 1.00 38.68 C

ATOM 6409 CD2 LEU A 426 30.381 44.023 48.252 1.00 35.23 C

ATOM 6413 C LEU A 426 26.932 46.001 46.557 1.00 42.18 C

ATOM 6414 O LEU A 426 25.894 45.526 47.046 1.00 44.29 O

ATOM 6415 N ARG A 427 26.948 46.648 45.405 1.00 43.67 N

ATOM 6417 CA ARG A 427 25.710 47.033 44.753 1.00 46.27 C

ATOM 6419 CB ARG A 427 25.952 48.098 43.700 1.00 48.95 C

ATOM 6422 CG ARG A 427 26.781 47.687 42.500 1.00 51.08 C

ATOM 6425 CD ARG A 427 26.942 48.830 41.462 1.00 53.68 C

ATOM 6428 NE ARG A 427 27.600 49.930 42.126 1.00 52.90 N

ATOM 6430 CZ ARG A 427 28.907 49.974 42.333 1.00 54.16 C

ATOM 6431 NHl ARG A 427 29.687 49.026 41.855 1.00 56.67 N

ATOM 6434 NH2 ARG A 427 29.469 50.978 42.973 1.00 53.42 N

ATOM 6437 C ARG A 427 24.921 45.923 44.137 1.00 46.88 C

ATOM 6438 O ARG A 427 23.864 46.167 43.683 1.00 49.33 O

ATOM 6439 N SER A 428 25.423 44.709 44.079 1.00 45.62 N

ATOM 6441 CA SER A 428 24.656 43.644 43.465 1.00 46.68 C

ATOM 6443 CB SER A 428 25.514 42.826 42.506 1.00 45.99 C

ATOM 6446 OG SER A 428 25.834 43.593 41.362 1.00 47.96 O

ATOM 6448 C SER A 428 24.148 42.720 44.486 1.00 45.95 C

ATOM 6449 O SER A 428 23.366 41.806 44.178 1.00 48.53 O

ATOM 6450 N LEU A 429 24.620 42.903 45.703 1.00 44.50 N

ATOM 6452 CA LEU A 429 24.329 41.963 46.753 1.00 43.25 C

ATOM 6454 CB LEU A 429 25.197 42.215 47.923 1.00 40.85 C

ATOM 6457 CG LEU A 429 25.039 41.129 48.966 1.00 40.60 C

ATOM 6459 CDl LEU A 429 25.400 39.734 48.410 1.00 40.92 C

ATOM 6463 CD2 LEU A 429 25.895 41.522 50.121 1.00 38.94 C

ATOM 6467 C LEU A 429 22.889 42.116 47.185 1.00 45.57 C

ATOM 6468 O LEU A 429 22.516 43.074 47.852 1.00 46.09 O

ATOM 6469 N LYS A 430 22.079 41.148 46.801 1.00 46.89 N

ATOM 6471 CA LYS A 430 20.729 41.149 47.203 1.00 49.09 C

ATOM 6473 CB LYS A 430 19.848 40.867 46.020 1.00 52.17 C

ATOM 6476 CG LYS A 430 20.075 41.767 44.775 1.00 56.42 C

ATOM 6479 CD LYS A 430 20.040 43.323 45.059 1.00 58.97 C

ATOM 6482 CE LYS A 430 19.311 44.138 43.898 1.00 64.18 C

ATOM 6485 NZ LYS A 430 18.517 45.353 44.422 1.00 67.30 N

ATOM 6489 C LYS A 430 20.482 40.120 48.287 1.00 48.70 C

ATOM 6490 O LYS A 430 19.396 40.095 48.817 1.00 52.84 O ATOM 6491 N GLU A 431 21.402 39.237 48.636 1.00 45.66 N

ATOM 6493 CA GLU A 431 20.996 38.242 49.591 1.00 44.87 C

ATOM 6495 CB GLU A 431 20.319 37.086 48.889 1.00 46.51 C

ATOM 6498 CG GLU A 431 20.122 35.923 49.821 1.00 47.21 C

ATOM 6501 CD GLU A 431 19.206 34.813 49.314 1.00 54.73 C

ATOM 6502 OEl GLU A 431 18.587 34.845 48.198 1.00 57.66 O

ATOM 6503 OE2 GLU A 431 19.061 33.865 50.108 1.00 58.94 O

ATOM 6504 C GLU A 431 22.172 37.745 50.312 1.00 42.74 C

ATOM 6505 O GLU A 431 23.201 37.454 49.714 1.00 40.52 O

ATOM 6506 N ILE A 432 22.020 37.676 51.635 1.00 43.15 N

ATOM 6508 CA ILE A 432 22.953 36.946 52.541 1.00 40.67 C

ATOM 6510 CB ILE A 432 23.656 37.901 53.551 1.00 38.41 C

ATOM 6512 CGl ILE A 432 24.459 38.988 52.813 1.00 36.41 C

ATOM 6515 CDl ILE A 432 24.835 40.134 53.667 1.00 34.20 C

ATOM 6519 CG2 ILE A 432 24.583 37.096 54.405 1.00 37.20 C

ATOM 6523 C ILE A 432 22.159 35.884 53.298 1.00 42.12 C

ATOM 6524 O ILE A 432 21.589 36.182 54.330 1.00 43.01 O

ATOM 6525 N SER A 433 22.116 34.665 52.767 1.00 43.12 N

ATOM 6527 CA SER A 433 21.267 33.580 53.285 1.00 45.85 C

ATOM 6529 CB SER A 433 21.474 32.275 52.493 1.00 46.97 C

ATOM 6532 OG SER A 433 21.513 32.412 51.072 1.00 Al.61 O

ATOM 6534 C SER A 433 21.414 33.251 54.795 1.00 45.97 C

ATOM 6535 O SER A 433 20.426 33.093 55.543 1.00 49.16 O

ATOM 6536 N ASP A 434 22.636 33.142 55.246 1.00 43.68 N

ATOM 6538 CA ASP A 434 22.897 32.829 56.616 1.00 44.35 C

ATOM 6540 CB ASP A 434 23.092 31.311 56.710 1.00 46.18 C

ATOM 6543 CG ASP A 434 22.775 30.720 58.098 1.00 49.52 C

ATOM 6544 ODl ASP A 434 22.139 31.350 58.999 1.00 50.92 O

ATOM 6545 OD2 ASP A 434 23.167 29.561 58.374 1.00 53.17 O

ATOM 6546 C ASP A 434 24.121 33.598 57.103 1.00 41.73 C

ATOM 6547 O ASP A 434 24.857 34.175 56.338 1.00 39.17 O

ATOM 6548 N GLY A 435 24.301 33.626 58.413 1.00 43.10 N

ATOM 6550 CA GLY A 435 25.468 34.230 59.044 1.00 41.52 C

ATOM 6553 C GLY A 435 25.300 35.685 59.493 1.00 40.59 C

ATOM 6554 O GLY A 435 24.326 36.283 59.093 1.00 42.87 O

ATOM 6555 N ASP A 436 26.244 36.248 60.256 1.00 38.15 N

ATOM 6557 CA ASP A 436 26.162 37.608 60.633 1.00 37.69 C

ATOM 6559 CB ASP A 436 26.451 37.759 62.063 1.00 38.84 C

ATOM 6562 CG ASP A 436 25.542 36.897 62.949 1.00 45.93 C

ATOM 6563 ODl ASP A 436 24.475 36.346 62.465 1.00 50.44 O

ATOM 6564 OD2 ASP A 436 25.849 36.744 64.188 1.00 48.71 O

ATOM 6565 C ASP A 436 27.101 38.463 59.884 1.00 35.36 C

ATOM 6566 O ASP A 436 28.171 38.045 59.505 1.00 34.46 O

ATOM 6567 N VAL A 437 26.675 39.699 59.666 1.00 34.91 N

ATOM 6569 CA VAL A 437 27.539 40.698 59.138 1.00 32.89 C

ATOM 6571 CB VAL A 437 26.807 41.670 58.331 1.00 33.15 C

ATOM 6573 CGl VAL A 437 27.752 42.703 57.809 1.00 33.08 C

ATOM 6577 CG2 VAL A 437 26.255 40.973 57.202 1.00 34.45 C

ATOM 6581 C VAL A 437 28.177 41.428 60.248 1.00 32.40 C

ATOM 6582 O VAL A 437 27.550 41.789 61.196 1.00 33.85 O

ATOM 6583 N ILE A 438 29.465 41.596 60.128 1.00 31.56 N

ATOM 6585 CA ILE A 438 30.196 42.496 60.980 1.00 32.05 C

ATOM 6587 CB ILE A 438 31.067 41.725 62.017 1.00 31.78 C

ATOM 6589 CGl ILE A 438 31.917 42.722 62.782 1.00 33.81 C

ATOM 6592 CDl ILE A 438 31.980 42.501 64.214 1.00 34.56 C

ATOM 6596 CG2 ILE A 438 31.869 40.711 61.404 1.00 28.81 C

ATOM 6600 C ILE A 438 31.049 43.403 60.138 1.00 30.73 C

ATOM 6601 O ILE A 438 31.771 42.980 59.286 1.00 30.46 O

ATOM 6602 N ILE A 439 30.969 44.668 60.434 1.00 31.67 N

ATOM 6604 CA ILE A 439 31.661 45.697 59.693 1.00 31.64 C

ATOM 6606 CB ILE A 439 30.627 46.403 58.860 1.00 33.32 C

ATOM 6608 CGl ILE A 439 30.097 45.368 57.903 1.00 33.68 C

ATOM 6611 CDl ILE A 439 29.445 45.900 56.843 1.00 37.03 C

ATOM 6615 CG2 ILE A 439 31.173 47.672 58.251 1.00 32.18 C

ATOM 6619 C ILE A 439 32.188 46.642 60.672 1.00 32.06 C

ATOM 6620 O ILE A 439 31.404 47.452 61.174 1.00 33.52 O

ATOM 6621 N SER A 440 33.472 46.512 60.990 1.00 31.48 N

ATOM 6623 CA SER A 440 34.064 47.352 61.993 1.00 32.75 C ATOM 6625 CB SER A 440 34.033 46.654 63.346 1.00 34.08 C

ATOM 6628 OG SER A 440 35.219 46.099 63.813 1.00 30.62 O

ATOM 6630 C SER A 440 35.423 47.965 61.710 1.00 33.20 C

ATOM 6631 O SER A 440 36.301 47.431 61.050 1.00 31.65 O

ATOM 6632 N GLY A 441 35.564 49.154 62.243 1.00 34.51 N

ATOM 6634 CA GLY A 441 36.833 49.803 62.243 1.00 35.00 C

ATOM 6637 C GLY A 441 37.257 50.356 60.936 1.00 34.41 C

ATOM 6638 O GLY A 441 38.416 50.475 60.699 1.00 36.85 O

ATOM 6639 N ASN A 442 36.327 50.764 60.121 1.00 34.47 N

ATOM 6641 CA ASN A 442 36.633 51.433 58.902 1.00 34.18 C

ATOM 6643 CB ASN A 442 35.722 50.813 57.889 1.00 32.80 C

ATOM 6646 CG ASN A 442 35.795 49.277 57.918 1.00 31.45 C

ATOM 6647 ODl ASN A 442 36.767 48.706 57.513 1.00 31.51 O

ATOM 6648 ND2 ASN A 442 34.759 48.620 58.385 1.00 33.37 N

ATOM 6651 C ASN A 442 36.483 52.975 59.097 1.00 36.49 C

ATOM 6652 O ASN A 442 35.399 53.472 58.871 1.00 37.28 O

ATOM 6653 N LYS A 443 37.537 53.694 59.570 1.00 37.27 N

ATOM 6655 CA LYS A 443 37.443 55.111 59.920 1.00 40.56 C

ATOM 6657 CB LYS A 443 38.759 55.895 59.850 1.00 42.83 C

ATOM 6660 CG LYS A 443 39.988 55.442 60.495 1.00 45.94 C

ATOM 6663 CD LYS A 443 41.237 56.329 60.166 1.00 47.16 C

ATOM 6666 CE LYS A 443 42.546 55.495 60.405 1.00 49.15 C

ATOM 6669 NZ LYS A 443 43.707 55.709 59.389 1.00 50.56 N

ATOM 6673 C LYS A 443 36.582 55.947 58.945 1.00 42.61 C

ATOM 6674 O LYS A 443 35.994 56.946 59.344 1.00 44.63 O

ATOM 6675 N ASN A 444 36.652 55.608 57.658 1.00 42.59 N

ATOM 6677 CA ASN A 444 36.171 56.418 56.545 1.00 44.01 C

ATOM 6679 CB ASN A 444 37.294 56.464 55.497 1.00 44.13 C

ATOM 6682 CG ASN A 444 38.405 57.361 55.910 1.00 46.10 C

ATOM 6683 ODl ASN A 444 38.183 58.301 56.639 1.00 50.68 O

ATOM 6684 ND2 ASN A 444 39.594 57.100 55.461 1.00 47.38 N

ATOM 6687 C ASN A 444 34.921 55.847 55.902 1.00 43.68 C

ATOM 6688 O ASN A 444 34.542 56.270 54.825 1.00 45.84 O

ATOM 6689 N LEU A 445 34.283 54.866 56.539 1.00 42.24 N

ATOM 6691 CA LED A 445 33.301 54.082 55.849 1.00 41.55 C

ATOM 6693 CB LEU A 445 33.208 52.701 56.401 1.00 38.97 C

ATOM 6696 CG LEU A 445 32.117 51.924 55.680 1.00 39.43 C

ATOM 6698 CDl LEU A 445 32.454 51.904 54.221 1.00 41.08 C

ATOM 6702 CD2 LEU A 445 31.954 50.485 56.169 1.00 37.35 C

ATOM 6706 C LEU A 445 31.995 54.746 56.056 1.00 44.65 C

ATOM 6707 O LEU A 445 31.635 55.160 57.193 1.00 46.34 O

ATOM 6708 N CYS A 446 31.267 54.879 54.966 1.00 45.65 N

ATOM 6710 CA CYS A 446 29.956 55.494 55.049 1.00 47.96 C

ATOM 6712 CB CYS A 446 29.980 56.842 54.346 1.00 51.65 C

ATOM 6715 SG CYS A 446 30.690 58.223 55.323 1.00 56.94 S

ATOM 6716 C CYS A 446 28.930 54.580 54.454 1.00 45.78 C

ATOM 6717 O CYS A 446 29.247 53.516 53.948 1.00 45.34 O

ATOM 6718 N TYR A 447 27.698 54.972 54.622 1.00 46.60 N

ATOM 6720 CA TYR A 447 26.536 54.438 53.926 1.00 46.93 C

ATOM 6722 CB TYR A 447 26.727 54.312 52.366 1.00 46.78 C

ATOM 6725 CG TYR A 447 27.370 55.536 51.702 1.00 48.48 C

ATOM 6726 CDl TYR A 447 28.763 55.661 51.604 1.00 48.29 C

ATOM 6728 CEl TYR A 447 29.359 56.796 51.020 1.00 49.65 C

ATOM 6730 CZ TYR A 447 28.561 57.823 50.584 1.00 53.33 C

ATOM 6731 OH TYR A 447 29.156 58.934 50.022 1.00 56.47 O

ATOM 6733 CE2 TYR A 447 27.188 57.718 50.684 1.00 52.55 C

ATOM 6735 CD2 TYR A 447 26.603 56.594 51.237 1.00 50.12 C

ATOM 6737 C TYR A 447 26.006 53.182 54.579 1.00 45.12 C

ATOM 6738 O TYR A 447 24.828 52.906 54.450 1.00 46.05 O

ATOM 6739 N ALA A 448 26.825 52.441 55.307 1.00 42.46 N

ATOM 6741 CA ALA A 448 26.412 51.097 55.672 1.00 42.12 C

ATOM 6743 CB ALA A 448 27.486 50.466 56.386 1.00 40.08 C

ATOM 6747 C ALA A 448 25.164 51.065 56.550 1.00 45.51 C

ATOM 6748 O ALA A 448 24.377 50.118 56.546 1.00 46.84 O

ATOM 6749 N ASN A 449 25.042 52.116 57.349 1.00 48.30 N

ATOM 6751 CA ASN A 449 24.032 52.298 58.385 1.00 50.40 C

ATOM 6753 CB ASN A 449 24.550 53.507 59.267 1.00 51.87 C

ATOM 6756 CG ASN A 449 24.734 54.895 58.395 1.00 57.64 C ATOM 6757 ODl ASN A 449 25.688 55.006 57.531 1.00 53.24 O

ATOM 6758 ND2 ASN A 449 23.747 55.920 58.585 1.00 59.18 N

ATOM 6761 C ASN A 449 22.672 52.509 57.647 1.00 52.26 C

ATOM 6762 O ASN A 449 21.637 52.128 58.077 1.00 53.29 O

ATOM 6763 N THR A 450 22.728 53.091 56.469 1.00 53.13 N

ATOM 6765 CA THR A 450 21.597 53.268 55.534 1.00 54.99 C

ATOM 6767 CB THR A 450 22.266 53.742 54.252 1.00 54.62 C

ATOM 6769 OGl THR A 450 22.367 55.152 54.295 1.00 55.61 O

ATOM 6771 CG2 THR A 450 21.443 53.564 53.124 1.00 57.50 C

ATOM 6775 C THR A 450 20.713 52.104 55.065 1.00 55.13 C

ATOM 6776 O THR A 450 19.534 52.252 54.725 1.00 57.64 O

ATOM 6777 N ILE A 451 21.340 50.971 54.847 1.00 53.09 N

ATOM 6779 CA ILE A 451 20.639 49.838 54.231 1.00 52.81 C

ATOM 6781 CB ILE A 451 21.672 48.959 53.650 1.00 48.99 C

ATOM 6783 CGl ILE A 451 21.964 49.458 52.272 1.00 48.98 C

ATOM 6786 CDl ILE A 451 23.287 48.919 51.907 1.00 51.48 C

ATOM 6790 CG2 ILE A 451 21.238 47.512 53.660 1.00 48.80 C

ATOM 6794 C ILE A 451 19.855 49.041 55.251 1.00 53.28 C

ATOM 6795 O ILE A 451 20.291 48.882 56.403 1.00 53.75 O

ATOM 6796 N ASN A 452 18.729 48.501 54.859 1.00 54.61 N

ATOM 6798 CA ASN A 452 18.075 47.564 55.753 1.00 54.85 C

ATOM 6800 CB ASN A 452 16.582 47.583 55.595 1.00 58.78 C

ATOM 6803 CG ASN A 452 15.898 46.688 56.573 1.00 60.06 C

ATOM 6804 ODl ASN A 452 16.477 46.247 57.535 1.00 60.16 O

ATOM 6805 ND2 ASN A 452 14.630 46.447 56.348 1.00 66.13 N

ATOM 6808 C ASN A 452 18.584 46.161 55.514 1.00 51.88 C

ATOM 6809 O ASN A 452 18.079 45.429 54.688 1.00 51.93 O

ATOM 6810 N TRP A 453 19.574 45.788 56.289 1.00 49.02 N

ATOM 6812 CA TRP A 453 20.200 44.509 56.111 1.00 47.00 C

ATOM 6814 CB TRP A 453 21.380 44.370 57.080 1.00 43.94 C

ATOM 6817 CG TRP A 453 22.510 45.291 56.788 1.00 42.79 C

ATOM 6818 CDl TRP A 453 22.646 46.594 57.203 1.00 43.19 C

ATOM 6820 NEl TRP A 453 23.832 47.126 56.749 1.00 42.40 N

ATOM 6822 CE2 TRP A 453 24.515 46.164 56.055 1.00 41.54 C

ATOM 6823 CD2 TRP A 453 23.706 44.986 56.055 1.00 40.84 C

ATOM 6824 CE3 TRP A 453 24.181 43.846 55.397 1.00 37.49 C

ATOM 6826 CZ3 TRP A 453 25.422 43.910 54.728 1.00 36.87 C

ATOM 6828 CH2 TRP A 453 26.216 45.085 54.767 1.00 37.26 C

ATOM 6830 CZ2 TRP A 453 25.771 46.226 55.419 1.00 40.29 C

ATOM 6832 C TRP A 453 19.210 43.347 56.304 1.00 48.34 C

ATOM 6833 O TRP A 453 19.523 42.225 55.960 1.00 48.61 O

ATOM 6834 N ALA A 454 18.049 43.569 56.872 1.00 50.12 N

ATOM 6836 CA ALA A 454 17.163 42.440 57.046 1.00 52.09 C

ATOM 6838 CB ALA A 454 16.100 42.742 58.175 1.00 55.94 C

ATOM 6842 C ALA A 454 16.497 41.955 55.731 1.00 52.76 C

ATOM 6843 O ALA A 454 16.033 40.830 55.669 1.00 53.28 O

ATOM 6844 N ALA A 455 16.438 42.796 54.699 1.00 53.04 N

ATOM 6846 CA ALA A 455 15.958 42.371 53.388 1.00 54.61 C

ATOM 6848 CB ALA A 455 15.611 43.600 52.415 1.00 55.56 C

ATOM 6852 C ALA A 455 17.019 41.447 52.780 1.00 52.15 C

ATOM 6853 O ALA A 455 16.713 40.564 51.986 1.00 53.84 O

ATOM 6854 N LEU A 456 18.278 41.584 53.144 1.00 48.88 N

ATOM 6856 CA LEU A 456 19.207 40.624 52.575 1.00 47.66 C

ATOM 6858 CB LEU A 456 20.629 41.111 52.554 1.00 44.76 C

ATOM 6861 CG LEU A 456 20.822 42.604 52.299 1.00 47.13 C

ATOM 6863 CDl LEU A 456 22.273 42.896 52.676 1.00 47.80 C

ATOM 6867 CD2 LEU A 456 20.538 43.052 50.860 1.00 46.95 C

ATOM 6871 C LEU A 456 19.131 39.306 53.285 1.00 47.43 C

ATOM 6872 O LEU A 456 19.433 38.295 52.722 1.00 48.81 O

ATOM 6873 N PHE A 457 18.713 39.299 54.520 1.00 48.14 N

ATOM 6875 CA PHE A 457 18.752 38.096 55.293 1.00 48.22 C

ATOM 6877 CB PHE A 457 18.711 38.449 56.766 1.00 48.21 C

ATOM 6880 CG PHE A 457 19.963 39.062 57.277 1.00 44.36 C

ATOM 6881 CDl PHE A 457 19.934 39.820 58.425 1.00 44.86 C

ATOM 6883 CEl PHE A 457 21.026 40.346 58.984 1.00 42.67 C

ATOM 6885 CZ PHE A 457 22.226 40.151 58.400 1.00 43.38 C

ATOM 6887 CE2 PHE A 457 22.294 39.405 57.247 1.00 43.86 C

ATOM 6889 CD2 PHE A 457 21.148 38.843 56.690 1.00 42.41 C ATOM 6891 C PHE A 457 17.647 37.119 54.932 1.00 51.40 C

ATOM 6892 O PHE A 457 16.662 37.500 54.357 1.00 52.54 O

ATOM 6893 N GLY A 458 17.898 35.854 55.274 1.00 52.35 N

ATOM 6895 CA GLY A 458 17.023 34.744 55.030 1.00 56.05 C

ATOM 6898 C GLY A 458 16.661 33.924 56.238 1.00 58.52 C

ATOM 6899 O GLY A 458 15.591 33.315 56.320 1.00 63.06 O

ATOM 6900 N THR A 459 17.597 33.823 57.145 1.00 57.90 N

ATOM 6902 CA THR A 459 17.361 33.198 58.447 1.00 60.11 C

ATOM 6904 CB THR A 459 18.698 32.524 59.028 1.00 58.33 C

ATOM 6906 OGl THR A 459 19.443 31.758 58.027 1.00 56.59 O

ATOM 6908 CG2 THR A 459 18.397 31.515 60.156 1.00 61.86 C

ATOM 6912 C THR A 459 16.973 34.339 59.362 1.00 60.43 C

ATOM 6913 O THR A 459 17.504 35.455 59.293 1.00 58.76 O

ATOM 6914 N SER A 460 16.055 34.063 60.248 1.00 63.77 N

ATOM 6916 CA SER A 460 15.832 34.971 61.348 1.00 64.47 C

ATOM 6918 CB SER A 460 14.427 34.808 61.931 1.00 69.15 C

ATOM 6921 OG SER A 460 14.550 34.108 63.143 1.00 71.63 O

ATOM 6923 C SER A 460 16.934 34.647 62.384 1.00 62.22 C

ATOM 6924 O SER A 460 17.590 33.555 62.356 1.00 61.49 O

ATOM 6925 N GLY A 461 17.164 35.602 63.277 1.00 60.59 N

ATOM 6927 CA GLY A 461 18.316 35.494 64.123 1.00 57.63 C

ATOM 6930 C GLY A 461 19.585 35.989 63.511 1.00 52.41 C

ATOM 6931 O GLY A 461 20.446 36.242 64.286 1.00 52.50 O

ATOM 6932 N GLN A 462 19.741 36.137 62.195 1.00 49.52 N

ATOM 6934 CA GLN A 462 20.925 36.822 61.668 1.00 45.64 C

ATOM 6936 CB GLN A 462 20.952 36.897 60.163 1.00 43.36 C

ATOM 6939 CG GLN A 462 21.317 35.605 59.465 1.00 43.36 C

ATOM 6942 CD GLN A 462 21.144 35.662 57.939 1.00 42.21 C

ATOM 6943 OEl GLN A 462 20.022 35.477 57.420 1.00 43.94 O

ATOM 6944 NE2 GLN A 462 22.221 35.915 57.237 1.00 38.31 N

ATOM 6947 C GLN A 462 21.059 38.245 62.227 1.00 46.14 C

ATOM 6948 O GLN A 462 20.063 38.974 62.410 1.00 47.92 O

ATOM 6949 N LYS A 463 22.288 38.625 62.523 1.00 44.23 N

ATOM 6951 CA LYS A 463 22.533 39.895 63.147 1.00 45.46 C

ATOM 6953 CB LYS A 463 23.017 39.668 64.596 1.00 46.79 C

ATOM 6956 CG LYS A 463 21.984 38.954 65.430 1.00 55.05 C

ATOM 6959 CD LYS A 463 22.139 39.020 67.026 1.00 59.62 C

ATOM 6962 CE LYS A 463 20.716 38.916 67.717 1.00 64.36 C

ATOM 6965 NZ LYS A 463 20.821 38.672 69.237 1.00 69.48 N

ATOM 6969 C LYS A 463 23.603 40.691 62.389 1.00 42.96 C

ATOM 6970 O LYS A 463 24.382 40.166 61.581 1.00 39.97 O

ATOM 6971 N THR A 464 23.730 41.932 62.818 1.00 43.35 N

ATOM 6973 CA THR A 464 24.580 42.878 62.188 1.00 42.23 C

ATOM 6975 CB THR A 464 23.583 43.748 61.509 1.00 44.72 C

ATOM 6977 OGl THR A 464 23.198 43.095 60.276 1.00 46.76 O

ATOM 6979 CG2 THR A 464 24.182 45.089 61.116 1.00 46.18 C

ATOM 6983 C THR A 464 25.331 43.693 63.198 1.00 41.03 C

ATOM 6984 O THR A 464 24.720 44.166 64.099 1.00 43.87 O

ATOM 6985 N LYS A 465 26.616 43.918 63.032 1.00 38.29 N

ATOM 6987 CA LYS A 465 27.350 44.883 63.862 1.00 37.96 C

ATOM 6989 CB LYS A 465 28.365 44.234 64.770 1.00 38.00 C

ATOM 6992 CG LYS A 465 27.843 43.601 66.020 1.00 39.95 C

ATOM 6995 CD LYS A 465 29.041 42.928 66.733 1.00 39.30 C

ATOM 6998 CE LYS A 465 28.550 41.917 67.693 1.00 43.12 C

ATOM 7001 NZ LYS A 465 29.446 41.823 68.859 1.00 47.34 N

ATOM 7005 C LYS A 465 28.107 45.855 62.997 1.00 35.71 C

ATOM 7006 O LYS A 465 29.066 45.520 62.377 1.00 34.33 O

ATOM 7007 N ILE A 466 27.686 47.083 63.039 1.00 36.59 N

ATOM 7009 CA ILE A 466 28.230 48.113 62.287 1.00 36.36 C

ATOM 7011 CB ILE A 466 27.149 48.658 61.458 1.00 37.62 C

ATOM 7013 CGl ILE A 466 26.638 47.521 60.575 1.00 39.37 C

ATOM 7016 CDl ILE A 466 25.425 47.855 59.830 1.00 43.42 C

ATOM 7020 CG2 ILE A 466 27.645 49.806 60.602 1.00 36.38 C

ATOM 7024 C ILE A 466 28.660 49.060 63.328 1.00 39.00 C

ATOM 7025 O ILE A 466 27.884 49.879 63.803 1.00 42.79 O

ATOM 7026 N ILE A 467 29.957 49.024 63.565 1.00 39.11 N

ATOM 7028 CA ILE A 467 30.596 49.432 64.779 1.00 40.37 C

ATOM 7030 CB ILE A 467 31.219 48.212 65.331 1.00 40.16 C ATOM 7032 CGl ILE A 467 30.370 47.332 66.163 1.00 42.73 C

ATOM 7035 CDl ILE A 467 31.377 45.982 66.241 1.00 40.48 C

ATOM 7039 CG2 ILE A 467 32.262 48.549 66.279 1.00 45.19 C

ATOM 7043 C ILE A 467 31.840 50.203 64.366 1.00 39.14 C

ATOM 7044 O ILE A 467 32.618 49.668 63.547 1.00 36.89 O

ATOM 7045 N SER A 468 32.116 51.332 65.040 1.00 40.22 N

ATOM 7047 CA SER A 468 33.370 52.094 64.911 1.00 39.83 C

ATOM 7049 CB SER A 468 34.462 51.450 65.689 1.00 40.10 C

ATOM 7052 OG SER A 468 35.683 52.125 65.536 1.00 44.57 O

ATOM 7054 C SER A 468 33.775 52.258 63.472 1.00 38.05 C

ATOM 7055 O SER A 468 34.825 51.854 63.028 1.00 35.32 O

ATOM 7056 N ASN A 469 32.855 52.838 62.716 1.00 39.19 N

ATOM 7058 CA ASN A 469 33.116 53.297 61.394 1.00 38.06 C

ATOM 7060 CB ASN A 469 32.120 52.660 60.473 1.00 37.00 C

ATOM 7063 CG ASN A 469 32.229 51.158 60.463 1.00 32.67 C

ATOM 7064 ODl ASN A 469 33.227 50.572 60.068 1.00 31.21 O

ATOM 7065 ND2 ASN A 469 31.183 50.536 60.930 1.00 33.32 N

ATOM 7068 C ASN A 469 33.072 54.801 61.447 1.00 40.14 C

ATOM 7069 O ASN A 469 33.215 55.332 62.487 1.00 41.27 O

ATOM 7070 N ARG A 470 32.989 55.479 60.332 1.00 42.08 N

ATOM 7072 CA ARG A 470 32.665 56.891 60.330 1.00 46.67 C

ATOM 7074 CB ARG A 470 32.810 57.409 58.920 1.00 47.34 C

ATOM 7077 CG ARG A 470 32.742 58.880 58.850 1.00 52.09 C

ATOM 7080 CD ARG A 470 34.050 59.464 58.571 1.00 55.79 C

ATOM 7083 NE ARG A 470 33.944 60.651 57.785 1.00 61.59 N

ATOM 7085 CZ ARG A 470 34.946 61.179 57.104 1.00 64.65 C

ATOM 7086 NHl ARG A 470 36.169 60.602 57.129 1.00 61.27 N

ATOM 7089 NH2 ARG A 470 34.710 62.300 56.374 1.00 67.54 N

ATOM 7092 C ARG A 470 31.205 57.060 60.710 1.00 49.51 C

ATOM 7093 O ARG A 470 30.334 56.385 60.116 1.00 51.46 O

ATOM 7094 N GLY A 471 30.864 57.940 61.623 1.00 52.32 N

ATOM 7096 CA GLY A 471 29.444 58.051 61.999 1.00 54.41 C

ATOM 7099 C GLY A 471 28.409 58.690 61.044 1.00 56.89 C

ATOM 7100 O GLY A 471 28.771 59.570 60.204 1.00 58.19 O

ATOM 7101 N ALA A 472 27.117 58.276 61.201 1.00 57.50 N

ATOM 7103 CA ALA A 472 25.991 58.836 60.402 1.00 59.48 C

ATOM 7105 CB ALA A 472 24.529 58.422 60.926 1.00 59.82 C

ATOM 7109 C ALA A 472 26.180 60.340 60.361 1.00 62.54 C

ATOM 7110 O ALA A 472 25.935 60.936 59.337 1.00 64.71 O

ATOM 7111 N ASN A 473 26.708 60.910 61.448 1.00 63.09 N

ATOM 7113 CA ASN A 473 26.888 62.359 61.610 1.00 66.39 C

ATOM 7115 CB ASN A 473 27.229 62.615 63.117 1.00 67.84 C

ATOM 7118 CG ASN A 473 27.465 64.101 63.481 1.00 71.47 C

ATOM 7119 ODl ASN A 473 28.533 64.653 63.201 1.00 72.56 O

ATOM 7120 ND2 ASN A 473 26.517 64.702 64.181 1.00 70.68 N

ATOM 7123 C ASN A 473 27.912 62.992 60.665 1.00 66.37 C

ATOM 7124 O ASN A 473 27.616 63.960 60.011 1.00 68.02 O

ATOM 7125 N ALA A 474 29.133 62.452 60.621 1.00 65.12 N

ATOM 7127 CA ALA A 474 30.220 63.060 59.830 1.00 65.88 C

ATOM 7129 CB ALA A 474 31.554 62.342 60.019 1.00 62.40 C

ATOM 7133 C ALA A 474 29.778 62.956 58.411 1.00 66.42 C

ATOM 7134 O ALA A 474 29.829 63.943 57.670 1.00 69.09 O

ATOM 7135 N CYS A 475 29.294 61.756 58.068 1.00 64.28 N

ATOM 7137 CA CYS A 475 28.846 61.446 56.715 1.00 64.60 C

ATOM 7139 CB CYS A 475 28.276 60.046 56.655 1.00 61.39 C

ATOM 7142 SG CYS A 475 29.609 58.840 57.005 1.00 61.67 S

ATOM 7143 C CYS A 475 27.823 62.441 56.247 1.00 68.38 C

ATOM 7144 O CYS A 475 27.945 62.918 55.133 1.00 70.86 O

ATOM 7145 N ALA A 476 26.839 62.773 57.096 1.00 69.69 N

ATOM 7147 CA ALA A 476 25.739 63.659 56.708 1.00 73.44 C

ATOM 7149 CB ALA A 476 24.512 63.632 57.733 1.00 74.87 C

ATOM 7153 C ALA A 476 26.315 65.042 56.588 1.00 76.96 C

ATOM 7154 O ALA A 476 25.922 65.815 55.746 1.00 80.28 O

ATOM 7155 N ALA A 477 27.284 65.326 57.441 1.00 76.83 N

ATOM 7157 CA ALA A 477 27.946 66.610 57.480 1.00 79.93 C

ATOM 7159 CB ALA A 477 28.692 66.746 58.841 1.00 79.17 C

ATOM 7163 C ALA A 477 28.883 66.854 56.259 1.00 80.17 C

ATOM 7164 O ALA A 477 29.420 67.924 56.119 1.00 83.71 O ATOM 7165 N THR A 478 29.061 65.887 55.367 1.00 77.44 N

ATOM 7167 CA THR A 478 29.857 66.103 54.148 1.00 78.09 C

ATOM 7169 CB THR A 478 31.207 65.328 54.184 1.00 74.61 C

ATOM 7171 OGl THR A 478 31.657 65.181 55.522 1.00 72.75 O

ATOM 7173 CG2 THR A 478 32.284 66.181 53.526 1.00 77.14 C

ATOM 7177 C THR A 478 29.159 65.664 52.870 1.00 77.93 C

ATOM 7178 O THR A 478 29.821 65.477 51.834 1.00 78.45 O

ATOM 7179 N GLY A 479 27.857 65.436 52.920 1.00 77.46 N

ATOM 7181 CA GLY A 479 27.162 64.913 51.748 1.00 77.03 C

ATOM 7184 C GLY A 479 27.510 63.493 51.309 1.00 71.99 C

ATOM 7185 O GLY A 479 27.172 63.096 50.232 1.00 71.57 O

ATOM 7186 N GLN A 480 28.197 62.715 52.127 1.00 68.57 N

ATOM 7188 CA GLN A 480 28.453 61.317 51.786 1.00 64.64 C

ATOM 7190 CB GLN A 480 29.784 60.854 52.334 1.00 61.62 C

ATOM 7193 CG GLN A 480 30.980 61.814 52.059 1.00 64.83 C

ATOM 7196 CD GLN A 480 32.316 61.198 52.592 1.00 64.82 C

ATOM 7197 OEl GLN A 480 32.487 61.054 53.819 1.00 64.21 O

ATOM 7198 NE2 GLN A 480 33.224 60.787 51.671 1.00 62.23 N

ATOM 7201 C GLN A 480 27.227 60.525 52.300 1.00 63.37 C

ATOM 7202 O GLN A 480 27.260 59.788 53.314 1.00 61.12 O

ATOM 7203 N VAL A 481 26.162 60.692 51.514 1.00 64.68 N

ATOM 7205 CA VAL A 481 24.809 60.368 51.872 1.00 65.06 C

ATOM 7207 CB VAL A 481 24.167 61.693 52.392 1.00 69.11 C

ATOM 7209 CGl VAL A 481 22.737 61.873 51.999 1.00 71.00 C

ATOM 7213 CG2 VAL A 481 24.349 61.727 53.885 1.00 68.55 C

ATOM 7217 C VAL A 481 24.142 59.795 50.629 1.00 65.55 C

ATOM 7218 O VAL A 481 24.589 60.047 49.535 1.00 66.48 O

ATOM 7219 N CYS A 482 23.053 59.055 50.768 1.00 69.26 N

ATOM 7221 CA CYS A 482 22.381 58.508 49.580 1.00 68.72 C

ATOM 7223 CB CYS A 482 21.207 57.639 49.988 1.00 67.54 C

ATOM 7226 SG CYS A 482 21.874 56.056 50.630 1.00 70.71 S

ATOM 7227 C CYS A 482 21.898 59.552 48.623 1.00 69.13 C

ATOM 7228 O CYS A 482 21.270 60.487 49.030 1.00 70.33 O

ATOM 7229 N HIS A 483 22.230 59.344 47.354 1.00 68.81 N

ATOM 7231 CA HIS A 483 21.865 60.191 46.211 1.00 69.88 C

ATOM 7233 CB HIS A 483 22.206 59.481 44.903 1.00 68.48 C

ATOM 7236 CG HIS A 483 22.273 60.355 43.700 1.00 69.95 C

ATOM 7237 NDl HIS A 483 23.344 60.319 42.843 1.00 71.52 N

ATOM 7239 CEl HIS A 483 23.138 61.154 41.840 1.00 72.59 C

ATOM 7241 NE2 HIS A 483 21.952 61.697 41.998 1.00 71.71 N

ATOM 7243 CD2 HIS A 483 21.383 61.207 43.144 1.00 70.25 C

ATOM 7245 C HIS A 483 20.394 60.442 46.219 1.00 70.55 C

ATOM 7246 O HIS A 483 19.633 59.603 46.639 1.00 69.08 O

ATOM 7247 N ALA A 484 20.033 61.644 Ab. Ill 1.00 73.54 N

ATOM 7249 CA ALA A 484 18.667 62.058 45.466 1.00 74.84 C

ATOM 7251 CB ALA A 484 18.715 63.282 44.604 1.00 77.22 C

ATOM 7255 C ALA A 484 17.804 60.997 44.766 1.00 73.78 C

ATOM 7256 O ALA A 484 16.634 60.816 45.150 1.00 74.54 O

ATOM 7257 N LEU A 485 18.360 60.294 43.758 1.00 72.45 N

ATOM 7259 CA LEU A 485 17.549 59.450 42.876 1.00 70.78 C

ATOM 7261 CB LEU A 485 18.233 59.189 41.526 1.00 69.85 C

ATOM 7264 CG LEU A 485 18.417 60.352 40.554 1.00 71.18 C

ATOM 7266 CDl LEU A 485 19.226 59.942 39.360 1.00 68.77 C

ATOM 7270 CD2 LEU A 485 17.087 60.885 40.150 1.00 71.99 C

ATOM 7274 C LEU A 485 17.292 58.146 43.572 1.00 68.77 C

ATOM 7275 O LEU A 485 16.758 57.226 42.968 1.00 67.85 O

ATOM 7276 N CYS A 486 17.658 58.059 44.846 1.00 68.16 N

ATOM 7278 CA CYS A 486 17.418 56.844 45.588 1.00 66.85 C

ATOM 7280 CB CYS A 486 18.531 56.547 46.571 1.00 66.88 C

ATOM 7283 SG CYS A 486 20.068 56.462 45.781 1.00 68.62 S

ATOM 7284 C CYS A 486 16.216 56.889 46.426 1.00 66.34 C

ATOM 7285 O CYS A 486 15.944 57.829 47.074 1.00 66.83 O

ATOM 7286 N SER A 487 15.563 55.767 46.427 1.00 65.87 N

ATOM 7288 CA SER A 487 14.601 55.373 47.382 1.00 67.61 C

ATOM 7290 CB SER A 487 14.455 53.894 47.096 1.00 66.72 C

ATOM 7293 OG SER A 487 13.753 53.245 48.093 1.00 71.71 O

ATOM 7295 C SER A 487 15.053 55.580 48.835 1.00 68.27 C

ATOM 7296 O SER A 487 16.270 55.700 49.159 1.00 68.64 O ATOM 7297 N PRO A 488 14.094 55.577 49.752 1.00 69.67 N

ATOM 7298 CA PRO A 488 14.443 55.564 51.181 1.00 69.32 C

ATOM 7300 CB PRO A 488 13.149 56.052 51.860 1.00 71.17 C

ATOM 7303 CG PRO A 488 12.071 55.622 50.953 1.00 72.01 C

ATOM 7306 CD PRO A 488 12.636 55.635 49.538 1.00 71.29 C

ATOM 7309 C PRO A 488 14.869 54.179 51.626 1.00 67.39 C

ATOM 7310 O PRO A 488 14.883 53.915 52.804 1.00 67.71 O

ATOM 7311 N GLU A 489 15.262 53.315 50.688 1.00 66.05 N

ATOM 7313 CA GLU A 489 15.650 51.931 50.990 1.00 64.34 C

ATOM 7315 CB GLU A 489 14.944 51.012 49.979 1.00 64.65 C

ATOM 7318 CG GLU A 489 13.950 49.987 50.564 1.00 66.51 C

ATOM 7321 CD GLU A 489 13.583 48.907 49.525 1.00 69.58 C

ATOM 7322 OEl GLU A 489 13.820 47.707 49.835 1.00 69.93 O

ATOM 7323 OE2 GLU A 489 13.131 49.249 48.381 1.00 70.48 O

ATOM 7324 C GLU A 489 17.197 51.761 50.970 1.00 62.02 C

ATOM 7325 O GLU A 489 17.725 50.641 50.992 1.00 60.23 O

ATOM 7326 N GLY A 490 17.902 52.885 50.883 1.00 61.19 N

ATOM 7328 CA GLY A 490 19.311 52.942 51.176 1.00 60.24 C

ATOM 7331 C GLY A 490 20.262 52.839 50.001 1.00 59.52 C

ATOM 7332 O GLY A 490 19.800 52.615 48.891 1.00 59.65 O

ATOM 7333 N CYS A 491 21.577 52.973 50.241 1.00 58.69 N

ATOM 7335 CA CYS A 491 22.579 52.834 49.190 1.00 58.30 C

ATOM 7337 CB CYS A 491 23.088 54.159 48.688 1.00 59.18 C

ATOM 7340 SG CYS A 491 23.678 55.247 49.964 1.00 59.51 S

ATOM 7341 C CYS A 491 23.768 52.133 49.698 1.00 58.17 C

ATOM 7342 O CYS A 491 23.906 52.025 50.870 1.00 60.09 O

ATOM 7343 N TRP A 492 24.644 51.722 48.785 1.00 57.47 N

ATOM 7345 CA TRP A 492 25.960 51.167 49.054 1.00 57.58 C

ATOM 7347 CB TRP A 492 26.198 49.914 48.208 1.00 57.23 C

ATOM 7350 CG TRP A 492 25.251 48.846 48.427 1.00 56.66 C

ATOM 7351 CDl TRP A 492 24.125 48.616 47.769 1.00 56.12 C

ATOM 7353 NEl TRP A 492 23.504 47.505 48.257 1.00 56.13 N

ATOM 7355 CE2 TRP A 492 24.257 47.030 49.275 1.00 56.67 C

ATOM 7356 CD2 TRP A 492 25.367 47.843 49.384 1.00 56.95 C

ATOM 7357 CE3 TRP A 492 26.323 47.539 50.332 1.00 57.68 C

ATOM 7359 CZ3 TRP A 492 26.133 46.504 51.114 1.00 58.09 C

ATOM 7361 CH2 TRP A 492 25.012 45.719 50.987 1.00 57.91 C

ATOM 7363 CZ2 TRP A 492 24.068 45.969 50.056 1.00 57.20 C

ATOM 7365 C TRP A 492 26.997 52.155 48.596 1.00 58.58 C

ATOM 7366 O TRP A 492 28.024 51.764 48.120 1.00 59.09 O

ATOM 7367 N GLY A 493 26.736 53.443 48.717 1.00 59.23 N

ATOM 7369 CA GLY A 493 27.584 54.415 48.045 1.00 60.57 C

ATOM 7372 C GLY A 493 26.905 55.667 47.512 1.00 61.34 C

ATOM 7373 O GLY A 493 25.700 55.817 47.542 1.00 60.80 O

ATOM 7374 N PRO A 494 27.715 56.602 47.067 1.00 63.04 N

ATOM 7375 CA PRO A 494 27.223 57.926 46.798 1.00 65.24 C

ATOM 7377 CB PRO A 494 28.514 58.706 46.562 1.00 67.15 C

ATOM 7380 CG PRO A 494 29.467 57.738 46.091 1.00 66.26 C

ATOM 7383 CD PRO A 494 29.148 56.516 46.802 1.00 64.20 C

ATOM 7386 C PRO A 494 26.328 57.929 45.573 1.00 66.33 C

ATOM 7387 O PRO A 494 25.317 58.597 45.559 1.00 68.00 O

ATOM 7388 N GLU A 495 26.684 57.109 44.592 1.00 66.87 N

ATOM 7390 CA GLU A 495 26.191 57.194 43.228 1.00 67.29 C

ATOM 7392 CB GLU A 495 27.262 56.599 42.343 1.00 67.64 C

ATOM 7395 CG GLU A 495 28.401 57.573 42.148 1.00 71.68 C

ATOM 7398 CD GLU A 495 29.577 56.927 41.440 1.00 76.82 C

ATOM 7399 OEl GLU A 495 29.470 55.740 40.951 1.00 75.08 O

ATOM 7400 OE2 GLU A 495 30.632 57.625 41.377 1.00 82.21 O

ATOM 7401 C GLU A 495 24.837 56.544 42.919 1.00 65.80 C

ATOM 7402 O GLU A 495 24.367 55.692 43.676 1.00 63.46 O

ATOM 7403 N PRO A 496 24.192 56.963 41.810 1.00 67.18 N

ATOM 7404 CA PRO A 496 22.872 56.413 41.435 1.00 65.83 C

ATOM 7406 CB PRO A 496 22.428 57.256 40.256 1.00 66.55 C

ATOM 7409 CG PRO A 496 23.607 57.978 39.815 1.00 69.03 C

ATOM 7412 CD PRO A 496 24.636 58.013 40.872 1.00 69.18 C

ATOM 7415 C PRO A 496 22.869 54.918 41.127 1.00 64.10 C

ATOM 7416 O PRO A 496 21.872 54.322 41.478 1.00 64.50 O

ATOM 7417 N ARG A 497 23.927 54.318 40.585 1.00 63.43 N ATOM 7419 CA ARG A 497 23.998 52.856 40.554 1.00 61.81 C

ATOM 7421 CB ARG A 497 25.102 52.371 39.600 1.00 62.79 C

ATOM 7424 CG ARG A 497 26.384 53.144 39.609 1.00 64.56 C

ATOM 7427 CD ARG A 497 27.644 52.336 39.155 1.00 65.35 C

ATOM 7430 NE ARG A 497 28.741 52.771 40.030 1.00 68.46 N

ATOM 7432 CZ ARG A 497 30.025 52.441 39.960 1.00 68.79 C

ATOM 7433 NHl ARG A 497 30.472 51.636 39.000 1.00 68.43 N

ATOM 7436 NH2 ARG A 497 30.864 52.943 40.888 1.00 69.25 N

ATOM 7439 C ARG A 497 24.213 52.199 41.913 00 60.94 C

ATOM 7440 O ARG A 497 24.213 50.997 42.032 1.00 60.39 O

ATOM 7441 N ASP A 498 24.436 52.990 42.939 1.00 61.84 N

ATOM 7443 CA ASP A 498 24.624 52.484 44.285 1.00 60.98 C

ATOM 7445 CB ASP A 498 25.579 53.410 45.067 1.00 62.53 C

ATOM 7448 CG ASP A 498 27.019 53.424 44.503 1.00 62.37 C

ATOM 7449 ODl ASP A 498 27.333 52.507 43.754 1.00 63.21 O

ATOM 7450 OD2 ASP A 498 27.902 54.266 44.765 1.00 61.45 O

ATOM 7451 C ASP A 498 23.314 52.291 45.059 1.00 60.30 C

ATOM 7452 O ASP A 498 23.324 51.685 46.104 1.00 58.31 O

ATOM 7453 N CYS A 499 22.172 52.740 44.543 1.00 61.23 N

ATOM 7455 CA CYS A 499 20.943 52.486 45.291 1.00 61.84 C

ATOM 7457 CB CYS A 499 19.812 53.357 44.872 1.00 62.74 C

ATOM 7460 SG CYS A 499 20.331 54.978 44.411 1.00 66.84 S

ATOM 7461 C CYS A 499 20.433 51.076 45.244 1.00 61.36 C

ATOM 7462 O CYS A 499 20.878 50.243 44.460 1.00 61.72 O

ATOM 7463 N VAL A 500 19.488 50.844 46.136 1.00 61.48 N

ATOM 7465 CA VAL A 500 18.869 49.574 46.344 1.00 61.04 C

ATOM 7467 CB VAL A 500 18.561 49.388 47.868 1.00 61.98 C

ATOM 7469 CGl VAL A 500 17.793 48.079 48.131 1.00 63.20 C

ATOM 7473 CG2 VAL A 500 19.840 49.433 48.728 1.00 60.20 C

ATOM 7477 C VAL A 500 17.588 49.573 45.554 1.00 61.08 C

ATOM 7478 O VAL A 500 17.157 48.532 45.141 1.00 61.21 O

ATOM 7479 N SER A 501 16.978 50.746 45.391 1.00 61.78 N

ATOM 7481 CA SER A 501 15.715 50.963 44.651 1.00 62.67 C

ATOM 7483 CB SER A 501 14.496 50.409 45.457 1.00 63.41 C

ATOM 7486 OG SER A 501 14.295 50.992 46.745 1.00 62.89 O

ATOM 7488 C SER A 501 15.580 52.495 44.276 1.00 64.49 C

ATOM 7489 O SER A 501 16.205 53.346 44.915 1.00 65.53 O

ATOM 7490 N CYS A 502 14.796 52.870 43.271 1.00 65.42 N

ATOM 7492 CA CYS A 502 14.828 54.267 42.789 1.00 67.75 C

ATOM 7494 CB CYS A 502 14.768 54.264 41.279 1.00 67.77 C

ATOM 7497 SG CYS A 502 16.221 53.363 40.726 1.00 74.29 S

ATOM 7498 C CYS A 502 13.720 55.123 43.312 1.00 68.44 C

ATOM 7499 O CYS A 502 12.717 54.556 43.656 1.00 69.58 O

ATOM 7500 N ALA A 503 13.838 56.455 43.368 1.00 68.92 N

ATOM 7502 CA ALA A 503 12.653 57.227 43.798 1.00 71.83 C

ATOM 7504 CB ALA A 503 12.941 58.787 44.045 1.00 73.74 C

ATOM 7508 C ALA A 503 11.611 57.004 42.683 1.00 72.91 C

ATOM 7509 O ALA A 503 10.457 56.658 42.934 1.00 72.96 O

ATOM 7510 N ASN A 504 12.089 57.121 41.445 1.00 72.99 N

ATOM 7512 CA ASN A 504 11.256 57.123 40.243 1.00 74.36 C

ATOM 7514 CB ASN A 504 11.575 58.361 39.406 1.00 75.32 C

ATOM 7517 CG ASN A 504 11.494 59.602 40.235 1.00 78.00 C

ATOM 7518 ODl ASN A 504 10.412 60.228 40.359 1.00 82.73 O

ATOM 7519 ND2 ASN A 504 12.596 59.937 40.899 1.00 75.00 N

ATOM 7522 C ASN A 504 11.434 55.846 39.457 1.00 73.02 C

ATOM 7523 O ASN A 504 10.662 54.873 39.645 1.00 72.93 O

ATOM 7524 N VAL A 505 12.501 55.828 38.644 1.00 72.34 N

ATOM 7526 CA VAL A 505 12.729 54.790 37.645 1.00 70.30 C

ATOM 7528 CB VAL A 505 12.389 55.347 36.278 1.00 71.79 C

ATOM 7530 CGl VAL A 505 12.524 54.251 35.263 1.00 71.94 C

ATOM 7534 CG2 VAL A 505 11.011 55.887 36.245 1.00 72.79 C

ATOM 7538 C VAL A 505 14.158 54.374 37.502 1.00 67.81 C

ATOM 7539 O VAL A 505 15.046 55.143 37.612 1.00 68.17 O

ATOM 7540 N SER A 506 14.376 53.149 37.128 1.00 66.94 N

ATOM 7542 CA SER A 506 15.736 52.664 36.881 1.00 65.51 C

ATOM 7544 CB SER A 506 15.987 51.363 37.643 1.00 63.70 C

ATOM 7547 OG SER A 506 14.880 50.489 37.521 1.00 63.05 O

ATOM 7549 C SER A 506 15.894 52.410 35.406 1.00 65.47 C ATOM 7550 O SER A 506 14.922 52.084 34.730 1.00 65.31 O

ATOM 7551 N ARG A 507 17.104 52.648 34.920 1.00 66.02 N

ATOM 7553 CA ARG A 507 17.563 52.198 33.606 1.00 66.52 C

ATOM 7555 CB ARG A 507 18.321 53.306 32.922 1.00 67.29 C

ATOM 7558 CG ARG A 507 18.520 53.085 31.458 1.00 67.04 C

ATOM 7561 CD ARG A 507 19.211 54.254 30.845 1.00 69.49 C

ATOM 7564 NE ARG A 507 18.350 55.355 30.381 1.00 72.58 N

ATOM 7566 CZ ARG A 507 18.876 56.525 29.999 1.00 77.80 C

ATOM 7567 NHl ARG A 507 20.241 56.684 30.043 1.00 76.65 N

ATOM 7570 NH2 ARG A 507 18.076 57.514 29.521 1.00 79.53 N

ATOM 7573 C ARG A 507 18.500 51.002 33.751 1.00 66.50 C

ATOM 7574 O ARG A 507 19.747 51.161 33.656 1.00 66.13 O

ATOM 7575 N GLY A 508 17.900 49.833 34.047 1.00 66.65 N

ATOM 7577 CA GLY A 508 18.644 48.603 34.086 1.00 65.74 C

ATOM 7580 C GLY A 508 19.525 48.460 35.303 1.00 65.94 C

ATOM 7581 O GLY A 508 19.625 47.337 35.840 1.00 66.96 O

ATOM 7582 N ARG A 509 20.223 49.516 35.730 1.00 66.56 N

ATOM 7584 CA ARG A 509 21.083 49.445 36.964 1.00 66.64 C

ATOM 7586 CB ARG A 5,09 22.489 48.881 36.701 1.00 66.71 C

ATOM 7589 CG ARG A 509 23.298 49.663 35.556 1.00 69.61 C

ATOM 7592 CD ARG A 509 23.416 48.867 34.185 1.00 70.79 C

ATOM 7595 NE ARG A 509 24.374 49.468 33.244 1.00 73.28 N

ATOM 7597 CZ ARG A 509 25.628 48.985 32.971 1.00 75.15 C

ATOM 7598 NHl ARG A 509 26.131 47.881 33.569 1.00 71.78 N

ATOM 7601 NH2 ARG A 509 26.402 49.636 32.074 1.00 77.07 N

ATOM 7604 C ARG A 509 21.264 50.782 37.627 1.00 66.73 C

ATOM 7605 O ARG A 509 21.410 50.847 38.811 1.00 67.34 O

ATOM 7606 N GLU A 510 21.297 51.853 36.858 1.00 67.08 N

ATOM 7608 CA GLU A 510 21.459 53.183 37.434 1.00 67.32 C

ATOM 7610 CB GLU A 510 22.246 54.101 36.478 1.00 68.74 C

ATOM 7613 CG GLU A 510 21.936 55.585 36.586 1.00 70.35 C

ATOM 7616 CD GLU A 510 22.933 56.425 35.809 1.00 74.79 C

ATOM 7617 OEl GLU A 510 23.986 55.840 35.426 1.00 74.61 O

ATOM 7618 OE2 GLU A 510 22.658 57.652 35.572 1.00 77.88 O

ATOM 7619 C GLU A 510 20.078 53.729 37.693 1.00 66.81 C

ATOM 7620 O GLU A 510 19.137 53.401 36.977 1.00 66.94 O

ATOM 7621 N CYS A 511 19.959 54.554 38.719 1.00 66.39 N

ATOM 7623 CA CYS A 511 18.693 55.135 39.066 1.00 66.14 C

ATOM 7625 CB CYS A 511 18.610 55.343 40.548 1.00 65.95 C

ATOM 7628 SG CYS A 511 18.160 53.799 41.363 1.00 62.99 S

ATOM 7629 C CYS A 511 18.661 56.414 38.318 1.00 68.45 C

ATOM 7630 O CYS A 511 19.671 57.145 38.275 1.00 69.88 O

ATOM 7631 N VAL A 512 17.519 56.652 37.670 1.00 69.26 N

ATOM 7633 CA VAL A 512 17.284 57.840 36.860 1.00 71.01 C

ATOM 7635 CB VAL A 512 17.364 57.499 35.357 1.00 70.31 C

ATOM 7637 CGl VAL A 512 17.763 58.724 34.563 1.00 74.73 C

ATOM 7641 CG2 VAL A 512 18.413 56.495 35.122 1.00 69.40 C

ATOM 7645 C VAL A 512 15.961 58.568 37.218 1.00 72.75 C

ATOM 7646 O VAL A 512 14.991 57.984 37.710 1.00 71.70 O

ATOM 7647 N ASP A 513 15.953 59.871 36.952 1.00 75.55 N

ATOM 7649 CA ASP A 513 14.763 60.722 37.132 1.00 78.34 C

ATOM 7651 CB ASP A 513 15.195 62.210 37.064 1.00 82.23 C

ATOM 7654 CG ASP A 513 15.778 62.604 35.666 1.00 86.47 C

ATOM 7655 ODl ASP A 513 16.485 61.724 35.028 1.00 85.95 O

ATOM 7656 OD2 ASP A 513 15.527 63.750 35.143 1.00 89.04 O

ATOM 7657 C ASP A 513 13.600 60.486 36.136 1.00 78.00 C

ATOM 7658 O ASP A 513 12.407 60.618 36.490 1.00 78.71 O

ATOM 7659 N LYS A 514 13.936 60.184 34.885 1.00 76.63 N

ATOM 7661 CA LYS A 514 12.907 60.080 33.832 1.00 77.37 C

ATOM 7663 CB LYS A 514 12.661 61.438 33.090 1.00 79.82 C

ATOM 7670 C LYS A 514 13.389 59.087 32.841 1.00 74.72 C

ATOM 7671 O LYS A 514 14.568 58.916 32.682 1.00 71.86 O

ATOM 7672 N CYS A 515 12.473 58.478 32.118 1.00 75.49 N

ATOM 7674 CA CYS A 515 12.882 57.736 30.931 1.00 75.27 C

ATOM 7676 CB CYS A 515 11.953 56.576 30.660 1.00 74.23 C

ATOM 7679 SG CYS A 515 12.029 55.503 32.049 1.00 75.96 S

ATOM 7680 C CYS A 515 12.878 58.608 29.723 1.00 77.45 C

ATOM 7681 O CYS A 515 12.396 59.736 29.762 1.00 80.72 O ATOM 7682 N ASN A 516 13.375 58.047 28.632 1.00 76.28 N

ATOM 7684 CA ASN A 516 13.450 58.745 27.390 1.00 78.27 C

ATOM 7686 CB ASN A 516 14.682 58.263 26.628 1.00 76.82 C

ATOM 7689 CG ASN A 516 15.962 58.751 27.257 1.00 76.59 C

ATOM 7690 ODl ASN A 516 15.913 59.562 28.158 1.00 76.10 O

ATOM 7691 ND2 ASN A 516 17.118 58.255 26.792 1.00 78.58 N

ATOM 7694 C ASN A 516 12.162 58.593 26.589 1.00 79.48 C

ATOM 7695 O ASN A 516 12.214 58.369 25.392 1.00 80.32 O

ATOM 7696 N LEU A 517 11.005 58.722 27.247 1.00 80.26 N

ATOM 7698 CA LEU A 517 9.729 58.866 26.540 1.00 81.89 C

ATOM 7700 CB LEU A 517 8.536 58.802 27.508 1.00 82.29 C

ATOM 7703 CG LEU A 517 8.472 57.763 28.612 1.00 78.11 C

ATOM 7705 CDl LEO A 517 7.256 57.874 29.493 1.00 78.46 C

ATOM 7709 CD2 LEU A 517 8.494 56.410 27.960 1.00 77.57 C

ATOM 7713 C LEU A 517 9.787 60.258 25.953 1.00 85.89 C

ATOM 7714 O LEU A 517 9.879 61.252 26.730 1.00 89.33 O

ATOM 7715 N LEU A 518 9.773 60.389 24.633 1.00 86.14 N

ATOM 7717 CA LEU A 518 9.569 61.731 24.037 1.00 89.84 C

ATOM 7719 CB LEU A 518 8.620 62.609 24.906 1.00 92.23 C

ATOM 7722 CG LEU A 518 7.226 62.059 25.263 1.00 91.47 C

ATOM 7724 CDl LEU A 518 6.556 62.839 26.352 1.00 93.70 C

ATOM 7728 CD2 LEU A 518 6.382 62.115 24.048 1.00 93.66 C

ATOM 7732 C LEU A 518 10.827 62.542 23.724 1.00 90.91 C

ATOM 7733 O LEU A 518 10.733 63.588 23.093 1.00 94.73 O

ATOM 7734 N GLU A 519 11.990 62.050 24.106 1.00 88.21 N

ATOM 7736 CA GLU A 519 13.211 62.857 24.134 1.00 90.11 C

ATOM 7738 CB GLU A 519 13.100 64.031 25.150 1.00 92.09 C

ATOM 7745 C GLU A 519 14.289 61.868 24.579 1.00 87.46 C

ATOM 7746 O GLU A 519 14.162 61.310 25.671 1.00 86.35 O

ATOM 7747 N GLY A 520 15.305 61.576 23.753 1.00 87.39 N

ATOM 7749 CA GLY A 520 16.367 60.664 24.168 1.00 84.28 C

ATOM 7752 C GLY A 520 17.184 59.916 23.123 1.00 83.49 C

ATOM 7753 O GLY A 520 16.762 59.776 21.962 1.00 83.56 O

ATOM 7754 N GLU A 521 18.343 59.402 23.598 1.00 82.41 N

ATOM 7756 CA GLU A 521 19.346 58.645 22.811 1.00 81.13 C

ATOM 7758 CB GLU A 521 20.537 58.131 23.652 1.00 79.67 C

ATOM 7765 C GLU A 521 18.600 57.538 22.157 1.00 78.75 C

ATOM 7766 O GLU A 521 18.095 57.788 21.071 1.00 81.59 O

ATOM 7767 N PRO A 522 18.450 56.371 22.786 1.00 75.18 N

ATOM 7768 CA PRO A 522 17.393 55.446 22.365 1.00 72.91 C

ATOM 7770 CB PRO A 522 17.911 54.074 22.846 1.00 70.53 C

ATOM 7773 CG PRO A 522 18.755 54.376 24.063 1.00 70.29 C

ATOM 7776 CD PRO A 522 19.206 55.822 23.940 1.00 73.90 C

ATOM 7779 C PRO A 522 16.098 55.838 23.085 1.00 72.50 C

ATOM 7780 O PRO A 522 16.099 56.091 24.277 1.00 71.74 O

ATOM 7781 N ARG A 523 15.000 55.914 22.354 1.00 73.17 N

ATOM 7783 CA ARG A 523 13.700 56.209 22.950 1.00 73.74 C

ATOM 7785 CB ARG A 523 12.642 56.629 21.883 1.00 75.26 C

ATOM 7794 C ARG A 523 13.348 54.933 23.704 1.00 70.93 C

ATOM 7795 O ARG A 523 13.763 53.837 23.330 1.00 68.98 O

ATOM 7796 N GLU A 524 12.655 55.074 24.817 1.00 71.17 N

ATOM 7798 CA GLU A 524 12.390 53.915 25.690 1.00 69.50 C

ATOM 7800 CB GLU A 524 13.381 53.846 26.934 1.00 67.31 C

ATOM 7807 C GLU A 524 10.900 53.981 26.076 1.00 70.75 C

ATOM 7808 O GLU A 524 10.278 55.027 25.933 1.00 72.03 O

ATOM 7809 N PHE A 525 10.339 52.834 26.487 1.00 70.41 N

ATOM 7811 CA PHE A 525 9.073 52.756 27.238 1.00 71.56 C

ATOM 7813 CB PHE A 525 8.072 51.852 26.513 1.00 71.53 C

ATOM 7816 CG PHE A 525 8.376 50.386 26.625 1.00 68.87 C

ATOM 7817 CDl PHE A 525 7.672 49.582 27.527 1.00 66.88 C

ATOM 7819 CEl PHE A 525 7.933 48.262 27.624 1.00 65.64 C

ATOM 7821 CZ PHE A 525 8.923 47.692 26.821 1.00 65.09 C

ATOM 7823 CE2 PHE A 525 9.625 48.470 25.920 1.00 64.47 C

ATOM 7825 CD2 PHE A 525 9.348 49.810 25.824 1.00 66.17 C

ATOM 7827 C PHE A 525 9.370 52.267 28.663 1.00 70.74 C

ATOM 7828 O PHE A 525 10.511 52.060 29.014 1.00 69.95 O

ATOM 7829 N VAL A 526 8.350 52.071 29.478 1.00 72.42 N

ATOM 7831 CA VAL A 526 8.512 51.804 30.902 1.00 71.94 C ATOM 7833 CB VAL A 526 8 .002 52.989 31.696 1.00 73.98 C

ATOM 7835 CGl VAL A 526 7 . 837 52.617 33.185 1.00 75.09 C

ATOM 7839 CG2 VAL A 526 8 . 908 54.239 31.481 1.00 74.24 C

ATOM 7843 C VAL A 526 7 . 648 50.632 31.327 1.00 73.13 C

ATOM 7844 O VAL A 526 6. 495 50.506 30.870 1.00 75.47 O

ATOM 7845 N GLU A 527 8 .176 49.785 32.218 1.00 72.37 N

ATOM 7847 CA GLU A 527 7 .356 48.786 32.900 1.00 73.28 C

ATOM 7849 CB GLU A 527 7 . 025 47.568 32.001 1.00 73.10 C

ATOM 7852 CG GLU A 527 8.218 46.727 31.521 1.00 71.94 C

ATOM 7855 CD GLU A 527 7.836 45.371 30.851 1.00 72.04 C

ATOM 7856 OEl GLU A 527 6.743 45.307 30.202 1.00 69.38 O

ATOM 7857 OE2 GLU A 527 8 . 648 44.377 30.965 1.00 68.38 O

ATOM 7858 C GLU A 527 8. 000 48.365 34.226 1.00 72.76 C

ATOM 7859 O GLU A 527 9. 115 47.824 34.258 1.00 71.27 O

ATOM 7860 N ASN A 528 7 .244 48.589 35.308 1.00 74.36 N

ATOM 7862 CA ASN A 528 . 661 48.313 36.678 1.00 73.60 C

ATOM 7864 CB ASN A 528 . 986 46.830 36.923 1.00 72.97 C

ATOM 7867 CG ASN A 528 7.226 45.878 35.978 1.00 75.77 C

ATOM 7868 ODl ASN A 528 5.990 45.973 35.798 1.00 77.45 O

ATOM 7869 ND2 ASN A 528 7.978 44.952 35.353 1.00 77.81 N

ATOM 7872 C ASN A 528 8.833 49.221 36.924 1.00 71.99 C

ATOM 7873 O ASN A 528 9.871 48.815 37.396 1.00 71.09 O

ATOM 7874 N SER A 529 8.652 50.478 36.543 1.00 72.85 N

ATOM 7876 CA SER A 529 9.608 51.521 36.862 1.00 71.65 C

ATOM 7878 CB SER A 529 9.699 51.713 38.387 1.00 72.07 C

ATOM 7881 OG SER A 529 8.447 52.198 38.850 1.00 75.50 O

ATOM 7883 C SER A 529 10.965 51.223 36.289 1.00 68.41 C

ATOM 7884 O SER A 529 11.971 51.654 36.838 1.00 67.15 O

ATOM 7885 N GLU A 530 11.000 50.523 35.172 1.00 66.50 N

ATOM 7887 CA GLU A 530 12.270 50.325 34.533 1.00 65.30 C

ATOM 7889 CB GLU A 530 12.844 48.908 34.841 1.00 64.54 C

ATOM 7892 CG GLU A 530 12.086 47.695 34.312 1.00 67.37 C

ATOM 7895 CD GLU A 530 12.640 46.360 34.858 1.00 71.17 C

ATOM 7896 OEl GLU A 530 13.473 46.411 35.793 1.00 73.46 O

ATOM 7897 OE2 GLU A 530 12.263 45.242 34.358 1.00 73.29 O

ATOM 7898 C GLU A 530 12.191 50.692 33.060 1.00 64.85 C

ATOM 7899 O GLU A 530 11.152 50.638 32.500 1.00 65.79 O

ATOM 7900 N CYS A 531 13.302 51.128 32.477 1.00 64.45 N

ATOM 7902 CA CYS A 531 13.370 51.702 31.133 1.00 65.38 C

ATOM 7904 CB CYS A 531 14.157 52.986 31.109 1.00 66.14 C

ATOM 7907 SG CYS A 531 13.296 53.919 32.284 1.00 71.12 S

ATOM 7908 C CYS A 531 14.000 50.813 30.142 1.00 64.46 C

ATOM 7909 O CYS A 531 15.195 50.531 30.187 1.00 63.28 O

ATOM 7910 N ILE A 532 13.178 50.491 29.167 1.00 65.37 N

ATOM 7912 CA ILE A 532 13.468 49.509 28.187 1.00 65.17 C

ATOM 7914 CB ILE A 532 12.381 48.517 28.302 1.00 65.55 C

ATOM 7916 CGl ILE A 532 12.447 47.966 29.713 1.00 66.66 C

ATOM 7919 CDl ILE A 532 11.359 47.069 29.980 1.00 70.19 C

ATOM 7923 CG2 ILE A 532 12.541 47.427 27.274 1.00 65.55 C

ATOM 7927 C ILE A 532 13.464 50.131 26.825 1.00 65.90 C

ATOM 7928 O ILE A 532 12.544 50.839 26.477 1.00 66.89 O

ATOM 7929 N GLN A 533 14.500 49.835 26.049 1.00 66.08 N

ATOM 7931 CA GLN A 533 14.651 50.416 24.711 1.00 67.62 C

ATOM 7933 CB GLN A 533 15.969 49.974 24.060 1.00 67.56 C

ATOM 7936 CG GLN A 533 17.233 50.681 24.519 1.00 69.80 C

ATOM 7939 CD GLN A 533 18.451 49.923 24.040 1.00 70.83 C

ATOM 7940 OEl GLN A 533 18.620 49.748 22.845 1.00 72.01 O

ATOM 7941 NE2 GLN A 533 19.251 49.412 24.962 1.00 71.14 N

ATOM 7944 C GLN A 533 13.558 49.968 23.770 1.00 67.44 C

ATOM 7945 O GLN A 533 13.113 48.818 23.791 1.00 65.57 O

ATOM 7946 N CYS A 534 13.183 50.881 22.895 1.00 68.65 N

ATOM 7948 CA CYS A 534 12.323 50.512 21.786 1.00 69.43 C

ATOM 7950 CB CYS A 534 11.753 51.740 21.154 1.00 71.08 C

ATOM 7953 SG CYS A 534 10.611 52.557 22.300 1.00 73.86 S

ATOM 7954 C CYS A 534 13.126 49.751 20.777 1.00 68.25 C

ATOM 7955 O CYS A 534 14.262 50.108 20.508 1.00 68.52 O

ATOM 7956 N HIS A 535 12.543 48.707 20.222 1.00 66.84 N

ATOM 7958 CA HIS A 535 13.212 48.012 19.163 1.00 65.78 C ATOM 7960 CB HIS A 535 12.216 47.085 18.497 1.00 66.02 C

ATOM 7963 CG HIS A 535 12.824 46.218 17.462 1.00 64.32 C

ATOM 7964 NDl HIS A 535 13.031 46.638 16.175 1.00 61.92 N

ATOM 7966 CEl HIS A 535 13.599 45.677 15.489 1.00 64.12 C

ATOM 7968 NE2 HIS A 535 13.800 44.658 16.299 1.00 65.31 N

ATOM 7970 CD2 HIS A 535 13.337 44.980 17.543 1.00 64.19 C

ATOM 7972 C HIS A 535 13.822 49.045 18.165 1.00 66.70 C

ATOM 7973 O HIS A 535 13.217 50.069 17.907 1.00 68.03 O

ATOM 7974 N PRO A 536 15.028 48.800 17.637 1.00 66.72 N

ATOM 7975 CA PRO A 536 15.804 49.881 16.971 1.00 67.56 C

ATOM 7977 CB PRO A 536 17.231 49.296 16.821 1.00 67.39 C

ATOM 7980 CG PRO A 536 17.085 47.783 16.953 1.00 66.07 C

ATOM 7983 CD PRO A 536 15.762 47.502 17.657 1.00 65.17 C

ATOM 7986 C PRO A 536 15.311 50.179 15.631 1.00 68.62 C

ATOM 7987 O PRO A 536 15.855 51.051 14.996 1.00 70.04 O

ATOM 7988 N GLO A 537 14.367 49.374 15.170 1.00 68.61 N

ATOM 7990 CA GLO A 537 13.650 49.638 13.937 1.00 69.99 C

ATOM 7992 CB GLO A 537 13.211 48.324 13.277 1.00 68.51 C

ATOM 7995 CG GLO A 537 14.325 47.611 12.610 1.00 68.09 C

ATOM 7998 CD GLO A 537 15.045 48.492 11.626 1.00 70.66 C

ATOM 7999 OEl GLO A 537 14.402 49.367 11.003 1.00 74.79 O

ATOM 8000 OE2 GLO A 537 16.267 48.319 11.485 1.00 72.71 O

ATOM 8001 C GLO A 537 12.418 50.521 14.139 1.00 71.72 C

ATOM 8002 O GLO A 537 11.672 50.711 13.201 1.00 74.11 O

ATOM 8003 N CYS A 538 12.169 51.060 15.325 1.00 71.85 N

ATOM 8005 CA CYS A 538 11.143 52.088 15.421 1.00 73.89 C

ATOM 8007 CB CYS A 538 10.500 52.152 16.780 1.00 74.04 C

ATOM 8010 SG CYS A 538 9.888 50.553 17.320 1.00 72.72 S

ATOM 8011 C CYS A 538 11.770 53.404 15.135 1.00 75.65 C

ATOM 8012 O CYS A 538 12.918 53.645 15.498 1.00 74.35 O

ATOM 8013 N LEO A 539 10.989 54.235 14.445 1.00 78.81 N

ATOM 8015 CA LEO A 539 11.368 55.584 14.097 1.00 81.09 C

ATOM 8017 CB LEO A 539 10.672 55.993 12.829 1.00 83.53 C

ATOM 8020 CG LEO A 539 11.126 57.328 12.277 1.00 86.35 C

ATOM 8022 CDl LEO A 539 12.585 57.287 11.828 1.00 85.10 C

ATOM 8026 CD2 LEO A 539 10.163 57.659 11.175 1.00 88.79 C

ATOM 8030 C LEO A 539 10.960 56.483 15.249 1.00 82.49 C

ATOM 8031 O LEO A 539 9.773 56.549 15.611 1.00 82.07 O

ATOM 8032 N PRO A 540 11.968 57.076 15.893 1.00 83.31 N

ATOM 8033 CA PRO A 540 11.736 58.147 16.878 1.00 84.93 C

ATOM 8035 CB PRO A 540 13.129 58.776 17.104 1.00 85.34 C

ATOM 8038 CG PRO A 540 14.139 57.881 16.384 1.00 84.21 C

ATOM 8041 CD PRO A 540 13.398 56.694 15.818 1.00 81.81 C

ATOM 8044 C PRO A 540 10.784 59.185 16.374 1.00 88.12 C

ATOM 8045 O PRO A 540 10.908 59.595 15.238 1.00 89.43 O

ATOM 8046 N GLN A 541 9.886 59.604 17.258 1.00 89.34 N

ATOM 8048 CA GLN A 541 8.794 60.495 16.962 1.00 92.72 C

ATOM 8050 CB GLN A 541 7.463 59.830 17.324 1.00 92.16 C

ATOM 8053 CG GLN A 541 7.171 58.527 16.577 1.00 89.77 C

ATOM 8056 CD GLN A 541 6.354 58.684 15.285 1.00 92.88 C

ATOM 8057 OEl GLN A 541 5.697 59.736 15.027 1.00 96.32 O

ATOM 8058 NE2 GLN A 541 6.385 57.629 14.462 1.00 88.98 N

ATOM 8061 C GLN A 541 8.961 61.755 17.791 1.00 95.58 C

ATOM 8062 O GLN A 541 8.962 61.700 19.017 1.00 93.76 O

ATOM 8063 N ALA A 542 9.043 62.898 17.103 1.00100.12 N

ATOM 8065 CA ALA A 542 9.171 64.199 17.758 1.00103.21 C

ATOM 8067 CB ALA A 542 9.082 65.306 16.720 1.00107.95 C

ATOM 8071 C ALA A 542 8.092 64.366 18.819 1.00104.03 C

ATOM 8072 O ALA A 542 8.396 64.498 19.999 1.00103.11 O

ATOM 8073 N MET A 543 6.834 64.281 18.400 1.00105.83 N

ATOM 8075 CA MET A 543 5.718 64.631 19.277 1.00108.35 C

ATOM 8077 CB MET A 543 4.430 64.701 18.477 1.00111.35 C

ATOM 8080 CG MET A 543 4.523 65.603 17.241 1.00116.25 C

ATOM 8083 SD MET A 543 4.822 67.395 17.470 1.00123.15 S

ATOM 8084 CE MET A 543 6.486 67.662 18.473 1.00119.09 C

ATOM 8088 C MET A 543 5.518 63.708 20.482 1.00105.56 C

ATOM 8089 O MET A 543 5.645 64.161 21.642 1.00105.64 O

ATOM 8090 N ASN A 544 5.215 62.425 20.192 1.00102.85 N ATOM 8092 CA ASN A 544 4.756 61.436 21.189 1.00 99.69 C

ATOM 8094 CB ASN A 544 3.440 60.756 20.758 1.00100.63 C

ATOM 8097 CG ASN A 544 2.311 61.737 20.593 1.00106.66 C

ATOM 8098 ODl ASN A 544 2.108 62.599 21.452 1.00113.63 O

ATOM 8099 ND2 ASN A 544 1.587 61.647 19.474 1.00107.70 N

ATOM 8102 C ASN A 544 5.730 60.329 21.403 1.00 94.33 C

ATOM 8103 O ASN A 544 6.730 60.230 20.713 1.00 93.08 O

ATOM 8104 N ILE A 545 5.400 59.553 22.433 1.00 91.45 N

ATOM 8106 CA ILE A 545 5.741 58.160 22.629 1.00 86.98 C

ATOM 8108 CB ILE A 545 4.474 57.465 23.309 1.00 86.92 C

ATOM 8110 CGl ILE A 545 4.672 57.482 24.841 00 89.02 C

ATOM 8113 CDl ILE A 545 3.522 56.919 25.781 1.00 91.04 C

ATOM 8117 CG2 ILE A 545 4.136 56.089 22.768 1.00 82.26 C

ATOM 8121 C ILE A 545 6.144 57.489 21.337 1.00 86.03 C

ATOM 8122 O ILE A 545 5.452 57.604 20.316 1.00 88.94 O

ATOM 8123 N THR A 546 7.267 56.788 21.380 1.00 82.71 N

ATOM 8125 CA THR A 546 7.828 56.125 20.215 1.00 80.76 C

ATOM 8127 CB THR A 546 9.312 56.458 20.162 1.00 79.71 C

ATOM 8129 OGl THR A 546 9.431 57.779 19.651 1.00 81.40 O

ATOM 8131 CG2 THR A 546 10.108 55.583 19.160 1.00 77.72 C

ATOM 8135 C THR A 546 7.623 54.612 20.203 1.00 78.40 C

ATOM 8136 O THR A 546 8.110 53.971 19.274 1.00 76.95 O

ATOM 8137 N CYS A 547 6.944 54.045 21.218 1.00 77.55 N

ATOM 8139 CA CYS A 547 6.542 52.622 21.189 1.00 76.32 C

ATOM 8141 CB CYS A 547 7.766 51.712 21.067 1.00 73.37 C

ATOM 8144 SG CYS A 547 8.789 51.650 22.513 1.00 73.09 S

ATOM 8145 C CYS A 547 5.688 52.116 22.344 1.00 75.94 C

ATOM 8146 O CYS A 547 5.642 52.743 23.343 1.00 76.38 O

ATOM 8147 N THR A 548 5.047 50.955 22.188 1.00 76.01 N

ATOM 8149 CA THR A 548 4.280 50.292 23.254 1.00 76.89 C

ATOM 8151 CB THR A 548 3.066 49.538 22.668 1.00 78.86 C

ATOM 8153 OGl THR A 548 2.220 50.450 21.967 1.00 82.65 O

ATOM 8155 CG2 THR A 548 2.142 48.955 23.780 1.00 80.14 C

ATOM 8159 C THR A 548 5.071 49.259 24.089 1.00 74.79 C

ATOM 8160 O THR A 548 4.572 48.822 25.099 1.00 75.56 O

ATOM 8161 N GLY A 549 6.289 48.875 23.701 1.00 72.66 N

ATOM 8163 CA GLY A 549 6.888 47.648 24.191 1.00 70.37 C

ATOM 8166 C GLY A 549 7.998 47.174 23.273 1.00 69.28 C

ATOM 8167 O GLY A 549 8.481 47.923 22.394 1.00 69.27 O

ATOM 8168 N ARG A 550 8.370 45.904 23.434 1.00 68.41 N

ATOM 8170 CA ARG A 550 9.617 45.393 22.863 1.00 66.94 C

ATOM 8172 CB ARG A 550 10.066 44.051 23.463 1.00 66.83 C

ATOM 8175 CG ARG A 550 9.594 43.646 24.804 1.00 67.69 C

ATOM 8178 CD ARG A 550 10.696 43.065 25.661 1.00 67.99 C

ATOM 8181 NE ARG A 550 10.467 43.536 27.012 1.00 68.71 N

ATOM 8183 CZ ARG A 550 11.350 43.538 27.946 1.00 68.02 C

ATOM 8184 NHl ARG A 550 12.548 43.056 27.689 1.00 71.35 N

ATOM 8187 NH2 ARG A 550 11.035 43.998 29.154 1.00 67.97 N

ATOM 8190 C ARG A 550 9.593 45.083 21.401 1.00 67.18 C

ATOM 8191 O ARG A 550 10.654 45.058 20.759 1.00 65.99 O

ATOM 8192 N GLY A 551 8.434 44.712 20.882 1.00 68.91 N

ATOM 8194 CA GLY A 551 8.428 44.078 19.566 1.00 69.72 C

ATOM 8197 C GLY A 551 8.984 44.980 18.462 1.00 69.41 C

ATOM 8198 O GLY A 551 9.184 46.175 18.685 1.00 69.05 O

ATOM 8199 N PRO A 552 9.316 44.417 17.307 1.00 69.02 N

ATOM 8200 CA PRO A 552 9.076 45.130 16.050 1.00 70.16 C

ATOM 8202 CB PRO A 552 9.704 44.221 14.988 1.00 69.01 C

ATOM 8205 CG PRO A 552 9.805 42.977 15.585 1.00 68.43 C

ATOM 8208 CD PRO A 552 10.065 43.179 17.085 1.00 67.57 C

ATOM 8211 C PRO A 552 7.584 45.371 15.794 1.00 72.55 C

ATOM 8212 O PRO A 552 7.216 46.194 14.960 1.00 74.90 O

ATOM 8213 N ASP A 553 6.708 44.702 16.518 1.00 73.65 N

ATOM 8215 CA ASP A 553 5.288 44.960 16.308 1.00 76.41 C

ATOM 8217 CB ASP A 553 4.482 43.789 16.845 1.00 77.64 C

ATOM 8220 CG ASP A 553 4.690 42.533 16.029 1.00 80.59 C

ATOM 8221 ODl ASP A 553 5.877 42.294 15.647 1.00 83.78 O

ATOM 8222 OD2 ASP A 553 3.750 41.737 15.698 1.00 84.59 O

ATOM 8223 C ASP A 553 4.864 46.275 16.990 1.00 77.13 C ATOM 8224 O ASP A 553 4.011 47.012 16.498 1.00 79.38 O

ATOM 8225 N ASN A 554 5.493 46.576 18.117 1.00 75.22 N

ATOM 8227 CA ASN A 554 5.081 47.687 18.953 1.00 75.56 C

ATOM 8229 CB ASN A 554 5.296 47.312 20.423 1.00 75.01 C

ATOM 8232 CG ASN A 554 4.457 46.113 20.854 1.00 76.66 C

ATOM 8233 ODl ASN A 554 3.321 45.920 20.378 1.00 79.39 O

ATOM 8234 ND2 ASN A 554 5.013 45.299 21.759 1.00 76.10 N

ATOM 8237 C ASN A 554 5.763 49.021 18.653 1.00 74.89 C

ATOM 8238 O ASN A 554 5.884 49.859 19.531 1.00 73.74 O

ATOM 8239 N CYS A 555 6.191 49.225 17.414 1.00 74.76 N

ATOM 8241 CA CYS A 555 6.585 50.553 16.971 1.00 76.15 C

ATOM 8243 CB CYS A 555 7.378 50.459 15.691 1.00 75.87 C

ATOM 8246 SG CYS A 555 8.888 49.525 15.840 1.00 74.07 S

ATOM 8247 C CYS A 555 5.378 51.399 16.664 1.00 79.28 C

ATOM 8248 O CYS A 555 4.303 50.908 16.314 1.00 80.23 O

ATOM 8249 N ILE A 556 5.549 52.690 16.757 1.00 81.45 N

ATOM 8251 CA ILE A 556 4.588 53.558 16.076 1.00 86.21 C

ATOM 8253 CB ILE A 556 4.217 54.775 16.994 1.00 88.59 C

ATOM 8255 CGl ILE A 556 3.285 54.332 18.145 1.00 88.42 C

ATOM 8258 CDl ILE A 556 2.945 55.465 19.180 1.00 90.10 C

ATOM 8262 CG2 ILE A 556 3.656 55.923 16.146 1.00 91.71 C

ATOM 8266 C ILE A 556 5.349 54.028 14.841 1.00 86.58 C

ATOM 8267 O ILE A 556 6.353 54.729 14.990 1.00 89.16 O

ATOM 8268 N GLN A 557 4.994 53.618 13.653 1.00 85.39 N

ATOM 8270 CA GLN A 557 5.882 53.937 12.530 1.00 85.32 C

ATOM 8272 CB GLN A 557 6.184 55.456 12.453 1.00 87.88 C

ATOM 8275 CG GLN A 557 6.910 55.832 11.136 1.00 89.41 C

ATOM 8278 CD GLN A 557 6.557 57.164 10.557 1.00 91.93 C

ATOM 8279 OEl GLN A 557 6.459 58.148 11.270 1.00 95.30 O

ATOM 8280 NE2 GLN A 557 6.423 57.209 9.247 1.00 92.15 N

ATOM 8283 C GLN A 557 7.229 53.165 12.420 1.00 81.67 C

ATOM 8284 O GLN A 557 8.085 53.251 13.261 1.00 80.12 O

ATOM 8285 N CYS A 558 7.428 52.507 11.295 1.00 81.23 N

ATOM 8287 CA CYS A 558 8.641 51.768 11.012 1.00 79.48 C

ATOM 8289 CB CYS A 558 8.296 50.683 10.007 1.00 79.37 C

ATOM 8292 SG CYS A 558 7.573 49.169 10.702 1.00 81.19 S

ATOM 8293 C CYS A 558 9.759 52.580 10.388 1.00 79.80 C

ATOM 8294 O CYS A 558 9.589 53.173 9.377 1.00 81.16 O

ATOM 8295 N ALA A 559 10.950 52.512 10.935 1.00 78.94 N

ATOM 8297 CA ALA A 559 12.079 53.313 10.421 1.00 80.38 C

ATOM 8299 CB ALA A 559 13.371 53.087 11.285 1.00 78.77 C

ATOM 8303 C ALA A 559 12.432 53.046 8.989 1.00 80.70 C

ATOM 8304 O ALA A 559 12.772 53.965^ 8.290 1.00 83.71 O

ATOM 8305 N HIS A 560 12.415 51.785 8.580 1.00 78.83 N

ATOM 8307 CA HIS A 560 13.025 51.377 7.327 1.00 78.93 C

ATOM 8309 CB HIS A 560 14.232 50.473 7.616 1.00 77.41 C

ATOM 8312 CG HIS A 560 15.521 51.202 7.931 1.00 79.72 C

ATOM 8313 NDl HIS A 560 16.068 52.180 7.112 1.00 82.70 N

ATOM 8315 CEl HIS A 560 17.212 52.607 7.631 1.00 84.13 C

ATOM 8317 NE2 HIS A 560 17.429 51.939 8.758 1.00 83.15 N

ATOM 8319 CD2 HIS A 560 16.395 51.050 8.962 1.00 79.11 C

ATOM 8321 C HIS A 560 11.932 50.680 6.503 1.00 78.66 C

ATOM 8322 O HIS A 560 11.189 51.365 5.825 1.00 81.48 O

ATOM 8323 N TYR A 561 11.771 49.354 6.575 1.00 76.45 N

ATOM 8325 CA TYR A 561 10.666 48.684 5.844 1.00 76.16 C

ATOM 8327 CB TYR A 561 11.162 47.651 4.814 1.00 75.26 C

ATOM 8330 CG TYR A 561 12.188 48.263 3.937 1.00 76.43 C

ATOM 8331 CDl TYR A 561 13.544 48.158 4.251 1.00 76.49 C

ATOM 8333 CEl TYR A 561 14.514 48.770 3.507 1.00 77.50 C

ATOM 8335 CZ TYR A 561 14.133 49.520 2.438 1.00 81.83 C

ATOM 8336 OH TYR A 561 15.079 50.155 1.675 1.00 86.33 O

ATOM 8338 CE2 TYR A 561 12.789 49.645 2.097 1.00 82.34 C

ATOM 8340 CD2 TYR A 561 11.824 49.028 2.861 1.00 79.04 C

ATOM 8342 C TYR A 561 9.733 48.040 6.820 1.00 74.68 C

ATOM 8343 O TYR A 561 10.052 47.969 8.013 1.00 72.79 O

ATOM 8344 N ILE A 562 8.576 47.624 6.285 1.00 75.37 N

ATOM 8346 CA ILE A 562 7.533 46.899 7.014 1.00 75.42 C

ATOM 8348 CB ILE A 562 6.207 47.710 7.246 1.00 77.81 C ATOM 8350 CGl ILE A 562 6.473 49.235 7.482 1.00 81.60 C

ATOM 8353 CDl ILE A 562 5.649 50.324 6.529 1.00 83.69 C

ATOM 8357 CG2 ILE A 562 5.419 47.117 8.432 1.00 75.53 C

ATOM 8361 C ILE A 562 7.189 45.624 6.263 1.00 75.08 C

ATOM 8362 O ILE A 562 6.904 45.638 5.077 1.00 75.61 O

ATOM 8363 N ASP A 563 7.225 44.529 7.012 1.00 73.98 N

ATOM 8365 CA ASP A 563 6.927 43.193 6.553 1.00 73.94 C

ATOM 8367 CB ASP A 563 8.170 42.341 6.827 1.00 72.30 C

ATOM 8370 CG ASP A 563 8.107 40.945 6.226 1.00 72.50 C

ATOM 8371 ODl ASP A 563 7.372 40.727 5.229 1.00 70.35 O

ATOM 8372 OD2 ASP A 563 8.822 40.012 6.712 1.00 72.64 O

ATOM 8373 C ASP A 563 5.760 42.742 7.401 1.00 74.39 C

ATOM 8374 O ASP A 563 5.902 42.627 8.612 1.00 73.65 O

ATOM 8375 N GLY A 564 4.600 42.522 6.796 1.00 75.74 N

ATOM 8377 CA GLY A 564 3.414 42.251 7.590 1.00 77.02 C

ATOM 8380 C GLY A 564 3.269 43.192 8.781 1.00 76.38 C

ATOM 8381 O GLY A 564 3.406 44.373 8.626 1.00 75.98 O

ATOM 8382 N PRO A 565 2.992 42.679 9.966 1.00 76.69 N

ATOM 8383 CA PRO A 565 2.937 43.529 11.162 1.00 77.09 C

ATOM 8385 CB PRO A 565 2.388 42.599 12.264 1.00 77.30 C

ATOM 8388 CG PRO A 565 2.710 41.225 11.789 1.00 77.15 C

ATOM 8391 CD PRO A 565 2.673 41.277 10.276 1.00 77.40 C

ATOM 8394 C PRO A 565 4.264 44.083 11.612 1.00 75.13 C

ATOM 8395 O PRO A 565 4.210 45.061 12.315 1.00 76.23 O

ATOM 8396 N HIS A 566 5.389 43.477 11.245 1.00 73.76 N

ATOM 8398 CA HIS A 566 6.707 43.775 11.819 1.00 71.93 C

ATOM 8400 CB HIS A 566 7.618 42.556 11.660 1.00 70.47 C

ATOM 8403 CG HIS A 566 7.029 41.249 12.095 1.00 70.87 C

ATOM 8404 NDl HIS A 566 7.119 40.789 13.387 1.00 71.81 N

ATOM 8406 CEl HIS A 566 6.566 39.590 13.461 1.00 74.18 C

ATOM 8408 NE2 HIS A 566 6.133 39.251 12.260 1.00 73.76 N

ATOM 8410 CD2 HIS A 566 6.430 40.264 11.386 1.00 72.64 C

ATOM 8412 C HIS A 566 7.442 44.879 11.078 1.00 72.22 C

ATOM 8413 O HIS A 566 7.337 44.943 9.859 1.00 74.16 O

ATOM 8414 N CYS A 567 8.246 45.687 11.769 1.00 71.03 N

ATOM 8416 CA CYS A 567 9.234 46.549 11.105 1.00 70.86 C

ATOM 8418 CB CYS A 567 9.604 47.726 11.972 1.00 71.52 C

ATOM 8421 SG CYS A 567 8.241 48.666 12.577 1.00 73.87 S

ATOM 8422 C CYS A 567 10.530 45.832 10.962 1.00 69.04 C

ATOM 8423 O CYS A 567 11.035 45.332 11.937 1.00 68.08 O

ATOM 8424 N VAL A 568 11.128 45.862 9.788 1.00 69.34 N

ATOM 8426 CA VAL A 568 12.431 45.284 9.614 1.00 68.53 C

ATOM 8428 CB VAL A 568 12.355 44.035 8.788 1.00 69.32 C

ATOM 8430 CGl VAL A 568 13.574 42.972 9.226 1.00 69.18 C

ATOM 8434 CG2 VAL A 568 10.953 43.396 8.907 1.00 70.17 C

ATOM 8438 C VAL A 568 13.381 46.205 8.951 1.00 68.70 C

ATOM 8439 O VAL A 568 12.953 47.118 8.287 1.00 71.27 O

ATOM 8440 N LYS A 569 14.673 45.970 9.158 1.00 67.78 N

ATOM 8442 CA LYS A 569 15.725 46.687 8.455 1.00 69.12 C

ATOM 8444 CB LYS A 569 17.100 46.328 9.026 1.00 68.55 C

ATOM 8447 CG LYS A 569 18.246 47.213 8.440 1.00 72.13 C

ATOM 8450 CD LYS A 569 19.587 47.155 9.229 1.00 73.34 C

ATOM 8453 CE LYS A 569 20.258 48.558 9.307 1.00 75.82 C

ATOM 8456 NZ LYS A 569 21.618 48.573 9.964 1.00 77.31 N

ATOM 8460 C LYS A 569 15.732 46.425 6.945 1.00 70.04 C

ATOM 8461 O LYS A 569 16.006 47.328 6.144 1.00 71.03 O

ATOM 8462 N THR A 570 15.498 45.170 6.573 1.00 69.61 N

ATOM 8464 CA THR A 570 15.401 44.774 5.179 1.00 70.80 C

ATOM 8466 CB THR A 570 16.551 43.874 4.758 1.00 70.64 C

ATOM 8468 OGl THR A 570 17.678 44.132 5.574 1.00 69.69 O

ATOM 8470 CG2 THR A 570 17.028 44.225 3.290 1.00 73.62 C

ATOM 8474 C THR A 570 14.147 43.992 4.941 1.00 71.10 C

ATOM 8475 O THR A 570 13.566 43.417 5.860 1.00 70.34 O

ATOM 8476 N CYS A 571 13.727 43.956 3.684 1.00 72.17 N

ATOM 8478 CA CYS A 571 12.740 42.992 3.308 1.00 72.52 C

ATOM 8480 CB CYS A 571 12.089 43.404 2.008 1.00 74.33 C

ATOM 8483 SG CYS A 571 10.724 44.604 2.195 1.00 78.47 S

ATOM 8484 C CYS A 571 13.468 41.631 3.216 1.00 71.56 C ATOM 8485 O CYS A 571 14.624 41.563 2.831 1.00 71.33 O

ATOM 8486 N PRO A 572 12.807 40.570 3.634 1.00 71.21 N

ATOM 8487 CA PRO A 572 13.365 39.208 3.601 1.00 70.85 C

ATOM 8489 CB PRO A 572 12.172 38.339 3.923 1.00 71.07 C

ATOM 8492 CG PRO A 572 11.307 39.225 4.741 1.00 72.16 C

ATOM 8495 CD PRO A 572 11.470 40.617 4.231 1.00 71.58 C

ATOM 8498 C PRO A 572 13.861 38.806 2.253 1.00 71.37 C

ATOM 8499 O PRO A 572 13.118 38.873 1.309 1.00 71.71 O

ATOM 8500 N ALA A 573 15.091 38.332 2.192 1.00 71.59 N

ATOM 8502 CA ALA A 573 15.743 37.986 0.933 1.00 72.60 C

ATOM 8504 CB ALA A 573 16.655 39.103 0.532 1.00 72.49 C

ATOM 8508 C ALA A 573 16.537 36.667 1.074 1.00 72.93 C

ATOM 8509 O ALA A 573 17.586 36.608 1.717 1.00 73.24 O

ATOM 8510 N GLY A 574 16.044 35.603 0.472 1.00 73.55 N

ATOM 8512 CA GLY A 574 16.781 34.355 0.481 1.00 75.15 C

ATOM 8515 C GLY A 574 16.810 33.712 1.853 1.00 74.56 C

ATOM 8516 O GLY A 574 17.826 33.607 2.501 1.00 74.55 O

ATOM 8517 N VAL A 575 15.638 33.301 2.271 1.00 74.53 N

ATOM 8519 CA VAL A 575 15.376 32.861 3.612 1.00 74.16 C

ATOM 8521 CB VAL A 575 14.468 33.930 4.276 1.00 72.51 C

ATOM 8523 CGl VAL A 575 13.634 33.376 5.319 1.00 73.47 C

ATOM 8527 CG2 VAL A 575 15.322 34.978 4.860 1.00 70.07 C

ATOM 8531 C VAL A 575 14.734 31.494 3.412 1.00 75.88 C

ATOM 8532 O VAL A 575 14.015 31.284 2.455 1.00 76.15 O

ATOM 8533 N MET A 576 15.001 30.517 4.243 1.00 77.05 N

ATOM 8535 CA MET A 576 14.451 29.252 3.827 1.00 79.91 C

ATOM 8537 CB MET A 576 15.111 28.104 4.533 1.00 81.42 C

ATOM 8540 CG MET A 576 14.645 26.801 3.936 1.00 85.73 C

ATOM 8543 SD MET A 576 14.960 26.651 2.151 1.00 89.21 S

ATOM 8544 CE MET A 576 16.879 26.184 2.371 1.00 90.57 C

ATOM 8548 C MET A 576 12.921 29.212 3.989 1.00 80.55 C

ATOM 8549 O MET A 576 12.415 29.721 4.978 1.00 79.42 O

ATOM 8550 N GLY A 577 12.218 28.602 3.012 1.00 82.68 N

ATOM 8552 CA GLY A 577 10.765 28.366 3.050 1.00 84.07 C

ATOM 8555 C GLY A 577 10.277 26.939 2.725 1.00 87.30 C

ATOM 8556 O GLY A 577 11.075 25.988 2.639 1.00 88.11 O

ATOM 8557 N GLO A 578 8.948 26.807 2.560 1.00 89.19 N

ATOM 8559 CA GLU A 578 8.275 25.574 2.078 1.00 92.83 C

ATOM 8561 CB GLU A 578 6.821 25.929 1.572 1.00 93.63 C

ATOM 8564 CG GLU A 578 5.920 24.741 1.086 1.00 98.88 C

ATOM 8567 CD GLU A 578 5.383 24.801 -0.403 1.00100.15 C

ATOM 8568 OEl GLU A 578 5.169 25.906 -0.965 1.00100.10 O

ATOM 8569 OE2 GLU A 578 5.120 23.730 -1.024 1.00100.27 O

ATOM 8570 C GLU A 578 9.100 24.860 0.942 1.00 94.09 C

ATOM 8571 O GLU A 578 9.703 25.548 0.100 1.00 92.98 O

ATOM 8572 N ASN A 579 9.092 23.509 0.905 1.00 96.70 N

ATOM 8574 CA ASN A 579 9.654 22.694 -0.210 1.00 97.87 C

ATOM 8576 CB ASN A 579 8.673 22.664 -1.431 1.00 98.97 C

ATOM 8579 CG ASN A 579 8.787 21.320 -2.343 1.00103.58 C

ATOM 8580 ODl ASN A 579 9.375 20.292 -1.934 1.00107.20 O

ATOM 8581 ND2 ASN A 579 8.176 21.367 -3.567 1.00102.91 N

ATOM 8584 C ASN A 579 11.088 23.139 -0.599 1.00 95.88 C

ATOM 8585 O ASN A 579 11.436 23.228 -1.761 1.00 95.66 O

ATOM 8586 N ASN A 580 11.921 23.436 0.392 1.00 94.91 N

ATOM 8588 CA ASN A 580 13.261 23.999 0.150 1.00 93.61 C

ATOM 8590 CB ASN A 580 14.272 22.905 -0.271 1.00 96.16 C

ATOM 8593 CG ASN A 580 15.723 23.230 0.188 1.00 96.15 C

ATOM 8594 ODl ASN A 580 16.025 24.371 0.471 1.00 97.19 O

ATOM 8595 ND2 ASN A 580 16.599 22.237 0.248 1.00 96.25 N

ATOM 8598 C ASN A 580 13.325 25.157 -0.873 1.00 91.65 C

ATOM 8599 O ASN A 580 14.368 25.364 -1.497 1.00 91.22 O

ATOM 8600 N THR A 581 12.220 25.893 -1.049 1.00 90.43 N

ATOM 8602 CA THR A 581 12.204 27.090 -1.901 1.00 88.39 C

ATOM 8604 CB THR A 581 10.888 27.209 -2.798 1.00 89.27 C

ATOM 8606 OGl THR A 581 9.764 27.589 -1.994 1.00 89.04 O

ATOM 8608 CG2 THR A 581 10.466 25.857 -3.437 1.00 92.43 C

ATOM 8612 C THR A 581 12.406 28.367 -1.034 1.00 84.96 C

ATOM 8613 O THR A 581 11.544 28.728 -0.221 1.00 83.83 O ATOM 8614 N LEU A 582 13.563 29.011 1.223 1.00 82.72 N ATOM 8616 CA LEU A 582 13.796 30.357 0.742 1.00 79.94 C ATOM 8618 CB LEU A 582 15.097 30.931 -1 288 1.00 79.24 C ATOM 8621 CG LEU A 582 16.381 30.246 -0.893 1.00 80.18 C ATOM 8623 CDl LEU A 582 17.569 31.154 -1.231 1.00 79.77 C ATOM 8627 CD2 LEU A 582 16.366 29.908 0.573 1.00 80.16 C ATOM 8631 C LEU A 582 12.669 31.327 -1.083 1.00 78.75 C ATOM 8632 O LEU A 582 11.920 31.175 -2.062 1.00 78.56 O ATOM 8633 N VAL A 583 12.627 32.351 -0.238 1.00 77.04 N ATOM 8635 CA VAL A 583 11.565 33.320 -0.172 1.00 76.73 C ATOM 8637 CB VAL A 583 10.838 33.269 1.201 1.00 76.17 C ATOM 8639 CGl VAL A 583 9.880 34.449 1.387 1.00 75.25 C ATOM 8643 CG2 VAL A 583 10.076 31.987 1.302 1.00 78.05 C ATOM 8647 C VAL A 583 12.202 34.664 -0.367 1.00 75.52 C ATOM 8648 O VAL A 583 13.122 35.011 0.368 1.00 74.49 O ATOM 8649 N TRP A 584 11.705 35.404 -1.363 1.00 75.92 N ATOM 8651 CA TRP A 584 12.152 36.769 -1.631 1.00 74.96 C ATOM 8653 CB TRP A 584 12.784 36.822 -3.004 1.00 75.84 C ATOM 8656 CG TRP A 584 13.929 35.915 -3.112 1.00 75.22 C ATOM 8657 CDl TRP A 584 13.892 34.622 468 1.00 73.95 C ATOM 8659 NEl TRP A 584 15.156 34.097 430 1.00 72.84 N ATOM 8661 CE2 TRP A 584 16.035 35.062 034 1.00 72.12 C ATOM 8662 CD2 TRP A 584 15.298 36.220 810 1.00 73.54 C ATOM 8663 CE3 TRP A 584 15.972 37.367 -2.379 1.00 73.41 C ATOM 8665 CZ3 TRP A 584 17.340 37.308 -2.209 1.00 74.46 C ATOM 8667 CH2 TRP A 584 18.035 36.127 -2.434 1.00 75.07 C ATOM 8669 CZ2 TRP A 584 17.397 35.002 -2.850 1.00 73.68 C ATOM 8671 C TRP A 584 11.015 37.767 -1.589 1.00 74.89 C ATOM 8672 O TRP A 584 9.889 37.450 -1.907 1.00 75.76 O ATOM 8673 N LYS A 585 11.332 38.992 -1.213 1.00 74.03 N ATOM 8675 CA LYS A 585 10.341 40.037 -1.097 1.00 73.90 C ATOM 8677 CB LYS A 585 9.857 40.189 0.369 1.00 72.96 C ATOM 8680 CG LYS A 585 8.762 39.160 0.785 1.00 72.93 C ATOM 8683 CD LYS A 585 7.912 39.538 2.029 1.00 71.79 C ATOM 8686 CE LYS A 585 6.856 38.458 2.403 1.00 72.28 C ATOM 8689 NZ LYS A 585 6.373 38.409 3.829 1.00 71.42 N ATOM 8693 C LYS A 585 10.947 41.305 -1.619 1.00 73.86 C ATOM 8694 O LYS A 585 12.140 41.474 -1.545 1.00 71.84 O ATOM 8695 N TYR A 586 10.104 42.174 -2.184 1.00 75.89 N ATOM 8697 CA TYR A 586 10.490 43.531 -2.525 1.00 77.16 C ATOM 8699 CB TYR A 586 10.230 43.846 -3.986 1.00 79.32 C ATOM 8702 CG TYR A 586 8.763 43.925 -4.384 1.00 81.59 C ATOM 8703 CDl TYR A 586 8.213 45.101 -4.860 1.00 82.49 C ATOM 8705 CEl TYR A 586 6.859 45.174 -5.239 1.00 86.87 C ATOM 8707 CZ TYR A 586 6.024 44.052 -5.144 1.00 87.16 C ATOM 8708 OH TYR A 586 4.674 44.110 -5.515 1.00 87.71 O ATOM 8710 CE2 TYR A 586 6.560 42.871 -4.672 1.00 85.36 C ATOM 8712 CD2 TYR A 586 7.928 42.812 -4.287 1.00 82.83 C ATOM 8714 C TYR A 586 9.748 44.512 -1.639 1.00 77.86 C ATOM 8715 O TYR A 586 8.764 44.169 -0.970 1.00 76.82 O ATOM 8716 N ALA A 587 10.264 45.735 -1.642 1.00 79.52 N ATOM 8718 CA ALA A 587 9.624 46.881 -1.005 1.00 81.22 C ATOM 8720 CB ALA A 587 10.664 47.718 -0.259 1.00 81.30 C ATOM 8724 C ALA A 587 8.942 47.760 -2.040 1.00 83.87 C ATOM 8725 O ALA A 587 9.587 48.225 -2.966 1.00 85.06 O ATOM 8726 N ASP A 588 7.646 48.003 -1.873 1.00 85.42 N ATOM 8728 CA ASP A 588 6.956 49.034 -2.638 1.00 87.97 C ATOM 8730 CB ASP A 588 5.453 48.660 -2.823 1.00 89.10 C ATOM 8733 CG ASP A 588 4.586 48.846 -1.562 1.00 88.49 C ATOM 8734 ODl ASP A 588 4.972 49.551 -0.614 1.00 88.44 O ATOM 8735 OD2 ASP A 588 3.453 48.328 -1.455 1 00 88.07 O ATOM 8736 C ASP A 588 7.209 50.472 -2.088 1.00 89.91 C ATOM 8737 O ASP A 588 7.973 50.687 -1.122 1.00 88.35 O ATOM 8738 N ALA A 589 6.571 51.439 -2.751 1.00 93.88 N ATOM 8740 CA ALA A 589 6.641 52.881 -2.458 1.00 96.73 C ATOM 8742 CB ALA A 589 5.728 53.626 -3.421 1.00100.11 C ATOM 8746 C ALA A 589 6.276 53.241 -1.005 1.00 96.86 C ATOM 8747 O ALA A 589 6.805 54.223 -0.437 1.00 98.22 O ATOM 8748 N GLY A 590 5.363 52.441 -0.433 1.00 95.88 N

ATOM 8750 CA GLY A 590 4.993 52.493 0.975 1.00 94.90 C

ATOM 8753 C GLY A 590 6.013 51.865 1.906 1.00 91.58 C

ATOM 8754 O GLY A 590 5.808 51.912 3.111 1.00 90.28 O

ATOM 8755 N HIS A 591 7.114 51.337 1.348 1.00 90.22 N

ATOM 8757 CA HIS A 591 8.120 50.545 2.075 1.00 87.77 C

ATOM 8759 CB HIS A 591 8.959 51.439 3.071 1.00 88.45 C

ATOM 8762 CG HIS A 591 9.793 52.510 2.391 1.00 95.05 C

ATOM 8763 NDl HIS A 591 9.493 53.860 2.461 1.00103.48 N

ATOM 8765 CEl HIS A 591 10.363 54.550 1.732 1.00106.24 C

ATOM 8767 NE2 HIS A 591 11.225 53.702 1.194 1.00104.71 N

ATOM 8769 CD2 HIS A 591 10.895 52.423 1.597 1.00 98.92 C

ATOM 8771 C HIS A 591 7.502 49.249 2.733 1.00 84.53 C

ATOM 8772 O HIS A 591 7.962 48.785 3.794 1.00 82.29 O

ATOM 8773 N VAL A 592 6.486 48.675 2.075 1.00 83.76 N

ATOM 8775 CA VAL A 592 5.796 47.466 2.544 1.00 81.76 C

ATOM sm CB VAL A 592 4.215 47.621 2.498 1.00 83.71 C

ATOM 8779 CGl VAL A 592 3.457 46.343 2.905 1.00 81.70 C

ATOM 8783 CG2 VAL A 592 3.769 48.747 3.396 1.00 85.59 C

ATOM 8787 C VAL A 592 6.300 46.291 1.683 1.00 80.26 C

ATOM 8788 O VAL A 592 6.623 46.478 0.512 1.00 80.92 O

ATOM 8789 N CYS A 593 6.362 45.087 2.259 1.00 77.78 N

ATOM 8791 CA CYS A 593 7.075 43.998 1.639 1.00 75.78 C

ATOM 8793 CB CYS A 593 7.847 43.219 2.689 1.00 74.24 C

ATOM 8796 SG CYS A 593 9.221 44.051 3.477 1.00 73.14 S

ATOM 8797 C CYS A 593 6.122 43.052 1.000 1.00 76.03 C

ATOM 8798 O CYS A 593 5.141 42.647 1.620 1.00 75.39 O

ATOM 8799 N HIS A 594 6.431 42.645 -0.221 1.00 76.34 N

ATOM 8801 CA HIS A 594 5.581 41.688 -0.899 1.00 78.01 C

ATOM 8803 CB HIS A 594 4.684 42.369 -1.960 1.00 80.52 C

ATOM 8806 CG HIS A 594 3.723 43.390 -1.407 1.00 81.95 C

ATOM 8807 NDl HIS A 594 2.483 43.052 -0.907 1.00 83.85 N

ATOM 8809 CEl HIS A 594 1.864 44.144 -0.490 1.00 84.93 C

ATOM 8811 NE2 HIS A 594 2.657 45.179 -0.700 1.00 84.02 N

ATOM 8813 CD2 HIS A 594 3.827 44.736 -1.271 1.00 81.36 C

ATOM 8815 C HIS A 594 6.429 40.639 -1.555 1.00 77.43 C

ATOM 8816 O HIS A 594 7.563 40.878 -1.901 1.00 76.36 O

ATOM 8817 N LEU A 595 5.821 39.480 -1.748 1.00 78.64 N

ATOM 8819 CA LEU A 595 6.443 38.324 -2.362 1.00 78.53 C

ATOM 8821 CB LED A 595 5.448 37.149 -2.299 1.00 79.33 C

ATOM 8824 CG LEϋ A 595 5.801 35.797 -1.684 1.00 78.71 C

ATOM 8826 CDl LEU A 595 6.898 35.909 -0.658 1.00 76.77 C

ATOM 8830 CD2 LEU A 595 4.553 35.115 -1.075 1.00 80.22 C

ATOM 8834 C LEU A 595 6.829 38.606 -3.822 1.00 80.06 C

ATOM 8835 O LEU A 595 6.092 39.243 -4.551 1.00 81.01 O

ATOM 8836 N CYS A 596 7.989 38.116 -4.238 1.00 80.39 N

ATOM 8838 CA CYS A 596 8.402 38.165 -5.626 1.00 82.14 C

ATOM 8840 CB CYS A 596 9.907 37.993 -5.745 1.00 81.09 C

ATOM 8843 SG CYS A 596 10.896 39.338 -5.042 1.00 82.20 S

ATOM 8844 C CYS A 596 7.750 37.016 -6.381 1.00 84.23 C

ATOM 8845 O CYS A 596 7.182 36.099 -5.758 1.00 84.81 O

ATOM 8846 N HIS A 597 7.839 37.077 -7.726 1.00 85.98 N

ATOM 8848 CA HIS A 597 7.387 35.991 -8.602 1.00 86.82 C

ATOM 8850 CB HIS A 597 7.815 36.182 -10.084 1.00 88.03 C

ATOM 8853 CG HIS A 597 6.992 35.395 -11.096 1.00 91.55 C

ATOM 8854 NDl HIS A 597 5.695 34.962 -10.863 1.00 94.55 N

ATOM 8856 CEl HIS A 597 5.231 34.335 -11.930 1.00 94.09 C

ATOM 8858 NE2 HIS A 597 6.176 34.338 -12.851 1.00 94.23 N

ATOM 8860 CD2 HIS A 597 7.278 35.008 -12.366 1.00 92.74 C

ATOM 8862 C HIS A 597 8.102 34.818 -8.053 1.00 85.24 C

ATOM 8863 O HIS A 597 9.227 34.973 -7.601 1.00 82.66 O

ATOM 8864 N PRO A 598 7.470 33.649 -8.079 1.00 86.55 N

ATOM 8865 CA PRO A 598 8.206 32.453 -7.664 1.00 86.49 C

ATOM 8867 CB PRO A 598 7.109 31.362 -7.590 1.00 88.23 C

ATOM 8870 CG PRO A 598 5.750 32.113 -7.680 1.00 88.45 C

ATOM 8873 CD PRO A 598 6.076 33.330 -8.490 1.00 87.86 C

ATOM 8876 C PRO A 598 9.361 32.186 -8.678 1.00 86.52 C

ATOM 8877 O PRO A 598 10.423 31.664 -8.294 1.00 85.89 O ATOM 8878 N ASN A 599 9.205 32.641 -9.925 1.00 87.20 N

ATOM 8880 CA ASN A 599 10.270 32.471 -10.943 1.00 87.60 C

ATOM 8882 CB ASN A 599 9.669 32.588 -12.365 1.00 .64 C

ATOM 8885 CG ASN A 599 9.382 31.218 -13.006 1.00 90.07 C

ATOM 8886 ODl ASN A 599 9.676 31.000 -14.178 1.00 92.33 O

ATOM 8887 ND2 ASN A 599 8.799 30.307 -12.241 1.00 88.59 N

ATOM 8890 C ASN A 599 11.524 33.388 -10.788 1.00 86.52 C

ATOM 8891 O ASN A 599 12.405 33.364 -11.639 1.00 87.32 O

ATOM 8892 N CYS A 600 11.599 34.182 -9.712 1.00 84.92 N

ATOM 8894 CA CYS A 600 12.739 35.071 -9.439 1.00 83.58 C

ATOM 8896 CB CYS A 600 12.275 36.331 -8.714 1.00 83.07 C

ATOM 8899 SG CYS A 600 11.574 37.524 -9.848 1.00 86.34 S

ATOM 8900 C CYS A 600 13.757 34.368 -8.590 1.00 82.06 C

ATOM 8901 O CYS A 600 13.838 34.583 -7.390 1.00 80.61 O

ATOM 8902 N THR A 601 14.543 33.532 -9.240 1.00 82.20 N

ATOM 8904 CA THR A 601 15.540 32.732 -8.580 1.00 81.19 C

ATOM 8906 CB THR A 601 16.394 31.985 -9.643 1.00 82.55 C

ATOM 8908 OGl THR A 601 15.581 31.098 -10.403 1.00 81.59 O

ATOM 8910 CG2 THR A 601 17.362 31.047 -8.992 1.00 82.82 C

ATOM 8914 C THR A 601 16.462 33.557 -7..683 1.00 80.12 C

ATOM 8915 O THR A 601 17.064 32.984 -6.775 1.00 80.18 O

ATOM 8916 N TYR A 602 16.626 34.861 -7.927 1.00 79.32 N

ATOM 8918 CA TYR A 602 17.704 35.596 -7.243 1.00 78.82 C

ATOM 8920 CB TYR A 602 18.764 35.995 -8.249 1.00 80.35 C

ATOM 8923 CG TYR A 602 19.511 34.824 -8.832 1.00 81.46 C

ATOM 8924 CDl TYR A 602 19.213 34.362 -10.117 1.00 80.69 C

ATOM 8926 CEl TYR A 602 19.887 33.321 -10.666 1.00 81.66 C

ATOM 8928 CZ TYR A 602 20.870 32.693 -9.952 1.00 82.09 C

ATOM 8929 OH TYR A 602 21.510 31.618 -10.515 1.00 83.96 O

ATOM 8931 CE2 TYR A 602 21.197 33.123 -8.653 1.00 82.70 C

ATOM 8933 CD2 TYR A 602 20.518 34.187 -8.110 1.00 80.31 C

ATOM 8935 C TYR A 602 17.314 36.830 -6.455 1.00 77.63 C

ATOM 8936 O TYR A 602 18.181 37.605 -6.070 1.00 76.60 O

ATOM 8937 N GLY A 603 16.021 36.994 -6.190 1.00 77.48 N

ATOM 8939 CA GLY A 603 15.508 38.166 -5.496 1.00 76.91 C

ATOM 8942 C GLY A 603 15.009 39.185 -6.473 1.00 77.91 C

ATOM 8943 O GLY A 603 15.253 39.045 -7.663 1.00 78.71 O

ATOM 8944 N CYS A 604 14.312 40.206 -5.982 1.00 78.21 N

ATOM 8946 CA CYS A 604 13.738 41.210 -6.882 1.00 79.72 C

ATOM 8948 CB CYS A 604 12.414 40.701 -7, ,464 1.00 80.28 C

ATOM 8951 SG CYS A 604 10.973 40.882 -6.410 1.00 81.56 S

ATOM 8952 C CYS A 604 13.558 42.674 -6.440 1.00 80.19 C

ATOM 8953 O CYS A 604 13.418 43.047 -5.273 1.00 77.79 O

ATOM 8954 N THR A 605 13.512 43.461 -7.504 1.00 83.00 N

ATOM 8956 CA THR A 605 13.431 44.905 -7.548 1.00 84.81 C

ATOM 8958 CB THR A 605 14.006 45.292 -8.941 1.00 87.10 C

ATOM 8960 OGl THR A 605 15.372 45.651 -8.743 1.00 89.61 O

ATOM 8962 CG2 THR A 605 13.337 46.510 -9.660 1.00 90.11 C

ATOM 8966 C THR A 605 11.986 45.326 -7.333 1.00 85.27 C

ATOM 8967 O THR A 605 11.718 46.227 -6.541 1.00 85.22 O

ATOM 8968 N GLY A 606 11.069 44.625 -7.999 1.00 85.73 N

ATOM 8970 CA GLY A 606 9.649 44.898 -7, 928 1.00 86.94 C

ATOM 8973 C GLY A 606 8.783 43.657 124 1.00 86.94 C

ATOM 8974 O GLY A 606 9.223 42.537 -7 925 1.00 85.56 O

ATOM 8975 N PRO A 607 7.534 43.854 -8.515 1.00 89.16 N

ATOM 8976 CA PRO A 607 6.552 42.772 -8.584 1.00 89.64 C

ATOM 8978 CB PRO A 607 5.207 43.521 -8.508 1.00 91.72 C

ATOM 8981 CG PRO A 607 5.467 44.862 -9.127 1.00 93.44 C

ATOM 8984 CD PRO A 607 6.939 45.149 -8.880 1.00 92.13 C

ATOM 8987 C PRO A 607 6.562 41.858 -9.835 1.00 90.94 C

ATOM 8988 O PRO A 607 6.927 42.251 -10.964 1.00 91.02 O

ATOM 8989 N GLY A 608 6.123 40.616 -9.558 1.00 91.39 N

ATOM 8991 CA GLY A 608 5.924 39.533 -10.509 1.00 92.22 C

ATOM 8994 C GLY A 608 6.989 39.311 -11.589 1.00 92.72 C

ATOM 8995 O GLY A 608 8.175 39.081 -11.362 1.00 91.98 O

ATOM 8996 N LEU A 609 6.506 39.353 -12.807 1.00 94.71 N

ATOM 8998 CA LEU A 609 7.270 39.067 -14.030 1.00 95.05 C

ATOM 9000 CB LEU A 609 6.311 39.435 -15.240 1.00 97.40 C ATOM 9003 CG LEU A 609 4.763 39.599 -14.971 1.00 97.53 C

ATOM 9005 CDl LEU A 609 4.034 40.291 -16.098 1.00 99.87 C

ATOM 9009 CD2 LEU A 609 4.038 38.239 -14.601 1.00 96.75 C

ATOM 9013 C LEU A 609 8.667 39.823 -14.097 1.00 94.70 C

ATOM 9014 O LEU A 609 9.722 39.184 -14.227 1.00 92.65 O

ATOM 9015 N ALA A 610 8.610 41.172 -13.954 1.00 96.08 N

ATOM 9017 CA ALA A 610 9.684 42.152 -14.257 1.00 96.49 C

ATOM 9019 CB ALA A 610 9.147 43.190 -15.238 1.00 98.58 C

ATOM 9023 C ALA A 610 10.302 42.887 -13.030 1.00 95.94 C

ATOM 9024 O ALA A 610 10.840 43.987 -13.157 1.00 97.11 O

ATOM 9025 N GLY A 611 10.220 42.304 -11.844 1.00 94.30 N

ATOM 9027 CA GLY A 611 11.240 42.583 -10.848 1.00 93.78 C

ATOM 9030 C GLY A 611 12.516 41.826 -11.256 1.00 94.52 C

ATOM 9031 O GLY A 611 13.637 42.114 -10.819 1.00 93.76 O

ATOM 9032 N CYS A 612 12.314 40.804 -12.087 1.00 96.55 N

ATOM 9034 CA CYS A 612 13.377 40.054 -12.743 1.00 97.90 C

ATOM 9036 CB CYS A 612 12.937 38.613 -12.854 1.00 96.30 C

ATOM 9039 SG CYS A 612 13.031 37.903 -11.240 1.00 90.82 S

ATOM 9040 C CYS A 612 13.582 40.653 -14.140 1.00103.59 C

ATOM 9041 O CYS A 612 12.645 40.648 -14.971 1.00103.99 O

ATOM 9042 N PRO A 613 14.763 41.243 -14.370 1.00108.80 N

ATOM 9043 CA PRO A 613 15.182 41.615 -15.726 1.00114.87 C

ATOM 9045 CB PRO A 613 15.737 43.030 -15.521 1.00114.53 C

ATOM 9048 CG PRO A 613 16.295 42.984 -14.088 1.00110.83 C

ATOM 9051 CD PRO A 613 15.772 41.685 -13.378 1.00107.45 C

ATOM 9054 C PRO A 613 16.262 40.618 -16.273 1.00122.10 C

ATOM 9055 O PRO A 613 16.937 39.895 -15.470 1.00120.24 O

ATOM 9056 N THR A 614 16.391 40.617 -17.621 1.00 47.89 N

ATOM 9058 CA THR A 614 17.198 39.690 -18.467 1.00 53.92 C

ATOM 9060 CB THR A 614 18.247 38.823 -17.659 1.00 55.51 C

ATOM 9062 OGl THR A 614 19.340 39.668 -17.217 1.00 58.77 O

ATOM 9064 CG2 THR A 614 18.907 37.587 -18.539 1.00 57.00 C

ATOM 9068 C THR A 614 16.172 38.798 -19.222 1.00 56.93 C

ATOM 9069 O THR A 614 15.663 39.166 -20.337 1.00 59.17 O

ATOM 9070 OXT THR A 614 15.847 37.720 -18.669 1.00 59.96 O

ATOM 9071 N ASP C 1 33.389 65.342 66.616 1.00 67.77 N

ATOM 9073 CA ASP C 1 33.591 64.060 67.391 1.00 63.04 C

ATOM 9075 CB ASP C 1 34.960 64.034 68.124 1.00 62.38 C

ATOM 9078 CG ASP C 1 36.160 63.729 67.215 1.00 63.30 C

ATOM 9079 ODl ASP C 1 36.329 62.559 66.749 1.00 62.63 O

ATOM 9080 OD2 ASP C 1 37.047 64.606 67.012 1.00 67.29 O

ATOM 9081 C ASP C 1 32.479 63.876 68.450 1.00 60.60 C

ATOM 9082 O ASP C 1 31.963 64.812 68.966 1.00 63.19 O

ATOM 9085 N ILE C 2 32.190 62.647 68.811 1.00 56.23 N

ATOM 9087 CA ILE C 2 31.119 62.338 69.720 1.00 54.21 C

ATOM 9089 CB ILE C 2 30.653 60.829 69.431 1.00 51.58 C

ATOM 9091 CGl ILE C 2 29.523 60.345 70.377 1.00 50.81 C

ATOM 9094 CDl ILE C 2 28.466 59.526 69.644 1.00 49.41 C

ATOM 9098 CG2 ILE C 2 31.758 59.838 69.497 1.00 46.09 C

ATOM 9102 C ILE C 2 31.538 62.546 71.167 1.00 52.71 C

ATOM 9103 O ILE C 2 32.470 61.928 71.639 1.00 50.84 O

ATOM 9104 N LEU C 3 30.821 63.383 71.886 1.00 54.32 N

ATOM 9106 CA LEU C 3 31.006 63.509 73.329 1.00 53.38 C

ATOM 9108 CB LEU C 3 30.547 64.886 73.785 1.00 57.50 C

ATOM 9111 CG LED C 3 31.316 66.005 73.123 1.00 61.79 C

ATOM 9113 CDl LEU C 3 31.128 67.318 73.861 1.00 66.05 C

ATOM 9117 CD2 LEU C 3 32.806 65.586 73.107 1.00 61.67 C

ATOM 9121 C LEU C 3 30.206 62.515 74.091 1.00 50.57 C

ATOM 9122 O LEU C 3 29.205 62.077 73.632 1.00 50.19 O

ATOM 9123 N LEU C 4 30.655 62.200 75.294 1.00 49.48 N

ATOM 9125 CA LEU C 4 29.977 61.272 76.210 1.00 47.62 C

ATOM 9127 CB LEU C 4 30.661 59.899 76.270 1.00 44.26 C

ATOM 9130 CG LEU C 4 30.556 58.903 75.095 1.00 42.54 C

ATOM 9132 CDl LEU C 4 31.192 57.536 75.461 1.00 42.27 C

ATOM 9136 CD2 LEU C 4 29.161 58.642 74.668 1.00 41.09 C

ATOM 9140 C LEU C 4 30.102 61.939 77.564 1.00 49.23 C

ATOM 9141 O LEU C 4 31.203 62.184 78.046 1.00 50.89 O

ATOM 9142 N THR C 5 28.982 62.206 78.193 1.00 50.08 N ATOM 9144 CA THR C 5 28.925 63.052 79.340 00 51.09 C

ATOM 9146 CB THR C 5 28.023 64.197 78.914 00 54.47 C

ATOM 9148 OGl THR C 5 28.669 64.889 77.847 00 54.99 O

ATOM 9150 CG2 THR C 5 27.841 65.257 80.010 00 58.10 C

ATOM 9154 C THR C 5 28.318 62.222 80.455 00 50.26 C

ATOM 9155 O THR C 5 27.173 61.791 80.329 00 52.74 O

ATOM 9156 N GLN C 6 29.054 61.916 81.509 00 48.92 N

ATOM 9158 CA GLN C 6 28.477 61.131 82.612 00 48.41 C

ATOM 9160 CB GLN C 6 29.420 60.029 83.106 1.00 46.13 C

ATOM 9163 CG GLN C 6 29.841 58.951 82.032 1.00 46.01 C

ATOM 9166 CD GLN C 6 30.748 57.811 82.605 1.00 42.83 C

ATOM 9167 OEl GLN C 6 30.341 57.108 83.506 1.00 43.11 O

ATOM 9168 NE2 GLN C 6 31.931 57.649 82.063 1.00 39.15 N

ATOM 9171 C GLN C 6 28.086 62.057 83.776 1.00 51.15 C

ATOM 9172 O GLN C 6 28.575 63.185 83.915 1.00 51.19 O

ATOM 9173 N SER C 7 27.195 61.530 84.618 .00 52.05 N

ATOM 9175 CA SER C 7 26.399 62.344 85.524 .00 55.11 C

ATOM 9177 CB SER C 7 25.240 62.929 84.689 .00 57.59 C

ATOM 9180 OG SER C 7 25.571 64.267 84.306 .00 63.19 O

ATOM 9182 C SER C 7 25.843 61.474 86.652 .00 54.25 C

ATOM 9183 O SER C 7 25.344 60.419 86.357 .00 53.75 O

ATOM 9184 N PRO C 8 25.896 61.871 87.925 .00 55.03 N

ATOM 9185 CA PRO C 8 26.657 63.025 88.411 .00 56.11 C

ATOM 9187 CB PRO C 8 26.204 63.135 89.865 .00 57.98 C

ATOM 9190 CG PRO C 8 25.667 61.770 90.233 .00 56.40 C

ATOM 9193 CD PRO C 8 25.101 61.220 88.994 .00 55.40 C

ATOM 9196 C PRO C 8 28.134 62.756 88.412 .00 54.47 C

ATOM 9197 O PRO C 8 28.565 61.631 88.075 .00 52.22 O

ATOM 9198 N VAL C 9 28.908 63.726 88.859 .00 55.53 N

ATOM 9200 CA VAL C 9 30.311 63.456 89.017 .00 55.24 C

ATOM 9202 CB VAL C 9 31.120 64.738 89.253 .00 58.63 C

ATOM 9204 CGl VAL C 9 32.588 64.416 89.781 .00 58.03 C

ATOM 9208 CG2 VAL C 9 31.166 65.580 87.925 .00 60.37 C

ATOM 9212 C VAL C 9 30.574 62.469 90.150 .00 54.36 C

ATOM 9213 O VAL C 9 31.400 61.558 89.968 .00 53.35 O

ATOM 9214 N ILE C 10 29.927 62.686 91.302 .00 55.71 N

ATOM 9216 CA ILE C 10 29.879 61.722 92.418 .00 55.79 C

ATOM 9218 CB ILE C 10 30.485 62.359 93.690 .00 57.92 C

ATOM 9220 CGl ILE C 10 32.000 62.430 93.602 .00 59.27 C

ATOM 9223 CDl ILE C 10 32.638 63.164 94.791 .00 62.22 C

ATOM 9227 CG2 ILE C 10 30.200 61.541 94.922 .00 58.67 C

ATOM 9231 C ILE C 10 28.393 61.258 92.677 .00 57.07 C

ATOM 9232 O ILE C 10 27.464 62.062 92.664 .00 60.01 O

ATOM 9233 N LEU C 11 28.137 59.983 92.929 .00 55.55 N

ATOM 9235 CA LEU C 11 26.769 59.588 93.190 1.00 56.88 C

ATOM 9237 CB LEU C 11 26.419 58.508 92.202 1.00 54.80 C

ATOM 9240 CG LEU C 11 25.025 57.907 92.195 .00 55.67 C

ATOM 9242 CDl LEU C 11 24.004 58.957 92.115 .00 58.93 C

ATOM 9246 CD2 LEU C 11 24.914 56.991 90.986 .00 54.73 C

ATOM 9250 C LEU C 11 26.688 59.068 94.620 .00 59.06 C

ATOM 9251 O LEU C 11 27.287 58.041 94.901 00 59.11 O

ATOM 9252 N SER C 12 26.023 59.782 95.533 00 61.71 N

ATOM 9254 CA SER C 12 26.005 59.382 96.956 00 63.27 C

ATOM 9256 CB SER C 12 26.214 60.556 97.941 1.00 65.33 C

ATOM 9259 OG SER C 12 27.431 61.153 97.699 1.00 63.03 O

ATOM 9261 C SER C 12 24.681 58.744 97.285 1.00 64.64 C

ATOM 9262 O SER C 12 23.656 59.375 97.191 1.00 66.78 O

ATOM 9263 N VAL C 13 24.750 57.540 97.814 1..0 000 64.40 N

ATOM 9265 CA VAL C 13 23.657 56.618 97.810 1..0 000 65.81 C

ATOM 9267 CB VAL C 13 23.891 55.757 96.586 1..0 000 63.63 C

ATOM 9269 CGl VAL C 13 23.223 54.454 96.715 1..0 000 66.53 C

ATOM 9273 CG2 VAL C 13 23.399 56.484 95.355 1..0 000 64.60 C

ATOM 9277 C VAL C 13 23.712 55.741 99.037 1..0 000 66.60 C

ATOM 9278 O VAL C 13 24.785 55.268 99.380 1..0 000 64.51 O

ATOM 9279 N SER C 14 22.579 55.475 99.680 1. 00 69.64 N

ATOM 9281 CA SER C 14 22.601 54.560 100.836 1. 00 72.09 C

ATOM 9283 CB SER C 14 21.478 54.804 101.839 1. 00 76.76 C

ATOM 9286 OG SER C 14 20.810 56.030 101.609 1.00 79.16 O ATOM 9288 C SER C 14 22.599 53.119 100.356 00 70.71 C

ATOM 9289 O SER C 14 22.149 52.842 99.275 00 68.37 O

ATOM 9290 N PRO C 15 23.152 52.211 101.149 00 72.08 N

ATOM 9291 CA PRO C 15 23.353 50.835 100.735 00 71.76 C

ATOM 9293 CB PRO C 15 24.297 50.294 101.808 00 73.08 C

ATOM 9296 CG PRO C 15 23.978 51.010 102.986 00 76.10 C

ATOM 9299 CD PRO C 15 23.611 52.399 102.530 00 74.92 C

ATOM 9302 C PRO C 15 22.056 50.082 100.765 00 75.00 C

ATOM 9303 O PRO C 15 21.340 50.172 101.721 00 79.23 O

ATOM 9304 N GLY C 16 21.755 49.355 99.712 00 74.43 N

ATOM 9306 CA GLY C 16 20.459 48.743 99.583 00 77.95 C

ATOM 9309 C GLY C 16 19.586 49.408 98.540 00 77.45 C

ATOM 9310 O GLY C 16 18.688 48.741 98.034 00 80.57 O

ATOM 9311 N GLU C 17 19.809 50.673 98.194 00 75.10 N

ATOM 9313 CA GLU C 17 18.992 51.329 97.158 00 74.75 C

ATOM 9315 CB GLU C 17 19.245 52.794 97.143 00 73.81 C

ATOM 9318 CG GLU C 17 18.823 53.497 98.389 00 79.22 C

ATOM 9321 CD GLU C 17 18.808 54.995 98.145 00 79.79 C

ATOM 9322 OEl GLU C 17 19.851 55.616 97.710 00 69.50 O

ATOM 9323 OE2 GLU C 17 17.681 55.505 98.369 00 88.18 O

ATOM 9324 C GLU C 17 19.231 50.930 95.713 00 71.55 C

ATOM 9325 O GLU C 17 20.338 50.462 95.351 00 66.99 O

ATOM 9326 N ALA C 18 18.177 51.167 94.895 00 72.93 N

ATOM 9328 CA ALA C 18 18.342 51.297 93.452 00 69.72 C

ATOM 9330 CB ALA C 18 17.040 51.182 92.640 00 70.80 C

ATOM 9334 C ALA C 18 19.087 52.642 93.212 00 67.33 C

ATOM 9335 O ALA C 18 18.731 53.667 93.755 00 69.28 O

ATOM 9336 N VAL C 19 20.151 52.542 92.424 00 63.49 N

ATOM 9338 CA VAL C 19 21.005 53.594 91.948 00 61.76 C

ATOM 9340 CB VAL C 19 22.441 53.202 92.367 1.00 59.76 C

ATOM 9342 CGl VAL C 19 23.474 54.131 91.797 1.00 57.51 C

ATOM 9346 CG2 VAL C 19 22.521 53.203 93.815 1.00 62.73 C

ATOM 9350 C VAL C 19 21.059 53.596 90.416 1.00 59.34 C

ATOM 9351 O VAL C 19 21.188 52.538 89.832 1.00 59.40 O

ATOM 9352 N SER C 20 21.053 54.764 89.776 1.00 57.96 N

ATOM 9354 CA SER C 20 21.205 54.860 88.333 1.00 55.03 C

ATOM 9356 CB SER C 20 20.027 55.545 87.683 1.00 57.01 C

ATOM 9359 OG SER C 20 18.851 54.897 88.037 00 61.60 O

ATOM 9361 C SER C 20 22.298 55.767 88.035 00 53.24 C

ATOM 9362 O SER C 20 22.254 56.879 88.497 00 54.65 O

ATOM 9363 N PHE C 21 23.257 55.326 87.212 00 50.84 N

ATOM 9365 CA PHE C 21 24.247 56.198 86.595 1.00 48.38 C

ATOM 9367 CB PHE C 21 25.592 55.519 86.453 .00 46.09 C

ATOM 9370 CG PHE C 21 26.047 54.812 87.647 .00 47.07 C

ATOM 9371 CDl PHE C 21 25.631 53.517 87.880 .00 50.09 C

ATOM 9373 CEl PHE C 21 26.041 52.843 88.956 .00 50.03 C

ATOM 9375 CZ PHE C 21 26.878 53.444 89.804 .00 52.96 C

ATOM 9377 CE2 PHE C 21 27.326 54.751 89.576 .00 52.36 C

ATOM 9379 CD2 PHE C 21 26.921 55.399 88.494 .00 49.70 C

ATOM 9381 C PHE C 21 23.797 56.492 85.203 .00 47.89 C

ATOM 9382 O PHE C 21 23.140 55.681 84.629 .00 47.93 O

ATOM 9383 N SER C 22 24.198 57.626 84.646 .00 48.25 N

ATOM 9385 CA SER C 22 23.802 58.025 83.317 .00 49.61 C

ATOM 9387 CB SER C 22 22.694 59.023 83.416 .00 53.37 C

ATOM 9390 OG SER C 22 23.123 59.992 84.294 .00 55.34 O

ATOM 9392 C SER C 22 24.848 58.684 82.473 .00 49.38 C

ATOM 9393 O SER C 22 25.692 59.451 82.980 1.00 51.10 O

ATOM 9394 N CYS C 23 24.693 58.465 81.165 1.00 49.64 N

ATOM 9396 CA CYS C 23 25.639 58.792 80.105 1.00 49.37 C

ATOM 9398 CB CYS C 23 26.354 57.470 79.749 1.00 47.09 C

ATOM 9401 SG CYS C 23 27.565 57.489 78.438 1.00 48.27 S

ATOM 9402 C CYS C 23 24.845 59.312 78.891 1.00 51.54 C

ATOM 9403 O CYS C 23 23.923 58.637 78.433 1.00 51.51 O

ATOM 9404 N ARG C 24 25.162 60.511 78.383 00 53.04 N

ATOM 9406 CA ARG C 24 24.403 61.116 77.240 00 54.66 C

ATOM 9408 CB ARG C 24 23.681 62.434 77.585 00 56.60 C

ATOM 9417 C ARG C 24 25.410 61.393 76.163 00 53.77 C

ATOM 9418 O ARG C 24 26.331 62.193 76.410 1.00 55.68 O ATOM 9419 N ALA C 25 25.276 60.747 75.000 .00 51.76 N

ATOM 9421 CA ALA C 25 26.118 61.042 73.835 .00 50.58 C

ATOM 9423 CB ALA C 25 26.241 59.816 72.982 .00 48.78 C

ATOM 9427 C ALA C 25 25.591 62.193 73.012 .00 53.60 C

ATOM 9428 O ALA C 25 24.412 62.317 72.863 ,00 56.32 O

ATOM 9429 N SER C 26 26.483 63.018 72.497 .00 54.27 N

ATOM 9431 CA SER C 26 26.146 64.197 71.725 .00 59.13 C

ATOM 9433 CB SER C 26 27.425 64.981 71.463 .00 59.86 C

ATOM 9436 OG SER C 26 28.278 64.302 70.552 .00 59.91 O

ATOM 9438 C SER C 26 25.446 63.922 70.377 ,00 61.50 C

ATOM 9439 O SER C 26 24.883 64.864 69.768 .00 66.20 O

ATOM 9440 N GLN C 27 25.529 62.670 69.901 ,00 58.24 N

ATOM 9442 CA GLN C 27 24.827 62.225 68.706 ,00 60.10 C

ATOM 9444 CB GLN C 27 25.688 62.296 67.470 ,00 59.83 C

ATOM 9447 CG GLN C 27 27.081 62.008 67.716 ,00 58.23 C

ATOM 9450 CD GLN C 27 27.918 61.992 66.456 ,00 60.02 C

ATOM 9451 OEl GLN C 27 28.552 62.988 66.171 ,00 62.47 O

ATOM 9452 NE2 GLN C 27 27.924 60.869 65.701 ,00 58.88 N

ATOM 9455 C GLN C 27 24.312 60.827 ,00 57.93 C

ATOM 9456 O GLN C 27 24.902 60.058 69.598 ,00 53.57 O

ATOM 9457 N SER C 28 23.165 60.527 68.271 ,00 61.55 N

ATOM 9459 CA SER C 28 22.408 59.316 68.582 ,00 60.90 C

ATOM 9461 CB SER C 28 20.945 59.423 68.203 1.00 65.18 C

ATOM 9464 OG SER C 28 20.591 58.143 67.697 1.00 66.79 O

ATOM 9466 C SER C 28 23.004 58.084 67.889 1.00 58.36 C

ATOM 9467 O SER C 28 23.256 58.074 66.663 1.00 60.09 O

ATOM 9468 N ILE C 29 23.131 57.029 68.691 1.00 54.91 N

ATOM 9470 CA ILE C 29 24.081 55.941 68.499 1.00 50.73 C

ATOM 9472 CB ILE C 29 24.939 56.025 69.690 1.00 48.76 C

ATOM 9474 CGl ILE C 29 26.204 56.799 69.506 1.00 47.90 C

ATOM 9477 CDl ILE C 29 26.781 56.887 71.020 1.00 46.20 C

ATOM 9481 CG2 ILE C 29 25.406 54.716 70.140 1.00 50.42 C

ATOM 9485 C ILE C 29 23.419 54.538 68.588 1.00 48.53 C

ATOM 9486 O ILE C 29 24.082 53.548 68.607 00 45.78 O

ATOM 9487 N GLY C 30 22.128 54.442 68.772 00 50.20 N

ATOM 9489 CA GLY C 30 21.526 53.158 68.932 00 49.68 C

ATOM 9492 C GLY C 30 21.768 52.584 70.304 00 48.73 C

ATOM 9493 O GLY C 30 21.368 53.115 71.357 00 48.59 O

ATOM 9494 N THR C 31 22.462 51.467 70.275 00 47.96 N

ATOM 9496 CA THR C 31 22.650 50.599 71.412 00 Al .11 C

ATOM 9498 CB THR C 31 22.033 49.252 71.008 00 50.14 C

ATOM 9500 OGl THR C 31 20.656 49.459 70.720 00 56.14 O

ATOM 9502 CG2 THR C 31 21.894 48.337 72.170 00 52.95 C

ATOM 9506 C THR C 31 24.137 50.455 71.595 00 44.48 C

ATOM 9507 O THR C 31 24.637 49.717 72.445 00 42.22 O

ATOM 9508 N ASN C 32 24.885 51.149 70.758 00 43.47 N

ATOM 9510 CA ASN C 32 26.288 50.870 70.721 00 41.11 C

ATOM 9512 CB ASN C 32 26.825 51.306 69.381 00 41.94 C

ATOM 9515 CG ASN C 32 26.386 50.392 68.282 00 43.35 C

ATOM 9516 ODl ASN C 32 26.176 49.129 68.474 00 38.32 O

ATOM 9517 ND2 ASN C 32 26.245 51.004 67.090 00 43.19 N

ATOM 9520 C ASN C 32 27.059 51.545 71.863 00 39.52 C

ATOM 9521 O ASN C 32 27.910 52.433 71.610 00 37.18 O

ATOM 9522 N ILE C 33 26.740 51.112 73.093 00 39.04 N

ATOM 9524 CA ILE C 33 27.444 51.546 74.289 00 38.42 C

ATOM 9526 CB ILE C 33 26.556 52.547 75.003 00 40.72 C

ATOM 9528 CGl ILE C 33 27.221 53.922 74.939 00 43.37 C

ATOM 9531 CDl ILE C 33 26.172 54.854 74.384 00 49.43 C

ATOM 9535 CG2 ILE C 33 26.295 52.247 76.459 00 41.18 C

ATOM 9539 C ILE C 33 27.769 50.425 75.211 00 36.61 C

ATOM 9540 O ILE C 33 26.935 49.529 75.421 00 38.59 O

ATOM 9541 N HIS C 34 28.925 50.499 75.846 00 34.61 N

ATOM 9543 CA HIS C 34 29.162 49.613 76.966 00 34.71 C

ATOM 9545 CB HIS C 34 30.200 48.643 76.574 00 33.97 C

ATOM 9548 CG HIS C 34 30.194 48.311 75.141 00 34.26 C

ATOM 9549 NDl HIS C 34 29.367 47.348 74.630 00 38.92 N

ATOM 9551 CEl HIS C 34 29.607 47.205 73.339 00 38.14 C

ATOM 9553 NE2 HIS C 34 30.540 48.071 72.995 1.00 37.85 N ATOM 9555 CD2 HIS C 34 30.930 48.773 74.108 1.00 34.95 C

ATOM 9557 C HIS C 34 29.522 50.260 78.342 1.00 34.32 C

ATOM 9558 O HIS C 34 29.807 51.432 78.392 1 00 33.64 O

ATOM 9559 N TRP C 35 29.445 49.465 79.426 1 00 34.27 N

ATOM 9561 CA TRP C 35 29.783 49.896 80.759 1 00 34.35 C

ATOM 9563 CB TRP C 35 28.560 49.879 81.571 1 00 35.41 C

ATOM 9566 CG TRP C 35 27.514 50.870 81.176 1 00 38.77 C

ATOM 9567 CDl TRP C 35 26.443 50.635 80.362 1 00 38.77 C

ATOM 9569 NEl TRP C 35 25.680 51.764 80.262 1 00 39.07 N

ATOM 9571 CE2 TRP C 35 26.201 52.740 81.058 1 00 39.78 C

ATOM 9572 CD2 TRP C 35 27.353 52.211 81.662 1 00 37.48 C

ATOM 9573 CE3 TRP C 35 28.075 53.018 82.501 1.00 34.96 C

ATOM 9575 CZ3 TRP C 35 27.628 54.293 82.738 1.00 38.38 C

ATOM 9577 CH2 TRP C 35 26.484 54.789 82.138 1.00 41.25 C

ATOM 9579 CZ2 TRP C 35 25.744 54.022 81.306 00 42.46 C

ATOM 9581 C TRP C 35 30.803 49.082 81.568 00 34.40 C

ATOM 9582 O TRP C 35 30.787 47.871 81.643 00 34.68 O

ATOM 9583 N TYR C 36 31.619 49.809 82.295 1.00 34.73 N

ATOM 9585 CA TYR C 36 32.679 49.273 83.080 1.00 34.84 C

ATOM 9587 CB TYR C 36 33.979 49.790 82.457 .00 33.85 C

ATOM 9590 CG TYR C 36 34.192 49.428 81.000 .00 32.89 C

ATOM 9591 CDl TYR C 36 33.730 50.226 79.935 .00 34.08 C

ATOM 9593 CEl TYR C 36 33.954 49.861 78.569 00 30.47 C

ATOM 9595 CZ TYR C 36 34.628 48.702 78.318 1.00 33.75 C

ATOM 9596 OH TYR C 36 34.972 48.211 77.099 00 32.78 O

ATOM 9598 CE2 TYR C 36 35.081 47.932 79.350 00 36.07 C

ATOM 9600 CD2 TYR C 36 34.855 48.298 80.683 00 34.48 C

ATOM 9602 C TYR C 36 32.638 49.720 84.560 00 36.53 C

ATOM 9603 O TYR C 36 32.184 50.821 84.911 00 37.45 O

ATOM 9604 N GLN C 37 33.181 48.875 85.422 00 37.01 N

ATOM 9606 CA GLN C 37 33.485 49.253 86.776 00 37.99 C

ATOM 9608 CB GLN C 37 32.866 48.245 87.662 00 40.20 C

ATOM 9611 CG GLN C 37 33.024 48.454 89.097 00 43.44 C

ATOM 9614 CD GLN C 37 32.484 47.260 89.850 00 44.50 C

ATOM 9615 OEl GLN C 37 33.095 46.188 89.830 00 41.97 O

ATOM 9616 NE2 GLN C 37 31.341 47.450 90.519 00 45.99 N

ATOM 9619 C GLN C 37 34.971 49.202 86.950 00 38.04 C

ATOM 9620 O GLN C 37 35.576 48.347 86.420 00 37.13 O

ATOM 9621 N GLN C 38 35.532 50.155 87.691 00 39.43 N

ATOM 9623 CA GLN C 38 36.916 50.233 88.006 00 40.11 C

ATOM 9625 CB GLN C 38 37.572 51.356 87.212 00 40.00 C

ATOM 9628 CG GLN C 38 39.138 51.282 87.328 00 41.59 C

ATOM 9631 CD GLN C 38 39.903 52.189 86.386 00 39.71 C

ATOM 9632 OEl GLN C 38 40.911 51.749 85.818 1.00 39.37 O

ATOM 9633 NE2 GLN C 38 39.488 53.456 86.280 1.00 36.17 N

ATOM 9636 C GLN C 38 37.025 50.536 89.490 1.00 42.44 C

ATOM 9637 O GLN C 38 36.535 51.554 89.948 1.00 43.21 O

ATOM 9638 N ARG C 39 37.659 49.658 90.248 1.00 43.81 N

ATOM 9640 CA ARG C 39 37.854 49.916 91.649 1.00 46.09 C

ATOM 9642 CB ARG C 39 37.775 48.654 92.479 .00 47.38 C

ATOM 9645 CG ARG C 39 36.378 48.003 92.388 ,00 47.92 C

ATOM 9648 CD ARG C 39 36.268 46.636 93.005 ,00 49.95 C

ATOM 9651 NE ARG C 39 34.888 46.233 93.235 00 51.18 N

ATOM 9653 CZ ARG C 39 34.457 44.976 93.111 .00 53.33 C

ATOM 9654 NHl ARG C 39 35.280 44.025 92.746 .00 55.36 N

ATOM 9657 NH2 ARG C 39 33.198 44.656 93.305 .00 54.57 N

ATOM 9660 C ARG C 39 39.227 50.474 91.698 .00 48.48 C

ATOM 9661 O ARG C 39 40.076 50.144 90.848 .00 48.36 O

ATOM 9662 N THR C 40 39.446 51.325 92.696 .00 50.49 N

ATOM 9664 CA THR C 40 40.767 51.785 93.054 .00 52.37 C

ATOM 9666 CB THR C 40 40.743 52.104 94.505 .00 54.92 C

ATOM 9668 OGl THR C 40 39.665 53.023 94.716 .00 55.56 O

ATOM 9670 CG2 THR C 40 41.930 52.878 94.904 .00 57.62 C

ATOM 9674 C THR C 40 41.826 50.749 92.731 .00 53.36 C

ATOM 9675 O THR C 40 41.665 49.544 93.025 .00 54.89 O

ATOM 9676 N ASN C 41 42.870 51.206 92.053 .00 52.76 N

ATOM 9678 CA ASN C 41 44.015 50.359 91.762 .00 54.22 C

ATOM 9680 CB ASN C 41 44.688 49.980 93.075 1.00 58.44 C ATOM 9683 CG ASN C 41 45.154 51.230 93.865 1.00 63.41 C

ATOM 9684 ODl ASN C 41 45.183 52.360 93.337 1.00 62.65 O

ATOM 9685 ND2 ASN C 41 45.482 51.031 95.136 1.00 66.15 N

ATOM 9688 C ASN C 41 43.781 49.126 90.892 1.00 51.30 C

ATOM 9689 O ASN C 41 44.628 48.262 90.811 1.00 52.22 O

ATOM 9690 N GLY C 42 42.667 49.105 90.189 1.00 47.41 N

ATOM 9692 CA GLY C 42 42.301 47.978 89.359 1.00 46.02 C

ATOM 9695 C GLY C 42 42.014 48.314 87.911 1.00 43.20 C

ATOM 9696 O GLY C 42 41.863 49.478 87.503 1.00 41.61 O

ATOM 9697 N SER C 43 41.944 47.296 87.084 1.00 42.43 N

ATOM 9699 CA SER C 43 41.710 47.632 85.715 1.00 41.19 C

ATOM 9701 CB SER C 43 42.475 46.773 84.770 1.00 41.96 C

ATOM 9704 OG SER C 43 42.809 45.525 85.299 1.00 46.75 O

ATOM 9706 C SER C 43 40.215 47.594 85.505 1.00 39.79 C

ATOM 9707 O SER C 43 39.487 47.122 86.353 1.00 41.05 O

ATOM 9708 N PRO C 44 39.700 48.223 84.476 1.00 38.34 N

ATOM 9709 CA PRO C 44 38.252 48.202 84.306 1.00 37.29 C

ATOM 9711 CB PRO C 44 37.996 49.170 83.120 1.00 36.21 C

ATOM 9714 CG PRO C 44 39.228 49.834 82.904 1.00 37.50 C

ATOM 9717 CD PRO C 44 40.363 49.045 83.467 1.00 38.27 C

ATOM 9720 C PRO C 44 37.665 46.810 84.093 1.00 35.59 C

ATOM 9721 O PRO C 44 38.311 45.834 83.755 1.00 36.62 O

ATOM 9722 N ARG C 45 36.390 46.753 84.321 1.00 34.62 N

ATOM 9724 CA ARG C 45 35.656 45.514 84.232 1.00 35.68 C

ATOM 9726 CB ARG C 45 35.337 45.068 85.609 1.00 37.79 C

ATOM 9729 CG ARG C 45 34.555 43.888 85.738 1.00 38.23 C

ATOM 9732 CD ARG C 45 34.072 43.791 87.116 1.00 42.83 C

ATOM 9735 NE ARG C 45 33.417 42.512 87.398 1.00 49.92 N

ATOM 9737 CZ ARG C 45 32.649 42.276 88.464 1.00 48.72 C

ATOM 9738 NHl ARG C 45 32.470 43.244 89.332 1.00 42.80 N

ATOM 9741 NH2 ARG C 45 32.061 41.070 88.622 1.00 53.29 N

ATOM 9744 C ARG C 45 34.371 45.749 83.473 1.00 34.81 C

ATOM 9745 O ARG C 45 33.579 46.617 83.770 1.00 34.72 O

ATOM 9746 N LEU C 46 34.174 44.950 82.464 1.00 35.29 N

ATOM 9748 CA LEU C 46 33.028 45.109 81.603 1.00 34.83 C

ATOM 9750 CB LEU C 46 33.294 44.349 80.299 1.00 34.21 C

ATOM 9753 CG LEU C 46 32.122 44.073 79.436 1.00 33.10 C

ATOM 9755 CDl LEU C 46 31.697 45.418 78.882 1.00 34.82 C

ATOM 9759 CD2 LEU C 46 32.515 43.060 78.411 1.00 33.01 C

ATOM 9763 C LEU C 46 31.824 44.529 82.356 1.00 36.54 C

ATOM 9764 O LEU C 46 31.892 43.392 82.806 1.00 38.07 O

ATOM 9765 N LEU C 47 30.782 45.344 82.478 1.00 36.50 N

ATOM 9767 CA LEU C 47 29.501 45.034 83.164 1.00 39.21 C

ATOM 9769 CB LEU C 47 29.061 46.227 83.993 1.00 39.56 C

ATOM 9772 CG LEU C 47 30.000 46.623 85.085 1.00 39.66 C

ATOM 9774 CDl LEU C 47 29.636 47.995 85.413 1.00 40.73 C

ATOM 9778 CD2 LEU C 47 29.808 45.699 86.273 1.00 43.21 C

ATOM 9782 C LEU C 47 28.293 44.773 82.237 1.00 39.13 C

ATOM 9783 O LEU C 47 27.510 43.838 82.443 1.00 41.74 O

ATOM 9784 N ILE C 48 28.172 45.648 81.243 1.00 36.93 N

ATOM 9786 CA ILE C 48 27.142 45.636 80.277 1.00 37.02 C

ATOM 9788 CB ILE C 48 26.072 46.575 80.758 1.00 38.96 C

ATOM 9790 CGl ILE C 48 25.469 45.944 82.022 1.00 42.23 C

ATOM 9793 CDl ILE C 48 24.088 45.977 82.163 1.00 43.44 C

ATOM 9797 CG2 ILE C 48 25.048 46.823 79.629 1.00 41.51 C

ATOM 9801 C ILE C 48 27.663 46.061 78.952 1.00 34.72 C

ATOM 9802 O ILE C 48 28.368 47.060 78.847 1.00 33.27 O

ATOM 9803 N LYS C 49 27.288 45.296 77.927 1.00 35.49 N

ATOM 9805 CA LYS C 49 27.566 45.597 76.514 1.00 33.86 C

ATOM 9807 CB LYS C 49 28.333 44.450 75.916 1.00 33.07 C

ATOM 9810 CG LYS C 49 27.661 43.106 76.022 1.00 38.02 C

ATOM 9813 CD LYS C 49 28.443 42.066 75.280 1.00 39.19 C

ATOM 9816 CE LYS C 49 27.679 41.455 74.125 1.00 40.58 C

ATOM 9819 NZ LYS C 49 28.697 40.846 73.223 1.00 41.24 N

ATOM 9823 C LYS C 49 26.249 45.889 75.720 1.00 34.77 C

ATOM 9824 O LYS C 49 25.183 45.350 75.981 1.00 35.85 O

ATOM 9825 N TYR C 50 26.335 46.780 74.771 1.00 33.83 N

ATOM 9827 CA TYR C 50 25.191 47.100 73.987 1.00 37.51 C ATOM 9829 CB TYR C 50 24.878 46.016 72.959 1.00 38.19 C

ATOM 9832 CG TYR C 50 26.067 45.851 72.028 .00 38.64 C

ATOM 9833 CDl TYR C 50 26.984 44.826 72.216 .00 37.12 C

ATOM 9835 CEl TYR C 50 28.076 44.706 71.409 1.00 33.93 C

ATOM 9837 CZ TYR C 50 28.306 45.624 70.421 .00 32.98 C

ATOM 9838 OH TYR C 50 29.410 45.521 69.616 .00 34.60 O

ATOM 9840 CE2 TYR C 50 27.482 46.665 70.239 .00 34.65 C

ATOM 9842 CD2 TYR C 50 26.363 46.797 71.037 .00 38.98 C

ATOM 9844 C TYR C 50 24.014 47.451 74.872 .00 40.75 C

ATOM 9845 O TYR C 50 22.900 46.896 74.766 .00 42.82 O

ATOM 9846 N ALA C 51 24.282 48.432 75.747 .00 40.74 N

ATOM 9848 CA ALA C 51 23.233 49.188 76.446 .00 41.98 C

ATOM 9850 CB ALA C 51 22.286 49.720 75.487 .00 42.55 C

ATOM 9854 C ALA C 51 22.556 48.363 77.536 .00 43.53 C

ATOM 9855 O ALA C 51 22.440 48.796 78.673 .00 43.80 O

ATOM 9856 N SER C 52 22.203 47.139 77.210 .00 44.89 N

ATOM 9858 CA SER C 52 21.403 46.352 78.108 .00 48.67 C

ATOM 9860 CB SER C 52 19.959 46.450 77.643 .00 52.04 C

ATOM 9863 OG SER C 52 19.845 45.977 76.294 .00 53.55 O

ATOM 9865 C SER C 52 21.783 44.880 78.181 .00 48.92 C

ATOM 9866 O SER C 52 21.086 44.131 78.910 .00 50.69 O

ATOM 9867 N GLU C 53 22.858 44.477 77.491 .00 46.03 N

ATOM 9869 CA GLU C 53 23.166 43.060 77.423 .00 47.67 C

ATOM 9871 CB GLU C 53 23.704 42.543 76.064 .00 46.94 C

ATOM 9874 CG GLU C 53 22.938 42.960 74.829 .00 49.55 C

ATOM 9877 CD GLU C 53 23.501 42.450 73.448 .00 51.85 C

ATOM 9878 OEl GLU C 53 24.687 41.939 73.270 .00 43.43 O

ATOM 9879 OE2 GLU C 53 22.655 42.572 72.483 1.00 57.14 O

ATOM 9880 C GLU C 53 24.150 42.708 78.518 1.00 46.50 C

ATOM 9881 O GLU C 53 25.307 43.167 78.557 1.00 42.83 O

ATOM 9882 N SER C 54 23.689 41.775 79.342 1.00 49.02 N

ATOM 9884 CA SER C 54 24.458 41.304 80.479 1.00 49.21 C

ATOM 9886 CB SER C 54 23.589 40.467 81.346 1.00 52.35 C

ATOM 9889 OG SER C 54 23.295 39.351 80.585 1.00 56.61 O

ATOM 9891 C SER C 54 25.636 40.452 80.034 1.00 46.98 C

ATOM 9892 O SER C 54 25.625 39.895 78.944 1.00 45.39 O

ATOM 9893 N ILE C 55 26.611 40.392 80.941 1.00 45.65 N

ATOM 9895 CA ILE C 55 27.878 39.764 80.739 1.00 44.10 C

ATOM 9897 CB ILE C 55 28.910 40.806 80.912 1.00 40.90 C

ATOM 9899 CGl ILE C 55 29.119 41.482 79.584 1.00 40.37 C

ATOM 9902 CDl ILE C 55 29.086 42.819 79.727 1.00 42.31 C

ATOM 9906 CG2 ILE C 55 30.195 40.224 81.246 1.00 42.13 C

ATOM 9910 C ILE C 55 28.092 38.693 81.748 1.00 47.09 C

ATOM 9911 O ILE C 55 27.684 38.816 82.892 00 49.47 O

ATOM 9912 N SER C 56 28.746 37.611 81.384 00 48.71 N

ATOM 9914 CA SER C 56 28.702 36.538 82.343 00 52.52 C

ATOM 9916 CB SER C 56 28.994 35.174 81.716 1.00 54.74 C

ATOM 9919 OG SER C 56 30.317 34.847 82.071 1.00 57.29 O

ATOM 9921 C SER C 56 29.657 36.960 83.473 1.00 51.73 C

ATOM 9922 O SER C 56 30.536 37.820 83.277 1.00 48.86 O

ATOM 9923 N GLY C 57 29.442 36.398 84.659 1.00 54.10 N

ATOM 9925 CA GLY C 57 30.238 36.705 85.830 1.00 53.98 C

ATOM 9928 C GLY C 57 29.779 37.965 86.529 .00 52.14 C

ATOM 9929 O GLY C 57 30.328 38.382 87.538 .00 52.51 O

ATOM 9930 N ILE C 58 28.756 38.598 86.015 .00 50.75 N

ATOM 9932 CA ILE C 58 28.314 39.794 86.658 .00 49.91 C

ATOM 9934 CB ILE C 58 28.314 40.938 85.671 .00 46.82 C

ATOM 9936 CGl ILE C 58 29.765 41.294 85.421 .00 45.06 C

ATOM 9939 CDl ILE C 58 29.908 41.654 84.172 .00 45.24 C

ATOM 9943 CG2 ILE C 58 27.517 42.240 86.215 .00 45.62 C

ATOM 9947 C ILE C 58 26.990 39.664 87.360 .00 53.05 C

ATOM 9948 O ILE C 58 25.977 39.199 86.799 .00 53.28 O

ATOM 9949 N PRO C 59 27.025 40.124 88.607 .00 54.73 N

ATOM 9950 CA PRO C 59 25.850 40.053 89.461 .00 58.09 C

ATOM 9952 CB PRO C 59 26.262 40.797 90.748 .00 58.25 C

ATOM 9955 CG PRO C 59 27.651 41.330 90.560 .00 55.53 C

ATOM 9958 CD PRO C 59 28.183 40.749 89.287 00 53.29 C

ATOM 9961 C PRO C 59 24.629 40.652 88.749 1.00 57.82 C ATOM 9962 O PRO C 59 24.644 41.654 88.035 1.00 53.30 O

ATOM 9963 N SER C 60 23.562 39.887 88.909 1.00 63.33 N

ATOM 9965 CA SER C 60 22.219 40.188 88.390 1.00 65.73 C

ATOM 9967 CB SER C 60 21.267 39.142 88.972 1.00 71.17 C

ATOM 9970 OG SER C 60 21.740 38.742 90.265 1.00 74.60 O

ATOM 9972 C SER C 60 21.779 41.655 88.744 1.00 64.64 C

ATOM 9973 O SER C 60 21.114 42.343 87.979 1.00 64.25 O

ATOM 9974 N ARG C 61 22.185 42.151 89.894 1.00 64.61 N

ATOM 9976 CA ARG C 61 21.829 43.513 90.261 1.00 63.48 C

ATOM 9978 CB ARG C 61 22.297 43.845 91.663 1.00 64.21 C

ATOM 9981 CG ARG C 61 23.414 43.056 92.181 1.00 63.18 C

ATOM 9984 CD ARG C 61 24.104 43.802 93.236 1.00 63.84 C

ATOM 9987 NE ARG C 61 25.537 43.714 93.099 1.00 61.19 N

ATOM 9989 CZ ARG C 61 26.362 43.963 94.043 1.00 58.51 C

ATOM 9990 NHl ARG C 61 25.979 44.372 95.210 1.00 68.13 N

ATOM 9993 NH2 ARG C 61 27.590 43.835 93.832 1.00 58.31 N

ATOM 9996 C ARG C 61 22.316 44.585 89.309 1.00 59.40 C

ATOM 9997 O ARG C 61 21.757 45.689 89.288 1.00 60.37 O

ATOM 9998 N PHE C 62 23.370 44.295 88.562 1.00 55.68 N

ATOM 10000 CA PHE C 62 23.773 45.184 87.492 1.00 51.73 C

ATOM 10002 CB PHE C 62 25.226 44.908 87.114 1.00 49.74 C

ATOM 10005 CG PHE C 62 26.190 45.398 88.121 1.00 48.14 C

ATOM 10006 CDl PHE C 62 26.773 44.542 89.009 1.00 49.83 C

ATOM 10008 CEl PHE C 62 27.607 44.999 89.940 1.00 50.62 C

ATOM 10010 CZ PHE C 62 27.859 46.353 90.035 1.00 49.05 C

ATOM 10012 CE2 PHE C 62 27.252 47.208 89.173 1.00 46.83 C

ATOM 10014 CD2 PHE C 62 26.440 46.724 88.219 1.00 46.75 C

ATOM 10016 C PHE C 62 22.859 45.064 86.262 1.00 51.66 C

ATOM 10017 O PHE C 62 22.550 43.980 85.814 1.00 52.39 O

ATOM 10018 N SER C 63 22.447 46.200 85.726 1.00 50.26 N

ATOM 10020 CA SER C 63 21.681 46.249 84.502 1.00 51.03 C

ATOM 10022 CB SER C 63 20.242 45.917 84.784 1.00 55.13 C

ATOM 10025 OG SER C 63 19.490 47.066 85.148 1.00 57.69 O

ATOM 10027 C SER C 63 21.835 47.599 83.758 1.00 49.12 C

ATOM 10028 O SER C 63 22.366 48.536 84.265 1.00 47.72 O

ATOM 10029 N GLY C 64 21.405 47.648 82.513 1.00 49.99 N

ATOM 10031 CA GLY C 64 21.517 48.834 81.694 1.00 48.78 C

ATOM 10034 C GLY C 64 20.311 48.920 80.758 1.00 52.32 C

ATOM 10035 O GLY C 64 19.752 47.899 80.330 1.00 54.84 O

ATOM 10036 N SER C 65 19.880 50.152 80.489 1.00 53.63 N

ATOM 10038 CA SER C 65 18.816 50.477 79.546 1.00 56.59 C

ATOM 10040 CB SER C 65 17.528 50.804 80.288 1.00 61.01 C

ATOM 10043 OG SER C 65 17.844 51.826 81.211 1.00 63.48 O

ATOM 10045 C SER C 65 19.200 51.719 78.732 1.00 55.34 C

ATOM 10046 O SER C 65 20.157 52.439 79.066 1.00 53.24 O

ATOM 10047 N GLY C 66 18.429 51.969 77.660 1.00 57.45 N

ATOM 10049 CA GLY C 66 18.670 53.097 76.740 1.00 56.09 C

ATOM 10052 C GLY C 66 18.946 52.775 75.281 1.00 53.82 C

ATOM 10053 O GLY C 66 19.495 51.716 74.976 1.00 50.48 O

ATOM 10054 N SER C 67 18.490 53.659 74.404 1.00 55.01 N

ATOM 10056 CA SER C 67 18.997 53.730 73.072 1.00 55.14 C

ATOM 10058 CB SER C 67 18.520 52.591 72.105 1.00 56.95 C

ATOM 10061 OG SER C 67 17.150 52.540 71.891 1.00 61.53 O

ATOM 10063 C SER C 67 18.766 55.098 72.509 1.00 57.64 C

ATOM 10064 O SER C 67 17.849 55.760 72.887 1.00 61.04 O

ATOM 10065 N GLY C 68 19.654 55.501 71.597 1.00 57.28 N

ATOM 10067 CA GLY C 68 19.701 56.829 71.017 1.00 59.22 C

ATOM 10070 C GLY C 68 20.913 57.529 71.590 1.00 56.57 C

ATOM 10071 O GLY C 68 22.008 57.423 71.141 1.00 53.93 O

ATOM 10072 N THR C 69 20.681 58.136 72.712 1.00 58.48 N

ATOM 10074 CA THR C 69 21.398 59.306 73.137 1.00 59.19 C

ATOM 10076 CB THR C 69 20.645 60.517 72.548 1.00 64.50 C

ATOM 10078 OGl THR C 69 21.537 61.132 71.613 1.00 67.14 O

ATOM 10080 CG2 THR C 69 20.230 61.612 73.564 1.00 66.00 C

ATOM 10084 C THR C 69 21.448 59.347 74.621 1.00 57.98 C

ATOM 10085 O THR C 69 22.437 59.751 75.159 1.00 55.59 O

ATOM 10086 N ASP C 70 20.375 58.909 75.272 1.00 60.07 N

ATOM 10088 CA ASP C 70 20.375 58.727 76.714 1.00 60.09 C ATOM 10090 CB ASP C 70 19.133 59.425 77.247 1.00 64.32 C

ATOM 10093 CG ASP C 70 19.158 60.961 76.992 1.00 70.77 C

ATOM 10094 ODl ASP C 70 20.277 61.595 77.042 1.00 67.90 O

ATOM 10095 OD2 ASP C 70 18.069 61.615 IS. llβ 1.00 79.56 O

ATOM 10096 C ASP C 70 20.433 57.271 77.244 1.00 57.20 C

ATOM 10097 O ASP C 70 19.434 56.565 77.157 1.00 61.34 O

ATOM 10098 N PHE C 71 21.564 56.871 77.814 ,00 52.43 N

ATOM 10100 CA PHE C 71 21.775 55.575 78.451 .00 51.08 C

ATOM 10102 CB PHE C 71 23.020 54.922 77.855 ,00 48.63 C

ATOM 10105 CG PHE C 71 23.070 55.028 76.388 ,00 47.77 C

ATOM 10106 CDl PHE C 71 23.558 56.186 75.786 ,00 46.39 C

ATOM 10108 CEl PHE C 71 23.531 56.351 74.450 ,00 47.37 C

ATOM 10110 CZ PHE C 71 23.001 55.340 73.654 .00 50.56 C

ATOM 10112 CE2 PHE C 71 22.502 54.172 74.245 .00 49.84 C

ATOM 10114 CD2 PHE C 71 22.531 54.039 75.620 00 48.19 C

ATOM 10116 C PHE C 71 21.950 55.645 79.988 ,00 50.97 C

ATOM 10117 O PHE C 71 22.106 56.674 80.535 ,00 52.40 O

ATOM 10118 N THR C 72 21.907 54.515 80.672 ,00 50.66 N

ATOM 10120 CA THR C 72 21.602 54.430 82.111 .00 51.41 C

ATOM 10122 CB THR C 72 20.094 54.686 82.394 .00 55.42 C

ATOM 10124 OGl THR C 72 19.880 56.096 82.612 .00 58.52 O

ATOM 10126 CG2 THR C 72 19.663 54.044 83.737 .00 55.85 C

ATOM 10130 C THR C 72 22.009 53.029 82.632 .00 49.89 C

ATOM 10131 O THR C 72 21.515 51.980 82.190 .00 50.33 O

ATOM 10132 N LEU C 73 22.945 53.034 83.554 1.00 48.22 N

ATOM 10134 CA LEO C 73 23.410 51.850 84.229 1.00 47.33 C

ATOM 10136 CB LEU C 73 24.898 52.013 84.360 00 43.98 C

ATOM 10139 CG LEU C 73 25.579 50.891 85.084 00 43.79 C

ATOM 10141 CDl LEU C 73 25.447 49.588 84.285 00 43.27 C

ATOM 10145 CD2 LEU C 73 27.020 51.257 85.309 00 39.29 C

ATOM 10149 C LEU C 73 22.760 51.821 85.616 1.00 50.10 C

ATOM 10150 O LEU C 73 22.792 52.823 86.325 1.00 51.66 O

ATOM 10151 N SER C 74 22.167 50.743 86.071 1.00 51.27 N

ATOM 10153 CA SER C 74 21.730 50.879 87.435 .00 54.82 C

ATOM 10155 CB SER C 74 20.291 51.311 87.436 .00 57.75 C

ATOM 10158 OG SER C 74 19.645 50.362 86.713 .00 60.90 O

ATOM 10160 C SER C 74 21.976 49.663 88.313 ,00 56.29 C

ATOM 10161 O SER C 74 22.286 48.605 87.809 ,00 56.37 O

ATOM 10162 N ILE C 75 21.872 49.823 89.634 1.00 58.41 N

ATOM 10164 CA ILE C 75 22.106 48.720 90.561 1.00 59.78 C

ATOM 10166 CB ILE C 75 23.356 49.038 91.371 1.00 57.98 C

ATOM 10168 CGl ILE C 75 24.460 49.483 90.438 1.00 54.60 C

ATOM 10171 CDl ILE C 75 25.843 49.606 91.120 1 00 55.60 C

ATOM 10175 CG2 ILE C 75 23.802 47.821 92.132 1 00 59.77 C

ATOM 10179 C ILE C 75 20.937 48.621 91.491 1 00 64.00 C

ATOM 10180 O ILE C 75 20.583 49.616 92.011 1 00 65.00 O

ATOM 10181 N ASN C 76 20.325 47.458 91.705 1 00 67.66 N

ATOM 10183 CA ASN C 76 19.433 47.273 92.874 1 00 72.86 C

ATOM 10185 CB ASN C 76 18.573 46.066 92.666 1 00 77.07 C

ATOM 10188 CG ASN C 76 17.770 46.202 91.447 1 00 80.49 C

ATOM 10189 ODl ASN C 76 17.965 47.202 90.704 1 00 80.41 O

ATOM 10190 ND2 ASN C 76 16.849 45.249 91.198 1 00 83.51 N

ATOM 10193 C ASN C 76 20.234 47.037 94.121 1 00 73.25 C

ATOM 10194 O ASN C 76 21.376 46.588 94.067 1 00 71.87 O

ATOM 10195 N SER C 77 19.686 47.302 95.282 1 00 75.89 N

ATOM 10197 CA SER C 77 20.510 47.059 96.480 1 00 76.19 C

ATOM 10199 CB SER C 77 20.179 45.692 97.115 1 00 80.08 C

ATOM 10202 OG SER C 77 21.236 44.803 96.770 1 00 81.82 O

ATOM 10204 C SER C 77 22.056 47.202 96.231 1 00 70.21 C

ATOM 10205 O SER C 77 22.780 46.223 95.964 1 00 66.16 O

ATOM 10206 N VAL C 78 22.515 48.446 96.376 1 00 68.55 N

ATOM 10208 CA VAL C 78 23.958 48.795 96.322 1 00 65.96 C

ATOM 10210 CB VAL C 78 24.263 50.293 96.464 1 00 64.03 C

ATOM 10212 CGl VAL C 78 25.675 50.540 96.047 1 00 59.70 C

ATOM 10216 CG2 VAL C 78 23.367 51.101 95.666 1 00 63.10 C

ATOM 10220 C VAL C 78 24.733 48.220 97.475 1.00 68.31 C

ATOM 10221 O VAL C 78 24.269 48.259 98.604 1.00 70.79 O

ATOM 10222 N GLU C 79 25.939 47.756 97.184 1.00 67.29 N ATOM 10224 CA GLU C 79 26.747 47.109 98.182 1.00 70.49 C

ATOM 10226 CB GLU C 79 27.015 45.646 97.772 1.00 71.59 C

ATOM 10229 CG GLU C 79 27.567 44.817 98.955 1.00 78.33 C

ATOM 10232 CD GLU C 79 27.217 43.318 98.941 1.00 81.18 C

ATOM 10233 OEl GLU C 79 27.474 42.734 97.843 1.00 73.90 O

ATOM 10234 OE2 GLU C 79 26.760 42.776 100.055 1.00 81.77 O

ATOM 10235 C GLU C 79 28.063 47.841 98.381 1.00 69.03 C

ATOM 10236 O GLU C 79 28.525 48.598 97.500 1.00 66.31 O

ATOM 10237 N SER C 80 28.689 47.602 99.539 1.00 71.62 N

ATOM 10239 CA SER C 80 30.037 48.142 99.822 1.00 70.15 C

ATOM 10241 CB SER C 80 30.613 47.569 101.134 1.00 74.08 C

ATOM 10244 OG SER C 80 31.587 46.535 100 904 1.00 74.59 O

ATOM 10246 C SER C 80 30.987 47.854 98.682 1.00 66.56 C

ATOM 10247 O SER C 80 31.837 48.668 98.330 1.00 65.25 O

ATOM 10248 N GLU C 81 30.846 46.681 98.119 1.00 65.84 N

ATOM 10250 CA GLU C 81 31.744 46.272 97.084 1.00 64.00 C

ATOM 10252 CB GLU C 81 31.555 44.781 96.945 1.00 67.28 C

ATOM 10255 CG GLU C 81 32.772 43.977 96.520 1.00 70.30 C

ATOM 10258 CD GLU C 81 32.322 42.601 95.984 1.00 76.21 C

ATOM 10259 OEl GLU C 81 31.393 41.987 96.673 1.00 77.86 O

ATOM 10260 OE2 GLU C 81 32.876 42.177 94.881 1.00 75.85 O

ATOM 10261 C GLU C 81 31.451 47.010 95.746 1.00 59.35 C

ATOM 10262 O GLU C 81 32.154 46.833 94.764 1.00 57.13 O

ATOM 10263 N ASP C 82 30.422 47.851 95.702 1.00 57.91 N

ATOM 10265 CA ASP C 82 30.121 48.600 94.488 1.00 54.01 C

ATOM 10267 CB ASP C 82 28.618 48.743 94.296 1.00 54.53 C

ATOM 10270 CG ASP C 82 27.901 47.367 94.085 1.00 57.28 C

ATOM 10271 ODl ASP C 82 28.609 46.391 93.687 1.00 53.65 O

ATOM 10272 OD2 ASP C 82 26.642 47.201 94.289 1.00 58.60 O

ATOM 10273 C ASP C 82 30.766 49.950 94.511 1.00 52.01 C

ATOM 10274 O ASP C 82 30.626 50.689 93.606 1.00 49.44 O

ATOM 10275 N ILE C 83 31.480 50.285 95.562 1.00 53.49 N

ATOM 10277 CA ILE C 83 32.314 51.486 95.551 1.00 52.54 C

ATOM 10279 CB ILE C 83 32.877 51.678 96.961 1.00 54.86 C

ATOM 10281 CGl ILE C 83 31.810 52.202 97.892 1.00 56.48 C

ATOM 10284 CDl ILE C 83 32.220 52.011 99.307 1.00 59.82 C

ATOM 10288 CG2 ILE C 83 34.042 52.604 96.978 1.00 55.41 C

ATOM 10292 C ILE C 83 33.434 51.354 94.470 1.00 50.29 C

ATOM 10293 O ILE C 83 34.193 50.354 94.456 1.00 49.66 O

ATOM 10294 N ALA C 84 33.528 52.382 93.610 1.00 48.84 N

ATOM 10296 CA ALA C 84 34.175 52.304 92.263 1.00 46.44 C

ATOM 10298 CB ALA C 84 33.829 50.998 91.537 1.00 44.27 C

ATOM 10302 C ALA C 84 33.761 53.452 91.360 1.00 45.36 C

ATOM 10303 O ALA C 84 32.673 53.978 91.469 1.00 46.26 O

ATOM 10304 N ASP C 85 34.621 53.824 90.437 1.00 44.56 N

ATOM 10306 CA ASP C 85 34.175 54.588 89.275 1.00 43.73 C

ATOM 10308 CB ASP C 85 35.354 55.295 88.690 1.00 43.97 C

ATOM 10311 CG ASP C 85 35.925 56.290 89.604 1.00 47.86 C

ATOM 10312 ODl ASP C 85 35.213 57.307 89.833 1.00 51.36 O

ATOM 10313 OD2 ASP C 85 37.066 56.130 90.098 1.00 46.79 O

ATOM 10314 C ASP C 85 33.502 53.735 88.135 1.00 41.60 C

ATOM 10315 O ASP C 85 33.984 52.694 87.751 1.00 40.63 O

ATOM 10316 N TYR C 86 32.394 54.211 87.600 1.00 40.84 N

ATOM 10318 CA TYR C 86 31.741 53.554 86.508 1.00 39.46 C

ATOM 10320 CB TYR C 86 30.278 53.370 86.862 1.00 40.82 C

ATOM 10323 CG TYR C 86 30.128 52.481 88.089 1.00 41.54 C

ATOM 10324 CDl TYR C 86 30.275 52.972 89.390 1.00 40.87 C

ATOM 10326 CEl TYR C 86 30.238 52.105 90.477 1.00 42.12 C

ATOM 10328 CZ TYR C 86 30.045 50.721 90.274 1.00 43.49 C

ATOM 10329 OH TYR C 86 29.967 49.762 91.277 1.00 44.20 O

ATOM 10331 CE2 TYR C 86 29.911 50.233 88.998 1.00 43.68 C

ATOM 10333 CD2 TYR C 86 29.947 51.111 87.922 1 . 00 43 . 03 C

ATOM 10335 C TYR C 86 31.981 54.442 85.282 1 . 00 39 . 22 C

ATOM 10336 O TYR C 86 31.996 55.699 85.428 1 . 00 39 . 82 O

ATOM 10337 N TYR C 87 32.248 53.781 84.121 1 . 00 37 . 23 N

ATOM 10339 CA TYR C 87 32.593 54.411 82.848 1 . 00 35 . 32 C

ATOM 10341 CB TYR C 87 34.068 54.178 82.513 1 . 00 34 . 25 C

ATOM 10344 CG TYR C 87 35.078 54.824 83 . 436 1 . 00 32 . 69 C ATOM 10345 CDl TYR C 87 35.673 54.085 84.435 1.00 34.43 C

ATOM 10347 CEl TYR C 87 36.624 54.622 85.308 1.00 34.35 C

ATOM 10349 CZ TYR C 87 36.944 55.979 85.221 1.00 35.80 C

ATOM 10350 OH TYR C 87 37.860 56.518 86.145 1.00 36.98 O

ATOM 10352 CE2 TYR C 87 36.313 56.765 84.217 1.00 34.38 C

ATOM 10354 CD2 TYR C 87 35.427 56.154 83.317 1.00 32.88 C

ATOM 10356 C TYR C 87 31.659 53.868 81.712 1.00 35.54 C

ATOM 10357 O TYR C 87 31.079 52.769 81.798 1.00 33.51 O

ATOM 10358 N CYS C 88 31.451 54.688 80.674 1.00 36.35 N

ATOM 10360 CA CYS C 88 30.675 54.252 79.500 1.00 36.73 C

ATOM 10362 CB CYS C 88 29.397 55.021 79.326 1.00 38.36 C

ATOM 10365 SG CYS C 88 29.606 56.785 79.010 1.00 45.26 S

ATOM 10366 C CYS C 88 31.526 54.473 78.301 1.00 36.06 C

ATOM 10367 O CYS C 88 32.359 55.383 78.363 1.00 37.61 O

ATOM 10368 N GLN C 89 31.434 53.593 77.291 1.00 34.22 N

ATOM 10370 CA GLN C 89 32.123 53.844 76.047 1.00 35.12 C

ATOM 10372 CB GLN C 89 33.376 52.960 75.808 1.00 34.83 C

ATOM 10375 CG GLN C 89 33.011 51.589 75.387 1.00 35.80 C

ATOM 10378 CD GLN C 89 34.144 50.697 75.122 1.00 32.88 C

ATOM 10379 OEl GLN C 89 35.021 50.995 74.338 1.00 28.59 O

ATOM 10380 NE2 GLN C 89 34.097 49.552 75.751 1.00 34.45 N

ATOM 10383 C GLN C 89 31.178 53.728 74.916 1.00 35.20 C

ATOM 10384 O GLN C 89 30.136 53.113 75.048 1.00 36.60 O

ATOM 10385 N GLN C 90 31.513 54.370 73.812 1.00 35.36 N

ATOM 10387 CA GLN C 90 30.724 54.222 72.614 1.00 35.88 C

ATOM 10389 CB GLN C 90 30.190 55.561 72.034 1.00 37.15 C

ATOM 10392 CG GLN C 90 31.160 56.518 71.509 1.00 38.90 C

ATOM 10395 CD GLN C 90 31.751 56.167 70.178 1.00 39.85 C

ATOM 10396 OEl GLN C 90 31.045 55.686 69.291 1.00 39.79 O

ATOM 10397 NE2 GLN C 90 33.055 56.488 70.000 1.00 36.83 N

ATOM 10400 C GLN C 90 31.541 53.417 71.654 1.00 34.21 C

ATOM 10401 O GLN C 90 32.721 53.427 71.725 1.00 35.03 O

ATOM 10402 N ASN C 91 30.827 52.751 70.783 1.00 35.58 N

ATOM 10404 CA ASN C 91 31.209 51.680 69.873 1.00 35.22 C

ATOM 10406 CB ASN C 91 30.309 50.451 70.175 1.00 34.54 C

ATOM 10409 CG ASN C 91 31.052 49.282 69.987 1.00 34.93 C

ATOM 10410 ODl ASN C 91 32.257 49.468 69.874 1.00 37.10 O

ATOM 10411 ND2 ASN C 91 30.452 48.094 69.806 1.00 34.50 N

ATOM 10414 C ASN C 91 30.932 52.048 68.387 1.00 36.89 C

ATOM 10415 O ASN C 91 31.327 51.330 67.449 1.00 35.22 O

ATOM 10416 N ASN C 92 30.203 53.164 68.223 1.00 37.82 N

ATOM 10418 CA ASN C 92 29.658 53.596 66.975 1.00 39.19 C

ATOM 10420 CB ASN C 92 28.456 54.437 67.328 1.00 42.61 C

ATOM 10423 CG ASN C 92 27.489 54.658 66.206 1.00 42.89 C

ATOM 10424 ODl ASN C 92 27.520 54.082 65.292 1.00 44.19 O

ATOM 10425 ND2 ASN C 92 26.568 55.490 66.411 1.00 57.14 N

ATOM 10428 C ASN C 92 30.602 54.401 66.135 1.00 39.91 C

ATOM 10429 O ASN C 92 30.717 54.126 64.972 1.00 39.51 O

ATOM 10430 N ASN C 93 31.291 55.405 66.676 1.00 40.89 N

ATOM 10432 CA ASN C 93 32.127 56.280 65.792 1.00 43.39 C

ATOM 10434 CB ASN C 93 31.939 57.785 66.086 1.00 45.26 C

ATOM 10437 CG ASN C 93 30.611 58.254 65.777 1.00 45.20 C

ATOM 10438 ODl ASN C 93 29.775 57.526 65.177 1.00 44.43 O

ATOM 10439 ND2 ASN C 93 30.318 59.439 66.265 1.00 49.86 N

ATOM 10442 C ASN C 93 33.573 55.924 65.885 1.00 42.51 C

ATOM 10443 O ASN C 93 33.867 55.305 66.862 1.00 43.58 O

ATOM 10444 N TRP C 94 34.457 56.343 64.958 1.00 43.96 N

ATOM 10446 CA TRP C 94 35.670 55.658 64.819 1.00 43.09 C

ATOM 10448 CB TRP C 94 36.318 55.596 63.431 1.00 45.10 C

ATOM 10451 CG TRP C 94 37.929 55.151 63.579 1.00 41.72 C

ATOM 10452 CDl TRP C 94 38.440 53.861 63.794 1.00 37.65 C

ATOM 10454 NEl TRP C 94 39.800 53.893 63.964 1.00 38.41 N

ATOM 10456 CE2 TRP C 94 40.213 55.197 63.962 1.00 41.29 C

ATOM 10457 CD2 TRP C 94 39.081 56.019 63.735 1.00 42.04 C

ATOM 10458 CE3 TRP C 94 39.264 57.397 63.732 1.00 44.37 C

ATOM 10460 CZ3 TRP C 94 40.504 57.884 63.875 1.00 46.24 C

ATOM 10462 CH2 TRP C 94 41.596 57.059 64.053 1.00 46.26 C

ATOM 10464 CZ2 TRP C 94 41.473 55.715 64 . 076 1 . 00 44 . 06 C ATOM 10466 C TRP C 94 36.842 55.984 65.627 1.00 44.73 C

ATOM 10467 O TRP C 94 37.890 55.418 65.277 1.00 50.14 O

ATOM 10468 N PRO C 95 36.955 56.786 66.611 00 42.69 N

ATOM 10469 CA PRO C 95 37.708 56.193 67.739 00 39.74 C

ATOM 10471 CB PRO C 95 38.606 57.326 68.220 00 40.92 C

ATOM 10474 CG PRO C 95 38.406 58.340 67.337 00 43.30 C

ATOM 10477 CD PRO C 95 37.050 58.218 66.504 00 45.08 C

ATOM 10480 C PRO C 95 36.737 55.730 68.741 00 37.51 C

ATOM 10481 O PRO C 95 35.826 56.513 68.897 00 40.73 O

ATOM 10482 N THR C 96 36.836 54.564 69.340 00 35.57 N

ATOM 10484 CA THR C 96 36.133 54.302 70.597 00 35.67 C

ATOM 10486 CB THR C 96 36.506 52.995 71.300 00 34.47 C

ATOM 10488 OGl THR C 96 36.874 52.031 70.376 1.00 40.36 O

ATOM 10490 CG2 THR C 96 35.298 52.345 71.897 ,00 34.45 C

ATOM 10494 C THR C 96 36.545 55.342 71.633 ,00 37.15 C

ATOM 10495 O THR C 96 37.697 55.771 71.699 ,00 38.19 O

ATOM 10496 N THR C 97 35.597 55.641 72.520 ,00 37.17 N

ATOM 10498 CA THR C 97 35.688 56.759 73.381 .00 37.73 C

ATOM 10500 CB THR C 97 34.989 57.870 72.675 .00 39.59 C

ATOM 10502 OGl THR C 97 35.841 58.260 71.625 .00 39.41 O

ATOM 10504 CG2 THR C 97 34.957 59.110 73.454 00 45.48 C

ATOM 10508 C THR C 97 35.031 56.368 74.658 1.00 36.93 C

ATOM 10509 O THR C 97 34.132 55.590 74.698 1.00 36.08 O

ATOM 10510 N PHE C 98 35.522 56.933 75.731 1.00 38.65 N

ATOM 10512 CA PHE C 98 34.986 56.695 77.041 00 37.72 C

ATOM 10514 CB PHE C 98 36.159 56.124 77.902 00 37.47 C

ATOM 10517 CG PHE C 98 36.606 54.763 77.485 00 34.26 C

ATOM 10518 CDl PHE C 98 37.578 54.609 76.544 00 35.84 C

ATOM 10520 CEl PHE C 98 38.002 53.331 76.187 1.00 34.75 C

ATOM 10522 CZ PHE C 98 37.421 52.229 76.743 ,00 29.78 C

ATOM 10524 CE2 PHE C 98 36.491 52.389 77.668 ,00 29.34 C

ATOM 10526 CD2 PHE C 98 36.090 53.645 78.051 ,00 31.59 C

ATOM 10528 C PHE C 98 34.422 58.060 77.591 ,00 39.16 C

ATOM 10529 O PHE C 98 34.737 59.159 77.062 .00 40.05 O

ATOM 10530 N GLY C 99 33.598 57.951 78.645 .00 38.61 N

ATOM 10532 CA GLY C 99 33.116 59.091 79.423 ,00 40.58 C

ATOM 10535 C GLY C 99 34.047 59.347 80.600 00 40.69 C

ATOM 10536 O GLY C 99 34.881 58.511 80.838 1.00 39.99 O

ATOM 10537 N ALA C 100 33.936 60.467 81.318 1.00 42.29 N

ATOM 10539 CA ALA C 100 34.929 60.800 82.331 1.00 43.08 C

ATOM 10541 CB ALA C 100 34.952 62.200 82.593 .00 45.44 C

ATOM 10545 C ALA C 100 34.704 60.073 83.615 .00 43.15 C

ATOM 10546 O ALA C 100 35.530 60.158 84.533 .00 46.01 O

ATOM 10547 N GLY C 101 33.582 59.386 83.698 .00 42.22 N

ATOM 10549 CA GLY C 101 33.303 58.487 84.799 .00 41.44 C

ATOM 10552 C GLY C 101 32.429 59.141 85.833 .00 42.90 C

ATOM 10553 O GLY C 101 32.196 60.338 85.710 .00 43.82 O

ATOM 10554 N THR C 102 31.927 58.324 86.776 .00 42.89 N

ATOM 10556 CA THR C 102 31.102 58.722 87.925 .00 44.84 C

ATOM 10558 CB THR C 102 29.615 58.489 87.561 .00 45.99 C

ATOM 10560 OGl THR C 102 29.167 59.579 86.758 .00 48.49 O

ATOM 10562 CG2 THR C 102 28.616 58.548 88.759 .00 48.28 C

ATOM 10566 C THR C 102 31.537 57.838 89.083 .00 44.23 C

ATOM 10567 O THR C 102 31.749 56.657 88.885 .00 43.22 O

ATOM 10568 N LYS C 103 31.688 58.393 90.278 .00 45.21 N

ATOM 10570 CA LYS C 103 32.237 57.643 91.412 .00 45.48 C

ATOM 10572 CB LYS C 103 33.267 58.475 92.288 .00 47.73 C

ATOM 10575 CG LYS C 103 34.082 57.608 93.362 .00 48.87 C

ATOM 10578 CD LYS C 103 35.298 58.255 93.982 .00 53.95 C

ATOM 10581 CE LYS C 103 35.376 58.007 95.634 .00 64.04 C

ATOM 10584 NZ LYS C 103 34.907 59.016 96.915 .00 61.58 N

ATOM 10588 C LYS C 103 31.069 57.287 92.237 .00 46.12 C

ATOM 10589 O LYS C 103 30.196 58.112 92.468 .00 48.00 O

ATOM 10590 N LED C 104 31.042 56.098 92.776 .00 46.17 N

ATOM 10592 CA LEϋ C 104 29.904 55.784 93.608 .00 49.29 C

ATOM 10594 CB LEϋ C 104 29.523 54.342 93.380 .00 49.15 C

ATOM 10597 CG LEU C 104 28.282 53.863 94.082 .00 53.47 C

ATOM 10599 CDl LEU C 104 27.166 54.601 93.392 1.00 56.73 C ATOM 10603 CD2 LEU C 104 28.068 52.313 94.003 1.00 54.16 C

ATOM 10607 C LEU C 104 30.351 55.941 94.993 1.00 51.44 C

ATOM 10608 O LEU C 104 31.362 55.356 95.326 1.00 53.07 O

ATOM 10609 N GLU C 105 29.662 56.720 95.796 1.00 53.36 N

ATOM 10611 CA GLU C 105 29.914 56.710 97.228 1.00 56.53 C

ATOM 10613 CB GLU C 105 30.270 58.104 97.697 1.00 58.68 C

ATOM 10616 CG GLU C 105 30.158 58.333 99.212 1.00 63.77 C

ATOM 10619 CD GLU C 105 30.265 59.803 99.573 1.00 68.90 C

ATOM 10620 OEl GLU C 105 29.358 60.563 99.176 1.00 72.30 O

ATOM 10621 OE2 GLU C 105 31.249 60.206 100.245 1.00 72.61 O

ATOM 10622 C GLU C 105 28.705 56.246 98.031 1.00 58.76 C

ATOM 10623 O GLU C 105 27.599 56.744 97.824 1.00 59.09 O

ATOM 10624 N LEU C 106 28.930 55.327 98.977 1.00 60.31 N

ATOM 10626 CA LEU C 106 27.904 54.929 99.963 1.00 62.77 C

ATOM 10628 CB LEU C 106 28.333 53.678 100.722 1.00 64.45 C

ATOM 10631 CG LEU C 106 28.259 52.375 99.937 1.00 64.30 C

ATOM 10633 CDl LEU C 106 28.586 51.154 100.833 1.00 67.13 C

ATOM 10637 CD2 LEU C 106 26.847 52.259 99.368 1.00 66.90 C

ATOM 10641 C LEU C 106 27.715 55.987 100.994 1.00 64.27 C

ATOM 10642 O LEU C 106 28.692 56.430 101.558 1.00 63.86 O

ATOM 10643 N LYS C 107 26.474 56.364 101.274 1.00 65.47 N

ATOM 10645 CA LYS C 107 26.248 57.151 102.447 1.00 68.21 C

ATOM 10647 CB LYS C 107 25.055 58.121 102.387 1.00 70.02 C

ATOM 10650 CG LYS C 107 24.467 58.503 101.031 1.00 69.45 C

ATOM 10653 CD LYS C 107 23.340 59.617 101.174 1.00 75.00 C

ATOM 10656 CE LYS C 107 21.839 59.052 101.327 1.00 80.27 C

ATOM 10659 NZ LYS C 107 21.257 58.305 100.105 1.00 78.29 N

ATOM 10663 C LYS C 107 26.191 56.193 103.612 1.00 70.40 C

ATOM 10664 O LYS C 107 26.242 54.991 103.448 1.00 69.16 O

ATOM 10665 N ARG C 108 26.094 56.784 104.795 1.00 55.67 N

ATOM 10667 CA ARG C 108 26.552 56.234 106.070 1.00 55.57 C

ATOM 10669 CB ARG C 108 28.060 56.047 105.949 1.00 55.68 C

ATOM 10672 CG ARG C 108 28.725 55.336 107.046 1.00 56.83 C

ATOM 10675 CD ARG C 108 29.579 56.238 107.866 1.00 57.77 C

ATOM 10678 NE ARG C 108 29.552 55.864 109.288 1.00 57.84 N

ATOM 10680 CZ ARG C 108 30.316 54.919 109.761 1.00 60.59 C

ATOM 10681 NHl ARG C 108 31.146 54.248 108.965 1.00 62.42 N

ATOM 10684 NH2 ARG C 108 30.258 54.623 111.020 1.00 64.86 N

ATOM 10687 C ARG C 108 26.229 57.307 107.130 1.00 54.10 C

ATOM 10688 O ARG C 108 26.110 58.500 106.783 1.00 52.40 O

ATOM 10689 N THR C 109 26.067 56.911 108.401 1.00 55.56 N

ATOM 10691 CA THR C 109 25.907 57.934 109.458 1.00 56.08 C

ATOM 10693 CB THR C 109 25.537 57.387 110.847 1.00 58.53 C

ATOM 10695 OGl THR C 109 26.528 56.464 111.278 1.00 58.94 O

ATOM 10697 CG2 THR C 109 24.244 56.654 110.836 1.00 60.67 C

ATOM 10701 C THR C 109 27.167 58.773 109.655 1.00 54.85 C

ATOM 10702 O THR C 109 28.294 58.337 109.480 1.00 54.01 O

ATOM 10703 N VAL C 110 26.945 59.997 110.058 1.00 55.32 N

ATOM 10705 CA VAL C 110 28.021 60.900 110.341 1.00 55.05 C

ATOM 10707 CB VAL C 110 27.434 62.253 110.890 1.00 56.58 C

ATOM 10709 CGl VAL C 110 28.528 63.180 111.294 1.00 57.91 C

ATOM 10713 CG2 VAL C 110 26.507 62.970 109.873 1.00 55.27 C

ATOM 10717 C VAL C 110 28.999 60.194 111.343 1.00 56.38 C

ATOM 10718 O VAL C 110 28.608 59.690 112.392 1.00 57.15 O

ATOM 10719 N ALA C 111 30.277 60.109 110.979 1.00 56.38 N

ATOM 10721 CA ALA C 111 31.305 59.519 111.847 1.00 57.80 C

ATOM 10723 CB ALA C 111 31.851 58.283 111.228 1.00 57.81 C

ATOM 10727 C ALA C 111 32.433 60.527 112.064 1.00 57.43 C

ATOM 10728 O ALA C 111 33.114 60.930 111.134 1.00 55.47 O

ATOM 10729 N ALA C 112 32.619 60.918 113.317 1.00 59.73 N

ATOM 10731 CA ALA C 112 33.580 61.947 113.670 1.00 59.71 C

ATOM 10733 CB ALA C 112 33.324 62.564 115.064 1.00 61.97 C

ATOM 10737 C ALA C 112 34.938 61.327 113.593 1.00 59.10 C

ATOM 10738 O ALA C 112 35.109 60.135 113.881 1.00 60.02 O

ATOM 10739 N PRO C 113 35.869 62.147 113.125 1.00 57.92 N

ATOM 10740 CA PRO C 113 37.241 61.752 112.972 1.00 57.27 C

ATOM 10742 CB PRO C 113 37.830 62.929 112.166 1.00 56.41 C

ATOM 10745 CG PRO C 113 37.022 64.097 112.509 1.00 56.68 C ATOM 10748 CD PRO C 113 35.676 63.541 112.663 1.00 57.56 C

ATOM 10751 C PRO C 113 37.884 61.697 114.306 1.00 59.38 C

ATOM 10752 O PRO C 113 37.599 62.541 115.106 1.00 61.02 O

ATOM 10753 N SER C 114 38.761 60.740 114.498 1.00 59.86 N

ATOM 10755 CA SER C 114 39.630 60.699 115.606 1.00 62.67 C

ATOM 10757 CB SER C 114 39.923 59.236 115.876 1.00 64.64 C

ATOM 10760 OG SER C 114 38.718 58.528 116.164 1.00 66.40 O

ATOM 10762 C SER C 114 40.876 61.455 115.164 1.00 62.27 C

ATOM 10763 O SER C 114 41.536 61.049 114.215 1.00 61.52 O

ATOM 10764 N VAL C 115 41.212 62.536 115.849 1.00 64.21 N

ATOM 10766 CA VAL C 115 42.412 63.338 115.568 1.00 64.84 C

ATOM 10768 CB VAL C 115 42.112 64.867 115.740 1.00 66.16 C

ATOM 10770 CGl VAL C 115 43.187 65.745 115.105 1.00 65.30 C

ATOM 10774 CG2 VAL C 115 40.751 65.225 115.112 1.00 65.65 C

ATOM 10778 C VAL C 115 43.656 62.979 116.413 1.00 67.80 C

ATOM 10779 O VAL C 115 43.555 62.609 117.547 1.00 71.74 O

ATOM 10780 N PHE C 116 44.834 63.156 115.822 1.00 67.72 N

ATOM 10782 CA PHE C 116 46.130 62.702 116.329 1.00 69.88 C

ATOM 10784 CB PHE C 116 46.381 61.247 115.944 1.00 69.43 C

ATOM 10787 CG PHE C 116 45.304 60.316 116.387 1.00 69.98 C

ATOM 10788 CDl PHE C 116 44.217 60.065 115.575 1.00 66.04 C

ATOM 10790 CEl PHE C 116 43.240 59.211 115.989 1.00 68.00 C

ATOM 10792 CZ PHE C 116 43.309 58.597 117.221 1.00 71.83 C

ATOM 10794 CE2 PHE C 116 44.367 58.840 118.040 1.00 75.85 C

ATOM 10796 CD2 PHE C 116 45.367 59.710 117.630 1.00 74.09 C

ATOM 10798 C PHE C 116 47.217 63.542 115.687 1.00 69.39 C

ATOM 10799 O PHE C 116 47.290 63.629 114.457 1.00 67.03 O

ATOM 10800 N ILE C 117 48.055 64.175 116.502 1.00 72.96 N

ATOM 10802 CA ILE C 117 49.120 65.045 115.980 1.00 72.96 C

ATOM 10804 CB ILE C 117 49.000 66.482 116.565 1.00 74.87 C

ATOM 10806 CGl ILE C 117 50.181 67.350 116.111 1.00 76.75 C

ATOM 10809 CDl ILE C 117 49.855 68.819 115.887 1.00 77.88 C

ATOM 10813 CG2 ILE C 117 48.837 66.451 118.062 1.00 79.54 C

ATOM 10817 C ILE C 117 50.458 64.376 116.247 1.00 75.27 C

ATOM 10818 O ILE C 117 50.557 63.617 117.210 1.00 79.55 O

ATOM 10819 N PHE C 118 51.457 64.596 115.387 1.00 74.30 N

ATOM 10821 CA PHE C 118 52.774 63.940 115.508 1.00 76.66 C

ATOM 10823 CB PHE C 118 52.929 62.877 114.426 1.00 74.55 C

ATOM 10826 CG PHE C 118 51.971 61.709 114.544 1.00 74.34 C

ATOM 10827 CDl PHE C 118 50.831 61.640 113.735 1.00 73.64 C

ATOM 10829 CEl PHE C 118 49.942 60.536 113.815 1.00 71.90 C

ATOM 10831 CZ PHE C 118 50.239 59.516 114.666 1.00 72.99 C

ATOM 10833 CE2 PHE C 118 51.383 59.572 115.442 1.00 74.93 C

ATOM 10835 CD2 PHE C 118 52.232 60.651 115.391 1.00 74.47 C

ATOM 10837 C PHE C 118 53.975 64.915 115.393 1.00 78.41 C

ATOM 10838 O PHE C 118 54.268 65.444 114.286 1.00 76.97 O

ATOM 10839 N PRO C 119 54.675 65.181 116.500 1.00 82.21 N

ATOM 10840 CA PRO C 119 55.920 65.957 116.393 1.00 84.25 C

ATOM 10842 CB PRO C 119 56.542 65.838 117.779 1.00 88.82 C

ATOM 10845 CG PRO C 119 55.382 65.517 118.696 1.00 89.91 C

ATOM 10848 CD PRO C 119 54.374 64.797 117.892 1.00 85.44 C

ATOM 10851 C PRO C 119 56.828 65.320 115.316 1.00 82.79 C

ATOM 10852 O PRO C 119 56.648 64.125 114.994 1.00 82.06 O

ATOM 10853 N PRO C 120 57.709 66.107 114.711 1.00 82.76 N

ATOM 10854 CA PRO C 120 58.752 65.563 113.838 1.00 82.28 C

ATOM 10856 CB PRO C 120 59.444 66.815 113.282 1.00 82.97 C

ATOM 10859 CG PRO C 120 59.057 67.942 114.183 1.00 85.25 C

ATOM 10862 CD PRO C 120 57.728 67.580 114.747 1.00 84.01 C

ATOM 10865 C PRO C 120 59.749 64.678 114.568 1.00 85.50 C

ATOM 10866 O PRO C 120 60.140 64.963 115.715 1.00 90.03 O

ATOM 10867 N SER C 121 60.184 63.637 113.886 1.00 84.53 N

ATOM 10869 CA SER C 121 61.025 62.639 114.484 1.00 88.74 C

ATOM 10871 CB SER C 121 60.927 61.392 113.675 1.00 87.48 C

ATOM 10874 OG SER C 121 61.718 61.641 112.529 1.00 88.53 O

ATOM 10876 C SER C 121 62.513 63.037 114.538 1.00 92.58 C

ATOM 10877 O SER C 121 62.974 63.943 113.830 1.00 92.02 O

ATOM 10878 N ASP C 122 63.254 62.310 115.374 1.00 96.87 N

ATOM 10880 CA ASP C 122 64.668 62.564 115.636 1.00100.88 C ATOM 10882 CB ASP C 122 65.212 61.403 116.516 1.00106.35 C

ATOM 10885 CG ASP C 122 64.930 61.583 118.022 1.00110.21 C

ATOM 10886 ODl ASP C 122 63.991 62.303 118.397 1.00109.83 O

ATOM 10887 OD2 ASP C 122 65.610 61.032 118.913 1.00115.97 O

ATOM 10888 C ASP C 122 65.523 62.705 114.353 1.00 99.41 C

ATOM 10889 O ASP C 122 65.919 63.808 113.992 1.00 97.33 O

ATOM 10890 N GLU C 123 65.761 61.552 113.698 1.00 99.99 N

ATOM 10892 CA GLD C 123 66.475 61.402 112.414 1.00 99.67 C

ATOM 10894 CB GLU C 123 66.175 60.022 111.737 1.00 98.14 C

ATOM 10901 C GLU C 123 66.137 62.569 111.477 1.00 96.68 C

ATOM 10902 O GLU C 123 67.038 63.239 110.987 1.00 98.14 O

ATOM 10903 N GLN C 124 64.841 62.842 111.273 1.00 93.61 N

ATOM 10905 CA GLN C 124 64.398 63.880 110.305 1.00 90.64 C

ATOM 10907 CB GLN C 124 62.846 63.927 110.138 1.00 86.51 C

ATOM 10910 CG GLN C 124 62.362 64.800 108.958 1.00 82.22 C

ATOM 10913 CD GLN C 124 60.869 65.118 108.916 1.00 78.52 C

ATOM 10914 OEl GLN C 124 60.108 64.980 109.888 1.00 75.18 O

ATOM 10915 NE2 GLN C 124 60.451 65.558 107.759 1.00 77.75 N

ATOM 10918 C GLN C 124 64.956 65.278 110.658 1.00 92.63 C

ATOM 10919 O GLN C 124 65.541 65.966 109.784 1.00 92.86 O

ATOM 10920 N LEU C 125 64.788 65.691 111.917 1.00 94.07 N

ATOM 10922 CA LEU C 125 65.326 66.981 112.331 1.00 96.57 C

ATOM 10924 CB LEU C 125 64.896 67.338 113.755 1.00 98.49 C

ATOM 10927 CG LEU C 125 63.933 68.526 113.913 1.00 97.09 C

ATOM 10929 CDl LEU C 125 62.846 68.157 114.932 1.00 96.51 C

ATOM 10933 CD2 LEU C 125 64.671 69.836 114.312 .00 99.62 C

ATOM 10937 C LEU C 125 66.857 66.986 112.192 .00100.24 C

ATOM 10938 O LEU C 125 67.463 68.054 112.104 .00102.53 O

ATOM 10939 N LYS C 126 67.467 65.794 112.178 .00101.49 N

ATOM 10941 CA LYS C 126 68.902 65.655 111.893 1.00105.04 C

ATOM 10943 CB LYS C 126 69.455 64.271 112.318 1.00107.49 C

ATOM 10950 C LYS C 126 69.171 65.943 110.397 1.00103.41 C

ATOM 10951 O LYS C 126 70.085 66.726 110.076 1.00106.04 O

ATOM 10952 N SER C 127 68.371 65.337 109.510 1.00 99.35 N

ATOM 10954 CA SER C 127 68.423 65.607 108.082 1.00 97.89 C

ATOM 10956 CB SER C 127 67.356 64.775 107.347 1.00 95.15 C

ATOM 10959 OG SER C 127 66.142 65.501 107.072 1.00 92.42 O

ATOM 10961 C SER C 127 68.227 67.087 107.758 1.00 97.29 C

ATOM 10962 O SER C 127 68.571 67.510 106.671 1.00 97.87 O

ATOM 10963 N GLY C 128 67.655 67.860 108.685 1.00 96.84 N

ATOM 10965 CA GLY C 128 67.451 69.292 108.505 1.00 97.37 C

ATOM 10968 C GLY C 128 66.058 69.738 108.039 1.00 94.13 C

ATOM 10969 O GLY C 128 65.832 70.917 107.753 1.00 94.42 O

ATOM 10970 N THR C 129 65.093 68.828 107.976 1.00 91.09 N

ATOM 10972 CA THR C 129 63.711 69.278 107.773 1.00 88.29 C

ATOM 10974 CB THR C 129 63.245 68.917 106.341 1.00 86.24 C

ATOM 10976 OGl THR C 129 64.353 69.086 105.439 1.00 88.83 O

ATOM 10978 CG2 THR C 129 62.258 69.966 105.811 1.00 85.12 C

ATOM 10982 C THR C 129 62.732 68.840 108.882 1.00 86.18 C

ATOM 10983 O THR C 129 63.036 67.960 109.684 1.00 87.16 O

ATOM 10984 N ALA C 130 61.593 69.530 108.955 1.00 84.15 N

ATOM 10986 CA ALA C 130 60.525 69.238 109.908 1.00 81.98 C

ATOM 10988 CB ALA C 130 60.318 70.399 110.827 1.00 84.47 C

ATOM 10992 C ALA C 130 59.244 68.958 109.157 1.00 78.03 C

ATOM 10993 O ALA C 130 58.773 69.810 108.392 1.00 76.36 O

ATOM 10994 N SER C 131 58.708 67.749 109.369 1.00 76.12 N

ATOM 10996 CA SER C 131 57.410 67.320 108.816 1.00 72.65 C

ATOM 10998 CB SER C 131 57.553 66.111 107.877 1.00 70.72 C

ATOM 11001 OG SER C 131 57.712 66.485 106.501 1.00 70.02 O

ATOM 11003 C SER C 131 56.496 66.992 110.011 1.00 72.77 C

ATOM 11004 O SER C 131 56.814 66.125 110.855 1.00 74.28 O

ATOM 11005 N VAL C 132 55.378 67.710 110.105 1.00 71.88 N

ATOM 11007 CA VAL C 132 54.471 67.565 111.239 1.00 72.03 C

ATOM 11009 CB VAL C 132 54.174 68.881 111.954 1.00 73.84 C

ATOM 11011 CGl VAL C 132 53.490 68.605 113.281 1.00 75.05 C

ATOM 11015 CG2 VAL C 132 55.443 69.693 112.128 1.00 77.41 C

ATOM 11019 C VAL C 132 53.191 67.089 110.658 1.00 69.08 C

ATOM 11020 O VAL C 132 52.743 67.657 109.685 1.00 67.17 O ATOM 11021 N VAL C 133 52.591 66.083 111.287 1.00 68.84 N

ATOM 11023 CA VAL C 133 51.465 65.357 110.700 1.00 66.13 C

ATOM 11025 CB VAL C 133 51.861 63.890 110.444 1.00 66.16 C

ATOM 11027 CGl VAL C 133 50.771 63.077 109.757 1.00 62.31 C

ATOM 11031 CG2 VAL C 133 53.162 63.852 109.672 1.00 68.50 C

ATOM 11035 C VAL C 133 50.262 65.317 111.596 1.00 66.14 C

ATOM 11036 O VAL C 133 50.346 65.030 112.772 1.00 68.15 O

ATOM 11037 N CYS C 134 49.125 65.563 110.990 1.00 64.89 N

ATOM 11039 CA CYS C 134 47.844 65.261 111.575 1.00 64.95 C

ATOM 11041 CB CYS C 134 46.938 66.457 111.408 1.00 65.26 C

ATOM 11044 SG CYS C 134 46.037 66.697 112.941 1.00 72.19 S

ATOM 11045 C CYS C 134 47.197 64.094 110.858 1.00 62.06 C

ATOM 11046 O CYS C 134 47.449 63.862 109.674 1.00 61.20 O

ATOM 11047 N LEU C 135 46.337 63.380 111.568 1.00 61.40 N

ATOM 11049 CA LEU C 135 45.617 62.235 111.027 1.00 58.71 C

ATOM 11051 CB LEU C 135 46.183 60.986 111.655 1.00 60.46 C

ATOM 11054 CG LEU C 135 45.430 59.670 111.520 1.00 61.31 C

ATOM 11056 CDl LEU C 135 45.114 59.308 110.103 1.00 60.36 C

ATOM 11060 CD2 LEU C 135 46.276 58.559 112.078 1.00 63.76 C

ATOM 11064 C LEU C 135 44.221 62.435 111.468 1.00 57.46 C

ATOM 11065 O LEU C 135 43.984 62.674 112.610 1.00 58.68 O

ATOM 11066 N LEU C 136 43.282 62.449 110.566 1.00 56.07 N

ATOM 11068 CA LEU C 136 41.871 62.381 110.951 1.00 56.20 C

ATOM 11070 CB LEU C 136 41.019 63.385 110.192 1.00 54.74 C

ATOM 11073 CG LEU C 136 41.477 64.822 109.904 1.00 55.75 C

ATOM 11075 CDl LEU C 136 40.252 65.754 109.846 1.00 56.08 C

ATOM 11079 CD2 LEU C 136 42.517 65.363 110.864 1.00 57.95 C

ATOM 11083 C LEU C 136 41.455 60.970 110.567 1.00 56.76 C

ATOM 11084 O LEU C 136 41.558 60.579 109.377 1.00 54.98 O

ATOM 11085 N ASN C 137 41.010 60.175 111.543 1.00 59.04 N

ATOM 11087 CA ASN C 137 40.813 58.746 111.242 1.00 60.23 C

ATOM 11089 CB ASN C 137 41.551 57.792 112.223 1.00 63.94 C

ATOM 11092 CG ASN C 137 41.899 56.418 111.560 1.00 66.89 C

ATOM 11093 ODl ASN C 137 41.856 56.288 110.338 1.00 70.32 O

ATOM 11094 ND2 ASN C 137 42.199 55.407 112.361 1.00 71.93 N

ATOM 11097 C ASN C 137 39.365 58.402 111.194 1.00 58.92 C

ATOM 11098 O ASN C 137 38.607 58.929 111.965 1.00 59.90 O

ATOM 11099 N ASN C 138 39.015 57.519 110.275 1.00 58.00 N

ATOM 11101 CA ASN C 138 37.670 56.976 110.095 1.00 57.80 C

ATOM 11103 CB ASN C 138 37.502 55.768 110.969 1.00 60.82 C

ATOM 11106 CG ASN C 138 38.594 54.763 110.761 1.00 63.86 C

ATOM 11107 ODl ASN C 138 39.038 54.501 109.625 1.00 64.97 O

ATOM 11108 ND2 ASN C 138 39.057 54.201 111.853 1.00 67.79 N

ATOM 11111 C ASN C 138 36.531 57.965 110.296 1.00 56.57 C

ATOM 11112 O ASN C 138 35.732 57.824 111.235 1.00 57.27 O

ATOM 11113 N PHE C 139 36.479 58.985 109.420 1.00 54.48 N

ATOM 11115 CA PHE C 139 35.331 59.891 109.404 1.00 53.81 C

ATOM 11117 CB PHE C 139 35.790 61.326 109.616 1.00 53.42 C

ATOM 11120 CG PHE C 139 36.608 61.856 108.508 1.00 51.95 C

ATOM 11121 CDl PHE C 139 36.007 62.464 107.425 1.00 50.55 C

ATOM 11123 CEl PHE C 139 36.768 62.941 106.395 1.00 50.36 C

ATOM 11125 CZ PHE C 139 38.144 62.850 106.440 1.00 48.23 C

ATOM 11127 CE2 PHE C 139 38.739 62.256 107.503 1.00 49.74 C

ATOM 11129 CD2 PHE C 139 37.976 61.749 108.536 1.00 50.89 C

ATOM 11131 C PHE C 139 34.416 59.794 108.162 1.00 52.65 C

ATOM 11132 O PHE C 139 34.751 59.186 107.164 1.00 50.71 O

ATOM 11133 N TYR C 140 33.241 60.391 108.281 1.00 52.90 N

ATOM 11135 CA TYR C 140 32.274 60.479 107.190 1.00 53.13 C

ATOM 11137 CB TYR C 140 31.467 59.199 107.034 1.00 54.47 C

ATOM 11140 CG TYR C 140 30.597 59.241 105.814 1.00 55.53 C

ATOM 11141 CDl TYR C 140 31.066 58.769 104.599 1.00 56.84 C

ATOM 11143 CEl TYR C 140 30.306 58.850 103.463 1.00 56.96 C

ATOM 11145 CZ TYR C 140 29.054 59.386 103.533 1.00 58.04 C

ATOM 11146 OH TYR C 140 28.331 59.472 102.372 1.00 60.87 O

ATOM 11148 CE2 TYR C 140 28.565 59.856 104.720 1.00 57.39 C

ATOM 11150 CD2 TYR C 140 29.344 59.792 105.851 1.00 56.47 C

ATOM 11152 C TYR C 140 31.327 61.564 107.646 1.00 53.37 C

ATOM 11153 O TYR C 140 30.973 61.600 108.799 1.00 54.87 O ATOM 11154 N PRO C 141 30.932 62.477 106.799 1.00 52.72 N

ATOM 11155 CA PRO C 141 31.297 62.520 105.408 1.00 52.43 C

ATOM 11157 CB PRO C 141 30.176 63.388 104.835 1.00 53.29 C

ATOM 11160 CG PRO C 141 29.996 64.367 105.828 1.00 53.92 C

ATOM 11163 CD PRO C 141 30.119 63.638 107.168 1.00 53.63 C

ATOM 11166 C PRO C 141 32.700 63.141 105.142 1.00 51.46 C

ATOM 11167 O PRO C 141 33.371 63.582 106.018 1.00 50.16 O

ATOM 11168 N ARG C 142 33.106 63.171 103.880 1.00 52.37 N

ATOM 11170 CA ARG C 142 34.467 63.464 103.538 1.00 52.21 C

ATOM 11172 CB ARG C 142 34.734 63.188 102.077 1.00 53.40 C

ATOM 11175 CG ARG C 142 36.078 63.698 101.630 1.00 56.32 C

ATOM 11178 CD ARG C 142 36.554 63.071 100.360 1.00 60.42 C

ATOM 11181 NE ARG C 142 37.713 63.814 99.826 1.00 62.68 N

ATOM 11183 CZ ARG C 142 38.378 63.446 98.735 1.00 62.72 C

ATOM 11184 NHl ARG C 142 37.965 62.338 98.098 1.00 67.02 N

ATOM 11187 NH2 ARG C 142 39.433 64.150 98.286 1.00 59.04 N

ATOM 11190 C ARG C 142 34.803 64.879 103.799 1.00 52.89 C

ATOM 11191 O ARG C 142 35.994 65.178 104.043 1.00 52.87 O

ATOM 11192 N GLU C 143 33.813 65.776 103.712 1.00 54.26 N

ATOM 11194 CA GLU C 143 34.158 67.175 103.987 1.00 56.18 C

ATOM 11196 CB GLU C 143 33.053 68.169 103.642 1.00 58.86 C

ATOM 11199 CG GLU C 143 33.596 69.598 103.729 1.00 63.26 C

ATOM 11202 CD GLU C 143 32.567 70.696 103.455 1.00 70.77 C

ATOM 11203 OEl GLU C 143 31.399 70.575 103.939 1.00 72.09 O

ATOM 11204 OE2 GLϋ C 143 32.940 71.714 102.782 1.00 74.74 O

ATOM 11205 C GLϋ C 143 34.663 67.386 105.427 1.00 55.52 C

ATOM 11206 O GLU C 143 33.912 67.386 106.409 1.00 55.37 O

ATOM 11207 N ALA C 144 35.975 67.507 105.516 1.00 55.94 N

ATOM 11209 CA ALA C 144 36.665 67.970 106.712 1.00 57.00 C

ATOM 11211 CB ALA C 144 37.587 66.852 107.213 1.00 55.95 C

ATOM 11215 C ALA C 144 37.478 69.253 106.372 1.00 58.66 C

ATOM 11216 O ALA C 144 37.631 69.622 105.214 1.00 59.65 O

ATOM 11217 N LYS C 145 38.038 69.884 107.380 1.00 59.98 N

ATOM 11219 CA LYS C 145 38.880 71.055 107.194 1.00 62.18 C

ATOM 11221 CB LYS C 145 37.975 72.309 107.181 1.00 65.67 C

ATOM 11224 CG LYS C 145 38.627 73.759 107.072 1.00 70.00 C

ATOM 11227 CD LYS C 145 37.728 74.817 107.895 1.00 74.41 C

ATOM 11230 CE LYS C 145 37.394 76.202 107.210 1.00 78.41 C

ATOM 11233 NZ LYS C 145 37.443 76.330 105.690 1.00 76.16 N

ATOM 11237 C LYS C 145 39.948 71.077 108.306 1.00 62.49 C

ATOM 11238 O LYS C 145 39.714 70.784 109.493 1.00 62.13 O

ATOM 11239 N VAL C 146 41.152 71.415 107.909 1.00 63.00 N

ATOM 11241 CA VAL C 146 42.268 71.334 108.824 1.00 63.55 C

ATOM 11243 CB VAL C 146 43.183 70.193 108.431 1.00 61.33 C

ATOM 11245 CGl VAL C 146 44.510 70.267 109.248 1.00 63.03 C

ATOM 11249 CG2 VAL C 146 42.446 68.892 108.609 1.00 58.25 C

ATOM 11253 C VAL C 146 43.060 72.595 108.730 1.00 66.29 C

ATOM 11254 O VAL C 146 43.628 72.875 107.681 1.00 66.84 O

ATOM 11255 N GLN C 147 43.095 73.350 109.817 1.00 68.87 N

ATOM 11257 CA GLN C 147 43.905 74.536 109.882 1.00 72.37 C

ATOM 11259 CB GLN C 147 43.099 75.734 110.396 1.00 76.83 C

ATOM 11262 CG GLN C 147 42.317 76.514 109.337 1.00 77.62 C

ATOM 11265 CD GLN C 147 41.165 77.347 109.930 1.00 80.53 C

ATOM 11266 OEl GLN C 147 41.367 78.499 110.283 1.00 88.62 O

ATOM 11267 NE2 GLN C 147 39.980 76.775 110.015 1.00 74.96 N

ATOM 11270 C GLN C 147 45.058 74.207 110.804 1.00 72.82 C

ATOM 11271 O GLN C 147 44.920 73.510 111.778 1.00 71.65 O

ATOM 11272 N TRP C 148 46.224 74.684 110.443 1.00 74.99 N

ATOM 11274 CA TRP C 148 47.392 74.550 111.287 1.00 76.89 C

ATOM 11276 CB TRP C 148 48.588 74.068 110.465 1.00 74.83 C

ATOM 11279 CG TRP C 148 48.711 72.619 110.138 1.00 70.59 C

ATOM 11280 CDl TRP C 148 48.353 72.042 108.978 1.00 67.59 C

ATOM 11282 NEl TRP C 148 48.676 70.711 108.984 1.00 63.05 N

ATOM 11284 CE2 TRP C 148 49.305 70.418 110.155 1.00 65.79 C

ATOM 11285 CD2 TRP C 148 49.343 71.584 110.905 1.00 69.46 C

ATOM 11286 CE3 TRP C 148 49.938 71.526 112.141 1.00 72.82 C

ATOM 11288 CZ3 TRP C 148 50.457 70.314 112.584 1.00 71.92 C

ATOM 11290 CH2 TRP C 148 50.410 69.202 111.822 1.00 68.74 C ATOM 11292 CZ2 TRP C 148 49.838 69.223 110.603 1.00 67.06 C

ATOM 11294 C TRP C 148 47.705 75.955 111.937 1.00 82.80 C

ATOM 11295 O TRP C 148 47.740 77.001 111.243 1.00 84.38 O

ATOM 11296 N LYS C 149 47.929 75.943 113.262 1.00 85.63 N

ATOM 11298 CA LYS C 149 48.203 77.147 114.050 1.00 91.54 C

ATOM 11300 CB LYS C 149 47.065 77.424 115.063 1.00 94.11 C

ATOM 11303 CG LYS C 149 45.657 77.643 114.457 1.00 92.57 C

ATOM 11306 CD LYS C 149 44.608 77.959 115.522 1.00 95.47 C

ATOM 11309 CE LYS C 149 43.170 77.612 115.088 1.00 93.07 C

ATOM 11312 NZ LYS C 149 42.369 76.679 116.029 1.00 90.06 N

ATOM 11316 C LYS C 149 49.548 76.978 114.773 1.00 93.58 C

ATOM 11317 O LYS C 149 49.876 75.896 115.279 1.00 91.51 O

ATOM 11318 N VAL C 150 50.315 78.062 114.807 1.00 97.73 N

ATOM 11320 CA VAL C 150 51.624 78.061 115.384 1.00100.07 C

ATOM 11322 CB VAL C 150 52.631 78.262 114.275 1.00 99.22 C

ATOM 11324 CGl VAL C 150 54.029 78.444 114.828 1.00104.37 C

ATOM 11328 CG2 VAL C 150 52.601 77.096 113.333 1.00 93.65 C

ATOM 11332 C VAL C 150 51.629 79.233 116.329 1.00107.01 C

ATOM 11333 O VAL C 150 51.874 80.369 115.916 1.00111.28 O

ATOM 11334 N ASP C 151 51.334 78.985 117.600 .00109.29 N

ATOM 11336 CA ASP C 151 51.128 80.083 118.573 .00116.46 C

ATOM 11338 CB ASP C 151 52.361 81.004 118.708 .00121.70 C

ATOM 11341 CG ASP C 151 53.612 80.265 119.111 .00119.58 C

ATOM 11342 ODl ASP C 151 53.619 79.651 120.194 .00118.15 O

ATOM 11343 OD2 ASP C 151 54.640 80.248 118.410 .00116.55 O

ATOM 11344 C ASP C 151 49.927 80.929 118.156 .00118.10 C

ATOM 11345 O ASP C 151 49.762 82.048 118.615 .00124.53 O

ATOM 11346 N ASN C 152 49.106 80.368 117.273 .00112.89 N

ATOM 11348 CA ASN C 152 47.884 80.991 116.737 .00113.81 C

ATOM 11350 CB ASN C 152 46.964 81.550 117.853 .00119.38 C

ATOM 11353 CG ASN C 152 46.467 80.472 118.794 1.00117.08 C

ATOM 11354 ODl ASN C 152 45.498 79.741 118.489 1.00111.65 O

ATOM 11355 ND2 ASN C 152 47.133 80.356 119.948 1.00119.53 N

ATOM 11358 C ASN C 152 48.039 82.015 115.598 1.00115.75 C

ATOM 11359 O ASN C 152 47.197 82.882 115.467 1.00119.93 O

ATOM 11360 N ALA C 153 49.086 81.916 114.773 1.00113.90 N

ATOM 11362 CA ALA C 153 49.016 82.419 113.383 1.00112.97 C

ATOM 11364 CB ALA C 153 50.362 83.049 112.914 1.00115.78 C

ATOM 11368 C ALA C 153 48.582 81.215 112.489 1.00105.40 C

ATOM 11369 O ALA C 153 49.190 80.118 112.536 1.00100.44 O

ATOM 11370 N LEU C 154 47.490 81.404 111.738 1.00104.22 N

ATOM 11372 CA LEU C 154 47.062 80.433 110.725 1.00 98.09 C

ATOM 11374 CB LEU C 154 45.803 80.913 109.980 1.00 99.06 C

ATOM 11377 CG LEU C 154 44.449 80.931 110.712 1.00100.59 C

ATOM 11379 CDl LEU C 154 44.035 82.369 111.263 1.00107.76 C

ATOM 11383 CD2 LEU C 154 43.376 80.317 109.788 1.00 96.43 C

ATOM 11387 C LEU C 154 48.178 80.250 109.706 1.00 96.18 C

ATOM 11388 O LEU C 154 48.764 81.229 109.238 1.00 99.72 O

ATOM 11389 N GLN C 155 48.466 78.997 109.357 1.00 90.49 N

ATOM 11391 CA GLN C 155 49.477 78.703 108.346 1.00 88.65 C

ATOM 11393 CB GLN C 155 50.264 77.418 108.660 1.00 84.72 C

ATOM 11396 CG GLN C 155 51.045 77.407 109.970 1.00 85.90 C

ATOM 11399 CD GLN C 155 51.946 78.589 110.099 1.00 91.43 C

ATOM 11400 OEl GLN C 155 52.738 78.847 109.204 1.00 93.14 O

ATOM 11401 NE2 GLN C 155 51.820 79.336 111.198 1.00 95.40 N

ATOM 11404 C GLN C 155 48.752 78.564 107.025 1.00 86.54 C

ATOM 11405 O GLN C 155 47.599 78.120 106.959 1.00 84.02 O

ATOM 11406 N SER C 156 49.404 78.988 105.966 1.00 87.95 N

ATOM 11408 CA SER C 156 48.872 78.684 104.665 1.00 86.39 C

ATOM 11410 CB SER C 156 47.818 79.707 104.245 1.00 89.74 C

ATOM 11413 OG SER C 156 48.427 80.797 103.581 1.00 95.70 O

ATOM 11415 C SER C 156 50.039 78.564 103.698 1.00 86.84 C

ATOM 11416 O SER C 156 51.075 79.207 103.873 1.00 88.72 O

ATOM 11417 N GLY C 157 49.867 77.656 102.735 1.00 84.26 N

ATOM 11419 CA GLY C 157 50.836 77.421 101.684 1.00 85.21 C

ATOM 11422 C GLY C 157 52.001 76.541 102.070 1.00 82.75 C

ATOM 11423 O GLY C 157 52.857 76.304 101.247 1.00 83.43 O

ATOM 11424 N ASN C 158 52.019 76.050 103.302 1.00 80.64 N ATOM 11426 CA ASN C 158 53.087 75.180 103.820 1.00 79.04 C

ATOM 11428 CB ASN C 158 53.786 75.891 104.976 1.00 81.79 C

ATOM 11431 CG ASN C 158 52.797 76.357 106.077 1.00 84.07 C

ATOM 11432 ODl ASN C 158 51.593 76.497 105.840 1.00 85.42 O

ATOM 11433 ND2 ASN C 158 53.315 76.578 107.292 1.00 87.62 N

ATOM 11436 C ASN C 158 52.554 73.770 104.259 1.00 74.13 C

ATOM 11437 O ASN C 158 53.185 73.076 105.074 1.00 72.30 O

ATOM 11438 N SER C 159 51.392 73.365 103.719 1.00 71.66 N

ATOM 11440 CA SER C 159 50.788 72.052 104.073 1.00 67.90 C

ATOM 11442 CB SER C 159 49.729 72.128 105.214 1.00 66.13 C

ATOM 11445 OG SER C 159 48.749 73.114 105.020 1.00 64.64 O

ATOM 11447 C SER C 159 50.183 71.335 102.905 1.00 66.31 C

ATOM 11448 O SER C 159 49.609 71.959 102.030 1.00 68.14 O

ATOM 11449 N GLN C 160 50.291 70.012 102.916 1.00 64.19 N

ATOM 11451 CA GLN C 160 49.644 69.174 101.896 1.00 62.64 C

ATOM 11453 CB GLN C 160 50.677 68.532 100.993 1.00 63.54 C

ATOM 11456 CG GLN C 160 51.374 69.456 100.096 1.00 65.64 C

ATOM 11459 CD GLN C 160 52.390 68.731 99.259 1.00 68.21 C

ATOM 11460 OEl GLN C 160 52.193 68.544 98.030 1.00 70.43 O

ATOM 11461 NE2 GLN C 160 53.480 68.295 99.904 1.00 66.25 N

ATOM 11464 C GLN C 160 48.905 68.054 102.548 1.00 59.52 C

ATOM 11465 O GLN C 160 49.353 67.499 103.546 1.00 58.40 O

ATOM 11466 N GLU C 161 47.794 67.673 101.945 1.00 58.74 N

ATOM 11468 CA GLU C 161 47.020 66.559 102.487 1.00 56.88 C

ATOM 11470 CB GLU C 161 45.748 67.079 103.199 1.00 57.07 C

ATOM 11473 CG GLU C 161 44.936 68.196 102.543 1.00 59.02 C

ATOM 11476 CD GLU C 161 43.833 68.709 103.487 1.00 61.54 C

ATOM 11477 OEl GLU C 161 44.130 69.229 104.606 1.00 63.55 O

ATOM 11478 OE2 GLU C 161 42.647 68.567 103.133 1.00 61.99 O

ATOM 11479 C GLU C 161 46.653 65.492 101.497 1.00 55.11 C

ATOM 11480 O GLU C 161 46.532 65.801 100.352 1.00 55.99 O

ATOM 11481 N SER C 162 46.556 64.230 101.937 1.00 53.99 N

ATOM 11483 CA SER C 162 45.689 63.253 101.252 1.00 54.45 C

ATOM 11485 CB SER C 162 46.338 61.980 100.687 1.00 54.88 C

ATOM 11488 OG SER C 162 47.640 61.877 100.980 1.00 54.80 O

ATOM 11490 C SER C 162 44.599 62.743 102.111 1.00 53.51 C

ATOM 11491 O SER C 162 44.721 62.768 103.346 1.00 53.28 O

ATOM 11492 N VAL C 163 43.602 62.185 101.394 1.00 53.67 N

ATOM 11494 CA VAL C 163 42.504 61.396 101.915 1.00 52.73 C

ATOM 11496 CB VAL C 163 41.162 61.948 101.478 1.00 52.14 C

ATOM 11498 CGl VAL C 163 40.071 61.623 102.477 1.00 52.07 C

ATOM 11502 CG2 VAL C 163 41.242 63.407 101.328 1.00 53.45 C

ATOM 11506 C VAL C 163 42.564 60.049 101.289 1.00 54.59 C

ATOM 11507 O VAL C 163 43.085 59.875 100.212 1.00 56.88 O

ATOM 11508 N THR C 164 41.975 59.088 101.948 1.00 55.77 N

ATOM 11510 CA THR C 164 41.851 57.795 101.389 1.00 58.56 C

ATOM 11512 CB THR C 164 41.900 56.737 102.484 1.00 59.66 C

ATOM 11514 OGl THR C 164 42.914 57.079 103.426 1.00 59.99 O

ATOM 11516 CG2 THR C 164 42.467 55.366 101.889 1.00 64.68 C

ATOM 11520 C THR C 164 40.566 57.687 100.624 1.00 59.35 C

ATOM 11521 O THR C 164 39.597 58.310 100.908 1.00 58.00 O

ATOM 11522 N GLU C 165 40.579 56.823 99.639 1.00 62.70 N

ATOM 11524 CA GLU C 165 39.368 56.246 99.108 1.00 63.98 C

ATOM 11526 CB GLU C 165 39.764 55.246 98.035 1.00 68.42 C

ATOM 11529 CG GLU C 165 40.394 55.913 96.779 1.00 74.03 C

ATOM 11532 CD GLU C 165 39.509 57.028 96.100 1.00 78.67 C

ATOM 11533 OEl GLU C 165 38.238 56.972 96.180 1.00 81.40 O

ATOM 11534 OE2 GLU C 165 40.078 57.978 95.467 1.00 80.96 O

ATOM 11535 C GLU C 165 38.537 55.561 100.192 1.00 62.40 C

ATOM 11536 O GLU C 165 39.094 55.035 101.158 1.00 62.62 O

ATOM 11537 N GLN C 166 37.206 55.570 100.001 1.00 61.60 N

ATOM 11539 CA GLN C 166 36.190 55.023 100.958 1.00 60.28 C

ATOM 11541 CB GLN C 166 34.789 55.255 100.390 1.00 60.22 C

ATOM 11544 CG GLN C 166 33.671 54.930 101.352 1.00 60.01 C

ATOM 11547 CD GLN C 166 32.343 55.571 101.001 1.00 57.99 C

ATOM 11548 OEl GLN C 166 31.947 55.629 99.846 1.00 60.56 O

ATOM 11549 NE2 GLN C 166 31.631 55.984 102.008 1.00 56.87 N

ATOM 11552 C GLN C 166 36.369 53.544 101.355 1.00 61.82 C ATOM 11553 O GLN C 166 36.668 52.732 100.536 1.00 63.96 O

ATOM 11554 N ASP C 167 36.172 53.205 102.611 1.00 61.44 N

ATOM 11556 CA ASP C 167 36.546 51.900 103.107 1.00 65.73 C

ATOM 11558 CB ASP C 167 36.746 51.988 104.586 1.00 65.19 C

ATOM 11561 CG ASP C 167 37.345 50.724 105.181 1.00 72.04 C

ATOM 11562 ODl ASP C 167 36.669 49.640 105.326 1.00 75.74 O

ATOM 11563 OD2 ASP C 167 38.529 50.768 105.587 1.00 76.75 O

ATOM 11564 C ASP C 167 35.428 50.923 102.904 1.00 69.41 C

ATOM 11565 O ASP C 167 34.325 51.175 103.348 1.00 68.59 O

ATOM 11566 N SER C 168 35.692 49.784 102.272 1.00 74.58 N

ATOM 11568 CA SER C 168 34.612 48.829 101.949 1.00 78.10 C

ATOM 11570 CB SER C 168 35.157 47.618 101.188 1.00 83.31 C

ATOM 11573 OG SER C 168 36.431 47.235 101.689 1.00 84.86 O

ATOM 11575 C SER C 168 33.831 48.435 103.227 1.00 78.77 C

ATOM 11576 O SER C 168 32.616 48.748 103.318 1.00 78.19 O

ATOM 11577 N LYS C 169 34.533 47.857 104.227 1.00 80.20 N

ATOM 11579 CA LYS C 169 33.923 47.466 105.543 1.00 81.36 C

ATOM 11581 CB LYS C 169 34.976 46.844 106.508 1.00 84.06 C

ATOM 11584 CG LYS C 169 35.667 45.526 106.043 1.00 90.82 C

ATOM 11587 CD LYS C 169 37.176 45.430 106.502 1.00 92.25 C

ATOM 11590 CE LYS C 169 37.919 44.219 105.925 1.00 98.14 C

ATOM 11593 NZ LYS C 169 37.925 43.042 106.880 1.00104.47 N

ATOM 11597 C LYS C 169 33.080 48.578 106.300 1.00 76.62 C

ATOM 11598 O LYS C 169 31.880 48.420 106.429 1.00 77.24 O

ATOM 11599 N ASP C 170 33.703 49.652 106.806 1.00 72.36 N

ATOM 11601 CA ASP C 170 32.992 50.745 107.525 1.00 68.94 C

ATOM 11603 CB ASP C 170 33.753 51.190 108.779 1.00 68.28 C

ATOM 11606 CG ASP C 170 35.172 51.717 108.499 1.00 68.33 C

ATOM 11607 ODl ASP C 170 35.669 51.859 107.357 1.00 68.00 O

ATOM 11608 OD2 ASP C 170 35.903 52.067 109.425 1.00 71.49 O

ATOM 11609 C ASP C 170 32.608 51.977 106.662 1.00 65.16 C

ATOM 11610 O ASP C 170 32.043 52.960 107.137 1.00 61.37 O

ATOM 11611 N SER C 171 32.914 51.881 105.374 1.00 65.83 N

ATOM 11613 CA SER C 171 32.547 52.884 104.369 1.00 63.62 C

ATOM 11615 CB SER C 171 31.104 52.585 103.921 1.00 64.50 C

ATOM 11618 OG SER C 171 30.278 53.545 104.481 1.00 62.30 O

ATOM 11620 C SER C 171 32.857 54.392 104.719 1.00 59.93 C

ATOM 11621 O SER C 171 32.140 55.332 104.368 1.00 58.66 O

ATOM 11622 N THR C 172 34.017 54.602 105.330 1.00 59.37 N

ATOM 11624 CA THR C 172 34.528 55.938 105.707 1.00 55.85 C

ATOM 11626 CB THR C 172 34.674 55.962 107.198 1.00 55.89 C

ATOM 11628 OGl THR C 172 35.487 57.071 107.513 1.00 59.13 O

ATOM 11630 CG2 THR C 172 35.511 54.826 107.712 1.00 57.10 C

ATOM 11634 C THR C 172 35.897 56.403 105.084 1.00 53.92 C

ATOM 11635 O THR C 172 36.617 55.676 104.436 1.00 54.08 O

ATOM 11636 N TYR C 173 36.228 57.655 105.324 1.00 52.30 N

ATOM 11638 CA TYR C 173 37.479 58.291 104.859 1.00 51.46 C

ATOM 11640 CB TYR C 173 37.166 59.643 104.193 1.00 49.71 C

ATOM 11643 CG TYR C 173 36.218 59.481 103.061 1.00 49.79 C

ATOM 11644 CDl TYR C 173 34.872 59.517 103.254 1.00 49.00 C

ATOM 11646 CEl TYR C 173 34.033 59.333 102.222 1.00 52.19 C

ATOM 11648 CZ TYR C 173 34.545 59.096 100.980 1.00 53.46 C

ATOM 11649 OH TYR C 173 33.727 58.910 99.884 1.00 58.02 O

ATOM 11651 CE2 TYR C 173 35.868 59.059 100.794 1.00 52.66 C

ATOM 11653 CD2 TYR C 173 36.680 59.236 101.810 1.00 51.00 C

ATOM 11655 C TYR C 173 38.513 58.493 105.961 1.00 51.35 C

ATOM 11656 O TYR C 173 38.240 58.326 107.138 1.00 51.36 O

ATOM 11657 N SER C 174 39.701 58.907 105.547 1.00 51.83 N

ATOM 11659 CA SER C 174 40.799 59.144 106.484 1.00 52.31 C

ATOM 11661 CB SER C 174 41.538 57.809 106.747 1.00 54.03 C

ATOM 11664 OG SER C 174 41.293 57.287 108.023 1.00 52.58 O

ATOM 11666 C SER C 174 41.742 60.193 105.881 1.00 51.52 C

ATOM 11667 O SER C 174 42.203 60.034 104.801 1.00 52.07 O

ATOM 11668 N LEU C 175 42.048 61.249 106.587 1.00 51.86 N

ATOM 11670 CA LEO C 175 42.874 62.315 106.019 1.00 52.36 C

ATOM 11672 CB LEU C 175 42.244 63.649 106.309 1.00 51.94 C

ATOM 11675 CG LEO C 175 42.542 64.815 105.400 1.00 51.62 C

ATOM 11677 CDl LEU C 175 41.344 65.221 104.572 1.00 50.59 C ATOM 11681 CD2 LED C 175 42.946 65.915 106.230 1.00 52.90 C

ATOM 11685 C LEU C 175 44.220 62.353 106.658 1.00 54.29 C

ATOM 11686 O LEU C 175 44.426 61.809 107.718 1.00 55.77 O

ATOM 11687 N SER C 176 45.160 63.032 106.029 1.00 55.63 N

ATOM 11689 CA SER C 176 46.416 63.293 106.700 1.00 56.66 C

ATOM 11691 CB SER C 176 47.413 62.207 106.400 1.00 57.54 C

ATOM 11694 OG SER C 176 48.503 62.771 105.728 1.00 61.11 O

ATOM 11696 C SER C 176 46.915 64.623 106.226 1.00 57.20 C

ATOM 11697 O SER C 176 46.943 64.902 105.017 1.00 56.36 O

ATOM 11698 N SER C 177 47.292 65.468 107.193 1.00 58.72 N

ATOM 11700 CA SER C 177 47.898 66.776 106.878 1.00 59.21 C

ATOM 11702 CB SER C 177 47.171 67.915 107.543 1.00 59.79 C

ATOM 11705 OG SER C 177 47.283 69.028 106.687 1.00 61.45 O

ATOM 11707 C SER C 177 49.295 66.763 107.325 1.00 59.52 C

ATOM 11708 O SER C 177 49.564 66.372 108.408 1.00 59.47 O

ATOM 11709 N THR C 178 50.183 67.147 106.438 1.00 60.76 N

ATOM 11711 CA THR C 178 51.600 67.208 106.743 1.00 62.63 C

ATOM 11713 CB THR C 178 52.400 66.234 105.865 1.00 62.33 C

ATOM 11715 OGl THR C 178 52.028 64.884 106.194 1.00 62.25 O

ATOM 11717 CG2 THR C 178 53.836 66.288 106.225 1.00 63.69 C

ATOM 11721 C THR C 178 52.063 68.655 106.630 1.00 64.52 C

ATOM 11722 O THR C 178 52.212 69.231 105.532 1.00 65.27 O

ATOM 11723 N LEU C 179 52.186 69.261 107.800 1.00 66.36 N

ATOM 11725 CA LEU C 179 52.856 70.552 107.944 1.00 69.87 C

ATOM 11727 CB LEU C 179 52.540 71.183 109.294 1.00 71.47 C

ATOM 11730 CG LEU C 179 53.257 72.492 109.522 1.00 75.84 C

ATOM 11732 CDl LEU C 179 52.876 73.551 108.468 1.00 78.63 C

ATOM 11736 CD2 LEU C 179 52.886 72.972 110.888 1.00 79.77 C

ATOM 11740 C LEU C 179 54.370 70.431 107.757 1.00 71.38 C

ATOM 11741 O LEU C 179 55.035 69.600 108.367 1.00 71.08 O

ATOM 11742 N THR C 180 54.892 71.257 106.871 1.00 73.42 N

ATOM 11744 CA THR C 180 56.279 71.148 106.515 1.00 75.49 C

ATOM 11746 CB THR C 180 56.400 70.535 105.098 1.00 74.91 C

ATOM 11748 OGl THR C 180 55.394 69.499 104.878 1.00 70.42 O

ATOM 11750 CG2 THR C 180 57.757 69.818 104.953 1.00 76.14 C

ATOM 11754 C THR C 180 57.016 72.488 106.671 1.00 79.35 C

ATOM 11755 O THR C 180 56.499 73.558 106.316 1.00 80.35 O

ATOM 11756 N LEU C 181 58.218 72.376 107.238 1.00 81.53 N

ATOM 11758 CA LEU C 181 59.046 73.493 107.698 1.00 86.10 C

ATOM 11760 CB LEU C 181 58.626 73.845 109.107 1.00 87.52 C

ATOM 11763 CG LEU C 181 57.270 74.495 109.258 1.00 88.57 C

ATOM 11765 CDl LEU C 181 57.123 74.780 110.767 1.00 91.29 C

ATOM 11769 CD2 LEU C 181 57.124 75.802 108.372 1.00 92.28 C

ATOM 11773 C LEU C 181 60.531 73.127 107.790 1.00 87.89 C

ATOM 11774 O LEU C 181 60.834 72.002 108.185 1.00 87.01 O

ATOM 11775 N SER C 182 61.451 74.058 107.498 1.00 90.99 N

ATOM 11777 CA SER C 182 62.872 73.750 107.637 1.00 92.84 C

ATOM 11779 CB SER C 182 63.746 74.837 107.014 1.00 96.46 C

ATOM 11782 OG SER C 182 64.103 75.790 107.977 1.00 99.90 O

ATOM 11784 C SER C 182 63.126 73.614 109.129 1.00 94.76 C

ATOM 11785 O SER C 182 62.526 74.368 109.888 1.00 96.46 O

ATOM 11786 N LYS C 183 63.973 72.665 109.562 1.00 95.19 N

ATOM 11788 CA LYS C 183 64.345 72.530 111.001 1.00 97.89 C

ATOM 11790 CB LYS C 183 65.603 71.666 111.218 1.00 99.64 C

ATOM 11797 C LYS C 183 64.651 73.848 111.670 1.00102.52 C

ATOM 11798 O LYS C 183 64.684 73.922 112.904 1.00105.22 O

ATOM 11799 N ALA C 184 64.965 74.851 110.850 1.00104.32 N

ATOM 11801 CA ALA C 184 65.255 76.202 111.322 1.00109.49 C

ATOM 11803 CB ALA C 184 65.910 76.997 110.192 1.00111.80 C

ATOM 11807 C ALA C 184 64.015 76.946 111.857 1.00109.86 C

ATOM 11808 O ALA C 184 64.043 77.545 112.937 1.00113.60 O

ATOM 11809 N ASP C 185 62.940 76.921 111.075 1.00106.51 N

ATOM 11811 CA ASP C 185 61.677 77.545 111.468 1.00106.54 C

ATOM 11813 CB ASP C 185 60.662 77.485 110.312 1.00103.12 C

ATOM 11816 CG ASP C 185 61.105 78.269 109.052 1.00106.46 C

ATOM 11817 ODl ASP C 185 61.944 79.204 109.095 1.00110.53 O

ATOM 11818 OD2 ASP C 185 60.608 78.007 107.935 1.00108.38 O

ATOM 11819 C ASP C 185 61.087 76.833 112.689 1.00104.72 C ATOM 11820 O ASP C 185 60.448 77.451 113.547 1.00107.05 O

ATOM 11821 N TYR C 186 61.307 75.525 112.758 1.00100.91 N

ATOM 11823 CA TYR C 186 60.650 74.704 113.761 1.00 99.44 C

ATOM 11825 CB TYR C 186 60.821 73.215 113.428 1.00 95.52 C

ATOM 11828 CG TYR C 186 60.182 72.269 114.423 1.00 94.50 C

ATOM 11829 CDl TYR C 186 58.820 72.302 114.676 1.00 92.95 C

ATOM 11831 CEl TYR C 186 58.228 71.416 115.611 1.00 92.00 C

ATOM 11833 CZ TYR C 186 59.018 70.511 116.287 1.00 92.21 C

ATOM 11834 OH TYR C 186 58.475 69.656 117.188 1.00 90.68 O

ATOM 11836 CE2 TYR C 186 60.364 70.460 116.052 1.00 95.55 C

ATOM 11838 CD2 TYR C 186 60.948 71.339 115.126 1.00 96.74 C

ATOM 11840 C TYR C 186 61.198 75.043 115.143 1.00104.67 C

ATOM 11841 O TYR C 186 60.414 75.165 116.098 1.00106.10 O

ATOM 11842 N GLO C 187 62.532 75.225 115.226 1.00107.76 N

ATOM 11844 CA GLO C 187 63.227 75.577 116.466 1.00112.95 C

ATOM 11846 CB GLO C 187 64.703 75.893 116.196 1.00115.75 C

ATOM 11853 C GLO C 187 62.516 76.763 117.096 1.00116.87 C

ATOM 11854 O GLO C 187 62.133 76.705 118.270 1.00119.20 O

ATOM 11855 N LYS C 188 62.254 77.785 116.272 1.00117.68 N

ATOM 11857 CA LYS C 188 61.806 79.119 116.728 1.00123.34 C

ATOM 11859 CB LYS C 188 62.258 80.186 115.693 1.00125.15 C

ATOM 11866 C LYS C 188 60.293 79.334 117.137 1.00122.83 C

ATOM 11867 O LYS C 188 59.870 80.480 117.337 1.00127.37 O

ATOM 11868 N HIS C 189 59.498 78.271 117.295 1.00118.14 N

ATOM 11870 CA HIS C 189 58.118 78.401 117.838 1.00118.23 C

ATOM 11872 CB HIS C 189 57.039 78.402 116.701 1.00113.37 C

ATOM 11875 CG HIS C 189 57.197 79.528 115.718 1.00115.83 C

ATOM 11876 NDl HIS C 189 56.933 80.841 116.040 1.00122.53 N

ATOM 11878 CEl HIS C 189 57.218 81.617 115.011 1.00123.27 C

ATOM 11880 NE2 HIS C 189 57.650 80.854 114.025 1.00118.61 N

ATOM 11882 CD2 HIS C 189 57.647 79.542 114.440 1.00114.31 C

ATOM 11884 C HIS C 189 57.835 77.295 118.865 1.00116.94 C

ATOM 11885 O HIS C 189 58.396 76.204 118.757 1.00114.30 O

ATOM 11886 N LYS C 190 56.965 77.557 119.843 1.00119.39 N

ATOM 11888 CA LYS C 190 56.663 76.554 120.870 1.00119.33 C

ATOM 11890 CB LYS C 190 56.311 77.194 122.220 1.00126.70 C

ATOM 11897 C LYS C 190 55.537 75.659 120.451 1.00113.38 C

ATOM 11898 O LYS C 190 55.777 74.497 120.119 1.00109.64 O

ATOM 11899 N VAL C 191 54.318 76.222 120.457 1.00113.48 N

ATOM 11901 CA VAL C 191 53.055 75.504 120.222 1.00108.33 C

ATOM 11903 CB VAL C 191 51.789 76.364 120.601 1.00110.82 C

ATOM 11905 CGl VAL C 191 50.492 75.634 120.279 1.00106.29 C

ATOM 11909 CG2 VAL C 191 51.761 76.701 122.048 1.00117.81 C

ATOM 11913 C VAL C 191 52.932 75.172 118.762 1.00102.06 C

ATOM 11914 O VAL C 191 53.386 75.958 117.927 1.00101.58 O

ATOM 11915 N TYR C 192 52.284 74.024 118.493 1.00 97.43 N

ATOM 11917 CA TYR C 192 51.969 73.511 117.156 1.00 91.95 C

ATOM 11919 CB TYR C 192 53.046 72.561 116.731 1.00 89.41 C

ATOM 11922 CG TYR C 192 54.216 73.257 116.212 1.00 90.56 C

ATOM 11923 CDl TYR C 192 55.338 73.417 116.990 1.00 97.01 C

ATOM 11925 CEl TYR C 192 56.440 74.109 116.506 1.00 99.63 C

ATOM 11927 CZ TYR C 192 56.404 74.640 115.220 1.00 96.17 C

ATOM 11928 OH TYR C 192 57.487 75.340 114.715 1.00 99.78 O

ATOM 11930 CE2 TYR C 192 55.283 74.479 114.450 1.00 90.48 C

ATOM 11932 CD2 TYR C 192 54.194 73.817 114.961 1.00 87.27 C

ATOM 11934 C TYR C 192 50.653 72.713 117.135 1.00 89.66 C

ATOM 11935 O TYR C 192 50.545 71.644 117.772 1.00 89.20 O

ATOM 11936 N ALA C 193 49.684 73.192 116.352 1.00 88.28 N

ATOM 11938 CA ALA C 193 48.281 72.900 116.635 1.00 87.68 C

ATOM 11940 CB ALA C 193 47.569 74.139 117.180 1.00 91.96 C

ATOM 11944 C ALA C 193 47.588 72.431 115.403 1.00 83.46 C

ATOM 11945 O ALA C 193 47.920 72.887 114.312 1.00 83.57 O

ATOM 11946 N CYS C 194 46.602 71.551 115.588 1.00 81.07 N

ATOM 11948 CA CYS C 194 45.912 70.929 114.502 1.00 76.76 C

ATOM 11950 CB CYS C 194 46.244 69.455 114.509 1.00 74.32 C

ATOM 11953 SG CYS C 194 45.544 68.692 113.051 1.00 76.90 S

ATOM 11954 C CYS C 194 44.444 71.168 114.783 1.00 76.26 C

ATOM 11955 O CYS C 194 43.916 70.603 115.720 1.00 77.18 O ATOM 11956 N GLU C 195 43.790 72.021 113.991 00 75.58 N

ATOM 11958 CA GLϋ C 195 42.376 72.394 114.203 00 75.90 C

ATOM 11960 CB GLU C 195 42.230 73.907 114.332 1.00 80.39 C

ATOM 11963 CG GLU C 195 40.824 74.381 114.736 .00 83.63 C

ATOM 11966 CD GLU C 195 40.380 75.689 114.059 .00 87.24 C

ATOM 11967 OEl GLU C 195 41.166 76.308 113.301 .00 87.78 O

ATOM 11968 OE2 GLU C 195 39.230 76.118 114.284 .00 89.97 O

ATOM 11969 C GLU C 195 41.369 71.845 113.145 .00 71.74 C

ATOM 11970 O GLU C 195 41.127 72.413 112.070 .00 70.64 O

ATOM 11971 N VAL C 196 40.744 70.741 113.531 .00 69.55 N

ATOM 11973 CA VAL C 196 39.805 70.023 112.708 .00 65.72 C

ATOM 11975 CB VAL C 196 39.792 68.572 113.122 .00 63.49 C

ATOM 11977 CGl VAL C 196 38.864 67.812 112.277 1.00 60.95 C

ATOM 11981 CG2 VAL C 196 41.195 67.993 113.025 1.00 62.64 C

ATOM 11985 C VAL C 196 38.388 70.591 112.830 .00 66.93 C

ATOM 11986 O VAL C 196 37.907 70.990 113.890 .00 68.84 O

ATOM 11987 N THR C 197 37.727 70.587 111.693 .00 65.22 N

ATOM 11989 CA THR C 197 36.375 71.068 111.555 .00 66.67 C

ATOM 11991 CB THR C 197 36.395 72.420 110.849 .00 68.91 C

ATOM 11993 OGl THR C 197 37.268 73.302 111.567 00 73.48 O

ATOM 11995 CG2 THR C 197 35.026 73.088 110.862 1.00 70.65 C

ATOM 11999 C THR C 197 35.623 70.042 110.718 1.00 64.04 C

ATOM 12000 O THR C 197 36.033 69.666 109.600 1.00 62.98 O

ATOM 12001 N HIS C 198 34.511 69.574 111.243 1.00 64.16 N

ATOM 12003 CA HIS C 198 33.842 68.464 110.617 1.00 61.33 C

ATOM 12005 CB HIS C 198 34.562 67.151 110.973 1.00 59.74 C

ATOM 12008 CG HIS C 198 33.971 65.964 110.287 .00 58.02 C

ATOM 12009 NDl HIS C 198 34.128 65.750 108.936 .00 57.39 N

ATOM 12011 CEl HIS C 198 33.441 64.677 108.594 .00 56.71 C

ATOM 12013 NE2 HIS C 198 32.826 64.208 109.663 .00 54.74 N

ATOM 12015 CD2 HIS C 198 33.140 64.993 110.736 1.00 55.73 C

ATOM 12017 C HIS C 198 32.439 68.464 111.115 1.00 62.12 C

ATOM 12018 O HIS C 198 32.191 68.978 112.181 1.00 65.48 O

ATOM 12019 N GLN C 199 31.529 67.905 110.337 1.00 60.45 N

ATOM 12021 CA GLN C 199 30.113 67.879 110.673 00 61.89 C

ATOM 12023 CB GLN C 199 29.321 67.205 109.531 00 60.84 C

ATOM 12026 CG GLN C 199 27.791 67.469 109.465 .00 62.62 C

ATOM 12029 CD GLN C 199 27.118 66.758 108.272 .00 62.17 C

ATOM 12030 OEl GLN C 199 27.603 66.780 107.132 .00 62.44 O

ATOM 12031 NE2 GLN C 199 26.021 66.130 108.541 .00 62.82 N

ATOM 12034 C GLN C 199 29.881 67.134 111.977 1.00 62.72 C

ATOM 12035 O GLN C 199 28.947 67.431 112.702 1.00 64.57 O

ATOM 12036 N GLY C 200 30.759 66.186 112.294 1.00 61.62 N

ATOM 12038 CA GLY C 200 30.553 65.315 113.435 1 .00 62.79 C

ATOM 12041 C GLY C 200 31.172 65.785 114.730 1.00 65.81 C

ATOM 12042 O GLY C 200 31.463 64.929 115.553 1.00 68.31 O

ATOM 12043 N LEU C 201 31.378 67.103 114.910 1.00 67.08 N

ATOM 12045 CA LEU C 201 32.111 67.693 116.042 1.00 69.26 C

ATOM 12047 CB LEU C 201 33.565 67.903 115.686 1.00 67.39 C

ATOM 12050 CG LEU C 201 34.388 66.703 115.257 .00 64.11 C

ATOM 12052 CDl LEU C 201 35.552 67.128 114.421 .00 62.77 C

ATOM 12056 CD2 LEU C 201 34.886 65.911 116.436 .00 66.42 C

ATOM 12060 C LEU C 201 31.490 69.063 116.339 .00 73.17 C

ATOM 12061 O LEU C 201 31.436 69.928 115.455 .00 72.65 O

ATOM 12062 N SER C 202 31.017 69.270 117.568 .00 77.26 N

ATOM 12064 CA SER C 202 30.015 70.328 117.787 .00 81.12 C

ATOM 12066 CB SER C 202 29.362 70.258 119.187 .00 85.90 C

ATOM 12069 OG SER C 202 29.672 69.042 119.838 .00 85.41 O

ATOM 12071 C SER C 202 30.667 71.668 117.561 .00 82.89 C

ATOM 12072 O SER C 202 30.102 72.570 116.969 .00 83.10 O

ATOM 12073 N SER C 203 31.868 71.774 118.085 .00 84.21 N

ATOM 12075 CA SER C 203 32.746 72.851 117.732 .00 86.10 C

ATOM 12077 CB SER C 203 32.963 73.783 118.912 .00 92.36 C

ATOM 12080 OG SER C 203 33.402 73.025 120.003 .00 93.55 O

ATOM 12082 C SER C 203 34.044 72.186 117.323 .00 83.05 C

ATOM 12083 O SER C 203 34.262 70.983 117.626 .00 81.22 O

ATOM 12084 N PRO C 204 34.873 72.948 116.593 00 82.81 N

ATOM 12085 CA PRO C 204 36.239 72.533 116.233 1.00 79.98 C ATOM 12087 CB PRO C 204 36.927 73.854 115.863 1.00 82.52 C

ATOM 12090 CG PRO C 204 35.815 74.803 115.476 1.00 85.07 C

ATOM 12093 CD PRO C 204 34.522 74.253 115.995 1.00 85.30 C

ATOM 12096 C PRO C 204 37.021 71.856 117.358 1.00 80.67 C

ATOM 12097 O PRO C 204 36.880 72.153 118.548 1.00 85.19 O

ATOM 12098 N VAL C 205 37.859 70.933 116.950 1.00 76.65 N

ATOM 12100 CA VAL C 205 38.675 70.224 117.872 1.00 77.69 C

ATOM 12102 CB VAL C 205 38.367 68.781 117.787 1.00 74.45 C

ATOM 12104 CGl VAL C 205 39.541 67.929 118.243 1.00 74.59 C

ATOM 12108 CG2 VAL C 205 37.123 68.551 118.602 1.00 76.84 C

ATOM 12112 C VAL C 205 40.101 70.505 117.535 1.00 77.92 C

ATOM 12113 O VAL C 205 40.492 70.477 116.391 1.00 75.11 O

ATOM 12114 N THR C 206 40.873 70.789 118.566 1.00 82.28 N

ATOM 12116 CA THR C 206 42.253 71.122 118.415 1.00 82.99 C

ATOM 12118 CB THR C 206 42.454 72.498 118.958 1.00 88.12 C

ATOM 12120 OGl THR C 206 41.528 73.357 118.281 1.00 89.49 O

ATOM 12122 CG2 THR C 206 43.880 73.065 118.602 1.00 88.94 C

ATOM 12126 C THR C 206 43.102 70.134 119.141 1.00 83.61 C

ATOM 12127 O THR C 206 42.741 69.648 120.193 1.00 86.65 O

ATOM 12128 N LYS C 207 44.257 69.863 118.563 1.00 82.04 N

ATOM 12130 CA LYS C 207 45.180 68.869 119.060 1.00 82.54 C

ATOM 12132 CB LYS C 207 45.015 67.583 118.263 1.00 78.30 C

ATOM 12135 CG LYS C 207 43.851 66.746 118.747 1.00 79.34 C

ATOM 12138 CD LYS C 207 44.253 65.776 119.859 1.00 83.48 C

ATOM 12141 CE LYS C 207 43.082 65.543 120.827 1.00 87.11 C

ATOM 12144 NZ LYS C 207 43.103 64.157 121.312 1.00 89.42 N

ATOM 12148 C LYS C 207 46.566 69.432 118.866 1.00 83.38 C

ATOM 12149 O LYS C 207 46.950 69.716 117.727 1.00 79.79 O

ATOM 12150 N SER C 208 47.307 69.585 119.974 1.00 88.00 N

ATOM 12152 CA SER C 208 48.616 70.245 119.940 1.00 89.86 C

ATOM 12154 CB SER C 208 48.480 71.696 120.405 1.00 94.01 C

ATOM 12157 OG SER C 208 48.739 71.839 121.786 1.00101.12 O

ATOM 12159 C SER C 208 49.701 69.477 120.706 1.00 92.09 C

ATOM 12160 O SER C 208 49.485 68.338 121.104 1.00 91.27 O

ATOM 12161 N PHE C 209 50.881 70.092 120.841 1.00 94.82 N

ATOM 12163 CA PHE C 209 52.047 69.472 121.487 1.00 97.65 C

ATOM 12165 CB PHE C 209 52.583 68.375 120.587 1.00 93.33 C

ATOM 12168 CG PHE C 209 53.213 68.915 119.352 1.00 90.96 C

ATOM 12169 CDl PHE C 209 54.542 69.293 119.354 1.00 92.49 C

ATOM 12171 CEl PHE C 209 55.156 69.817 118.232 1.00 90.22 C

ATOM 12173 CZ PHE C 209 54.445 69.986 117.093 1.00 86.31 C

ATOM 12175 CE2 PHE C 209 53.081 69.625 117.063 1.00 85.26 C

ATOM 12177 CD2 PHE C 209 52.471 69.103 118.197 1.00 87.32 C

ATOM 12179 C PHE C 209 53.203 70.469 121.743 1.00101.51 C

ATOM 12180 O PHE C 209 53.169 71.618 121.266 1.00101.04 O

ATOM 12181 N ASN C 210 54.241 69.987 122.454 1.00105.05 N

ATOM 12183 CA ASN C 210 55.489 70.740 122.698 1.00109.04 C

ATOM 12185 CB ASN C 210 56.296 70.878 121.379 1.00104.70 C

ATOM 12188 CG ASN C 210 57.652 71.550 121.525 .00107.23 C

ATOM 12189 ODl ASN C 210 58.002 72.407 120.710 .00103.98 O

ATOM 12190 ND2 ASN C 210 58.447 71.118 122.493 .00110.21 N

ATOM 12193 C ASN C 210 55.024 72.070 123.298 .00113.97 C

ATOM 12194 O ASN C 210 55.282 73.132 122.742 1.00115.08 O

ATOM 12195 N ARG C 211 54.328 71.954 124.444 1.00118.00 N

ATOM 12197 CA ARG C 211 53.444 72.976 125.069 1.00121.86 C

ATOM 12199 CB ARG C 211 54.110 74.377 125.154 1.00126.69 C

ATOM 12208 C ARG C 211 52.005 73.001 124.427 1.00117.02 C

ATOM 12209 O ARG C 211 51.034 73.584 124.925 1.00119.42 O

ATOM 12210 OXT ARG C 211 51.618 72.421 123.385 1.00109.85 O

ATOM 12211 N ALA D 1 41.982 30.461 82.277 1.00 57.00 N

ATOM 12213 CA ALA D 1 41.459 31.172 81.013 1.00 55.46 C

ATOM 12215 CB ALA D 1 39.904 31.400 81.090 1.00 56.48 C

ATOM 12219 C ALA D 1 42.126 32.481 80.527 1.00 50.69 C

ATOM 12220 O ALA D 1 43.285 32.669 80.747 1.00 52.53 O

ATOM 12223 N VAL D 2 41.421 33.378 79.851 1.00 47.38 N

ATOM 12225 CA VAL D 2 42.079 34.564 79.219 1.00 44.48 C

ATOM 12227 CB VAL D 2 41.096 35.532 78.483 1.00 41.76 C

ATOM 12229 CGl VAL D 2 41.905 36.738 77.915 1.00 40.38 C ATOM 12233 CG2 VAL D 2 40.388 34.848 77.355 1.00 39.69 C

ATOM 12237 C VAL D 2 42.842 35.498 80.122 1.00 44.26 C

ATOM 12238 O VAL D 2 42.298 36.058 81.022 1.00 44.63 O

ATOM 12239 N GLN D 3 44.102 35.758 79.839 1.00 45.24 N

ATOM 12241 CA GLN D 3 44.919 36.578 80.772 1.00 45.86 C

ATOM 12243 CB GLN D 3 45.720 35.704 81.745 1.00 48.64 C

ATOM 12246 CG GLN D 3 44.864 34.972 82.827 1.00 51.62 C

ATOM 12249 CD GLN D 3 45.710 34.463 84.014 1.00 59.14 C

ATOM 12250 OEl GLN D 3 46.947 34.642 84.062 1.00 62.63 O

ATOM 12251 NE2 GLN D 3 45.053 33.840 84.973 1.00 62.87 N

ATOM 12254 C GLN D 3 45.815 37.442 79.938 1.00 43.72 C

ATOM 12255 O GLN D 3 46.250 36.962 78.925 1.00 44.39 O

ATOM 12256 N LEU D 4 46.002 38.713 80.310 1.00 42.40 N

ATOM 12258 CA LEO D 4 46.977 39.641 79.686 1.00 40.47 C

ATOM 12260 CB LED D 4 46.256 40.846 79.083 1.00 37.49 C

ATOM 12263 CG LEU D 4 45.152 40.660 78.040 1.00 36.95 C

ATOM 12265 CDl LEU D 4 45.432 41.577 76.858 1.00 36.62 C

ATOM 12269 CD2 LEU D 4 45.043 39.356 77.504 1.00 39.31 C

ATOM 12273 C LEU D 4 47.969 40.192 80.723 1.00 41.49 C

ATOM 12274 O LEU D 4 47.599 40.842 81.665 1.00 41.51 O

ATOM 12275 N LYS D 5 49.250 39.970 80.549 1.00 43.23 N

ATOM 12277 CA LYS D 5 50.217 40.446 81.543 1.00 45.14 C

ATOM 12279 CB LYS D 50.892 39.284 82.282 1.00 48.88 C

ATOM 12282 CG LYS D 5 49.903 38.536 83.266 1.00 54.47 C

ATOM 12285 CD LYS D 5 50.560 37.297 83.990 1.00 60.79 C

ATOM 12288 CE LYS D 5 49.635 36.013 83.904 1.00 63.31 C

ATOM 12291 NZ LYS D 5 50.408 34.721 84.358 1.00 69.55 N

ATOM 12295 C LYS D 5 51.231 41.305 80.900 1.00 43.29 C

ATOM 12296 O LYS D 5 51.789 40.931 79.897 1.00 43.73 O

ATOM 12297 N GLN D 6 51.474 42.461 81.495 1.00 42.41 N

ATOM 12299 CA GLN D 6 52.383 43.434 80.924 1.00 41.52 C

ATOM 12301 CB GLN D 6 51.796 44.835 81.003 1.00 40.15 C

ATOM 12304 CG GLN D 6 50.406 44.997 80.357 1.00 39.53 C

ATOM 12307 CD GLN D 6 49.771 46.341 80.616 1.00 38.13 C

ATOM 12308 OEl GLN D 6 50.442 47.334 80.783 1.00 39.92 O

ATOM 12309 NE2 GLN D 6 48.468 46.370 80.597 1.00 40.10 N

ATOM 12312 C GLN D 6 53.668 43.410 81.676 1.00 43.59 C

ATOM 12313 O GLN D 6 53.675 43.182 82.887 1.00 43.49 O

ATOM 12314 N SER D 7 54.749 43.568 80.920 1.00 44.87 N

ATOM 12316 CA SER D 7 56.016 44.080 81.435 1.00 48.01 C

ATOM 12318 CB SER D 7 57.107 42.989 81.406 1.00 51.52 C

ATOM 12321 OG SER D 7 57.386 42.519 80.095 1.00 51.53 O

ATOM 12323 C SER D 7 56.521 45.303 80.675 1.00 47.70 C

ATOM 12324 O SER D 7 56.324 45.395 79.469 1.00 46.37 O

ATOM 12325 N GLY D 8 57.216 46.210 81.364 1.00 50.18 N

ATOM 12327 CA GLY D 8 57.911 47.315 80.713 1.00 50.86 C

ATOM 12330 C GLY D 8 58.393 48.422 81.619 1.00 52.58 C

ATOM 12331 O GLY D 8 57.780 48.763 82.605 1.00 51.07 O

ATOM 12332 N PRO D 9 59.516 49.021 81.266 1.00 56.53 N

ATOM 12333 CA PRO D 9 60.030 50.159 82.043 1.00 58.30 C

ATOM 12335 CB PRO D 9 61.288 50.586 81.284 1.00 61.09 C

ATOM 12338 CG PRO D 9 61.824 49.267 80.591 1.00 62.53 C

ATOM 12341 CD PRO D 9 60.435 48.657 80.162 1.00 58.96 C

ATOM 12344 C PRO D 9 59.005 51.228 82.035 1.00 56.45 C

ATOM 12345 O PRO D 9 58.635 51.619 80.919 1.00 55.51 O

ATOM 12346 N GLY D 10 58.485 51.541 83.237 1.00 56.24 N

ATOM 12348 CA GLY D 10 57.666 52.714 83.525 1.00 54.81 C

ATOM 12351 C GLY D 10 58.271 54.154 83.662 1.00 55.43 C

ATOM 12352 O GLY D 10 57.660 55.095 83.144 1.00 53.90 O

ATOM 12353 N LEU D 11 59.401 54.365 84.340 1.00 56.80 N

ATOM 12355 CA LEU D 11 60.044 55.699 84.289 1.00 57.96 C

ATOM 12357 CB LEU D 11 61.148 55.834 85.329 1.00 61.18 C

ATOM 12360 CG LEU D 11 61.792 57.218 85.406 1.00 62.40 C

ATOM 12362 CDl LEU D 11 60.836 58.390 85.187 1.00 61.71 C

ATOM 12366 CD2 LEU D 11 62.429 57.397 86.726 1.00 63.46 C

ATOM 12370 C LEU D 11 60.627 55.983 82.904 1.00 57.05 C

ATOM 12371 O LEU D 11 61.347 55.208 82.383 1.00 58.70 O

ATOM 12372 N VAL D 12 60.292 57.085 82.291 1.00 55.69 N ATOM 12374 CA VAL D 12 60.629 57.284 80.914 .00 55.00 C

ATOM 12376 CB VAL D 12 59.409 57.062 80.020 .00 52.03 C

ATOM 12378 CGl VAL D 12 59.667 57.583 78.591 .00 54.04 C

ATOM 12382 CG2 VAL D 12 59.123 55.658 79.921 .00 50.83 C

ATOM 12386 C VAL D 12 61.019 58.701 80.732 .00 56.49 C

ATOM 12387 O VAL D 12 60.264 59.589 81.020 .00 55.45 O

ATOM 12388 N GLN D 13 62.182 58.916 80.163 .00 59.59 N

ATOM 12390 CA GLN D 13 62.707 60.278 80.045 .00 62.52 C

ATOM 12392 CB GLN D 13 64.212 60.305 79.899 .00 65.71 C

ATOM 12395 CG GLN D 13 64.776 60.399 81.258 .00 69.08 C

ATOM 12398 CD GLN D 13 66.219 60.422 81.271 .00 77.09 C

ATOM 12399 OEl GLN D 13 66.874 60.460 80.225 .00 81.75 O

ATOM 12400 NE2 GLN D 13 66.770 60.414 82.464 .00 82.68 N

ATOM 12403 C GLN D 13 62.064 60.980 78.931 .00 61.31 C

ATOM 12404 O GLN D 13 61.775 60.374 77.918 .00 60.31 O

ATOM 12405 N PRO D 14 61.769 62.245 79.137 ,00 62.39 N

ATOM 12406 CA PRO D 14 61.018 62.986 78.155 .00 61.94 C

ATOM 12408 CB PRO D 14 60.741 64.296 78.849 .00 63.94 C

ATOM 12411 CG PRO D 14 61.829 64.410 79.730 .00 66.71 C

ATOM 12414 CD PRO D 14 62.070 63.082 80.291 .00 64.87 C

ATOM 12417 C PRO D 14 61.835 63.107 76.888 .00 63.56 C

ATOM 12418 O PRO D 14 63.036 63.175 76.841 .00 63.90 O

ATOM 12419 N SER D 15 61.050 62.965 75.841 .00 62.98 N

ATOM 12421 CA SER D 15 61.451 62.904 74.452 .00 64.41 C

ATOM 12423 CB SER D 15 62.324 64.072 74.064 .00 67.55 C

ATOM 12426 OG SER D 15 63.444 63.478 73.590 .00 66.46 O

ATOM 12428 C SER D 15 62.057 61.533 74.072 .00 64.44 C

ATOM 12429 O SER D 15 62.277 61.275 72.902 .00 65.45 O

ATOM 12430 N GLN D 16 62.212 60.620 75.032 .00 64.20 N

ATOM 12432 CA GLN D 16 62.561 59.213 IA. Ill .00 63.39 C

ATOM 12434 CB GLN D 16 63.626 58.733 75.704 .00 65.81 C

ATOM 12437 CG GLN D 16 64.952 58.300 75.040 ,00 71.75 C

ATOM 12440 CD GLN D 16 65.920 58.044 76.159 ,00 80.91 C

ATOM 12441 OEl GLN D 16 65.494 58.154 77.339 ,00 85.18 O

ATOM 12442 NE2 GLN D 16 67.191 57.708 75.856 1.00 83.89 N

ATOM 12445 C GLN D 16 61.346 58.241 74.614 1.00 57.84 C

ATOM 12446 O GLN D 16 60.221 58.667 74.789 1.00 56.16 O

ATOM 12447 N SER D 17 61.557 56.958 74.323 1.00 56.20 N

ATOM 12449 CA SER D 17 60.435 56.035 74.025 1.00 53.11 C

ATOM 12451 CB SER D 17 60.826 55.185 72.839 1.00 53.56 C

ATOM 12454 OG SER D 17 61.347 53.954 73.336 1.00 55.78 O

ATOM 12456 C SER D 17 59.885 55.054 75.152 1.00 50.62 C

ATOM 12457 O SER D 17 60.571 54.565 75.997 1.00 53.47 O

ATOM 12458 N LEU D 18 58.624 54.752 75.101 1.00 46.73 N

ATOM 12460 CA LEU D 18 57.978 53.917 76.046 1.00 44.77 C

ATOM 12462 CB LEU D 18 56.567 54.511 76.298 1.00 42.30 C

ATOM 12465 CG LEU D 18 55.563 53.620 76.986 1.00 40.07 C

ATOM 12467 CDl LEU D 18 56.090 53.066 78.283 1 .00 41.41 C

ATOM 12471 CD2 LEU D 18 54.332 54.437 77.255 1.00 41.25 C

ATOM 12475 C LEU D 18 57.806 52.599 75.327 1.00 43.93 C

ATOM 12476 O LEU D 18 57.148 52.565 74.292 1.00 42.76 O

ATOM 12477 N SER D 19 58.323 51.506 75.879 1.00 44.90 N

ATOM 12479 CA SER D 19 58.085 50.145 75.341 1.00 43.56 C

ATOM 12481 CB SER D 19 59.401 49.524 74.816 1.00 46.48 C

ATOM 12484 OG SER D 19 59.933 50.140 73.634 1.00 46.71 O

ATOM 12486 C SER D 19 57.448 49.240 76.426 1.00 42.19 C

ATOM 12487 O SER D 19 57.952 49.152 77.562 00 44.56 O

ATOM 12488 N ILE D 20 56.343 48.596 76.071 1.00 39.20 N

ATOM 12490 CA ILE D 20 55.610 47.698 76.923 1.00 38.53 C

ATOM 12492 CB ILE D 20 54.240 48.329 77.293 1.00 37.18 C

ATOM 12494 CGl ILE D 20 54.377 49.567 78.173 1.00 37.34 C

ATOM 12497 CDl ILE D 20 53.211 50.449 78.017 1.00 39.17 C

ATOM 12501 CG2 ILE D 20 53.280 47.309 78.017 00 37.55 C

ATOM 12505 C ILE D 20 55.324 46.437 76.164 00 38.06 C

ATOM 12506 O ILE D 20 54.932 46.471 75.000 00 36.64 O

ATOM 12507 N THR D 21 55.441 45.303 76.835 00 40.37 N

ATOM 12509 CA THR D 21 55.088 44.001 76.249 00 41.04 C

ATOM 12511 CB THR D 21 56.261 43.068 76.450 1.00 43.74 C ATOM 12513 OGl THR D 21 57.415 43.589 75.748 1.00 46.48 O

ATOM 12515 CG2 THR D 21 55.958 41.774 75.812 1.00 45.01 C

ATOM 12519 C THR D 21 53.813 43.430 76.933 1.00 40.58 C

ATOM 12520 O THR D 21 53.626 43.567 78.162 1.00 41.40 O

ATOM 12521 N CYS D 22 52.939 42.816 76.145 1.00 39.61 N

ATOM 12523 CA CYS D 22 51.711 42.179 76.631 1.00 39.65 C

ATOM 12525 CB CYS D 22 50.514 42.703 75.891 1.00 36.18 C

ATOM 12528 SG CYS D 22 48.888 42.439 76.557 00 40.37 S

ATOM 12529 C CYS D 22 51.943 40.719 76.274 00 41.94 C

ATOM 12530 O CYS D 22 51.961 40.359 75.089 00 42.48 O

ATOM 12531 N THR D 23 52.199 39.891 77.285 00 43.68 N

ATOM 12533 CA THR D 23 52.093 38.468 77.096 00 45.36 C

ATOM 12535 CB THR D 23 53.107 37.752 77.925 00 48.80 C

ATOM 12537 OGl THR D 23 54.348 38.483 77.823 00 53.25 O

ATOM 12539 CG2 THR D 23 53.391 36.405 77.328 00 48.29 C

ATOM 12543 C THR D 23 50.749 37.970 77.417 00 44.01 C

ATOM 12544 O THR D 23 50.309 38.115 78.469 00 45.58 O

ATOM 12545 N VAL D 24 50.189 37.240 76.505 00 44.18 N

ATOM 12547 CA VAL D 24 48.801 36.874 76.441 00 43.47 C

ATOM 12549 CB VAL D 24 48.356 37.223 74.983 00 41.96 C

ATOM 12551 CGl VAL D 24 47.387 36.320 74.500 1.00 46.10 C

ATOM 12555 CG2 VAL D 24 47.785 38.612 74.857 1.00 38.96 C

ATOM 12559 C VAL D 24 48.716 35.342 76.633 1.00 45.93 C

ATOM 12560 O VAL D 24 49.555 34.625 76.140 00 47.90 O

ATOM 12561 N SER D 25 47.696 34.840 77.320 00 46.33 N

ATOM 12563 CA SER D 25 47.435 33.388 77.384 00 48.67 C

ATOM 12565 CB SER D 25 48.043 32.805 78.617 1.00 51.18 C

ATOM 12568 OG SER D 25 47.357 33.326 79.724 1.00 50.94 O

ATOM 12570 C SER D 25 45.932 33.060 77.394 .00 47.97 C

ATOM 12571 O SER D 25 45.123 33.821 77.850 ,00 46.72 O

ATOM 12572 N GLY D 26 45.566 31.903 76.896 ,00 49.61 N

ATOM 12574 CA GLY D 26 44.195 31.497 76.922 ,00 49.63 C

ATOM 12577 C GLY D 26 43.485 31.917 75.682 00 47.39 C

ATOM 12578 O GLY D 26 42.289 31.683 75.579 00 48.65 O

ATOM 12579 N PHE D 27 44.175 32.578 74.766 00 44.85 N

ATOM 12581 CA PHE D 27 43.678 32.695 73.407 00 42.48 C

ATOM 12583 CB PHE D 27 42.750 33.823 73.310 ,00 38.91 C

ATOM 12586 CG PHE D 27 43.398 35.137 73.470 ,00 37.97 C

ATOM 12587 CDl PHE D 27 43.723 35.946 72.327 .00 36.52 C

ATOM 12589 CEl PHE D 27 44.286 37.244 72.465 .00 32.40 C

ATOM 12591 CZ PHE D 27 44.529 37.730 73.713 .00 33.39 C

ATOM 12593 CE2 PHE D 27 44.200 36.928 74.876 1.00 36.37 C

ATOM 12595 CD2 PHE D 27 43.631 35.636 74.733 1.00 37.60 C

ATOM 12597 C PHE D 27 44.849 32.968 72.521 1.00 42.29 C

ATOM 12598 O PHE D 27 45.885 33.253 73.043 00 43.18 O

ATOM 12599 N SER D 28 44.701 32.894 71.199 00 41.48 N

ATOM 12601 CA SER D 28 45.787 33.229 70.284 00 41.06 C

ATOM 12603 CB SER D 28 46.052 32.076 69.303 00 43.62 C

ATOM 12606 OG SER D 28 45.379 32.165 68.103 00 42.29 O

ATOM 12608 C SER D 28 45.579 34.557 69.592 00 38.22 C

ATOM 12609 O SER D 28 44.467 34.940 69.333 00 36.54 O

ATOM 12610 N LEU D 29 46.675 35.275 69.369 00 38.34 N

ATOM 12612 CA LEU D 29 46.673 36.543 68.643 00 36.43 C

ATOM 12614 CB LEU D 29 48.007 37.269 68.769 00 35.93 C

ATOM 12617 CG LEU D 29 48.340 37.596 70.229 00 37.34 C

ATOM 12619 CDl LEU D 29 49.853 37.698 70.436 00 42.57 C

ATOM 12623 CD2 LEU D 29 47.767 38.823 70.769 00 35.50 C

ATOM 12627 C LEU D 29 46.360 36.329 67.182 00 36.97 C

ATOM 12628 O LEU D 29 46.087 37.243 66.425 00 36.62 O

ATOM 12629 N THR D 30 46.351 35.089 66.796 00 39.55 N

ATOM 12631 CA THR D 30 45.918 34.679 65.473 00 39.97 C

ATOM 12633 CB THR D 30 46.294 33.210 65.329 00 43.13 C

ATOM 12635 OGl THR D 30 47.406 33.151 64.447 00 45.16 O

ATOM 12637 CG2 THR D 30 45.192 32.267 64.762 1.00 43.76 C

ATOM 12641 C THR D 30 44.454 34.936 65.221 00 38.74 C

ATOM 12642 O THR D 30 44.112 35.136 64.063 00 39.61 O

ATOM 12643 N ASN D 31 43.611 34.983 66.267 00 37.45 N

ATOM 12645 CA ASN D 31 42.163 35.188 66.094 1.00 36.67 C ATOM 12647 CB ASN D 31 41.384 34.034 66.706 .00 38 .21 C

ATOM 12650 CG ASN D 31 41.839 32.691 66.202 .00 40. 54 C

ATOM 12651 ODl ASN D 31 42.034 32.490 64.993 .00 41. 36 O

ATOM 12652 ND2 ASN D 31 42.022 31.763 67.125 .00 40. 98 N

ATOM 12655 C ASN D 31 41.563 36.434 66.711 .00 34 . 82 C

ATOM 12656 O ASN D 31 40.386 36.809 66.403 .00 34 . 97 O

ATOM 12657 N TYR D 32 42.328 37.047 67.606 .00 33. 79 N

ATOM 12659 CA TYR D 32 41.897 38.238 68.386 .00 31.32 C

ATOM 12661 CB TYR D 32 41.680 37.931 69.881 .00 30. 94 C

ATOM 12664 CG TYR D 32 40.436 37.197 70.158 .00 31.75 C

ATOM 12665 CDl TYR D 32 40.437 35.834 70.261 .00 35. 96 C

ATOM 12667 CEl TYR D 32 39.263 35.109 70.544 .00 37 . 48 C

ATOM 12669 CZ TYR D 32 38.076 35.762 70.634 .00 38.25 C

ATOM 12670 OH TYR D 32 36.944 35.006 70.814 .00 42.78 O

ATOM 12672 CE2 TYR D 32 38.032 37.152 70.457 .00 36. 56 C

ATOM 12674 CD2 TYR D 32 39.225 37.857 70.249 .00 33.48 C

ATOM 12676 C TYR D 32 42.934 39.293 68.222 .00 29. 57 C

ATOM 12677 O TYR D 32 44.098 38.983 68.095 .00 32. 81 O

ATOM 12678 N GLY D 33 42.505 40.521 68.175 .00 27.55 N

ATOM 12680 CA GLY D 33 43.339 41.698 68.179 .00 27 . 54 C

ATOM 12683 C GLY D 33 43.622 42.083 69.643 .00 28 .10 C

ATOM 12684 O GLY D 33 42.841 41.699 70.478 .00 28 . 48 O

ATOM 12685 N VAL D 34 44.747 42.753 69.946 .00 28 . 42 N

ATOM 12687 CA VAL D 34 44.978 43.335 71.246 .00 28 .37 C

ATOM 12689 CB VAL D 34 46.329 42.870 71.774 .00 29.29 C

ATOM 12691 CGl VAL D 34 46.618 43.435 73.133 .00 29. 09 C

ATOM 12695 CG2 VAL D 34 46.332 41.434 71.903 .00 31. 00 C

ATOM 12699 C VAL D 34 44.958 44.866 71.101 .00 28.37 C

ATOM 12700 O VAL D 34 45.624 45.432 70.231 .00 28 . 84 O

ATOM 12701 N HIS D 35 44.195 45.528 71.940 .00 28.35 N

ATOM 12703 CA HIS D 35 44.057 46.977 71.908 .00 29. 07 C

ATOM 12705 CB HIS D 35 42.582 47.405 72.135 .00 28. 80 C

ATOM 12708 CG HIS D 35 41.629 46.857 71.124 .00 28. 13 C

ATOM 12709 NDl HIS D 35 41.245 47.557 70.018 .00 28 . 65 N

ATOM 12711 CEl HIS D 35 40.387 46.852 69.309 .00 28.35 C

ATOM 12713 NE2 HIS D 35 40.220 45.689 69.902 .00 29.20 N

ATOM 12715 CD2 HIS D 35 40.962 45.687 71.062 .00 30.52 C

ATOM 12717 C HIS D 35 44.914 47.588 72.996 .00 30. 05 C

ATOM 12718 O HIS D 35 45.252 46.902 73.960 .00 31. 00 O

ATOM 12719 N TRP D 36 45.191 48.891 72.888 .00 30.37 N

ATOM 12721 CA TRP D 36 45.968 49.637 73.896 .00 30.27 C

ATOM 12723 CB TRP D 36 47.309 50.002 73.310 .00 30. 97 C

ATOM 12726 CG TRP D 36 48.150 48.741 73.152 .00 33.79 C

ATOM 12727 CDl TRP D 36 48.170 47.889 72.086 .00 35. 19 C

ATOM 12729 NEl TRP D 36 49.026 46.835 72.340 .00 35. 82 N

ATOM 12731 CE2 TRP D 36 49.551 46.981 73.589 .00 34 . 05 C

ATOM 12732 CD2 TRP D 36 49.040 48.169 74.124 .00 33. 66 C

ATOM 12733 CE3 TRP D 36 49.467 48.562 75.374 .00 33.15 C

ATOM 12735 CZ3 TRP D 36 50.354 47.796 76.024 .00 37 . 51 C

ATOM 12737 CH2 TRP D 36 50.881 46.636 75.451 00 38.07 C

ATOM 12739 CZ2 TRP D 36 50.470 46.216 74.235 1.00 37 .73 C

ATOM 12741 C TRP D 36 45.246 50.892 74.309 00 30 . 62 C

ATOM 12742 O TRP D 36 44.780 51.687 73.485 00 31. 69 O

ATOM 12743 N VAL D 37 45.089 51.077 75.591 00 30.38 N

ATOM 12745 CA VAL D 37 44.250 52.184 76.057 00 30. 87 C

ATOM 12747 CB VAL D 37 42.965 51.664 76.601 00 30. 04 C

ATOM 12749 CGl VAL D 37 42.249 52.681 77.266 00 29.29 C

ATOM 12753 CG2 VAL D 37 42.196 51.029 75.509 00 29. 91 C

ATOM 12757 C VAL D 37 45.001 52.685 77.207 00 32. 03 C

ATOM 12758 O VAL D 37 45.581 51.865 77.898 00 33. 02 O

ATOM 12759 N ARG D 38 44.997 53.987 77.438 00 32. 94 N

ATOM 12761 CA ARG D 38 45.661 54.526 78.606 00 34 .28 C

ATOM 12763 CB ARG D 38 46.875 55.319 78.163 1. 00 35.74 C

ATOM 12766 CG ARG D 38 46.557 56.678 77.574 1. 00 36. 42 C

ATOM 12769 CD ARG D 38 47.776 57.442 77.251 1. 00 36.01 C

ATOM 12772 NE ARG D 38 47.459 58.672 76.558 00 38 .09 N

ATOM 12774 CZ ARG D 38 48.345 59.511 76.121 00 36.79 C

ATOM 12775 NHl ARG D 38 49.623 59.276 76.303 1. 00 39. 89 N ATOM 12778 NH2 ARG D 38 47.960 60.562 75.501 1.00 38.50 N

ATOM 12781 C ARG D 38 44.763 55.369 79.527 1.00 34.80 C

ATOM 12782 O ARG D 38 43.781 55.900 79.125 1.00 33.76 O

ATOM 12783 N GLN D 39 45.159 55.528 80.755 1.00 35.60 N

ATOM 12785 CA GLN D 39 44.335 56.277 81.633 1.00 38.73 C

ATOM 12787 CB GLN D 39 43.724 55.284 82.598 1.00 39.56 C

ATOM 12790 CG GLN D 39 42.743 55.887 83.573 1.00 41.47 C

ATOM 12793 CD GLN D 39 42.015 54.861 84.346 1.00 40.76 C

ATOM 12794 OEl GLN D 39 42.588 53.843 84.731 1.00 40.61 O

ATOM 12795 NE2 GLN D 39 40.736 55.120 84.599 1.00 45.06 N

ATOM 12798 C GLN D 39 45.148 57.376 82.371 1.00 41.44 C

ATOM 12799 O GLN D 39 46.199 57.117 82.951 1.00 41.23 O

ATOM 12800 N SER D 40 44.701 58.612 82.294 1.00 43.95 N

ATOM 12802 CA SER D 40 45.297 59.665 83.117 1.00 48.33 C

ATOM 12804 CB SER D 40 45.996 60.801 82.338 1.00 49.57 C

ATOM 12807 OG SER D 40 45.266 61.127 81.159 1.00 48.49 O

ATOM 12809 C SER D 40 44.162 60.222 83.917 1.00 51.39 C

ATOM 12810 O SER D 40 43.005 60.374 83.420 1.00 53.29 O

ATOM 12811 N PRO D 41 44.470 60.547 85.153 1.00 53.68 N

ATOM 12812 CA PRO D 41 43.423 60.996 86.069 1.00 57.08 C

ATOM 12814 CB PRO D 41 44.192 61.252 87.364 1.00 58.57 C

ATOM 12817 CG PRO D 41 45.528 61.522 86.889 1.00 57.21 C

ATOM 12820 CD PRO D 41 45.811 60.620 85.736 1.00 53.85 C

ATOM 12823 C PRO D 41 42.753 62.260 85.443 1.00 59.94 C

ATOM 12824 O PRO D 41 41.491 62.335 85.416 1.00 60.69 O

ATOM 12825 N GLY D 42 43.616 63.113 84.835 1.00 61.45 N

ATOM 12827 CA GLY D 42 43.269 64.364 84.131 1.00 64.05 C

ATOM 12830 C GLY D 42 42.483 64.364 82.805 1.00 63.41 C

ATOM 12831 O GLY D 42 41.364 64.858 82.825 1.00 65.45 O

ATOM 12832 N LYS D 43 43.023 63.893 81.661 1.00 60.97 N

ATOM 12834 CA LYS D 43 42.118 63.505 80.546 1.00 59.80 C

ATOM 12836 CB LYS D 43 42.851 63.131 79.232 1.00 57.52 C

ATOM 12843 C LYS D 43 41.186 62.352 81.078 1.00 58.39 C

ATOM 12844 O LYS D 43 40.305 62.593 82.000 1.00 63.11 O

ATOM 12845 N GLY D 44 41.315 61.144 80.548 1.00 53.00 N

ATOM 12847 CA GLY D 44 40.557 60.047 81.120 1.00 51.14 C

ATOM 12850 C GLY D 44 41.027 58.728 80.530 1.00 47.33 C

ATOM 12851 O GLY D 44 42.277 58.557 80.366 1.00 46.03 O

ATOM 12852 N LEϋ D 45 40.088 57.808 80.217 1.00 44.05 N

ATOM 12854 CA LEU D 45 40.455 56.553 79.559 1.00 40.18 C

ATOM 12856 CB LEU D 45 39.386 55.575 79.824 1.00 39.67 C

ATOM 12859 CG LEU D 45 39.601 54.171 80.329 1.00 38.63 C

ATOM 12861 CDl LEU D 45 40.898 53.853 80.863 1.00 37.61 C

ATOM 12865 CD2 LEU D 45 38.510 54.020 81.401 1.00 42.06 C

ATOM 12869 C LEU D 45 40.553 56.808 78.075 1.00 38.78 C

ATOM 12870 O LEU D 45 39.585 57.217 77.474 1.00 42.37 O

ATOM 12871 N GLU D 46 41.683 56.616 77.442 1.00 36.39 N

ATOM 12873 CA GLU D 46 41.756 56.917 76.023 1.00 36.08 C

ATOM 12875 CB GLU D 46 42.482 58.195 75.876 1.00 38.06 C

ATOM 12878 CG GLU D 46 42.640 58.660 74.466 1.00 43.17 C

ATOM 12881 CD GLU D 46 43.757 59.721 74.236 1.00 49.47 C

ATOM 12882 OEl GLU D 46 44.654 59.993 75.192 1.00 44.91 O

ATOM 12883 OE2 GLU D 46 43.686 60.248 73.037 1.00 46.97 O

ATOM 12884 C GLU D 46 42.359 55.793 75.169 1.00 32.98 C

ATOM 12885 O GLU D 46 43.347 55.226 75.508 1.00 31.48 O

ATOM 12886 N TRP D 47 41.679 55.438 74.096 1.00 32.53 N

ATOM 12888 CA TRP D 47 42.154 54.391 73.191 1.00 32.16 C

ATOM 12890 CB TRP D 47 41.001 53.746 72.467 1.00 31.08 C

ATOM 12893 CG TRP D 47 41.254 52.697 71.439 1.00 30.69 C

ATOM 12894 CDl TRP D 47 41.205 51.356 71.611 1.00 30.28 C

ATOM 12896 NEl TRP D 47 41.413 50.701 70.416 1.00 29.31 N

ATOM 12898 CE2 TRP D 47 41.587 51.627 69.432 1.00 29.06 C

ATOM 12899 CD2 TRP D 47 41.481 52.897 70.034 1.00 33.41 C

ATOM 12900 CE3 TRP D 47 41.626 54.035 69.212 1.00 36.15 C

ATOM 12902 CZ3 TRP D 47 41.836 53.864 67.825 1.00 32.52 C

ATOM 12904 CH2 TRP D 47 41.916 52.607 67.285 1.00 30.16 C

ATOM 12906 CZ2 TRP D 47 41.785 51.466 68.079 1.00 29.39 C

ATOM 12908 C TRP D 47 43.269 54.825 72.197 1.00 32.70 C ATOM 12909 O TRP D 47 43.190 55.885 71.523 .00 32 . 87 O

ATOM 12910 N LEU D 48 44.322 53.995 72.178 .00 31.73 N

ATOM 12912 CA LEU D 48 45.556 54.317 71.463 .00 32 . 99 C

ATOM 12914 CB LEU D 48 46.776 53.933 72.280 .00 32. 64 C

ATOM 12917 CG LEU D 48 46.758 54.648 73.611 .00 32 . 13 C

ATOM 12919 CDl LEU D 48 47.957 54.186 74.392 .00 32 . 17 C

ATOM 12923 CD2 LEU D 48 46.771 56.119 73.414 .00 32 .53 C

ATOM 12927 C LEU D 48 45.631 53.665 70.121 .00 32 .70 C

ATOM 12928 O LEU D 48 45.921 54.298 69.140 .00 32 .71 O

ATOM 12929 N GLY D 49 45.363 52.376 70.092 .00 32.34 N

ATOM 12931 CA GLY D 49 45.225 51.704 68.809 .00 32 . 63 C

ATOM 12934 C GLY D 49 45.081 50.210 68.962 .00 31. 13 C

ATOM 12935 O GLY D 49 44.752 49.728 70.032 .00 30.55 O

ATOM 12936 N VAL D 50 45.357 49.499 67.880 .00 30. 69 N

ATOM 12938 CA VAL D 50 45.234 48.071 67.858 .00 29. 69 C

ATOM 12940 CB VAL D 50 43.921 47.569 67.214 .00 30.33 C

ATOM 12942 CGl VAL D 50 43.191 46.659 68.168 .00 29. 69 C

ATOM 12946 CG2 VAL D 50 43.087 48.640 66.687 .00 30. 44 C

ATOM 12950 C VAL D 50 46.227 47.452 66.954 .00 29. 44 C

ATOM 12951 O VAL D 50 46.492 47.957 65.895 1.00 28. 43 O

ATOM 12952 N ILE D 51 46.704 46.296 67.352 1.00 29. 83 N

ATOM 12954 CA ILE D 51 47.217 45.344 66.382 1.00 31. 60 C

ATOM 12956 CB ILE D 51 48.621 44.854 66.705 1.00 32.32 C

ATOM 12958 CGl ILE D 51 49.185 44.059 65.511 1.00 36.70 C

ATOM 12961 CDl ILE D 51 50.707 43.620 65.590 1.00 32 . 82 C

ATOM 12965 CG2 ILE D 51 48.644 43.931 67.879 .00 32 .72 C

ATOM 12969 C ILE D 51 46.179 44.218 66.317 .00 31. 06 C

ATOM 12970 O ILE D 51 46.002 43.445 67.231 .00 30.75 O

ATOM 12971 N TRP D 52 45.429 44.247 65.242 .00 31. 60 N

ATOM 12973 CA TRP D 52 44.467 43.230 64.869 .00 31.36 C

ATOM 12975 CB TRP D 52 43.712 43.639 63.636 .00 30. 90 C

ATOM 12978 CG TRP D 52 42.953 44.914 63.709 .00 29. 08 C

ATOM 12979 CDl TRP D 52 43.219 46.097 63.033 .00 28 . 04 C

ATOM 12981 NEl TRP D 52 42.243 47.006 63.289 1.00 26. 54 N

ATOM 12983 CE2 TRP D 52 41.321 46.397 64.086 1.00 25. 66 C

ATOM 12984 CD2 TRP D 52 41.738 45.097 64.333 .00 26. 15 C

ATOM 12985 CE3 TRP D 52 40.927 44.278 65.103 .00 29. 06 C

ATOM 12987 CZ3 TRP D 52 39.779 44.803 65.625 .00 26. 64 C

ATOM 12989 CH2 TRP D 52 39.410 46.068 65.353 .00 27 .20 C

ATOM 12991 CZ2 TRP D 52 40.166 46.880 64.583 .00 28. 98 C

ATOM 12993 C TRP D 52 45.108 41.895 64.531 .00 32 . 27 C

ATOM 12994 O TRP D 52 46.307 41.779 64.320 .00 32. 72 O

ATOM 12995 N SER D 53 44.227 40.915 64.488 .00 32 .74 N

ATOM 12997 CA SER D 53 44.580 39.525 64.425 1.00 34 . 75 C

ATOM 12999 CB SER D 53 43.298 38.681 64.426 1.00 35. 90 C

ATOM 13002 OG SER D 53 42.764 38.516 63.151 1.00 37 .74 O

ATOM 13004 C SER D 53 45.454 39.204 63.274 00 35.30 C

ATOM 13005 O SER D 53 46.503 38.646 63.451 00 37 .19 O

ATOM 13006 N GLY D 54 45.092 39.637 62.083 1.00 35. 49 N

ATOM 13008 CA GLY D 54 45.992 39.425 60.943 00 35. 48 C

ATOM 13011 C GLY D 54 47.220 40.303 60.835 00 34 .39 C

ATOM 13012 O GLY D 54 47.807 40.343 59.768 00 36.25 O

ATOM 13013 N GLY D 55 47.614 40.991 61.899 00 32 .23 N

ATOM 13015 CA GLY D 55 48.901 41.684 61.913 00 33. 48 C

ATOM 13018 C GLY D 55 48.859 43.138 61.531 00 33.28 C

ATOM 13019 O GLY D 55 49.752 43.862 61.701 00 33.23 O

ATOM 13020 N ASN D 56 47.752 43.574 61.012 00 33. 55 N

ATOM 13022 CA ASN D 56 47.664 44.924 60.574 00 35. 11 C

ATOM 13024 CB ASN D 56 46.626 45.025 59.499 00 34.70 C

ATOM 13027 CG ASN D 56 45.305 44.633 59.959 00 35.37 C

ATOM 13028 ODl ASN D 56 44.385 45.451 59.883 00 40 .28 O

ATOM 13029 ND2 ASN D 56 45.122 43.357 60.343 00 36.56 N

ATOM 13032 C ASN D 56 47.347 45.795 61.765 00 34 .36 C

ATOM 13033 O ASN D 56 46.820 45.268 62.750 00 33 .78 O

ATOM 13034 N THR D 57 47.669 47.100 61.710 00 34 . 41 N

ATOM 13036 CA THR D 57 47.319 47.969 62.842 00 32.78 C

ATOM 13038 CB THR D 57 48.563 48.487 63.562 00 32. 50 C

ATOM 13040 OGl THR D 57 49.303 49.334 62.711 1 . 00 34 .26 O ATOM 13042 CG2 THR D 57 49.505 47.392 63.858 1.00 33.15 C

ATOM 13046 C THR D 57 46.377 49.127 62.532 1.00 32.96 C

ATOM 13047 O THR D 57 46.016 49.401 61.417 1.00 34.56 O

ATOM 13048 N ASP D 58 45.957 49.794 63.572 1.00 32.56 N

ATOM 13050 CA ASP D 58 45.262 51.043 63.418 1.00 33.53 C

ATOM 13052 CB ASP D 58 43.805 50.801 63.352 1.00 32.81 C

ATOM 13055 CG ASP D 58 43.086 51.930 62.805 1.00 35.44 C

ATOM 13056 ODl ASP D 58 43.702 52.786 62.201 1.00 39.99 O

ATOM 13057 OD2 ASP D 58 41.850 52.052 62.880 1 00 44.18 O

ATOM 13058 C ASP D 58 45.555 51.858 64.639 1 00 34.20 C

ATOM 13059 O ASP D 58 45.601 51.348 65.789 1 00 33.15 O

ATOM 13060 N TYR D 59 45.757 53.139 64.413 1 00 36.15 N

ATOM 13062 CA TYR D 59 46.178 54.024 65.491 1 00 35.91 C

ATOM 13064 CB TYR D 59 47.573 54.426 65.247 1 00 36.57 C

ATOM 13067 CG TYR D 59 48.572 53.328 65.088 1 00 37.04 C

ATOM 13068 CDl TYR D 59 49.590 53.425 64.103 1 00 40.41 C

ATOM 13070 CEl TYR D 59 50.555 52.505 63.961 1 00 38.26 C

ATOM 13072 CZ TYR D 59 50.592 51.439 64.807 1 00 36.55 C

ATOM 13073 OH TYR D 59 51.546 50.524 64.623 1 00 38.64 O

ATOM 13075 CE2 TYR D 59 49.668 51.275 65.780 1 00 36.05 C

ATOM 13077 CD2 TYR D 59 48.620 52.260 65.935 1.00 36.55 C

ATOM 13079 C TYR D 59 45.335 55.284 65.529 1 .00 36.81 C

ATOM 13080 O TYR D 59 45.092 55.899 64.524 1.00 38.49 O

ATOM 13081 N ASN D 60 44.888 55.660 66.710 1.00 36.57 N

ATOM 13083 CA ASN D 60 44.107 56.894 66.906 1.00 38.17 C

ATOM 13085 CB ASN D 60 43.885 57.030 68.383 1.00 37.59 C

ATOM 13088 CG ASN D 60 42.742 57.873 68.742 1.00 39.27 C

ATOM 13089 ODl ASN D 60 42.025 58.492 67.928 1.00 42.52 O

ATOM 13090 ND2 ASN D 60 42.533 57.895 70.029 1.00 40.55 N

ATOM 13093 C ASN D 60 44.905 58.075 66.418 1.00 39.85 C

ATOM 13094 O ASN D 60 46.085 58.121 66.619 1.00 40.65 O

ATOM 13095 N THR D 61 44.255 59.004 65.783 1.00 41.38 N

ATOM 13097 CA THR D 61 44.885 60.081 65.089 1.00 45.06 C

ATOM 13099 CB THR D 61 43.838 61.144 64.787 00 48.42 C

ATOM 13101 OGl THR D 61 42.731 60.516 64.121 1.00 47.87 O

ATOM 13103 CG2 THR D 61 44.366 62.233 63.789 1.00 52.40 C

ATOM 13107 C THR D 61 46.027 60.733 65.763 1.00 46.36 C

ATOM 13108 O THR D 61 47.011 60.937 65.152 1.00 48.83 O

ATOM 13109 N PRO D 62 45.936 61.148 66.995 1.00 47.67 N

ATOM 13110 CA PRO D 62 47.106 61.814 67.621 1.00 49.35 C

ATOM 13112 CB PRO D 62 46.538 62.388 68.924 1.00 49.55 C

ATOM 13115 CG PRO D 62 45.387 61.448 69.263 1.00 47.57 C

ATOM 13118 CD PRO D 62 44.769 61.089 67.900 1.00 47.33 C

ATOM 13121 C PRO D 62 48.301 60.936 67.935 00 47.56 C

ATOM 13122 O PRO D 62 49.297 61.412 68.435 00 49.85 O

ATOM 13123 N PHE D 63 48.225 59.660 67.661 00 45.89 N

ATOM 13125 CA PHE D 63 49.354 58.776 67.922 00 45.48 C

ATOM 13127 CB PHE D 63 48.991 57.694 69.022 00 42.86 C

ATOM 13130 CG PHE D 63 48.348 58.264 70.261 00 41.77 C

ATOM 13131 CDl PHE D 63 46.985 58.211 70.441 00 37.08 C

ATOM 13133 CEl PHE D 63 46.398 58.790 71.575 00 38.67 C

ATOM 13135 CZ PHE D 63 47.145 59.418 72.527 00 37.15 C

ATOM 13137 CE2 PHE D 63 48.487 59.515 72.346 00 41.21 C

ATOM 13139 CD2 PHE D 63 49.109 58.935 71.211 00 41.81 C

ATOM 13141 C PHE D 63 49.802 58.127 66.601 00 46.08 C

ATOM 13142 O PHE D 63 50.622 57.230 66.587 00 46.42 O

ATOM 13143 N THR D 64 49.300 58.568 65.480 00 47.62 N

ATOM 13145 CA THR D 64 49.712 57.961 64.240 00 49.13 C

ATOM 13147 CB THR D 64 48.972 58.633 63.160 00 51.36 C

ATOM 13149 OGl THR D 64 47.638 58.085 63.156 00 50.94 O

ATOM 13151 CG2 THR D 64 49.591 58.313 61.782 00 54.91 C

ATOM 13155 C THR D 64 51.210 58.114 63.990 00 52.42 C

ATOM 13156 O THR D 64 51.907 57.193 63.532 00 53.42 O

ATOM 13157 N SER D 65 51.737 59.289 64.303 00 54.78 N

ATOM 13159 CA SER D 65 53.053 59.604 63.833 00 56.59 C

ATOM 13161 CB SER D 65 53.251 61.158 63.765 00 60.91 C

ATOM 13164 OG SER D 65 53.283 61.827 65.066 00 60.68 O

ATOM 13166 C SER D 65 54.083 58.943 64.716 1.00 54.95 C ATOM 13167 OO SER D 65 55.308 59.151 64.511 1.00 58.96 O ATOM 13168 N N ARG D 66 53.650 58.240 65.753 1.00 50.49 N ATOM 13170 C CAA ARG D 66 54.617 57.976 66.852 1.00 50.01 C ATOM 13172 C CBB ARG D 66 54.716 59.163 67.832 1.00 50.28 C ATOM 13175 C CGG ARG D 66 53.473 59.338 68.681 1.00 49.71 C ATOM 13178 C CDD ARG D 66 53.310 60.748 69.279 1.00 52.47 C ATOM 13181 N NEE ARG D 66 53.856 60.823 70.640 1.00 51.78 N ATOM 13183 C CZZ ARG D 66 53.150 60.998 71.750 1.00 50.52 C ATOM 13184 NHl ARG D 66 51.848 61.166 71.744 1.00 52.35 N ATOM 13187 NH2 ARG D 66 53.760 61.064 72.902 1.00 52.82 N ATOM 13190 C C ARG D 66 54.356 56.697 67.597 1.00 46.69 C ATOM 13191 O O ARG D 66 55.145 56.247 68.434 1.00 46.16 O ATOM 13192 N N LEO D 67 53.265 56.067 67.250 1.00 44.55 N ATOM 13194 C CAA LEU D 67 52.930 54.840 67.913 1.00 42.69 C ATOM 13196 C CBB LEU D 67 51.444 54.918 68.365 1.00 40.49 C ATOM 13199 C CGG LEU D 67 50.806 53.736 69.049 1.00 39.68 C ATOM 13201 CDl LEU D 67 51.766 53.114 70.010 1.00 41.91 C ATOM 13205 CD2 LEU D 67 49.535 54.112 69.731 1.00 39.30 C ATOM 13209 C C L LEEUU D D 67 53.301 53.694 66.939 1.00 42.23 C ATOM 13210 O O L LEEUU D D 67 53.187 53.803 65.722 1.00 41.99 O ATOM 13211 N N S SEERR D D 68 53.814 52.615 67.484 1.00 41.73 N ATOM 13213 C CAA S SEERR D D 68 53.956 51.426 66.679 1.00 42.24 C ATOM 13215 C CBB S SEERR D D 68 55.369 51.322 66.097 1.00 44.65 C ATOM 13218 O OGG S SEERR D D 68 56.007 50.216 66.719 1.00 44.64 O ATOM 13220 C C S SEERR D D 68 53.670 50.202 67.537 1.00 40.14 C ATOM 13221 O O S SEERR D D 68 54.406 49.959 68.458 1.00 41.75 O ATOM 13222 N N I ILLEE D D 69 52.646 49.430 67.192 1.00 38.16 N ATOM 13224 C CAA I ILLEE D D 69 52.444 48.115 67.777 1.00 37.76 C ATOM 13226 CB ILE D 69 51.042 47.962 68.094 1.00 35.22 C ATOM 13228 CGl ILE D 69 50.542 49.253 68.763 1.00 35.84 C ATOM 13231 CDl ILE D 69 49.059 49.374 69.024 1.00 34.14 C ATOM 13235 CG2 ILE D 69 50.941 46.834 69.044 1.00 36.27 C ATOM 13239 C C ILE D 69 52.930 46.915 66.909 1.00 39.46 C ATOM 13240 O O ILE D 69 52.799 46.952 65.673 1.00 41.51 O ATOM 13241 N N ASN D 70 53.501 45.877 67.523 1.00 39.23 N ATOM 13243 C CAA ASN D 70 53.977 44.715 66.762 1.00 41.63 C ATOM 13245 C CBB ASN D 70 55.460 44.779 66.533 1.00 44.84 C ATOM 13248 C CGG ASN D 70 55.800 45.718 65.434 1.00 49.17 C ATOM 13249 ODl ASN D 70 55.575 45.399 64.289 1.00 55.81 O ATOM 13250 ND2 ASN D 70 56.256 46.927 65.763 1.00 52.56 N ATOM 13253 C C ASN D 70 53.631 43.453 67.469 1.00 40.86 C ATOM 13254 O O ASN D 70 53.133 43.517 68.548 1.00 40.73 O ATOM 13255 N N LYS D 71 53.824 42.299 66.872 1.00 41.57 N ATOM 13257 C CAA LYS D 71 53.571 41.114 67.652 1.00 41.77 C ATOM 13259 C CBB LYS D 71 52.089 40.784 67.647 1.00 39.31 C ATOM 13262 C CGG LYS D 71 51.532 40.227 66.385 1.00 38.04 C ATOM 13265 C CDD LYS D 71 49.962 40.233 66.402 1.00 37.00 C ATOM 13268 C CEE LYS D 71 49.309 39.359 65.314 1.00 34.15 C ATOM 13271 N NZZ LYS D 71 47.935 39.378 65.457 1.00 32.61 N ATOM 13275 C C LYS D 71 54.304 39.898 67.162 1.00 45.31 C ATOM 13276 O O LYS D 71 54.644 39.819 66.008 1.00 47.02 O ATOM 13277 N N ASP D 72 54.499 38.940 68.061 1.00 46.92 N ATOM 13279 C CAA ASP D 72 54.911 37.579 67.731 1.00 49.86 C ATOM 13281 C CBB ASP D 72 56.252 37.312 68.418 1.00 52.20 C ATOM 13284 C CGG ASP D 72 56.857 36.047 67.966 1.00 58.26 C ATOM 13285 ODl ASP D 72 56.033 35.215 67.531 1.00 59.63 O ATOM 13286 OD2 ASP D 72 58.108 35.774 67.965 1.00 67.49 O ATOM 13287 C C ASP D 72 53.816 36.496 68.102 1.00 48.55 C ATOM 13288 O O ASP D 72 53.706 36.125 69.270 1.00 48.20 O ATOM 13289 N N ASN D 73 53.015 36.002 67.142 1.00 47.65 N ATOM 13291 C CAA ASN D 73 51.975 35.023 67.542 1.00 47.21 C ATOM 13293 C CBB ASN D 73 50.978 34.570 66.476 1.00 45.48 C ATOM 13296 C CGG ASN D 73 50.327 35.684 65.713 1.00 43.16 C ATOM 13297 ODl ASN D 73 49.630 36.539 66.293 1.00 47.44 O ATOM 13298 ND2 ASN D 73 50.408 35.612 64.406 1.00 39.25 N ATOM 13301 C ASN D 73 52.598 33.748 68.083 1.00 51.12 C ATOM 13302 O ASN D 73 51.987 33.107 68.883 1.00 52.43 O ATOM 13303 N SER D 74 53.773 33.318 67.643 1.00 54.87 N ATOM 13305 CA SER D 74 54.397 32.122 68.317 1.00 58.74 C

ATOM 13307 CB SER D 74 55.773 31.817 67.787 1.00 62.13 C

ATOM 13310 OG SER D 74 55.629 31.667 66.404 1.00 65.94 O

ATOM 13312 C SER D 74 54.543 32.307 69.802 1.00 58.18 C

ATOM 13313 O SER D 74 54.129 31.462 70.531 .00 60.18 O

ATOM 13314 N LYS D 75 55.131 33.421 70.238 .00 56.43 N

ATOM 13316 CA LYS D 75 55.368 33.665 71.639 .00 56.60 C

ATOM 13318 CB LYS D 75 56.566 34.600 71.806 .00 57.02 C

ATOM 13321 CG LYS D 75 57.816 33.999 71.324 .00 62.21 C

ATOM 13324 CD LYS D 75 58.969 34.990 71.079 .00 65.08 C

ATOM 13327 CE LYS D 75 60.071 34.308 70.161 .00 69.37 C

ATOM 13330 NZ LYS D 75 61.327 33.664 70.861 .00 75.58 N

ATOM 13334 C LYS D 75 54.153 34.295 72.277 .00 53.67 C

ATOM 13335 O LYS D 75 54.254 34.800 73.361 .00 53.73 O

ATOM 13336 N SER D 76 52.997 34.249 71.621 .00 52.05 N

ATOM 13338 CA SER D 76 51.836 35.122 71.941 .00 48.62 C

ATOM 13340 CB SER D 76 50.739 34.328 72.636 .00 48.74 C

ATOM 13343 OG SER D 76 51.376 33.677 73.649 .00 52.34 O

ATOM 13345 C SER D 76 52.224 36.397 72.744 .00 46.65 C

ATOM 13346 O SER D 76 51.862 36.571 73.915 .00 45.12 O

ATOM 13347 N GLN D 77 52.938 37.285 72.056 .00 45.21 N

ATOM 13349 CA GLN D 77 53.433 38.479 72.656 00 43.66 C

ATOM 13351 CB GLN D 77 54.970 38.339 72.814 1.00 46.88 C

ATOM 13354 CG GLN D 77 55.413 37.830 74.223 1.00 47.53 C

ATOM 13357 CD GLN D 77 56.927 37.700 74.397 1.00 49.35 C

ATOM 13358 OEl GLN D 77 57.662 37.900 73.452 1.00 49.14 O

ATOM 13359 NE2 GLN D 77 57.377 37.335 75.607 1.00 49.80 N

ATOM 13362 C GLN D 77 53.046 39.686 71.801 .00 40.90 C

ATOM 13363 O GLN D 77 53.118 39.637 70.599 .00 39.78 O

ATOM 13364 N VAL D 78 52.621 40.767 72.441 .00 39.44 N

ATOM 13366 CA VAL D 78 52.391 42.018 71.747 .00 38.83 C

ATOM 13368 CB VAL D 78 51.002 42.480 71.899 .00 36.73 C

ATOM 13370 CGl VAL D 78 50.881 43.889 71.317 .00 36.47 C

ATOM 13374 CG2 VAL D 78 50.060 41.533 71.152 .00 36.98 C

ATOM 13378 C VAL D 78 53.269 43.132 72.259 .00 39.68 C

ATOM 13379 O VAL D 78 53.417 43.313 73.430 .00 41.11 O

ATOM 13380 N PHE D 79 53.852 43.887 71.350 .00 41.21 N

ATOM 13382 CA PHE D 79 54.922 44.885 71.657 .00 42.91 C

ATOM 13384 CB PHE D 79 56.198 44.576 70.873 .00 44.00 C

ATOM 13387 CG PHE D 79 56.685 43.209 71.048 .00 44.41 C

ATOM 13388 CDl PHE D 79 56.809 42.361 69.986 .00 44.33 C

ATOM 13390 CEl PHE D 79 57.312 41.097 70.146 .00 44.84 C

ATOM 13392 CZ PHE D 79 57.692 40.655 71.360 1.00 46.86 C

ATOM 13394 CE2 PHE D 79 57.625 41.481 72.428 1.00 47.48 C

ATOM 13396 CD2 PHE D 79 57.110 42.779 72.274 1.00 47.39 C

ATOM 13398 C PHE D 79 54.451 46.315 71.284 1.00 41.27 C

ATOM 13399 O PHE D 79 54.445 46.684 70.135 1.00 41.52 O

ATOM 13400 N PHE D 80 54.052 47.086 72.266 1.00 40.35 N

ATOM 13402 CA PHE D 80 53.562 48.422 72.037 1.00 39.60 C

ATOM 13404 CB PHE D 80 52.521 48.721 73.090 1.00 38.21 C

ATOM 13407 CG PHE D 80 52.216 50.165 73.261 1.00 37.90 C

ATOM 13408 CDl PHE D 80 51.021 50.680 72.821 .00 35.78 C

ATOM 13410 CEl PHE D 80 50.725 51.977 73.032 .00 34.24 C

ATOM 13412 CZ PHE D 80 51.553 52.761 73.706 .00 33.92 C

ATOM 13414 CE2 PHE D 80 52.672 52.283 74.183 .00 37.81 C

ATOM 13416 CD2 PHE D 80 53.045 50.982 73.964 .00 37.72 C

ATOM 13418 C PHE D 80 54.725 49.303 72.235 .00 41.55 C

ATOM 13419 O PHE D 80 55.430 49.157 73.215 .00 42.98 O

ATOM 13420 N LYS D 81 54.956 50.208 71.309 .00 42.00 N

ATOM 13422 CA LYS D 81 56.094 51.126 71.444 .00 43.52 C

ATOM 13424 CB LYS D 81 57.243 50.693 70.573 .00 45.25 C

ATOM 13427 CG LYS D 81 58.519 51.595 70.732 .00 48.35 C

ATOM 13430 CD LYS D 81 59.776 51.198 69.903 .00 49.70 C

ATOM 13433 CE LYS D 81 60.773 52.392 69.816 1.00 53.14 C

ATOM 13436 NZ LYS D 81 62.159 52.008 69.543 1.00 55.94 N

ATOM 13440 C LYS D 81 55.604 52.514 71.033 1.00 43.91 C

ATOM 13441 O LYS D 81 54.940 52.640 69.988 1.00 44.59 O

ATOM 13442 N MET D 82 55.837 53.535 71.861 1.00 44.38 N ATOM 13444 CA MET D 82 55.448 54.904 71.496 1.00 45.09 C

ATOM 13446 CB MET D 82 54.343 55.408 72.393 1.00 44.28 C

ATOM 13449 CG MET D 82 54.024 56.895 72.173 1.00 45.85 C

ATOM 13452 SD MET D 82 52.329 57.187 72.824 .00 47.44 S

ATOM 13453 CE MET D 82 52.586 57.665 74.489 .00 46.84 C

ATOM 13457 C MET D 82 56.604 55.815 71.643 .00 47.35 C

ATOM 13458 O MET D 82 57.299 55.728 72.615 .00 47.79 O

ATOM 13459 N ASN D 83 56.792 56.728 70.704 .00 49.56 N

ATOM 13461 CA ASN D 83 58.009 57.562 70.660 .00 52.90 C

ATOM 13463 CB ASN D 83 58.447 57.777 69.202 .00 55.93 C

ATOM 13466 CG ASN D 83 58.932 56.492 68.511 .00 58.70 C

ATOM 13467 ODl ASN D 83 59.525 55.600 69.150 .00 60.92 O

ATOM 13468 ND2 ASN D 83 58.724 56.428 67.175 .00 62.10 N

ATOM 13471 C ASN D 83 57.828 58.935 71.279 .00 53.16 C

ATOM 13472 O ASN D 83 56.723 59.418 71.428 .00 50.57 O

ATOM 13473 N SER D 84 58.938 59.578 71.592 .00 56.13 N

ATOM 13475 CA SER D 84 58.927 60.981 72.007 1.00 58.85 C

ATOM 13477 CB SER D 84 58.743 61.821 70.818 1.00 60.49 C

ATOM 13480 OG SER D 84 59.650 61.296 69.902 1.00 66.30 O

ATOM 13482 C SER D 84 57.859 61.347 72.991 1.00 57.53 C

ATOM 13483 O SER D 84 56.903 62.028 72.657 1.00 57.77 O

ATOM 13484 N LEU D 85 58.044 60.895 74.219 1.00 56.64 N

ATOM 13486 CA LEU D 85 57.070 61.114 75.227 1.00 55.13 C

ATOM 13488 CB LEU D 85 57.161 60.009 76.274 1.00 53.82 C

ATOM 13491 CG LEU D 85 56.234 58.846 75.910 1.00 50.98 C

ATOM 13493 CDl LEU D 85 56.953 57.991 74.900 1.00 52.48 C

ATOM 13497 CD2 LEU D 85 55.847 58.046 77.151 1.00 49.77 C

ATOM 13501 C LEU D 85 57.320 62.484 75.826 1.00 57.61 C

ATOM 13502 O LEU D 85 58.423 62.985 75.802 1.00 60.21 O

ATOM 13503 N GLN D 86 56.247 63.093 76.298 1.00 56.61 N

ATOM 13505 CA GLN D 86 56.287 64.342 77.012 1.00 58.88 C

ATOM 13507 CB GLN D 86 55.661 65.449 76.174 1.00 60.42 C

ATOM 13510 CG GLN D 86 56.455 65.786 74.922 1.00 62.18 C

ATOM 13513 CD GLN D 86 57.886 66.248 75.220 1.00 64.34 C

ATOM 13514 OEl GLN D 86 58.158 66.968 76.214 1.00 62.43 O

ATOM 13515 NE2 GLN D 86 58.800 65.806 74.377 1.00 62.47 N

ATOM 13518 C GLN D 86 55.487 64.077 78.249 1.00 56.98 C

ATOM 13519 O GLN D 86 55.039 62.988 78.450 1.00 53.19 O

ATOM 13520 N SER D 87 55.323 65.069 79.089 1.00 59.59 N

ATOM 13522 CA SER D 87 54.745 64.812 80.381 1.00 59.57 C

ATOM 13524 CB SER D 87 55.036 65.975 81.289 1.00 63.01 C

ATOM 13527 OG SER D 87 54.389 67.041 80.689 1.00 67.52 O

ATOM 13529 C SER D 87 53.258 64.544 80.272 1.00 57.33 C

ATOM 13530 O SER D 87 52.767 63.721 81.021 1.00 55.78 O

ATOM 13531 N ASN D 88 52.563 65.209 79.329 1.00 58.66 N

ATOM 13533 CA ASN D 88 51.256 64.748 78.718 1.00 56.25 C

ATOM 13535 CB ASN D 88 51.180 65.170 77.247 1.00 57.45 C

ATOM 13538 CG ASN D 88 50.876 66.580 77.067 1.00 62.84 C

ATOM 13539 ODl ASN D 88 50.883 67.306 78.041 1.00 74.09 O

ATOM 13540 ND2 ASN D 88 50.533 67.012 75.831 1.00 63.95 N

ATOM 13543 C ASN D 88 51.038 63.237 78.581 1.00 52.90 C

ATOM 13544 O ASN D 88 49.916 62.814 78.417 1.00 52.43 O

ATOM 13545 N ASP D 89 52.092 62.440 78.501 1.00 51.41 N

ATOM 13547 CA ASP D 89 51.949 61.018 78.388 1.00 49.06 C

ATOM 13549 CB ASP D 89 52.926 60.536 77.355 1.00 49.14 C

ATOM 13552 CG ASP D 89 52.744 61.234 76.046 1.00 51.56 C

ATOM 13553 ODl ASP D 89 51.627 61.127 75.481 1.00 51.32 O

ATOM 13554 OD2 ASP D 89 53.661 61.899 75.486 1.00 54.26 O

ATOM 13555 C ASP D 89 52.113 60.193 79.688 1.00 49.01 C

ATOM 13556 O ASP D 89 52.119 58.945 79.650 1.00 47.85 O

ATOM 13557 N THR D 90 52.206 60.851 80.847 1.00 51.07 N

ATOM 13559 CA THR D 90 52.121 60.112 82.141 1.00 49.85 C

ATOM 13561 CB THR D 90 52.273 61.030 83.288 1.00 51.99 C

ATOM 13563 OGl THR D 90 53.571 61.636 83.183 1.00 57.36 O

ATOM 13565 CG2 THR D 90 52.303 60.281 84.588 1.00 51.56 C

ATOM 13569 C THR D 90 50.773 59.577 82.214 1.00 47.11 C

ATOM 13570 O THR D 90 49.808 60.323 81.988 1.00 47.64 O

ATOM 13571 N ALA D 91 50.695 58.289 82.502 1.00 45.03 N ATOM 13573 CA ALA D 91 49.405 57.551 82.488 .00 42.38 C

ATOM 13575 CB ALA D 91 48.762 57.590 81.130 .00 41.09 C

ATOM 13579 C ALA D 91 49.640 56.147 82.851 .00 40.25 C

ATOM 13580 O ALA D 91 50.767 55.723 82.869 .00 41.74 O

ATOM 13581 N ILE D 92 48.576 55.431 83.165 .00 38.65 N

ATOM 13583 CA ILE D 92 48.616 53.982 83.189 .00 36.52 C

ATOM 13585 CB ILE D 92 47.692 53.500 84.265 .00 37.41 C

ATOM 13587 CGl ILE D 92 48.318 53.873 85.587 .00 39.88 C

ATOM 13590 CDl ILE D 92 47.426 54.065 86.604 .00 43.89 C

ATOM 13594 CG2 ILE D 92 47.526 52.047 84.213 .00 36.13 C

ATOM 13598 C ILE D 92 48.310 53.461 81.803 .00 33.73 C

ATOM 13599 O ILE D 92 47.290 53.775 81.214 .00 32.00 O

ATOM 13600 N TYR D 93 49.248 52.737 81.244 .00 33.28 N

ATOM 13602 CA TYR D 93 49.012 52.153 79.948 .00 32.94 C

ATOM 13604 CB TYR D 93 50.261 52.260 79.101 .00 32.51 C

ATOM 13607 CG TYR D 93 50.564 53.690 78.742 ,00 35.57 C

ATOM 13608 CDl TYR D 93 50.996 54.606 79.683 ,00 38.55 C

ATOM 13610 CEl TYR D 93 51.271 55.942 79.320 .00 40.44 C

ATOM 13612 CZ TYR D 93 51.095 56.353 78.008 00 38.75 C

ATOM 13613 OH TYR D 93 51.301 57.632 77.620 ,00 36.83 O

ATOM 13615 CE2 TYR D 93 50.676 55.468 77.070 ,00 37.22 C

ATOM 13617 CD2 TYR D 93 50.386 54.151 77.450 00 37.91 C

ATOM 13619 C TYR D 93 48.527 50.698 80.099 00 32.47 C

ATOM 13620 O TYR D 93 49.158 49.906 80.771 00 33.93 O

ATOM 13621 N TYR D 94 47.412 50.374 79.461 00 31.81 N

ATOM 13623 CA TYR D 94 46.790 49.071 79.509 00 31.89 C

ATOM 13625 CB TYR D 94 45.316 49.180 79.927 00 31.43 C

ATOM 13628 CG TYR D 94 45.044 49.623 81.317 00 34.26 C

ATOM 13629 CDl TYR D 94 44.722 50.933 81.611 00 34.32 C

ATOM 13631 CEl TYR D 94 44.471 51.333 82.955 00 37.87 C

ATOM 13633 CZ TYR D 94 44.541 50.406 83.981 ,00 40.08 C

ATOM 13634 OH TYR D 94 44.302 50.719 85.322 00 44.06 O

ATOM 13636 CE2 TYR D 94 44.840 49.120 83.681 ,00 39.37 C

ATOM 13638 CD2 TYR D 94 45.065 48.720 82.362 00 37.60 C

ATOM 13640 C TYR D 94 46.766 48.458 78.114 00 31.19 C

ATOM 13641 O TYR D 94 46.595 49.162 77.134 ,00 28.84 O

ATOM 13642 N CYS D 95 46.803 47.114 78.094 00 32.31 N

ATOM 13644 CA CYS D 95 46.343 46.326 76.978 ,00 31.63 C

ATOM 13646 CB CYS D 95 47.407 45.367 76.555 00 32.86 C

ATOM 13649 SG CYS D 95 47.837 44.087 77.682 00 36.32 S

ATOM 13650 C CYS D 95 45.043 45.595 77.229 00 31.81 C

ATOM 13651 O CYS D 95 44.543 45.489 78.338 00 32.84 O

ATOM 13652 N ALA D 96 44.415 45.138 76.170 00 31.66 N

ATOM 13654 CA ALA D 96 43.065 44.613 76.333 00 31.98 C

ATOM 13656 CB ALA D 96 42.067 45.738 76.560 00 31.73 C

ATOM 13660 C ALA D 96 42.610 43.789 75.189 00 31.15 C

ATOM 13661 O ALA D 96 43.109 43.916 74.113 00 30.28 O

ATOM 13662 N ARG D 97 41.644 42.929 75.459 00 31.57 N

ATOM 13664 CA ARG D 97 41.056 42.132 74.424 00 31.04 C

ATOM 13666 CB ARG D 97 41.403 40.657 74.529 00 31.65 C

ATOM 13669 CG ARG D 97 41.364 39.961 73.252 00 30.26 C

ATOM 13672 CD ARG D 97 41.106 38.522 73.380 00 33.63 C

ATOM 13675 NE ARG D 97 39.673 38.270 73.544 00 35.37 N

ATOM 13677 CZ ARG D 97 39.119 37.052 73.723 00 37.21 C

ATOM 13678 NHl ARG D 97 39.855 35.971 73.753 00 39.36 N

ATOM 13681 NH2 ARG D 97 37.797 36.905 73.786 00 38.08 N

ATOM 13684 C ARG D 97 39.632 42.302 74.578 00 30.96 C

ATOM 13685 O ARG D 97 39.130 42.243 75.686 00 31.79 O

ATOM 13686 N ALA D 98 38.981 42.482 73.441 00 30.39 N

ATOM 13688 CA ALA D 98 37.540 42.481 73.374 00 30.35 C

ATOM 13690 CB ALA D 98 37.141 42.731 71.958 00 30.65 C

ATOM 13694 C ALA D 98 36.991 41.140 73.769 00 31.90 C

ATOM 13695 O ALA D 98 37.675 40.141 73.670 00 31.68 O

ATOM 13696 N LEU D 99 35.719 41.124 74.134 1.00 33.49 N

ATOM 13698 CA LEU D 99 34.995 39.875 74.405 1.00 35.36 C

ATOM 13700 CB LEU D 99 33.719 40.195 75.166 1.00 36.53 C

ATOM 13703 CG LEU D 99 32.855 39.064 75.632 1.00 37.57 C

ATOM 13705 CDl LEU D 99 33.465 38.470 76.786 1.00 39.95 C ATOM 13709 CD2 LEU D 99 31.538 39.533 75.980 .00 38.23 C

ATOM 13713 C LEO D 99 34.636 39.123 73.129 .00 34.97 C

ATOM 13714 O LEU D 99 34.376 37.955 73.165 .00 38.11 O

ATOM 13715 N THR D 100 34.604 39.801 72.007 .00 33.14 N

ATOM 13717 CA THR D 100 34.004 39.285 70.772 .00 32.28 C

ATOM 13719 CB THR D 100 32.617 39.874 70.631 .00 33.08 C

ATOM 13721 OGl THR D 100 31.693 39.072 71.380 .00 32.58 O

ATOM 13723 CG2 THR D 100 32.098 39.948 69.118 .00 37.21 C

ATOM 13727 C THR D 100 34.873 39.702 69.604 .00 31.13 C

ATOM 13728 O THR D 100 35.471 40.785 69.620 .00 30.37 O

ATOM 13729 N TYR D 101 34.993 38.833 68.611 .00 31.37 N

ATOM 13731 CA TYR D 101 35.703 39.160 67.419 .00 30.84 C

ATOM 13733 CB TYR D 101 35.437 38.137 66.314 .00 32.08 C

ATOM 13736 CG TYR D 101 35.629 36.729 66.805 1.00 34.25 C

ATOM 13737 CDl TYR D 101 34.583 35.941 67.097 1.00 38.88 C

ATOM 13739 CEl TYR D 101 34.750 34.707 67.562 .00 39.52 C

ATOM 13741 CZ TYR D 101 35.946 34.269 67.763 .00 38.52 C

ATOM 13742 OH TYR D 101 36.095 33.043 68.238 .00 44.46 O

ATOM 13744 CE2 TYR D 101 36.986 34.992 67.497 .00 36.82 C

ATOM 13746 CD2 TYR D 101 36.835 36.231 67.048 .00 35.53 C

ATOM 13748 C TYR D 101 35.277 40.529 66.932 .00 30.86 C

ATOM 13749 O TYR D 101 34.084 40.893 66.955 .00 33.11 O

ATOM 13750 N TYR D 102 36.280 41.279 66.517 .00 29.81 N

ATOM 13752 CA TYR D 102 36.191 42.562 65.853 .00 29.45 C

ATOM 13754 CB TYR D 102 35.565 42.386 64.481 .00 30.72 C

ATOM 13757 CG TYR D 102 36.154 41.295 63.698 .00 28.52 C

ATOM 13758 CDl TYR D 102 35.328 40.351 63.085 .00 32.83 C

ATOM 13760 CEl TYR D 102 35.834 39.306 62.287 .00 32.70 C

ATOM 13762 CZ TYR D 102 37.178 39.172 62.157 .00 29.94 C

ATOM 13763 OH TYR D 102 37.581 38.164 61.424 .00 30.00 O

ATOM 13765 CE2 TYR D 102 38.019 40.076 62.744 .00 29.21 C

ATOM 13767 CD2 TYR D 102 37.461 41.196 63.511 .00 26.98 C

ATOM 13769 C TYR D 102 35.564 43.702 66.606 .00 29.34 C

ATOM 13770 O TYR D 102 35.211 44.753 65.993 .00 31.06 O

ATOM 13771 N ASP D 103 35.453 43.560 67.911 .00 29.51 N

ATOM 13773 CA ASP D 103 34.621 44.510 68.693 .00 31.57 C

ATOM 13775 CB ASP D 103 33.523 43.743 69.392 .00 32.31 C

ATOM 13778 CG ASP D 103 32.231 44.541 69.603 .00 35.50 C

ATOM 13779 ODl ASP D 103 32.229 45.811 69.699 .00 37.86 O

ATOM 13780 OD2 ASP D 103 31.147 43.932 69.760 .00 33.03 O

ATOM 13781 C ASP D 103 35.493 45.285 69.688 .00 31.31 C

ATOM 13782 O ASP D 103 36.726 45.130 69.654 .00 30.80 O

ATOM 13783 N TYR D 104 34.867 46.062 70.572 .00 32.47 N

ATOM 13785 CA TYR D 104 35.564 47.042 71.419 .00 33.02 C

ATOM 13787 CB TYR D 104 35.387 48.429 70.847 1.00 32.52 C

ATOM 13790 CG TYR D 104 35.855 48.529 69.452 1.00 32.49 C

ATOM 13791 CDl TYR D 104 35.051 48.168 68.386 1.00 34.38 C

ATOM 13793 CEl TYR D 104 35.511 48.235 67.060 1.00 36.47 C

ATOM 13795 CZ TYR D 104 36.784 48.661 66.851 1.00 40.26 C

ATOM 13796 OH TYR D 104 37.335 48.820 65.555 1.00 42.04 O

ATOM 13798 CE2 TYR D 104 37.581 48.984 67.959 1.00 36.79 C

ATOM 13800 CD2 TYR D 104 37.121 48.927 69.194 1.00 32.46 C

ATOM 13802 C TYR D 104 35.042 47.079 72.872 1.00 35.19 C

ATOM 13803 O TYR D 104 35.119 48.144 73.559 1.00 36.99 O

ATOM 13804 N GLU D 105 34.624 45.896 73.331 1.00 35.25 N

ATOM 13806 CA GLU D 105 33.892 45.637 74.609 1.00 37.05 C

ATOM 13808 CB GLU D 105 32.653 44.759 74.311 1.00 38.39 C

ATOM 13811 CG GLU D 105 33.162 43.726 73.210 00 39.20 C

ATOM 13814 CD GLU D 105 32.119 42.797 72.800 00 43.24 C

ATOM 13815 OEl GLU D 105 30.967 43.102 73.166 1.00 50.60 O

ATOM 13816 OE2 GLU D 105 32.424 41.815 72.145 00 41.17 O

ATOM 13817 C GLU D 105 34.955 44.885 75.449 00 34.79 C

ATOM 13818 O GLU D 105 35.096 43.674 75.450 00 33.21 O

ATOM 13819 N PHE D 106 35.794 45.663 76.079 00 34.74 N

ATOM 13821 CA PHE D 106 36.971 45.106 76.719 00 33.56 C

ATOM 13823 CB PHE D 106 37.941 46.202 76.907 00 32.11 C

ATOM 13826 CG PHE D 106 38.218 46.917 75.658 00 32.00 C

ATOM 13827 CDl PHE D 106 38.095 48.287 75.563 1.00 36.38 C ATOM 13829 CEl PHE D 106 38.440 48.935 74.393 00 34 . 66 C

ATOM 13831 CZ PHE D 106 38.862 48.191 73.304 00 30. 31 C

ATOM 13833 CE2 PHE D 106 38.918 46.865 73.389 00 29. 09 C

ATOM 13835 CD2 PHE D 106 38.605 46.234 74.565 00 30. 59 C

ATOM 13837 C PHE D 106 36.657 44.375 78.016 00 34 .43 C

ATOM 13838 O PHE D 106 36.441 44.995 79.034 00 36.37 O

ATOM 13839 N ALA D 107 36.649 43.050 77.934 00 33.57 N

ATOM 13841 CA ALA D 107 36.320 42.181 79.035 00 35.28 C

ATOM 13843 CB ALA D 107 35.614 40.888 78.539 00 35.86 C

ATOM 13847 C ALA D 107 37.554 41.780 79.759 00 35.97 C

ATOM 13848 O ALA D 107 37.409 41.351 80.903 00 38. 66 O

ATOM 13849 N TYR D 108 38.716 41.898 79.101 00 33 .76 N

ATOM 13851 CA TYR D 108 39.993 41.378 79.567 00 34 . 96 C

ATOM 13853 CB TYR D 108 40.460 40.163 78.709 00 34 . 47 C

ATOM 13856 CG TYR D 108 39.440 39.099 78.601 00 35.04 C

ATOM 13857 CDl TYR D 108 38.726 38.850 77.407 00 35.31 C

ATOM 13859 CEl TYR D 108 37.743 37.862 77.365 1.00 35.79 C

ATOM 13861 CZ TYR D 108 37.474 37.182 78.535 1.00 38 . 03 C

ATOM 13862 OH TYR D 108 36.533 36.206 78.654 1.00 44 .30 O

ATOM 13864 CE2 TYR D 108 38.152 37.435 79.680 00 38 . 12 C

ATOM 13866 CD2 TYR D 108 39.139 38.355 79.697 00 37 . 41 C

ATOM 13868 C TYR D 108 41.038 42.466 79.377 00 34 . 37 C

ATOM 13869 O TYR D 108 41.156 42.969 78.276 00 33. 58 O

ATOM 13870 N TRP D 109 41.817 42.778 80.431 00 35. 51 N

ATOM 13872 CA TRP D 109 42.755 43.898 80.499 00 33. 04 C

ATOM 13874 CB TRP D 109 42.188 45.019 81.373 00 33. 12 C

ATOM 13877 CG TRP D 109 40.965 45.716 80.852 00 33. 03 C

ATOM 13878 CDl TRP D 109 39.735 45.182 80.686 00 35.04 C

ATOM 13880 NEl TRP D 109 38.877 46.105 80.136 00 35.58 N

ATOM 13882 CE2 TRP D 109 39.559 47.266 79.932 00 33. 94 C

ATOM 13883 CD2 TRP D 109 40.878 47.049 80.343 00 33.28 C

ATOM 13884 CE3 TRP D 109 41.789 48.075 80.166 00 33 . 80 C

ATOM 13886 CZ3 TRP D 109 41.349 49.277 79.611 00 33. 42 C

ATOM 13888 CH2 TRP D 109 40.051 49.447 79.228 00 33. 69 C

ATOM 13890 CZ2 TRP D 109 39.129 48.465 79.401 00 33.31 C

ATOM 13892 C TRP D 109 43.970 43.405 81.176 00 34 . 87 C

ATOM 13893 O TRP D 109 43.919 42.614 82.081 00 37 . 35 O

ATOM 13894 N GLY D 110 45.108 43.904 80.769 00 35. 09 N

ATOM 13896 CA GLY D 110 46.304 43.773 81.543 00 35.48 C

ATOM 13899 C GLY D 110 46.167 44.509 82.858 00 36. 71 C

ATOM 13900 O GLY D 110 45.170 45.206 83.165 00 35 . 65 O

ATOM 13901 N GLN D 111 47.194 44.292 83.674 00 38 .41 N

ATOM 13903 CA GLN D 111 47.290 44.909 84.986 00 39.88 C

ATOM 13905 CB GLN D 111 48.241 44.104 85.886 00 42.53 C

ATOM 13908 CG GLN D 111 49.725 44.447 85.776 00 42 . 86 C

ATOM 13911 CD GLN D 111 50.463 43.616 84.777 00 41 . 89 C

ATOM 13912 OEl GLN D 111 51.637 43.438 84.917 00 44 .32 O

ATOM 13913 NE2 GLN D 111 49.790 43.179 83.713 00 41.71 N

ATOM 13916 C GLN D 111 47.694 46.381 84.902 00 38 .77 C

ATOM 13917 O GLN D 111 47.649 47.095 85.877 00 40.58 O

ATOM 13918 N GLY D 112 48.078 46.845 83.738 00 36.79 N

ATOM 13920 CA GLY D 112 48.429 48.224 83.606 00 37 .21 C

ATOM 13923 C GLY D 112 49.899 48.474 83.858 00 39.24 C

ATOM 13924 O GLY D 112 50.520 47.788 84.674 00 42. 52 O

ATOM 13925 N THR D 113 50.463 49.436 83.139 00 38. 68 N

ATOM 13927 CA THR D 113 51.785 49.879 83.417 00 41 .03 C

ATOM 13929 CB THR D 113 52.612 49.719 82.180 00 40 . 97 C

ATOM 13931 OGl THR D 113 52.785 48.325 81.891 00 40.85 O

ATOM 13933 CG2 THR D 113 54.036 50.254 82.416 00 42 .53 C

ATOM 13937 C THR D 113 51.750 51.353 83.870 1. 00 42 .14 C

ATOM 13938 O THR D 113 51.250 52.198 83.134 1. 00 40.31 O

ATOM 13939 N LEU D 114 52.270 51.637 85.076 1. 00 44 .50 N

ATOM 13941 CA LEU D 114 52.295 52.984 85.606 00 45. 15 C

ATOM 13943 CB LEU D 114 52.560 52.927 87.087 00 47 .24 C

ATOM 13946 CG LEU D 114 52.578 54.312 87.753 00 48 .79 C

ATOM 13948 CDl LEU D 114 51.232 54.921 87.733 00 49. 87 C

ATOM 13952 CD2 LEU D 114 53.087 54.296 89.213 00 51.70 C

ATOM 13956 C LEU D 114 53.444 53.717 84.956 1 . 00 46. 43 C ATOM 13957 O LEU D 114 54.584 53.494 85.359 1.00 S.45 O

ATOM 13958 N VAL D 115 53.174 54.617 84 008 1.00 44.80 N

ATOM 13960 CA VAL D 115 54.248 55.285 83, 274 1.00 45.32 C

ATOM 13962 CB VAL D 115 53.999 55.303 81.781 1.00 43.97 C

ATOM 13964 CGl VAL D 115 55.038 56.092 81.076 1.00 45.37 C

ATOM 13968 CG2 VAL D 115 54.011 53.915 81.240 00 45.06 C

ATOM 13972 C VAL D 115 54.332 56.717 83, 635 00 46.21 C

ATOM 13973 O VAL D 115 53.342 57.421 83 507 00 46.25 O

ATOM 13974 N THR D 116 55.549 57.149 83.931 00 47.39 N

ATOM 13976 CA THR D 116 55.876 58.442 84.504 00 49.19 C

ATOM 13978 CB THR D 116 56.559 58.139 85, 826 00 51.28 C

ATOM 13980 OGl THR D 116 55.851 57.040 86.446 00 49.66 O

ATOM 13982 CG2 THR D 116 56.561 59.345 86.814 00 52.90 C

ATOM 13986 C THR D 116 56.870 59.154 83, 611 00 50.16 C

ATOM 13987 O THR D 116 57.880 58.600 83.330 1.00 50.46 O

ATOM 13988 N VAL D 117 56.626 60.382 83.209 .00 50.68 N

ATOM 13990 CA VAL D 117 57.511 61.021 82, 292 .00 52.90 C

ATOM 13992 CB VAL D 117 56.786 61.424 81.067 .00 52.02 C

ATOM 13994 CGl VAL D 117 57.669 62.056 80.124 .00 54.34 C

ATOM 13998 CG2 VAL D 117 56.235 60.219 80.389 .00 51.45 C

ATOM 14002 C VAL D 117 58.169 62.215 82, 941 .00 57.15 C

ATOM 14003 O VAL D 117 57.575 63.264 83, 139 .00 59.15 O

ATOM 14004 N SER D 118 59.443 62.064 83.257 .00 59.82 N

ATOM 14006 CA SER D 118 60.162 63.096 83.950 .00 63.47 C

ATOM 14008 CB SER D 118 59.855 62.996 85.452 .00 63.79 C

ATOM 14011 OG SER D 118 60.736 63.764 86.268 .00 66.67 O

ATOM 14013 C SER D 118 61.614 62.834 83.640 .00 66.29 C

ATOM 14014 O SER D 118 62.005 61.685 83, 390 .00 64.91 O

ATOM 14015 N ALA D 119 62.406 63.899 83, 602 .00 54.31 N

ATOM 14017 CA ALA D 119 63.822 63.741 83.347 .00 55.75 C

ATOM 14019 CB ALA D 119 64.349 64.894 82.555 .00 57.76 C

ATOM 14023 C ALA D 119 64.549 63.610 84.672 .00 55.45 C

ATOM 14024 O ALA D 119 65.775 63.529 84.729 .00 56.97 O

ATOM 14025 N ALA D 120 63.807 63.582 85.753 .00 53.85 N

ATOM 14027 CA ALA D 120 64.453 63.464 87.038 .00 53.86 C

ATOM 14029 CB ALA D 120 63.469 63.824 155 .00 53.59 C

ATOM 14033 C ALA D 120 64.930 62.055 87.236 .00 53.49 C

ATOM 14034 O ALA D 120 64.510 61.091 86.561 .00 52.47 O

ATOM 14035 N SER D 121 65.770 61.966 241 .00 54.49 N

ATOM 14037 CA SER D 121 66.445 60.753 607 .00 55.63 C

ATOM 14039 CB SER D 121 67.839 61.096 89 074 .00 58.28 C

ATOM 14042 OG SER D 121 67.715 61.672 90 340 .00 57.66 O

ATOM 14044 C SER D 121 65.723 60.084 89 756 1.00 54.50 C

ATOM 14045 O SER D 121 65.234 60.737 90 667 1.00 54.17 O

ATOM 14046 N THR D 122 65.671 58.761 89 676 .00 54.53 N

ATOM 14048 CA THR D 122 65.177 57.902 90 720 .00 53.23 C

ATOM 14050 CB THR D 122 65.387 56.504 90 241 .00 54.78 C

ATOM 14052 OGl THR D 122 64.463 56.273 89 190 .00 52.62 O

ATOM 14054 CG2 THR D 122 65.040 55.501 91 265 .00 55.87 C

ATOM 14058 C THR D 122 65.900 58.103 92 036 1.00 54.14 C

ATOM 14059 O THR D 122 67.082 58.370 92 070 1.00 57.74 O

ATOM 14060 N LYS D 123 65.155 57.970 93 101 1.00 52.70 N

ATOM 14062 CA LYS D 123 65.617 58.079 94 434 1.00 54.77 C

ATOM 14064 CB LYS D 123 65.602 59.545 94 866 1.00 55.21 C

ATOM 14067 CG LYS D 123 65.630 59.764 96 421 1.00 58.84 C

ATOM 14070 CD LYS D 123 66.294 61.098 96 875 1.00 62.89 C

ATOM 14073 CE LYS D 123 66.371 61.121 98 457 1.00 68.82 C

ATOM 14076 NZ LYS D 123 67.102 62.300 99 097 1.00 74.24 N

ATOM 14080 C LYS D 123 64.761 57.241 95 373 1.00 54.21 C

ATOM 14081 O LYS D 123 63.536 57.235 95 342 1.00 52.84 O

ATOM 14082 N GLY D 124 65.417 56.518 96 234 1.00 57.38 N

ATOM 14084 CA GLY D 124 64.733 55.809 97 291 .00 58.45 C

ATOM 14087 C GLY D 124 64.316 56.758 98 400 .00 58.43 C

ATOM 14088 O GLY D 124 64.894 57.864 98 560 .00 58.61 O

ATOM 14089 N PRO D 125 63.310 56.315 99 155 00 58.47 N

ATOM 14090 CA PRO D 125 62.713 57.103 100 230 1.00 58.38 C

ATOM 14092 CB PRO D 125 61.436 56.350 100 539 1.00 57.92 C

ATOM 14095 CG PRO D 125 61.782 54.878 100 208 1.00 59.26 C ATOM 14098 CD PRO D 125 62.690 54.979 99, 035 1.00 59.00 C

ATOM 14101 C PRO D 125 63.552 57.038 101.469 1.00 62.83 C

ATOM 14102 O PRO D 125 64.321 56.073 101.644 1.00 64.70 O

ATOM 14103 N SER D 126 63.389 58.069 102.297 1.00 63.66 N

ATOM 14105 CA SER D 126 63.821 58.051 103, 670 1.00 68.27 C

ATOM 14107 CB SER D 126 64.670 59.277 104, 016 1.00 71.00 C

ATOM 14110 OG SER D 126 63.979 60.445 103, 680 1.00 70.40 O

ATOM 14112 C SER D 126 62.520 57.927 104, 480 1.00 67.10 C

ATOM 14113 O SER D 126 61.438 58.220 103, 960 1.00 63.05 O

ATOM 14114 N VAL D 127 62.644 57.394 105, 709 1.00 70.81 N

ATOM 14116 CA VAL D 127 61.531 56.782 106.473 1.00 70.08 C

ATOM 14118 CB VAL D 127 61.577 55.231 106.423 1.00 71.07 C

ATOM 14120 CGl VAL D 127 60.469 54.669 107.223 1.00 72.19 C

ATOM 14124 CG2 VAL D 127 61.482 54.719 105.003 1.00 66.98 C

ATOM 14128 C VAL D 127 61.614 57.164 107.935 1.00 73.31 C

ATOM 14129 O VAL D 127 62.406 56.660 108.598 1.00 76.86 O

ATOM 14130 N PHE D 128 60.795 58.080 108.402 1.00 72.76 N

ATOM 14132 CA PHE D 128 60.755 58.481 109.789 1.00 77.52 C

ATOM 14134 CB PHE D 128 60.660 60.012 109.858 1.00 77.44 C

ATOM 14137 CG PHE D 128 61.762 60.709 109.068 1.00 78.35 C

ATOM 14138 CDl PHE D 128 61.473 61.588 108.023 1.00 74.99 C

ATOM 14140 CEl PHE D 128 62.471 62.155 107.297 1.00 73.17 C

ATOM 14142 CZ PHE D 128 63.765 61.868 107.582 1.00 77.82 C

ATOM 14144 CE2 PHE D 128 64.074 61.016 108.582 1.00 80.68 C

ATOM 14146 CD2 PHE D 128 63.089 60.430 109.318 1.00 80.90 C

ATOM 14148 C PHE D 128 59.576 57.790 110.461 1.00 78.03 C

ATOM 14149 O PHE D 128 58.667 57.365 109.780 1.00 74.02 O

ATOM 14150 N PRO D 129 59.604 57.611 111.781 1.00 84.09 N

ATOM 14151 CA PRO D 129 58.457 57.042 112.494 1.00 85.22 C

ATOM 14153 CB PRO D 129 59.078 56.527 113.776 1.00 91.56 C

ATOM 14156 CG PRO D 129 60.132 57.546 114.071 1.00 94.86 C

ATOM 14159 CD PRO D 129 60.703 57.940 112.717 1.00 90.22 C

ATOM 14162 C PRO D 129 57.522 58.179 112.818 1.00 85.06 C

ATOM 14163 O PRO D 129 57.900 59.302 112.572 1.00 85.76 O

ATOM 14164 N LEU D 130 56.343 57.890 113.342 1.00 85.59 N

ATOM 14166 CA LED D 130 55.394 58.881 113.824 1.00 85.82 C

ATOM 14168 CB LEU D 130 54.239 59.068 112.847 1.00 80.81 C

ATOM 14171 CG LEU D 130 54.384 59.615 111.434 1.00 76.34 C

ATOM 14173 CDl LEU D 130 53.028 59.517 110.732 1.00 73.31 C

ATOM 14177 CD2 LEU D 130 54.855 61.068 111.414 1.00 77.79 C

ATOM 14181 C LEU D 130 54.860 58.224 115.070 1.00 90.47 C

ATOM 14182 O LEU D 130 53.815 57.574 115.037 1.00 89.75 O

ATOM 14183 N ALA D 131 55.601 58.344 116.162 1.00 96.32 N

ATOM 14185 CA ALA D 131 55.347 57.554 117.353 1.00101.04 C

ATOM 14187 CB ALA D 131 56.545 57.608 118.237 1.00107.25 C

ATOM 14191 C ALA D 131 54.118 58.036 118.109 1.00102.96 C

ATOM 14192 O ALA D 131 53.813 59.224 118.068 1.00101.97 O

ATOM 14193 N PRO D 132 53.447 57.125 118.830 1.00106.22 N

ATOM 14194 CA PRO D 132 52.215 57.439 119.582 1.00108.61 C

ATOM 14196 CB PRO D 132 51.637 56.027 119.870 1.00109.88 C

ATOM 14199 CG PRO D 132 52.854 55.128 120.013 1.00111.73 C

ATOM 14202 CD PRO D 132 53.831 55.703 119.007 1.00108.34 C

ATOM 14205 C PRO D 132 52.484 58.180 120.916 1.00115.60 C

ATOM 14206 O PRO D 132 51.947 57.773 121.972 1.00120.74 O

ATOM 14207 N SER D 133 53.261 59.267 120.859 1.00116.62 N

ATOM 14209 CA SER D 133 54.103 59.666 122.000 1.00124.00 C

ATOM 14211 CB SER D 133 55.207 60.712 121.636 1.00124.54 C

ATOM 14214 OG SER D 133 54.848 61.677 120.645 1.00118.70 O

ATOM 14216 C SER D 133 53.234 60.103 123.172 1.00129.46 C

ATOM 14217 O SER D 133 52.147 60.677 122.931 1.00127.35 O

ATOM 14218 N SER D 134 53.726 59.793 124.396 1.00136.79 N

ATOM 14220 CA SER D 134 52.982 59.796 125.685 1.00143.02 C

ATOM 14222 CB SER D 134 53.599 60.774 126.704 1.00150.95 C

ATOM 14225 OG SER D 134 53.463 62.111 126.259 1.00149.72 O

ATOM 14227 C SER D 134 51.470 60.022 125.546 1.00140.00 C

ATOM 14228 O SER D 134 50.863 60.833 126.267 1.00144.16 O

ATOM 14229 N LYS D 135 50.881 59.254 124.626 1.00133.42 N

ATOM 14231 CA LYS D 135 49.472 59.353 124.290 1.00130.16 C ATOM 14233 CB LYS D 135 49.180 58.611 122.963 1.00122.30 C

ATOM 14240 C LYS D 135 48.725 58.746 125.472 1.00135.96 C

ATOM 14241 O LYS D 135 48.452 57.551 125.475 1.00135.99 O

ATOM 14242 N SER D 136 48.443 59.541 126.506 1.00141.90 N

ATOM 14244 CA SER D 136 47.762 58.997 127.683 1.00148.08 C

ATOM 14246 CB SER D 136 48.003 59.872 128.938 1.00156.17 C

ATOM 14249 OG SER D 136 47.204 59.449 130.043 1.00160.68 O

ATOM 14251 C SER D 136 46.252 58.781 127.358 1.00145.76 C

ATOM 14252 O SER D 136 45.478 59.749 127.277 1.00145.97 O

ATOM 14253 N THR D 137 45.887 57.508 127.105 1.00143.97 N

ATOM 14255 CA THR D 137 44.495 57.012 126.990 1.00142.86 C

ATOM 14257 CB THR D 137 43.968 56.999 125.484 1.00134.89 C

ATOM 14259 OGl THR D 137 44.846 57.734 124.605 1.00129.83 O

ATOM 14261 CG2 THR D 137 42.567 57.671 125.358 1.00134.26 C

ATOM 14265 C THR D 137 44.440 55.570 127.549 1.00146.23 C

ATOM 14266 O THR D 137 44.505 54.608 126.769 1.00142.87 O

ATOM 14267 N SER D 138 44.364 55.417 128.874 1.00153.23 N

ATOM 14269 CA SER D 138 44.243 54.088 129.508 1.00157.67 C

ATOM 14271 CB SER D 138 43.834 54.215 131.017 1.00166.65 C

ATOM 14274 OG SER D 138 42.567 53.646 131.354 1.00167.36 O

ATOM 14276 C SER D 138 43.278 53.162 128.739 1.00154.58 C

ATOM 14277 O SER D 138 43.711 52.177 128.126 1.00151.95 O

ATOM 14278 N GLY D 139 41.984 53.513 128.758 1.00155.39 N

ATOM 14280 CA GLY D 139 40.916 52.737 128.132 1.00153.62 C

ATOM 14283 C GLY D 139 40.310 53.374 126.872 1.00147.16 C

ATOM 14284 O GLY D 139 39.078 53.540 126.851 1.00148.77 O

ATOM 14285 N GLY D 140 41.159 53.757 125.887 1.00140.58 N

ATOM 14287 CA GLY D 140 40.785 54.070 124.501 1.00133.65 C

ATOM 14290 C GLY D 140 41.900 53.685 123.488 1.00128.29 C

ATOM 14291 O GLY D 140 43.034 53.341 123.877 1.00129.62 O

ATOM 14292 N THR D 141 41.622 53.770 122.181 1.00122.35 N

ATOM 14294 CA THR D 141 42.543 53.206 121.174 1.00117.27 C

ATOM 14296 CB THR D 141 41.749 52.518 120.026 1.00114.37 C

ATOM 14298 OGl THR D 141 41.283 51.237 120.468 1.00118.95 O

ATOM 14300 CG2 THR D 141 42.640 52.107 118.885 1.00110.43 C

ATOM 14304 C THR D 141 43.460 54.289 120.658 1.00112.42 C

ATOM 14305 O THR D 141 43.007 55.385 120.437 1.00110.84 O

ATOM 14306 N ALA D 142 44.744 53.980 120.495 1.00110.72 N

ATOM 14308 CA ALA D 142 45.741 54.969 120.088 1.00107.63 C

ATOM 14310 CB ALA D 142 46.854 55.047 121.088 1.00111.82 C

ATOM 14314 C ALA D 142 46.308 54.630 118.726 1.00102.27 C

ATOM 14315 O ALA D 142 46.122 53.503 118.238 1.00101.65 O

ATOM 14316 N ALA D 143 47.020 55.610 118.149 1.00 98.80 N

ATOM 14318 CA ALA D 143 47.476 55.602 116.748 1.00 93.39 C

ATOM 14320 CB ALA D 143 46.600 56.585 115.878 1.00 89.96 C

ATOM 14324 C ALA D 143 48.970 55.943 116.551 1.00 92.18 C

ATOM 14325 O ALA D 143 49.568 56.769 117.278 1.00 93.80 O

ATOM 14326 N LEU D 144 49.547 55.316 115.529 00 .87 N

ATOM 14328 CA LEU D 144 50.950 55.507 115.213 00 .48 C

ATOM 14330 CB LEU D 144 51.793 54.604 116.101 1.00 93.10 C

ATOM 14333 CG LEU D 144 51.319 53.166 116.222 1.00 94.60 C

ATOM 14335 CDl LEU D 144 51.776 52.328 115.026 1.00 91.71 C

ATOM 14339 CD2 LEU D 144 51.849 52.610 117.557 1.00101.82 C

ATOM 14343 C LEU D 144 51.243 55.237 113.737 1.00 84.16 C

ATOM 14344 O LEU D 144 50.331 54.826 112.998 1.00 81.75 O

ATOM 14345 N GLY D 145 52.504 55.438 113.316 1.00 83.52 N

ATOM 14347 CA GLY D 145 52.856 55.270 111.913 1.00 79.91 C

ATOM 14350 C GLY D 145 54.282 55.538 111.367 1.00 79.57 C

ATOM 14351 O GLY D 145 55.304 55.437 112.066 1.00 83.32 O

ATOM 14352 N CYS D 146 54.312 55.893 110.075 1.00 75.22 N

ATOM 14354 CA CYS D 146 55.508 55.855 109.206 1.00 73.84 C

ATOM 14356 CB CYS D 146 55.664 54.503 108.451 1.00 73.43 C

ATOM 14359 SG CYS D 146 56.308 53.216 109.520 1.00 81.52 S

ATOM 14360 C CYS D 146 55.384 56.912 108.144 1.00 69.05 C

ATOM 14361 O CYS D 146 54.402 56.950 107.391 1.00 65.38 O

ATOM 14362 N LEU D 147 56.406 57.747 108.065 1.00 68.91 N

ATOM 14364 CA LEU D 147 56.432 58.804 107.109 1.00 65.13 C

ATOM 14366 CB LEU D 147 56.963 60.025 107.764 1.00 67.65 C ATOM 14369 CG LEU D 147 57.069 61.227 106.873 1.00 67.06 C

ATOM 14371 CDl LEU D 147 55.724 61.483 106.297 1.00 65.61 C

ATOM 14375 CD2 LEU D 147 57.559 62.440 107.688 00 71.20 C

ATOM 14379 C LEU D 147 57.370 58.331 106.083 00 63.16 C

ATOM 14380 O LEU D 147 58.552 58.304 106.328 00 64.33 O

ATOM 14381 N VAL D 148 56.830 57.899 104.943 00 60.56 N

ATOM 14383 CA VAL D 148 57.671 57.588 103.762 00 59.44 C

ATOM 14385 CB VAL D 148 57.170 56.371 103.022 00 57.55 C

ATOM 14387 CGl VAL D 148 58.149 56.036 101.950 00 56.88 C

ATOM 14391 CG2 VAL D 148 57.071 55.207 103.985 00 60.14 C

ATOM 14395 C VAL D 148 57.880 58.789 102.783 00 57.27 C

ATOM 14396 O VAL D 148 56.988 59.143 102.012 00 56.19 O

ATOM 14397 N LYS D 149 59.063 59.372 102.818 00 57.66 N

ATOM 14399 CA LYS D 149 59.293 60.687 102.272 00 56.80 C

ATOM 14401 CB LYS D 149 59.604 61.579 103.479 00 60.19 C

ATOM 14404 CG LYS D 149 60.038 63.016 103.218 1.00 62.14 C

ATOM 14407 CD LYS D 149 59.519 63.986 104.319 1.00 64.95 C

ATOM 14410 CE LYS D 149 59.517 65.451 103.856 1.00 66.61 C

ATOM 14413 NZ LYS D 149 60.933 65.996 103.508 1.00 69.35 N

ATOM 14417 C LYS D 149 60.435 60.715 101.246 1.00 56.13 C

ATOM 14418 O LYS D 149 61.365 59.926 101.268 1.00 58.22 O

ATOM 14419 N ASP D 150 60.363 61.652 100.340 00 54.55 N

ATOM 14421 CA ASP D 150 61.444 61.929 99.384 00 54.34 C

ATOM 14423 CB ASP D 150 62.629 62.585 100.090 1.00 58.17 C

ATOM 14426 CG ASP D 150 62.264 63.912 100.695 .00 60.09 C

ATOM 14427 ODl ASP D 150 62.982 64.376 101.590 .00 69.14 O

ATOM 14428 OD2 ASP D 150 61.267 64.570 100.383 .00 58.91 O

ATOM 14429 C ASP D 150 61.896 60.772 98.527 .00 52.77 C

ATOM 14430 O ASP D 150 63.026 60.348 98.599 .00 54.66 O

ATOM 14431 N TYR D 151 60.981 60.295 97.682 .00 50.75 N

ATOM 14433 CA TYR D 151 61.252 59.228 96.706 .00 49.16 C

ATOM 14435 CB TYR D 151 60.723 57.880 97.179 .00 49.80 C

ATOM 14438 CG TYR D 151 59.222 57.790 97.252 .00 48.09 C

ATOM 14439 CDl TYR D 151 58.483 57.376 96.154 .00 46.12 C

ATOM 14441 CEl TYR D 151 57.135 57.321 96.171 .00 45.49 C

ATOM 14443 CZ TYR D 151 56.438 57.658 97.307 00 45.19 C

ATOM 14444 OH TYR D 151 55.092 57.521 97.328 00 43.36 O

ATOM 14446 CE2 TYR D 151 57.101 58.077 98.410 00 49.83 C

ATOM 14448 CD2 TYR D 151 58.545 58.130 98.391 00 49.84 C

ATOM 14450 C TYR D 151 60.657 59.567 95.382 00 46.65 C

ATOM 14451 O TYR D 151 59.792 60.426 95.271 00 44.77 O

ATOM 14452 N PHE D 152 61.155 58.867 94.379 1.00 46.98 N

ATOM 14454 CA PHE D 152 60.724 59.046 93.020 00 46.06 C

ATOM 14456 CB PHE D 152 61.221 60.378 92.532 00 46.70 C

ATOM 14459 CG PHE D 152 60.649 60.766 91.240 00 46.30 C

ATOM 14460 CDl PHE D 152 61.258 60.423 90.090 1.00 47.89 C

ATOM 14462 CEl PHE D 152 60.726 60.772 88.909 1.00 47.13 C

ATOM 14464 CZ PHE D 152 59.636 61.473 88.857 1.00 43.58 C

ATOM 14466 CE2 PHE D 152 59.024 61.811 89.990 1.00 45.67 C

ATOM 14468 CD2 PHE D 152 59.510 61.472 91.174 1.00 44.91 C

ATOM 14470 C PHE D 152 61.265 57.933 92.107 1.00 47.13 C

ATOM 14471 O PHE D 152 62.368 57.460 92.281 1.00 46.91 O

ATOM 14472 N PRO D 153 60.458 57.446 91.172 00 47.74 N

ATOM 14473 CA PRO D 153 59.064 57.821 91.009 00 46.84 C

ATOM 14475 CB PRO D 153 58.855 57.629 89.519 00 47.99 C

ATOM 14478 CG PRO D 153 59.782 56.422 89.160 00 49.21 C

ATOM 14481 CD PRO D 153 60.823 56.380 90.221 1.00 49.16 C

ATOM 14484 C PRO D 153 58.259 56.813 91.759 00 46.89 C

ATOM 14485 O PRO D 153 58.853 56.011 92.434 00 46.53 O

ATOM 14486 N GLU D 154 56.945 56.877 91.635 1.00 47.75 N

ATOM 14488 CA GLU D 154 56.045 55.904 92.262 00 49.53 C

ATOM 14490 CB GLU D 154 54.615 56.391 92.071 00 49.61 C

ATOM 14493 CG GLU D 154 54.229 57.558 92.949 00 48.55 C

ATOM 14496 CD GLU D 154 53.234 57.082 94.005 00 51.59 C

ATOM 14497 OEl GLU D 154 53.672 56.795 95.160 00 50.24 O

ATOM 14498 OE2 GLU D 154 52.016 56.961 93.650 00 52.02 O

ATOM 14499 C GLU D 154 56.182 54.533 91.593 00 51.99 C

ATOM 14500 O GLU D 154 56.757 54.438 90.491 1.00 52.94 O ATOM 14501 N PRO D 155 55.706 53.469 92.229 1.00 54.47 N

ATOM 14502 CA PRO D 155 55.067 53.470 93.560 1.00 55.09 C

ATOM 14504 CB PRO D 155 53.979 52.480 93.367 1.00 56.62 C

ATOM 14507 CG PRO D 155 54.662 51.449 92.460 1.00 58.94 C

ATOM 14510 CD PRO D 155 55.738 52.112 91.677 1.00 57.37 C

ATOM 14513 C PRO D 155 55.902 52.909 94.714 1.00 56.44 C

ATOM 14514 O PRO D 155 56.987 52.293 94.496 1.00 57.94 O

ATOM 14515 N VAL D 156 55.356 53.104 95.921 1.00 55.95 N

ATOM 14517 CA VAL D 156 55.900 52.510 97.110 1.00 58.09 C

ATOM 14519 CB VAL D 156 56.074 53.534 98.199 1.00 57.30 C

ATOM 14521 CGl VAL D 156 56.640 52.887 99.512 1.00 60.92 C

ATOM 14525 CG2 VAL D 156 57.072 54.513 97.769 1.00 57.85 C

ATOM 14529 C VAL D 156 54.907 51.505 97.595 1.00 60.29 C

ATOM 14530 O VAL D 156 53.748 51.612 97.316 1.00 61.45 O

ATOM 14531 N THR D 157 55.373 50.518 98.313 1.00 62.28 N

ATOM 14533 CA THR D 157 54.531 49.596 98.993 1.00 64.84 C

ATOM 14535 CB THR D 157 55.070 48.221 98.666 1.00 68.70 C

ATOM 14537 OGl THR D 157 54.767 47.907 97.300 1.00 68.61 O

ATOM 14539 CG2 THR D 157 54.377 47.166 99.467 1.00 74.43 C

ATOM 14543 C THR D 157 54.791 49.880 100.432 1.00 65.43 C

ATOM 14544 O THR D 157 55.929 50.121 100.772 1.00 67.18 O

ATOM 14545 N VAL D 158 53.792 49.826 101.297 1.00 66.13 N

ATOM 14547 CA VAL D 158 54.027 49.793 102.753 1.00 67.84 C

ATOM 14549 CB VAL D 158 53.496 51.066 103.435 1.00 65.69 C

ATOM 14551 CGl VAL D 158 53.812 51.053 104.905 1.00 67.82 C

ATOM 14555 CG2 VAL D 158 54.053 52.331 102.774 1.00 61.61 C

ATOM 14559 C VAL D 158 53.277 48.599 103.351 1.00 72.19 C

ATOM 14560 O VAL D 158 52.314 48.156 102.776 1.00 73.95 O

ATOM 14561 N SER D 159 53.681 48.090 104.507 1.00 75.68 N

ATOM 14563 CA SER D 159 52.984 46.954 105.155 1.00 80.05 C

ATOM 14565 CB SER D 159 53.231 45.659 104.387 1.00 83.26 C

ATOM 14568 OG SER D 159 54.603 45.300 104.525 1.00 84.89 O

ATOM 14570 C SER D 159 53.544 46.773 106.546 1.00 83.51 C

ATOM 14571 O SER D 159 54.718 47.089 106.775 1.00 83.52 O

ATOM 14572 N TRP D 160 52.768 46.211 107.471 1.00 87.04 N

ATOM 14574 CA TRP D 160 53.284 46.101 108.846 1.00 90.70 C

ATOM 14576 CB TRP D 160 52.378 46.873 109.763 1.00 89.83 C

ATOM 14579 CG TRP D 160 52.246 48.303 109.409 1.00 84.69 C

ATOM 14580 CDl TRP D 160 51.543 48.842 108.352 1.00 79.29 C

ATOM 14582 NEl TRP D 160 51.623 50.213 108.391 1.00 73.78 N

ATOM 14584 CE2 TRP D 160 52.373 50.592 109.470 1.00 76.63 C

ATOM 14585 CD2 TRP D 160 52.788 49.408 110.131 1.00 83.36 C

ATOM 14586 CE3 TRP D 160 53.560 49.524 111.289 1.00 87.07 C

ATOM 14588 CZ3 TRP D 160 53.910 50.795 111.732 1.00 86.68 C

ATOM 14590 CH2 TRP D 160 53.494 51.947 111.041 1.00 80.65 C

ATOM 14592 CZ2 TRP D 160 52.723 51.864 109.916 1.00 75.76 C

ATOM 14594 C TRP D 160 53.529 44.669 109.400 1.00 97.32 C

ATOM 14595 O TRP D 160 52.681 43.805 109.261 1.00100.42 O

ATOM 14596 N ASN D 161 54.708 44.447 110.002 1.00100.50 N

ATOM 14598 CA ASN D 161 55.107 43.189 110.664 1.00107.59 C

ATOM 14600 CB ASN D 161 54.168 42.853 111.837 1.00111.38 C

ATOM 14603 CG ASN D 161 54.071 43.990 112.867 1.00109.86 C

ATOM 14604 ODl ASN D 161 53.451 43.837 113.914 1.00113.63 O

ATOM 14605 ND2 ASN D 161 54.700 45.122 112.572 1.00104.12 N

ATOM 14608 C ASN D 161 55.201 42.031 109.686 1.00109.80 C

ATOM 14609 O ASN D 161 54.581 40.995 109.890 1.00113.89 O

ATOM 14610 N SER D 162 56.001 42.232 108.633 1.00107.26 N

ATOM 14612 CA SER D 162 55.962 41.418 107.389 1.00108.05 C

ATOM 14614 CB SER D 162 56.905 40.169 107.464 1.00115.28 C

ATOM 14617 OG SER D 162 56.533 39.196 108.446 1.00122.27 O

ATOM 14619 C SER D 162 54.515 41.104 106.843 1.00106.92 C

ATOM 14620 O SER D 162 54.284 40.170 106.071 1.00109.12 O

ATOM 14621 N GLY D 163 53.558 41.941 107.206 1.00103.43 N

ATOM 14623 CA GLY D 163 52.218 41.849 106.659 1.00102.77 C

ATOM 14626 C GLY D 163 51.214 41.161 107.561 1.00107.96 C

ATOM 14627 O GLY D 163 50.140 40.801 107.100 1.00109.21 O

ATOM 14628 N ALA D 164 51.541 40.998 108.842 1.00111.31 N

ATOM 14630 CA ALA D 164 50.641 40.355 109.775 1.00116.24 C ATOM 14632 CB ALA D 164 51.422 39.829 110.979 1.00121.90 C

ATOM 14636 C ALA D 164 49.498 41.278 110.236 1.00113.12 C

ATOM 14637 O ALA D 164 48.523 40.774 110.836 1.00117.66 O

ATOM 14638 N LEU D 165 49.610 42.594 109.985 1.00106.18 N

ATOM 14640 CA LEU D 165 48.572 43.596 110..366 1.00103.35 C

ATOM 14642 CB LEU D 165 49.213 44.841 111..017 1.00100.01 C

ATOM 14645 CG LEU D 165 49.884 44.675 112..393 1.00104.07 C

ATOM 14647 CDl LEU D 165 49.895 46.010 113..140 1.00100.25 C

ATOM 14651 CD2 LEU D 165 49.215 43.516 113..304 1.00113.44 C

ATOM 14655 C LEU D 165 47.666 44.060 109..206 1.00 99.38 C

ATOM 14656 O LEU D 165 48.126 44.281 108..107 1.00 95.88 O

ATOM 14657 N THR D 166 46.382 44.244 109..481 1.00100.31 N

ATOM 14659 CA THR D 166 45.386 44.436 108..428 1.00 98.64 C

ATOM 14661 CB THR D 166 44.681 43.068 108..100 1.00104.71 C

ATOM 14663 OGl THR D 166 45.324 42.495 106..961 1.00104.16 O

ATOM 14665 CG2 THR D 166 43.167 43.212 107..657 1.00105.79 C

ATOM 14669 C THR D 166 44.388 45.506 108..810 1.00 96.21 C

ATOM 14670 O THR D 166 44.421 46.562 108..235 1.00 91.40 O

ATOM 14671 N SER D 167 43.492 45.242 109..755 1.00100.00 N

ATOM 14673 CA SER D 167 42.552 46.277 110..121 1.00 98.66 C

ATOM 14675 CB SER D 167 41.333 45.736 110..879 1.00103.89 C

ATOM 14678 OG SER D 167 41.735 45.120 112..053 1.00106.75 O

ATOM 14680 C SER D 167 43.307 47.389 110..895 1.00 95.73 C

ATOM 14681 O SER D 167 44.117 47.131 111..821 1.00 96.71 O

ATOM 14682 N GLY D 168 43.027 48.623 110..464 1.00 91.77 N

ATOM 14684 CA GLY D 168 43.655 49.807 110..982 1.00 89.03 C

ATOM 14687 C GLY D 168 44.604 50.335 109..936 1.00 84.96 C

ATOM 14688 O GLY D 168 45.059 51.438 110..086 1.00 83.18 O

ATOM 14689 N VAL D 169 44.892 49.580 108..871 1.00 84.50 N

ATOM 14691 CA VAL D 169 45.986 49.932 107..935 1.00 80.36 C

ATOM 14693 CB VAL D 169 46.696 48.697 107..290 1.00 82.08 C

ATOM 14695 CGl VAL D 169 47.829 49.109 106..355 1.00 76.99 C

ATOM 14699 CG2 VAL D 169 47.248 47.793 108..385 1.00 87.51 C

ATOM 14703 C VAL D 169 45.440 50.853 106..859 1.00 76.27 C

ATOM 14704 O VAL D 169 44.763 50.448 105..886 1.00 75.78 O

ATOM 14705 N HIS D 170 45.770 52.104 107..099 1.00 72.66 N

ATOM 14707 CA HIS D 170 45.447 53.183 106..249 1.00 69.38 C

ATOM 14709 CB HIS D 170 44.786 54.234 107..116 1.00 70.06 C

ATOM 14712 CG HIS D 170 43.316 54.039 107..318 1.00 71.85 C

ATOM 14713 NDl HIS D 170 42.431 53.891 106..277 1.00 70.83 N

ATOM 14715 CEl HIS D 170 41.200 53.816 106..759 1.00 75.91 C

ATOM 14717 NE2 HIS D 170 41.258 53.904 108..075 1.00 76.31 N

ATOM 14719 CD2 HIS D 170 42.571 54.040 108..449 1.00 74.79 C

ATOM 14721 C HIS D 170 46.730 53.740 105..599 1.00 65.87 C

ATOM 14722 O HIS D 170 47.590 54.326 106..240 1.00 64.33 O

ATOM 14723 N THR D 171 46.813 53.616 104..287 1.00 64.92 N

ATOM 14725 CA THR D 171 48.045 53.890 103..569 1.00 61.85 C

ATOM 14727 CB THR D 171 48.525 52.618 102..809 1.00 63.26 C

ATOM 14729 OGl THR D 171 48.681 51.525 103..768 1.00 68.52 O

ATOM 14731 CG2 THR D 171 49.922 52.775 102..220 1.00 60.74 C

ATOM 14735 C THR D 171 48.066 55.083 102..701 1.00 57.66 C

ATOM 14736 O THR D 171 49.097 55.421 102..275 1.00 59.99 O

ATOM 14737 N PHE D 172 47.052 55.841 102..493 1.00 56.24 N

ATOM 14739 CA PHE D 172 47.309 57.278 102..015 1.00 53.44 C

ATOM 14741 CB PHE D 172 47.980 58.182 103..068 1.00 52.85 C

ATOM 14744 CG PHE D 172 47.131 58.461 104.272 1.00 56.06 C

ATOM 14745 CDl PHE D 172 47.421 57.886 105.494 1.00 57.70 C

ATOM 14747 CEl PHE D 172 46.598 58.125 106.593 1.00 61.30 C

ATOM 14749 CZ PHE D 172 45.466 58.949 106.488 1.00 61.98 C

ATOM 14751 CE2 PHE D 172 45.158 59.512 105.286 1.00 61.46 C

ATOM 14753 CD2 PHE D 172 46.002 59.285 104.175 1.00 58.64 C

ATOM 14755 C PHE D 172 48.040 57.484 100.684 1.00 50.18 C

ATOM 14756 O PHE D 172 49.188 57.152 100.499 1.00 48.95 O

ATOM 14757 N PRO D 173 47.323 57.960 99.703 1.00 51.03 N

ATOM 14758 CA PRO D 173 47.966 58.259 98.437 1.00 50.61 C

ATOM 14760 CB PRO D 173 46.828 58.841 97.589 1.00 51.50 C

ATOM 14763 CG PRO D 173 45.802 59.112 98.483 1.00 53.99 C

ATOM 14766 CD PRO D 173 45.876 58.146 99.622 1.00 52.80 C ATOM 14769 C PRO D 173 49.105 59.258 98.568 .00 49.69 C

ATOM 14770 O PRO D 173 49.007 60.262 99.263 .00 50.24 O

ATOM 14771 N ALA D 174 50.192 58.982 97.865 .00 49.12 N

ATOM 14773 CA ALA D 174 51.333 59.885 97.868 .00 48.07 C

ATOM 14775 CB ALA D 174 52.374 59.344 96.969 .00 47.30 C

ATOM 14779 C ALA D 174 50.988 61.267 97.411 .00 48.33 C

ATOM 14780 O ALA D 174 49.996 61.501 96.760 .00 48.62 O

ATOM 14781 N VAL D 175 51.863 62.181 97.732 .00 48.93 N

ATOM 14783 CA VAL D 175 51.693 63.544 97.311 .00 50.08 C

ATOM 14785 CB VAL D 175 51.278 64.396 98.464 .00 52.47 C

ATOM 14787 CGl VAL D 175 51.091 65.789 98.004 .00 56.48 C

ATOM 14791 CG2 VAL D 175 49.992 63.925 99.000 .00 53.12 C

ATOM 14795 C VAL D 175 53.009 64.056 96.790 .00 49.12 C

ATOM 14796 O VAL D 175 54.031 63.730 97.308 .00 48.44 O

ATOM 14797 N LEU D 176 52.965 64.862 95.747 .00 49.70 N

ATOM 14799 CA LEU D 176 54.162 65.349 95.125 .00 49.52 C

ATOM 14801 CB LEU D 176 53.854 65.602 93.685 .00 50.20 C

ATOM 14804 CG LEU D 176 54.982 66.015 92.758 .00 51.28 C

ATOM 14806 CDl LEU D 176 56.160 65.079 92.906 .00 51.18 C

ATOM 14810 CD2 LEU D 176 54.408 65.949 91.360 .00 51.54 C

ATOM 14814 C LEU D 176 54.528 66.631 95.771 .00 51.36 C

ATOM 14815 O LEU D 176 53.750 67.559 95.800 .00 53.28 O

ATOM 14816 N GLN D 177 55.703 66.664 96.348 .00 52.30 N

ATOM 14818 CA GLN D 177 56.173 67.852 97.072 .00 55.83 C

ATOM 14820 CB GLN D 177 57.242 67.468 98.109 .00 56.07 C

ATOM 14823 CG GLN D 177 56.885 66.367 99.070 .00 53.77 C

ATOM 14826 CD GLN D 177 58.093 65.861 99.821 .00 55.31 C

ATOM 14827 OEl GLN D 177 59.134 66.373 99.640 .00 67.15 O

ATOM 14828 NE2 GLN D 177 57.940 64.937 100.701 .00 56.54 N

ATOM 14831 C GLN D 177 56.753 68.909 96.092 .00 57.83 C

ATOM 14832 O GLN D 177 56.895 68.652 94.905 .00 57.07 O

ATOM 14833 N SER D 178 57.105 70.086 96.594 1.00 61.86 N

ATOM 14835 CA SER D 178 57.698 71.128 95.747 1.00 64.24 C

ATOM 14837 CB SER D 178 57.821 72.425 96.515 1.00 68.85 C

ATOM 14840 OG SER D 178 56.592 73.127 96.433 1.00 70.78 O

ATOM 14842 C SER D 178 59.054 70.760 95.178 1.00 63.76 C

ATOM 14843 O SER D 178 59.474 71.301 94.193 1.00 64.54 O

ATOM 14844 N SER D 179 59.735 69.827 95.820 1.00 63.67 N

ATOM 14846 CA SER D 179 61.005 69.276 95.324 00 63.08 C

ATOM 14848 CB SER D 179 61.691 68.545 96.476 00 63.84 C

ATOM 14851 OG SER D 179 60.849 67.484 97.003 00 62.76 O

ATOM 14853 C SER D 179 60.897 68.260 94.149 00 60.11 C

ATOM 14854 O SER D 179 61.972 67.795 93.639 1.00 60.04 O

ATOM 14855 N GLY D 180 59.651 67.856 93.788 1.00 56.93 N

ATOM 14857 CA GLY D 180 59.442 66.838 92.771 1.00 53.61 C

ATOM 14860 C GLY D 180 59.604 65.423 93.306 1.00 51.38 C

ATOM 14861 O GLY D 180 59.592 64.412 92.557 1.00 49.29 O

ATOM 14862 N LEU D 181 59.728 65.348 94.623 1.00 51.34 N

ATOM 14864 CA LEU D 181 59.769 64.068 95.288 1.00 50.39 C

ATOM 14866 CB LEU D 181 60.814 64.149 96.347 1.00 52.46 C

ATOM 14869 CG LEU D 181 62.218 64.303 95.845 1.00 53.18 C

ATOM 14871 CDl LEU D 181 63.179 64.532 97.017 1.00 53.74 C

ATOM 14875 CD2 LEU D 181 62.516 63.006 95.073 1.00 51.26 C

ATOM 14879 C LEU D 181 58.437 63.756 95.964 1.00 49.42 C

ATOM 14880 O LEU D 181 57.823 64.632 96.590 1.00 50.84 O

ATOM 14881 N TYR D 182 57.995 62.517 95.866 1.00 47.37 N

ATOM 14883 CA TYR D 182 56.805 62.099 96.625 1.00 47.21 C

ATOM 14885 CB TYR D 182 56.283 60.780 96.092 1.00 46.17 C

ATOM 14888 CG TYR D 182 55.767 60.930 94.708 1.00 45.87 C

ATOM 14889 CDl TYR D 182 56.557 60.615 93.633 1.00 46.82 C

ATOM 14891 CEl TYR D 182 56.098 60.809 92.348 00 48.35 C

ATOM 14893 CZ TYR D 182 54.813 61.268 92.138 00 47.09 C

ATOM 14894 OH TYR D 182 54.417 61.435 90.868 00 45.62 O

ATOM 14896 CE2 TYR D 182 54.012 61.607 93.185 00 45.99 C

ATOM 14898 CD2 TYR D 182 54.494 61.461 94.465 00 46.47 C

ATOM 14900 C TYR D 182 57.045 61.914 98.120 00 48.05 C

ATOM 14901 O TYR D 182 58.117 61.576 98.545 00 48.45 O

ATOM 14902 N SER D 183 56.034 62.171 98.915 1.00 48.87 N ATOM 14904 CA SER D 183 55.925 61.467 100.149 1.00 51.41 C

ATOM 14906 CB SER D 183 56.474 62.252 101.324 1.00 53.74 C

ATOM 14909 OG SER D 183 55.445 62.952 101.902 1.00 57.05 O

ATOM 14911 C SER D 183 54.518 60.978 100.430 1.00 51.30 C

ATOM 14912 O SER D 183 53.558 61.281 99.726 1.00 50.46 O

ATOM 14913 N LEU D 184 54.452 60.236 101.521 1.00 53.32 N

ATOM 14915 CA LEU D 184 53.409 59.260 101.805 1.00 54.25 C

ATOM 14917 CB LEU D 184 53.948 57.905 101.387 1.00 54.63 C

ATOM 14920 CG LEU D 184 53.018 56.728 101.250 1.00 54.80 C

ATOM 14922 CDl LEU D 184 52.219 56.950 100.076 1.00 53.73 C

ATOM 14926 CD2 LEU D 184 53.879 55.526 101.028 1.00 57.84 C

ATOM 14930 C LEU D 184 53.275 59.190 103.308 1.00 56.22 C

ATOM 14931 O LEU D 184 54.094 59.680 104.021 1.00 57.29 O

ATOM 14932 N SER D 185 52.272 58.516 103.800 1.00 57.35 N

ATOM 14934 CA SER D 185 52.379 58.007 105.174 1.00 59.70 C

ATOM 14936 CB SER D 185 52.049 59.067 106.224 1.00 61.87 C

ATOM 14939 OG SER D 185 50.921 59.813 105.836 1.00 63.92 O

ATOM 14941 C SER D 185 51.474 56.865 105.319 1.00 58.54 C

ATOM 14942 O SER D 185 50.405 56.906 104.803 1.00 55.56 O

ATOM 14943 N SER D 186 51.955 55.837 105.977 1.00 60.18 N

ATOM 14945 CA SER D 186 51.078 54.790 106.428 1.00 63.53 C

ATOM 14947 CB SER D 186 51.565 53.439 105.983 1.00 64.38 C

ATOM 14950 OG SER D 186 51.306 52.536 107.024 1.00 69.79 O

ATOM 14952 C SER D 186 50.824 54.828 107.946 1.00 66.75 C

ATOM 14953 O SER D 186 51.600 55.365 108.716 1.00 68.12 O

ATOM 14954 N VAL D 187 49.700 54.263 108.364 1.00 69.09 N

ATOM 14956 CA VAL D 187 49.165 54.560 109.697 1.00 72.02 C

ATOM 14958 CB VAL D 187 48.374 55.912 109.640 1.00 70.96 C

ATOM 14960 CGl VAL D 187 47.059 55.856 110.271 1.00 72.97 C

ATOM 14964 CG2 VAL D 187 49.184 57.018 110.284 1.00 72.15 C

ATOM 14968 C VAL D 187 48.375 53.380 110.180 1.00 74.57 C

ATOM 14969 O VAL D 187 47.765 52.687 109.388 1.00 73.67 O

ATOM 14970 N VAL D 188 48.480 53.089 111.467 1.00 78.78 N

ATOM 14972 CA VAL D 188 47.669 52.026 112.060 1.00 83.05 C

ATOM 14974 CB VAL D 188 48.424 50.763 112.506 1.00 86.25 C

ATOM 14976 CGl VAL D 188 47.620 49.558 112.107 1.00 88.84 C

ATOM 14980 CG2 VAL D 188 49.766 50.672 111.881 1.00 86.59 C

ATOM 14984 C VAL D 188 46.954 52.550 113.272 1.00 86.01 C

ATOM 14985 O VAL D 188 47.492 53.373 114.027 1.00 87.50 O

ATOM 14986 N THR D 189 45.717 52.090 113.409 1.00 87.42 N

ATOM 14988 CA THR D 189 45.015 52.183 114.633 1.00 90.97 C

ATOM 14990 CB THR D 189 43.536 52.320 114.347 1.00 91.22 C

ATOM 14992 OGl THR D 189 43.307 53.207 113.261 1.00 85.40 O

ATOM 14994 CG2 THR D 189 42.842 52.982 115.480 1.00 95.29 C

ATOM 14998 C THR D 189 45.331 50.835 115.304 1.00 95.78 C

ATOM 14999 O THR D 189 45.260 49.755 114.672 1.00 96.14 O

ATOM 15000 N VAL D 190 45.746 50.884 116.561 1.00 99.65 N

ATOM 15002 CA VAL D 190 45.807 49.661 117.344 1.00105.40 C

ATOM 15004 CB VAL D 190 47.212 48.949 117.308 1.00106.50 C

ATOM 15006 CGl VAL D 190 47.112 47.459 117.879 1.00113.44 C

ATOM 15010 CG2 VAL D 190 47.766 48.880 115.927 1.00101.20 C

ATOM 15014 C VAL D 190 45.413 49.955 118.791 1.00110.32 C

ATOM 15015 O VAL D 190 45.707 51.074 119.275 1.00109.76 O

ATOM 15016 N PRO D 191 44.744 48.985 119.460 1.00114.97 N

ATOM 15017 CA PRO D 191 44.542 49.062 120.915 1.00120.91 C

ATOM 15019 CB PRO D 191 44.043 47.643 121.300 1.00125.96 C

ATOM 15022 CG PRO D 191 44.151 46.807 120.045 1.00123.19 C

ATOM 15025 CD PRO D 191 44.102 47.772 118.900 1.00115.97 C

ATOM 15028 C PRO D 191 45.853 49.394 121.632 1.00122.98 C

ATOM 15029 O PRO D 191 46.839 48.659 121.471 1.00123.92 O

ATOM 15030 N SER D 192 45.865 50.488 122.396 1.00124.39 N

ATOM 15032 CA SER D 192 47.084 50.948 123.089 1.00126.95 C

ATOM 15034 CB SER D 192 46.777 52.111 124.075 1.00129.91 C

ATOM 15037 OG SER D 192 45.532 51.972 124.740 1.00133.29 O

ATOM 15039 C SER D 192 47.947 49.817 123.741 1.00132.43 C

ATOM 15040 O SER D 192 49.151 49.762 123.488 1.00131.87 O

ATOM 15041 N SER D 193 47.354 48.897 124.509 1.00137.70 N

ATOM 15043 CA SER D 193 48.126 47.756 125.053 1.00143.45 C ATOM 15045 CB SER D 193 47.327 46.438 125.055 1.00146.12 C

ATOM 15048 OG SER D 193 46.031 46.630 125.549 1.00145.50 O

ATOM 15050 C SER D 193 49.469 47.537 124.314 1.00141.77 C

ATOM 15051 O SER D 193 50.505 48.003 124.802 1.00144.72 O

ATOM 15052 N SER D 194 49.431 46.911 123.120 1.00137.58 N

ATOM 15054 CA SER D 194 50.576 46.172 122.505 1.00137.39 C

ATOM 15056 CB SER D 194 51.823 47.067 122.336 1.00134.79 C

ATOM 15059 OG SER D 194 51.599 48.394 122.757 1.00130.77 O

ATOM 15061 C SER D 194 50.904 44.805 123.248 .00146.68 C

ATOM 15062 O SER D 194 52.066 44.543 123.660 .00150.94 O

ATOM 15063 N LEO D 195 49.851 43.974 123.443 .00150.16 N

ATOM 15065 CA LEU D 195 49.925 42.548 123.927 .00158.06 C

ATOM 15067 CB LEU D 195 48.727 42.204 124.827 .00162.41 C

ATOM 15073 C LEU D 195 49.952 41.592 122.701 .00156.29 C

ATOM 15074 O LEU D 195 49.549 42.026 121.607 1.00149.95 O

ATOM 15075 N GLY D 196 50.425 40.340 122.842 1.00162.68 N

ATOM 15077 CA GLY D 196 50.727 39.497 121.675 1.00161.42 C

ATOM 15080 C GLY D 196 51.318 40.257 120.455 1.00153.51 C

ATOM 15081 O GLY D 196 50.581 40.655 119.512 1.00147.54 O

ATOM 15082 N THR D 197 52.642 40.478 120.464 1.00153.86 N

ATOM 15084 CA THR D 197 53.368 41.350 119.480 1.00146.39 C

ATOM 15086 CB THR D 197 53.254 40.820 117.993 1.00142.49 C

ATOM 15088 OGl THR D 197 54.045 39.617 117.882 1.00149.06 O

ATOM 15090 CG2 THR D 197 53.887 41.806 116.926 1.00133.52 C

ATOM 15094 C THR D 197 53.138 42.899 119.643 1.00140.17 C

ATOM 15095 O THR D 197 52.525 43.607 118.818 1.00132.05 O

ATOM 15096 N GLN D 198 53.709 43.363 120.759 1.00144.11 N

ATOM 15098 CA GLN D 198 53.825 44.764 121.116 1.00140.43 C

ATOM 15100 CB GLN D 198 54.450 44.898 122.532 1.00147.96 C

ATOM 15107 C GLN D 198 54.697 45.496 120.114 1.00134.16 C

ATOM 15108 O GLN D 198 54.789 46.710 120.188 1.00130.78 O

ATOM 15109 N THR D 199 55.332 44.766 119.190 1.00133.07 N

ATOM 15111 CA THR D 199 56.296 45.351 118.244 1.00128.45 C

ATOM 15113 CB THR D 199 57.444 44.346 117.891 1.00132.44 C

ATOM 15115 OGl THR D 199 57.295 43.134 118.631 1.00139.60 O

ATOM 15117 CG2 THR D 199 58.814 44.873 118.344 1.00135.37 C

ATOM 15121 C THR D 199 55.626 45.857 116.943 1.00120.09 C

ATOM 15122 O THR D 199 55.024 45.084 116.183 1.00118.92 O

ATOM 15123 N TYR D 200 55.751 47.155 116.680 1.00115.03 N

ATOM 15125 CA TYR D 200 55.213 47.730 115.454 1.00107.62 C

ATOM 15127 CB TYR D 200 54.281 48.908 115.795 1.00104.46 C

ATOM 15130 CG TYR D 200 53.147 48.489 116.711 1.00106.68 C

ATOM 15131 CDl TYR D 200 52.975 49.070 117.970 1.00109.12 C

ATOM 15133 CEl TYR D 200 51.963 48.664 118.811 1.00111.35 C

ATOM 15135 CZ TYR D 200 51.115 47.661 118.401 1.00111.91 C

ATOM 15136 OH TYR D 200 50.096 47.221 119.207 1.00115.71 O

ATOM 15138 CE2 TYR D 200 51.271 47.068 117.166 1.00109.67 C

ATOM 15140 CD2 TYR D 200 52.277 47.479 116.333 1.00106.06 C

ATOM 15142 C TYR D 200 56.346 48.132 114.499 1.00104.92 C

ATOM 15143 O TYR D 200 57.050 49.105 114.738 1.00104.47 O

ATOM 15144 N ILE D 201 56.521 47.366 113.424 1.00103.81 N

ATOM 15146 CA ILE D 201 57.545 47.671 112.429 1.00102.21 C

ATOM 15148 CB ILE D 201 58.684 46.590 112.496 1.00107.75 C

ATOM 15150 CGl ILE D 201 59.393 46.656 113.856 1.00113.72 C

ATOM 15153 CDl ILE D 201 60.523 45.656 114.048 1.00119.86 C

ATOM 15157 CG2 ILE D 201 59.717 46.792 111.336 1.00105.63 C

ATOM 15161 C ILE D 201 56.997 47.807 110.980 1.00 96.83 C

ATOM 15162 O ILE D 201 56.436 46.849 110.436 1.00 97.98 O

ATOM 15163 N CYS D 202 57.184 48.959 110.330 1.00 92.25 N

ATOM 15165 CA CYS D 202 56.695 49.076 108.944 1.00 87.63 C

ATOM 15167 CB CYS D 202 56.006 50.398 108.708 1.00 83.22 C

ATOM 15170 SG CYS D 202 57.133 51.729 108.422 1.00 81.91 S

ATOM 15171 C CYS D 202 57.728 48.846 107.836 1.00 86.17 C

ATOM 15172 O CYS D 202 58.868 49.308 107.923 1.00 86.56 O

ATOM 15173 N ASN D 203 57.254 48.177 106.780 1.00 84.31 N

ATOM 15175 CA ASN D 203 58.079 47.615 105.732 1.00 84.05 C

ATOM 15177 CB ASN D 203 57.692 46.171 105.447 1.00 87.34 C

ATOM 15180 CG ASN D 203 57.400 45.402 106.715 1.00 93.02 C ATOM 15181 ODl ASN D 203 58.163 45.443 107.705 1.00 94.19 O

ATOM 15182 ND2 ASN D 203 56.273 44.708 106.709 1.00 95.69 N

ATOM 15185 C ASN D 203 57.828 48.450 104.543 1.00 78.21 C

ATOM 15186 O ASN D 203 56.798 48.349 103.918 1.00 77.07 O

ATOM 15187 N VAL D 204 58.774 49.310 104.262 1.00 75.80 N

ATOM 15189 CA VAL D 204 58.728 50.161 103.109 1.00 71.12 C

ATOM 15191 CB VAL D 204 59.273 51.551 103.467 1.00 69.36 C

ATOM 15193 CGl VAL D 204 58.892 52.562 102.404 1.00 64.60 C

ATOM 15197 CG2 VAL D 204 58.753 51.967 104.837 1.00 69.88 C

ATOM 15201 C VAL D 204 59.544 49.533 101.980 1.00 71.71 C

ATOM 15202 O VAL D 204 60.760 49.405 102.076 1.00 73.45 O

ATOM 15203 N ASN D 205 58.867 49.133 100.912 1.00 70.66 N

ATOM 15205 CA ASN D 205 59.554 48.715 99.697 1.00 71.49 C

ATOM 15207 CB ASN D 205 59.047 47.351 99.229 1.00 74.94 C

ATOM 15210 CG ASN D 205 59.923 46.761 98.143 1.00 78.41 C

ATOM 15211 ODl ASN D 205 60.868 46.022 98.437 1.00 84.36 O

ATOM 15212 ND2 ASN D 205 59.661 47.141 96.874 1.00 77.11 N

ATOM 15215 C ASN D 205 59.436 49.745 98.564 1.00 66.99 C

ATOM 15216 O ASN D 205 58.335 50.165 98.188 1.00 65.08 O

ATOM 15217 N HIS D 206 60.575 50.160 98.031 1.00 66.16 N

ATOM 15219 CA HIS D 206 60.573 51.013 96.867 1.00 63.53 C

ATOM 15221 CB HIS D 206 61.317 52.331 97.165 1.00 62.70 C

ATOM 15224 CG HIS D 206 61.168 53.375 96.096 1.00 59.74 C

ATOM 15225 NDl HIS D 206 62.041 53.481 95.038 1.00 60.76 N

ATOM 15227 CEl HIS D 206 61.660 54.482 94.258 1.00 60.76 C

ATOM 15229 NE2 HIS D 206 60.570 55.028 94.772 1.00 56.00 N

ATOM 15231 CD2 HIS D 206 60.261 54.371 95.937 1.00 57.75 C

ATOM 15233 C HIS D 206 61.213 50.257 95.718 1.00 65.17 C

ATOM 15234 O HIS D 206 62.419 50.373 95.513 1.00 66.55 O

ATOM 15235 N LYS D 207 60.399 49.504 94.963 1.00 65.74 N

ATOM 15237 CA LYS D 207 60.878 48.605 93.893 1.00 67.90 C

ATOM 15239 CB LYS D 207 59.738 47.730 93.323 1.00 69.51 C

ATOM 15246 C LYS D 207 61.623 49.304 92.746 1.00 65.87 C

ATOM 15247 O LYS D 207 62.591 48.740 92.218 1.00 69.15 O

ATOM 15248 N PRO D 208 61.243 50.518 92.351 1.00 61.80 N

ATOM 15249 CA PRO D 208 61.943 51.167 91.206 1.00 60.92 C

ATOM 15251 CB PRO D 208 61.030 52.336 90.824 1.00 56.74 C

ATOM 15254 CG PRO D 208 60.162 52.553 91.983 1.00 55.16 C

ATOM 15257 CD PRO D 208 60.202 51.389 92.929 1.00 58.46 C

ATOM 15260 C PRO D 208 63.412 51.630 91.492 1.00 61.31 C

ATOM 15261 O PRO D 208 64.183 51.824 90.547 1.00 61.70 O

ATOM 15262 N SER D 209 63.764 51.760 92.771 1.00 61.75 N

ATOM 15264 CA SER D 209 65.107 52.100 93.230 1.00 63.81 C

ATOM 15266 CB SER D 209 65.067 53.338 94.118 1.00 61.67 C

ATOM 15269 OG SER D 209 64.729 53.003 95.435 1.00 61.97 O

ATOM 15271 C SER D 209 65.706 51.015 94.078 1.00 68.74 C

ATOM 15272 O SER D 209 66.705 51.256 94.740 1.00 71.24 O

ATOM 15273 N ASN D 210 65.085 49.836 94.113 1.00 70.96 N

ATOM 15275 CA ASN D 210 65.640 48.698 94.851 1.00 75.73 C

ATOM 15277 CB ASN D 210 67.009 48.338 94.275 1.00 79.41 C

ATOM 15280 CG ASN D 210 67.493 47.009 94.735 1.00 85.45 C

ATOM 15281 ODl ASN D 210 66.693 46.147 95.042 1.00 86.85 O

ATOM 15282 ND2 ASN D 210 68.826 46.840 94.825 1.00 91.76 N

ATOM 15285 C ASN D 210 65.746 48.906 96.367 1.00 76.54 C

ATOM 15286 O ASN D 210 66.441 48.163 97.027 1.00 81.20 O

ATOM 15287 N THR D 211 65.043 49.891 96.915 1.00 73.00 N

ATOM 15289 CA THR D 211 65.020 50.089 98.360 1.00 75.11 C

ATOM 15291 CB THR D 211 64.668 51.546 98.732 1.00 71.89 C

ATOM 15293 OGl THR D 211 64.896 52.438 97.628 1.00 70.10 O

ATOM 15295 CG2 THR D 211 65.666 52.070 99.782 1.00 76.24 C

ATOM 15299 C THR D 211 64.044 49.148 99.040 1.00 76.40 C

ATOM 15300 O THR D 211 62.956 48.902 98.516 1.00 74.76 O

ATOM 15301 N LYS D 212 64.432 48.605 100.193 1.00 80.57 N

ATOM 15303 CA LYS D 212 63.545 47.720 100.946 1.00 82.72 C

ATOM 15305 CB LYS D 212 63.730 46.229 100.569 1.00 87.28 C

ATOM 15312 C LYS D 212 63.809 47.921 102.405 1.00 85.46 C

ATOM 15313 O LYS D 212 64.258 47.015 103.062 1.00 91.69 O

ATOM 15314 N VAL D 213 63.489 49.105 102.900 1.00 82.31 N ATOM 15316 CA VAL D 213 63.725 49.519 104, 291 1.00 85.17 C

ATOM 15318 CB VAL D 213 63.756 51.057 104, 298 1.00 82.29 C

ATOM 15320 CGl VAL D 213 63.512 51.666 105, 713 1.00 84.73 C

ATOM 15324 CG2 VAL D 213 65.083 51.527 103, 696 1.00 84.19 C

ATOM 15328 C VAL D 213 62.711 49.064 105, 372 1.00 86.25 C

ATOM 15329 O VAL D 213 61.532 49.006 105, 129 1.00 82.68 O

ATOM 15330 N ASP D 214 63.192 48.774 106, 586 1.00 91.59 N

ATOM 15332 CA ASP D 214 62.311 48.532 107, 749 1.00 92.98 C

ATOM 15334 CB ASP D 214 62.506 47.092 108.271 1.00 98.93 C

ATOM 15337 CG ASP D 214 62.194 46.035 107.204 1.00 97.80 C

ATOM 15338 ODl ASP D 214 61.385 46.349 106.310 1.00 92.43 O

ATOM 15339 OD2 ASP D 214 62.686 44.884 107.157 1.00100.35 O

ATOM 15340 C ASP D 214 62.580 49.592 108.846 1.00 94.11 C

ATOM 15341 O ASP D 214 63.738 50.011 109.018 1.00 97.04 O

ATOM 15342 N LYS D 215 61.519 50.079 109.507 1.00 91.96 N

ATOM 15344 CA LYS D 215 61.627 50.915 110.722 1.00 94.21 C

ATOM 15346 CB LYS D 215 61.440 52.411 110.394 1.00 88.82 C

ATOM 15353 C LYS D 215 60.643 50.460 111.849 1.00 96.87 C

ATOM 15354 O LYS D 215 59.545 50.002 111.586 1.00 94.60 O

ATOM 15355 N ARG D 216 61.060 50.595 113.105 1.00102.63 N

ATOM 15357 CA ARG D 216 60.210 50.347 114.279 1.00105.91 C

ATOM 15359 CB ARG D 216 61.002 49.578 115.347 1.00114.01 C

ATOM 15368 C ARG D 216 59.655 51.654 114.900 1.00104.92 C

ATOM 15369 O ARG D 216 60.344 52.686 114.955 1.00104.73 O

ATOM 15370 N VAL D 217 58.416 51.599 115.392 1.00104.77 N

ATOM 15372 CA VAL D 217 57.769 52.766 116.007 1.00104.59 C

ATOM 15374 CB VAL D 217 56.461 53.206 115.224 1.00 98.42 C

ATOM 15376 CGl VAL D 217 55.939 54.582 115.703 1.00 97.76 C

ATOM 15380 CG2 VAL D 217 56.697 53.270 113.726 1.00 92.68 C

ATOM 15384 C VAL D 217 57.468 52.519 117.502 1.00111.16 C

ATOM 15385 O VAL D 217 56.318 52.305 117.890 1.00111.38 O

ATOM 15386 N GLU D 218 58.506 52.549 118.337 1.00117.44 N

ATOM 15388 CA GLU D 218 58.321 52.507 119.788 1.00124.37 C

ATOM 15390 CB GLU D 218 59.670 52.285 120.523 1.00132.09 C

ATOM 15393 CG GLU D 218 60.454 51.010 120.158 1.00134.04 C

ATOM 15396 CD GLU D 218 61.880 51.285 119.658 1.00134.59 C

ATOM 15397 OEl GLU D 218 62.817 51.026 120.429 1.00140.64 O

ATOM 15398 OE2 GLU D 218 62.079 51.756 118.499 1.00128.11 O

ATOM 15399 C GLU D 218 57.741 53.874 120.171 1.00123.49 C

ATOM 15400 O GLU D 218 57.926 54.837 119.434 1.00119.12 O

ATOM 15401 N PRO D 219 57.050 53.982 121.306 1.00128.14 N

ATOM 15402 CA PRO D 219 56.704 55.312 121.852 1.00129.40 C

ATOM 15404 CB PRO D 219 55.714 54.997 122.995 1.00133.43 C

ATOM 15407 CG PRO D 219 55.987 53.558 123.371 1.00137.50 C

ATOM 15410 CD PRO D 219 56.555 52.876 122.145 1.00132.81 C

ATOM 15413 C PRO D 219 57.965 56.083 122.345 1.00134.98 C

ATOM 15414 O PRO D 219 59.093 55.751 121.941 1.00136.16 O

ATOM 15415 N LYS D 220 57.773 57.114 123.171 1.00138.92 N

ATOM 15417 CA LYS D 220 58.896 57.870 123.769 1.00144.98 C

ATOM 15419 CB LYS D 220 59.535 58.834 122.740 1.00140.79 C

ATOM 15426 C LYS D 220 58.390 58.627 125.010 1.00151.08 C

ATOM 15427 O LYS D 220 57.270 59.161 124.935 1.00147.70 O

ATOM 15428 OXT LYS D 220 59.055 58.684 126.069 1.00159.07 O

ATOM 15429 Cl NAG E 321 29.462 -7.124 22.592 1.00106.85 C

ATOM 15432 C2 NAG E 321 28.616 -8.080 23.433 1.00108.34 C

ATOM 15434 N2 NAG E 321 27.778 -7.288 24.383 1.00103.56 N

ATOM 15436 C7 NAG E 321 26.642 -6.621 24.066 1.00100.08 C

ATOM 15437 07 NAG E 321 25.925 -6.934 23.152 1.00101.12 O

ATOM 15438 C8 NAG E 321 26.201 -5.421 24.839 1.00 96.46 C

ATOM 15442 C3 NAG E 321 29.493 -9.202 24.102 1.00112.92 C

ATOM 15444 03 NAG E 321 28.990 -10.588 23.960 1.00118.55 O

ATOM 15446 C4 NAG E 321 31.051 -9.069 23.931 1.00113.06 C

ATOM 15448 04 NAG E 321 31.842 -9.641 24.956 1.00113.90 O

ATOM 15450 C5 NAG E 321 31.401 -7.591 23.904 1.00108.70 C

ATOM 15452 C6 NAG E 321 32.887 -7.238 24.154 1.00106.46 C

ATOM 15455 06 NAG E 321 33.769 -8.115 23.495 1.00106.75 O

ATOM 15457 05 NAG E 321 30.883 -7.285 22.627 1.00108.92 O

ATOM 15458 Cl NAG E 322 29.267 -9.662 26.756 1.00110.31 C ATOM 15461 C2 NAG E 322 28.521 -10.967 26.426 1.00114.38 C

ATOM 15463 N2 NAG E 322 28.052 -10.913 25.020 1.00116.92 N

ATOM 15465 C7 NAG E 322 28.385 -11.780 24.057 1.00119.42 C

ATOM 15466 07 NAG E 322 29.320 -11.475 23.340 1.00121.28 O

ATOM 15467 C8 NAG E 322 27.607 -13.054 23.839 1.00120.01 C

ATOM 15471 C3 NAG E 322 27.408 -11.226 27.470 1.00113.49 C

ATOM 15473 03 NAG E 322 26.898 -12.548 27.431 1.00115.37 O

ATOM 15475 C4 NAG E 322 27.936 -10.952 28.884 1.00112.48 C

ATOM 15477 04 NAG E 322 26.846 -11.144 29.763 00111.54 O

ATOM 15479 C5 NAG E 322 28.645 -9.568 28.956 00109.09 C

ATOM 15481 C6 NAG E 322 29.263 -9.135 30.280 00107.46 C

ATOM 15484 06 NAG E 322 28.277 -8.551 31.092 00105.99 O

ATOM 15486 05 NAG E 322 29.744 -9.611 28.071 00109.51 O

ATOM 15487 Cl MAN E 323 27.558 -13.638 31.168 00118.90 C

ATOM 15490 C2 MAN E 323 26.564 -13.183 32.294 1.00117.77 C

ATOM 15492 02 MAN E 323 26.868 -11.917 32.907 1.00116.43 O

ATOM 15494 C3 MAN E 323 25.081 -13.205 31.860 1.00117.73 C

ATOM 15496 03 MAN E 323 24.400 -11.977 32.023 1.00112.67 O

ATOM 15498 C4 MAN E 323 24.976 -13.765 30.434 1.00119.97 C

ATOM 15500 04 MAN E 323 23.637 -13.872 30.008 1.00121.73 O

ATOM 15502 C5 MAN E 323 25.750 -15.104 30.461 1.00122.58 C

ATOM 15504 C6 MAN E 323 25.209 -16.307 29.627 1.00125.63 C

ATOM 15507 06 MAN E 323 24.816 -16.087 28.285 1.00125.42 O

ATOM 15509 05 MAN E 323 27.124 -14.727 30.312 1.00121.55 O

ATOM 15510 Cl MAN E 324 25.902 -11.845 35.755 1.00115.15 C

ATOM 15513 C2 MAN E 324 27.196 -11.304 35.140 1.00112.82 C

ATOM 15515 02 MAN E 324 26.996 -11.188 33.736 1.00113.36 O

ATOM 15517 C3 MAN E 324 27.691 -9.982 35.758 1.00109.46 C

ATOM 15519 03 MAN E 324 28.466 -9.354 34.763 1.00107.10 O

ATOM 15521 C4 MAN E 324 26.596 -8.988 36.246 1.00108.78 C

ATOM 15523 04 MAN E 324 27.023 -8.082 37.287 00103.92 O

ATOM 15525 C5 MAN E 324 25.275 -9.715 36.643 00112.59 C

ATOM 15527 C6 MAN E 324 24.102 -8.722 36.842 00110.06 C

ATOM 15530 06 MAN E 324 23.750 -8.085 35.622 00108.11 O

ATOM 15532 05 MAN E 324 24.926 -10.812 35.755 00114. .60 O

ATOM 15533 Cl NAG E 881 51.524 67.218 74.770 00 82.89 C

ATOM 15536 C2 NAG E 881 50.338 68.025 74.160 00 83 .13 C

ATOM 15538 N2 NAG E 881 49.032 67.353 73.995 00 82 .71 N

ATOM 15540 C7 NAG E 881 47.991 67.386 74.866 00 82.73 C

ATOM 15541 07 NAG E 881 47.380 66.346 75.237 00 78 . 34 O

ATOM 15542 C8 NAG E 881 47.603 68.758 75.385 00 84.08 C

ATOM 15546 C3 NAG E 881 50.819 68.571 72.803 1.00 83 . 44 C

ATOM 15548 03 NAG E 881 49.657 69.047 72.125 1.00 81 . 68 O

ATOM 15550 C4 NAG E 881 52.075 69.513 72.964 1.00 84 . 89 C

ATOM 15552 04 NAG E 881 52.660 69.876 71.736 1.00 84. 61 O

ATOM 15554 C5 NAG E 881 53.218 68.848 73.783 1.00 83.76 C

ATOM 15556 C6 NAG E 881 54.566 69.652 74.031 1.00 85. 43 C

ATOM 15559 06 NAG E 881 54.704 71.055 74.263 1.00 83 .52 O

ATOM 15561 05 NAG E 881 52.665 68.147 74.940 1 00 86. 69 O

ATOM 15562 Cl NAG E3281 49.375 31.629 48.905 1 00 52 . 84 C

ATOM 15565 C2 NAG E3281 49.482 31.018 50.297 1 00 51.74 C

ATOM 15567 N2 NAG E3281 50.091 31.941 51.249 1 00 51. 34 N

ATOM 15569 C7 NAG E3281 49.384 32.526 52.211 1 00 50. 13 C

ATOM 15570 07 NAG E3281 48.435 32.032 52.749 1 00 53 .22 O

ATOM 15571 C8 NAG E3281 49.756 33.856 52.704 1 00 50 . 66 C

ATOM 15575 C3 NAG E3281 50.226 29.684 50.255 1 00 52 . 62 C

ATOM 15577 03 NAG E3281 50.116 29.054 51.488 1 00 52.27 O

ATOM 15579 C4 NAG E3281 49.732 28.723 49.174 1 00 54 .50 C

ATOM 15581 04 NAG E3281 50.703 27.716 48.931 1 00 54 . 62 O

ATOM 15582 C5 NAG E3281 49.375 29.441 47.856 1 00 54 .70 C

ATOM 15584 C6 NAG E3281 48.447 28.552 47.010 1 00 55.71 C

ATOM 15587 06 NAG E3281 47.278 28.100 47.717 1 00 53.23 O

ATOM 15589 05 NAG E3281 48.735 30.686 48.078 1 00 51. 91 O

ATOM 15590 Cl NAG E3282 50.357 26.487 49.573 1 . 00 54 . 61 C

ATOM 15592 C2 NAG E3282 51.035 25.314 48.888 1 . 00 56. 44 C

ATOM 15594 N2 NAG E3282 50.443 25.157 47.600 1 . 00 56. 42 N

ATOM 15596 C7 NAG E3282 50.897 25.560 46.412 1. 00 57 . 36 C

ATOM 15597 07 NAG E3282 51.890 26.176 46.141 1 . 00 58. 44 O ATOM 15598 C8 NAG E3282 50.036 25.176 45.269 1.00 58.52 C

ATOM 15602 C3 NAG E3282 50.703 24.044 49.639 1.00 56.65 C

ATOM 15604 03 NAG E3282 51.439 22.899 49.223 1.00 60.43 O

ATOM 15606 C4 NAG E3282 51.144 24.227 51.060 1.00 59.24 C

ATOM 15608 04 NAG E3282 50.928 22.982 51.702 1.00 59.30 O

ATOM 15609 C5 NAG E3282 50.469 25.441 51.718 1.00 57.25 C

ATOM 15611 C6 NAG E3282 51.087 25.744 53.078 1.00 55.87 C

ATOM 15614 06 NAG E3282 52.436 26.070 52.833 1.00 56.35 O

ATOM 15616 05 NAG E3282 50.700 26.585 50.922 1.00 56.55 O

ATOM 15617 Cl MAN E3283 52.049 22.569 52.475 1.00 60.80 C

ATOM 15619 C2 MAN E3283 51.547 22.103 53.804 1.00 59.65 C

ATOM 15621 02 MAN E3283 50.445 21.312 53.451 1.00 58.83 O

ATOM 15623 C3 MAN E3283 52.518 21.233 54.574 1.00 61.41 C

ATOM 15625 03 MAN E3283 51.787 20.219 55.195 1.00 63.34 O

ATOM 15626 C4 MAN E3283 53.562 20.456 53.794 1.00 64.14 C

ATOM 15628 04 MAN E3283 54.592 20.336 54.757 1.00 65.32 O

ATOM 15630 C5 MAN E3283 53.906 21.186 52.484 1.00 64.35 C

ATOM 15632 C6 MAN E3283 54.827 20.559 51.427 1.00 66.91 C

ATOM 15635 06 MAN E3283 54.336 19.397 50.755 1.00 68.16 O

ATOM 15636 05 MAN E3283 52.651 21.452 51.873 1.00 66.18 O

ATOM 15637 Cl MAN E3284 55.217 18.249 50.742 1.00 72.30 C

ATOM 15639 C2 MAN E3284 55.266 17.684 52.167 1.00 74.79 C

ATOM 15641 02 MAN E3284 53.926 17.897 52.622 1.00 75.61 O

ATOM 15643 C3 MAN E3284 55.505 16.199 52.355 1.00 77.19 C

ATOM 15645 03 MAN E3284 55.980 15.970 53.712 1.00 78.27 O

ATOM 15646 C4 MAN E3284 54.050 15.999 51.891 1.00 74.76 C

ATOM 15648 04 MAN E3284 53.363 14.913 52.491 1.00 74.26 O

ATOM 15650 C5 MAN E3284 54.093 16.166 50.311 1.00 75.13 C

ATOM 15652 C6 MAN E3284 52.766 16.286 49.596 1.00 71.00 C

ATOM 15655 06 MAN E3284 51.789 16.197 50.591 1.00 67.75 O

ATOM 15656 05 MAN E3284 54.772 17.312 49.795 1.00 71.66 O

ATOM 15657 Cl MAN E3287 56.557 14.726 54.281 1.00 82.57 C

ATOM 15659 C2 MAN E3287 57.357 13.797 53.289 1.00 86.35 C

ATOM 15661 02 MAN E3287 58.723 13.344 53.449 1.00 90.50 O

ATOM 15662 C3 MAN E3287 56.672 12.482 52.944 1.00 89.09 C

ATOM 15664 03 MAN E3287 57.659 11.558 52.507 1.00 90.57 O

ATOM 15666 C4 MAN E3287 55.887 11.911 54.115 1.00 89.40 C

ATOM 15668 04 MAN E3287 55.294 10.689 53.706 1.00 92.89 O

ATOM 15670 C5 MAN E3287 54.863 12.927 54.621 1.00 83.20 C

ATOM 15672 C6 MAN E3287 54.074 12.364 55.791 1.00 82.64 C

ATOM 15675 06 MAN E3287 53.440 11.149 55.398 1.00 86.10 O

ATOM 15677 05 MAN E3287 55.586 14.035 55.127 1.00 82.62 O

ATOM 15678 Cl MAN E3288 59.546 13.176 54.658 1.00 92.52 C

ATOM 15680 C2 MAN E3288 59.349 14.272 55.676 1.00 89.65 C

ATOM 15682 02 MAN E3288 58.271 13.854 56.471 1.00 91.69 O

ATOM 15684 C3 MAN E3288 60.452 14.356 56.660 1.00 90.23 C

ATOM 15686 03 MAN E3288 59.890 15.181 57.619 1.00 85.18 O

ATOM 15688 C4 MAN E3288 60.741 13.016 57.331 1.00 94.39 C

ATOM 15690 04 MAN E3288 62.025 13.205 57.964 1.00 93.03 O

ATOM 15692 C5 MAN E3288 60.590 11.833 56.315 1.00 97.46 C

ATOM 15694 C6 MAN E3288 60.604 10.434 56.978 1.00101.20 C

ATOM 15697 06 MAN E3288 59.305 9.870 57.154 1.00102.55 O

ATOM 15699 05 MAN E3288 59.440 12.000 55.444 1.00 94.57 O

ATOM 15700 Cl MAN E3285 52.312 20.696 57.165 1.00 71.22 C

ATOM 15702 C2 MAN E3285 51.852 19.512 58.022 1.00 72.51 C

ATOM 15704 02 MAN E3285 52.078 19.647 59.410 1.00 75.71 O

ATOM 15705 C3 MAN E3285 50.367 19.348 57.867 1.00 68.59 C

ATOM 15707 03 MAN E3285 50.001 18.467 58.884 1.00 72.03 O

ATOM 15709 C4 MAN E3285 49.651 20.659 58.121 1.00 64.77 C

ATOM 15711 04 MAN E3285 48.263 20.485 57.943 1.00 65.10 O

ATOM 15713 C5 MAN E3285 50.145 21.664 57.134 1.00 62.44 C

ATOM 15715 C6 MAN E3285 49.441 22.972 57.332 1.00 57.64 C

ATOM 15718 06 MAN E3285 49.509 23.586 56.085 1.00 54.72 O

ATOM 15720 05 MAN E3285 51.537 21.875 57.328 1.00 68.41 O

ATOM 15721 Cl MAN E3286 52.667 20.955 59.763 1.00 77.35 C

ATOM 15723 C2 MAN E3286 52.629 21.164 61.302 1.00 76.62 C

ATOM 15725 02 MAN E3286 52.926 19.916 61.946 1.00 81.48 O

ATOM 15727 C3 MAN E3286 53.567 22.287 61.783 1.00 73.66 C ATOM 15729 03 MAN E3286 54.478 21.668 62.617 1.00 73.03 O

ATOM 15731 C4 MAN E3286 54.473 23.006 60.754 1.00 75.14 C

ATOM 15733 04 MAN E3286 54.449 24.416 61.021 1.00 71.56 O

ATOM 15735 C5 MAN E3286 54.173 22.670 59.260 00 76.43 C

ATOM 15737 C6 MAN E3286 55.208 23.365 58.290 00 76.78 C

ATOM 15740 06 MAN E3286 55.328 23.003 56.888 00 76.61 O

ATOM 15742 05 MAN E3286 54.002 21.227 59.234 00 77.45 O

ATOM 15743 Cl MAN E3289 50.258 15.461 49.783 00 75.63 C

ATOM 15745 C2 MAN E3289 50.034 14.267 48.872 00 75.77 C

ATOM 15747 02 MAN E3289 48.660 14.201 48.764 00 72.18 O

ATOM 15749 C3 MAN E3289 50.526 14.452 47.437 00 78.29 C

ATOM 15751 03 MAN E3289 49.933 13.510 46.572 00 79.15 O

ATOM 15753 C4 MAN E3289 50.081 15.789 46.882 00 77.40 C

ATOM 15755 04 MAN E3289 50.521 15.836 45.541 00 77.75 O

ATOM 15757 C5 MAN E3289 50.659 16.920 47.772 00 76.35 C

ATOM 15759 C6 MAN E3289 50.230 18.330 47.313 00 71.38 C

ATOM 15762 06 MAN E3289 51.375 19.128 47.137 00 68.05 O

ATOM 15764 05 MAN E3289 50.198 16.752 49.136 00 76.70 O

ATOM 15765 Cl NAG E3371 38.544 32.137 31.287 00 73.74 C

ATOM 15768 C2 NAG E3371 39.910 31.524 30.912 00 72.50 C

ATOM 15770 N2 NAG E3371 40.864 31.546 32.013 1.00 71.87 N

ATOM 15772 C7 NAG E3371 41.239 30.472 32.757 1.00 70.84 C

ATOM 15773 07 NAG E3371 40.476 29.555 33.102 .00 70.45 O

ATOM 15774 C8 NAG E3371 42.672 30.426 33.238 .00 70.39 C

ATOM 15778 C3 NAG E3371 40.656 32.193 29.783 .00 75.42 C

ATOM 15780 03 NAG E3371 41.791 31.359 29.440 .00 77.30 O

ATOM 15782 C4 NAG E3371 39.730 32.463 28.602 .00 76.98 C

ATOM 15784 04 NAG E3371 40.419 33.182 27.568 .00 80.73 O

ATOM 15785 C5 NAG E3371 38.541 33.295 29.072 1.00 77.51 C

ATOM 15787 C6 NAG E3371 37.559 33.426 27.908 1.00 79.31 C

ATOM 15790 06 NAG E3371 36.679 34.496 28.177 1.00 80.38 O

ATOM 15792 05 NAG E3371 37.813 32.803 30.226 1.00 77.42 O

ATOM 15793 Cl NAG E3372 41.583 32.516 26.923 1.00 81.06 C

ATOM 15795 C2 NAG E3372 42.328 33.443 25.948 1.00 82.94 C

ATOM 15797 N2 NAG E3372 41.740 34.767 25.838 1.00 82.97 N

ATOM 15799 C7 NAG E3372 42.233 35.902 26.335 1.00 82.90 C

ATOM 15800 07 NAG E3372 41.520 36.914 26.248 1 .00 82.64 O

ATOM 15801 C8 NAG E3372 43.607 35.961 26.991 1.00 82.07 C

ATOM 15805 C3 NAG E3372 42.419 32.829 24.547 1.00 85.35 C

ATOM 15807 03 NAG E3372 43.207 33.591 23.635 1.00 87.85 O

ATOM 15809 C4 NAG E3372 43.054 31.472 24.780 1.00 84.91 C

ATOM 15811 04 NAG E3372 43.723 30.920 23.637 1.00 91.00 O

ATOM 15812 C5 NAG E3372 41.959 30.586 25.314 1.00 82.11 C

ATOM 15814 C6 NAG E3372 42.432 29.260 25.924 .00 80.32 C

ATOM 15817 06 NAG E3372 43.839 29.217 26.026 00 82.02 O

ATOM 15819 05 NAG E3372 41.168 31.317 26.251 00 83.28 O

ATOM 15820 Cl MAN E3373 43.193 31.163 22.297 00 90.26 C

ATOM 15822 C2 MAN E3373 43.289 29.790 21.572 00 89.29 C

ATOM 15824 02 MAN E3373 42.106 29.541 20.822 00 88.30 O

ATOM 15826 C3 MAN E3373 44.594 29.551 20.798 1.00 90.57 C

ATOM 15828 03 MAN E3373 44.458 28.528 19.795 1.00 92.13 O

ATOM 15829 C4 MAN E3373 45.145 30.855 20.206 00 93.50 C

ATOM 15831 04 MAN E3373 46.449 30.566 19.675 00 97.00 O

ATOM 15833 C5 MAN E3373 45.156 32.027 21.232 00 91.21 C

ATOM 15835 C6 MAN E3373 45.845 33.348 20.765 00 92.87 C

ATOM 15838 06 MAN E3373 45.180 34.027 19.709 00 91.50 O

ATOM 15840 05 MAN E3373 43.831 32.276 21.657 00 90.06 O

ATOM 15841 Cl MAN E3374 45.299 27.327 19.975 00 91.45 C

ATOM 15843 C2 MAN E3374 44.665 25.926 19.573 00 90.43 C

ATOM 15845 02 MAN E3374 43.307 25.675 19.923 00 85.56 O

ATOM 15847 C3 MAN E3374 44.958 25.484 18.106 00 93.36 C

ATOM 15849 03 MAN E3374 43.909 25.879 17.264 00 92.46 O

ATOM 15851 C4 MAN E3374 46.346 25.944 17.578 00 95.44 C

ATOM 15853 04 MAN E3374 47.038 24.929 16.892 00 96.98 O

ATOM 15855 C5 MAN E3374 47.209 26.363 18.774 00 94.63 C

ATOM 15857 C6 MAN E3374 48.726 26.471 18.535 00 95.51 C

ATOM 15860 06 MAN E3374 49.041 26.392 17.176 1.00 99.02 O

ATOM 15862 05 MAN E3374 46.576 27.526 19.340 1.00 94.07 O ATOM 15863 Cl NAG E3891 45.808 53.754 43.706 1.00 74.28 C

ATOM 15866 C2 NAG E3891 45.380 54.293 42.335 1.00 76.79 C

ATOM 15868 N2 NAG E3891 43.931 54.439 42.244 1.00 77.53 N

ATOM 15870 C7 NAG E3891 43.082 53.652 41.542 1.00 79.46 C

ATOM 15871 07 NAG E3891 42.117 54.113 40.922 1.00 80.77 O

ATOM 15872 C8 NAG E3891 43.269 52.147 41.487 1.00 77.83 C

ATOM 15876 C3 NAG E3891 45.958 53.518 41.171 1.00 79.74 C

ATOM 15878 03 NAG E3891 45.933 54.287 39.941 1.00 85.15 O

ATOM 15880 C4 NAG E3891 47.366 53.013 41.512 1.00 79.56 C

ATOM 15882 04 NAG E3891 47.766 52.108 40.515 1.00 81.56 O

ATOM 15884 C5 NAG E3891 47.547 52.327 42.862 1.00 74.77 C

ATOM 15886 C6 NAG E3891 49.038 51.935 43.162 1.00 76.89 C

ATOM 15889 06 NAG E3891 50.128 52.559 42.436 1.00 78.59 O

ATOM 15891 05 NAG E3891 47.051 53.133 43.897 1.00 71.16 O

ATOM 15892 Cl NAG E3892 49.560 50.560 39.673 1.00 85.54 C

ATOM 15895 C2 NAG E3892 51.079 50.372 39.365 1.00 87.01 C

ATOM 15897 N2 NAG E3892 51.830 49.743 40.498 1.00 86.01 N

ATOM 15899 C7 NAG E3892 53.058 50.168 41.010 1.00 88.55 C

ATOM 15900 07 NAG E3892 54.106 50.400 40.348 1.00 92.23 O

ATOM 15901 C8 NAG E3892 53.194 50.394 42.509 1.00 85.72 C

ATOM 15905 C3 NAG E3892 51.752 51.651 38.791 1.00 89.93 C

ATOM 15907 03 NAG E3892 53.012 51.322 38.204 1.00 93.75 O

ATOM 15909 C4 NAG E3892 50.816 52.383 37.790 1.00 92.19 C

ATOM 15911 04 NAG E3892 51.469 53.394 36.980 1.00 97.04 O

ATOM 15913 C5 NAG E3892 49.621 52.861 38.652 1.00 90.09 C

ATOM 15915 C6 NAG E3892 48.688 53.957 38.073 1.00 91.72 C

ATOM 15918 06 NAG E3892 49.232 54.724 36.977 1.00 93.72 O

ATOM 15920 05 NAG E3892 48.877 51.689 39.028 1.00 .11 O

ATOM 15921 Cl NAG E4201 42.244 56.852 52.671 1.00 63.81 C

ATOM 15924 C2 NAG E4201 43.345 57.207 51.711 1.00 65.17 C

ATOM 15926 N2 NAG E4201 44.591 56.697 52.209 1.00 64.00 N

ATOM 15928 C7 NAG E4201 45.518 56.163 51.423 1.00 64.41 C

ATOM 15929 07 NAG E4201 45.413 56.030 50.212 1.00 65.04 O

ATOM 15930 C8 NAG E4201 46.795 55.727 52.065 1.00 64.60 C

ATOM 15934 C3 NAG E4201 43.381 58.699 51.617 1.00 68.66 C

ATOM 15936 03 NAG E4201 44.262 58.910 50.571 1.00 74.46 O

ATOM 15938 C4 NAG E4201 42.044 59.335 51.220 1.00 71.76 C

ATOM 15940 04 NAG E4201 41.985 60.760 51.475 1.00 76.53 O

ATOM 15941 C5 NAG E4201 40.915 58.632 51.980 1.00 68.94 C

ATOM 15943 C6 NAG E4201 39.614 58.830 51.256 1.00 70.71 C

ATOM 15946 06 NAG E4201 38.706 58.151 52.076 1.00 70.23 O

ATOM 15948 05 NAG E4201 41.037 57.234 52.120 1.00 65.06 O

ATOM 15949 Cl NAG E4202 42.056 61.718 50.372 1.00 81.14 C

ATOM 15951 C2 NAG E4202 41.295 63.019 50.736 1.00 83.23 C

ATOM 15953 N2 NAG E4202 40.158 62.736 51.611 1.00 81.14 N

ATOM 15955 C7 NAG E4202 40.195 62.977 52.938 1.00 81.55 C

ATOM 15956 07 NAG E4202 40.397 62.106 53.790 1.00 75.71 O

ATOM 15957 C8 NAG E4202 39.997 64.413 53.403 1.00 84.96 C

ATOM 15961 C3 NAG E4202 40.871 63.865 49.497 1.00 87.52 C

ATOM 15963 03 NAG E4202 40.860 65.241 49.801 1.00 91.09 O

ATOM 15965 C4 NAG E4202 41.751 63.571 48.257 1.00 88.70 C

ATOM 15967 04 NAG E4202 41.562 64.296 46.993 1.00 92.75 O

ATOM 15968 C5 NAG E4202 41.445 62.067 48.006 1.00 86.08 C

ATOM 15970 C6 NAG E4202 42.113 61.443 46.760 1.00 86.81 C

ATOM 15973 06 NAG E4202 43.309 60.781 47.074 1.00 86.56 O

ATOM 15975 05 NAG E4202 41.555 61.202 49.146 1.00 82.49 O

ATOM 15976 Cl MAN E4203 41.597 65.753 46.758 1.00 96.52 C

ATOM 15978 C2 MAN E4203 42.878 66.374 46.086 1.00 98.52 C

ATOM 15980 02 MAN E4203 43.726 65.559 45.284 1.00 94.95 O

ATOM 15982 C3 MAN E4203 42.475 67.691 45.329 1.00104.12 C

ATOM 15984 03 MAN E4203 42.359 67.581 43.900 1.00106.03 O

ATOM 15986 C4 MAN E4203 41.185 68.311 45.942 1.00105.60 C

ATOM 15988 04 MAN E4203 41.065 69.698 45.630 1.00108.12 O

ATOM 15990 C5 MAN E4203 41.097 68.015 47.482 1.00102.96 C

ATOM 15992 C6 MAN E4203 39.839 68.676 48.110 1.00104.13 C

ATOM 15995 06 MAN E4203 39.443 67.969 49.283 1.00100.82 O

ATOM 15997 05 MAN E4203 41.313 66.623 47.864 1.00 97.25 O

ATOM 15998 Cl NAG E5041 12.333 62.275 39.325 1.00137.11 C ATOM 16001 C2 NAG E5041 12.986 63.604 39.616 1.00138.53 C

ATOM 16003 N2 NAG E5041 13.364 63.660 41.044 1.00136.10 N

ATOM 16005 C7 NAG E5041 14.433 63.080 41.645 1.00128.39 C

ATOM 16006 07 NAG E5041 14.366 62.041 42.320 1.00122.17 O

ATOM 16007 C8 NAG E5041 15.723 63.845 41.521 1.00127.26 C

ATOM 16011 C3 NAG E5041 12.054 64.733 39.116 1.00144.44 C

ATOM 16013 03 NAG E5041 12.354 64.855 37.737 1.00145.80 O

ATOM 16015 C4 NAG E5041 10.515 64.539 39.222 1.00148.10 C

ATOM 16017 04 NAG E5041 9.929 65.156 40.370 1.00149.99 O

ATOM 16019 C5 NAG E5041 10.130 63.058 39.106 1.00144.50 C

ATOM 16021 C6 NAG E5041 8.913 62.764 38.230 1.00147.36 C

ATOM 16024 06 NAG E5041 7.864 63.649 38.544 1.00153.22 O

ATOM 16026 05 NAG E5041 11.210 62.427 38.472 1.00141.22 O

ATOM 16027 Cl NAG E5441 0.234 62.127 19.661 1.00208.01 C

ATOM 16030 C2 NAG E5441 -0.771 60.962 19.723 1.00206.40 C

ATOM 16032 N2 NAG E5441 -1.608 60.874 18.514 1.00211.28 N

ATOM 16034 C7 NAG E5441 -2.489 59.886 18.295 1.00210.66 C

ATOM 16035 07 NAG E5441 -2.188 58.694 18.394 1.00203.38 O

ATOM 16036 C8 NAG E5441 -3.897 60.288 17.910 1.00217.87 C

ATOM 16040 C3 NAG E5441 -1.619 61.139 20.977 1.00207.06 C

ATOM 16042 03 NAG E5441 -0.826 60.941 22.134 1.00198.40 O

ATOM 16044 C4 NAG E5441 -2.284 62.530 20.945 1.00213.89 C

ATOM 16046 04 NAG E5441 -3.220 62.583 19.875 1.00218.05 O

ATOM 16048 C5 NAG E5441 -1.247 63.664 20.825 1.00214.53 C

ATOM 16050 C6 NAG E5441 -1.248 64.554 22.067 1.00214.73 C

ATOM 16053 06 NAG E5441 -2.440 65.317 22.081 1.00221.76 O

ATOM 16055 05 NAG E5441 0.074 63.184 20.624 1.00209.23 O

ATOM 16056 Cl NAG E5791 8.755 20.579 -4.659 1.00160.24 C

ATOM 16059 C2 NAG E5791 10.058 20.624 -5.492 1.00160.36 C

ATOM 16061 N2 NAG E5791 10.855 21.828 -5.207 1.00160.00 N

ATOM 16063 C7 NAG E5791 12.120 21.841 -4.740 1.00156.65 C

ATOM 16064 07 NAG E5791 12.480 22.620 -3.870 1.00154.63 O

ATOM 16065 C8 NAG E5791 13.175 20.917 -5.291 1.00156.27 C

ATOM 16069 C3 NAG E5791 9.820 20.532 -7.008 1.00164.24 C

ATOM 16071 03 NAG E5791 11.069 20.293 -7.622 1.00162.89 O

ATOM 16073 C4 NAG E5791 8.760 19.484 -7.413 1.00166.62 C

ATOM 16075 04 NAG E5791 8.408 19.503 -8.803 1.00169.76 O

ATOM 16077 C5 NAG E5791 7.504 19.627 -6.540 1.00165.87 C

ATOM 16079 C6 NAG E5791 6.460 18.548 -6.894 1.00167.55 C

ATOM 16082 06 NAG E5791 6.356 18.315 -8.298 1.00169.02 O

ATOM 16084 05 NAG E5791 7.861 19.573 -5.156 1.00161.26 O

END

REFERENCES

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2. Otwinowski, Z., and Minor, W. (1997). Processing of X-ray Diffraction Data Collected in Oscillation Mode. In Macromolecular Crystallography, Volume 276, CW. Carter Jr. and R.M. Sweet, eds. (New York: Academic Press), pp. 307-326.

3. CCP4 (1994). The CCP4 Suite: Programs for Protein Crystallography. Acta Cryst. D50, 760-763.

4. Jones, T.A., Zou, J.Y., Cowan, S.W., and Kjeldgaard (1991). Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A 47 (Pt 2), 110-119.

5. Brunger, A.T., Adams, P.D., Clore, G.M., DeLano, W.L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.S., Kuszewski, J., Nilges, M., Pannu, N.S., Read, R.J., Rice, L.M., Simonson, T., and Warren, G.L. (1998). Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr 54 (Pt 5), 905-921.

6. Winn, M.D., Isupov, M.N., and Murshudov, G.N. (2001). Use of TLS parameters to model anisotropic displacements in macromolecular refinement. Acta Crystallogr D Biol Crystallogr 57, 122-133.

7. Garrett, T.P., McKern, N.M., Lou, M., Elleman, T.C., Adams, T.E., Lovrecz, G.O., Zhu, HJ., Walker, F., Frenkel, MJ., Hoyne, P.A., Jorissen, R.N., Nice, E.C., Burgess, A. W., and Ward, CW. (2002). Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. Cell 110, 763-773.

8. Ogiso, H., Ishitani, R., Nureki, O., Fukai, S., Yamanaka, M., Kim, J.H., Saito, K., Sakamoto, A., Inoue, M., Shirouzu, M., and Yokoyama, S. (2002). Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 110, 775-787.

9. Ferguson, K.M., Berger, M.B., Mendrola, J.M., Cho, H.S., Leahy, DJ., and Lemmon, M.A. (2003). EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. MoI Cell 11, 507-517.

10. Jorgensen W.L., (2004). The many roles of computation on drug discovery. Science 303, 1813-1818.

Claims

What is claimed:

1. A crystal of a receptor-antibody complex comprising a receptor-antibody complex of an epidermal growth factor receptor (EGFR) extracellular domain and cetuximab Fab, wherein the crystal has a resolution determined by X-ray crystallography of better than about 5.0 Angstroms.

2. The crystal of Claim 1 , wherein the crystal has a resolution determined by X-ray crystallography of better than about 4.0 Angstroms.

3. The crystal of Claim 2, wherein the crystal has a resolution determined by X-ray crystallography of better than about 3.0 Angstroms.

4. The crystal of Claim 1, wherein the crystal belongs to space group P2i and has unit cell dimensions a = 77.8 A, b = 70.9 A, c = 147.1 A, and β = 102.5°.

5. The crystal of Claim 1 , having atomic coordinates provided in Table 2.

6. A method for preparing a crystal of a complex of an epidermal growth factor receptor (EGFR) extracellular domain and cetuximab Fab comprising preparing a solution containing the extracellular domain of EGFR and cetuximab Fab fragment, and growing the crystal.

7. The method of Claim 6, wherein the pH of the solution is about 6.0 to about 8.0.

8. A method of identifying a mimetic of cetuximab comprising comparing a three- dimensional structure of the mimetic with a three-dimensional structure determined for the complex of Claim 1.

9. The method of Claim 8, wherein the three dimensional structure of the mimetic is compared with at least a subset of the coordinates provided in Table 2.

10. The method of Claim 8, wherein identifying a mimetic is carried out by comparing the three-dimensional structure of the mimetic against the coordinates of at least one EGFR amino acid bound by cetuximab Fab.

11. The method of Claim 9, wherein the EGFR amino acid is selected from the group consisting of GIn 384, GIn 408, Ser 418, Ser 440, Lys 465, Ser 468, and Asn 469.

12. The method of Claim 8, wherein the locations of atoms of the mimetic that contact EGFR correspond to atoms of cetuximab that contact EGFR.

13. The method of Claim 8, wherein identifying a mimetic comprises comparing a three dimensional structure of a mimetic with the atomic coordinates of a region of EGFR selected from the group consisting of about amino acid residue 350 to about amino acid residue 354, about amino acid residue 380 to about amino acid residue 385, about amino acid residue 405 to about amino acid residue 420, about amino acid residue 435 to about amino acid residue 475 and combinations thereof.

14. The method of Claim 8, wherein the mimetic is a small molecule.

15. The method of Claim 8, wherein the mimetic is a peptide.

16. The method of Claim [0014], wherein the peptide is an antibody or a fragment thereof.

17. The method of Claim 8, wherein the method is carried out with use of a computer.

18. The method of Claim 8, further comprising synthesizing the mimetic and assaying its binding or physiological activity.

19. The method of Claim [0017], wherein the mimetic binds to EGFR with similar affinity as cetuximab Fab.

20. The method of Claim [0017] , wherein the mimetic inhibits dimerization of EGFR expressed by a cell.

21. The method of Claim [0017] , wherein the mimetic inhibits tyrosine kinase activity of the receptor.

22. The method of Claim [0017], wherein the mimetic blocks binding of EGF to EGFR.

23. A method for identifying a mimetic of cetuximab, comprising:

(a) introducing in silico substitutions in at least a single CDR region of cetuximab to obtain a pool of variants; and

(b) using a computer and at least a subset of the EGFR coordinates provided in Table 2 to select a variant with improved EGFR binding characteristics.

24. The method of Claim 23, further comprising determining the biological activity of the mimetic.

25. The method of Claim 23, wherein at most a single substitution is made in each CDR.

26. The method of Claim 23, wherein substitutions are made solely in a CDR3 region.

27. A computer-assisted method for identifying a potential antagonist mimetic that binds the extracellular domain of EGFR comprising a processor, a data storage system, an input device, and an output device, comprising:

(a) inputting into the programmed computer through said input device data comprising the three-dimensional coordinates of a subset of the atoms of EGFR as set out in Table 2;

(a) providing a database of chemical and peptide structures stored in said computer data storage system;

(b) selecting from said database, using computer methods, structures having a portion that is structurally similar to said criteria data set; and

(b) outputting to said output device the selected chemical structures having a portion similar to said criteria data set.

28. A machine-readable medium having stored thereon a plurality of executable instructions to perform a method to identify a mimetic of cetuximab using a crystal of a receptor-antibody complex comprising a receptor-antibody complex of an epidermal growth factor receptor (EGFR) extracellular domain and cetuximab Fab, the method comprising: comparing a three-dimensional structure of a mimetic with a three dimensional structure an epidermal growth factor receptor (EGFR) extracellular domain and cetuximab Fab having an X-ray crystallography resolution of better than about 5.0 Angstroms.

29. The machine-readable medium of Claim [0019] , wherein the EGFR coordinates comprise at least a subset of the atomic coordinates of Table 2.

30. The machine-readable medium of Claim [0019], wherein the three-dimensional structure of the mimetic is compared with at least a subset of the atomic coordinates of Table 2.

31. The machine-readable medium of Claim [0019], wherein identifying a mimetic comprises comparing the three-dimensional structure of a mimetic with a three-dimensional structure of at least one EGFR amino acid bound by cetuximab Fab.

32. The machine-readable medium of Claim [0019], wherein identifying a mimetic comprises comparing a three dimensional structure of a mimetic with the atomic coordinates of a region of EGFR selected from the group consisting of about amino acid residue 350 to about amino acid residue 354, about amino acid residue 380 to about amino acid residue 385, about amino acid residue 405 to about amino acid residue 420, about amino acid residue 435 to about amino acid residue 475 and combinations thereof.

33. A machine-readable medium having stored thereon a plurality of executable instructions to perform a method for identifying a mimetic of cetuximab, the method comprising:

(a) introducing in silico substitutions in at least a single CDR region of cetuximab to obtain a pool of variants; and

(b) using a computer and at least a subset of the EGFR coordinates provided in Table 2 to select a variant with improved EGFR binding characteristics.

34. A cetuximab mimetic identified by the method of any one of Claims 8 to 27.

35. A method of inhibiting EGFR comprising administering a mimetic of Claim [0022].

36. A method of inhibiting tumor growth in a mammal comprising administering a therapeutically effective amount of a cetuximab mimetic of Claim [0022].

37. The method of Claim 36, wherein the tumor expresses EGFR.

38. The method of Claim 36, wherein the tumor overexpresses EGFR.

39. The method of Claim 36, wherein the tumor is a primary tumor.

40. The method of Claim 36, wherein the tumor is a metastatic tumor.

41. The method of Claim 36, wherein the tumor is a refractory tumor.

42. The method of Claim 36, wherein the tumor is a vascularized tumor.

43. The method of Claim 36, wherein the tumor is selected from the group consisting of a colorectal tumor, a head and neck tumor, a pancreatic tumor, a lung tumor, a breast tumor, a renal cell carcinoma, and a glioblastoma.

44. The method of Claim 36, wherein the cetuximab mimetic is administered in combination with an anti-neoplastic agent.

45. The method of Claim 44, wherein the antineoplastic agent is a chemotherapeutic agent.

46. The method of Claim 44, wherein the antineoplastic agent is irinotecan (CPT-11).

47. The method of Claim 44, wherein the antineoplastic agent is radiation.

48. The method of Claim 36, wherein the cetuximab mimetic is administered in combination with an EGFR antagonist.

49. The method of Claim 48, wherein the EGFR antagonist is an intracellular EGFR antagonist.

50. The method of Claim 36, wherein the cetuximab mimetic is administered in combination with a VEGFR antagonist.

51. The method of Claim 36, wherein the cetuximab mimetic is administered in combination with an insulin like growth factor receptor (IGFR) antagonist.

52. A method of treating a hyperproliferative disease comprising administering a therapeutically effective amount of a cetuximab mimetic of Claim [0022].

53. The method of Claim 52, wherein the hyperproliferative disease is psoriasis.

54. The method of Claim 52, wherein the cetuximab mimetic is administered in combination with a topical or systemic agent for psoriasis.

55. The method of Claim 52, wherein the cetuximab mimetic is administered in combination with a corticosteroid.

56. The method of Claim 52, wherein the cetuximab mimetic is administered in combination with a retinoid.